CN111685322A - Composition for promoting gastric digestion and health-care product and application thereof - Google Patents

Composition for promoting gastric digestion and health-care product and application thereof Download PDF

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CN111685322A
CN111685322A CN202010558699.9A CN202010558699A CN111685322A CN 111685322 A CN111685322 A CN 111685322A CN 202010558699 A CN202010558699 A CN 202010558699A CN 111685322 A CN111685322 A CN 111685322A
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parts
powder
dried
fried
composition
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黄远英
张铭辉
谭佳威
殷光玲
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BY Health Co Ltd
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734Crataegus (hawthorn)
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
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    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9068Zingiber, e.g. garden ginger
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    • A61K9/20Pills, tablets, discs, rods
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    • A61K9/2022Organic macromolecular compounds
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Abstract

The invention discloses a composition for promoting gastric digestion, and a health-care product and application thereof. The composition comprises the following components: radix Codonopsis, parched Atractylodis rhizoma, parched fructus Hordei Germinatus, pericarpium Citri Tangerinae, Zingiberis rhizoma, brewing yeast powder, and fructus crataegi slurry powder. The invention selects the codonopsis pilosula, the fried bighead atractylodes rhizome, the fried malt, the dried orange peel, the dried ginger, the brewing yeast powder and the hawthorn pulp powder as raw materials, has homology of medicine and food and has high edible safety. Experiments prove that the components have synergistic interaction, the stomach digestion is effectively promoted, the intestinal flora is adjusted, the constipation problem caused by food retention is improved, and the intestines and the stomach are simultaneously conditioned.

Description

Composition for promoting gastric digestion and health-care product and application thereof
Technical Field
The invention belongs to the field of health care products, and particularly relates to a composition for promoting gastric digestion, a health care product and application thereof.
Background
Modern people have irregular diet, greasy taste, coldness, acridity and too fast, are compensated to drink, overeat, have high working and living pressure, and are easy to cause discomfort symptoms such as gastrectasia, abdominal distension, indigestion and the like due to environmental factors, genetic factors and the like. The uncomfortable symptoms are called Functional Dyspepsia (FD) in modern medicine, and belong to the categories of epigastric pain, fullness, epigastric upset and the like in traditional Chinese medicine.
FD refers to digestive dysfunction symptoms derived from gastroduodenal diseases, i.e., persistent or recurrent epigastric pain, abdominal distension, early satiety, belching, anorexia, acid regurgitation, nausea, vomiting, etc., and can exclude organic, systemic, metabolic diseases that may explain the symptoms, and the course of disease is generally defined as more than one month or more than twelve weeks in a month, which is a common functional gastrointestinal disease. In recent years, the rate of FD pathogenic population is increased year by year, and the incidence rate of FD population in Europe and America is 19% -41%, and the average incidence rate is 32%; the content of the active ingredients in the domestic is 18-45 percent, and the active ingredients account for 20-40 percent of the digestion clinic. FD not only affects the quality of life of the patient, but also constitutes a considerable medical expense.
Western medicine FD is mainly used for symptomatic treatment, such as promotion of gastric motility, protection of gastric mucosa, inhibition of gastric acid secretion, helicobacter pylori resistance and the like, and the Western medicine treatment effect is not obvious because FD causes and pathogenesis are not clear and clinical symptoms are repeated. In recent years, a great number of experimental researches are carried out by combining the basic theory of traditional Chinese medicine with clinical practice of a plurality of medical students, and the result proves that the basic formula of the traditional Chinese medicine has obvious curative effect of FD addition and subtraction treatment and is obviously superior to the treatment of western medicines.
Disclosure of Invention
In view of the above, the primary object of the present invention is to provide a composition for promoting gastric digestion, wherein the components in the composition have synergistic effects and have an effective effect of promoting gastric digestion.
The invention is realized by the following technical scheme;
a composition for promoting gastric digestion comprising the components: radix Codonopsis, parched Atractylodis rhizoma, parched fructus Hordei Germinatus, pericarpium Citri Tangerinae, Zingiberis rhizoma, brewing yeast powder, and fructus crataegi slurry powder.
