CN111670365A

CN111670365A - Cassette and fluid processing system including the same

Info

Publication number: CN111670365A
Application number: CN201980011195.0A
Authority: CN
Inventors: 山内拓史; 北本健
Original assignee: Enplas Corp
Current assignee: Enplas Corp
Priority date: 2018-01-31
Filing date: 2019-01-23
Publication date: 2020-09-15
Also published as: WO2019151070A1; JPWO2019151070A1; US20200353471A1

Abstract

The cartridge of the present invention comprises: a reservoir including a housing portion and an opening portion; and a cap body fitted into the opening of the reservoir. The opening of the reservoir has: a pressing region for pressing a part of the cap body toward a central axis of the cap body; and an open region where a pressing force toward a center axis of the cap body is smaller than the pressing region, the cap body having a first region that is pressed when located in the pressing region of the reservoir. When the first region is located in the pressing region and the through hole of the first region is closed, the fluid in the housing section is not discharged to the outside through the through hole, and when the through hole of the first region is opened from the closed state, the first region moves into the open region, and the fluid is discharged from the housing section to the outside through the through hole.

Description

Cassette and fluid processing system including the same

Technical Field

The invention relates to a cartridge and a fluid processing system comprising the same.

Background

Conventionally, when various fluids are examined and analyzed, a required amount of a sample is usually separated and collected from a container for storing the fluid (sample) by a pipette or the like, and injected into a sheet or an apparatus for analysis. Conventionally, there have been proposed devices capable of automatically separating and collecting a sample by a pipette or automatically injecting a sample into a sheet (for example, patent documents 1 and 2).

Documents of the prior art

Patent document

Patent document 1: japanese patent laid-open publication No. 2013-150634

Patent document 2: international publication No. 2013/088913

Disclosure of Invention

Problems to be solved by the invention

However, the analysis device described in patent document 1 or patent document 2 requires a device for sucking a sample into a pipette, a device for moving a pipette, and the like. In addition, in order to inject a plurality of samples or reagents into the sheet, a plurality of pipettes are required, and it is also necessary to control the plurality of pipettes. Therefore, there are the following problems: the apparatus is easily upsized and the cost is easily increased.

The present invention has been made in view of the above problems, and an object thereof is to provide a cartridge that can inject a fluid into a desired sheet or the like without using a large-sized device, and a fluid processing system including the cartridge.

Means for solving the problems

The present invention provides the following cartridge.

The box body includes: a reservoir including a housing portion for housing a fluid, and an opening portion disposed in a part of the housing portion and communicating the housing portion with an outside; and a cap body made of a flexible elastic body, fitted into the opening of the reservoir, having a columnar shape, and having a through hole substantially parallel to a central axis thereof, wherein in the case body, the opening of the reservoir has: a pressing region for pressing a part of the cap body toward a central axis of the cap body; and an open region that is pressed toward a central axis of the cap body by a pressing force smaller than the pressing region, wherein the cap body has a first region that is pressed toward the central axis of the cap body when the first region is located in the pressing region of the reservoir, and wherein an outer wall of the opening portion presses the first region toward the central axis of the cap body when the through hole of the first region is closed, the fluid in the housing portion is not discharged to the outside through the through hole, and wherein when the through hole of the first region is opened while the first region is moved into the open region, the fluid is discharged from the housing portion to the outside through the through hole.

The present invention also provides the following fluid treatment system.

The fluid processing system comprises: the box body; and a flow path sheet having an inlet into which an end portion of the cap body on a side opposite to a side facing the housing portion is inserted, wherein when the first region of the cap body of the cartridge is moved from the pressing region side of the reservoir into the open region, fluid is discharged from the housing portion to the flow path sheet side through the through hole of the cap body.

Effects of the invention

According to the present invention, a cartridge capable of injecting a fluid into a channel sheet or the like by a simple method can be configured without providing a device for driving a pipette or a device for transporting a sheet.

Drawings

Fig. 1 is an exploded perspective view of a cartridge according to an embodiment of the present invention.

Fig. 2A is a front view of a reservoir included in a cartridge according to an embodiment of the present invention, fig. 2B is a top view of the reservoir, fig. 2C is a bottom view of the reservoir, and fig. 2D is a side view of the reservoir.

Fig. 3A is a cross-sectional view of the reservoir shown in fig. 2C taken along line a-a, fig. 3B is a cross-sectional view of the reservoir shown in fig. 2C taken along line B-B, fig. 3C is a partial enlarged view of the region of the reservoir shown in fig. 2C enclosed by a dashed line, and fig. 3D is a partial enlarged view of the region of the reservoir shown in fig. 2B enclosed by a dashed line.

Fig. 4A is a perspective view of the upper surface side of the cap included in the case according to the embodiment of the present invention, fig. 4B is a perspective view of the bottom surface side of the cap, fig. 4C is a front view of the cap, fig. 4D is a plan view of the cap, fig. 4E is a cross-sectional view of the cap taken along line a-a shown in fig. 4D, and fig. 4F is a cross-sectional view of the cap taken along line B-B shown in fig. 4D.

Fig. 5 is an exploded perspective view of the fluid handling system of the first embodiment of the present invention.

Fig. 6 is a bottom view of the main body of the flow path sheet included in the fluid treatment system of fig. 5.

Fig. 7A is a cross-sectional view taken along line a-a of the fluid handling system shown in fig. 5, fig. 7B is a cross-sectional view taken along line B-B of the fluid handling system shown in fig. 5, and fig. 7A and 7B are views when the cassette is set in a closed state.

Fig. 8A is a cross-sectional view taken along line a-a of the fluid treatment system shown in fig. 5, fig. 8B is a cross-sectional view taken along line B-B of the fluid treatment system shown in fig. 5, and fig. 8A and 8B are views in a state where the spacer is removed.

Fig. 9A is a cross-sectional view taken along line a-a of the fluid handling system shown in fig. 5, fig. 9B is a cross-sectional view taken along line B-B of the fluid handling system shown in fig. 5, and fig. 9A and 9B are views when the cassette is set to the open state.

Fig. 10 is an exploded perspective view of a fluid treatment system according to a second embodiment of the present invention.

Fig. 11A is a perspective view of an auxiliary member included in the fluid treatment system of fig. 10, fig. 11B is a perspective view of the auxiliary member when viewed from another angle, fig. 11C is a plan view of the auxiliary member, and fig. 11D is a cross-sectional view taken along line a-a of fig. 11C.

