CN1116905C - Quinoketone sterilizing inflammation diminishing and stanch bleeding gauze - Google Patents
Quinoketone sterilizing inflammation diminishing and stanch bleeding gauze Download PDFInfo
- Publication number
- CN1116905C CN1116905C CN95115433A CN95115433A CN1116905C CN 1116905 C CN1116905 C CN 1116905C CN 95115433 A CN95115433 A CN 95115433A CN 95115433 A CN95115433 A CN 95115433A CN 1116905 C CN1116905 C CN 1116905C
- Authority
- CN
- China
- Prior art keywords
- gauze
- quinoketone
- sterilizing
- inflammation diminishing
- stanch bleeding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 206010061218 Inflammation Diseases 0.000 title claims abstract description 6
- 230000000740 bleeding effect Effects 0.000 title claims abstract description 6
- 230000004054 inflammatory process Effects 0.000 title claims abstract description 6
- 230000001954 sterilising effect Effects 0.000 title claims description 10
- 230000003467 diminishing effect Effects 0.000 title claims description 4
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 5
- 239000003814 drug Substances 0.000 claims abstract description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 15
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 claims description 8
- 150000007660 quinolones Chemical class 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- 239000003463 adsorbent Substances 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 5
- 230000002439 hemostatic effect Effects 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- 238000009835 boiling Methods 0.000 claims description 4
- 229960003405 ciprofloxacin Drugs 0.000 claims description 4
- 239000002270 dispersing agent Substances 0.000 claims description 4
- IDYZIJYBMGIQMJ-UHFFFAOYSA-N enoxacin Chemical compound N1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNCC1 IDYZIJYBMGIQMJ-UHFFFAOYSA-N 0.000 claims description 3
- GSDSWSVVBLHKDQ-UHFFFAOYSA-N 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=C2)=O)=C3N2C(C)COC3=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-UHFFFAOYSA-N 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 229960002549 enoxacin Drugs 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 229960001699 ofloxacin Drugs 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims 2
- 230000001741 anti-phlogistic effect Effects 0.000 claims 2
- 229960001180 norfloxacin Drugs 0.000 claims 1
- OGJPXUAPXNRGGI-UHFFFAOYSA-N norfloxacin Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNCC1 OGJPXUAPXNRGGI-UHFFFAOYSA-N 0.000 claims 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 206010052428 Wound Diseases 0.000 abstract description 5
- 208000027418 Wounds and injury Diseases 0.000 abstract description 5
- 241000894006 Bacteria Species 0.000 abstract description 4
- 238000002360 preparation method Methods 0.000 abstract description 4
- 229940079593 drug Drugs 0.000 abstract description 2
- 230000001681 protective effect Effects 0.000 abstract 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 230000003110 anti-inflammatory effect Effects 0.000 description 6
- 238000004659 sterilization and disinfection Methods 0.000 description 6
- 230000023597 hemostasis Effects 0.000 description 4
- 241000193830 Bacillus <bacterium> Species 0.000 description 3
- 206010040943 Skin Ulcer Diseases 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 238000001804 debridement Methods 0.000 description 3
- 238000010992 reflux Methods 0.000 description 3
- 231100000019 skin ulcer Toxicity 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- -1 Polyethylene Polymers 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 229920001214 Polysorbate 60 Polymers 0.000 description 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000588923 Citrobacter Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241001360526 Escherichia coli ATCC 25922 Species 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 206010021531 Impetigo Diseases 0.000 description 1
- 241000192041 Micrococcus Species 0.000 description 1
- 241000588769 Proteus <enterobacteria> Species 0.000 description 1
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 1
- 241000607715 Serratia marcescens Species 0.000 description 1
- IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 description 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
- 201000005010 Streptococcus pneumonia Diseases 0.000 description 1
- 241000193998 Streptococcus pneumoniae Species 0.000 description 1
- 241000193996 Streptococcus pyogenes Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 102000011759 adducin Human genes 0.000 description 1
- 108010076723 adducin Proteins 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229940021231 clearskin Drugs 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 238000006266 etherification reaction Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 239000006101 laboratory sample Substances 0.000 description 1
- 229960003511 macrogol Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
Abstract
The present invention discloses soluble broad-spectrum antibacterial medical gauze for clearing wounds, relieving inflammation and stopping bleeding, and a preparation method thereof. The preparation method comprises the step of absorbing a right amount of synthesized quinoketone anti-microorganism medicines on soluble staltic gauze to obtain a kind of medical gauze. The gauze has the functions of widely resisting bacteria, clearing sores, relieving inflammation and stopping bleeding, and is used as an antibacterial protective dressing on wounds and operative incisions.
