CN111572833B - Filling, plugging and capping device and method for liquid medicine packaging bottle with protrusions - Google Patents
Filling, plugging and capping device and method for liquid medicine packaging bottle with protrusions Download PDFInfo
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- CN111572833B CN111572833B CN201910837741.8A CN201910837741A CN111572833B CN 111572833 B CN111572833 B CN 111572833B CN 201910837741 A CN201910837741 A CN 201910837741A CN 111572833 B CN111572833 B CN 111572833B
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- bottle
- plugging
- filling
- pressing
- liquid
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- 239000007788 liquid Substances 0.000 title claims abstract description 106
- 239000003814 drug Substances 0.000 title claims abstract description 49
- 238000004806 packaging method and process Methods 0.000 title claims abstract description 28
- 238000000034 method Methods 0.000 title claims abstract description 17
- 230000007246 mechanism Effects 0.000 claims abstract description 101
- 229930182555 Penicillin Natural products 0.000 claims abstract description 71
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims abstract description 71
- 229940049954 penicillin Drugs 0.000 claims abstract description 71
- 238000003825 pressing Methods 0.000 claims abstract description 64
- 239000011247 coating layer Substances 0.000 claims abstract description 50
- 238000003860 storage Methods 0.000 claims abstract description 18
- 238000002347 injection Methods 0.000 claims abstract description 12
- 239000007924 injection Substances 0.000 claims abstract description 12
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229910052782 aluminium Inorganic materials 0.000 claims abstract description 11
- 238000005096 rolling process Methods 0.000 claims abstract description 4
- 239000010410 layer Substances 0.000 claims description 42
- 238000007664 blowing Methods 0.000 claims description 25
- 239000002033 PVDF binder Substances 0.000 claims description 12
- 229920002981 polyvinylidene fluoride Polymers 0.000 claims description 12
- NWGZZGNICQFUHV-OAHLLOKOSA-N C[C@@H](OP(=O)(N1CC1)N1CC1)C1=CC(OC2=CC(=CC=C2)C(=O)N(C)C)=C(C=C1)[N+]([O-])=O Chemical compound C[C@@H](OP(=O)(N1CC1)N1CC1)C1=CC(OC2=CC(=CC=C2)C(=O)N(C)C)=C(C=C1)[N+]([O-])=O NWGZZGNICQFUHV-OAHLLOKOSA-N 0.000 claims description 6
- 239000012530 fluid Substances 0.000 claims description 6
- 229910001220 stainless steel Inorganic materials 0.000 claims description 6
- 239000010935 stainless steel Substances 0.000 claims description 6
- 230000006835 compression Effects 0.000 claims description 5
- 238000007906 compression Methods 0.000 claims description 5
- 230000003139 buffering effect Effects 0.000 claims description 2
- 239000011248 coating agent Substances 0.000 claims description 2
- 238000000576 coating method Methods 0.000 claims description 2
- 238000001802 infusion Methods 0.000 claims 1
- 230000037452 priming Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 4
- 210000004907 gland Anatomy 0.000 abstract description 4
- 239000002904 solvent Substances 0.000 abstract description 4
- 238000010586 diagram Methods 0.000 description 14
- 239000007789 gas Substances 0.000 description 14
- 230000000875 corresponding effect Effects 0.000 description 13
- 230000001681 protective effect Effects 0.000 description 9
- 238000007789 sealing Methods 0.000 description 9
- 239000000463 material Substances 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 239000012528 membrane Substances 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 238000007599 discharging Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000004695 Polyether sulfone Substances 0.000 description 2
- 239000012790 adhesive layer Substances 0.000 description 2
- 230000005489 elastic deformation Effects 0.000 description 2
- 210000003128 head Anatomy 0.000 description 2
- 238000003475 lamination Methods 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920006393 polyether sulfone Polymers 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- 229910000619 316 stainless steel Inorganic materials 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 238000010009 beating Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000005056 compaction Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000009963 fulling Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229920003208 poly(ethylene sulfide) Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- -1 polytetrafluoroethylene Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical group FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 description 1
- 238000010415 tidying Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67B—APPLYING CLOSURE MEMBERS TO BOTTLES JARS, OR SIMILAR CONTAINERS; OPENING CLOSED CONTAINERS
- B67B1/00—Closing bottles, jars or similar containers by applying stoppers
- B67B1/04—Closing bottles, jars or similar containers by applying stoppers by inserting threadless stoppers, e.g. corks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67B—APPLYING CLOSURE MEMBERS TO BOTTLES JARS, OR SIMILAR CONTAINERS; OPENING CLOSED CONTAINERS
- B67B3/00—Closing bottles, jars or similar containers by applying caps
- B67B3/02—Closing bottles, jars or similar containers by applying caps by applying flanged caps, e.g. crown caps, and securing by deformation of flanges
- B67B3/10—Capping heads for securing caps
- B67B3/12—Capping heads for securing caps characterised by being movable axially relative to cap to deform flanges thereof, e.g. to press projecting flange rims inwardly
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C3/00—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus; Filling casks or barrels with liquids or semiliquids
- B67C3/02—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus
- B67C3/20—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus with provision for metering the liquids to be introduced, e.g. when adding syrups
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C3/00—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus; Filling casks or barrels with liquids or semiliquids
- B67C3/02—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus
- B67C3/22—Details