Fig. 12A is a perspective view of the fluid handling system of fig. 10 before the cap is inserted into the auxiliary member, fig. 12B is a perspective view of the fluid handling system after the cap is inserted into the auxiliary member, fig. 12C is a plan view of the fluid handling system after the cap is inserted into the auxiliary member, and fig. 12D is a cross-sectional view taken along line a-a of fig. 12C.

Fig. 13 is a perspective view of the fluid treatment system of fig. 10 with the cassette closed.

Fig. 14A is a top view of the fluid treatment system shown in fig. 13, and fig. 14B is a cross-sectional view taken along line a-a of fig. 14A.

Fig. 15A is a perspective view of the case of the fluid processing system of fig. 10 in an open state, and fig. 15B is a cross-sectional view taken along line a-a in fig. 15A.

Fig. 16 is an exploded perspective view of a fluid treatment system according to a third embodiment of the present invention.

Fig. 17 is a bottom view of a main body of a flow path sheet included in the fluid treatment system of fig. 16.

Fig. 18A is a perspective view of the main body of the flow path sheet of the fluid processing system of fig. 16 on the side where the support portion is formed, fig. 18B is a plan view of the main body of the flow path sheet, and fig. 18C is a cross-sectional view taken along line a-a in fig. 18B.

Detailed Description

1. Box body

Next, a cartridge according to an embodiment of the present invention will be described in detail with reference to the drawings. For ease of understanding of the description, the dimensions or the dimensional ratios shown in the drawings may be different from the actual dimensions or dimensional ratios.

As shown in the exploded perspective view of fig. 1, a cartridge 100 according to an embodiment of the present invention includes: a reservoir 11 for receiving a fluid; a cap 12 fitted into an opening (not shown) disposed at the bottom of the liquid reservoir 11; and a lid portion 13 covering the liquid reservoir 11. However, the cartridge 100 may be circulated in a state where the cap body 12 or the lid portion 13 is detached from the reservoir 11.

In the case of the cartridge 100 of the present embodiment, when a fluid is stored in the reservoir 11 (hereinafter, this state is also referred to as a "closed state" of the cartridge 100), the cap 12 functions as a plug for an opening portion of the reservoir 11. On the other hand, when the fluid is taken out from the reservoir 11 (hereinafter, this state is also referred to as an "open state" of the cartridge 100), the through hole 120 of the cap 12 functions as a flow path. Hereinafter, each member constituting the cartridge 100 will be described in detail.

Fig. 2A shows a front view, fig. 2B shows a top view, fig. 2C shows a bottom view, and fig. 2D shows a side view of the reservoir 11. Fig. 3A is a sectional view of the reservoir 11 shown in fig. 2C taken along line a-a, fig. 3B is a sectional view of the reservoir 11 shown in fig. 2C taken along line B-B, fig. 3C is a partially enlarged view of a portion surrounded by a broken line in fig. 2C, and fig. 3D is a partially enlarged view of a portion surrounded by a broken line in fig. 2B.

The reservoir 11 of the present embodiment includes: three receiving portions 111, and three openings 112 respectively disposed at the bottom of each receiving portion 111. The shape of the reservoir 11 is not particularly limited as long as it can store a desired amount of fluid in the storage section 111, and may be, for example, a substantially rectangular parallelepiped shape or a cylindrical shape. The number of the storage portions 111 and the number of the openings 112 disposed in the reservoir 11 are not particularly limited, and may be appropriately selected according to the application of the cartridge 100. For example, a plurality of openings 112 may be disposed in one housing section 111. In the present embodiment, the shape of the three housing portions 111 and the shape of the three openings 112 are the same, but they may be different from each other.

In the present embodiment, the housing portion 111 of the liquid reservoir 11 is a substantially rectangular parallelepiped recess with a bottom. However, the shape of the housing section 111 is not particularly limited as long as it can house a desired amount of fluid, and may be, for example, a truncated pyramid-shaped, cylindrical, or truncated cone-shaped recess. In the present embodiment, the bottom surface of the housing portion 111 is set to be substantially parallel to the surface of the fluid to be housed, but a part or all of the bottom surface may be inclined downward in the gravity direction toward the opening portion 112.

On the other hand, the opening 112 is a hole into which the cap body 12 described later is fitted, and communicates the inside of the housing 111 with the outside of the liquid reservoir 11. In the present embodiment, the opening 112 is disposed such that a part of the outer wall of the opening 112 protrudes from the bottom surface of the reservoir 11.

Here, as shown in fig. 3A to 3D, the opening 112 of the present embodiment has a shape in which a pressing region 112a having a substantially elliptic cylindrical opening and an opening region 112b having a substantially circular cylindrical opening are connected to each other.

The pressing region 112a is a region for receiving the first region of the cap 12 when the case 100 is closed, and is a region for pressing a part of the cap 12 toward the center axis thereof. In the present embodiment, the first region of the cap body 12 has a columnar shape, and the opening of the pressing region 112a has a substantially elliptic columnar shape. Therefore, when the first region of the columnar cap body 12 is accommodated in the pressing region 112a, the first region of the cap body 12 is pressed toward the center axis of the cap body 12 by the outer wall of the pressing region 112 a. As a result, the through hole 120 of the first region of the cap body 12 is blocked, and the discharge of the fluid through the through hole 120 of the cap body 12 is suppressed.

The pressing region 112a may have a shape that at least a part of the through hole 120 of the first region of the cap body 12 is closed when the first region of the cap body 12 is stored, and may have, for example, the following openings: an opening having a constant opening cross-sectional area is formed from the outside of the reservoir 11 toward the open region 112 b. However, the pressing region 112a of the present embodiment has a tapered opening whose opening cross-sectional area decreases from the outside of the reservoir 11 to the open region 112b side, so that the cap body 12 can be easily fitted.

On the other hand, when the case 100 is in the open state, the second region of the cap 12 is housed in the pressing region 112 a. Therefore, the pressing region 112a of the present embodiment has an opening that is not blocked by the through hole 120 of the second region when the second region of the cap body 12 is housed.

The open region 112b of the opening 112 is a region for housing the first region of the cap body 12 when the case 100 is in the open state, and is a region in which the pressing force toward the central axis of the cap body 12 is smaller when the first region of the cap body 12 is housed than when the pressing region 112a is described above. In the present embodiment, the pressure toward the center axis of the cap body 12 is reduced by setting the open region 112b to a region having a larger opening cross-sectional area than the pressing region 112 a. The open region 112b of the present embodiment has an opening with a shape (columnar shape) similar to the outer shape of the first region of the cap body 12. When the first region of the cap body 12 is accommodated in the cylindrical open region 112b, the first region of the cap body 12 returns to the original cylindrical shape due to its flexibility. As a result, the through hole 120 is opened, and the fluid can pass through the through hole 120 of the cap body 12.