The raw materials of the invention are reported as follows:
codonopsis pilosula: codonopsis pilosula (Codonopsispilosula) is one of the commonly used clinical tonifying herbs. Codonopsis pilosula belongs to Campanulaceae, has sweet taste and mild nature, enters spleen and lung meridians, and has effects of invigorating spleen and replenishing qi, promoting fluid production and regulating stomach. Dangshen is indicated for spleen-lung deficiency, qi and blood deficiency, tiredness and weakness in clinic because it is sweet and neutral but not dry and greasy, and commonly used prescriptions are sijunzi decoction, eight-treasure decoction, and shiquan dabu pill, etc. Radix Codonopsis contains various chemical components, such as terpenes, sugar and glycosides, steroids, flavonoids, lignan glycosides, coumarins, alkaloids, volatile oil, organic acids, amino acids, etc. The codonopsis pilosula is one of effective traditional Chinese medicines for regulating the functions of the spleen and the stomach, and has multiple effects on the digestive system.
Frying the bighead atractylodes rhizome: the white atractylodes rhizome is the dried rhizome of white atractylodes rhizome (Atractyly-lodes macrocephala Koidz) of Compositae, is mainly used for tonifying spleen qi clinically, has warm nature, sweet taste and slight pungent and bitter taste, has the functions of strengthening spleen and tonifying qi, eliminating dampness and promoting diuresis, stopping sweating and preventing miscarriage, and is used for treating diseases such as spleen deficiency, anorexia, abdominal distention and diarrhea, phlegm and fluid retention, dizzy palpitation, edema, spontaneous perspiration, threatened abortion and the like. Atractylodis rhizoma mainly contains volatile oil, atractylenolide, polysaccharide, and glycosides. Atractylodes macrocephala lactone I, II and III are anti-inflammatory effective components, and Atractylodes macrocephala volatile oil and Atractylodes macrocephala lactone III have anticancer effect.
And (3) malt frying: the fructus Hordei Germinatus is prepared from mature fruit of Gramineae fructus Hordei vulgaris (Hordeum vulgare L.) by germinating and drying, and has sweet taste and spleen and stomach meridian tropism; has effects in promoting qi circulation, resolving food stagnation, invigorating spleen, stimulating appetite, invigorating qi, tonifying deficiency, and relieving breast distention; it can be used for treating dyspepsia, abdominal pain, spleen deficiency, anorexia, breast pain, and breast pain. From Ben Cao gang mu, it is said that it is effective in promoting digestion, regulating the middle warmer, breaking cold air, removing heart and abdominal distention. In the treatise of the herb Property, it is said that it "digests food, breaks cold air, and removes fullness in the heart and abdomen". Malt is a commonly used group digestant used to promote digestion of starchy foods. The fructus Hordei Germinatus contains amylase, invertase, esterase, protease, phospholipid, vitamin B, vitamin C, maltose, glucose, and maltodextrins. Starch is decomposed into maltose and dextrin under the action of enzyme, the dextrin can be decomposed into maltose by the enzyme, the maltose is beneficial to absorption by organisms, and the amylase contained in the malt is one of the main components for promoting digestion.
Dried orange peel: the pericarpium Citri Tangerinae is dry mature pericarp of Rutaceae plant fructus Citri Tangerinae (Citrus reticulate Blanco) and its cultivar, is pungent, bitter and warm in taste, enters spleen and lung channels, and has effects of regulating qi-flowing, invigorating spleen, eliminating dampness and eliminating phlegm. The functional value of tangerine peel is recorded in the Ming dynasty Li Shizhen Ben Cao gang mu, which records the functions of eliminating phlegm, lowering qi, promoting the production of body fluid, stimulating the appetite, strengthening the spleen and stomach, and detoxifying and soothing the nerves. Ming dynasty plum-Shizhenyun: "tonics are tonifying, purgatives are purging, ascending and descending. Spleen is the mother of original qi and lung is the label for qi absorption, so orange peel is the herb for qi system of two meridians, but it can tonify and purge ascending and descending along with the recipe. In China, the Chinese medicine holds that the orange peel is better as the orange peel is older, so the orange peel is called as the tangerine peel. "Chenpi" is mainly used for treating digestive system and respiratory system diseases, is the most commonly used medicine for treating digestive tract diseases such as esophagus, stomach and duodenum, etc., and can be used for treating abdominal distension, belch, vomiting, constipation or diarrhea, etc. The pericarpium Citri Tangerinae mainly contains volatile oil, flavonoids, polysaccharides, organic amines and microelements, and has effects of increasing blood pressure, resisting platelet aggregation, resisting oxidation, resisting aging, resisting bacteria, resisting allergy, resisting tumor, killing parasite, and promoting digestion.
