CN111643571A - Traditional Chinese medicine pill for promoting reunion of fractured tendons and bones and preparation method thereof - Google Patents

Traditional Chinese medicine pill for promoting reunion of fractured tendons and bones and preparation method thereof Download PDF

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CN111643571A
CN111643571A CN202010679415.1A CN202010679415A CN111643571A CN 111643571 A CN111643571 A CN 111643571A CN 202010679415 A CN202010679415 A CN 202010679415A CN 111643571 A CN111643571 A CN 111643571A
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parts
bones
reunion
pill
fractured
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杨颖�
赵金荣
徐珺
王明明
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Peoples Hospital of SND
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Peoples Hospital of SND
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • A61K36/12Filicopsida or Pteridopsida
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/29Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A61K36/296Epimedium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704Polygonum, e.g. knotweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/716Clematis (leather flower)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • A61K36/746Morinda
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2068Compounds of unknown constitution, e.g. material from plants or animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2813Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

The invention discloses a Chinese medicinal pill for reunion of fractured tendons and bones and a preparation method thereof. The traditional Chinese medicine pill for promoting reunion of fractured bones comprises the following raw materials in parts by weight: 10-30 parts of prepared rhizome of rehmannia, 5-15 parts of dog tablet, 5-15 parts of morinda officinalis, 10-20 parts of angelica, 10-30 parts of fleece-flower root, 5-15 parts of epimedium, 5-15 parts of ligusticum wallichii, 5-15 parts of salvia miltiorrhiza, 5-15 parts of clematis root, 5-15 parts of bighead atractylodes rhizome, 10-30 parts of peach kernel and 3-8 parts of pilose antler. The Chinese medicinal pill for reunion of fractured tendons and bones provided by the invention has strict prescription and reasonable compatibility, has multiple effects of promoting blood circulation to remove blood stasis, relieving swelling and pain, reunion of fractured tendons and bones and the like, and can effectively and quickly cure diseases such as fracture and the like due to muscle and tendon injury by taking the pill as required. The Chinese medicinal pill for reunion of fractured tendons and bones has the advantages of simple preparation method, easy implementation, pure Chinese medicinal formula adopted as raw materials and no side effect.

Description

Traditional Chinese medicine pill for promoting reunion of fractured tendons and bones and preparation method thereof
Technical Field
The invention relates to a Chinese patent medicine for treating injured tendons and fractures, belongs to the field of Chinese patent medicine preparations, and particularly relates to a Chinese medicinal pill for reuniting tendons and bones and a preparation method thereof.
Background
The injured tendons and the fractures are the pain diseases which are frequently generated in people, particularly sports athletes, old people, children and crowds as well as traffic accidents, not only bring great pain to the injured and the injured, but also have very complicated and difficult treatment and are difficult to cure in a short period. For the patients with injured tendons and fractures, an orthopedist generally applies splint gypsum for fixation and then takes various pellet powder for promoting blood circulation, removing blood stasis, relieving swelling and pain and facilitating reunion of tendons and bones, the fracture reunion prescription after external fixation is few, the fracture traumas are different, the treatment modes are different, some are reset internal fixation, some are gypsum or splint external fixation, at present, unified standards do not exist, on the other hand, the medicines have various names and varieties, but the defects of single effect, slow curative effect, unsatisfactory effect and the like generally exist, the mood and the requirement of the patients in urgent treatment cannot be met, and the fracture reunion prescription suitable for healing after fracture reduction is urgently proposed, including long bones of limbs, short bones, flat bones, irregular fractures and the like, and can be used after the alignment and line braking treatment.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a traditional Chinese medicine pill for reunion of fractured tendons and bones and a preparation method thereof so as to solve the problems in the technical background.
