CN111551881B - Nuclear magnetic resonance magnetic field measurement method and system based on particle accelerator - Google Patents
Nuclear magnetic resonance magnetic field measurement method and system based on particle accelerator Download PDFInfo
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Abstract
The utility model discloses a nuclear magnetic resonance magnetic field measurement method and system based on a particle accelerator, which comprises the following steps: emitting accelerated particles to a region to be measured of a nuclear magnetic resonance instrument by using a particle accelerator; recording the motion track and the track change point of the accelerated particles in the area to be measured; changing the emission angle of the particle accelerator, and emitting accelerated particles to the region to be measured of the nuclear magnetic resonance instrument again; recording the motion track and the track change point of the accelerated particles in the area to be measured after the emission angle is changed; repeating the previous step for a set number of times; then, for each motion track, calculating the magnetic field intensity of the current motion track by using a magnetic deflection method; for each track change point, calculating the magnetic field intensity of the current track change point by using a hydrogen atomic nuclear spin method; and drawing a magnetic field intensity boundary line based on the magnetic field intensity of all the motion tracks and the magnetic field intensity of all the track points to obtain the magnetic field intensity of the region to be measured of the nuclear magnetic resonance instrument.
Description
Technical Field
The disclosure relates to the technical field of medical equipment, in particular to a nuclear magnetic resonance magnetic field measurement method and system based on a particle accelerator.
Background
The statements in this section merely provide background information related to the present disclosure and may not constitute prior art.
With the development of the times, the medical technology is also continuously improved in the face of the increasing number of tumor diseases. Through an electronic slip ring, a radiotherapy instrument is combined with a nuclear magnetic resonance instrument, and the obtained magnetic resonance accelerator can achieve the effect of positioning and radiotherapy. However, because the nmr is inside the electronic slip ring and works to generate a magnetic field, the hydrogen nuclei in the human body in the magnetic field are excited to cause the hydrogen nuclei to resonate and absorb energy, and the accelerated particles generated by the external particle accelerator are injected into the human body. In order to avoid the deflection of particles due to the Lorentz force generated by the particles passing through the magnetic field during the process of entering the human body, a magnetic field detection method is needed to accurately calibrate and detect the magnetic field in the nuclear magnetic resonance instrument.
The inventor finds that the traditional detection method is complex and can be completed only by assistance of other tools, and is obviously not suitable for a system in which a particle accelerator and a nuclear magnetic resonance spectrometer are combined.
Disclosure of Invention
In order to solve the deficiencies of the prior art, the present disclosure provides a nuclear magnetic resonance magnetic field measurement method and system based on a particle accelerator; the particle accelerator in the combined structure can be effectively utilized, and local materials can be obtained; and the boundary points are calculated by another method, so that the measurement of the measured magnetic field is more accurate and simpler.
In a first aspect, the present disclosure provides a particle accelerator-based nuclear magnetic resonance magnetic field measurement method;
the nuclear magnetic resonance magnetic field measurement method based on the particle accelerator comprises the following steps:
emitting accelerated particles to a region to be measured of a nuclear magnetic resonance instrument by using a particle accelerator; recording the motion track and the track change point of the accelerated particles in the area to be measured;
an angle changing step: changing the emission angle of the particle accelerator, and emitting accelerated particles to the region to be measured of the nuclear magnetic resonance instrument again; recording the motion track and the track change point of the accelerated particles in the area to be measured after the emission angle is changed;
repeating the angle changing step for a set number of times; then, for each motion track, calculating the magnetic field intensity of the current motion track by using a magnetic deflection method; for each track change point, calculating the magnetic field intensity of the current track change point by using a hydrogen atomic nuclear spin method;
and drawing a magnetic field intensity boundary line based on the magnetic field intensity of all the motion tracks and the magnetic field intensity of all the track change points to obtain the magnetic field intensity of the region to be measured of the nuclear magnetic resonance instrument.