However, if a gap is formed between the open region 112b and the first region of the cap body 12, the fluid may be discharged to the outside of the housing portion 111 through the gap. Therefore, the open region 112b of the present embodiment has a cylindrical opening having a diameter smaller than that of the cylindrical first region of the cap body 12.

Here, the reservoir 11 having the storage portion 111 and the opening 112 may be made of a resin that is not corroded by the fluid stored in the storage portion 111. Examples of the material constituting the liquid reservoir 11 include: polyesters such as polyethylene terephthalate; a polycarbonate; acrylic resins such as polymethyl methacrylate; polyvinyl chloride; polyolefins such as polyethylene, polypropylene, and cycloolefin resins; a polyether; polystyrene; a silicone resin; and resin materials such as various elastomers. The reservoir 11 may be molded by injection molding or the like, for example.

Next, fig. 4A shows a perspective view of the upper surface side of the cap body 12 of the present embodiment, and fig. 4B shows a perspective view of the bottom surface side. Fig. 4C shows a front view of the cap body 12, and fig. 4D shows a plan view. Further, FIG. 4E is a cross-sectional view of the cap body 12 shown in FIG. 4D taken along line A-A, and FIG. 4F is a cross-sectional view of the cap body 12 shown in FIG. 4D taken along line B-B.

The cap body 12 of the present embodiment is a substantially columnar member, and has a through hole 120 substantially parallel to the center axis CA thereof. Further, the cap body 12 includes: a columnar first region 121 that is pressed by the outer wall of the opening 112 (pressing region 112a) when housed in the pressing region 112a of the opening 112 of the reservoir 11, and that closes the through-hole 120; and a columnar second region 122 having a smaller cross-sectional area in a direction perpendicular to the center axis of the cap body 12 than the first region 121. In the cap body 12, the bottom surface of the first region 121 and the top surface of the second region 122 are connected.

Here, the diameter of the columnar first region 121 can be appropriately set according to the opening width or the opening cross-sectional area of the opening 112 (the pressing region 112a and the open region 112b) of the reservoir 11. The shape of the through hole 120 in the first region 121 in the direction perpendicular to the central axis CA is not particularly limited as long as the first region 121 is closed without a gap when it is housed in the pressing region 112a of the reservoir 11, and may be, for example, a slit shape. In the present specification, the "slit shape" refers to a gap that is long in one direction in a cross section perpendicular to the center axis CA of the cap body 12 and is closed in a linear shape when pressed from both sides in the short axis direction. In the present embodiment, as shown in fig. 4A, the shape of the through hole 120 in the direction perpendicular to the center axis CA is a diamond shape having one diagonal line sufficiently long with respect to the other diagonal line.

Here, the opening width and the opening shape of the through hole 120 in the first region 121 in the direction perpendicular to the central axis CA may be appropriately selected according to the type of fluid and the desired flow rate of the fluid.

The height of the first region 121 is not particularly limited, and may be appropriately selected according to the shape of the opening 112 (the pressing region 112a and the open region 112b) of the reservoir 11. However, from the viewpoint of being able to discharge the fluid stored in the storage portion 111 without remaining in the storage portion 111, it is preferable that the end portion of the cap body 12 (the first region 121 side) does not protrude into the storage portion 111 when the first region 121 is stored in the open region 112b of the reservoir 11. That is, the height of the first region 121 is preferably set to be equal to or less than the height of the open region 112 b.

On the other hand, the diameter of the columnar second region 122 can be appropriately set in accordance with the opening width or the opening cross-sectional area of the pressing region 112a of the reservoir 11. The opening width and the opening shape of the through hole 120 in the second region 122 in the direction perpendicular to the central axis CA may be appropriately selected according to the type of fluid and the desired flow rate of the fluid, and may be the same as or different from the shape of the through hole 120 in the first region 121. In the present embodiment, the cross-sectional shape of the through hole 120 in the second region 122 in the direction perpendicular to the central axis CA is circular.

The height of the second region 122 may be appropriately selected, and for example, the height of the second region 122 may be set to a height at which a part of the second region 122 protrudes from the opening 112 of the reservoir 11 when the first region 121 is housed in the open region 112b of the reservoir 11. As will be described later, the case 100 of the present embodiment is used by inserting various sheets, devices, and the like into an end portion of the cap body 12 on the second region side (the side opposite to the housing portion 111 of the liquid reservoir 11). Therefore, the height of the second region 122 is not particularly limited as long as the end portion can be inserted into various pieces, devices, or the like.

Here, the cap body 12 may be made of a known elastic body as long as it is made of a material having flexibility. The elastomer resin includes a thermoplastic resin and a thermosetting resin, and the cap body 12 may be formed of any one of these resins. Examples of thermosetting elastomeric resins that can be used in the cap body 12 include: polyurethane-based resins, polysiloxane-based resins, and the like, and examples of the thermoplastic elastomer resin include: styrene resins, olefin resins, polyester resins, and the like. Specific examples of the olefin-based resin include polypropylene resins. The first region 121 and the second region 122 of the cap body 12 may be made of the same material or different materials. However, from the viewpoint of ease of production and the like, it is preferable to be made of the same material. The cap body 12 may be formed by injection molding or the like, for example.

The lid 13 of the case 100 may be any member that can prevent the fluid from leaking from the top surface side of the housing 111 when the fluid is housed in the housing 111 of the reservoir 11. The lid 13 may have a structure that can be attached to and detached from the reservoir 11, or may be a film or the like that is bonded to the reservoir 11. For example, the lid 13 may be configured to be bonded to the reservoir 11 with an adhesive (e.g., a hot-melt adhesive, a pressure-sensitive adhesive, or the like).

The thickness of the lid 13 may be appropriately selected as long as it is a film made of a material that is not corroded by the fluid. Examples of the material constituting the cover portion 13 include: polyesters such as polyethylene terephthalate; a polycarbonate; acrylic resins such as polymethyl methacrylate; polyvinyl chloride; polyolefins such as polyethylene, polypropylene, and cycloolefin resins; a polyether; polystyrene; a silicone resin; and resin materials such as various elastomers, or metals such as aluminum.

