CN111643385A - Mild anti-dandruff composition - Google Patents

Abstract

The invention belongs to the technical field of cosmetics, and particularly relates to a mild anti-dandruff composition. The composition comprises the following substances in percentage by mass: surfactant (b): 5 to 30 percent; sorbitol: 1 to 30 percent; 0.05-1% of undecylenic amide propyl trimethyl ammonium methyl sulfate. The composition disclosed by the invention uses sorbitol and undecylenic amide propyl trimethyl ammonium methyl sulfate matched with a surfactant, and has the effects of mild degreasing, moistening and moisturizing, mild bacteriostasis, dandruff removal and itching relieving on scalp. By utilizing the reasonable collocation of the compositions, the scalp environment can be improved, the scalp barrier can be repaired, the water-oil balance of the scalp can be promoted to be restored, and the dandruff problem can be solved by improving the scalp environment by utilizing the principle of synergistic interaction among the raw materials.

Description

Mild anti-dandruff composition

Technical Field

The invention belongs to the field of cosmetics, and particularly relates to a mild anti-dandruff composition.

Background

Shampoo and hair-care products having an anti-dandruff function have been of great market value, and in particular, there is a demand for products having a mild anti-dandruff effect while achieving a cleansing effect in the aspect of shampoo and hair-care.

At present, a plurality of shampoos capable of providing hair cleaning and anti-dandruff effects are available on the market, and most of the shampoos contain various anti-dandruff agents such as ZPT, OCT, chlorphenesin, ketoconazole and the like.

However, the existing anti-dandruff products on the market are many and cannot well meet the requirements of people. The performance of most anti-dandruff shampoos depends to some extent on the action of the anti-dandruff agent on malassezia, i.e., the amount of the bactericide left on the scalp during the shampooing process, to ensure the anti-dandruff effect, but dandruff is affected by multiple factors such as scalp flora imbalance, dryness, irritation, barrier dysfunction, etc., and the condition of improving dandruff only by sterilization only can be effective on dandruff caused by malassezia, and cannot meet the anti-dandruff requirement of people. On the other hand, the dandruff problem of the scalp can be thoroughly solved only by maintaining the microenvironment of the scalp and ensuring the health condition of the scalp while removing the dandruff. However, it is desirable to maintain the scalp in an optimum balance of mild cleansing and moisturizing while using effective bacteriostatic and bactericidal components in the shampoo.

Disclosure of Invention

In one aspect, the present application provides a composition comprising, in weight percent: 5-30% of surfactant, 1-30% of sorbitol and 0.05-1% of undecylenic amide propyl trimethyl ammonium methyl sulfate.

In some embodiments, the weight percentage of the surfactant is 8-27%; preferably, it is 10-25%.

In some embodiments, the surfactant is selected from at least one of an anionic surfactant, a zwitterionic surfactant, a nonionic surfactant.

In some embodiments, the anionic surfactant is selected from sulfate salts, sulfonates, fatty acyl amino acid salts, phosphates.

In some embodiments, the anionic surfactant is selected from at least one of sulfate ester salts, fatty acyl amino acid salts.

In some embodiments, the sulfate salt is selected from at least one of ammonium lauryl sulfate, sodium lauryl sulfate, potassium lauryl sulfate, TEA lauryl sulfate, ammonium laureth sulfate, sodium laureth sulfate, TEA laureth sulfate.

In some embodiments, the fatty acyl amino acid salt is selected from at least one of sodium lauroyl glutamate, disodium lauroyl glutamate, TEA lauroyl glutamate, sodium cocoamide glutamate, disodium cocoyl glutamate, TEA cocoyl glutamate, sodium lauroyl sarcosinate, sodium cocoyl sarcosinate, sodium myristoyl sarcosinate, sodium methyl cocoyl taurate, sodium cocoyl methyl taurate, sodium lauroyl oat amino acid, sodium lauroyl wheat amino acid.

In some embodiments, the anionic surfactant is selected from at least one of ammonium laureth sulfate, sodium laureth sulfate lauroyl sarcosinate, sodium lauroyl oat amino acid.

In some embodiments, the anionic surfactant is selected from sodium laureth sulfate and sodium lauroyl oat amino acid.

In some embodiments, the zwitterionic surfactant is selected from the group consisting of betaine-type and imidazoline-type surfactants.