In a second aspect, the present disclosure provides a particle accelerator-based magnetic resonance magnetic field measurement system;
a nuclear magnetic resonance magnetic field measurement system based on a particle accelerator, comprising:
a transmit module configured to: emitting accelerated particles to a region to be measured of a nuclear magnetic resonance instrument by using a particle accelerator; recording the motion track and the track change point of the accelerated particles in the area to be measured;
an angle change module configured to: changing the emission angle of the particle accelerator, and emitting accelerated particles to the region to be measured of the nuclear magnetic resonance instrument again; recording the motion track and the track change point of the accelerated particles in the area to be measured after the emission angle is changed;
a magnetic field strength calculation module configured to: repeating the angle changing step for a set number of times; then, for each motion track, calculating the magnetic field intensity of the current motion track by using a magnetic deflection method; for each track change point, calculating the magnetic field intensity of the current track change point by using a hydrogen atomic nuclear spin method;
an output module configured to: and drawing a magnetic field intensity boundary line based on the magnetic field intensity of all the motion tracks and the magnetic field intensity of all the track change points to obtain the magnetic field intensity of the region to be measured of the nuclear magnetic resonance instrument.
In a third aspect, the present disclosure also provides an electronic device comprising a memory and a processor, and computer instructions stored on the memory and executed on the processor, wherein when the computer instructions are executed by the processor, the method of the first aspect is performed.
In a fourth aspect, the present disclosure also provides a computer-readable storage medium for storing computer instructions which, when executed by a processor, perform the method of the first aspect.
Compared with the prior art, the beneficial effect of this disclosure is:
1. the magnetic field is measured in the particle accelerator of the combined particle accelerator and nuclear magnetic resonance spectrometer, and the particle accelerator is reasonably and effectively utilized, so that the measurement of the magnetic field is more accurate.
2. According to the method, the movement track and the track change point of the accelerated particles in the area to be measured are recorded, so that the recording and the measurement of the movement track of the particles are more accurate, the accuracy of magnetic field measurement is improved, and a reasonable coordinate system is combined, so that the accurate calibration of a magnetic field can be realized.
3. The method combines a magnetic deflection method and a hydrogen atomic nuclear spinning method, adopts different methods for different areas, and repeatedly measures the boundary area with changed magnetic field, so that the boundary track with changed magnetic field is clearer.
4. The hydrogen nuclear spin method adopted by the method accords with the positioning principle of nuclear magnetic resonance for medical tumor images, and can be mastered more quickly and operated and calculated more familiar to users.
Drawings
The accompanying drawings, which are included to provide a further understanding of the disclosure, illustrate embodiments of the disclosure and together with the description serve to explain the disclosure and are not to limit the disclosure.
Fig. 1 is a flow chart of magnetic field measurement by magnetic deflection method according to a first embodiment of the present disclosure;
FIG. 2 is a flow chart of magnetic field measurement by hydrogen nuclear spin method according to a first embodiment of the disclosure;
FIG. 3 is a flowchart illustrating a process for processing the obtained data according to a first embodiment of the disclosure;
fig. 4 is an overall flowchart of the method according to the first embodiment of the disclosure.
Detailed Description
It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the disclosure. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs.
It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments according to the present disclosure. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise.
As described in the background, the existing magnetic field detection technology is complicated and requires other instruments to be connected, and it is obviously not suitable for the assembled device to be measured after being disassembled. In order to solve the problems, the disclosure provides a nuclear magnetic resonance magnetic field measurement and correction method and system based on a particle accelerator.