The lid 13 may have a partial opening, and the cap body made of the elastic body described above may be disposed in the opening. The shape of the opening of the lid 13 may be the same as the shape of the opening of the reservoir 11 described above, for example. The opening provided in the lid portion 13 and openable and closable by the cap can be used as an air vent or an introduction portion for filling a reagent into the reservoir.

2. Fluid treatment system

2-1. first embodiment

Fig. 5 shows an exploded perspective view of a fluid treatment system 200 according to a first embodiment including the cartridge 100 described above. The fluid processing system 200 of the present embodiment includes, in addition to the cartridge 100 described above, a flow path sheet 21 and a detachable spacer 22 disposed between the cartridge 100 and the flow path sheet 21. The fluid handling system 200 is used in a state where the end portion of the cap body 12 on the flow path sheet 21 side of the cartridge 100 (the end portion of the cap body 12 on the opposite side to the side facing the housing portion (hereinafter, also referred to as "second region side end portion")) is inserted into the flow path sheet 21. The flow path sheet 21 and the spacer in the fluid treatment system 200 will be described below, and then a fluid treatment method using the fluid treatment system 200 will be described.

The flow path sheet 21 of the present embodiment includes: a main body portion 21 a; and a film (not shown) attached to one surface of the main body 21a so as to cover the groove or the through hole provided in the main body. Fig. 6 shows a bottom view of the main body 21a of the flow channel sheet 21. The main body 21a includes: a first introduction port 211a and a second introduction port 211b for introducing a fluid into the flow path sheet 21, and a discharge port 212 for discharging the fluid from the flow path sheet 21. The first inlet 211a, the second inlet 211b, and the outlet 212 are through holes disposed in the body 21 a.

Further, the main body 21a further includes: a first groove 213a, which is a bottomed recess formed on the surface (hereinafter, also referred to as "back surface") of the main body 21a to be bonded to a film (not shown), and one end of which is connected to the first introduction port 211 a; a second groove 213b which is a bottomed recess formed on the rear surface side of the main body 21a and one end of which is connected to the second introduction port 211 b; and a third groove 213c, which is a bottomed recess formed on the back surface side of the body 21a, and has one end connected to the first groove 213a and the second groove 213b and the other end connected to the discharge port 212. In this channel sheet, the region surrounded by the thin film and the first groove 213a serves as a first channel, the region surrounded by the thin film and the second groove 213b serves as a second channel, and the region surrounded by the thin film and the third groove 213c serves as a third channel for the fluid.

In the channel sheet 21, for example, a first fluid (sample in the present embodiment) is introduced from the first inlet 211a, and a second fluid (reagent in the present embodiment) is introduced from the second inlet 211 b. Then, these fluids are allowed to flow into the third channel through the first channel and the second channel, and are allowed to react in the third channel. Thereafter, the reactant can be moved from the discharge port 212 toward the cartridge 100 via the cap body 12.

Examples of the material constituting the main body 21a include: polyesters such as polyethylene terephthalate; a polycarbonate; acrylic resins such as polymethyl methacrylate; polyvinyl chloride; polyolefins such as polyethylene, polypropylene, and cycloolefin resins; a polyether; polystyrene; a silicone resin; and resin materials such as various elastomers. The main body 21a having the above-described configurations may be molded by, for example, injection molding.

Here, the main body portion 21a may or may not have light-transmitting properties. When the fluid is viewed from the surface opposite to the back surface of the main body portion 21a, for example, a material capable of providing the main body portion 21a with translucency is selected.

On the other hand, the thin film (not shown) may be a flat film covering the main body 21 a. The thin film may be a film made of a material that is not corroded by the fluid introduced into the flow path sheet 21, and its thickness and the like may be appropriately selected. Examples of the material constituting the film include: polyesters such as polyethylene terephthalate; a polycarbonate; acrylic resins such as polymethyl methacrylate; polyvinyl chloride; polyolefins such as polyethylene, polypropylene, and cycloolefin resins; a polyether; polystyrene; a silicone resin; and resin materials such as various elastomers.

When the fluid is observed or analyzed from the thin film side in a state where the fluid is accommodated in the third channel, a material capable of imparting light transmittance to the thin film is selected as the material of the thin film. However, the film may not have translucency when the fluid is observed from the surface opposite to the back surface of the main body portion 21a, when the fluid is not observed, or the like.

The main body 21a and the film may be joined by a known method such as thermal welding or adhesion with an adhesive.

On the other hand, the spacer 22 in the fluid handling system is a member for keeping the first region 121 of the cap 12 of the cartridge 100 housed in the pressing region 112a of the opening 112 of the reservoir 11 with a sufficient space between the cartridge 100 and the flow path sheet 21.

The spacer 22 may be detachably disposed in the fluid treatment system 200, and in the present embodiment, it is a comb-shaped member that can be inserted from one direction between the cassette 100 and the flow path sheet 21, but the shape of the spacer 22 is not limited to this shape. In the present embodiment, the spacer 22 is disposed over substantially the entire region of the cartridge 100 facing the flow path sheet 21, but the spacer 22 may be disposed only in a part of the region of the cartridge 100 facing the flow path sheet 21.

The thickness of the spacer 22 may be selected as appropriate depending on, for example, the height of the second region of the cap body 12, as long as the first region of the cap body 12 housed in the pressing region 112a of the opening 112 of the reservoir 11 does not move toward the housing portion 111 of the reservoir 11 due to the weight of the reservoir 11 or an external impact. However, if the spacer 22 is too thick, the end of the cap 12 on the flow sheet 21 side may be separated from the inlet or the outlet (the first inlet 211a, the second inlet 211b, and the outlet 212) of the flow sheet 21. Therefore, the thickness is preferably set to an appropriate thickness according to the height of the cap body 12 and the like.

The material constituting the spacer 22 is not particularly limited as long as the gap between the cassette 100 and the flow path sheet 21 can be sufficiently maintained and the cassette 100 or the flow path sheet 21 is not damaged when the spacer 22 is pulled out or the like. Examples of the material of the spacer 22 include: polyesters such as polyethylene terephthalate; a polycarbonate; acrylic resins such as polymethyl methacrylate; polyvinyl chloride; polyolefins such as polyethylene, polypropylene, and cycloolefin resins; a polyether; polystyrene resin materials, and the like. The spacer 22 may be formed by injection molding or the like, for example.

The fluid treatment system 200 may further include a support portion or the like for supporting the reservoir 11 so as to prevent the reservoir 11 from being detached from the flow path sheet 21 or from being displaced from the flow path sheet 21 after the spacer 22 is detached from the fluid treatment system 200 as described below.

(fluid treatment method)

Next, a fluid treatment method using the fluid treatment system 200 will be described.