In order to achieve the purpose, the invention is realized by the following technical scheme:
a traditional Chinese medicine pill for promoting reunion of fractured bones comprises the following raw materials in parts by weight: 10-30 parts of prepared rhizome of rehmannia, 5-15 parts of dog tablet, 5-15 parts of morinda officinalis, 10-20 parts of angelica, 10-30 parts of fleece-flower root, 5-15 parts of epimedium, 5-15 parts of ligusticum wallichii, 5-15 parts of salvia miltiorrhiza, 5-15 parts of clematis root, 5-15 parts of bighead atractylodes rhizome, 10-30 parts of peach kernel and 3-8 parts of pilose antler.
Further, the feed comprises the following raw materials in parts by weight: 15-25 parts of prepared rhizome of rehmannia, 8-12 parts of dog tablet, 8-12 parts of morinda officinalis, 12-18 parts of angelica, 15-25 parts of fleece-flower root, 8-12 parts of epimedium, 8-12 parts of ligusticum wallichii, 8-12 parts of salvia miltiorrhiza, 8-12 parts of clematis root, 8-12 parts of bighead atractylodes rhizome, 15-25 parts of peach kernel and 5-6 parts of pilose antler.
Further, the feed comprises the following raw materials in parts by weight: 20 parts of prepared rhizome of rehmannia, 10 parts of dog tablet, 10 parts of morinda officinalis, 15 parts of angelica, 20 parts of fleece-flower root, 10 parts of epimedium, 10 parts of ligusticum wallichii, 10 parts of salvia miltiorrhiza, 10 parts of clematis root, 10 parts of bighead atractylodes rhizome, 20 parts of peach kernel and 6 parts of pilose antler.
Further, yellow wine is also included.
Further, the morinda officinalis is morinda citrifolia.
Furthermore, the Chinese clematis root is used as the medicine.
Wherein the radix rehmanniae Preparata is radix rehmanniae Preparata, herba Violae, flos Lupuli, SHANYAN, and SHANQICAO. The prescription names are prepared from radix rehmanniae preparata, prepared rhizome of rehmannia and prepared rhizome of rehmannia with the following properties: sweet in flavor and slightly warm in nature. It enters liver and kidney meridians. The functional indications are as follows: has effects of replenishing blood and nourishing yin, and can be used for treating blood deficiency, sallow complexion, giddiness, cardiopalmus, insomnia, menoxenia, metrorrhagia, etc. Can be used for treating hectic fever due to deficiency of kidney-yin, hectic fever, night sweat, nocturnal emission, and diabetes, such as LIUWEIDIHUANG pill. Has effects of replenishing essence and nourishing marrow, and can be used for treating soreness of waist and knees, vertigo, tinnitus, and premature gray hair due to deficiency of liver and kidney essence and blood. The efficacy is as follows: prepared rehmannia root, radix rehmanniae Praeparata is sweet in taste, slightly warm and moist in nature, and has the effects of enriching blood and nourishing yin as well as replenishing essence and benefiting marrow.
The dog tablet is the Chinese medicine rhizoma Cibotii. Has effects of nourishing liver and kidney, strengthening waist and knee joint, and dispelling pathogenic wind and dampness. Is rhizome of rhizoma Cibotii of perennial herb of family Hyriopsis cumingii.
Hangzhou Baji is pungent in flavor and slightly warm in taste. Dominating pathogenic wind; the pain of yin failing to rise; strengthen the bones and muscles. Calming the five internal organs and tonifying the middle-jiao; strengthen mind and tonify qi. Slightly sweet and mild in flavor, tonifying deficiency, inducing yin to yang, reaching the bone, circulating meridians and strengthening muscle and skin striae. The epimedium herb can make the micro-yang and the internal yin combined, so as to make the body fluid rise and nourish the lung, and the tendon, the bone and the marrow.