Description
The present invention relates to a kind of medicine and preparation method thereof.Be particularly related to a kind of a kind of sterilization, antiinflammatory, stop blooding and gauze of certain debridement effect and preparation method thereof is arranged based on quinolones.
Existing hemostatic material soluble stanching gauze, the gelatin foam of stanch fibre, absorbable stanching satin and import.A limitation is in use all arranged---promptly can not be used to have and infect and the suppurative wound place.But infect wound in daily life or itself be that impetigo that pathogenic bacteria causes is then more to be seen more.Like this, a kind of gauze filling with sterilization, antiinflammatory, hemostasis and clear multiple function of skin ulcer covers various wounds, works the product of curing the disease and protecting double effects, has just become to have the problem of researching value.
An object of the present invention is on the basis of soluble stanching gauze, be processed into the quinolones germ killing drugs and a kind ofly have and to mix with blood, the gauze with sterilization, antiinflammatory, hemostasis, clear multiple function of skin ulcer that can be absorbed by body fluid.
Another object of the present invention provides a kind of quinolones sterilization, antiinflammatory, hemostasis, clear skin ulcer and can dissolve the manufacture method that absorbs gauze for body fluid.
Another purpose of the present invention provides a kind of quinolones and is adsorbed in a kind of method on the soluble stanching gauze.It is become a kind ofly can dissolve the gauze that absorbs and have sterilization, antiinflammatory, debridement for body fluid.
The objective of the invention is to realize by following method;
The present invention uses quinolones under the effect of solvent, adsorbent and dispersant, quinolones is adsorbed onto on the soluble stanching gauze quantitatively, obtains a kind of have sterilization, antiinflammatory, hemostasis and debridement and can be dissolved a kind of multi-functional gauze of absorption in the human body.
Described solvent comprises liquid alcohols (methanol, ethanol, propanol etc.) and water, acetone.Certainly other solvent that can be used for method for making of the present invention is also included within the solution of the present invention.
Described adsorbent comprises propylene glycol, glycerol, liquid polyethylene glycol, 12-18 carbon higher fatty acids, tetradecyl alchohol, hexadecanol and octadecanol.Certainly, other adsorbent that can reach the object of the invention is also included among the present invention.
Described dispersant comprises TWEEN-40, SPAN-40, TWEEN-60 and SPAN-60.
Technical scheme details of the present invention comprises:
In an anti-corrosion reaction vessel, add solvent, the Macrogol 600 that adds solvent gross weight 5-10% again, the Tween-40 of 1-4% (or Tween-60), the glycerol of 3-7% (or propylene glycol) mixing post-heating, put into and put the soluble stanching gauze cold, that degree of etherification falling is higher after little the boiling of quinolones (as enoxacin, ciprofloxacin etc.) and put into and soaked 4-12 hour, back reheat is to boil (the hemostatic gauze consumption is total liquid measure 2-20%), backflow 5-40 minute, drain fabric, get product with hot blast drying.
Laboratory sample of the present invention carries out the test of pesticide effectiveness through delivering Inst. of Medicinal Biological Technology, Chinese Academy of Medical Sciences, and antimicrobial spectrum result is as follows: MIG mg/ml streptococcus pneumonia 3 16 the same 64 16 micrococcus scarlatinaes, 556 32 gold medal Portugal bacterium, the 556 4 bacterium ATCC25923 of gold medal Portugal, 4 form staphs, 25 4 hay bacillus ATCC6633,1 micrococcus catarrhalises 238 16 of the husky star hemostatic gauze of test organisms
Escherichia coli 22 0.25
Escherichia coli ATCC25922 0.12
Bacillus pyocyaneus ATCC27853 8
Bacillus pyocyaneus 17 2
Bacillus proteus 91
Bacterium morgani 19 0.5
Pneumobacillus 14 0.25
Bacillus typhi 901 0.12
Fu Shi dysentery bacillus 0.25
Citrobacter 2 32
Serratia marcescens 41,002 4
Sample of the present invention as can be seen from the above table has broad-spectrum antibacterial action.Consider it is in the future that body local is used, its site of action valid density can be several times as much as this number, and effect is gratifying.
Below further specify invention method for making and product again by embodiment again.
Embodiment 1:
In the 250ml flask, add methanol 60ml, 95% ethanol 60ml, Polyethylene Glycol-400,4ml, glycerol 5m1, Tween-40,4ml shakes up heating, put into ciprofloxacin 1.5 grams again, soluble stanching gauze 3-4 gram, boiling reflux 30 minutes, cooling, the above-mentioned gauze of waterloging out, pressing dry the back is finished product with the hair-dryer oven dry.