As shown in fig. 7A and 7B, the fluid processing system according to the present embodiment is prepared in a state where the cartridge 100, the flow path sheet 21, and the spacer 22 are combined. Further, fig. 7A is a sectional view taken along line a-a in fig. 5, and fig. 7B is a sectional view taken along line B-B in fig. 5.

In the cartridge 100 of the fluid handling system 200, the first region 121 of the cap 12 is housed in the pressing region 112a of the reservoir 11 in a state of being pressed from two directions (directions indicated by arrows in fig. 4A) along the minor axis direction of the diamond shape toward the center axis CA. On the other hand, the end portion of the cap body 12 on the flow path sheet 21 side (second region 122 side) is inserted into the inlet and the outlet of the flow path sheet 21.

At this time, the spacer 22 is disposed between the reservoir 11 and the flow path sheet 21 so as to prevent the cap 12 from being pushed toward the housing portion 111 of the reservoir 11 by the weight of the reservoir 11.

The housing portion 111 of the reservoir 11 of the cartridge 100 in the closed state is filled with a desired fluid, and the housing portion 111 is sealed by the lid portion 13. When the flow path sheet 21 described above is used, one of the three storage units 111 is filled with a sample, one is filled with a reagent, and the remaining one is empty for fluid collection. However, depending on the type of the flow path sheet 21, all the storage sections may be filled with fluid. In addition, various fluids (reagents or samples) may be filled in the reservoir 11 in advance.

The type of fluid stored in the case 100 (the storage portion 111 of the reservoir 11) is not particularly limited as long as the fluid can pass through the through hole 120 of the cap 12. The fluid may comprise a single component or may comprise multiple components. The fluid is not limited to a liquid, and may be a fluid in which a solid component is dispersed in a solvent, for example. Further, the solvent may be a fluid in which droplets (droplets) or the like that are not miscible with the solvent are dispersed.

In the fluid treatment system 200, when the fluid is discharged from the reservoir 11 to the channel sheet 21 side, the spacer 22 is detached as shown in fig. 8A and 8B. Then, as shown in fig. 9A and 9B, the first region of the cap body 12 is pressed toward the open region 112B side of the opening 112. Fig. 8A and 9A are cross-sectional views taken along line a-a in fig. 5, and fig. 8B and 9B are cross-sectional views taken along line B-B in fig. 5. In these drawings, the same components as those in fig. 7A and 7B are denoted by the same reference numerals. As a method of pressing the first region 121 of the cap body 12 toward the open region 112B as shown in fig. 9A and 9B from the state shown in fig. 8A and 8B, the reservoir 11 may be pressed downward in the gravity direction by the user or by the self-weight of the reservoir 11. The flow path sheet 21 and the reservoir 11 may be sandwiched by various means, and the first region 121 of the cap body 12 may be pressed toward the open region 112b of the opening 112. By this operation, the through holes 120 of the first and

second regions

121 and 122 of the cap body 12 are opened, and fluid can pass through the through holes 120 of the cap body 12.

In order to promote the flow of the fluid in the through hole 120 of the cap body 12, pressure may be applied to the inside of the housing portion 111 in which the fluid is housed, or the fluid may be sucked from a specific housing portion 111, as necessary. In addition, the fluid may be made to flow by utilizing a capillary phenomenon.

2-2. second embodiment

Fig. 10 shows an exploded perspective view of a fluid treatment system 300 according to a second embodiment including the cartridge 100 described above. The same components as those of the fluid treatment system 200 according to the first embodiment are denoted by the same reference numerals, and detailed description thereof is omitted.

The fluid processing system 300 of the present embodiment includes the flow path sheet 21 and the auxiliary member 324 in addition to the cartridge 100 described above. Further, in fig. 10, the cap body 12 of the case 100 and the auxiliary member 324 are integrated, but they are detachable and are generally formed separately. The fluid treatment system 300 may further include a spacer (not shown) similar to the spacer 22 of the first embodiment, but the auxiliary member 324 may also perform the same function as the spacer. The auxiliary member 324 will be described in detail below.

The auxiliary member 324 of the present embodiment is a member for supporting the second region 122 of the cap body 12 described above. Fig. 11A shows a perspective view of the auxiliary member 324, and fig. 11B shows a perspective view of the auxiliary member 324 when viewed from another angle. Fig. 11C is a plan view of the auxiliary member 324, and fig. 11D is a cross-sectional view taken along line a-a of fig. 11C. Fig. 12A is a perspective view showing a state before the cap body 12 is fitted into the auxiliary member 324, and fig. 12B is a perspective view showing a state after the cap body 12 is fitted into the auxiliary member 324. Fig. 12C is a plan view of the cap body 12 after the auxiliary member 324 is fitted therein, and fig. 12D is a cross-sectional view taken along line a-a in fig. 12C.

As shown in fig. 11A and 11B, the auxiliary member 324 of the present embodiment has a substantially cylindrical outer shape. The diameter of the auxiliary member 324 is not particularly limited as long as it does not interfere with other members. The auxiliary member 324 has a through hole 324c substantially parallel to a central axis (not shown) thereof, and as shown in fig. 12D, the second region 122 of the cap body 12 is embedded in the through hole 324 c. The diameter of the through hole 324c is substantially the same as the outer diameter of the second region 122 of the cap body 12.

As shown in fig. 11C and the like, the auxiliary member 324 includes two support portions 324a facing each other at the outer edge portion of the through hole 324C. The support portion 324a is a structure for supporting the side of the second region 122 of the cap body 12 from both sides. In the present embodiment, the support portions 324a are each configured in a columnar shape that surrounds approximately 1/4 times the outer peripheral surface of the second region 122 of the columnar cap body 12. The support portions 324a have a crescent shape in plan view. When each of the supporting portions 324a has such a shape, the shape obtained by combining the second region 122 of the cap body 12 and the two supporting portions 324a is substantially the same as the opening shape (elliptic cylindrical shape) of the pressing region 112a of the opening 112 of the liquid reservoir 11. Therefore, when the second region 122 of the cap body 12 is moved into the pressing region 112a of the opening 112 of the reservoir 11, the support portion 324a can also be moved into the pressing region 112 a. That is, the support portion 324a can move the cap body 12 while supporting the second region 122, and can suppress deformation of the second region 122 accompanying the movement.

However, the shape of the support portion 324a of the auxiliary member 324 may be appropriately selected according to the opening shape of the pressing region 112a of the opening 112 of the liquid reservoir 11, and is not limited to the above shape. In the present embodiment, the thickness from the distal end side to the proximal end side of the support portion 324a is constant, but the thickness may be changed according to the opening shape of the pressing region 112a of the reservoir 11.

