CN111658624A - 树脂酸去氧肾上腺素颗粒 - Google Patents
树脂酸去氧肾上腺素颗粒 Download PDFInfo
- Publication number
- CN111658624A CN111658624A CN202010471359.2A CN202010471359A CN111658624A CN 111658624 A CN111658624 A CN 111658624A CN 202010471359 A CN202010471359 A CN 202010471359A CN 111658624 A CN111658624 A CN 111658624A
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- CN
- China
- Prior art keywords
- phenylephrine
- drug
- coating
- coated
- resin complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 title claims abstract description 226
- 229960001802 phenylephrine Drugs 0.000 title claims abstract description 222
- 239000002245 particle Substances 0.000 title claims abstract description 108
- 239000011347 resin Substances 0.000 claims abstract description 42
- 229920005989 resin Polymers 0.000 claims abstract description 42
- 229920001467 poly(styrenesulfonates) Polymers 0.000 claims abstract description 20
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 16
- 238000002360 preparation method Methods 0.000 claims abstract description 16
- 229940006186 sodium polystyrene sulfonate Drugs 0.000 claims abstract description 10
- 208000024891 symptom Diseases 0.000 claims abstract description 7
- 206010028735 Nasal congestion Diseases 0.000 claims abstract description 5
- 230000002459 sustained effect Effects 0.000 claims abstract description 5
- 208000026935 allergic disease Diseases 0.000 claims abstract description 4
- 206010022000 influenza Diseases 0.000 claims abstract description 4
- 208000037916 non-allergic rhinitis Diseases 0.000 claims abstract description 4
- 125000002091 cationic group Chemical group 0.000 claims abstract 10
- 229960002796 polystyrene sulfonate Drugs 0.000 claims abstract 10
- 239000011970 polystyrene sulfonate Substances 0.000 claims abstract 10
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical group CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 54
- 239000003814 drug Substances 0.000 claims description 45
- 238000000576 coating method Methods 0.000 claims description 39
- 239000011248 coating agent Substances 0.000 claims description 38
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims description 30
- 229960001680 ibuprofen Drugs 0.000 claims description 29
- 229960005489 paracetamol Drugs 0.000 claims description 29
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 21
- 229920002301 cellulose acetate Polymers 0.000 claims description 21
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 21
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 21
- 150000003839 salts Chemical class 0.000 claims description 14
- 230000037406 food intake Effects 0.000 claims description 10
- 229940124597 therapeutic agent Drugs 0.000 claims description 10
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims description 5
- 230000001754 anti-pyretic effect Effects 0.000 claims description 5
- -1 oxomazine Chemical compound 0.000 claims description 5
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 claims description 4
- CNIIGCLFLJGOGP-UHFFFAOYSA-N 2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole Chemical compound C=1C=CC2=CC=CC=C2C=1CC1=NCCN1 CNIIGCLFLJGOGP-UHFFFAOYSA-N 0.000 claims description 4
- 206010020751 Hypersensitivity Diseases 0.000 claims description 4
- MKXZASYAUGDDCJ-SZMVWBNQSA-N LSM-2525 Chemical compound C1CCC[C@H]2[C@@]3([H])N(C)CC[C@]21C1=CC(OC)=CC=C1C3 MKXZASYAUGDDCJ-SZMVWBNQSA-N 0.000 claims description 4
- 230000007815 allergy Effects 0.000 claims description 4
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- 229960003870 bromhexine Drugs 0.000 claims description 4
