CN111671659A - Facial cleansing cream capable of efficiently cleansing face and preparation method thereof - Google Patents
Facial cleansing cream capable of efficiently cleansing face and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Abstract
The invention discloses a facial cleanser capable of efficiently cleaning faces and a preparation method thereof, wherein sodium cocoyl glycinate is added, the functions are mild and free of allergy, the facial cleanser can be used as an amino acid surfactant, when the facial cleanser is prepared, components such as glycerin, polyethylene glycol and the like are in synergistic action, the pH is controlled to be 5-6, the acidification degree of the sodium cocoyl glycinate is increased, and a system is crystallized, so that the finally prepared cream is fine in appearance, easy to extrude and apply, and excellent in crystallization temperature and stability. The application discloses facial cleanser capable of efficiently cleaning face and a preparation method thereof, the process design is reasonable, the component proportion is proper, the prepared facial cleanser is good in use condition, rich and fine in foam, clean, smooth, comfortable, free of stimulation, not greasy and not tight after face cleaning, excellent in antibacterial performance, capable of cleaning microorganisms on the surface of skin and good in practicability.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a facial cleansing cream capable of efficiently cleansing the face and a preparation method thereof.
Background
A facial cleanser, also called as cleansing cream, belongs to skin cleansing cosmetics, and aims to remove dirt on skin, make the skin fresh and cool and help to keep the normal physiological state of the skin. The object of cleansing with the cleansing cream is that sebum, fragments of the stratum corneum and their oxidative decomposition products, which adhere to the skin surface, and residues of cosmetic makeup, which stick together, are unstable, react with oxygen or deposited molecules in the air, and undergo various physicochemical and biochemical reactions upon exposure to sunlight or the presence of bacteria on the skin, forming substances that may harm the skin.
In daily life, pores of facial skin of people are easy to block and irritate, dry skin is easy to generate tight feeling and dull, people with oily skin adsorb redundant dead skin and dirt due to excessive secretion of grease, so that the pores are blocked, and in addition, residue caused by incomplete daily makeup removal is generated.
In order to solve the problem, a facial cleansing cream capable of efficiently cleansing the face and a preparation method thereof are provided, which are technical problems to be solved urgently.
Disclosure of Invention
The invention aims to provide a facial cleanser capable of efficiently cleaning faces and a preparation method thereof, and aims to solve the problems in the prior art.
In order to achieve the purpose, the invention provides the following technical scheme:
the facial cleanser capable of efficiently cleaning the face comprises the following raw materials: 10-20 parts of glycerol, 1-2 parts of polyethylene glycol, 5-8 parts of sodium cocoyl glycinate, 10-15 parts of sorbitol, 5-8 parts of disodium ethylene diamine tetraacetate, 2-4 parts of cocoyl diethanolamine, 5-7 parts of sodium methyl cocoyl taurate, 0.5-1 part of humectant, 0.1-0.3 part of preservative and 0.1-0.5 part of essence.
According to an optimized scheme, the facial cleanser further comprises the following raw material components: 4-8 parts of first additive and 4-8 parts of second additive by weight.
According to a more optimized scheme, the raw materials of each component of the first additive comprise: by weight, 5-10 parts of carboxymethyl chitosan, 10-15 parts of n-octane, 0-12 parts of span-8010, 2-4 parts of glutaraldehyde, 2-3 parts of 3-aminopropyltriethoxysilane and 6-12 parts of silver nitrate.
According to a more optimized scheme, the second additive is prepared from activated carbon and a modifier, and the activated carbon is prepared from bamboo and pyrophosphoric acid.
In a more optimized scheme, the modifier is any one or a mixture of tetradecyltrimethylammonium chloride, hexadecyltrimethylammonium chloride and octadecyltrimethylammonium chloride.