Angelica, synonyms: drying the Chinese angelica. Nature and taste: sweet, pungent and warm. Meridian tropism: enter liver, heart and spleen meridians. The efficacy is as follows: tonify blood, regulate nodulation, activate blood, alleviate pain, moisten intestines to relieve constipation. The main treatment is as follows: menoxenia, amenorrhea, dysmenorrhea, abdominal pain due to deficiency and obstruction, traumatic injury, superficial infection, pyocutaneous disease, and constipation due to blood deficiency; the angelica mainly contains hydrocarbons, sucrose, vitamin B12, vitamin A and other substances, and has the effects of regulating the functional state of the uterus, resisting bacteria, VitE deficiency, reducing blood pressure, tranquilizing, easing pain, promoting urination and the like, namely native copper: and (4) medulla stachyi lead. Nature and taste: pungent, bitter and mild. Meridian tropism: enter liver and kidney meridians. The efficacy is as follows: disperse blood stasis and alleviate pain, join tendons and join bones. The main treatment is as follows: traumatic injury, swelling and pain due to blood stasis, traumatic fracture;
the radix Polygoni Multiflori is also called radix Polygoni Multiflori, which has red and white components and is used as the root tuber of radix Polygoni Multiflori. Nature and taste: bitter; sweet; astringency; mild in nature. Meridian tropism: liver; the kidney channel. The functional indications are as follows: nourishing blood and yin; loosening bowel to relieve constipation; checking malaria; dispelling wind; and (5) detoxifying. Dizziness due to blood deficiency; palpitations; insomnia; soreness and weakness of the waist and knees due to liver-kidney yin deficiency; the beard and hair are early white; tinnitus; spermatorrhea; constipation due to intestinal dryness; deficiency of chronic malaria; rubella with pruritus; sores and carbuncles; scrofula; hemorrhoids are treated.
Herba Epimedii is berberidaceae plant, and dried leaf of herba Epimedii, mainly produced in Shaanxi, Shanxi, Henan, Guangxi, etc. It is pungent, sweet and warm in flavor, and enters liver and kidney meridians. The main effects of epimedium are tonifying kidney yang, strengthening bones and muscles and dispelling wind-damp. It can be used for treating kidney essence deficiency, sexual impotence, infertility, frequent micturition, tendons and bones flaccidity, arthralgia due to wind-cold-dampness, and numbness of limbs.
Ligusticum wallichii, synonym: shanju, Xiangguo, Jingxiong, Taixiong, etc. Nature and taste: pungent, bitter and warm. Meridian tropism: enter liver, gallbladder, bladder and triple energizer meridians. The efficacy is as follows: promoting qi circulation, expelling pathogenic wind, removing dampness, promoting blood circulation, relieving pain, and relieving swelling. The main treatment is as follows: distending pain in chest and hypochondrium and stomach, common cold due to wind-cold, damp arthralgia, headache, postpartum anemic fainting, abdominal pain, blood stasis amenorrhea, carbuncle swelling, and swelling and pain due to traumatic injury; rhizoma Ligustici Chuanxiong mainly contains volatile oil, nitrogen-containing compound, lactone compound, neutral oil, etc., and has antibacterial, radioprotective, tranquilizing, heart tonifying, and myocardial ischemia and anoxia resisting effects.
Red sage root, nature and taste: bitter and slightly cold. Meridian tropism: it enters heart and liver meridians. The functional indications are as follows: dispel stasis and alleviate pain, activate blood and dredge meridians, clear heart fire and relieve restlessness.
The Chinese clematis, also called clematis root, is a commonly used wind-damp-dispelling medicine, pungent in nature and flavor and warm in nature, and enters bladder meridian. Has the functions of dispelling wind, eliminating dampness, dredging meridian and relieving pain. Clinically, it is commonly used for wind-damp arthralgia, numbness and spasm, disadvantaged joints, soreness and pain of waist and knees. It is often combined with yang-warming and blood-activating herbs such as Rou Gui and so on,
bighead atractylodes rhizome, named as Yu Zhu, is bitter, sweet and warm in nature and taste, and non-toxic, and enters spleen and stomach meridians. Has effects of invigorating qi, invigorating spleen, eliminating dampness, inducing diuresis, arresting sweating, and preventing miscarriage, and can be used for treating short breath, listlessness, sallow complexion, loose stool, diarrhea, edema, giddiness, cardiopalmus, cough with clear and thin phlegm, spontaneous perspiration due to qi deficiency, and threatened abortion.