- OJGDCBLYJGHCIH-UHFFFAOYSA-N bromhexine Chemical compound C1CCCCC1N(C)CC1=CC(Br)=CC(Br)=C1N OJGDCBLYJGHCIH-UHFFFAOYSA-N 0.000 claims description 4
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims description 4
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 claims description 4
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- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 claims description 4
- LHGVFZTZFXWLCP-UHFFFAOYSA-N guaiacol Chemical compound COC1=CC=CC=C1O LHGVFZTZFXWLCP-UHFFFAOYSA-N 0.000 claims description 4
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims description 4
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 claims description 4
- 229960000991 ketoprofen Drugs 0.000 claims description 4
- WYWIFABBXFUGLM-UHFFFAOYSA-N oxymetazoline Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C)=C1CC1=NCCN1 WYWIFABBXFUGLM-UHFFFAOYSA-N 0.000 claims description 4
- 229940002612 prodrug Drugs 0.000 claims description 4
- 239000000651 prodrug Substances 0.000 claims description 4
- KWGRBVOPPLSCSI-WCBMZHEXSA-N pseudoephedrine Chemical compound CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WCBMZHEXSA-N 0.000 claims description 4
- 229960000351 terfenadine Drugs 0.000 claims description 4
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 claims description 3
- 229940035676 analgesics Drugs 0.000 claims description 3
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- 229960002009 naproxen Drugs 0.000 claims description 3
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 claims description 3
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 2
- AKNNEGZIBPJZJG-MSOLQXFVSA-N (-)-noscapine Chemical compound CN1CCC2=CC=3OCOC=3C(OC)=C2[C@@H]1[C@@H]1C2=CC=C(OC)C(OC)=C2C(=O)O1 AKNNEGZIBPJZJG-MSOLQXFVSA-N 0.000 claims description 2
- RJMIEHBSYVWVIN-LLVKDONJSA-N (2r)-2-[4-(3-oxo-1h-isoindol-2-yl)phenyl]propanoic acid Chemical compound C1=CC([C@H](C(O)=O)C)=CC=C1N1C(=O)C2=CC=CC=C2C1 RJMIEHBSYVWVIN-LLVKDONJSA-N 0.000 claims description 2
- RDJGLLICXDHJDY-NSHDSACASA-N (2s)-2-(3-phenoxyphenyl)propanoic acid Chemical compound OC(=O)[C@@H](C)C1=CC=CC(OC=2C=CC=CC=2)=C1 RDJGLLICXDHJDY-NSHDSACASA-N 0.000 claims description 2
- MDKGKXOCJGEUJW-VIFPVBQESA-N (2s)-2-[4-(thiophene-2-carbonyl)phenyl]propanoic acid Chemical compound C1=CC([C@@H](C(O)=O)C)=CC=C1C(=O)C1=CC=CS1 MDKGKXOCJGEUJW-VIFPVBQESA-N 0.000 claims description 2
- JALUUBQFLPUJMY-UHFFFAOYSA-N 2-(4-phenylphenyl)propanoic acid Chemical compound C1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 JALUUBQFLPUJMY-UHFFFAOYSA-N 0.000 claims description 2
- TYCOFFBAZNSQOJ-UHFFFAOYSA-N 2-[4-(3-fluorophenyl)phenyl]propanoic acid Chemical compound C1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC(F)=C1 TYCOFFBAZNSQOJ-UHFFFAOYSA-N 0.000 claims description 2
- XKSAJZSJKURQRX-UHFFFAOYSA-N 2-acetyloxy-5-(4-fluorophenyl)benzoic acid Chemical compound C1=C(C(O)=O)C(OC(=O)C)=CC=C1C1=CC=C(F)C=C1 XKSAJZSJKURQRX-UHFFFAOYSA-N 0.000 claims description 2
- SYCHUQUJURZQMO-UHFFFAOYSA-N 4-hydroxy-2-methyl-1,1-dioxo-n-(1,3-thiazol-2-yl)-1$l^{6},2-benzothiazine-3-carboxamide Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=NC=CS1 SYCHUQUJURZQMO-UHFFFAOYSA-N 0.000 claims description 2
- ZKLPARSLTMPFCP-UHFFFAOYSA-N Cetirizine Chemical compound C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-UHFFFAOYSA-N 0.000 claims description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 2
- OGDVEMNWJVYAJL-LEPYJNQMSA-N Ethyl morphine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OCC OGDVEMNWJVYAJL-LEPYJNQMSA-N 0.000 claims description 2