In a first embodiment, the present embodiment provides a nuclear magnetic resonance magnetic field measurement method based on a particle accelerator;
as shown in fig. 4, the nuclear magnetic resonance magnetic field measurement method based on the particle accelerator includes:
s1: emitting accelerated particles to a region to be measured of a nuclear magnetic resonance instrument by using a particle accelerator; recording the motion track and the track change point of the accelerated particles in the area to be measured;
s2: changing the emission angle of the particle accelerator, and emitting accelerated particles to the region to be measured of the nuclear magnetic resonance instrument again; recording the motion track and the track change point of the accelerated particles in the area to be measured after the emission angle is changed;
s3: repeating S2 for a set number of times; then, for each motion track, calculating the magnetic field intensity of the current motion track by using a magnetic deflection method; for each track change point, calculating the magnetic field intensity of the current track change point by using a hydrogen atomic nuclear spin method;
s4: and drawing a magnetic field intensity boundary line based on the magnetic field intensity of all the motion tracks and the magnetic field intensity of all the track change points to obtain the magnetic field intensity of the region to be measured of the nuclear magnetic resonance instrument.
As one or more embodiments, the method further comprises:
s5: applying reverse magnetic field intensity to a region to be measured of the nuclear magnetic resonance apparatus;
emitting accelerated particles to a region to be measured of a nuclear magnetic resonance instrument by using a particle accelerator; recording the motion track of the accelerated particles in the region to be measured;
s6: judging the size of the track deflection angle and a set threshold, and returning to S1 if the track deflection angle is larger than the set threshold; if the track deflection angle is smaller than the set threshold value, correcting the intensity of the reverse magnetic field intensity, and returning to S5; if the track deflection angle is zero, the process is ended and the applied reverse magnetic field strength is output.
As one or more embodiments, the region to be measured is a region of a magnetic field generated by operation of a Magnetic Resonance Imaging (MRI) instrument, the magnetic field having a strength of about 1.5 tesla.
As one or more embodiments, the recording of the motion trajectory and the trajectory change point of the accelerated particles in the region to be measured is performed by using a high-energy particle detector.
It will be appreciated that a high energy particle detector may be used to display the distribution and motion profile of the observed particles.
As one or more embodiments, as shown in fig. 1, in S3, for each motion trajectory, calculating the magnetic field strength of the current motion trajectory by using a magnetic deflection method; the method specifically comprises the following steps:
charged particles vertically enter a magnetic field, deflect due to Lorentz force and do uniform-speed circular motion;
according to the track, measuring the time t, the distance s and the circumferential radius r of uniform-speed circular motion, and calculating the corresponding magnetic field by combining the known nuclear-mass ratio q/m:
B＝ms/qrt。
it should be understood that the magnetic deflection method can measure the magnetic field size of a certain area by accelerating the particle motion trajectory, and if the particle motion trajectory is a perfect circle, the certain area is a uniform magnetic field.
Preferably, in S3, for each motion trajectory, calculating the magnetic field strength of the current motion trajectory by using a magnetic deflection method; the method specifically comprises the following steps:
taking the boundary point as a boundary, dividing the particle motion track into two arcs, respectively measuring the motion time, the corresponding central angle and the radius of the two arcs for a plurality of times, and obtaining a plurality of groups of magnetic field strengths corresponding to the two arcs according to a plurality of groups of data of the two arcs:
averaging the magnetic field strengths of the multiple groups:
to remove significant errors, if | Bi-B*|>λ, then, the measured B is indicatediIf the error is too large, discarding the error, wherein lambda is a constant;
then, the rest data is subjected to averaging processing to obtain the magnetic field intensity corresponding to the two arcs, the two obtained magnetic field intensities can form a range, and the actual magnetic field intensity is within the range.
As one or more embodiments, in S3, as shown in fig. 2, for each trajectory change point, the calculating the magnetic field strength of the current trajectory change point by using the hydrogen nuclear spin method specifically includes:
placing hydrogen nuclei at the current trajectory change point, and calculating the spin magnetic moment of the hydrogen nuclei:
μ＝epg/2M，
wherein e is the charge of the hydrogen nuclei, M is the mass of the hydrogen nuclei, and g is a constant determined by the nuclear structure;
p is the discrete value of the nuclear angular momentum;
where I is a spin quantum number, I is 0, 1/2, 1, 3/2, 2, 5/2 … …), and a resonance condition is obtained from the interaction between the magnetic moment and the applied magnetic field, that is, the magnitude of the magnetic field at the corresponding point can be calculated.