- B67C3/24—Devices for supporting or handling bottles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C3/00—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus; Filling casks or barrels with liquids or semiliquids
- B67C3/02—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus
- B67C3/22—Details
- B67C3/26—Filling-heads; Means for engaging filling-heads with bottle necks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C7/00—Concurrent cleaning, filling, and closing of bottles; Processes or devices for at least two of these operations
- B67C7/0006—Conveying; Synchronising
Abstract
Filling, plugging and capping device and method for liquid medicine packaging bottles with protrusions, which belong to the field of medicine packaging machinery, and comprise the following steps: a conveying mechanism; the liquid filling mechanism comprises a liquid filling needle head and a liquid medicine quantitative switch, is connected with the liquid storage tank and is used for quantitatively injecting liquid medicine into an empty penicillin bottle at a liquid filling station; a feeding mechanism; the coating layer pre-pressing mechanism comprises a driving device and a pre-pressing die connected with the driving device; the plugging mechanism is used for pressing the rubber plug into the bottle mouth of the penicillin bottle which is pre-pressed with the coating layer and is positioned at the plugging station; the gland mechanism is used for rolling the aluminum cover onto the mouth of the plugged penicillin bottle at the gland station; and a conveying mechanism. The device and the method of the invention integrally finish the pouring, plugging and capping of the liquid medicine, and achieve the effects that the packaging bottle can solve the problems of verifying air tightness, verifying whether packaging is damaged or not and quickly enabling the evaporated solvent in the injection to drop into the bottle body.
Description
Technical Field
The invention relates to an improvement of a filling, plugging and capping device in liquid medicine packaging, belonging to the field of medicine packaging machinery.
Background
As shown in fig. 5, a typical penicillin bottle (see chinese invention publication CN201445645U, publication 2010.05.05) includes a bottle body 1, a rubber stopper 2, and a cap 3, and a protective cover 4 is sometimes provided on the cap.
In the industry, the liquid medicine, whether the injection for injection administration or the oral liquid for oral administration, is packaged by using the structure.
However, the above-mentioned package has a problem in that it is impossible to quickly know whether it is used or not by appearance: in the case of injections or oral liquids, removal of the protective cap means that the package is unpacked, but it is not easy and quick to detect whether the liquid medicine is sucked by penetration of the syringe needle or other substances are injected. Of course, this can be found by carefully looking at the eye of the needle on the plug 2, but is time consuming and cumbersome.
In addition, the sealing effect of the packaging bottle with the structure is that the rubber plug is plugged on the bottle mouth of the bottle body and then the sealing cover 3 is added for fixing and pressing, but in long-time storage, if leakage occurs, the liquid medicine is deteriorated, and the quick and visual judgment can not be realized through naked eyes.
Disclosure of Invention
The invention provides a filling, plugging and capping device for a liquid medicine packaging bottle with a protrusion, which integrally completes the problems of filling, plugging and capping of the liquid medicine, and the obtained packaging bottle can solve the two problems.
The traditional film-covered rubber plug is directly plugged into the bottle mouth, and the rubber plug of the packaging bottle adopts a deformation pressing process, and any adhesive or other auxiliary agents are used or not used: when the rubber plug is pressed, an elastic coating layer (membrane material) is arranged below the rubber plug, then the coating layer (membrane material) is pre-pressed to obtain a protruding structure, the rubber plug is pressed again, the rubber plug is attached and sealed by using the deformation (plastic deformation and/or elastic deformation) of the membrane material in the pressing process, and the rubber plug is attached and sealed by using the re-deformation (plastic deformation and/or elastic deformation) of the coating layer (membrane material) in the pressing process. In this process, since the hollow structure of the rubber plug and the covering layer are provided with a cavity, in the rapid lamination process, gas (lamination under the protective gas atmosphere) is pressed and sealed in the protruding structure formed by the cavity and the covering layer, so that the internal pressure is larger than the external pressure, and more obvious protrusions or bulges are formed.
The protrusions or bulges are designed for two purposes:
verifying the air tightness and verifying whether the package is destroyed. Since the bulge of the bulge is filled with compressed gas, the bulge height can be pre-determined or marked (marked on the bottle body) according to the operation pressure in the capping operation, and the bulge of the bulge can collapse due to the leakage of the compressed gas once the air tightness is failed or the bulge is used and is punctured (whether malicious or normally used). Thus, by observing whether the bulge of the bulge collapses or not, whether the bulge collapses or not beyond the mark preset on the bottle body can verify the air tightness, whether the package is destroyed or not, and whether the package has been used or not.
Quickly enabling the solvent evaporated in the injection to drop into the bottle body. Since the bulge is approximately V-shaped, solvent (such as volatile ethanol or other volatile component-containing liquid medicine) that condenses by evaporation from the injection liquid in the bottle body can be collected at the lowest point of the center through the bulge, so that the solvent drops more quickly, and the possibility of changing the concentration of the liquid medicine in the bottle body is reduced.