In addition, the height of the support portion 324a may be appropriately selected according to the height of the second region 122 of the cap body 12. In the present embodiment, the height of the auxiliary member 324 (the height of the support portion 324a or the depth of the through hole 324 c) and the depth of the inlet (or the outlet) of the flow sheet 21 are set to be substantially equal to the height of the second region 122 of the cap body 12.

The auxiliary member 324 of the present embodiment has an annular recess 324b around the support portion 324 a. In the present embodiment, a part of the outer wall of the opening 112 of the reservoir 11 protrudes in an annular shape from the bottom surface side of the reservoir 11 toward the flow path sheet 21 side. Since the auxiliary member 324 has the annular recess 324b, a part of the outer wall of the opening 112 of the reservoir 11 can be fitted into the recess 324b as needed. As a result, when the cap body 12 and the auxiliary member 324 are moved toward the housing portion 111 of the reservoir 11, the through hole 120 of the cap body 12 is prevented from being closed, and thus, displacement or the like is less likely to occur.

The width and depth of the recess 324b can be appropriately selected according to the shape of the opening 112 of the reservoir 11. In the present embodiment, the width and depth of the recess 324b are set so that the outer wall (wall surface and bottom surface) of the opening 112 of the reservoir 11 comes into contact with the wall surface and bottom surface of the recess 324b when the second region 122 of the cap body 12 and the support portion 324a of the auxiliary member 324 are housed in the pressing region 112a of the opening 112 of the reservoir 11.

(fluid treatment method)

Next, a fluid treatment method using the fluid treatment system 300 will be described.

In the fluid processing system 300 of the present embodiment, first, as shown in fig. 13, the cassette 100, the flow path sheet 21, and the auxiliary member 324 are combined and provided. Fig. 14A shows a plan view of the fluid handling system 300 (for convenience, a state where the cover 13 is removed is shown), and fig. 14B shows a cross-sectional view taken along line a-a of fig. 14A.

Specifically, the first region 121 of the cap body 12 is housed in the pressing region 112a of the reservoir 11 in a state of being pressed from two directions (directions indicated by arrows in fig. 4A) along the minor axis direction of the rhombus toward the center axis CA.

After the second region 122 of the cap body 12 is fitted into the support portion 324a of the auxiliary member 324, the end portion of the cap body 12 on the flow path sheet 21 side is inserted into the inlet or the outlet of the flow path sheet 21.

At this time, a spacer (not shown) may be disposed between the reservoir 11 and the flow path sheet 21 as necessary to prevent the cap 12 from being pushed toward the housing portion 111 of the reservoir 11 by the weight of the reservoir 11. In addition, as in the first embodiment, the housing portion 111 of the reservoir 11 of the case 100 in the closed state is filled with a desired fluid, and the housing portion 111 is sealed by the lid portion 13.

As shown in fig. 15A and 15B, when fluid is discharged from the reservoir 11 to the flow path sheet 21 side, the cap body 12 and the auxiliary member 324 are pushed toward the reservoir 11 side. More specifically, the cap body 12 is press-fitted so that the first region 121 of the cap body 12 is housed in the open region 112b of the opening 112 of the reservoir 11. At this time, the auxiliary member 324 is also moved together with the cap body 12, and the second region 122 of the cap body 12 and the support portion 324a of the auxiliary member 324 are accommodated in the pressing region 112a of the opening 112 of the reservoir 11. At the same time, a part of the outer wall of the opening 112 of the reservoir 11 is accommodated in the recess 324b of the auxiliary member 324. Fig. 15B is a cross-sectional view taken along line a-a of the perspective view of fig. 15A.

Here, as shown in fig. 15B, as a method of pushing the cap body 12 and the auxiliary member 324 toward the reservoir 11, the weight of the reservoir 11 may be used, or the reservoir 11 may be pushed downward in the gravity direction by the user. The channel sheet 21 and the reservoir 11 may be sandwiched by various instruments, and the cap body 12 and the auxiliary member 324 may be pushed toward the reservoir 11. By this operation, the through holes 120 of the first and

second regions

2-3. third embodiment

Fig. 16 shows an exploded perspective view of a fluid treatment system 400 according to a third embodiment, which includes the cartridge 100 described above. The same components as those of the fluid treatment system 200 according to the first embodiment are denoted by the same reference numerals, and detailed description thereof is omitted.

The fluid processing system 400 of the present embodiment includes a flow path sheet 421 in addition to the cartridge 100 described above. The fluid treatment system 400 may further include a spacer (not shown) similar to the spacer 22 of the first embodiment, or may not include the spacer.

The flow channel sheet 421 of the present embodiment will be described in detail below. The flow channel sheet 421 of the present embodiment includes: a main body 421 a; and a film (not shown) attached to one surface of the main body 421a so as to cover the groove provided in the main body 421 a. Fig. 17 shows a bottom view of the main body 421a of the flow channel sheet 421. The main body 421a includes, similarly to the flow path sheet 21 of the first embodiment: a first introduction port 411a and a second introduction port 411b for introducing a fluid into the flow path sheet 421, and a discharge port 412 for discharging a fluid from the flow path sheet 421. The first inlet 411a, the second inlet 411b, and the discharge port 412 are through holes disposed in the main body 421 a.

The main body 421a further includes: a first groove 413a which is a bottomed recess formed on a surface (hereinafter, also referred to as "back surface") of the main body 421a to be bonded to a film (not shown), and one end of which is connected to the first introduction port 411 a; a second groove 413b which is a bottomed recess formed on the rear surface side of the main body 421a and one end of which is connected to the second introduction port 411 b; and a third groove 413c which is a bottomed recess formed on the rear surface side of the main body 421a, and has one end connected to the first groove 413a and the second groove 413b and the other end connected to the discharge port 412. In the channel sheet 421, the region surrounded by the thin film and the first groove 413a serves as a first channel, the region surrounded by the thin film and the second groove 413b serves as a second channel, and the region surrounded by the thin film and the third groove 413c serves as a third channel for the fluid. The method of using the flow channel sheet 421 is the same as the method of using the flow channel sheet 21 of the first embodiment.

Fig. 18A is a perspective view and fig. 18B is a plan view of a surface of the main body 421a opposite to the surface on which the first grooves 413a and the like are disposed. Fig. 18C is a cross-sectional view of line a-a in fig. 18B. As shown in fig. 18A, the flow path sheet 421 of the present embodiment includes two support portions 424a facing each other at the outer edge portions of the first introduction port 411a, the second introduction port 411b, and the discharge port 412.