Dried ginger: zingiberis rhizoma is dried rhizome of Zingiber officinale Roscoe of Zingiberaceae, and has pungent taste and mild nature. It enters lung, spleen and stomach meridians. Has the effects of relieving exterior syndrome, dispelling cold, warming middle energizer, relieving vomiting, warming lung, relieving cough, and removing toxic substance. Can be used for treating wind-cold type common cold, spleen and stomach cold syndrome, stomach cold emesis, cough due to lung cold, and fish and crab toxin relieving.
Brewing yeast powder: saccharomyces cerevisiae, also known as baker's yeast or budding yeast. Saccharomyces cerevisiae is the most widely related yeast to human, not only because it is traditionally used for making bread, steamed bread and other food and brewing wine, but also as a eukaryotic model organism in modern molecular and cellular biology, and its function is equivalent to prokaryotic model organism Escherichia coli. Saccharomyces cerevisiae is the most commonly used biological species in fermentation. The saccharomyces cerevisiae is a concentrated bank of natural nutrients and is rich in protein, a plurality of B vitamins, dietary fiber and a plurality of mineral elements. The brewing yeast powder mainly acts in stomach, duodenum, small intestine and cecum to promote digestion.
Hawthorn pulp powder: the fructus crataegi is dry mature fruit of Crataegus pinnatifida Bgevar majorn.E.Br. or Crataegus pinnatifida Bge. of Rosaceae, and has mild nature, sour and sweet taste, and can enter spleen, stomach and liver channels. Has effects of resolving food stagnation, invigorating stomach, activating qi-flowing, removing blood stasis, eliminating turbid pathogen and reducing blood lipid, and can be used for treating meat food stagnation, gastric cavity distention, dysentery abdominal pain, blood stasis amenorrhea, puerperal blood stasis, heart and abdomen stabbing pain, thoracic obstruction, cardialgia, hernia pain, and hyperlipidemia. The charred fructus crataegi has enhanced effect in promoting digestion and resolving food stagnation, and can be used for treating food stagnation and dysentery. The fructus crataegi mainly contains cellulose, tannin, triterpenes, flavonoids, flavane and its polymer, organic acids, and steroids. Has effects in regulating blood lipid, protecting liver, lowering blood pressure, promoting digestion, tonifying heart, resisting oxidation, resisting tumor, and inhibiting bacteria.
Fructus crataegi contains VC and VB2Carrot and various organic acids, and can increase the secretion of digestive enzyme in stomach, enhance the activity of enzyme and promote digestion. The hawthorn contains pepsin agonist which can enhance the activity of protease; in addition, the food also contains amylase, which can enhance the activity of pancreatic lipase, and achieve the effects of promoting digestion, stimulating appetite and promoting appetite.
The invention takes radix codonopsitis, fried bighead atractylodes rhizome, fried malt, dried orange peel, dried ginger, brewing yeast powder and hawthorn pulp powder as raw materials, wherein the radix codonopsitis is a monarch drug for tonifying middle-jiao and Qi, strengthening spleen and nourishing stomach; stir-baked white atractylodes rhizome, rhizoma atractylodis macrocephalae is used for removing dampness and promoting digestion, tonifying qi and promoting diuresis, and mediating middle energizer is used as the minister; the hawthorn pulp powder is used for eliminating food stagnation, especially eliminating food stagnation caused by greasy meat; the roasted malt eliminates rice and food retention, the dried orange peel regulates qi and stomach, and the dried orange peel also serves as a guiding drug; the brewing yeast powder can promote digestion and eliminate stagnation, and can be used for enhancing the digestion promoting effect of the product under the synergistic effect with other components. The medicines are combined to play the effects of strengthening spleen and stomach, removing food retention and removing food stagnation.