According to the filling and plugging capping device, the coating layer is pre-pressed on the bottle mouth of the penicillin bottle to form the protrusion, then the plugging and capping are performed to complete the filling and sealing operation, the protrusion is more obvious through pre-pressing, the effect is better achieved, and the contrast of naked eyes is more convenient and rapid.
Based on the inventive concept, the invention provides the following experimental scheme.
A filling, stoppering and capping device for a medical fluid packaging bottle having a protuberance, comprising:
the conveying mechanism is used for clamping and fixing the penicillin bottles and moving the penicillin bottles to different stations;
the liquid filling mechanism comprises a liquid filling needle head and a liquid medicine quantitative switch, is connected with the liquid storage tank and is used for quantitatively injecting liquid medicine into an empty penicillin bottle at a liquid filling station;
the feeding mechanism is used for conveying and placing the coating layer on the bottle mouth of the penicillin bottle filled with the liquid medicine at the pre-pressing station;
the covering layer pre-pressing mechanism comprises a driving device and a pre-pressing die connected with the driving device, and is used for pre-pressing the covering layer placed on the bottle mouth of the penicillin bottle at a pre-pressing station into a shape with an arc-shaped protrusion downwards;
the plugging mechanism is used for pressing the rubber plug into the bottle mouth of the penicillin bottle which is pre-pressed with the coating layer and is positioned at the plugging station; and
the capping mechanism is used for rolling the aluminum cap onto the mouth of the plugged penicillin bottle at the capping station.
The purpose of the conveying mechanism is to sequentially convey empty penicillin bottles to a preset station one by one.
Generally, there are two types of conveying mechanisms: a disc type rotary conveying mechanism or a linear conveying mechanism.
The disc type conveying mechanism has the basic principle that a main rotary table is arranged, chucks matched with penicillin bottles are arranged on the periphery of the main rotary table, each penicillin bottle is fed into a bayonet of the chuck through a matched bottle tidying machine, and the penicillin bottles are conveyed to a preset station in rotation. Such mechanisms are commonly used, for example, a double-station penicillin bottle filling machine disclosed in Chinese patent document CN206544899U, a liquid filling and plugging machine disclosed in CN206172956U, a filling and plugging mechanism bottle device disclosed in CN203558514U, a filling and sealing machine disclosed in CN207015615U and a high-speed liquid filling and plugging machine disclosed in CN1431141A all use the disc type conveying mechanism for conveying penicillin bottles.
The linear conveying mechanism is similar to the disc type conveying mechanism, except that a bayonet structure is arranged on a conveying belt, and penicillin bottles are conveyed to a preset station through the movement (intermittent or continuous movement) of the conveying belt.
The liquid filling mechanism is a common injection type filling structure, and a liquid filling needle is driven to be inserted into a bottle opening through an air cylinder, an electric cylinder and the like to perform filling. The quantitative switch is connected to the pipeline of the liquid filling needle head to ensure that the quantity of each filling is a preset quantity.
And the feeding mechanism is used for conveying and placing the coating layer on the bottle mouth of the penicillin bottle filled with the liquid medicine at the pre-pressing station. In general, in a lot of packaging machines for producing products, feeding is performed by an air cylinder, an electric cylinder, an electromagnet, a robot, or the like. In the invention, as the coating layer is conveyed, a proposal is considered that a sucker is arranged on a simple manipulator, and the coating layer is transported to the bottle mouth of the penicillin bottle by the manipulator after being sucked by the sucker.
The plugging mechanism and the capping mechanism use the existing structure, and the liquid filling plugging machine disclosed in CN206172956U, the filling sealing machine disclosed in CN207015615U and the high-speed liquid filling plugging machine disclosed in CN1431141A all disclose corresponding structures and schemes. In general, the plugging mechanism is to plug the rubber plugs which are well aligned (the rubber plugs can be aligned into small heads by a spiral vibration plug alignment machine) into the bottle mouth of the penicillin bottle, and the driving structure is generally an air cylinder. The gland mechanism is to directly press the aluminum cap onto the bottle mouth with the rubber plug, then tighten the lower end of the aluminum cap to shrink and deform the lower end so as to firmly fix the rubber plug on the bottle mouth.
The coating layer prepressing mechanism prepresses the coating layer through a prepressing die to obtain a preliminary protruding shape.
Further, a high pressure gas blowing mechanism is also included, comprising:
the support rod is fixed on the plugging station;
the air blowing ring is a hollow ring, the inner wall of the air blowing ring is provided with an air outlet hole which is communicated with a high-pressure air source through a pipeline, the inner diameter of the air blowing ring is larger than or equal to the bottleneck of the penicillin bottle and is positioned on the bottleneck,
when the penicillin bottle with the pre-pressed coating layer is conveyed to a plugging station by the conveying mechanism, the air blowing ring is just positioned on the bottle mouth and blows air,
the plugging mechanism presses the plug into a bottle mouth while the air blowing ring blows high-pressure air toward the cover layer having an arc-shaped protrusion shape.
Through further design high-pressure gas blowing mechanism, can be after the pre-compaction, blow in high-pressure gas in the protruding structure before the plug, like this when the plug, can make the atmospheric pressure in the protruding bigger, the protruding degree that corresponds also more obvious to reach more audio-visual effect.