Peach kernel, bitter, sweet and neutral in nature and taste. It enters heart, liver and large intestine meridians. The functional indications are as follows: promote blood circulation to remove blood stasis, moisten intestines to relieve constipation, relieve cough and relieve asthma. Can be used for treating amenorrhea, dysmenorrhea, abdominal mass, traumatic injury, intestinal dryness and constipation.
Lu Rong, sweet and warm, entering liver and kidney meridians, has the actions of tonifying kidney and yang, promoting the production of body fluid and tonifying blood, strengthening tendons and bones, and regulating Chong and ren meridians.
In the prescription, although the medicines have a plurality of flavors, the medicines are abundant but not blocked, mixed and disordered, so that the medicines are classified to some extent, the diseases belong to mild, severe, slow and urgent, and the symptoms and root causes are fixed, thereby effectively and quickly curing diseases such as tendon injury, fracture and the like. The compatibility principle of the medicines is as follows: after the early treatment of the fracture, the stagnation of qi is gradually eliminated along with the blood stasis, but the swelling and the stasis are not eliminated, the broken bones are not connected, or the broken bones are not firmly connected initially, so that the fracture is mainly treated by harmonizing nutrient and promoting tissue regeneration, nourishing the liver and kidney, strengthening muscles and bones, and promoting blood circulation and removing blood stasis, and relaxing tendons and activating collaterals to benefit joints. In the formula, angelica, ligusticum wallichii, fleece-flower root and bighead atractylodes rhizome, which are monarch drugs, have the effects of tonifying qi and nourishing blood; the pilose antler and the salvia miltiorrhiza are used for reuniting bones and tendons and are used as ministerial drugs; the peach kernel is used for promoting blood circulation and removing blood stasis; the combination of Lingxian and dog tablets can warm the channels, dredge the collaterals, dispel wind and remove dampness as guiding drugs. The combination of the medicines can tonify liver and kidney, strengthen tendons and bones, promote blood circulation to remove blood stasis and accelerate the early healing of fracture.
A preparation method of a traditional Chinese medicine pill for reuniting tendons and bones comprises the following steps: firstly, taking prepared rehmannia root, dog tablets, morinda officinalis, angelica, fleece-flower root, epimedium, ligusticum wallichii, salvia miltiorrhiza, clematis chinensis, bighead atractylodes rhizome, peach kernel and pilose antler according to the formula amount, and decocting the mixture into serous fluid or decocting the mixture into powder by yellow wine; then, 20-25 g of starch and 1-1.5 g of microcrystalline cellulose are respectively added into every 1000g of pulp decocted by yellow wine or powder decocted by decoction, and the mixture is uniformly mixed, and then 50-100 g of refined honey is added to prepare pills according to a conventional method; and finally, drying, coating with carbon, and polishing with talcum powder in sequence to obtain the carbon coating.
Further, the decocting is to put the prepared rhizome of rehmannia, the dog-shaped tablets, the morinda officinalis, the angelica, the fleece-flower root, the epimedium herb, the szechuan lovage rhizome, the salvia miltiorrhiza, the clematis root, the largehead atractylodes rhizome, the peach kernel and the pilose antler into a copper pot to be decocted by slow fire.
Further, the addition amount of the yellow wine is that the medicinal materials are not added, and the decocting time is 60-80 minutes.
Further, the slurry is viscous.
Compared with the prior art, the invention has the beneficial effects that:
1. the Chinese medicinal pill for reunion of fractured tendons and bones provided by the invention has strict prescription and reasonable compatibility, has multiple effects of promoting blood circulation to remove blood stasis, relieving swelling and pain, reunion of fractured tendons and bones and the like, and can effectively and quickly cure diseases such as fracture and the like due to muscle and tendon injury by taking the pill as required.