As a preferred embodiment, the composition for promoting gastric digestion comprises the following components in parts by weight: 10-40 parts of codonopsis pilosula, 10-40 parts of fried bighead atractylodes rhizome, 10-40 parts of fried malt, 10-40 parts of dried orange peel, 2-10 parts of dried ginger, 5-20 parts of brewing yeast powder and 5-20 parts of hawthorn pulp powder.
In a preferred embodiment, the composition for promoting gastric digestion is prepared from the following components in parts by weight: 20 parts of codonopsis pilosula, 15 parts of fried bighead atractylodes rhizome, 15 parts of fried malt, 15 parts of dried orange peel, 7 parts of dried ginger, 5 parts of brewing yeast powder and 5-20 parts of hawthorn pulp powder.
The invention also provides application of the composition in preparing a health-care product for promoting gastric digestion.
The invention also provides a health-care product for promoting gastric digestion, which is prepared from the composition and acceptable auxiliary materials in the health-care product according to the conventional method in the field.
The dosage form of the health care product can be tablets, capsules, powder, granules, pills or oral liquid and the like, and preferably tablets.
Suitable excipients may be isomalt, D-mannitol, microcrystalline cellulose, crospovidone, silicon dioxide, magnesium stearate, anhydrous citric acid, acesulfame potassium, steviol glycosides and the like in amounts conventional in the art.
As a preferred embodiment of the present invention, the tablet comprises the following components in parts by weight:
10-40 parts of codonopsis pilosula, 10-40 parts of fried bighead atractylodes rhizome, 10-40 parts of fried malt, 10-40 parts of dried orange peel, 2-10 parts of dried ginger, 5-20 parts of brewing yeast powder, 5-20 parts of hawthorn pulp powder, 5-20 parts of beta-cyclodextrin, 20-50 parts of isomalt, 2-15 parts of mannitol, 2-15 parts of microcrystalline cellulose, 2-10 parts of anhydrous citric acid, 0.1-2 parts of acesulfame potassium, 0.1-1 part of stevioside, 2-10 parts of crospovidone, 1-5 parts of silicon dioxide and 1-5 parts of magnesium stearate.
The invention also provides a preparation method of the tablet, which comprises the following steps:
(1) weighing: weighing the medicinal materials of codonopsis pilosula, dried orange peel, fried bighead atractylodes rhizome, fried malt and dried ginger according to the formula ratio for later use; crushing the anhydrous citric acid, screening the crushed anhydrous citric acid by a 60-mesh screen, and weighing for later use; sieving potassium acetylsulfanilate and stevioside by 40 meshes, and weighing for later use; other materials are agglomerated and pass through a 40-mesh screen;
(2) extracting and concentrating: adding weighed medicinal materials into an extraction tank, extracting with water for 1-2 times, filtering the extractive solution, and mixing
Filtering the filtrate, taking the extracted filtrate, performing suction filtration, and recovering and concentrating the filtrate after suction filtration to obtain a concentrated solution;
(3) spray drying and granulating: adding beta-cyclodextrin into the concentrated solution, mixing, heating, stirring, spray drying, and collecting
Spraying dry powder, and passing the sprayed dry powder through a 20-mesh screen in an extrusion manner to obtain spray-dried particles;
(4) total mixing: the anhydrous citric acid, the acesulfame potassium, the stevioside, the crospovidone and the spray drying are added according to the formula amount
Adding granule, brewing yeast powder, fructus crataegi powder, isomalt, mannitol, microcrystalline cellulose, and silicon dioxide into a mixer, mixing for 20-30min, adding magnesium stearate, mixing for 5-10min, mixing, discharging, and tabletting.
In the preparation method of the tablet, beta-cyclodextrin is used during spray drying, so that the peculiar smell of the traditional Chinese medicine can be embedded, and in addition, the hawthorn pulp powder is added to ensure that the taste of the final product is better.
Compared with the prior art, the invention has the following beneficial effects:
the invention combines the traditional theory and the modern research, selects the codonopsis pilosula, the fried bighead atractylodes rhizome, the fried malt, the dried orange peel, the dried ginger, the brewing yeast powder and the hawthorn pulp powder as the raw materials, has homology of medicine and food, and has high edible safety. Experiments prove that the components have synergistic interaction, the stomach digestion is effectively promoted, the intestinal flora is adjusted, the constipation problem caused by food retention is improved, and the intestines and the stomach are simultaneously conditioned.