Further, the air outlet holes are obliquely downwards arranged, and the air can be blown into the bottle mouth better through the oblique arrangement.
Further, the supporting rod is hollow and tubular, and plays a role of a pipeline, one end of the supporting rod is communicated with the high-pressure air source, and the other end of the supporting rod is communicated with the air blowing ring.
Further, the pre-pressing die comprises a pressing ring and a male die sleeved in the pressing ring,
the upper end of the male die is connected with a first driving device, the compression ring is connected with a second driving device,
the male die can slide up and down in the pressing ring, the lower end of the male die is a convex cambered surface,
when the penicillin bottles are conveyed to the prepressing station, the second driving device drives the pressing ring to press and fix the edges of the covering layers placed on the bottle openings on the lower bottle openings, and the first driving device drives the male dies to penetrate through the pressing ring to press down so as to prepress the covering layers into a shape with arc-shaped protrusions downwards.
Further, a rubber gasket for buffering is arranged on the ground of the compression ring. The rubber gasket is added to compress the covering layer and the covering layer is not pulled or torn due to the fact that the pressing force of the pre-pressing mold is too large and fast.
Preferably, the first driving device and the second driving device are air cylinders or electric cylinders or electromagnets.
Alternatively, the conveying mechanism is a disc type rotary conveying mechanism or a linear conveying mechanism. Screw type conveying mechanisms can of course also be used.
The filling and plugging capping device of AST-3424 injection comprises the filling and plugging capping device of the liquid medicine packaging bottle with the protuberance and a liquid filling pipeline for communicating a liquid storage tank with the liquid storage tank,
wherein the liquid storage tank, the liquid filling pipeline and the liquid filling needle head are all 316-grade stainless steel components; or (b)
The inner layers of the liquid storage tank, the liquid filling pipeline and the liquid filling needle head, which are in contact with the liquid medicine, are polyvinylidene fluoride layers.
Further, the coating layer is a polyvinylidene fluoride layer,
the feeding mechanisms are 316-grade stainless steel components; or the parts of the feeding mechanism contacting the liquid medicine are coated with a polyvinylidene fluoride layer.
It is particularly desirable to use a grade 316 stainless steel or polyvinylidene fluoride layer for some of the components of the cast-in-place capping device that are or may be in contact with the medical fluid for use with an AST-3424 injection because experimental comparison has shown that the medical fluid of AST-3424 does not react with the two materials (8 hours or even 24 hours) to render impurities stable to the medical fluid of AST-3424.
Obviously, the invention also provides a filling, plugging and capping method of the penicillin bottle, which comprises the step of pre-pressing a coating layer:
after the medicine liquid is poured into the penicillin bottle, the coating layer is pre-pressed and molded, so that the coating layer is adhered to the bottle mouth of the penicillin bottle and forms a protruding structure into the bottle mouth.
In general, the method for filling, plugging and capping penicillin bottles mainly comprises a filling step, a plugging step and a capping (capping) step, wherein the step of prepressing the coating layer is to prepress the coating layer to form a protruding structure after the filling step and before the plugging step.
Further, in the plugging step, the rubber plug is quickly pressed into the bottle mouth to which the coating layer is attached. The quick action is to quickly press the gas (protective gas such as nitrogen) in the protruding structure into the bottle mouth through the rubber plug, so that the protruding structure bulges.
Further, when the coating layer is pre-pressed, the coating layer placed on the bottle mouth is fixed and then pre-pressed by using a male die.
Drawings
FIG. 1 is a schematic diagram of a traditional Chinese medicine liquid packaging bottle according to some embodiments of the present invention;
FIG. 2 is a schematic diagram of a specific structure of a traditional Chinese medicine liquid packaging bottle after plugging/capping according to some embodiments of the present invention;
FIG. 3 is a schematic diagram of a rubber plug assembly of a liquid medicine packaging bottle according to some embodiments of the present invention;
FIG. 4 is a schematic diagram of a filling, plugging and capping device in accordance with certain embodiments of the present invention;
FIG. 5 is a schematic illustration of a mechanism for filling liquid according to certain embodiments of the present invention;
FIG. 6 is a schematic illustration of a high pressure gas blowing mechanism in accordance with certain embodiments of the present invention;
FIG. 7 is a schematic illustration of an overlay pre-compression mechanism in accordance with certain embodiments of the present invention;
FIG. 8 is a schematic diagram showing steps of a method for filling, plugging and capping penicillin bottles according to certain embodiments of the present invention;
FIG. 9 is a schematic diagram of a bottle ejection mechanism according to some embodiments of the present invention; and
fig. 10 is a schematic diagram of the operation of the filling, plugging and capping device for a penicillin bottle according to the present embodiment.
Detailed Description
As shown in fig. 1, 2 and 3, the medical fluid packaging bottle 100 comprises a bottle body 10, a rubber plug assembly 20 and a sealing cover 30.
As shown in fig. 2, the bottle body 10 is used for containing a liquid medicine, and includes a bottle neck 12 connected to the bottle body 11, and a bottle mouth 13 is provided at an opening of the bottle neck.