2. The Chinese medicinal pill for reunion of fractured tendons and bones has the advantages of simple preparation method, easy implementation, pure Chinese medicinal formula adopted as raw materials and no side effect.
Detailed Description
The embodiments of the present invention are described below with reference to specific embodiments, and other advantages and effects of the present invention will be easily understood by those skilled in the art from the disclosure of the present specification. The invention is capable of other and different embodiments and of being practiced or of being carried out in various ways, and its several details are capable of modification in various respects, all without departing from the spirit and scope of the present invention. It is to be noted that the features in the following embodiments and examples may be combined with each other without conflict.
Example 1
A traditional Chinese medicine pill for promoting reunion of fractured bones comprises the following raw materials in parts by weight: 10 parts of prepared rehmannia root, 15 parts of dog tablet, 5 parts of morinda root, 20 parts of angelica, 10 parts of fleece-flower root, 15 parts of epimedium, 15 parts of ligusticum wallichii, 5 parts of salvia miltiorrhiza, 5 parts of clematis root, 15 parts of bighead atractylodes rhizome, 10 parts of peach kernel and 8 parts of pilose antler.
The preparation method of the traditional Chinese medicine pill for reunion of fractured tendons and bones in the embodiment comprises the following steps: firstly, taking prepared rehmannia root, dog tablets, morinda citrifolia, Chinese angelica, fleece-flower root, epimedium herb, Szechuan lovage rhizome, red-rooted salvia root, clematis root, largehead atractylodes rhizome, peach seed and pilose antler according to the formula amount, and decocting the mixture into serous fluid or decocting the mixture into powder by yellow wine; then, 20-25 g of starch and 1-1.5 g of microcrystalline cellulose are respectively added into every 1000g of pulp decocted by yellow wine or powder decocted by decoction, and the mixture is uniformly mixed, and then 50-100 g of refined honey is added to prepare pills according to a conventional method; and finally, drying, coating with carbon, and polishing with talcum powder in sequence to obtain the carbon coating.
In the embodiment, the decoction is prepared by decocting radix rehmanniae preparata, dog tablets, morinda citrifolia, angelica sinensis, fleece-flower root, epimedium herb, ligusticum wallichii, salvia miltiorrhiza, clematis root, bighead atractylodes rhizome, peach kernel and pilose antler in a copper pot with slow fire.
In the embodiment, the addition amount of the yellow wine is that the medicinal materials are not used, and the decocting time is 60-80 minutes.
In this embodiment, the slurry is viscous.
Example 2
A traditional Chinese medicine pill for promoting reunion of fractured bones comprises the following raw materials in parts by weight: 30 parts of prepared rhizome of rehmannia, 5 parts of dog tablets, 15 parts of morinda citrifolia, 10 parts of angelica, 30 parts of fleece-flower root, 5 parts of epimedium, 5 parts of ligusticum wallichii, 15 parts of salvia miltiorrhiza, 15 parts of clematis root, 5 parts of bighead atractylodes rhizome, 30 parts of peach kernel and 3 parts of pilose antler. The preparation method of the traditional Chinese medicine pill for reunion of fractured tendons and bones in the embodiment is similar to that in the embodiment 1.
Example 3
A traditional Chinese medicine pill for promoting reunion of fractured bones comprises the following raw materials in parts by weight: 15 parts of prepared rehmannia root, 12 parts of dog tablet, 8 parts of morinda officinalis, 18 parts of angelica, 15 parts of fleece-flower root, 12 parts of epimedium, 12 parts of ligusticum wallichii, 12 parts of salvia miltiorrhiza, 8 parts of clematis root, 8 parts of bighead atractylodes rhizome, 25 parts of peach kernel and 5 parts of pilose antler. The preparation method of the traditional Chinese medicine pill for reunion of fractured tendons and bones in the embodiment is similar to that in the embodiment 1.