In some embodiments, the zwitterionic surfactant is selected from at least one of lauryl betaine, coco betaine, myristyl betaine, lauryl hydroxysultaine, cocoyl hydroxysultaine, cocoamidopropyl betaine, myristamidopropyl betaine, sodium lauroamphoacetate, sodium cocoamphoacetate, sodium oleoamphoacetate, disodium lauroamphodiacetate, and disodium cocoamphodiacetate.

In some embodiments, the zwitterionic surfactant is selected from at least one of cocamidopropyl betaine, lauryl hydroxysultaine.

In some embodiments, the nonionic surfactant is selected from at least one of alkyl glycosides, alkyl ethanolamides.

In some embodiments, the nonionic surfactant is selected from at least one of decyl glucoside, lauryl glucoside, coco glucoside, myristyl glucoside, cocamide DEA, cocamide MEA, cocoyl methyl MEA.

In some embodiments, the nonionic surfactant is selected from cocamide MEA.

In some embodiments, the sorbitol is present in a weight percentage of 6-28%; more preferably 10-26%.

Sorbitol is generally used as a skin moisturizer in cosmetic compositions, and is often used for face skin and hand skin care. The application finds that sorbitol can be used in mild anti-dandruff shampoo and plays an excellent role in moisturizing scalp and hair. The application unexpectedly finds that the drying condition of the scalp is greatly improved by using the shampoo added with the sorbitol, and the scales of the scalp are obviously reduced after the shampoo is used for a plurality of times.

In some embodiments, the weight percent of the undecenamidopropyltrimethylammonium methylsulfate is 0.06 to 0.9%; more preferably 0.1 to 0.8%.

Undecylenamidopropyltrimethylammonium methylsulfate is commonly used in cosmetic compositions as an antimicrobial, antistatic, scalp conditioning agent. The application finds that undecene amide propyl trimethyl ammonium methyl sulfate is matched with sorbitol to be used in the shampoo, so that the shampoo has an excellent anti-dandruff effect, and the anti-dandruff effect is greatly improved on the anti-dandruff problem caused by various factors. The application surprisingly finds that when the undecylenamidopropyltrimethylammonium methyl sulfate is matched with the sorbitol to be used for shampoo, the scalp metabolism is slowly recovered to be normal, the scalp grease secretion is vigorous or the scalp is extremely dry, the scalp water and oil tend to be balanced, and the hair becomes softer and smoother.

In some embodiments, the combination further comprises one or more of a conditioning agent, a PH adjusting agent, a suspending agent, a thickening agent, a preservative.

In some embodiments, the conditioning agent is selected from one or more of polyquaternium-6, polyquaternium-10, polyquaternium-7, polyquaternium-22, polyquaternium-73, and guar hydroxypropyltrimonium chloride. Preferred is at least one of guar hydroxypropyltrimonium chloride and polyquaternium-7.

In some embodiments, the PH adjusting agent is selected from one or more of citric acid and sodium citrate, sodium hydroxide, potassium hydroxide and triethanolamine, preferably at least one of citric acid and sodium citrate.

In some embodiments, the weight percentage of the suspending agent is from 0.01% to 6%, preferably from 0.04% to 5%, more preferably from 0.05% to 2.5%.

In some embodiments, the suspending agent is selected from at least one of modified corn starch, di (hydrogenated tallow) phthalic acid amide, carbomer, xanthan gum, copolymers of the acrylic acid (esters) and mixtures thereof. Preferably modified corn starch.

In some embodiments, the weight percentage of the thickener is from 0.01% to 4%, preferably from 0.02% to 3.5%, more preferably from 0.03% to 3%.

In some embodiments, the thickener is selected from at least one of PEG-90M, PEG-14M, PEG-150 distearate, PEG-120 methyl glucose dioleate, hydroxypropyl methylcellulose, sodium chloride, ammonium chloride, sodium sulfate, zinc sulfate. Preferably at least one of PEG-14M, PEG-150 distearate and sodium chloride.

In some embodiments, the preservative is present in an amount of 0.01% to 4.5%, preferably 0.02% to 3%, more preferably 0.03% to 2% by weight.

In some embodiments, the preservative is selected from at least one of phenoxyethanol, sodium benzoate, ethylhexylglycerin, methylparaben, 1, 2-hexanediol. Preferably at least one of phenoxyethanol and sodium benzoate.

In one aspect, the application also provides the use of the composition in the preparation of a laundry article; preferably, the washing and caring product is selected from one or more of shampoo, hair conditioner, hair mask and hair care essential oil.