Detailed Description
The present invention is further illustrated by the following specific embodiments, which are not intended to limit the scope of the invention.
The raw materials adopted in the embodiment of the invention are all from commercial products.
Example 1: efficacy test
1.1 test groups are shown in Table 1:
table 1: combination 1-combination 6 formula
Figure 336468DEST_PATH_IMAGE002
2.2 Effect test:
2.2.1 test methods
The test was conducted on the animal body weight, body weight gain, food intake and food utilization rate, small intestine exercise test, and digestive enzyme assay in accordance with "test for digestive function promotion test method" in "test and evaluation of health food" (2003 edition).
2.2.1.1 dose selection
The dose is calculated as 60kg for adult human body weight, 1200 mg/tablet, 2 times a day, 3 tablets each time, and is converted to 120mg/kg BW according to the recommended human body dosage of the sample. 2400mg/kg BW (equivalent to 20 times of the recommended dose in human body) was set, a negative control group was set for the digestive enzyme assay, and a negative control group and a constipation model group (model control group) were set for the small intestine exercise test. Weighing 24.0g of each combined sample, adding pure water to 100mL, dissolving and uniformly mixing to prepare 240 mg/mL solution for rat experiments; weighing 24.0g of each combined sample, adding pure water to 200 mL, dissolving and uniformly mixing to prepare a solution with the concentration of 120 mg/mL for mouse experiments. The gavage amount of the rat is 1.0 mL/100 g BW, and the gavage amount of the mouse is 0.2 mL/100 g BW.
2.2.1.2 test procedure
Body weight, weight gain, food intake and food availability experiments: selecting rats, performing intragastric administration, measuring the weight and food intake of animals for 2 times per week, and calculating the food utilization rate.
Small intestine exercise test: mice were selected and gavaged once a day. After the experiment, the animals in each group were fasted overnight without water inhibition for 16 hours, and each combination sample solution was administered 30 minutes later, the compound diphenoxylate solution was administered 30 minutes later, and the ink was administered 30 minutes later. After 25 minutes, the animals were sacrificed and the abdominal cavity was opened, and the total length of the small intestine and the ink propulsion length were measured. And calculating the ink propelling rate.
And (3) digestive enzyme determination: rats were selected and gavaged once a day. Fasting was not prohibited for 24 hours before the end of the experiment. Gastric juice discharged within 3 hours was collected by a pyloric ligation method of ether-anesthetized rats, and the amount of gastric juice per unit time was measured. Gastric fluid was taken to calculate pepsin activity and pepsin output.
2.2.1.3 test data processing
The experimental data processing is carried out statistical processing by variance analysis; but if the experimental data has irregular variance, the statistical analysis of the rank sum test is used instead. The data of the food utilization rate and the ink propulsion rate are firstly converted according to the following formula:
Figure DEST_PATH_IMAGE003
,wherein P is the food utilization rate and the ink propulsion rate, expressed in decimal, and then subjected to anova.
2.2.2 test result determination
2.2.2.1 comparing the experimental group of weight, weight gain, food intake and food utilization rate with the negative control group, the difference of any index of the three indexes of weight, weight gain and food intake is significant after statistical treatment, and the food utilization rate is not obviously reduced compared with the negative control group, so that the test result can be judged to be positive.
2.2.2.2 the small intestine movement test, on the premise that the model is established, the ink propulsion rate is increased by comparing the experimental group with the model group, the difference is significant through statistical treatment, and the test result can be judged to be positive.
2.2.2.3 compared with the negative control group, the test group for digestive enzyme has increased index of gastric fluid volume, pepsin activity and pepsin output, and the difference is significant by statistical treatment, so that the test result is positive.
2.2.2.4 the comprehensive results show that the test is positive if any two of the weight, weight gain, food intake and food utilization rate, small intestine exercise test and digestive enzyme test are positive, and the product has digestion promoting function.
2.2.3 the results of the tests are shown in tables 2-5:
TABLE 2 weight and body weight gain test results
Figure DEST_PATH_IMAGE005
As can be seen from the table above, the weights of rats in the experimental groups and the negative control group are close to each other at the beginning of the experiment, and the differences are not significant (P is more than 0.05), which indicates that the weights of animals in the groups before the experiment are relatively balanced. At the end of the test, the weight gain of the rats in each formula experiment is higher than that of the negative control group, but the weight gain of the rats is not significant (P is more than 0.05) compared with that of the negative control group, which indicates that each formula has no obvious promotion effect on the weight gain of the rats.