Example 4
A traditional Chinese medicine pill for promoting reunion of fractured bones comprises the following raw materials in parts by weight: 25 parts of prepared rhizome of rehmannia, 8 parts of dog tablets, 12 parts of morinda officinalis, 12 parts of angelica, 25 parts of fleece-flower root, 8 parts of epimedium, 8 parts of ligusticum wallichii, 12 parts of salvia miltiorrhiza, 12 parts of clematis root, 12 parts of bighead atractylodes rhizome, 15 parts of peach kernel and 6 parts of pilose antler. The preparation method of the traditional Chinese medicine pill for reunion of fractured tendons and bones in the embodiment is similar to that in the embodiment 1.
Example 5
A traditional Chinese medicine pill for promoting reunion of fractured bones comprises the following raw materials in parts by weight: 20 parts of prepared rehmannia root, 10 parts of dog tablet, 10 parts of morinda officinalis, 15 parts of angelica, 20 parts of fleece-flower root, 10 parts of epimedium, 10 parts of ligusticum wallichii, 10 parts of salvia miltiorrhiza, 10 parts of clematis root, 10 parts of bighead atractylodes rhizome, 20 parts of peach kernel and 6 parts of pilose antler. The preparation method of the traditional Chinese medicine pill for reunion of fractured tendons and bones in the embodiment is similar to that in the embodiment 1.
Application example
1. Clinical data
1.1 cases are selected according to the relevant diagnosis standard in the standard for curative effect of diagnosis of clinical symptoms of traditional Chinese medicine.
1.2 general data
There were 310 out-patient and in-patient cases, of which: 104 cases under 18 years old, 66 cases under 19 to 35 years old, 91 cases under 36 to 50 years old, 36 cases under 51 to 60 years old, and 13 cases over 60 years old.
2. Method of treatment
The broken ends of the fracture patients are oppositely jointed, externally fixed and orally taken, and the Chinese medicinal pills for reunion of fractured bones obtained in any one of the embodiments 1 to 5 are taken by 15 to 45 grams in three times a day by taking the Chinese medicinal pills for reunion of fractured bones obtained in the embodiment 5 as an example. The medicine is taken for 7 to 8 weeks according to the disease condition. And rechecking the mixture for 50 days, and counting the curative effect. The patients with clinical effect are followed up or the relapse condition is adjusted after 1 year and 2 years respectively.
3. Therapeutic results
3.1 therapeutic criteria
Is drawn up according to the clinical research guiding principle of new medicine (Chinese medicine) for treating fracture.
The effect is shown: the basic recovery function of the fracture part;
the method has the following advantages: the function of the fracture part is recovered;
and (4) invalidation: after treatment, the symptoms are not improved.
3.2 treatment outcome: the curative effect of the Chinese medicinal pill for promoting reunion of fractured bones is shown in table 1, and the effective or effective recurrence condition for treating the fractured bones is shown in table 2:
TABLE 1 statistics of fracture treatment effect of Chinese medicinal pill for reunion of fractured tendons and bones
Figure DEST_PATH_IMAGE002
TABLE 2 relapse
Figure DEST_PATH_IMAGE004
3.3 toxic side effects
The liver and kidney functions of the patients are not changed before and after the administration, which shows that the patients have no obvious toxic effect. After the medicine is taken by a patient, adverse symptoms such as diarrhea, nausea and the like do not exist, which indicates that the medicine has no side effect.
4. Clinical application effect
After the fracture patient is in contraposition connection with the broken end, the medicine can promote the local soft tissue to recover to normal, can promote the growth of callus at the fracture part, is favorable for the stable healing of the broken end, and has good clinical effect. The medicine has no obvious toxic effect and no side effect.
