CN214073268U

CN214073268U - Cell detection apparatus

Info

Publication number: CN214073268U
Application number: CN202022786989.7U
Authority: CN
Inventors: 周辉
Original assignee: Guangdong Puyu Flying Biotechnology Co ltd
Current assignee: Guangdong Puyu Flying Biotechnology Co ltd
Priority date: 2020-11-25
Filing date: 2020-11-25
Publication date: 2021-08-31
Anticipated expiration: 2030-11-25

Abstract

The utility model relates to a cell detection equipment's technical field provides a cell detection equipment includes: the skin contact device comprises a skin contact device for contacting with the skin of a user, an ultrasonic probe for emitting at least two ultrasonic waves towards the skin contacting with the skin contact device and collecting the ultrasonic waves, a laser device for emitting a laser beam with a predetermined wavelength and focusing on the skin contacting with the skin contact device, and a plurality of ultrasonic wave collecting units arranged on the ultrasonic probe and positioned outside the laser beam. When the laser beam irradiates on the preset cells, the surfaces of the preset cells are heated and expanded to generate ultrasonic waves, the ultrasonic waves are collected by the ultrasonic wave collecting units, and the ultrasonic signals of the preset cells can be obtained by a user through the ultrasonic waves collected by the ultrasonic wave collecting units.

Description

Cell detection apparatus

Technical Field

The utility model belongs to the technical field of cell detection equipment, more specifically say, relate to a cell detection equipment.

Background

Medical research shows that: cancer patients have some cancer cells entering the blood system in early stage, and how to detect circulating tumor cells entering the blood becomes a key problem for early cancer detection. The in-vivo fluorescence labeling flow cytometer developed in recent years overcomes the problem that the imaging detection cannot detect the circulating tumor cells entering blood of a cancer patient at early stage, and provides a new application method for the early detection of the cancer patient. Therefore, how to detect tumor cells in real time in vivo is an urgent problem.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a cell detection equipment to solve the technical problem who detects the cell on the human tissue that exists among the prior art.

In order to achieve the above object, the utility model adopts the following technical scheme: provided is a cell detection device including: the skin contact device comprises a skin contact device used for contacting with the skin of a user, an ultrasonic probe used for emitting at least two ultrasonic waves towards the skin contacted with the skin contact device and collecting the ultrasonic waves, a laser device used for emitting a laser beam with a preset wavelength and focusing on the skin contacted with the skin contact device, and a plurality of ultrasonic wave collecting units arranged on the ultrasonic probe and positioned outside the laser beam.

Further, the working frequency of the ultrasonic probe is 1-50 MHz; the working frequency of the ultrasonic wave collecting unit is 50-100 MHz.

The ultrasonic diagnosis device further comprises a data acquisition system and an image display system, wherein the data acquisition system is used for collecting the ultrasonic waves received by the ultrasonic wave collection units and calculating the number of the preset spectrum cells, and the image display system is used for displaying the data acquired by the data acquisition system to the preset number of the spectrum cells.

Further, the laser device comprises a first laser for emitting a laser beam with a predetermined wavelength, a first optical transmission channel for transmitting the laser beam, a second laser for generating an indicating beam, and a second optical transmission channel for transmitting the indicating beam; the downstream of the second optical transmission path meets and coincides with the downstream of the first optical transmission path.

Further, a dichroic mirror for transmitting the laser beam and reflecting the indication beam is arranged at the intersection of the second optical transmission channel and the first optical transmission channel.

Further, the pulse frequency of the laser beam is 0.01-0.5MHz laser.

Further, a plurality of the ultrasonic wave collecting units are arranged around the first optical transmission channel.

Furthermore, a laser probe is arranged at the tail end of the first optical transmission channel, the ultrasonic wave collecting units are distributed along a circular path, and the laser probe is positioned at the center of the circular path.

The utility model also provides a cell detection method, include:

contacting a skin contact with a user's skin;

the ultrasonic probe emits at least two ultrasonic waves to the skin in contact with the skin contactor and collects the reflected ultrasonic waves;

the laser device emits a laser beam with a preset wavelength and focuses on the skin contacted with the skin contactor; and collecting ultrasonic waves generated from the skin irradiated with the laser beam by an ultrasonic wave collecting unit outside the laser beam.

Further, the data acquisition system collects the ultrasonic waves received by the ultrasonic wave collection units and calculates the number of cells with a preset frequency spectrum;

and the data image display system displays that the data acquisition system acquires the preset number of the spectrum cells.