At the trajectory change point, a hydrogen nucleus is placed, and the presence or absence or magnitude of the magnetic field at that point is calculated from the spin condition of the hydrogen nucleus.
The method comprises the steps of placing an external hydrogen atomic nucleus at a demarcation point by using a hydrogen atomic nucleus spinning method, measuring and calculating the spinning magnetic moment value of the light atomic nucleus, measuring for multiple times to obtain multiple groups of data, calculating to obtain multiple magnetic field strength values, removing obvious error and magnetic field strength values with the size outside the range, then carrying out averaging treatment, and taking the obtained average value as the magnetic field strength value of the point.
It will be appreciated that the hydrogen nuclear spin method is typically used to measure for one point.
It should be understood that if only the magnetic deflection method is adopted for measurement, the measurement error is larger at the position where the particle motion track changes and the position where the track arc is smaller; if only the hydrogen nuclear spin method is used for measurement, each point in the measurement space needs to be measured, and a great deal of time and effort is required. The two methods are combined and complement each other, so that the measurement precision can be increased, and the measurement time can be shortened.
It should be understood that the trajectory change point is a boundary point of the magnetic field change, and the trajectory of the particle changes, and cannot be accurately measured only by the magnetic deflection method. And performing fixed-point measurement on the points by using a hydrogen atomic nuclear spin method to determine the change condition of the magnetic field.
The present disclosure combines two magnetic field measurement methods: magnetic deflection methods and hydrogen nuclear spin methods. The two algorithms are combined with a reasonable coordinate system, and a simulation model is constructed to detect the obtained data, so that the accurate calibration of the magnetic field can be completed. In the assembled instrument, the particle accelerator connected with the nuclear magnetic resonance instrument is fully utilized.
As one or more embodiments, as shown in fig. 3, the specific step of S3 includes:
the interaction of magnetic field B with magnetic moment can be:
E＝-μ×B＝-μZB＝-γPZB＝-γmhB
wherein m is the number of quanta;
ΔE＝γhB
energy separation between adjacent energy levels.
The nuclear magnetic resonance instrument works to generate a radio frequency field, and the radio frequency field meets the resonance condition:
v＝γB/2π，
by measuring the resonance frequency v of the particles in the corresponding magnetic fieldHFinding the corresponding magnetic field:
B＝vH2π/γ。
and magnetic field intensity measured by a magnetic deflection method and a hydrogen atomic nuclear spin method is measured for multiple times, and the magnetic field intensity at any point is obtained by combining a plane rectangular coordinate system.
The magnetic field accurate calibration and detection method can be used for detecting the magnetic field in accelerator equipment combining nuclear magnetic resonance and radiotherapy, reasonably utilizes a particle accelerator, combines two magnetic field measurement methods and coordinate system calibration, and can simply and accurately perform magnetic field calibration and measurement on the accelerator equipment combining nuclear magnetic resonance and radiotherapy.
The size and distribution of a magnetic field in nuclear magnetic resonance are measured by adopting a particle accelerator combined with a nuclear magnetic resonance instrument, namely, accelerated particles are emitted by the particle accelerator, and the size, the direction and the change condition of the magnetic field at the corresponding position are judged and calculated according to the obtained particle motion trail and the spinning condition of an externally added hydrogen atom at the position where the magnetic field needs to be detected.
After a space rectangular coordinate system is established, the combined particle accelerator is used for emitting accelerated particles, the magnetic field strength of a point is calculated by a magnetic deflection method, then hydrogen atomic nuclei are placed aiming at the boundary where the magnetic field is transformed, and the calculation is carried out again by a hydrogen atomic nucleus spinning method. The calculation of the two methods can be repeated to obtain the final result. And (3) processing the boundary of the magnetic field change again, calculating a curve equation of the boundary by using a computer, constructing a virtual model of the whole magnetic field, emitting accelerated particles by adding an equal-strength reverse magnetic field, and observing whether the track of the accelerated particles deflects or not to detect the measured data so as to ensure the accuracy of the measured data.