The support portion 424a is a structure for supporting the side of the second region 122 of the cap body 12 from both sides. In the present embodiment, the support portions 424a are each configured in a columnar shape that surrounds approximately 1/4 times the outer peripheral surface of the second region 122 of the columnar cap body 12. The support portions 424a each have a crescent shape in plan view. When each of the supporting portions 424a has such a shape, the shape of the second region 122 of the cap body 12 together with the two supporting portions 424a is substantially the same as the opening shape (elliptic cylindrical shape) of the pressing region 112a of the opening 112 of the reservoir 11. Therefore, when the second region 122 of the cap body 12 is moved into the pressing region 112a of the opening 112 of the reservoir 11, the support portion 424a can also be moved into the pressing region 112 a. That is, the support portion 424a can move the cap body 12 while supporting the second region 122, and can suppress deformation of the second region 122 accompanying the movement.

However, the shape of the support portion 424a may be appropriately selected according to the opening shape of the pressing region 112a of the opening 112 of the liquid reservoir 11, and is not limited to the above shape. In the present embodiment, the thickness from the distal end side to the proximal end side of the support portion 424a is constant, but the thickness may be changed according to the opening shape of the pressing region 112a of the reservoir 11.

In addition, the height of the supporting portion 424a may be appropriately selected according to the height of the second region 122 of the cap body 12. In the present embodiment, the sum of the depth of the inlet or the outlet (the first inlet 411a, the second inlet 411b, and the outlet 412) and the height of the support portion 424a is set to be substantially equal to the height of the second region 122 of the cap body 12.

The flow channel sheet 421 of the present embodiment has an annular recess 424b around the support portion 424 a. In the present embodiment, a part of the outer wall of the opening 112 of the liquid reservoir 11 protrudes in an annular shape from the bottom surface side of the liquid reservoir 11 toward the flow path sheet 421 side. Since the flow channel sheet 421 has the annular recessed portion 424b, a part of the outer wall of the opening 112 of the liquid reservoir 11 can be fitted into the recessed portion 424b as necessary. As a result, when the cap body 12 and the flow path sheet 421 are moved toward the housing section 111 of the reservoir 11, the through hole 120 of the cap body 12 is prevented from being closed, and thus, displacement or the like is less likely to occur.

The width and depth of the recess 424b can be appropriately selected according to the shape of the opening 112 of the reservoir 11. In the present embodiment, the width and depth of the recess 424b are set so that the outer wall (wall surface and bottom surface) of the opening 112 of the reservoir 11 comes into contact with the wall surface and bottom surface of the recess 424b when the second region 122 of the cap body 12 and the supporting portion 424a of the flow path sheet 421 are housed in the pressing region 112a of the opening 112 of the reservoir 11.

(fluid treatment method)

Next, a fluid treatment method using the fluid treatment system 400 will be described.

In the fluid processing system 400 of the present embodiment, first, the cartridge 100 and the flow path sheet 421 are combined and installed. Specifically, the first region 121 of the cap body 12 is housed in the pressing region 112a of the reservoir 11 in a state of being pressed from two directions (directions indicated by arrows in fig. 4A) along the minor axis direction of the rhombus toward the center axis CA.

The side surface of the second region 122 of the cap body 12 is sandwiched by the support portion 424a of the flow path sheet 421, and the end portion of the cap body 12 on the second region 122 side is inserted into the first inlet 411a, the second inlet 411b, and the discharge port 412 of the flow path sheet 421.

At this time, a spacer (not shown) may be disposed between the reservoir 11 and the flow path sheet 421 as necessary to prevent the cap body 12 from being pushed toward the housing portion 111 of the reservoir 11 by the weight of the reservoir 11. In addition, as in the first embodiment, the housing portion 111 of the reservoir 11 of the case 100 in the closed state is filled with a desired fluid, and the housing portion 111 is sealed by the lid portion 13.

When the fluid is discharged from the reservoir 11 to the flow path sheet 421 side, the cap body 12 and the flow path sheet 421 are pushed toward the reservoir 11 side. More specifically, the cap body 12 is press-fitted so that the first region 121 is accommodated in the open region 112b of the opening 112. At this time, the flow path sheet 421 is also moved together with the cap body 12, and the second region 122 of the cap body 12 and the supporting portion 424a of the flow path sheet 421 are accommodated in the pressing region 112a of the opening 112 of the reservoir 11. At the same time, a part of the outer wall of the opening 112 of the reservoir 11 is accommodated in the recess 424b of the flow channel sheet 421.

As a method of pushing the cap 12 and the flow path sheet 421 toward the reservoir 11, the weight of the reservoir 11 may be used, or the reservoir 11 may be pushed downward in the direction of gravity by the user. The flow channel sheet 421 and the reservoir 11 may be sandwiched by various means. By this operation, the through holes 120 of the first and

second regions

(Effect)

According to the case of the above-described embodiment, the fluid stored in the storage portion can be discharged only by pushing the cap into the case after inserting one end of the cap (the second region-side end portion of the cap) into the introduction port of the desired flow path sheet or the like. Further, when a plurality of liquids are stored in the storage section in advance, they can be discharged simultaneously. Therefore, a desired fluid can be supplied to the sheet or the like without using a large-scale apparatus, and the cartridge is very useful from the viewpoint of cost and work efficiency. Further, when one end of the cap (the second region-side end of the cap) is inserted into the inlet of a desired flow path sheet or the like and then the cap is pushed into the case, the internal pressure in the housing portion of the accumulator increases. Therefore, the fluid stored in the storage portion is easily discharged by the increased internal pressure.

In addition, according to the fluid handling system of the first embodiment, various fluids can be supplied into the flow path sheet only by removing the spacer and pressing the cap into the reservoir. In the fluid handling system according to the second or third embodiment, the various fluids may be supplied into the flow path sheet only by pressing the cap body toward the case body.

In the fluid handling systems according to the second and third embodiments, the second region of the cap body can be moved toward the reservoir side while the second region of the cap body is protected by the support portion. Therefore, when the cap body is moved, the cap body can be suppressed from being broken or bent, and the fluid can be reliably moved to the flow path piece side. In these fluid handling systems, when the cap is moved, the auxiliary member or the concave portion of the channel sheet is fitted to a part of the outer wall of the opening of the reservoir, and therefore, a misalignment or the like is less likely to occur between them. Therefore, the fluid can be more reliably moved to the flow path sheet side.