The utility model provides a cell detection equipment's beneficial effect lies in: compared with the prior art, the cell detection equipment provided by the utility model has the advantages that the skin contactor is contacted with the skin, the ultrasonic probe emits at least two beams of ultrasonic waves to the skin contactor and the skin, and the ultrasonic probe collects the reflected ultrasonic waves to carry out ultrasonic inspection on the skin; the user can obtain the ultrasonic image according to ultrasonic inspection, then passes through laser device transmission laser beam and focuses on the required detection position on skin, and when laser beam shines on predetermined cell, the surface heating inflation of predetermined cell and production ultrasonic wave, the ultrasonic wave is carried out the ultrasonic wave by a plurality of ultrasonic wave collection units and is collected, and the ultrasonic signal of predetermined cell can be known to the user through the ultrasonic wave that a plurality of ultrasonic wave collection units were collected.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for the embodiments or the prior art descriptions will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without inventive labor.

Fig. 1 is a schematic diagram of a cell detection device according to an embodiment of the present invention.

Wherein, in the figures, the respective reference numerals:

1-a signal generator; 2-a first laser; a 3-dichroic mirror; 4-a second laser; 5-a reflector; 61-a first optical transmission channel; 62-a second optical transmission channel; 71-a beam combiner; 72-a first convex lens; 73-a second convex lens; 74-a third convex lens; 751-a first slide rail; 752-second slide rail; 76-concave lens; 81-ultrasonic probe; 82-a laser probe; 83-an ultrasonic wave collection unit; 84-signal transmission line; 85-data acquisition system; 86-a data image display system; 87-skin contact.

Detailed Description

In order to make the technical problem, technical solution and advantageous effects to be solved by the present invention more clearly understood, the following description is given in conjunction with the accompanying drawings and embodiments to illustrate the present invention in further detail. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

It will be understood that when an element is referred to as being "secured to" or "disposed on" another element, it can be directly on the other element or be indirectly on the other element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or be indirectly connected to the other element.

It will be understood that the terms "length," "width," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are used in an orientation or positional relationship indicated in the drawings for convenience in describing the invention and to simplify the description, and are not intended to indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and are therefore not to be considered limiting of the invention.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless specifically limited otherwise.

Referring to FIG. 1, a cell detecting apparatus according to the present invention will now be described. The cell detection apparatus includes: a skin contact 87 for contacting the skin of a user, an ultrasound probe 81 for emitting at least two ultrasound waves towards the skin in contact with the skin contact 87 and collecting the ultrasound waves, a laser device for emitting a laser beam of a predetermined wavelength and focusing on the skin in contact with the skin contact 87, and a plurality of ultrasound collecting units 83 arranged on the ultrasound probe 81 and outside the laser beam.

Thus, skin contact 87 is in contact with the skin, ultrasound probe 81 transmits at least two ultrasound waves to skin contact 87 and the skin, and ultrasound probe 81 collects the reflected ultrasound waves to perform ultrasound examination of the skin (specifically, in one embodiment, the transmitting unit of ultrasound probe 81 that transmits ultrasound waves is also capable of receiving the transmitted ultrasound waves at the same time; specifically, in one embodiment, at least two ultrasound probes 81 form a double point-by-point focusing mode for performing ultrasound examination); the user can obtain an ultrasonic image according to ultrasonic examination, then emits a laser beam through a laser device and focuses the laser beam on a position to be detected on the skin, when the laser beam is focused and irradiated on a predetermined cell, the surface of the predetermined cell is heated and expanded to generate ultrasonic waves, the ultrasonic waves are collected by the plurality of ultrasonic wave collecting units 83, and the user can know (the user can know the intensity or frequency of the ultrasonic waves generated by the predetermined cell) the ultrasonic signals of the predetermined cell through the ultrasonic waves collected by the plurality of ultrasonic wave collecting units 83.

Optionally, in one embodiment, the ultrasound wave emitting structure on the ultrasound probe 81 also receives ultrasound waves at the same time.

Optionally, in one embodiment, the ultrasound probe 81 forms an image in a dual point-by-point focusing manner. Specifically, in one embodiment, the ultrasonic dual point-by-point focusing method may adopt the technical solution (patent name: method and apparatus for ultrasonic imaging; publication number: CN 106037805A).