The shape of the bottle 10 is optional depending on the practice, and is generally cylindrical or rectangular. Moreover, the neck 12 is generally smaller than the body 11, and is specifically shaped as shown in fig. 2.
The rubber plug assembly 20 is used for being plugged into the bottle mouth 11 of the bottle body 10, and comprises a rubber plug 21 and a coating layer 22 directly attached to the exposed surface of the rubber plug facing the bottle mouth, wherein an adhesive layer is not arranged between the coating layer and the rubber plug or an inert adhesive layer is used.
The coating layer 22 is an elastic polymer material layer for medical use, and is preferably prepared by using a polyether sulfone resin PES, polytetrafluoroethylene PTFE, polyvinylidene fluoride PVDF, and tetrafluoroethylene/hexafluoropropylene copolymer FEP film material. The rubber plug 21 is made of elastic material.
As shown in fig. 1, the sealing cap 30 is configured to be disposed on the rubber plug assembly 20 to fix the bottle mouth 13 and the rubber plug assembly 20 in a clamping manner.
As shown in fig. 2, the upper end of the ring-shaped ring is sleeved on the rubber plug assembly 20, meanwhile, the lower end of the ring-shaped ring is clamped on the bottle neck 12, and a circle of concave 122 is formed on the bottle neck 12 and is used for clamping and hooking the lower end of the sealing cover 30, so that the rubber plug assembly 20 can be firmly plugged into and fixed in the bottle mouth 13.
The cover 30 is typically made of aluminum. A notch 31 (circular hole) is formed at the top of the cover 30 to expose the rubber plug 21 for easy puncture.
As shown in fig. 3, the rubber plug 21 includes a base 211 and a plug body 212 connected to the base, and an outer end surface of the plug body 212 has a concave structure 213.
Correspondingly, the covering layer 22 is at least bonded to the surface of the plug 212, but does not adhere to the inner wall formed by the recess structure 213, so that a closed cavity 214 is formed between the recess structure 213 and the covering layer 22.
As shown in fig. 1, the cover layer 22 is outwardly protruded due to the compressed gas in the closed cavity 214 formed between the recess structure 213 and the cover layer 22.
Example 2
As shown in fig. 1, the packaging bottle 100 further includes a protective cap 40, and the protective cap 40 has a cylindrical cap portion 41 and a ring-shaped neck-receiving portion 42 connected to the cylindrical cap portion, the cylindrical cap portion 41 being for covering the base 211, and the neck-receiving portion 42 being for covering the bottle mouth 13.
The protective cover 40 is fastened to and covers the notch 31 (circular hole) formed at the top of the cover 30 so that the exposed rubber plug 21 is covered.
Example 3
As the summary of the invention suggests, in order to make the above-mentioned bulge or position change of bulge more intuitive, graduation lines are provided on the body 11 or neck 12 portion of the bottle (penicillin bottle) to mark the design position of the bulge or bulge. As shown in fig. 1, the graduation mark 121 is a frosted ring band having a width of 1.5mm, and the ring band is frosted at intervals, so that the positions of the alignment protrusions or bulges can be easily observed.
The above embodiments give the structure of the liquid medicine packaging bottle with the protrusion, and the following embodiments specifically describe the specific structure of the filling, plugging and capping device of the liquid medicine packaging bottle with the protrusion.
Example 4
As shown in fig. 4, the filling, capping device 1000 of the liquid medicine packaging bottle having a protrusion includes:
and the conveying mechanism 200 is used for clamping and fixing the penicillin bottles and moving to different stations. In this embodiment, a disc type conveying mechanism with a relatively compact structure is selected, and the basic principle is that a main rotary table 210 is provided, chucks 220 matched with penicillin bottles are arranged around the main rotary table, and individual penicillin bottles are conveyed to a preset station in rotation by arranging individual penicillin bottles Lin Pingka into bayonets of the chucks through a matched bottle arranging machine LB. Correspondingly, the predetermined stations are also arranged circumferentially. Of course, according to the different corresponding action mechanisms set on each station, the number of bayonets driven by the driving machine (stepping motor) corresponding to the conveying mechanism 10 is also different, for example, if 60 bayonets are set on one chuck 220, the corresponding angle of each corresponding bayonet is 6 degrees, if 10 filling mechanisms 300, feeding mechanisms 400, cover layer pre-pressing mechanisms 500, plugging mechanisms 600 and capping mechanisms 700 are set on one station, the driving machine drives the turntable 210 to rotate 60 degrees each time; if one station is provided with 5 of the various mechanisms described above, the drive motor drives the turntable 210 30 degrees at a time, and so on. In this embodiment, 30 bayonets 221 are provided on one chuck 220, and then the corresponding angle of each corresponding bayonet is 12 degrees, and 1 filling mechanism 300, feeding mechanism 400, coating pre-pressing mechanism 500, plugging mechanism 600, and capping mechanism 700 are provided on one station to perform corresponding operations at the same time, so that each time the driving machine drives the turntable 210 to rotate 12 degrees.