According to an optimized scheme, the preparation method of the facial cleansing cream capable of efficiently cleansing the face comprises the following steps:
1) preparing materials;
2) preparing a first additive:
a) dissolving carboxymethyl chitosan in deionized water, and stirring to obtain a chitosan solution;
b) taking n-octane and span-80, stirring, heating to 45-50 ℃, adding a chitosan solution, emulsifying for 30-40min, adding glutaraldehyde, crosslinking and curing, after the reaction is finished, cleaning with acetone, cleaning with absolute ethyl alcohol, cleaning with deionized water, and drying in vacuum to obtain a material A;
c) mixing 3-aminopropyltriethoxysilane with deionized water, heating to 45-48 ℃, stirring, adding the material A, continuing stirring, adding a silver nitrate solution, continuing stirring, cleaning and drying to obtain a first additive;
3) preparing a second additive:
a) soaking bamboo in distilled water for 1-2 days, naturally air drying, pulverizing, vacuum drying, placing in pyrophosphoric acid, stirring, soaking, heating to 460 deg.C, carbonizing, cooling, washing to neutrality, drying at 105 deg.C, pulverizing, and sieving with 100 mesh sieve to obtain activated carbon;
b) putting activated carbon into a modifier, heating to 20-25 ℃, reacting for 2-2.5h, centrifugally separating, washing to be neutral, crushing, sieving with a 400-mesh sieve, and vacuum drying to obtain a second additive;
4) taking glycerol and polyethylene glycol, stirring, slowly adding water, and stirring until the materials are dissolved to obtain a material B;
5) placing sodium cocoyl glycinate, sorbitol, disodium ethylene diamine tetraacetate, cocoyl diethanol amine and sodium methyl cocoyl taurate in a water bath at the temperature of 80-90 ℃, stirring, adding a first additive, stirring at the temperature of 70-80 ℃, adding a material B and a second additive, continuously stirring, adding citric acid, adjusting the pH value to 5-6, stirring, adding a humectant, a preservative and essence, stirring, cooling and placing to obtain the cleansing cream.
The optimized scheme comprises the following steps:
1) preparing materials;
2) preparing a first additive:
a) dissolving carboxymethyl chitosan in deionized water, and stirring for 10-20min to obtain chitosan solution;
b) taking n-octane and span-80, stirring for 10-15min, heating to 45-50 ℃, adding a chitosan solution, emulsifying for 30-40min, adding glutaraldehyde, curing for 4-5h, after the reaction is finished, cleaning with acetone for 10-15min, cleaning with absolute ethyl alcohol for 5-10min, cleaning with deionized water for 5-8min, and vacuum drying to obtain a material A;
c) mixing 3-aminopropyltriethoxysilane with deionized water, heating to 45-48 ℃, stirring for 4-5h, adding the material A, continuing to stir for 5-8h, adding a silver nitrate solution, continuing to stir for 1-2h, cleaning and drying to obtain a first additive;
3) preparing a second additive:
a) preparing active carbon;
b) putting activated carbon into a modifier, heating to 20-25 ℃, reacting for 2-2.5h, centrifugally separating, washing to be neutral, crushing, sieving with a 400-mesh sieve, and vacuum drying at 50 ℃ to obtain a second additive;
4) stirring glycerol and polyethylene glycol for 10-15min, ultrasonically dispersing for 5-10min, slowly adding water, and stirring until the materials are dissolved to obtain a material B;
5) placing sodium cocoyl glycinate, sorbitol, disodium ethylene diamine tetraacetate, cocoyl diethanolamine and sodium methyl cocoyl taurate in a water bath at 80-90 ℃, stirring for 30-40min, adding a first additive, stirring for 20-30min at 70-80 ℃, adding a material B and a second additive, continuously stirring for 30-40min, adding citric acid, adjusting the pH value to 5-6, stirring for 20-30min, adding a humectant, a preservative and essence at 30-40 ℃, stirring for 20-30min, cooling and standing for 24-30h to obtain the cleansing cream.
In an optimized scheme, in the step a) of the step 3), the preparation method of the activated carbon comprises the following steps: soaking bamboo in distilled water for 1-2 days, naturally drying, pulverizing to 40 mesh, vacuum drying at 100 deg.C, drying, soaking in pyrophosphoric acid, stirring for 8-10h, heating to 460 deg.C, carbonizing, cooling, washing to neutrality, drying at 105 deg.C, pulverizing, and sieving with 100 mesh sieve to obtain activated carbon.
In an optimized scheme, in the step 4), the stirring speed is 60-70 r/min.
In an optimized scheme, in the step 5), the pH is adjusted to 5.8 by citric acid.
Compared with the prior art, the invention has the beneficial effects that:
in the step 2), the first additive is prepared, the carboxymethyl chitosan is modified by using 3-aminopropyltriethoxysilane, and in the process, the 3-aminopropyltriethoxysilane can perform bimolecular or multi-molecular polymerization per se to form a large amount of amino groups, the amino groups can react with carboxyl groups in the carboxymethyl chitosan to generate Si-O combined modification, and at the moment, the outer surface of the chitosan microsphere is coated with a large amount of amino groups; in the process, a silver nitrate solution is added, Ag + ions in the silver nitrate solution can not only perform a coordination reaction with amino groups, but also can react with carboxyl groups, so that a large amount of Ag + ions are adsorbed on the surfaces of the generated chitosan microspheres, and the obtained first additive is added into the cleansing cream, so that the cleansing cream can have excellent antibacterial and bacteriostatic properties, and the cleansing power of the cleansing cream is improved.