- OGDVEMNWJVYAJL-UHFFFAOYSA-N Ethylmorphine Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OCC OGDVEMNWJVYAJL-UHFFFAOYSA-N 0.000 claims description 2
- HSRJKNPTNIJEKV-UHFFFAOYSA-N Guaifenesin Chemical compound COC1=CC=CC=C1OCC(O)CO HSRJKNPTNIJEKV-UHFFFAOYSA-N 0.000 claims description 2
- PWWVAXIEGOYWEE-UHFFFAOYSA-N Isophenergan Chemical compound C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1 PWWVAXIEGOYWEE-UHFFFAOYSA-N 0.000 claims description 2
- ZCVMWBYGMWKGHF-UHFFFAOYSA-N Ketotifene Chemical compound C1CN(C)CCC1=C1C2=CC=CC=C2CC(=O)C2=C1C=CS2 ZCVMWBYGMWKGHF-UHFFFAOYSA-N 0.000 claims description 2
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims description 2
- SBDNJUWAMKYJOX-UHFFFAOYSA-N Meclofenamic Acid Chemical compound CC1=CC=C(Cl)C(NC=2C(=CC=CC=2)C(O)=O)=C1Cl SBDNJUWAMKYJOX-UHFFFAOYSA-N 0.000 claims description 2
- ZRVUJXDFFKFLMG-UHFFFAOYSA-N Meloxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=NC=C(C)S1 ZRVUJXDFFKFLMG-UHFFFAOYSA-N 0.000 claims description 2
- HOKDBMAJZXIPGC-UHFFFAOYSA-N Mequitazine Chemical compound C12=CC=CC=C2SC2=CC=CC=C2N1CC1C(CC2)CCN2C1 HOKDBMAJZXIPGC-UHFFFAOYSA-N 0.000 claims description 2
- UCHDWCPVSPXUMX-TZIWLTJVSA-N Montelukast Chemical compound CC(C)(O)C1=CC=CC=C1CC[C@H](C=1C=C(\C=C\C=2N=C3C=C(Cl)C=CC3=CC=2)C=CC=1)SCC1(CC(O)=O)CC1 UCHDWCPVSPXUMX-TZIWLTJVSA-N 0.000 claims description 2
- IJHNSHDBIRRJRN-UHFFFAOYSA-N N,N-dimethyl-3-phenyl-3-(2-pyridinyl)-1-propanamine Chemical compound C=1C=CC=NC=1C(CCN(C)C)C1=CC=CC=C1 IJHNSHDBIRRJRN-UHFFFAOYSA-N 0.000 claims description 2
- JAUOIFJMECXRGI-UHFFFAOYSA-N Neoclaritin Chemical compound C=1C(Cl)=CC=C2C=1CCC1=CC=CN=C1C2=C1CCNCC1 JAUOIFJMECXRGI-UHFFFAOYSA-N 0.000 claims description 2
- ISFHAYSTHMVOJR-UHFFFAOYSA-N Phenindamine Chemical compound C1N(C)CCC(C2=CC=CC=C22)=C1C2C1=CC=CC=C1 ISFHAYSTHMVOJR-UHFFFAOYSA-N 0.000 claims description 2
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Abstract
Description
时间(小时) | 溶出度% |
1 | 10%-30% |
2 | 30%-50% |
3 | 50%-70% |
4 | 60%-80% |
6 | 75%-95% |
8 | 85%-100% |
10 | 90%-100% |
12 | 90%-100% |
14 | 90%-100% |
组分 | 重量(kg)/批 | 重量%(w/w) |
游离型去氧肾上腺素<sup>1</sup> | 0.750 | 19.5 |
USP级聚苯乙烯磺酸钠(粒度为约74μm至约177μm) | 1.750 | 45.5 |
NF级乙酸纤维素 | 1.0095 | 26.25 |
NF级羟丙基纤维素 | 0.3365 | 8.75 |
NF级丙酮<sup>3</sup> | -- | -- |
USP级纯化水<sup>3</sup> | -- | -- |
总计 | 3.846 | 100.0 |
时间(小时) | 溶出度% |
1 | 20%-40% |
2 | 40%-60% |
3 | 50%-70% |
4 | 60%-80% |
6 | 75%-95% |
8 | 80%-100% |
10 | 90%-100% |
12 | 90%-100% |
14 | 90%-100% |
Claims (16)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/832,694 US20140271892A1 (en) | 2013-03-15 | 2013-03-15 | Phenylephrine resinate particles having good auc |
US13/832694 | 2013-03-15 | ||
CN201480015698.2A CN105263483A (zh) | 2013-03-15 | 2014-02-28 | 树脂酸去氧肾上腺素颗粒 |
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Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201480015698.2A Division CN105263483A (zh) | 2013-03-15 | 2014-02-28 | 树脂酸去氧肾上腺素颗粒 |
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Publication Number | Publication Date |
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CN111658624A true CN111658624A (zh) | 2020-09-15 |
Family
ID=50272778
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201480015698.2A Pending CN105263483A (zh) | 2013-03-15 | 2014-02-28 | 树脂酸去氧肾上腺素颗粒 |
CN202010471359.2A Pending CN111658624A (zh) | 2013-03-15 | 2014-02-28 | 树脂酸去氧肾上腺素颗粒 |
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Application Number | Title | Priority Date | Filing Date |
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CN201480015698.2A Pending CN105263483A (zh) | 2013-03-15 | 2014-02-28 | 树脂酸去氧肾上腺素颗粒 |