5. Typical cases
Zeng XX, male, age 70. Injure the right hand, the right hand cannot move. The right ulna fracture is diagnosed by the hospital X-ray picture. The treatment was observed at the outpatient clinic of the hospital. The manipulation is repeated, and the small bamboo plate is fixed externally. The Chinese medicinal pill for reunion of fractured tendons and bones is taken orally three times a day, 15 g each time. After seven weeks of administration, the radiographs were reviewed and the fracture had healed to near-clinical level with sufficient callus growth. The external fixation is released, and the injured limb moves automatically. After 1 year follow-up, the fracture of the right hand is not found abnormal.
Qin XX, female, 65 years old. The left hand was injured and the left ulna was fractured by X-ray. Reduction by manipulation and fixation of the small bamboo plate. The Chinese medicinal pill for reunion of fractured tendons and bones is taken orally three times a day, 15 g each time. After seven weeks of administration, the radiographs were reviewed and the fracture had healed to near-clinical level with sufficient callus growth. The external fixation is released, and the injured limb moves automatically. The affected limb functions normally after 1 year follow-up.
Ovarian XX, female, age 33. The right lower leg is traumatic. The right fibula fracture was diagnosed by X-ray. Hospitalization, manual reduction and external fixation of the bamboo splint. The Chinese medicine pill for reunion of fractured tendons and bones is taken orally three times a day, 10 g once. After six weeks of administration, the radiographs were reviewed and the fracture had healed to near-clinical level with sufficient callus growth. The external fixation is released, and the injured limb moves automatically. The affected limb functions normally after 1 year follow-up.
Huaxx, female, 17 years old. Injury to the right thigh, immobility of the injured limb at that time, pain, groanin. Hospital radiographs were diagnosed as 1/3 fractures below the right femur. Hospitalization in hospital, right thigh traction and external fixation of the small bamboo plate. The Chinese medicine pill for reunion of fractured tendons and bones is taken orally three times a day, 10 g once. The swelling subsided completely after taking the medicine for two weeks, and the fracture ends were basically stable. After taking the medicine for three weeks, the right thigh takes a second X-ray film, the fractured ends have fibrous connection, callus begins to appear, and the fracture part becomes stable day by day. After seven weeks of administration, the third X-ray photograph of the right thigh is close to clinical healing, the local soft tissue is recovered to be normal, the muscle is strong, enough callus exists at the fracture part, and the fracture broken end is quite stable. After eight weeks of administration, the external fixation is released. The injured limb can move automatically. After 2 years follow-up, all right thigh functions are normal.
Plum XX, male, 10 years old. The left leg is injured by falling. The left fibula fracture was diagnosed by X-ray. The observation and treatment in the outpatient clinic of the hospital, the manual reduction and the external fixation of the small bamboo boards. The Chinese medicine pill for reunion of fractured tendons and bones is taken orally three times a day, 5g each time. After 5 weeks of administration, the radiographs were reviewed and the fracture had healed to near-clinical level with sufficient callus growth. The external fixation is released, and the injured limb moves automatically. The affected limb is not abnormal after follow-up after 2 years.
The above-mentioned embodiments only express the specific embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention.

Claims (10)

1. The traditional Chinese medicine pill for promoting reunion of fractured bones is characterized by comprising the following raw materials in parts by weight: 10-30 parts of prepared rhizome of rehmannia, 5-15 parts of dog tablet, 5-15 parts of morinda officinalis, 10-20 parts of angelica, 10-30 parts of fleece-flower root, 5-15 parts of epimedium, 5-15 parts of ligusticum wallichii, 5-15 parts of salvia miltiorrhiza, 5-15 parts of clematis root, 5-15 parts of bighead atractylodes rhizome, 10-30 parts of peach kernel and 3-8 parts of pilose antler.