Optionally, in one embodiment, skin contact 87 is in contact with the user's wrist.

Further, referring to fig. 1, as an embodiment of the cell detection device provided by the present invention, the skin contactor 87 is a wrist band. Therefore, the wrist strap is sleeved on the skin to conveniently position the skin.

Further, referring to fig. 1, as a specific embodiment of the cell detection apparatus provided by the present invention, the wrist strap is provided with a light hole for passing the laser beam. Therefore, the laser beam can reach the skin sleeved on the wrist strap through the light through hole.

Further, referring to fig. 1, as an embodiment of the cell detection device of the present invention, the wrist band is made of poly N, N-dimethyl styrene. Thus, the toughness is good and the corrosion resistance is good.

Further, referring to fig. 1, as an embodiment of the cell detection apparatus provided by the present invention, the laser device includes a first laser 2 for emitting a laser beam with a predetermined wavelength, a first light transmission channel 61 for transmitting the laser beam, a second laser 4 for generating an indication beam, and a second light transmission channel 62 for transmitting the indication beam; downstream of the second light transmission path 62 meets and coincides with downstream of the first light transmission path 61. In this way, the laser beam generated by the first laser 2 is transmitted through the first optical transmission channel 61, and the indication beam generated by the second laser 4 is converged into the first optical transmission channel 61 along the second optical transmission channel 62 to indicate the laser beam.

Further, referring to fig. 1, as a specific embodiment of the cell detection apparatus provided by the present invention, a dichroic mirror 3 for transmitting the laser beam and reflecting the indication beam is disposed at the intersection of the second light transmission channel 62 and the first light transmission channel 61. In this manner, the laser beam is transported along the first light transmission channel 61 and can continue along the first light transmission channel 61 through the dichroic mirror 3; the indicator beam is reflected by the dichroic mirror 3 along the second light transmission channel 62 into the first light transmission channel 61 and is transported along the first light transmission channel 61.

Further, referring to fig. 1, as a specific embodiment of the cell detection apparatus provided by the present invention, the laser beam pulse frequency is 0.01-0.5MHz laser. Therefore, the laser beam can adjust the frequency to adapt to different materials conveniently.

Further, referring to fig. 1, as a specific embodiment of the cell detection apparatus provided by the present invention, a plurality of ultrasonic wave collecting units 83 are disposed around the first light transmission channel 61. In this way, the ultrasonic waves generated by the laser beam emitted from the first optical transmission channel 61 irradiating the skin can be efficiently received by the plurality of ultrasonic wave collecting units 83.

Further, referring to fig. 1, as a specific embodiment of the cell tissue detecting device provided by the present invention, the working frequency of the ultrasonic probe 81 is 1-50 MHz; the operating frequency of the ultrasonic wave collecting unit 83 is 50-100 MHz.

Further, please refer to fig. 1, which is a specific embodiment of the cellular tissue detecting device according to the present invention, further comprising a data collecting system 85 for collecting the ultrasonic waves received by the plurality of ultrasonic wave collecting units 83 and calculating the predetermined number of spectral cells, and a data image display system 86 for displaying that the data collecting system obtains the predetermined number of spectral cells. In this manner, the data acquisition system 85 separates cells (e.g., cancer cells) having a predetermined frequency spectrum from the frequency spectrum collected by the plurality of ultrasound collection units 83, counts the number of cells, and displays the number of cells on the data image display system 86 (e.g., a display) to inform the user.

Specifically, in one embodiment, the ultrasound collecting unit 83 is an ultrasound transducing unit (the ultrasound waves received by the ultrasound collecting unit 83 are locally converted into electrical signals). Specifically, in one embodiment, the ultrasonic wave collecting unit 83 is an element for collecting ultrasonic waves. In particular, in one embodiment, the ultrasound collection unit 83 may also convert the ultrasound into electrical/optical information for analysis.

Further, please refer to fig. 1, as a specific embodiment of the cell detection apparatus provided by the present invention, a laser probe 82 is disposed at the end of the first optical transmission channel 61, a plurality of ultrasonic wave collecting units 83 are disposed along the circular ring shaped path, and the laser probe 82 is located at the center of the circular ring shaped path. In this way, the ultrasonic waves generated by the laser beam irradiated onto the cell surface by the laser probe 82 can be received more uniformly by the plurality of ultrasonic wave collecting units 83 outside the laser probe 82.

Optionally, in one embodiment, the laser wavelength generated by the second laser 4 is 561 nm.