The liquid filling mechanism 300 comprises a liquid filling needle head 310 and a liquid medicine quantitative switch 320, is connected with the liquid storage tank C and is used for quantitatively injecting liquid medicine into an empty penicillin bottle at a liquid filling station. The conventional structural scheme is used in this embodiment, as shown in fig. 5: the liquid medicine in the liquid storage tank C stored with the injection is quantitatively injected into an empty penicillin bottle through the liquid filling needle 310 under the action of the pump and the liquid medicine quantitative switch 320.
And the feeding mechanism 400 is used for conveying and placing the coating layer on the bottle mouth of the penicillin bottle filled with the liquid medicine at the prepressing station. In the feeding mechanism of the embodiment, as the coating layer is to be conveyed, the proposal is considered that a sucker is arranged on a simple manipulator, and the coating layer is transported to the bottle mouth of the penicillin bottle by means of the manipulator after being sucked by the sucker.
The cover layer pre-pressing mechanism 500 comprises a driving device 510 and a pre-pressing die 520 connected with the driving device, and is used for pre-pressing the cover layer placed on the bottle mouth of the penicillin bottle at the pre-pressing station into a shape with an arc-shaped protrusion downwards.
The plugging mechanism 600 is used for pressing the rubber plug into the bottle mouth of the penicillin bottle which is pre-pressed with the coating layer and is positioned at the plugging station.
The capping mechanism 700 is used for rolling the aluminum cap onto the mouth of the plugged penicillin bottle at the capping station.
The plugging mechanism and the capping mechanism use the structure which is supplied on the existing market, and the liquid filling plugging machine disclosed in CN206172956U, the filling sealing machine disclosed in CN207015615U and the high-speed liquid filling plugging machine disclosed in CN1431141A all disclose corresponding structures and schemes. In general, the plugging mechanism is to plug the rubber plugs which are well aligned (the rubber plugs can be aligned into small heads by a spiral vibration plug alignment machine) into the bottle mouth of the penicillin bottle, and the driving structure is generally an air cylinder. The gland mechanism is to directly press the aluminum cap onto the bottle mouth with the rubber plug, then tighten the lower end of the aluminum cap to shrink and deform the lower end so as to firmly fix the rubber plug on the bottle mouth.
Example 5
On the basis of the above-described embodiment 4, as shown in fig. 4/6, there is further included a high-pressure gas blowing mechanism 800 including:
a support bar 810 secured to the tucking station.
The air blowing ring 820 is a hollow ring, the inner wall of which is provided with an air outlet hole 821 which is communicated with the high-pressure air source G through a pipeline, and the inner diameter of the air blowing ring is larger than or equal to the bottleneck of the penicillin bottle and is positioned on the bottleneck.
When the penicillin bottle with the pre-pressed coating layer is conveyed to a plugging station by the conveying mechanism 200, the air blowing ring is just positioned on the bottle mouth and blows air, and when the air blowing ring 820 blows high-pressure air towards the coating layer with the arc-shaped protrusion shape, the plugging mechanism 600 presses the rubber plug into the bottle mouth.
Example 6
On the basis of the embodiment 4 and/or 5, the air outlet holes are arranged obliquely downwards, specifically, holes are arranged on the inner wall of the air blowing ring, and then short pipes are welded and arranged obliquely downwards.
Detailed description 7
On the basis of the above embodiments 4 and/or 5 and/or 6, the support rod 810 is hollow and tubular, and functions as a pipe, one end of which is connected to the high-pressure air source, and the other end of which is connected to the air blowing ring.
Example 8
On the basis of the above embodiments 4 and/or 5 and/or 6 and/or 7, as shown in fig. 7, the driving device 510 is disposed on a support 530, and the support 530 is fixed on the pre-pressing station. The pre-pressing die 520 comprises a pressing ring 521 and a male die 522 sleeved in the pressing ring.
The upper end of the male die 522 is connected to the first driving device 511, and the pressing ring 521 is connected to the second driving device 512. The male die 522 can slide up and down in the compression ring 521, and the lower end of the male die is a convex cambered surface.
When the penicillin bottles are conveyed to the pre-pressing station, the second driving device 512 drives the pressing ring 521 to press and fix the edges of the covering layers placed on the bottle openings on the lower bottle openings, and the first driving device 511 drives the male dies 522 to press down through the pressing ring 521 to pre-press the covering layers 22 into shapes with arc-shaped protrusions downwards.
Example 9
In the above embodiments 4 and/or 5 and/or 6 and/or 7 and/or 8, a rubber gasket for cushioning is provided on the bottom surface of the pressing ring 521.
Example 10
On the basis of the above embodiments 4 and/or 5 and/or 6 and/or 7 and/or 8 and/or 9, the first driving device 511 and the second driving device 512 are air cylinders or electric cylinders or electromagnets or electric push rods.
Since the first driving device 511 is used for driving the male die 522 to perform film pressing, and the speed and the force of the male die during film pressing directly affect the shape of the laminated layer to be pressed, too fast or too strong force will cause the stretching or breaking, it is preferable that the first driving device 511 uses an electric cylinder capable of precisely controlling the force and the action speed, and a servo electric cylinder is preferable.