In one aspect, the present application also provides a laundry care product comprising the following components in weight percent, as shown in table 1:

TABLE 1

On one hand, the application also provides a preparation method of the washing and caring product, which is characterized by comprising the following steps:

1) adding PEG-14M and water into a reaction kettle, homogenizing, stirring uniformly, adding cocamidopropyl betaine and lauryl hydroxy sulfobetaine, and heating to 75-80 ℃;

2) adding sodium laureth sulfate and sodium lauroyl avenantenin, stirring, and dissolving;

3) adding water-dispersed guar hydroxypropyl trimethyl ammonium chloride into the solution prepared in the step 2);

4) adding Cocoamide MEA, modified corn starch, sodium benzoate, and PEG-150 distearate, stirring, maintaining the temperature for 20-30min, cooling to 45 deg.C, adding phenoxyethanol, undecylenamidopropyl trimethylammonium methyl sulfate, sodium chloride, and sorbitol, and stirring;

5) adding polyquaternium-7 and essence, and regulating pH to 5.0-6.5 with citric acid;

6) cooling to 32-40 deg.C, and filtering.

Detailed Description

The technical solutions of the present application are further illustrated by the following specific examples, which do not represent a limitation to the scope of the present application. Insubstantial modifications and adaptations of the concepts taught herein by others are intended to be covered by the present disclosure.

"comprising" or "including" is intended to mean that the compositions (e.g., media) and methods include the recited elements, but not excluding others. When used in defining compositions and methods, "consisting essentially of … …" is meant to exclude other elements having any significance to the combination of the stated objects. Thus, a composition consisting essentially of the elements defined herein does not exclude other materials or steps that do not materially affect the basic and novel characteristics of the claimed application. "consisting of … …" refers to trace elements and substantial process steps excluding other components. Embodiments defined by each of these transition terms are within the scope of the present application.

Examples 1 to 3

The shampoo components of examples 1-3 were prepared according to the formulation of table 2.

TABLE 2

The shampoos of examples 1-3 were prepared as follows:

adding PEG-14M and cold water into a reaction kettle, homogenizing, uniformly stirring, and then adding cocamidopropyl betaine and lauryl hydroxy sulfobetaine. Heating to 75-80 deg.C;

adding sodium laureth sulfate and sodium lauroyl avenantamino acid, and stirring until the sodium laureth sulfate and the sodium lauroyl avenantamino acid are dissolved;

adding the solution of guar gum hydroxypropyl trimethyl ammonium chloride dispersed by water;

adding the cocamide MEA, the modified corn starch, the sodium benzoate and the PEG-150 distearate, stirring uniformly, keeping the temperature for 20-30min, cooling to 45 ℃, adding the phenoxyethanol, the undecylenic acid amidopropyl trimethyl ammonium methyl sulfate, the sodium chloride and the sorbitol, and stirring uniformly;

adding polyquaternium-7 and essence, and adjusting the pH value to 5.0-6.5 by using citric acid;

cooling to 37 deg.C, filtering and discharging.

Seventhly, after the inspection is qualified, subpackaging, packaging, inspecting again, and warehousing finished products.

Comparative examples 1 to 7

The components of the shampoos of comparative examples 1-7 were prepared according to the formulation of table 3.

TABLE 3

The preparation method is the same as in examples 1-3.

Comparative example 1 differs from example 1 in that comparative example 1 does not contain sorbitol.

Comparative example 2 differs from example 1 in that comparative example 2 does not contain undecenylamidopropyltrimethylammonium methylsulfate.

Comparative example 3 differs from example 1 in that comparative example 3 contains a surfactant outside the recommended range.

Comparative example 4 differs from example 1 in that comparative example 4 contains a surfactant outside the recommended range.

Comparative example 5 differs from example 1 in that comparative example 5 does not contain an amphoteric surfactant.

Comparative example 6 differs from example 1 in that comparative example 6 does not contain a nonionic surfactant.