Table 3 food intake and food utilization experimental results
Figure DEST_PATH_IMAGE007
As can be seen from the table above, the food intake and the food utilization rate of the rats in each formula are higher than those of the negative control group, but the difference between each dose group and the negative control group is not significant (P is more than 0.05), which indicates that each formula has no obvious influence on the food intake and the food utilization rate of the rats.
TABLE 4 digestive enzyme assay results
Figure DEST_PATH_IMAGE009
As can be seen from the above table: the gastric juice amount, pepsin activity and pepsin output of each group of the formula are higher than those of a negative control group. The difference between the gastric juice amount, the pepsin activity and the pepsin output of the formulas 1-4 and the negative control group is not significant (P is more than 0.05). The difference between the amount of gastric juice, the activity of pepsin and the output of pepsin of the group formulas 5-6 and the negative control group is significant (P is less than 0.01). The formula 5-6 has the effects of improving the gastric juice amount, the pepsin activity and the pepsin output of rats, and the formula 6 has a better effect.
TABLE 5 results of the intestinal motility test
Figure DEST_PATH_IMAGE011
As can be seen from the above table: the Chinese ink propulsion rate of each group of the formula is higher than that of a model control group. Through data conversion and statistical analysis, the ink propulsion rate of the formula 1-4 has no significant difference (P is more than 0.05) with the difference of a model control group. The differences between the formulas 5-6 and the model control group are all significant (P is less than 0.01). The results show that the formula 5-6 has the function of promoting the small intestine movement of constipation mice, and the formula 6 has better effect.
2.2.4 evaluation of results
The components of the composition provided by the invention are synergistic, the pepsin activity, the gastric juice amount and the pepsin output of a rat can be improved, the small intestine movement of a constipated mouse can be promoted, and the composition has an obvious digestion promoting function.
Example 2: preparation of tablets
A tablet for promoting gastric digestion comprises the following components in parts by weight:
20 parts of codonopsis pilosula, 15 parts of fried bighead atractylodes rhizome, 15 parts of fried malt, 15 parts of dried orange peel, 7 parts of dried ginger, 5 parts of brewing yeast powder, 5 parts of hawthorn pulp powder, 5 parts of beta-cyclodextrin, 10 parts of isomaltitol, 3 parts of mannitol, 2 parts of microcrystalline cellulose, 1 part of anhydrous citric acid, 0.1 part of acesulfame potassium (acesulfame potassium), 0.0.5 parts of stevioside, 1.5 parts of crospovidone, 0.5 part of silicon dioxide and 0.5 part of magnesium stearate.
The preparation process comprises the following steps:
1) weighing: weighing the medicinal materials of codonopsis pilosula, dried orange peel, fried bighead atractylodes rhizome, fried malt and dried ginger according to the formula ratio for later use. Crushing the anhydrous citric acid, screening the crushed anhydrous citric acid by a 60-mesh screen, and weighing for later use; sieving acesulfame potassium (acesulfame potassium) and stevioside with 40 mesh sieve, and weighing; accurately weighing other materials according to the dosage of each batch for later use (the materials are agglomerated and pass through a 40-mesh screen);
2) extraction: adding the weighed medicinal materials into an extraction tank, extracting for 2 times, filtering the extract, and combining the filtrates for later use;
3) concentration: taking the filtrate extracted twice, carrying out suction filtration, and recovering and concentrating the filtrate in a single-effect external circulation concentrator after suction filtration;
4) spray drying and granulating: adding beta-cyclodextrin into the concentrated solution, uniformly mixing, heating, stirring, performing spray drying, collecting spray-dried powder, and extruding the spray-dried powder through a 20-mesh screen by using an oscillating granulator to obtain spray-dried particles;
5) total mixing: adding anhydrous citric acid, acesulfame potassium (acesulfame potassium), stevioside, crospovidone, spray-dried granules, brewing yeast powder, hawthorn pulp powder, isomalt, mannitol, microcrystalline cellulose and silicon dioxide into a mixer, mixing for 25min, then adding magnesium stearate, mixing for 8min, and discharging after mixing uniformly;
6) tabletting: 1200 mg/tablet, controlling the tablet weight range, and checking the appearance of the tablet at any time;
and (5) inspecting, bottling and warehousing.