Example 11
The filling, plugging and capping device for the AST-3424 injection comprises the filling, plugging and capping device for the liquid medicine packaging bottle with the protrusion in any one of the specific embodiments 4-10 and a liquid filling pipeline G for communicating a liquid storage tank C with the liquid storage tank, wherein the liquid storage tank C, the liquid filling pipeline G and the liquid filling needle 310 are all 316-grade stainless steel components; or the inner layers of the liquid storage tank C, the liquid filling pipeline and the liquid filling needle head 310 which are contacted with the liquid medicine are polyvinylidene fluoride layers.
Example 12
On the basis of embodiment 10, the cover layer is a polyvinylidene fluoride layer,
the feeding mechanisms 400 are all 316-grade stainless steel components; or the parts of the feeding mechanism 400 contacting the liquid medicine are coated with a polyvinylidene fluoride layer.
Example 13
As shown in fig. 8, the present embodiment provides a method for filling, plugging and capping penicillin bottles, which sequentially includes a filling step S1, a coating layer pre-pressing step S2, a plugging step S3 and a capping step S4.
And (S1) pouring the liquid medicine with a preset volume into the penicillin bottle through a liquid pouring mechanism.
And S2, pre-pressing the coating layer, namely pre-pressing and forming the coating layer after the liquid medicine is poured into the penicillin bottle, so that the coating layer is attached to the bottle mouth of the penicillin bottle and forms a protruding structure into the bottle mouth.
Preferably, when the coating layer is pre-pressed, the coating layer placed on the bottle mouth is fixed and then pre-pressed by using a male die.
And S3, rapidly pressing the rubber plug into the bottle mouth to which the coating layer is attached. The rapid rate is within 0.1 seconds or more.
And a capping step S4, namely directly pressing the aluminum cap onto the bottle mouth with the rubber plug plugged, and then tightening the lower end of the aluminum cap to enable the lower end to shrink and deform so as to firmly fix the rubber plug on the bottle mouth.
The operation of the whole device will be described with reference to fig. 4 and fig. 8 and 10.
The cleaned penicillin bottles are slowly pushed into the bayonets of the chuck 220 by the push rod of the bottle unscrambler L in the hopper LD of the bottle unscrambler L. Then is conveyed by a chuck of the conveying mechanism 200, and is filled by the filling mechanism when conveyed to a filling station corresponding to the corresponding filling mechanism 300 (a picture);
the chuck continues to rotate, the penicillin bottles after filling are conveyed to a beating and prepressing station, the feeding mechanism 400 acts, and the coating layer 22 is placed on the western Lin Pingkou (b diagram);
after the coating layer is placed, the pressing ring 521 of the coating layer prepressing mechanism 500 is driven to fix the periphery of the coating layer on the penicillin bottle opening (c diagram), and then the male mold 522 is driven to prepress the coating layer (d diagram);
the chuck continues to rotate, the penicillin bottle is conveyed to a plugging station, the high-pressure gas blowing mechanism 800 acts to blow (e diagram), and after the high-pressure gas blowing mechanism leaves, the plugging mechanism 600 presses the rubber plug in (f diagram);
after the chuck rotates to convey the plugged penicillin bottles to the capping station, the capping mechanism 700 acts to complete capping (g diagram), and the protective cover pressing mechanism BH presses the protective cover (h diagram) immediately, so that the packaging bottles shown in fig. 2 are finally obtained.
The chuck of the conveying mechanism 200 continues to rotate, and the capped penicillin bottles are conveyed to the bottle outlet mechanism 900.
As shown in fig. 9, a bottle pulling plate is disposed at the edge of the hopper LD, the bottle pulling plate 910 is in a folded line shape or an arc shape towards the chuck 220, the tip end of the bottle pulling plate extends into the bayonet 221 of the chuck 220, a chamfer (round chamfer or right angle chamfer) is disposed at one edge of the corresponding bayonet towards the bottle pulling plate, and the design of the chamfer facilitates the bottle pulling plate to be inserted into the bayonet 221 to pull out the penicillin bottles.
When the chuck 220 continues to rotate to the corresponding station of the bottle discharging mechanism 900, the bottle pulling plate 910 will pull out the penicillin bottles clamped in the bayonet 221 one by one into the bottle discharging channel 920, thus completing the bottle discharging process.