Comparative example 7 differs from example 1 in that comparative example 7 does not contain an anionic surfactant

Correlation test

Human body patch test

1. The test substance: the shampoo of examples 1-3 and the shampoo of comparative examples 1-7 of the invention;

2. subject: a total of 60 men, 25 women, age 20-55 years, meeting the volunteer enrollment criteria of the subject;

3. the test method comprises the following steps: placing the tested object in a proper spot sticking device by adopting a closed test method, sticking the tested object on the arm curve side of the tested object by using a hypoallergenic adhesive tape, and lightly pressing the tested object by using a palm to uniformly stick the tested object on the skin for 24 hours; the blank control group was subject without product;

4. and (4) observing results: the test devices were removed after 24 hours, skin reactions were observed after 0.5h, 24h, 48h, respectively, and the results were recorded. The grade of adverse reaction of skin is shown in Table 4, and the test results are shown in Table 5

TABLE 4 skin reaction grading Standard for skin Enclosed Patch test

TABLE 5 body skin Patch test results

The results showed that of 60 subjects, 0 of example 1, example 2, example 3, comparative example 1, comparative example 2, comparative example 5, comparative example 6, comparative example 7 exhibited adverse cutaneous reactions, 2 of comparative example 3 exhibited adverse cutaneous reactions, and 1 of each of comparative example 4, comparative example 5, comparative example 6 exhibited adverse cutaneous reactions.

Examples 1,2 and 3 compared with comparative examples 3 and 4, examples 1,2 and 3 have no adverse reaction, example 3 has 2 first-order adverse reactions, and example 4 has 1 first-order adverse reaction, which shows that the shampoo formula of the surfactant with an excessive dosage can cause skin irritation.

Compared with comparative examples 5 and 6, examples 1,2 and 3 have no adverse reaction, and comparative examples 5 and 6 respectively have 1 first-order adverse reaction, which shows that the addition of the zwitterionic surfactant and the nonionic surfactant can reduce irritation.

The shampoo disclosed by the embodiment 1-3 is safe and non-irritant, and the mild anti-dandruff shampoo disclosed by the invention is safe and mild to skin.

Performance testing

Experiment of corrosion prevention challenge

Preservation challenge test (test according to the method of European pharmacopoeia (EP7.0) and test results are shown in Table 6 below)

TABLE 6

As can be seen from table 6, the shampoos of examples 1-3 of the present invention passed the anti-corrosion challenge test and simulated microbial contamination during the production and use of cosmetics, thereby avoiding the possible damage to consumers during the use of the product, and the results indicate the safety of mild anti-dandruff shampoos.

Human sensory evaluation

220 volunteers were recruited, and after grouping, were randomly grouped, each group consisting of 20 volunteers continuously used each group of shampoo for 8 weeks, and the testers scored according to the use feeling. The scoring criteria used a 7 point scale, with 1 point being the worst, 7 points being the best, with higher points being better. The final results are shown in Table 7:

TABLE 7

As can be seen from table 7, the shampoo compositions of the present invention provide mild cleansing of hair scalp after application, and provide mild dandruff control and improved itch benefits, with greater advantage than commercially available dandruff control shampoo a. Is generally favored by testers.

Comparative example 1 differs from example 1 in that comparative example 1 does not contain sorbitol, and shampoo shows poor performance in terms of itching and dandruff removal of the scalp of a test person after use.

Comparative example 2 differs from example 1 in that comparative example 2 did not contain undecylenamidopropyltrimethylammonium methylsulfate and was less satisfactory for scalp itching, anti-dandruff and overall for the test subjects after shampoo application.

Comparative examples 3 and 4 are different from example 1 in that comparative examples 3 and 4 contain surfactants out of the recommended range and perform well in terms of foam after shampoo application, but have poor scalp itching, dandruff removal and overall satisfaction with the testers.

Comparative example 5 differs from example 1 in that comparative example 5 does not contain an amphoteric surfactant, and comparative example 6 differs from example 1 in that comparative example 6 does not contain a nonionic surfactant, and after shampoo application, the overall performance in terms of foam is slightly poor, the cleanliness is slightly reduced, but the anti-itch, anti-dandruff, and overall satisfaction are poor.

Comparative example 7 differs from example 1 in that comparative example 7 does not contain an anionic surfactant and scores lower on foam.

The results show that the mild anti-dandruff shampoo disclosed by the invention is good in use feel, has the effects of mild cleaning, itching resistance, dandruff improvement and the like, and has a synergistic effect among the components in the formula, so that the overall use effect is good.

In view of the many possible embodiments to which the principles of the disclosed invention may be applied, it should be recognized that the illustrated embodiments are only preferred examples of the application and should not be taken as limiting the scope of the application. Rather, the scope of the application is defined by the appended claims. We therefore claim as our invention all that comes within the scope and spirit of these claims.

Claims (10)

1. The composition is characterized by comprising the following components in percentage by weight:

5-30% of surfactant, 1-30% of sorbitol and 0.05-1% of undecylenic amide propyl trimethyl ammonium methyl sulfate.