Country Status (14)
Country | Link |
---|---|
US (1) | US20140271892A1 (zh) |
EP (1) | EP2968223B1 (zh) |
JP (1) | JP6314206B2 (zh) |
CN (2) | CN105263483A (zh) |
AU (1) | AU2014238059B2 (zh) |
BR (1) | BR112015022975B1 (zh) |
CA (1) | CA2906357C (zh) |
HK (1) | HK1219885A1 (zh) |
IL (1) | IL241050B (zh) |
MX (1) | MX2015012340A (zh) |
PH (1) | PH12015502066A1 (zh) |
RU (1) | RU2675788C2 (zh) |
UA (1) | UA116372C2 (zh) |
WO (1) | WO2014149526A1 (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MA41152A (fr) * | 2014-12-12 | 2017-10-17 | Johnson & Johnson Consumer Inc | Procédé de fabrication de particules de résinate de phényléphrine ; particules de résinate de phényléphrine et utilisation des particules de résinate de phényléphrine dans des formulations pharmaceutiques |
CN109187832B (zh) * | 2018-09-30 | 2021-07-30 | 华润三九医药股份有限公司 | Lc-ms/ms测定去氧肾上腺素浓度的方法及样品的前处理方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1294519A (zh) * | 1999-02-18 | 2001-05-09 | 英法马有限公司 | 含有促进活性成分吸收活性的化合物的药物组合物 |
US20050266032A1 (en) * | 2003-12-17 | 2005-12-01 | Sovereign Pharmaceuticals, Ltd. | Dosage form containing multiple drugs |
US20090047343A1 (en) * | 2007-08-13 | 2009-02-19 | Hugh Huang | Method for stabilizing phenylephrine |
CN101534795A (zh) * | 2006-11-21 | 2009-09-16 | 麦克内尔-Ppc股份有限公司 | 改进释放的镇痛悬浮液 |
US20090324716A1 (en) * | 2008-06-26 | 2009-12-31 | Robert Shen | Coated Particles Containing Pharmaceutically Active Agents |
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2014
- 2014-02-28 WO PCT/US2014/019301 patent/WO2014149526A1/en active Application Filing
- 2014-02-28 JP JP2016500489A patent/JP6314206B2/ja active Active
- 2014-02-28 MX MX2015012340A patent/MX2015012340A/es unknown
- 2014-02-28 AU AU2014238059A patent/AU2014238059B2/en active Active
- 2014-02-28 RU RU2015144181A patent/RU2675788C2/ru active
- 2014-02-28 UA UAA201509684A patent/UA116372C2/uk unknown
- 2014-02-28 CN CN201480015698.2A patent/CN105263483A/zh active Pending
- 2014-02-28 CN CN202010471359.2A patent/CN111658624A/zh active Pending
- 2014-02-28 EP EP14709863.6A patent/EP2968223B1/en active Active
- 2014-02-28 CA CA2906357A patent/CA2906357C/en active Active
- 2014-02-28 BR BR112015022975-1A patent/BR112015022975B1/pt active IP Right Grant
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2015
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- 2015-09-11 PH PH12015502066A patent/PH12015502066A1/en unknown
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2016
- 2016-07-07 HK HK16107941.7A patent/HK1219885A1/zh unknown
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Also Published As
Publication number | Publication date |
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CN105263483A (zh) | 2016-01-20 |
JP2016512250A (ja) | 2016-04-25 |
IL241050B (en) | 2018-07-31 |
BR112015022975A8 (pt) | 2022-08-09 |
BR112015022975A2 (pt) | 2017-07-18 |
MX2015012340A (es) | 2016-06-29 |
WO2014149526A1 (en) | 2014-09-25 |
JP6314206B2 (ja) | 2018-04-18 |
UA116372C2 (uk) | 2018-03-12 |
CA2906357C (en) | 2021-03-16 |
NZ712317A (en) | 2020-09-25 |
HK1219885A1 (zh) | 2017-04-21 |
BR112015022975B1 (pt) | 2022-11-08 |
EP2968223B1 (en) | 2020-10-28 |
IL241050A0 (en) | 2015-11-30 |
AU2014238059B2 (en) | 2019-01-03 |
CA2906357A1 (en) | 2014-09-25 |
AU2014238059A1 (en) | 2015-09-17 |
PH12015502066A1 (en) | 2016-01-25 |
US20140271892A1 (en) | 2014-09-18 |
EP2968223A1 (en) | 2016-01-20 |
RU2015144181A (ru) | 2017-04-21 |
RU2675788C2 (ru) | 2018-12-25 |
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