In the step 3), a second additive is prepared, bamboo and pyrophosphoric acid are carbonized at high temperature during preparation to prepare active carbon, wherein pyrophosphoric acid can be used as an active agent, the active carbon is modified by a modifier, long-chain alkyl end of quaternary ammonium salt can be loaded on the surface of the active carbon through hydrophobic effect, and nitrogen-containing positive charges are exposed, so that the surface of the active carbon has the nitrogen-containing positive charges; the preparation of the cleansing cream is carried out in the steps 4) and 5), in the preparation process, the pH is adjusted by citric acid to be 5-6, in the process, the residual amino groups on the surface of the chitosan microspheres of the first additive are protonated and have positive charges, and the first additive and the second additive have positive charges and can be mutually dispersed due to electrostatic interaction, so that the prepared cleansing cream has uniformly dispersed components, fine finished products and more excellent cleansing effect; meanwhile, the first additive and the second additive can generate synergistic action, dead skin and impurities on the surface of the skin are adsorbed by utilizing electrostatic action during skin cleaning, and the cleaning force of the facial cleanser is further improved.
The coconut oil acyl sodium glycinate is added, functions are mild and free of allergy, the coconut oil acyl sodium glycinate can be used as an amino acid surfactant, when the cleansing cream is prepared, components such as glycerin and polyethylene glycol are in synergistic effect, pH is controlled to be 5-6, the acidification degree of the coconut oil acyl sodium glycinate is increased, and a system is crystallized, so that the finally prepared cream is fine in appearance, easy to extrude and foam, and excellent in crystallization temperature and stability.
The application discloses facial cleanser capable of efficiently cleaning face and a preparation method thereof, the process design is reasonable, the component proportion is proper, the prepared facial cleanser is good in use condition, rich and fine in foam, clean, smooth, comfortable, free of stimulation, not greasy and not tight after face cleaning, excellent in antibacterial performance, capable of cleaning microorganisms on the surface of skin and good in practicability.
Detailed Description
The technical solutions in the examples of the present invention will be described clearly and completely below, and it is obvious that the described examples are only a part of examples of the present invention, but not all examples. All other examples, which can be obtained by a person skilled in the art without making any creative effort based on the examples in the present invention, belong to the protection scope of the present invention.
Example 1:
s1: preparing materials;
s2: preparing a first additive:
dissolving carboxymethyl chitosan in deionized water, and stirring for 10min to obtain chitosan solution;
taking n-octane and span-80, stirring for 10min, heating to 45 ℃, adding a chitosan solution, emulsifying for 30min, adding glutaraldehyde, curing for 4h, after the reaction is finished, cleaning with acetone for 10min, cleaning with absolute ethyl alcohol for 5min, cleaning with deionized water for 5min, and vacuum drying to obtain a material A;
mixing 3-aminopropyltriethoxysilane with deionized water, heating to 45 ℃, stirring for 4 hours, adding the material A, continuing to stir for 5 hours, adding a silver nitrate solution, continuing to stir for 1 hour, cleaning and drying to obtain a first additive;
s3: preparing a second additive:
soaking bamboo in distilled water for 1-2 days, air drying, pulverizing to 40 mesh, vacuum drying at 100 deg.C, drying, placing in pyrophosphoric acid, stirring and soaking for 8h, heating to 450 deg.C, carbonizing, cooling, washing to neutrality, drying at 100 deg.C, pulverizing, and sieving with 100 mesh sieve to obtain activated carbon;
putting activated carbon into a modifier, heating to 20 ℃, reacting for 2 hours, centrifugally separating, washing to be neutral, crushing, sieving with a 400-mesh sieve, and vacuum-drying at 50 ℃ to obtain a second additive;
s4: taking glycerol and polyethylene glycol, stirring for 10min at a stirring speed of 60r/min, ultrasonically dispersing for 5min, slowly adding water, and stirring until the materials are dissolved to obtain a material B;
s5: placing sodium cocoyl glycinate, sorbitol, disodium ethylene diamine tetraacetate, cocoyl diethanol amine and sodium methyl cocoyl taurate in a water bath at 80 ℃, stirring for 30min, adding a first additive, stirring for 20min at 70 ℃, then adding a material B and a second additive, continuously stirring for 30min, adding citric acid, adjusting the pH value to 5, stirring for 20min, adding a humectant, a preservative and essence at 30 ℃, stirring for 20min, cooling and placing for 24h to obtain the cleansing cream.
In the embodiment, the facial cleanser comprises the following raw materials: by weight, 10 parts of glycerol, 1 part of polyethylene glycol, 5 parts of sodium cocoyl glycinate, 10 parts of sorbitol, 5 parts of ethylene diamine tetraacetic acid, 2 parts of cocoyl diethanolamine, 5 parts of sodium methyl cocoyl taurate, 0.5 part of humectant, 0.1 part of preservative, 0.1 part of essence, 4 parts of first additive and 4 parts of second additive.