2. The composition of claim 1, wherein the weight percent of the surfactant is from 8% to 27%; preferably, it is 10-25%;

preferably, the surfactant is selected from at least one of anionic surfactant, zwitterionic surfactant and nonionic surfactant;

preferably, the anionic surfactant is selected from the group consisting of sulfate ester salts, sulfonates, fatty acyl amino acid salts, phosphates;

preferably, the anionic surfactant is selected from at least one of sulfate ester salt and fatty acyl amino acid salt;

preferably, the sulfate salt is at least one selected from ammonium lauryl sulfate, sodium lauryl sulfate, potassium lauryl sulfate, TEA lauryl sulfate, ammonium laureth sulfate, sodium laureth sulfate and TEA laureth sulfate;

preferably, the fatty acyl amino acid salt is selected from at least one of sodium lauroyl glutamate, disodium lauroyl glutamate, TEA lauroyl glutamate, sodium cocoamide glutamate, disodium cocoyl glutamate, TEA cocoyl glutamate, sodium lauroyl sarcosinate, sodium cocoyl sarcosinate, sodium myristoyl sarcosinate, sodium methyl cocoyl taurate, sodium cocoyl methyl taurate, sodium lauroyl oat amino acid, and sodium lauroyl wheat amino acid;

preferably, the anionic surfactant is selected from at least one of ammonium laureth sulfate, sodium laureth sulfate lauroyl sarcosinate and sodium lauroyl oat amino acid;

preferably, the anionic surfactant is selected from sodium laureth sulfate and sodium lauroyl oat amino acid.

3. The composition of claim 2, wherein said zwitterionic surfactant is selected from the group consisting of betaine-type and imidazoline-type surfactants;

preferably, the zwitterionic surfactant is selected from at least one of lauryl betaine, coco betaine, myristyl betaine, lauryl hydroxysultaine, cocoyl hydroxysultaine, cocamidopropyl betaine, myristamidopropyl betaine, sodium lauroamphoacetate, sodium cocoamphoacetate, sodium oleoamphoacetate, disodium lauroamphodiacetate, and disodium cocoamphodiacetate;

preferably, the zwitterionic surfactant is selected from at least one of cocamidopropyl betaine, lauryl hydroxysultaine.

4. The composition of claim 2, wherein the nonionic surfactant is selected from at least one of alkyl glycoside, alkyl ethanolamide;

preferably, the nonionic surfactant is selected from at least one of decyl glucoside, lauryl glucoside, coco glucoside, myristyl glucoside, cocamide DEA, cocamide MEA, cocoyl methyl MEA;

preferably, the nonionic surfactant is selected from cocamide MEA.

5. The composition of claim 1, wherein the sorbitol is present in a weight percent of 6 to 28%; more preferably 10-26%.

6. The composition of claim 1, wherein the weight percent of undecenamidopropyltrimethylammonium methylsulfate is 0.06-0.9%; more preferably 0.1 to 0.8%.

7. The composition of claim 1, wherein the combination further comprises one or more of a conditioning agent, a PH adjusting agent, a suspending agent, a thickening agent, a preservative.

8. Use of a composition according to claim 1 for the preparation of a cleaning product; preferably, the washing and caring product is selected from one or more of shampoo, hair conditioner, hair mask and hair care essential oil.

9. The washing and protecting product is characterized by comprising the following components in percentage by weight:

10. a process for the preparation of a laundry product according to claim 9, comprising the steps of:

1) adding PEG-14M and water into a reaction kettle, homogenizing, stirring uniformly, adding cocamidopropyl betaine and lauryl hydroxy sulfobetaine, and heating to 75-80 ℃;

2) adding sodium laureth sulfate and sodium lauroyl avenantenin, stirring, and dissolving;

3) adding water-dispersed guar hydroxypropyl trimethyl ammonium chloride into the solution prepared in the step 2);

4) adding Cocoamide MEA, modified corn starch, sodium benzoate, and PEG-150 distearate, stirring, maintaining the temperature for 20-30min, cooling to 45 deg.C, adding phenoxyethanol, undecylenamidopropyl trimethylammonium methyl sulfate, sodium chloride, and sorbitol, and stirring;

5) adding polyquaternium-7 and essence, and regulating pH to 5.0-6.5 with citric acid;

6) cooling to 32-40 deg.C, and filtering.