Optionally, in one embodiment, the first laser 2 is focused on a blood vessel (such as a blood vessel of the skin) by the laser probe 82 under the direction of green laser light generated by the 561nm laser.

Specifically, in one embodiment, the first light transmission channel 61 may be any one or more of a spatial path, an optical fiber path, and a lens group.

Specifically, in one embodiment, the second optical transmission channel 62 may be any one or more of a spatial path, an optical fiber path, and a lens group.

Specifically, in one embodiment, the ultrasonic probe 81 is any one of a water immersion type twin crystal longitudinal wave straight probe, a water immersion type single crystal longitudinal wave straight probe, a water immersion type inclined probe, a twin crystal transverse wave inclined probe, a circumferential curvature probe, a radial curvature probe, a water immersion type point focusing probe, a water immersion type line focusing surface wave probe, and a twin crystal flushing probe.

Specifically, in one embodiment, a mirror 5 is disposed on the second light transmission channel 62 to change the orientation of the pointing light beam. Therefore, the operation is convenient and the cost is low.

Specifically, in one embodiment, the first laser 2 is any one of a femtosecond laser, a solid laser, a semiconductor laser, a gas laser, a fiber laser, and a dye laser.

Alternatively, in one embodiment, the ultrasonic wave collection unit 83 is a multi-array element array composite wafer.

In particular, in one embodiment, the composite piezoelectric wafer is a piezoelectric ceramic wafer, so that the sensitivity is high and the cost is low.

Optionally, in an embodiment, a beam shaper is disposed on the optical transmission channel. In this manner, the shape of the laser beam on the optical transmission channel (e.g., the spot size/shape within the optical transmission channel) is easily adjusted.

Specifically, in one embodiment, the beam shaper includes a first convex lens 72, a second convex lens 73, a third convex lens 74, a first slide rail 751, and a second slide rail 752, respectively, on the light transmission channel; the first convex lens 72 is adjusted in position along the optical transmission path by a first slide rail 751, and the third convex lens 74 is adjusted in position along the optical transmission path by a second slide rail 752. Thus, the spot size/shape in the light transmission channel can be changed by adjusting the positions of the first convex lens 72, the second convex lens 73 and the third convex lens 74.

Specifically, in one embodiment, a beam combiner 71 is disposed on the optical transmission path upstream of the first convex lens 72. In this way, the multiple laser beams in the laser source can be converged into the optical transmission channel by the beam combiner 71.

Specifically, in one embodiment, a concave lens 76 downstream of the third convex lens 74; in this way, beam shape/focus adjustment is facilitated.

Specifically, in one embodiment, the laser beam of the first laser 2 is a femtosecond laser.

Specifically, in one embodiment, the ultrasound diagnostic apparatus further includes a data acquisition system 85 for collecting and counting the electrical signals output by the ultrasound probe 81, and the data acquisition system 85 is electrically connected to the ultrasound probe 81. In this way, the ultrasonic signals collected by the ultrasonic probe 81 are transmitted to the data acquisition system 85 for statistics (the statistics can be based on the intensity/frequency of the ultrasonic waves collected by the ultrasonic probe 81).

Specifically, in one embodiment, the data acquisition system 85 is electrically connected to a plurality of ultrasound collection units 83. In this way, the ultrasonic signals collected by the plurality of ultrasonic wave collecting units 83 are transmitted to the data collecting system 85 for statistics (the statistics may be based on the intensity/frequency of the ultrasonic waves collected by the plurality of ultrasonic wave collecting units 83).

Specifically, in one embodiment, the laser beam impinging on the predetermined cells produces a predetermined frequency/predetermined ultrasound intensity that is collected by the data acquisition system 85 and counted.

Specifically, in one embodiment, the system further comprises a data image display system 86, the data image display system 86 is electrically connected to the data acquisition system 85, and the predetermined number of cells acquired by the data acquisition system 85 is displayed by the data image display system 86. Specifically, in one embodiment, the data image display system 86 is a display.

Specifically, in one embodiment, the ultrasound probe 81 transmits signals to the data acquisition system 85 via a first signal transmission line 84. Specifically, in one embodiment, the data acquisition system 85 transmits the signal to the data image display system 86 via the second signal transmission line 84.