The first additive comprises the following raw materials in parts by weight: by weight, 5 parts of carboxymethyl chitosan, 10 parts of n-octane, 0 part of span-8010 part of glutaraldehyde, 2 parts of 3-aminopropyltriethoxysilane and 6 parts of silver nitrate. The modifier is tetradecyltrimethyl ammonium chloride.
Example 2:
s1: preparing materials;
s2: preparing a first additive:
dissolving carboxymethyl chitosan in deionized water, and stirring for 15min to obtain chitosan solution;
taking n-octane and span-80, stirring for 13min, heating to 48 ℃, adding a chitosan solution, emulsifying for 35min, adding glutaraldehyde, curing for 4.5h, after the reaction is finished, cleaning with acetone for 13min, cleaning with absolute ethyl alcohol for 8min, cleaning with deionized water for 7min, and vacuum drying to obtain a material A;
mixing 3-aminopropyltriethoxysilane with deionized water, heating to 46 ℃, stirring for 4.5h, adding the material A, continuing to stir for 7h, adding a silver nitrate solution, continuing to stir for 1.5h, cleaning and drying to obtain a first additive;
s3: preparing a second additive:
soaking bamboo in distilled water for 1.5 days, air drying, pulverizing to 40 mesh, vacuum drying at 100 deg.C, drying, placing in pyrophosphoric acid, stirring and soaking for 9h, heating to 455 deg.C, carbonizing, cooling, washing to neutrality, drying at 102 deg.C, pulverizing, and sieving with 100 mesh sieve to obtain activated carbon;
putting activated carbon into a modifier, heating to 23 ℃, reacting for 2.3h, centrifugally separating, washing to be neutral, crushing, sieving with a 400-mesh sieve, and vacuum-drying at 50 ℃ to obtain a second additive;
s4: taking glycerol and polyethylene glycol, stirring for 13min at the stirring speed of 65r/min, ultrasonically dispersing for 8min, slowly adding water, and stirring until the materials are dissolved to obtain a material B;
s5: placing sodium cocoyl glycinate, sorbitol, disodium ethylene diamine tetraacetate, cocoyl diethanol amine and sodium methyl cocoyl taurate in a water bath at 85 ℃, stirring for 35min, adding a first additive, stirring for 25min at 75 ℃, then adding a material B and a second additive, continuously stirring for 35min, adding citric acid, adjusting the pH value to 5.5, stirring for 25min, adding a humectant, a preservative and essence at 35 ℃, stirring for 25min, cooling, and standing for 28h to obtain the cleansing cream.
In the embodiment, the facial cleanser comprises the following raw materials: 15 parts of glycerol, 1.5 parts of polyethylene glycol, 7 parts of sodium cocoyl glycinate, 13 parts of sorbitol, 6 parts of disodium ethylenediamine tetraacetate, 3 parts of cocoyl diethanolamine, 6 parts of sodium methyl cocoyl taurate, 0.8 part of humectant, 0.2 part of preservative, 0.3 part of essence, 7 parts of first additive and 6 parts of second additive.
The first additive comprises the following raw materials in parts by weight: by weight, 8 parts of carboxymethyl chitosan, 13 parts of n-octane, 3 parts of span-8011 parts of glutaraldehyde, 2.5 parts of 3-aminopropyltriethoxysilane and 10 parts of silver nitrate. The modifier is hexadecyl trimethyl ammonium chloride.
Example 3:
s1: preparing materials;
s2: preparing a first additive:
dissolving carboxymethyl chitosan in deionized water, and stirring for 18min to obtain chitosan solution;
taking n-octane and span-80, stirring for 12min, heating to 49 ℃, adding a chitosan solution, emulsifying for 34min, adding glutaraldehyde, curing for 4.2h, after the reaction is finished, cleaning with acetone for 12min, cleaning with absolute ethyl alcohol for 9min, cleaning with deionized water for 7min, and vacuum drying to obtain a material A;
mixing 3-aminopropyltriethoxysilane with deionized water, heating to 46 ℃, stirring for 4.9h, adding the material A, continuing to stir for 7h, then adding a silver nitrate solution, continuing to stir for 1.8h, cleaning and drying to obtain a first additive;
s3: preparing a second additive:
soaking bamboo in distilled water for 2 days, air drying, pulverizing to 40 mesh, vacuum drying at 100 deg.C, drying, soaking in pyrophosphoric acid, stirring for 9h, heating to 458 deg.C, carbonizing, cooling, washing to neutrality, drying at 104 deg.C, pulverizing, and sieving with 100 mesh sieve to obtain activated carbon;
putting activated carbon into a modifier, heating to 24 ℃, reacting for 2.4 hours, centrifugally separating, washing to be neutral, crushing, sieving with a 400-mesh sieve, and vacuum-drying at 50 ℃ to obtain a second additive;
s4: stirring glycerol and polyethylene glycol for 14min at a stirring speed of 65r/min, ultrasonically dispersing for 8min, slowly adding water, and stirring until the materials are dissolved to obtain a material B;
s5: placing sodium cocoyl glycinate, sorbitol, disodium ethylene diamine tetraacetate, cocoyl diethanol amine and sodium methyl cocoyl taurate in water bath at 89 ℃, stirring for 38min, adding a first additive, stirring for 27min at 78 ℃, then adding a material B and a second additive, continuously stirring for 38min, adding citric acid, adjusting the pH value to 5.8, stirring for 28min, adding a humectant, a preservative and essence at 38 ℃, stirring for 28min, cooling, and standing for 29h to obtain the cleansing cream.