In addition, in the second embodiment, there are also the following advantages: not only can an auxiliary member be used in place of the spacer, but also the spacer does not need to be detached.

In addition, in any of the fluid handling systems according to the embodiments, it is possible to perform an operation such as collection of a fluid into a reservoir, and it is possible to efficiently perform inspection or analysis of various fluids.

(modification example)

In the above description of the cartridge, the open region in the opening of the reservoir is disposed closer to the storage portion of the reservoir than the pressing region of the opening. However, in the opening of the reservoir, the pressing region may be disposed closer to the storage portion of the reservoir than the open region. In this case, the case can be set from the closed state to the open state by pulling the cap body from the storage portion side to the outside and moving the first storage portion stored in the pressing region into the open region.

In the above description of the cartridge, the case where the reservoir has the storage section independent from the opening section having the pressing area and the open area has been described, but the storage section may also serve as the open area. In this case, when the case is to be closed, the first region of the cap is accommodated in the pressing region. On the other hand, when the case is to be opened, the first region of the cap is pushed into the housing. Thereby, the pressing of the first region by the pressing region is released, and the fluid can pass through the through hole of the cap body.

In the above description of the cartridge, the opening of the pressing area of the reservoir is formed in an elliptical shape, but may be formed in a shape other than an ellipse.

In the above description of the cartridge, the case where the reservoir has a substantially rectangular parallelepiped shape is exemplified, but the shape of the reservoir may be any shape such as a cylindrical shape or a bag shape. The position of the opening is not limited to the bottom of the reservoir, and may be, for example, a side surface on the bottom side of the reservoir.

In the above description of the case, the cap body in which two concentric circular columns having different diameters are connected is described, but the shape of the cap body is not limited to this shape, and for example, a cylindrical structure having a uniform cross-sectional area from the first region to the second region (in this case, the opening diameter of the through-hole in the first region is smaller than the opening diameter of the through-hole in the second region) may be employed, or a conical structure having a continuously changing cross-sectional area may be employed. The cap may have a shape in which two prisms having different widths are connected, for example.

In the case, the cap may have a stopper or the like for preventing the first region of the cap from moving further from the open region of the opening of the reservoir to the storage portion side after the case is opened.

In addition, the case where the cartridge described above is combined with a specific flow path sheet has been described as an example, but the sheet combined with the cartridge is not particularly limited, and may be, for example, a micro flow path sheet. It may be used for supplying a fluid to various devices or sheets other than those described above.

The application claims priority based on japanese patent application No. 2018-014839, filed on 31.1.2018. The contents described in the specification and drawings are all incorporated in the specification of the present application.

Industrial applicability

The cartridge and the fluid processing system of the present invention can be applied to, for example, inspection and analysis of various fluids.

Description of the reference numerals

11 liquid reservoir

12 cap body

13 cover part

21. 421 flow path sheet

21a, 421a main body part

22 spacer

100 case

111 accommodating part

112 opening part

112a press area

112b open area

120 through hole

121 first region

122 second region

200. 300, 400 fluid treatment system

211a, 411a first introduction port

211b, 411b second introduction port

212. 412 discharge port

213a, 413a first groove part

213b, 413b second groove part

213c, 413c third groove

324 auxiliary parts

324a, 424a support

324b, 424b recess

324c through hole

Claims

1. A cartridge, comprising:

a reservoir including a housing portion for housing a fluid, and an opening portion disposed in a part of the housing portion and communicating the housing portion with an outside; and

a cap body made of a flexible elastic body, fitted into the opening of the reservoir, having a columnar shape, and having a through hole substantially parallel to a central axis thereof,

the box body is characterized in that the box body is provided with a plurality of through holes,

the opening of the reservoir includes: a pressing region for pressing a part of the cap body toward a central axis of the cap body; and an open region in which a pressing force toward a central axis of the cap body is smaller than the pressing region,

the cap body has a first region that is pressed toward a central axis of the cap body when the first region is located in the pressing region of the reservoir,

when the first region is located in the pressing region, the outer wall of the opening presses the first region toward the center axis of the cap body, and the through hole of the first region is closed, the fluid in the housing section is not discharged to the outside through the through hole,

when the first region moves into the open region and the through hole of the first region is opened, the fluid is discharged from the housing portion to the outside through the through hole.

2. A cartridge according to claim 1, wherein,

the first region is disposed at an end portion of the cap body on a side facing the receiving portion, and the through hole in the first region is slit-shaped.

3. A cartridge according to claim 1 or 2,

the open region of the reservoir is disposed closer to the housing portion than the pressing region, and has a larger opening cross-sectional area than the pressing region.

4. A cartridge according to any of claims 1-3,

a cross-sectional shape of the first region of the cap body in a direction perpendicular to the central axis is a circle,

the opening shape of the pressing region of the reservoir is an ellipse.

5. A cartridge according to any of claims 1-4,

the cap body has a second region having a smaller cross-sectional area of a cross-section perpendicular to a central axis of the cap body than the first region,

the first region is disposed closer to the storage portion side of the reservoir than the second region.

6. A fluid treatment system, comprising:

a cartridge according to any one of claims 1-5; and

a flow path sheet having an inlet port into which an end portion of the cap body opposite to the side facing the housing portion is inserted,

when the first region of the cap of the cartridge is moved from the pressing region side of the reservoir into the open region, fluid is discharged from the housing portion to the flow path piece side through the through hole of the cap.

7. The fluid treatment system defined in claim 6,

a spacer is also provided between the cassette body and the flow path sheet.

8. The fluid treatment system defined in claim 6,

there are also two support parts opposite to each other,

a side of the second region of the cap body is supported by the support portion,

when the first region of the cap body is moved from the pressing region side of the reservoir into the open region, the second region of the cap body and the support portion are received in the pressing region of the reservoir.

9. The fluid treatment system defined in claim 8,

and an auxiliary member disposed between the case and the flow path sheet,

the auxiliary member has the support portion.

10. The fluid treatment system defined in claim 9,

a part of an outer wall of the opening of the reservoir protrudes from a bottom surface side of the reservoir toward the flow path sheet,

the auxiliary member has a recess capable of being fitted to a part of an outer wall of the opening of the reservoir around the support portion.

11. The fluid treatment system defined in claim 8,

the flow path sheet has the support portion.

12. The fluid treatment system defined in claim 11,

the flow path sheet has a recess capable of being fitted to a part of an outer wall of the opening of the reservoir around the support portion.