Specifically, in one embodiment, the data acquisition system 85 processes the detected ultrasonic signals of the target cells (such as circulating tumor cells, blood cells, lymphocytes and other cells in blood) and quantitatively analyzes the number of cells focused on the blood vessel by the laser in unit time, so as to effectively retain the frequency band signals generated by the tumor cells and filter out noise signals of other bands; the detection results are finally displayed on a data image display system 86.

Specifically, in one embodiment, the laser probe 82 is embedded within the ultrasound probe 81. Thus, the laser probe 82 and the ultrasonic probe 81 are very strong.

Specifically, in one embodiment, the laser probe 82 emits a beam perpendicular to the skin to be detected. Facilitating the exit beam to enter the skin.

Specifically, in one embodiment, signal driver 1 pulses to control the emission of first laser 2 on/off (e.g., signal driver 1 pulses high to turn on first laser 2 emission). Thus, it is very convenient to control the first laser 2 to emit.

Specifically, in one embodiment, the waveform signal emitted by the signal exciter 1 is a linear wave or a square wave.

Specifically, in one embodiment, the laser wavelength of the first laser 2 is 1064nm, the pulse energy is 20-200 muJ, the pulse time is less than 10ns, and the pulse frequency is 0.01-0.5 MHz.

Specifically, in one embodiment, the concentric circular array elements are located in the middle of the ultrasonic probe 81 and the laser probe 82 is located in the middle of the concentric circular array elements.

Specifically, in one embodiment, the ultrasound probe 81 has more than two array elements to transmit ultrasound waves, and a single ultrasound wave is implemented by more than one aperture respectively, and after the ultrasound wave is transmitted, the array elements in the current aperture are used to receive echoes.

Specifically, in one embodiment, a wrist of a person with a skin contactor 87 is placed under an ultrasonic probe 81, the ultrasonic probe 81 transmits ultrasonic waves through more than two array elements on the probe, and receives echoes by using the array elements in the current aperture after transmitting the ultrasonic waves, so that a blood vessel is positioned by transmitting and receiving double point-by-point focusing images, and an ultrasonic image of the blood vessel is displayed on the data image display system 86; after positioning, the distances of the first convex lens 72, the second convex lens 73 and the third convex lens 74 are adjusted through the first slide rail 751 and the second slide rail 752 so as to shape the light beams, and the first laser 2 forms a focus point after the laser light beams generated by the signal generator 1 (optionally, the laser light beams are indicated by green laser light generated by the second laser 4 (optionally, the second laser 4 is a 561nm laser)) enter the laser focusing holes (the laser light beams can be focused by the lenses) of the skin contactor 87 along the first light transmission channel 61; when target cells (such as circulating tumor cells, blood cells, lymphocytes and other cells in blood) in a circulatory system (such as target cells in skin tissue) pass through a focusing point of a laser beam, the target cells are irradiated by high-frequency pulse laser with different wavelengths to generate photoacoustic echoes, and the plurality of ultrasonic wave collection units 83 (optionally, the data acquisition system 85 sends instructions to the plurality of ultrasonic wave collection units 83 to receive ultrasonic waves) receive the photoacoustic echoes; the data acquisition system 85 sequentially filters, amplifies, time gain compensates, and converts the detected ultrasonic signals, and quantitatively analyzes (counts) the number of cells passing through the high-frequency pulse laser beam at the focus point of the blood vessel in unit time, and the processed data is displayed on the data image display system 86 in real time. Thus, on the basis of a living body fluorescence detection method, the photoacoustic effect of the biological tissue is combined, and the defects that the fluorescence marker interferes the physiological environment of the biological tissue and generates cytotoxicity to normal blood cells and lymphocytes are overcome; 【2】 The kit can realize non-invasive detection, does not need to draw blood or mark, can monitor in real time in vivo (living), has the advantages of in vivo and real time monitoring, and can detect patients for a long time; 【3】 The deep penetrability of ultrasonic waves is utilized to position blood vessels, and the photoacoustic specificity of biological tissues is utilized to accurately detect circulating cells, particularly circulating tumor cells; 【4】 The ultrasonic probe 81 transmits ultrasonic waves through more than two array elements, and receives echoes by using the array elements in the current aperture after transmitting the ultrasonic waves, so that the purpose of transmitting and receiving double point-by-point focusing images to position blood vessels is realized; the data acquisition and processing system regulates and controls the frequency of the array elements on the ultrasonic probe 81 to realize the double functions of positioning blood vessels and receiving photoacoustic echoes; 【5】 The data image display system 86 integrates an ultrasound image display system and a signal display system, and can display both the blood vessel image information and the circulating cell signal information.