In the embodiment, the facial cleanser comprises the following raw materials: according to weight, 19 parts of glycerin, 1.8 parts of polyethylene glycol, 7 parts of sodium cocoyl glycinate, 14 parts of sorbitol, 7 parts of ethylene diamine tetraacetic acid, 3 parts of cocoyl diethanolamine, 6 parts of sodium methyl cocoyl taurate, 0.9 part of humectant, 0.2 part of preservative, 0.4 part of essence, 7 parts of first additive and 7 parts of second additive.
The first additive comprises the following raw materials in parts by weight: by weight, 9 parts of carboxymethyl chitosan, 14 parts of n-octane, 80111 parts of span-glutaraldehyde, 3 parts of 3-aminopropyltriethoxysilane and 11 parts of silver nitrate. The modifier is octadecyl trimethyl ammonium chloride.
Example 4:
s1: preparing materials;
s2: preparing a first additive:
dissolving carboxymethyl chitosan in deionized water, and stirring for 20min to obtain chitosan solution;
taking n-octane and span-80, stirring for 15min, heating to 50 ℃, adding a chitosan solution, emulsifying for 40min, adding glutaraldehyde, curing for 5h, after the reaction is finished, cleaning with acetone for 15min, cleaning with absolute ethyl alcohol for 10min, cleaning with deionized water for 8min, and vacuum drying to obtain a material A;
mixing 3-aminopropyltriethoxysilane with deionized water, heating to 48 ℃, stirring for 5 hours, adding the material A, continuing to stir for 5-8 hours, adding a silver nitrate solution, continuing to stir for 2 hours, cleaning and drying to obtain a first additive;
s3: preparing a second additive:
soaking bamboo in distilled water for 2 days, naturally air drying, pulverizing to 40 mesh, vacuum drying at 100 deg.C, drying, soaking in pyrophosphoric acid, stirring for 10h, heating to 460 deg.C, carbonizing, cooling, washing to neutrality, drying at 105 deg.C, pulverizing, and sieving with 100 mesh sieve to obtain activated carbon;
putting activated carbon into a modifier, heating to 25 ℃, reacting for 2.5 hours, centrifugally separating, washing to be neutral, crushing, sieving with a 400-mesh sieve, and vacuum-drying at 50 ℃ to obtain a second additive;
s4: taking glycerol and polyethylene glycol, stirring for 15min at a stirring speed of 70r/min, ultrasonically dispersing for 10min, slowly adding water, and stirring until the materials are dissolved to obtain a material B;
s5: placing sodium cocoyl glycinate, sorbitol, disodium ethylene diamine tetraacetate, cocoyl diethanol amine and sodium methyl cocoyl taurate in a water bath at 90 ℃, stirring for 40min, adding a first additive, stirring for 30min at 80 ℃, then adding a material B and a second additive, continuously stirring for 40min, adding citric acid, adjusting the pH value to 6, stirring for 30min, adding a humectant, a preservative and essence at 40 ℃, stirring for 30min, cooling and placing for 30h to obtain the cleansing cream.
In the embodiment, the facial cleanser comprises the following raw materials: by weight, 20 parts of glycerol, 2 parts of polyethylene glycol, 8 parts of sodium cocoyl glycinate, 15 parts of sorbitol, 8 parts of ethylene diamine tetraacetic acid, 4 parts of cocoyl diethanolamine, 7 parts of sodium methyl cocoyl taurate, 1 part of humectant, 0.3 part of preservative, 0.5 part of essence, 8 parts of first additive and 8 parts of second additive.
The first additive comprises the following raw materials in parts by weight: by weight, 10 parts of carboxymethyl chitosan, 15 parts of n-octane, 15 parts of span-8012 parts of glutaraldehyde 4 parts, 3 parts of 3-aminopropyltriethoxysilane and 12 parts of silver nitrate. The modifier is tetradecyltrimethyl ammonium chloride, hexadecyltrimethyl ammonium chloride and octadecyl trimethyl ammonium chloride according to the weight ratio of 1: 1: 1 and mixing.