Claims (11)
1. A filling, stoppering and capping device for a medical fluid packaging bottle having a protuberance, comprising:
the conveying mechanism is used for clamping and fixing the penicillin bottles and moving to different stations, and is a disc type rotary conveying mechanism or a linear conveying mechanism;
the liquid filling mechanism comprises a liquid filling needle head and a liquid medicine quantitative switch, is connected with the liquid storage tank and is used for quantitatively injecting liquid medicine into an empty penicillin bottle at a liquid filling station;
the feeding mechanism is used for conveying and placing the coating layer on the bottle mouth of the penicillin bottle filled with the liquid medicine at the pre-pressing station;
the covering layer pre-pressing mechanism comprises a driving device and a pre-pressing die connected with the driving device, and is used for pre-pressing the covering layer placed on the bottle mouth of the penicillin bottle at a pre-pressing station into a shape with an arc-shaped protrusion downwards;
the plugging mechanism is used for pressing the rubber plug into the bottle mouth of the penicillin bottle which is pre-pressed with the coating layer and is positioned at the plugging station;
the capping mechanism is used for rolling the aluminum cap onto the mouth of the plugged penicillin bottle at the capping station; and
a high pressure gas blowing mechanism comprising:
a supporting rod fixed on the plugging station,
the air blowing ring is a hollow ring, the inner wall of the air blowing ring is provided with an air outlet hole which is communicated with a high-pressure air source through a pipeline, the inner diameter of the air blowing ring is larger than or equal to the bottleneck of the penicillin bottle and is positioned on the bottleneck,
when the penicillin bottle with the pre-pressed coating layer is conveyed to a plugging station by the conveying mechanism, the air blowing ring is just positioned on the bottle mouth and blows air,
when the blowing ring blows high-pressure gas to the covering layer with the arc-shaped protruding shape, the plug adding mechanism presses the rubber plug into a bottle opening.
2. The filling, plugging and capping device according to claim 1, wherein the air outlet holes are arranged obliquely downwards.
3. The filling, plugging and capping device according to claim 1, wherein the support rod is hollow and tubular and functions as a pipeline, one end of the support rod is communicated with the high-pressure air source, and the other end of the support rod is communicated with the air blowing ring.
4. The filling, plugging and capping device according to claim 1, wherein the pre-pressing die comprises a pressing ring and a male die sleeved in the pressing ring,
the upper end of the male die is connected with a first driving device, the compression ring is connected with a second driving device,
the male die can slide up and down in the pressing ring, the lower end of the male die is a convex cambered surface,
when the penicillin bottles are conveyed to the prepressing station, the second driving device drives the pressing ring to press and fix the edges of the covering layers placed on the bottle openings on the lower bottle openings, and the first driving device drives the male dies to penetrate through the pressing ring to press down so as to prepress the covering layers into a shape with arc-shaped protrusions downwards.
5. The filling, plugging and capping device according to claim 4, wherein a rubber gasket for buffering is provided on a bottom surface of the pressure ring.
6. The priming capping device of claim 4, wherein the first drive means, the second drive means are air cylinders or electric cylinders or electromagnets.
An AST-3424 injection filling, plugging and capping device comprising the filling, plugging and capping device with the protruding liquid medicine packaging bottle as claimed in any one of claims 1-6 and a liquid filling pipeline for communicating a liquid storage tank with the liquid storage tank,
wherein the liquid storage tank, the liquid filling pipeline and the liquid filling needle head are all 316-grade stainless steel components;
or (b)
The inner layers of the liquid storage tank, the liquid filling pipeline and the liquid filling needle head, which are in contact with the liquid medicine, are polyvinylidene fluoride layers.
8. The infusion capping device of claim 7, wherein the cover layer is a polyvinylidene fluoride layer,
the feeding mechanisms are 316-grade stainless steel components; or the parts of the feeding mechanism contacting the liquid medicine are coated with a polyvinylidene fluoride layer.
9. A method for filling, plugging and capping penicillin bottles, using the filling, plugging and capping device for liquid medicine packaging bottles with protrusions according to any one of claims 1 to 6, comprising a coating layer pre-pressing step:
after the medicine liquid is poured into the penicillin bottle, the coating layer is pre-pressed and molded, so that the coating layer is adhered to the bottle mouth of the penicillin bottle and forms a protruding structure into the bottle mouth.
10. The method of filling, plugging and capping as in claim 9, wherein the plugging step is performed by rapidly pressing the plug into the mouth of the bottle to which the coating is applied.
11. The filling, capping method according to claim 9, wherein the capping layer placed on the bottle mouth is fixed and then pre-pressed using a male mold when pre-pressing the capping layer is performed.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910837741.8A CN111572833B (en) | 2019-09-05 | 2019-09-05 | Filling, plugging and capping device and method for liquid medicine packaging bottle with protrusions |
| PCT/CN2020/113550 WO2021043275A1 (en) | 2019-09-05 | 2020-09-04 | Packaging bottle and packaging kit for injection, and filling, stoppering and capping device and method |
| TW109130514A TW202110415A (en) | 2019-09-05 | 2020-09-04 | Packaging bottle and packaging kit for injection, and filling, stoppering and capping device and method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910837741.8A CN111572833B (en) | 2019-09-05 | 2019-09-05 | Filling, plugging and capping device and method for liquid medicine packaging bottle with protrusions |
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| CN111572833B true CN111572833B (en) | 2024-02-09 |
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| TW202110415A (en) * | 2019-09-05 | 2021-03-16 | 大陸商深圳艾欣達偉醫藥科技有限公司 | Packaging bottle and packaging kit for injection, and filling, stoppering and capping device and method |
| CN114655911B (en) * | 2022-05-07 | 2024-01-26 | 山东玉满坤生物科技有限公司 | Filling equipment is used in injection production |
| CN115367169B (en) * | 2022-09-26 | 2023-11-07 | 江苏先通分子影像科技有限公司 | Automatic injection split charging equipment |
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