CN1116938A - Extraction of Rhizoma Drynariae active principle - Google Patents
Extraction of Rhizoma Drynariae active principle Download PDFInfo
- Publication number
- CN1116938A CN1116938A CN 94111121 CN94111121A CN1116938A CN 1116938 A CN1116938 A CN 1116938A CN 94111121 CN94111121 CN 94111121 CN 94111121 A CN94111121 A CN 94111121A CN 1116938 A CN1116938 A CN 1116938A
- Authority
- CN
- China
- Prior art keywords
- rhizoma drynariae
- extraction
- active ingredient
- organic solvent
- lipid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Abstract
The Chinese medicinal material Rhizoma Drynariae is processed through water decoction, organic solvent extraction or reflux to obtain its active component. It is used in preventing and curing the toxic by-effect of amino-carbohydrate antibiotic, promoting hair growth, promoting bone regeneration and reinforcing kidney. It is prepared into injecta, liniment, pill or tablet, and without any toxic by-effect.
Description
The present invention relates to the extraction of Chinese medicine Rhizoma Drynariae active ingredient.
Rhizoma Drynariae is a kind of Chinese medicine, presses the theoretical kidney-reinforcing drug that belongs to of Chinese medicine, up to the present, its active ingredient is not extracted as yet be applied to clinical.
The purpose of this invention is to provide and a kind ofly can be applied to clinical, better efficacy, use the extracting method of Rhizoma Drynariae active ingredient more easily and its clinical practice.
The object of the present invention is achieved like this:
The extracting method of Rhizoma Drynariae active ingredient may further comprise the steps:
1) add 5-20 times of water in Rhizoma Drynariae, heating decocts 1-3 time;
2) filter, filtrate is concentrated into flowing soaking paste;
3) use fluid extract: the alcohols of organic solvent=1: 5~15 volume ratios, lipid, ketone, the active ingredient of alkanes organic solvent extraction.
The present invention can also realize by following steps:
Use Rhizoma Drynariae: organic solvent=1: the alcohols of 5-15 weight ratio, lipid, ketone, the distillation of alkanes organic solvent reflux were extracted in 0.5-1 hour.
The active ingredient that above step is extracted has following feature:
On the silica gel column chromatography plate with positive six alkane: acetone: having Rf value after ethanol=7.5: 7: 0.1 launches is 0.5-0.3; And has a ultra-violet absorption speckle more than 4.
This active ingredient has following pharmacological action after deliberation:
1). the effect of paying of control Aminoglycoside antibiotics;
Prove that in the guinea pig zoopery use gentamycin to use the animal of Rhizoma Drynariae working substance injection again simultaneously, the damage of its cochlear hair cell and hearing impairment obviously are lighter than and accept the gentamycin group merely.To the epithelial damage of the nearly curved tube of kidney, the Rhizoma Drynariae working substance shows the repair after significant protective effect and the damage.
The application of Rhizoma Drynariae extract does not change gentamycin haemoconcentration in animal body.Do not influence the antibacterial effect of gentamycin yet.
2). promote hair regeneration;
3). promote inostosis;
4). treatment nephropathy and enhancing renal function.
Above extract can be made into injection type, tablet form, pill-type medicine, also can be made into the liquid dosage form medicine for external application.
This extract is easy to use, and good effect is nontoxic, have no side effect.
Embodiment 1:
1). Rhizoma Drynariae 50g, add water 500ml and boil and fry in shallow oil 0.5 hour;
2). filter, steam to flowing soaking paste;
3). with 95% ethanol 20ml, extracted 10 minutes;
4). make injection type.
Be applied to prevent and treat the toxic and side effects of antibiotics.
Embodiment 2:
Rhizoma Drynariae 20g, with 95% ethanol 200ml, cohobation 0.5 hour.
Filter, get the Rhizoma Drynariae active ingredient, make liquid and be coated with dosage form outward, be applied to prevent and treat alopecia, promote hair regeneration.
Claims (3)
1. the extraction of Rhizoma Drynariae active ingredient is characterized in that may further comprise the steps:
1). add 5-20 times of water in Rhizoma Drynariae, heating decocts 1-3 time;
2). filter, filtrate is concentrated into flowing soaking paste;
3). use fluid extract: the alcohols of organic solvent=1: 5~15 volume ratios, lipid, ketone, the active ingredient of alkanes organic solvent extraction.
2. the extraction of Rhizoma Drynariae active ingredient is characterized in that with 1: 5-15 times of alcohols, and lipid, ketone, the distillation of alkanes organic solvent reflux was extracted in 0.5-1 hour.
3. according to the extraction of claim 1 or 2 described Rhizoma Drynariae active ingredients, it is characterized in that active ingredient has following feature: on the silica gel column chromatography plate with positive six alkane: acetone: having Rf value after ethanol equals to launch at 7.5: 7: 0.1 is 0.5-0.3; And uv absorption mottle more than four arranged.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 94111121 CN1116938A (en) | 1994-08-18 | 1994-08-18 | Extraction of Rhizoma Drynariae active principle |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 94111121 CN1116938A (en) | 1994-08-18 | 1994-08-18 | Extraction of Rhizoma Drynariae active principle |
Publications (1)
Publication Number | Publication Date |
---|---|
CN1116938A true CN1116938A (en) | 1996-02-21 |
Family
ID=5035021
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 94111121 Pending CN1116938A (en) | 1994-08-18 | 1994-08-18 | Extraction of Rhizoma Drynariae active principle |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1116938A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002053164A1 (en) * | 2000-12-29 | 2002-07-11 | Qihuang Pharmaceutical Technology And Investment Co., Ltd. | Drynaria extractions for treating osteoporosis and their extraction process |
-
1994
- 1994-08-18 CN CN 94111121 patent/CN1116938A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002053164A1 (en) * | 2000-12-29 | 2002-07-11 | Qihuang Pharmaceutical Technology And Investment Co., Ltd. | Drynaria extractions for treating osteoporosis and their extraction process |
US7122214B2 (en) | 2000-12-29 | 2006-10-17 | Qihuang Pharmaceutical Technology And Investment Co., Ltd. | Drynaria extractions for treating osteoporosis and their extraction process |
CN100418521C (en) * | 2000-12-29 | 2008-09-17 | 北京岐黄制药有限公司 | Gusuibu extracts for trvating osteoporosis and method for extracting same |
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PB01 | Publication | ||
C01 | Deemed withdrawal of patent application (patent law 1993) | ||
WD01 | Invention patent application deemed withdrawn after publication |