Comparative example 1:
s1: preparing materials;
s2: preparing a second additive:
soaking bamboo in distilled water for 2 days, air drying, pulverizing to 40 mesh, vacuum drying at 100 deg.C, drying, soaking in pyrophosphoric acid, stirring for 9h, heating to 458 deg.C, carbonizing, cooling, washing to neutrality, drying at 104 deg.C, pulverizing, and sieving with 100 mesh sieve to obtain activated carbon;
putting activated carbon into a modifier, heating to 24 ℃, reacting for 2.4 hours, centrifugally separating, washing to be neutral, crushing, sieving with a 400-mesh sieve, and vacuum-drying at 50 ℃ to obtain a second additive;
s3: stirring glycerol and polyethylene glycol for 14min at a stirring speed of 65r/min, ultrasonically dispersing for 8min, slowly adding water, and stirring until the materials are dissolved to obtain a material B;
s4: placing sodium cocoyl glycinate, sorbitol, disodium ethylene diamine tetraacetate, cocoyl diethanolamine and sodium methyl cocoyl taurate in water bath at 89 ℃, stirring for 38min, adding the material B and the second additive, continuing stirring for 38min, adding citric acid, adjusting the pH value to 5.8, stirring for 28min, adding the humectant, the preservative and the essence at 38 ℃, stirring for 28min, cooling and placing for 29h to obtain the cleansing cream.
In the embodiment, the facial cleanser comprises the following raw materials: according to weight, 19 parts of glycerin, 1.8 parts of polyethylene glycol, 7 parts of sodium cocoyl glycinate, 14 parts of sorbitol, 7 parts of ethylene diamine tetraacetic acid, 3 parts of cocoyl diethanolamine, 6 parts of sodium methyl cocoyl taurate, 0.9 part of humectant, 0.2 part of preservative, 0.4 part of essence and 7 parts of second additive. The modifier is octadecyl trimethyl ammonium chloride.
Comparative example 2:
s1: preparing materials;
s2: stirring glycerol and polyethylene glycol for 14min at a stirring speed of 65r/min, ultrasonically dispersing for 8min, slowly adding water, and stirring until the materials are dissolved to obtain a material B;
s3: placing sodium cocoyl glycinate, sorbitol, disodium ethylene diamine tetraacetate, cocoyl diethanolamine and sodium methyl cocoyl taurate in 89 ℃ water bath, stirring for 38min, adding material B, continuing stirring for 38min, adding citric acid, adjusting pH to 5.8, stirring for 28min, adding humectant, preservative and essence at 38 ℃, stirring for 28min, cooling, and standing for 29h to obtain the facial cleanser.
In the embodiment, the facial cleanser comprises the following raw materials: according to weight, 19 parts of glycerin, 1.8 parts of polyethylene glycol, 7 parts of sodium cocoyl glycinate, 14 parts of sorbitol, 7 parts of ethylene diamine tetraacetic acid, 3 parts of cocoyl diethanolamine, 6 parts of sodium methyl cocoyl taurate, 0.9 part of humectant, 0.2 part of preservative and 0.4 part of essence.
Detection experiment 1:
the following tests were performed on the samples of the cleansing creams prepared in examples 1 to 4, comparative examples 1 to 2, and the commercially available ordinary cleansing cream, respectively:
1. and (3) heat resistance test: the samples are respectively placed in an incubator at 42 ℃, and are taken out after 30 days to be restored to room temperature for observing whether the layering phenomenon or the obvious character difference exists.
2. Cold resistance test: and respectively placing the samples in a low-temperature storage box at the temperature of-10 ℃, taking out the samples after 30 days, and recovering to room temperature to observe whether the layering phenomenon or the obvious character difference exists.
3. And (3) cycle testing: and (3) placing the sample in an incubator at 42 ℃ for 24h, then placing the sample in a low-temperature storage box at-10 ℃ for 24h, circulating the steps for 10 times, and recovering to room temperature to observe whether the layering phenomenon or the obvious character difference exists.
The results are shown in the following table:
4. and (3) testing the use effect:
50 experienced volunteers were selected and divided into 5 groups, and the cleansing cream samples prepared in examples 1 to 4 and the general cleansing cream were tested, respectively.
When in test, the cleansing cream is continuously used for one week and 2 times per day, and is scored according to the sensory experience of a user, and the average value is taken for settlement; the score was made at 10 points, and was made from 5 points of skin irritation, greasiness, smoothness, comfort, and tightness.
