CN111544490A

CN111544490A - Traditional Chinese medicine composition for preventing and treating chilblain

Info

Publication number: CN111544490A
Application number: CN202010631247.9A
Authority: CN
Inventors: 赵德柱; 王凤
Original assignee: Yichun University
Current assignee: Yichun University
Priority date: 2020-07-03
Filing date: 2020-07-03
Publication date: 2020-08-18

Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating chilblain. The composition comprises, by weight, 20-30 parts of selaginella tamariscina, 200 parts of solanum lyratum stem, 10-20 parts of lycopodium clavatum and 15-25 parts of purslane. The invention is a pure Chinese medicinal preparation, and has the effects of warming and activating meridian, dispelling cold and relieving pain; promoting qi and blood circulation, relieving swelling and itching; clearing away heat and toxic material, promoting blood circulation to disperse blood clots, etc. Can effectively improve microcirculation, remove microthrombus, promote blood circulation, repair injured tissues and cure diseases. Also has health promotion effects of relieving fatigue, dispelling cold, promoting metabolism, calming heart, tranquilizing mind, and promoting sleep. The formula has the advantages of easily-accessible raw materials, simple preparation, convenient use, low price, definite curative effect, quick response, difficult relapse, no toxic or side effect and the like, and can effectively prevent and treat chilblain.

Description

Traditional Chinese medicine composition for preventing and treating chilblain

The technical field is as follows:

the invention belongs to the field of medicines, and particularly discloses a traditional Chinese medicine composition for preventing and treating chilblain.

Background art:

chilblain is usually caused by low temperature and dampness in winter, and often occurs in hands, feet, auricles, and nose tip. Mainly related to the repeated exposure of the lesion to low temperature environment and poor protection. It is manifested by itching or swelling pain in local areas, purple-red spots, papules or nodules, which may be accompanied by edema and edema. In the course of disease, the epidermis can be detached, bleeding, erosion or ulcer can appear, and finally paralysis or fibrosis can be formed; chilblain is easy to recur.

The chilblain is a damage caused by low-temperature cold invasion, belongs to non-freezing frostbite and is caused by low-temperature and humid conditions from below 10 ℃ to above the freezing point. It is often seen in winter in areas with low temperature and humidity. It is common to children and women, and is better at the exposed parts of hands, feet, auricles, cheeks, and nose tip. Mainly relates to the repeated and long-term exposure of the lesion part to the low-temperature environment and poor protection. The mechanism of occurrence is not clear, and the blood vessels may be in a contracted or spastic state for a long time due to factors such as low temperature and dampness, blood stasis, and cell metabolic disorder. Then microcirculation changes after rewarming, and continuous dilatation of blood vessels, extravasation of blood cells and body fluid, local blood seepage, extravasated blood, edema and the like occur. Some capillaries and even small arteries and veins are damaged to cause thrombus. In severe cases, blisters and skin necrosis may occur. In addition, vegetative nerve functional disturbance, poor blood circulation at extremities, excessive sweating of hands and feet, lack of exercise, etc. may also be the cause of chilblain. The chilblain is easy to recur and is mainly related to chronic vasculitis of local skin after the chilblain is ill and the resistance of the skin is reduced.

The traditional Chinese medicine considers that the chilblain is local or systemic injury caused by cold evil invasion of a human body. The disease names are found in sui Qi & lttheory of disease origin, cold rotten swelling and sore, and in historical documents, there are the names of cold rotten sore, cold wind and cold crack. The pathogenesis of the disease is that cold invades the skin, congeals blood vessels, loses yang qi in warmth and passes through, and is formed by stagnation of qi and blood.

The clinical manifestations are cold feeling and needle-prick pain at the affected part, numbness and then loss of sensation. After rewarming, burning, swelling, itching or (and) pain appear, and the itching becomes worse after heating. Skin lesions mostly occur in fingers, backs of hands, faces, pinna, toes, edges of feet, heels and the like, and local skin is pale and cool first, and then red, swollen and hard or purplish red plaques appear. In severe cases, blisters, bleeding, erosion or ulceration, infection, necrosis, etc., may occur, even with the formation of scars.

At present, chilblain is mainly prevented, and winter-proof and waterproof clothes should be worn when people go out in winter. In cold environment, cold protection and warm keeping are required, and particularly, the warm and dry keeping of the exposed parts of hands, feet, ears and the like is very important.