Claims (8)

1. A composition for promoting gastric digestion comprising the components: radix Codonopsis, parched Atractylodis rhizoma, parched fructus Hordei Germinatus, pericarpium Citri Tangerinae, Zingiberis rhizoma, brewing yeast powder, and fructus crataegi slurry powder.
2. The composition for promoting gastric digestion according to claim 1, which comprises the following components in parts by weight:
10-40 parts of codonopsis pilosula, 10-40 parts of fried bighead atractylodes rhizome, 10-40 parts of fried malt, 10-40 parts of dried orange peel, 2-10 parts of dried ginger, 5-20 parts of brewing yeast powder and 5-20 parts of hawthorn pulp powder.
3. The composition for promoting gastric digestion according to claim 2, which is characterized by comprising the following components in parts by weight:
20 parts of codonopsis pilosula, 15 parts of fried bighead atractylodes rhizome, 15 parts of fried malt, 15 parts of dried orange peel, 7 parts of dried ginger, 5 parts of brewing yeast powder and 5 parts of hawthorn pulp powder.
4. Use of a composition according to any one of claims 1 to 3 in the preparation of a health product for promoting gastric digestion.
5. A health product for promoting gastric digestion, which is characterized by being prepared from the composition as claimed in any one of claims 1 to 3 and auxiliary materials acceptable in the health product.
6. The health product according to claim 5, wherein the dosage form of the health product is tablet, capsule, powder, granule, pill or oral liquid, preferably tablet.
7. The health product of claim 6, wherein the tablet comprises the following components in parts by weight:
10-40 parts of codonopsis pilosula, 10-40 parts of fried bighead atractylodes rhizome, 10-40 parts of fried malt, 10-40 parts of dried orange peel, 2-10 parts of dried ginger, 5-20 parts of brewing yeast powder, 5-20 parts of hawthorn pulp powder, 5-20 parts of beta-cyclodextrin, 20-50 parts of isomalt, 2-15 parts of mannitol, 2-15 parts of microcrystalline cellulose, 2-10 parts of anhydrous citric acid, 0.1-2 parts of acesulfame potassium, 0.1-1 part of stevioside, 2-10 parts of crospovidone, 1-5 parts of silicon dioxide and 1-5 parts of magnesium stearate.
8. The health product of claim 7, wherein the preparation method of the tablet comprises the following steps:
(1) weighing: weighing the medicinal materials of codonopsis pilosula, dried orange peel, fried bighead atractylodes rhizome, fried malt and dried ginger according to the formula ratio for later use; crushing the anhydrous citric acid, screening the crushed anhydrous citric acid by a 60-mesh screen, and weighing for later use; sieving acesulfame potassium and stevioside with a 40-mesh sieve, and weighing for later use; other materials are agglomerated and pass through a 40-mesh screen;
(2) extracting and concentrating: adding weighed medicinal materials into an extraction tank, extracting with water for 1-2 times, filtering the extractive solution, and mixing
Filtering the filtrate, taking the extracted filtrate, performing suction filtration, and recovering and concentrating the filtrate after suction filtration to obtain a concentrated solution;
(3) spray drying and granulating: adding beta-cyclodextrin into the concentrated solution, mixing, heating, stirring, spray drying, and collecting
Spraying dry powder, and passing the sprayed dry powder through a 20-mesh screen in an extrusion manner to obtain spray-dried particles;
total mixing: adding anhydrous citric acid, acesulfame potassium, stevioside, crospovidone, spray-dried granules, brewing yeast powder, hawthorn pulp powder, isomalt, mannitol, microcrystalline cellulose and silicon dioxide into a mixer, mixing for 20-30min, adding magnesium stearate, mixing for 5-10min, discharging after mixing uniformly, and tabletting to obtain the finished product.
CN202010558699.9A 2020-06-18 2020-06-18 Composition for promoting gastric digestion and health-care product and application thereof Pending CN111685322A (en)

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