The digital magnetic field model is established, and a reverse magnetic field is added for detection, so that the condition of inconvenient detection caused by combination with an accelerator is avoided.
The method comprises the steps of measuring and calculating the magnetic field intensity by using a magnetic deflection method and a hydrogen atomic nuclear spinning method, combining the two methods for the magnetic field change point position, drawing a boundary line of the magnetic field change by combining a space rectangular coordinate system, calculating an equation corresponding to the boundary line, manufacturing a corresponding magnetic field intensity model, applying an equal-intensity reverse applied magnetic field, and judging the accuracy of a calibration and detection result according to the motion trajectory of particles at the moment.
If the data is correct, the field intensity of each point of the whole magnetic field can be obtained;
if the detection result of a certain part has deviation, if the deviation is larger, the part can be measured again and detected again;
if the deviation is small, the reverse magnetic field value can be directly adjusted up or down by taking the finally calculated numerical value as a reference, so that the particle track has no deflection, and the adjusted reverse magnetic field strength value is the final measurement value.
In a second embodiment, the present embodiment provides a nuclear magnetic resonance magnetic field measurement system based on a particle accelerator;
a nuclear magnetic resonance magnetic field measurement system based on a particle accelerator, comprising:
a transmit module configured to: emitting accelerated particles to a region to be measured of a nuclear magnetic resonance instrument by using a particle accelerator; recording the motion track and the track change point of the accelerated particles in the area to be measured;
an angle change module configured to: changing the emission angle of the particle accelerator, and emitting accelerated particles to the region to be measured of the nuclear magnetic resonance instrument again; recording the motion track and the track change point of the accelerated particles in the area to be measured after the emission angle is changed;
a magnetic field strength calculation module configured to: repeating the angle changing step for a set number of times; then, for each motion track, calculating the magnetic field intensity of the current motion track by using a magnetic deflection method; for each track change point, calculating the magnetic field intensity of the current track change point by using a hydrogen atomic nuclear spin method;
an output module configured to: and drawing a magnetic field intensity boundary line based on the magnetic field intensity of all the motion tracks and the magnetic field intensity of all the track change points to obtain the magnetic field intensity of the region to be measured of the nuclear magnetic resonance instrument.
In a third embodiment, the present embodiment further provides an electronic device, which includes a memory, a processor, and computer instructions stored in the memory and executed on the processor, where the computer instructions, when executed by the processor, implement the method in the first embodiment.
In a fourth embodiment, the present embodiment further provides a computer-readable storage medium for storing computer instructions, and the computer instructions, when executed by a processor, implement the method of the first embodiment.
The above description is only a preferred embodiment of the present disclosure and is not intended to limit the present disclosure, and various modifications and changes may be made to the present disclosure by those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present disclosure should be included in the protection scope of the present disclosure.
Claims (8)
1. The nuclear magnetic resonance magnetic field measurement method based on the particle accelerator is characterized by comprising the following steps:
emitting accelerated particles to a region to be measured of a nuclear magnetic resonance instrument by using a particle accelerator; recording the motion track and the track change point of the accelerated particles in the area to be measured;
changing the emission angle of the particle accelerator, and emitting accelerated particles to the region to be measured of the nuclear magnetic resonance instrument again; recording the motion track and the track change point of the accelerated particles in the area to be measured after the emission angle is changed;
repeating the previous step for a set number of times; then, for each motion track, calculating the magnetic field intensity of the current motion track by using a magnetic deflection method; for each track change point, calculating the magnetic field intensity of the current track change point by using a hydrogen atomic nuclear spin method;
and drawing a magnetic field intensity boundary line based on the magnetic field intensity of all the motion tracks and the magnetic field intensity of all the track change points to obtain the magnetic field intensity of the region to be measured of the nuclear magnetic resonance instrument.