Western medicine treatment has two methods of systemic and local application, the systemic treatment is usually oral or intravenous vasodilating medicines, and the local application is based on the principles of detumescence, anti-inflammation and blood circulation promotion. The western medicines for chilblain at present mainly fall into three categories: vasodilating, anticoagulant and anti-inflammatory agents. Such as nifedipine, a calcium antagonist, 0.2% nitroglycerin ointment, anisodamine; heparin sodium cream, mucopolysaccharide polysulfonate cream; ofloxacin, furacilin ointment, etc. In addition, there are physiotherapy such as He-Ne laser and infrared. In a word, the western medicine treatment method is less, is mostly used for symptomatic treatment, and has the defects of slow effect, poor effect, no radical cure, easy relapse, large side effect, high cost and the like.

The traditional Chinese medicine treatment comprises internal treatment and external treatment. The internal treatment mainly treats the disease based on syndrome differentiation by warming and activating cold, and tonifying yang and activating blood as the principles: modified Dang Gui Siji Tang or Gui Zhi Jia Dang Gui Tang for congealing cold with blood stasis; modified Siqijiashen decoction or Shenfu decoction for cold exuberance and yang decline; modified Simiaoyong' an decoction for stasis-resolving and heat-resolving; modified ren Shen Yan Rong Tang or Bazhen Tang combined with Gui Zhi Tang for qi deficiency and blood stasis. The external treatment is performed by various dosage forms of medicines, such as ointment, tincture, medicinal liquor, powder, decoction and the like, and the common medicines comprise chilblain cream with various components, 10% pepper alcohol immersion liquid, red ganoderma wine, ginger and pepper tincture, yang and decongestant cream and the like, but are not enumerated. In addition, acupuncture and moxibustion therapy is also available.

At present, medical science accumulates abundant experience in the aspect of chilblain treatment, and the methods are various and can be called all flowers and all families struggle for singing. The traditional Chinese medicine shows good effect and unique advantages for treating the disease. However, the fish and dragon are mixed, the effect is different, the formula is different, and even in a plurality of formulas, the clinical curative effect cannot be distinguished one by one. The excellent prescription has not been widely accepted and popularized in the industry. The textbook does not recommend an effective medicine, so that the effect of the medicine taken by the patient is not satisfactory. Therefore, an effective drug for treating chilblain is urgently needed to be provided.

For example, Chinese patent publication No. CN103285034A "A medicine for treating chilblain and its preparation method" comprises the following raw materials: iodine: 3-5 parts of potassium iodide: 3-5 parts of glycerol: 8-12 parts of lanolin: 4-6 parts of beeswax: 4-8 parts of vaseline: 50-70 parts of borneol: 1.5-5.5 parts of eugenol: 0.5-1.5 parts of methyl salicylate: 4-6 parts of horn powder or ox horn powder or antler powder with the fineness of less than 150 meshes: 1-3 parts. Also, as shown in the Chinese patent numbers: 200810123744.7, title of the invention: a medicine for treating chilblain; the Chinese patent application numbers are: 201210013689.2, title of the invention: a Chinese medicinal composition for treating chilblain. The invention relates to a Chinese herbal medicine for preventing and treating chilblain.

How to prepare the traditional Chinese medicine composition for preventing and treating chilblain has the advantages of obvious curative effect, convenient use, short treatment course, no side effect and low medical expense after being used.

The invention content is as follows:

the invention aims to provide a traditional Chinese medicine composition for preventing and treating chilblain, which aims to overcome the defects and shortcomings and provide a Chinese herbal medicine for preventing and treating chilblain, mainly comprising selaginella tamariscina, solanum lyratum, lycopodium clavatum, purslane and the like, further enriching the connotation of traditional Chinese medicine, exploring the great treasure house of traditional Chinese medicine, and inheriting and developing the traditional culture of traditional Chinese medicine. The provided effective traditional Chinese medicine formula for treating chilblain has low treatment cost and no side effect.

The invention discloses a traditional Chinese medicine composition for preventing and treating chilblain, which comprises the following components in parts by mass:

20-30 parts of selaginella tamariscina, 100-200 parts of solanum lyratum stem, 10-20 parts of lycopodium clavatum and 15-25 parts of purslane.

The traditional Chinese medicine composition for preventing and treating chilblain preferably comprises, by mass, 30 parts of selaginella tamariscina, 200 parts of solanum lyratum, 15 parts of lycopodium clavatum and 20 parts of purslane.

The invention further comprises the following raw materials, by mass, 20 parts of selaginella tamariscina, 150 parts of solanum lyratum, 10 parts of lycopodium clavatum and 15 parts of purslane.