Embodiment 2:
In the 250ml flask, add 95% ethanol 120ml, Polyethylene Glycol-600,6ml, glycerol 6ml, Tween-60,3 grams, shake up, add ciprofloxacin 1 gram, heat is to little boiling, put into 3 gram soluble stanching gauzes after cold, soaked 6 hours, and put into reflux again and carried out reflux 20 minutes, above-mentioned gauze dry the product that press dry, dries is taken out in cooling back.
Embodiment 3:
With embodiment 2.Just dosing makes ofloxacin into.All the other are with embodiment 2.
Claims (4)
1, a kind of Quinoketone sterilizing inflammation diminishing and stanch bleeding gauze is characterized in that based on soluble stanching gauze, a kind of bactericidal antiphlogistic hemostatic gauze that forms in conjunction with the Comprecin of last effective dose.
2, bactericidal antiphlogistic hemostatic gauze according to claim 1 is characterized in that used quinolones is enoxacin, norfloxacin, ciprofloxacin and ofloxacin.
3, a kind of method of making Quinoketone sterilizing inflammation diminishing and stanch bleeding gauze, it is characterized in that making solvent with liquid alcohol, under the effect of adsorbent and dispersant soak at room temperature 4-12 hour, reheat was to boiling, backflow 5-40 minute, quinolone medicine is adsorbed onto on the soluble stanching gauze quantitatively.
4, method according to claim 3 is characterized in that used adsorbent is liquid polyethylene glycol and/or glycerol, and used dispersant is medicinal non-ionic surface active agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95115433A CN1116905C (en) | 1995-09-14 | 1995-09-14 | Quinoketone sterilizing inflammation diminishing and stanch bleeding gauze |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95115433A CN1116905C (en) | 1995-09-14 | 1995-09-14 | Quinoketone sterilizing inflammation diminishing and stanch bleeding gauze |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1145258A CN1145258A (en) | 1997-03-19 |
| CN1116905C true CN1116905C (en) | 2003-08-06 |
Family
ID=5080480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN95115433A Expired - Lifetime CN1116905C (en) | 1995-09-14 | 1995-09-14 | Quinoketone sterilizing inflammation diminishing and stanch bleeding gauze |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1116905C (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1111072C (en) * | 1996-08-02 | 2003-06-11 | 高景星 | Body-compatible antiseptic and antiphlogitic bleeding-stopping dressing and its prepn |
| DE19962470A1 (en) * | 1999-12-22 | 2001-07-12 | Schulz Hans Herrmann | Use of chemotherapy drugs |
| CN101269235B (en) * | 2008-05-21 | 2011-06-22 | 高景星 | Novel soluble antimicrobial anti-inflammation hemostatic cotton fibre and its preparation method |
| CN103405805A (en) * | 2013-05-24 | 2013-11-27 | 海安县美佳卫生用品有限公司 | Manufacturing method of anti-inflammatory and antimicrobial hemostatic gauze |
| CN103397509A (en) * | 2013-08-07 | 2013-11-20 | 武汉纺织大学 | Preparation method for antibacterial liquid-absorbing gauze |
| CN108837175A (en) * | 2018-07-23 | 2018-11-20 | 衢州玛济克医疗科技有限公司 | A kind of debridement medical dressing and its production method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1081103A (en) * | 1992-09-19 | 1994-01-26 | 蒋明威 | Preparation capable of permeating skin of quinolone containing class medicine and preparation method thereof |
-
1995
- 1995-09-14 CN CN95115433A patent/CN1116905C/en not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1081103A (en) * | 1992-09-19 | 1994-01-26 | 蒋明威 | Preparation capable of permeating skin of quinolone containing class medicine and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1145258A (en) | 1997-03-19 |
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Owner name: SHINE(QING DAO) PROPERTY CO., LTD. Free format text: FORMER OWNER: GAO JINGXI Owner name: NONE Free format text: FORMER OWNER: GAO JINGXING; XU HONGZHANG Effective date: 20031022 |
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| TR01 | Transfer of patent right |
Effective date of registration: 20031022 Address after: North City of Shandong province Qingdao City Road 266002 No. 87 Patentee after: Saint Oriole (Qingdao) properties Ltd Address before: 475001 apple garden and river house, Kaifeng, Henan Co-patentee before: Gao Jingxing Patentee before: Gao Jingxi Co-patentee before: Xu Hongzhang |
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| C57 | Notification of unclear or unknown address | ||
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Addressee: Saint Oriole (Qingdao) properties Ltd Document name: Notice of conformity |
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| EXPY | Termination of patent right or utility model |