The results are shown in the following table:
| item | Example 1 | Example 2 | Example 3 | Example 4 | Common face cleaning cream |
| Skin irritation | 9.7 | 9.5 | 9.8 | 9.5 | 6.8 |
| Greasy feeling | 9.1 | 9.0 | 9.2 | 9.1 | 7.1 |
| Degree of smoothness | 9.3 | 9.2 | 9.3 | 9.2 | 7.2 |
| Comfort feeling | 9.7 | 9.5 | 9.6 | 9.5 | 6.9 |
| Sense of tightness | 9.6 | 9.5 | 9.6 | 9.5 | 6.3 |
5. And (3) testing the bacteriostatic activity:
taking an autoclaved common agar culture medium, cooling to about 50 ℃, uniformly mixing, spreading a plate while the plate is hot, pouring the plate into a culture dish with the diameter of 9cm, sucking 0.5mL of bacterial suspension (escherichia coli and staphylococcus aureus) after the culture medium in the plate is solidified, putting the bacterial suspension into the culture medium, and uniformly coating the bacterial suspension by using a coating rod.
Taking the facial cleansing cream prepared in the example 1-4, the facial cleansing cream prepared in the comparative example 1-2 and the common facial cleansing cream, dissolving in water to prepare a facial cleansing solution with the concentration of 0.1g/ml, respectively placing filter paper sheets in the facial cleansing solution for soaking for 20min, fishing out the filter paper sheets by using tweezers after bacterial suspension is coated, draining the liquid, placing the filter paper sheets in a culture medium, and placing 4 filter paper sheets in each culture dish. Then placing the mixture in a constant temperature incubator at 37 ℃ for 24h, respectively observing and measuring the diameter (mm) of the inhibition zone, and averaging the measured values.
The measurement results are shown in the following table:
and (4) conclusion: the facial cleansing cream prepared by the method has the advantages that the facial cleansing cream prepared by the method is good in service condition, rich and fine in foam, clean, smooth, comfortable, non-irritant, non-greasy and non-tight in feeling after face cleansing, and has excellent antibacterial performance, can clean microorganisms on the surface of skin, and is good in practicability.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative examples and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present examples are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Claims (10)
1. A facial cleansing cream capable of efficiently cleansing the face is characterized in that: the facial cleanser comprises the following raw materials: 10-20 parts of glycerol, 1-2 parts of polyethylene glycol, 5-8 parts of sodium cocoyl glycinate, 10-15 parts of sorbitol, 5-8 parts of disodium ethylene diamine tetraacetate, 2-4 parts of cocoyl diethanolamine, 5-7 parts of sodium methyl cocoyl taurate, 0.5-1 part of humectant, 0.1-0.3 part of preservative and 0.1-0.5 part of essence.
2. The facial cleansing cream as claimed in claim 1, wherein the facial cleansing cream has a facial cleansing effect which is characterized in that: the cleansing cream comprises the following raw material components: 4-8 parts of first additive and 4-8 parts of second additive by weight.
3. The facial cleansing cream as set forth in claim 2, wherein the facial cleansing cream has a facial cleansing effect which is characterized in that: the first additive comprises the following raw materials in parts by weight: by weight, 5-10 parts of carboxymethyl chitosan, 10-15 parts of n-octane, 0-12 parts of span-8010, 2-4 parts of glutaraldehyde, 2-3 parts of 3-aminopropyltriethoxysilane and 6-12 parts of silver nitrate.
4. The facial cleansing cream as set forth in claim 2, wherein the facial cleansing cream has a facial cleansing effect which is characterized in that: the second additive is prepared from activated carbon and a modifier, and the activated carbon is prepared from bamboo and pyrophosphoric acid.
5. The facial cleansing cream as set forth in claim 4, wherein the facial cleansing cream has a facial cleansing effect which is characterized in that: the modifier is one or more of tetradecyl trimethyl ammonium chloride, hexadecyl trimethyl ammonium chloride and octadecyl trimethyl ammonium chloride.