2. The traditional Chinese medicine pill for reunion of fractured tendons and bones as claimed in claim 1, which is characterized by comprising the following raw materials in parts by weight: 15-25 parts of prepared rhizome of rehmannia, 8-12 parts of dog tablet, 8-12 parts of morinda officinalis, 12-18 parts of angelica, 15-25 parts of fleece-flower root, 8-12 parts of epimedium, 8-12 parts of ligusticum wallichii, 8-12 parts of salvia miltiorrhiza, 8-12 parts of clematis root, 8-12 parts of bighead atractylodes rhizome, 15-25 parts of peach kernel and 5-6 parts of pilose antler.
3. The traditional Chinese medicine pill for reunion of fractured tendons and bones as claimed in claim 1, which is characterized by comprising the following raw materials in parts by weight: 20 parts of prepared rhizome of rehmannia, 10 parts of dog tablet, 10 parts of morinda officinalis, 15 parts of angelica, 20 parts of fleece-flower root, 10 parts of epimedium, 10 parts of ligusticum wallichii, 10 parts of salvia miltiorrhiza, 10 parts of clematis root, 10 parts of bighead atractylodes rhizome, 20 parts of peach kernel and 6 parts of pilose antler.
4. The traditional Chinese medicine pill for reunion of fractured tendons and bones as claimed in any one of claims 1 to 3, further comprising yellow wine.
5. The traditional Chinese medicine pill for promoting reunion of fractured bones of any one of claims 1 to 3, wherein the morinda officinalis is morinda citrifolia.
6. The pill as claimed in any one of claims 1 to 3, wherein the said Lingxian is used as root.
7. The preparation method of the traditional Chinese medicine pill for reunion of fractured tendons and bones as claimed in claim 4, which is characterized by comprising the following steps: firstly, taking prepared rehmannia root, dog tablets, morinda officinalis, angelica, fleece-flower root, epimedium, ligusticum wallichii, salvia miltiorrhiza, clematis chinensis, bighead atractylodes rhizome, peach kernel and pilose antler according to the formula amount, and decocting the mixture into serous fluid or decocting the mixture into powder by yellow wine; then, 20-25 g of starch and 1-1.5 g of microcrystalline cellulose are respectively added into every 1000g of pulp decocted by yellow wine or powder decocted by decoction, and the mixture is uniformly mixed, and then 50-100 g of refined honey is added to prepare pills according to a conventional method; and finally, drying, coating with carbon, and polishing with talcum powder in sequence to obtain the carbon coating.
8. The method for preparing a Chinese medicinal pill, as claimed in claim 7, wherein the decocting is carried out by decocting radix rehmanniae Preparata, Canine tablet, radix Morindae officinalis, radix Angelicae sinensis, Polygoni Multiflori radix, herba Epimedii, rhizoma Ligustici Chuanxiong, Saviae Miltiorrhizae radix, radix Clematidis, Atractylodis rhizoma, semen Persicae and cornu Cervi Pantotrichum in copper pot with slow fire.
9. The preparation method of the traditional Chinese medicine pill for reunion of fractured bones as claimed in claim 7, wherein the yellow wine is added in an amount of over the medicinal materials, and the decocting time is 60-80 minutes.
10. The method for preparing a Chinese medicinal pill, for promoting reunion of fractured bones, according to claim 7, wherein the slurry is in a viscous state.
CN202010679415.1A 2020-07-16 2020-07-16 Traditional Chinese medicine pill for promoting reunion of fractured tendons and bones and preparation method thereof Pending CN111643571A (en)

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Citations (3)

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Publication number Priority date Publication date Assignee Title
CN1432386A (en) * 2002-01-05 2003-07-30 覃业国 Bone setting pill
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Publication number Priority date Publication date Assignee Title
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CN108272943A (en) * 2018-03-08 2018-07-13 广东安诺药业股份有限公司 A kind of pharmaceutical composition and preparation method thereof for treating osteoporotic fracture
CN108295188A (en) * 2018-03-30 2018-07-20 重庆正刚中医骨科医院有限公司 Liver renal drug

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Application publication date: 20200911