Specifically, in one embodiment, the ultrasound probe 81 is 30 MHz.

Specifically, in one embodiment, the first laser 2 is a 1064nm pulse laser with a pulse energy of 100 μ J, a pulse time of 10ns, and a pulse frequency of 0.09 MHz.

Referring to fig. 1, as a cell detection method provided by the present invention, S1, a skin contactor is brought into contact with the skin of a user; s2, the ultrasonic probe emits at least two ultrasonic waves to the skin contacted with the skin contactor and collects the reflected ultrasonic waves; s3, the laser device emits laser beam with preset wavelength and focuses on the skin contacted with the skin contactor; and collecting ultrasonic waves generated from the skin irradiated with the laser beam by an ultrasonic wave collecting unit outside the laser beam. Thus, the skin contactor 87 is in contact with the skin, the ultrasonic probe 81 emits ultrasonic waves to the skin contactor 87 and the skin, and the ultrasonic probe 81 collects the reflected ultrasonic waves to perform ultrasonic examination on the skin; the user can obtain an ultrasonic image according to ultrasonic examination, then emits a laser beam through a laser device and focuses the laser beam on a position to be detected on the skin, when the laser beam irradiates on a predetermined cell, the surface of the predetermined cell is heated and expanded to generate ultrasonic waves, the ultrasonic waves are collected by the plurality of ultrasonic wave collecting units 83, and the user can obtain an ultrasonic signal of the predetermined cell through the ultrasonic waves collected by the plurality of ultrasonic wave collecting units 83.

Referring to fig. 1, a data acquisition system 85 collects the ultrasonic waves received by a plurality of the ultrasonic wave collection units 83 and calculates the number of cells with a predetermined frequency spectrum; the data image display system 86 shows that the data acquisition system has acquired a predetermined number of spectral cells. In this manner, the data acquisition system 85 separates cells (e.g., cancer cells) having a predetermined frequency spectrum from the frequency spectrum collected by the plurality of ultrasound collection units 83, counts the number of cells, and displays the number of cells on the data image display system 86 (e.g., a display) to inform the user.

The above description is only exemplary of the present invention and should not be taken as limiting the scope of the present invention, as any modifications, equivalents, improvements and the like made within the spirit and principles of the present invention are intended to be included within the scope of the present invention.

Claims

1. Cell detection apparatus, characterized in that it comprises: the skin contact device comprises a skin contact device used for contacting with the skin of a user, an ultrasonic probe used for emitting at least two ultrasonic waves towards the skin contacted with the skin contact device and collecting the ultrasonic waves, a laser device used for emitting a laser beam with a preset wavelength and focusing on the skin contacted with the skin contact device, and a plurality of ultrasonic wave collecting units arranged on the ultrasonic probe and positioned outside the laser beam.

2. The cell detection apparatus of claim 1, wherein the skin contact is a wrist band.

3. The cell detection apparatus according to claim 1, wherein the operating frequency of the ultrasonic probe is 1-50 MHz; the working frequency of the ultrasonic wave collecting unit is 50-100 MHz.

4. The cell inspection apparatus according to claim 2, further comprising a data acquisition system for collecting the ultrasonic waves received by the plurality of ultrasonic wave collection units and calculating the number of cells having a predetermined spectrum, and an image display system for displaying the data acquired by the data acquisition system to the number of cells having the predetermined spectrum.

5. The cell detection apparatus according to claim 1, wherein the laser device includes a first laser for emitting a laser beam of a predetermined wavelength, a first optical transmission channel for transmitting the laser beam, a second laser for generating an indicator beam, and a second optical transmission channel for transmitting the indicator beam; the downstream of the second optical transmission path meets and coincides with the downstream of the first optical transmission path.

6. The cell detection apparatus according to claim 5, wherein a dichroic mirror for transmitting the laser light beam and reflecting the indicator light beam is provided at an intersection of the second light transmission channel and the first light transmission channel.

7. The cell detection apparatus according to claim 5, wherein a plurality of the ultrasonic wave collection units are arranged around the first optical transmission channel.

8. The cell detection apparatus according to claim 7, wherein a laser probe is provided at an end of the first optical transmission channel, a plurality of the ultrasonic wave collection units are arranged along a circular ring-shaped path, and the laser probe is located at a center of the circular ring-shaped path.