2. The method of claim 1, further comprising:
applying reverse magnetic field intensity to a region to be measured of the nuclear magnetic resonance apparatus;
emitting accelerated particles to a region to be measured of a nuclear magnetic resonance instrument by using a particle accelerator; recording the motion track of the accelerated particles in the region to be measured;
judging the sizes of the track deflection angle and a set threshold value, and returning to the step of utilizing the particle accelerator to emit accelerated particles to a region to be measured of the nuclear magnetic resonance spectrometer if the track deflection angle is larger than the set threshold value; if the track deflection angle is smaller than the set threshold value, correcting the size of the reverse magnetic field intensity, and returning to the region to be measured of the nuclear magnetic resonance apparatus to apply the reverse magnetic field intensity; if the track deflection angle is zero, the process is ended and the applied reverse magnetic field strength is output.
3. The method as claimed in claim 1, wherein for each motion trajectory, calculating the magnetic field strength of the current motion trajectory by using a magnetic deflection method; specifically, the method comprises the following steps:
charged particles vertically enter a magnetic field, deflect due to Lorentz force and do uniform-speed circular motion;
according to the track, measuring the time t, the distance s and the circumferential radius r of uniform-speed circular motion, and calculating the corresponding magnetic field by combining the known nuclear-mass ratio q/m:
B＝ms/qrt。
4. the method as claimed in claim 1, wherein for each trajectory change point, the magnetic field strength of the current trajectory change point is calculated by using a hydrogen nuclear spin method, specifically:
placing hydrogen nuclei at the current trajectory change point, and calculating the spin magnetic moment of the hydrogen nuclei:
μ＝epg/2M，
wherein e is the charge of the hydrogen nuclei, M is the mass of the hydrogen nuclei, and g is a constant determined by the nuclear structure;
p is the discrete value of the nuclear angular momentum;
wherein, I is spin quantum number, I is 0, 1/2, 1, 3/2, 2, 5/2, … …, n/2; n is a positive integer; and then the resonance condition can be obtained according to the interaction of the magnetic moment and the external magnetic field, and the magnetic field size of the corresponding point can be calculated.
5. The method as claimed in claim 1, wherein the magnetic field intensity measured by the magnetic deflection method and the hydrogen nuclear spin method is measured for a plurality of times, and the magnetic field intensity at any point is obtained by combining a planar rectangular coordinate system.
6. A nuclear magnetic resonance magnetic field measurement system based on a particle accelerator is characterized by comprising:
a transmit module configured to: emitting accelerated particles to a region to be measured of a nuclear magnetic resonance instrument by using a particle accelerator; recording the motion track and the track change point of the accelerated particles in the area to be measured;
an angle change module configured to: changing the emission angle of the particle accelerator, and emitting accelerated particles to the region to be measured of the nuclear magnetic resonance instrument again; recording the motion track and the track change point of the accelerated particles in the area to be measured after the emission angle is changed;
a magnetic field strength calculation module configured to: repeating the angle changing step for a set number of times; then, for each motion track, calculating the magnetic field intensity of the current motion track by using a magnetic deflection method; for each track change point, calculating the magnetic field intensity of the current track change point by using a hydrogen atomic nuclear spin method;
an output module configured to: and drawing a magnetic field intensity boundary line based on the magnetic field intensity of all the motion tracks and the magnetic field intensity of all the track change points to obtain the magnetic field intensity of the region to be measured of the nuclear magnetic resonance instrument.
7. An electronic device comprising a memory and a processor, and computer instructions stored on the memory and executable on the processor, the computer instructions when executed by the processor performing the method of any of claims 1-5.
8. A computer-readable storage medium storing computer instructions which, when executed by a processor, perform the method of any one of claims 1 to 5.
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