6. A preparation method of a facial cleansing cream capable of efficiently cleansing the face is characterized by comprising the following steps: the method comprises the following steps:
1) preparing materials;
2) preparing a first additive:
a) dissolving carboxymethyl chitosan in deionized water, and stirring to obtain a chitosan solution;
b) taking n-octane and span-80, stirring, heating to 45-50 ℃, adding a chitosan solution, emulsifying for 30-40min, adding glutaraldehyde, crosslinking and curing, after the reaction is finished, cleaning with acetone, cleaning with absolute ethyl alcohol, cleaning with deionized water, and drying in vacuum to obtain a material A;
c) mixing 3-aminopropyltriethoxysilane with deionized water, heating to 45-48 ℃, stirring, adding the material A, continuing stirring, adding a silver nitrate solution, continuing stirring, cleaning and drying to obtain a first additive;
3) preparing a second additive:
a) soaking bamboo in distilled water for 1-2 days, naturally air drying, pulverizing, vacuum drying, placing in pyrophosphoric acid, stirring, soaking, heating to 460 deg.C, carbonizing, cooling, washing to neutrality, drying at 105 deg.C, pulverizing, and sieving with 100 mesh sieve to obtain activated carbon;
b) putting activated carbon into a modifier, heating to 20-25 ℃, reacting for 2-2.5h, centrifugally separating, washing to be neutral, crushing, sieving with a 400-mesh sieve, and vacuum drying to obtain a second additive;
4) taking glycerol and polyethylene glycol, stirring, slowly adding water, and stirring until the materials are dissolved to obtain a material B;
5) placing sodium cocoyl glycinate, sorbitol, disodium ethylene diamine tetraacetate, cocoyl diethanol amine and sodium methyl cocoyl taurate in a water bath at the temperature of 80-90 ℃, stirring, adding a first additive, stirring at the temperature of 70-80 ℃, adding a material B and a second additive, continuously stirring, adding citric acid, adjusting the pH value to 5-6, stirring, adding a humectant, a preservative and essence, stirring, cooling and placing to obtain the cleansing cream.
7. The method for preparing a facial cleansing cream capable of efficiently cleansing the face according to claim 6, wherein the facial cleansing cream comprises the following steps: the method comprises the following steps:
1) preparing materials;
2) preparing a first additive:
a) dissolving carboxymethyl chitosan in deionized water, and stirring for 10-20min to obtain chitosan solution;
b) taking n-octane and span-80, stirring for 10-15min, heating to 45-50 ℃, adding a chitosan solution, emulsifying for 30-40min, adding glutaraldehyde, curing for 4-5h, after the reaction is finished, cleaning with acetone for 10-15min, cleaning with absolute ethyl alcohol for 5-10min, cleaning with deionized water for 5-8min, and vacuum drying to obtain a material A;
c) mixing 3-aminopropyltriethoxysilane with deionized water, heating to 45-48 ℃, stirring for 4-5h, adding the material A, continuing to stir for 5-8h, adding a silver nitrate solution, continuing to stir for 1-2h, cleaning and drying to obtain a first additive;
3) preparing a second additive:
a) preparing active carbon;
b) putting activated carbon into a modifier, heating to 20-25 ℃, reacting for 2-2.5h, centrifugally separating, washing to be neutral, crushing, sieving with a 400-mesh sieve, and vacuum drying at 50 ℃ to obtain a second additive;
4) stirring glycerol and polyethylene glycol for 10-15min, ultrasonically dispersing for 5-10min, slowly adding water, and stirring until the materials are dissolved to obtain a material B;
5) placing sodium cocoyl glycinate, sorbitol, disodium ethylene diamine tetraacetate, cocoyl diethanolamine and sodium methyl cocoyl taurate in a water bath at 80-90 ℃, stirring for 30-40min, adding a first additive, stirring for 20-30min at 70-80 ℃, adding a material B and a second additive, continuously stirring for 30-40min, adding citric acid, adjusting the pH value to 5-6, stirring for 20-30min, adding a humectant, a preservative and essence at 30-40 ℃, stirring for 20-30min, cooling and standing for 24-30h to obtain the cleansing cream.
8. The method for preparing a facial cleansing cream capable of efficiently cleansing the face according to claim 6, wherein the facial cleansing cream comprises the following steps: in the step a) of the step 3), the preparation method of the active carbon comprises the following steps: soaking bamboo in distilled water for 1-2 days, naturally drying, pulverizing to 40 mesh, vacuum drying at 100 deg.C, drying, soaking in pyrophosphoric acid, stirring for 8-10h, heating to 460 deg.C, carbonizing, cooling, washing to neutrality, drying at 105 deg.C, pulverizing, and sieving with 100 mesh sieve to obtain activated carbon.
9. The method for preparing a facial cleansing cream capable of efficiently cleansing the face according to claim 6, wherein the facial cleansing cream comprises the following steps: in the step 4), the stirring speed is 60-70 r/min.
10. The method for preparing a facial cleansing cream capable of efficiently cleansing the face according to claim 6, wherein the facial cleansing cream comprises the following steps: in step 5), citric acid adjusts the pH to 5.8.
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| CN111956731A (en) * | 2020-08-31 | 2020-11-20 | 上海珈凯生物科技有限公司 | Traditional Chinese medicine composition with anti-allergic effect and preparation method thereof |
| WO2022007341A1 (en) | 2020-07-06 | 2022-01-13 | Beiersdorf Ag | Face cleansing composition containing amino acid surfactants |
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