The traditional Chinese medicine composition for preventing and treating chilblain further comprises 4-6 parts of hibiscus, 6-8 parts of rose flower and 10-14 parts of camphor.

The preparation method is simple, and the medicine can be prepared into powder, plaster or ointment and the like in pharmaceutics. The preparation method is carried out according to the existing production method or carried out in the following method.

The traditional Chinese medicine formula for treating chilblain can be prepared into various dosage forms according to technical means known by technical personnel in the field, such as decoction (lotion), ointment, powder, tincture and the like, and the decoction (lotion) and the ointment are preferred.

The application method comprises decocting the above raw materials with water once a day, and soaking the affected part at night before sleep for 20-30 min each time.

The raw material processing method and the using method of the invention are as follows: preferably, it is treated as follows, also in the prior art,

1. the herba Portulacae is dry, and the length of the herba Portulacae is 3 cm. Putting the raw materials into an enamel basin, and adding a proper amount of water to soak for 1 hour. Boiling with strong fire, decocting with slow fire for 30min, and soaking when the water temperature is reduced to appropriate temperature;

2. if the raw material medicine is calculated according to the weight unit gram, the preferred water adding amount is about 2500ml, and the like according to the proportion, so that the effective concentration of the medicine and the net output of the liquid medicine are ensured. The simple method for judging the concentration of the medicine is to observe the color of the tea approximately similar to that of the concentrated tea by naked eyes, and the clear amount of the liquid medicine is preferably to submerge the ankle joint.

3. The water temperature during the soaking is preferably 40 to 47 ℃, and preferably 45 ℃. It is hot but not hot, to the extent that the foot can tolerate it. The ideal temperature is between "comfortable and tolerable" for heat, and everyone decides on his or her own temperature based on this range.

4. The soaking time is 20-30 minutes, and the preferred soaking time is 20 minutes. The treatment purpose can not be achieved in a short time, and the long-term treatment easily causes the consumption of yang qi and the cold feeling of the body.

5. The use of a wooden basin or wooden barrel bulb is preferred because the wooden barrel can be kept at a constant temperature. The patient has no uncomfortable feeling and adverse reaction during the coating process; the invention has long-term efficacy maintaining performance, less coating times and more convenient and rapid healing of patients. Simple preparation, long shelf life and short treatment time.

The effects of part of raw material medicaments in the invention are as follows:

herba Selaginellae: herba Cynomorii, radix Cynanchi Stauntonii, radix Aconiti Kusnezoffii, herba Rohdeae Japonicae, and herba Senecionis Cannabifolii. Pungent and mild in nature and flavor, non-toxic, entering liver and heart meridians. Has the functions and indications of promoting blood circulation and stimulating the menstrual flow. Can be used for treating amenorrhea and dysmenorrhea. Abdominal mass, lump and mass, traumatic injury. Herba Selaginellae is carbonized to remove blood stasis and stop bleeding. Can be used for treating hematemesis, metrorrhagia, hematochezia, and rectocele. Modern pharmacological research proves that the traditional Chinese medicine composition has the effects of resisting cancer, stopping bleeding, inhibiting bacteria and relieving spasm.

And (3) frosting the eggplant stems: namely eggplant stems, eggplant seedlings and the like. Sweet and pungent in nature and cold in nature. The functions and main indications are dispelling wind and promoting diuresis; clear heat and stop bleeding. Wind-damp-heat arthralgia; beriberi; bloody dysentery; hematochezia; hemorrhoidal bleeding; blood stranguria; pruritus vulvae of women; itch of the skin; chilblain. Modern pharmacological research shows that the traditional Chinese medicine composition has the effects of resisting inflammation, easing pain, resisting oxidation and improving microcirculation.

B, common clubmoss herb: also named as Shisong, Shizicao, Shujincao, etc. Bitter and pungent in flavor, warm in nature, non-toxic, and entering liver, spleen and kidney meridians. Has the functions and main indications of expelling wind and clearing away cold, removing dampness and reducing swelling, relaxing muscles and stimulating blood circulation. Wind-cold-dampness arthralgia, numbness of skin, weakness of limbs, edema and traumatic injury. Modern pharmacological research proves that the traditional Chinese medicine composition has anti-inflammatory, analgesic and antibacterial effects.

Purslane: herba Portulacae, herba Penthori chinensis, and herba WUXINGCAO. It is sour in nature and cold in nature, entering large intestine and liver meridian. Has the functions and main indications of clearing away heat and toxic material, cooling blood and stopping dysentery; to remove dampness and treat stranguria. Dysentery due to major heat toxin; hot spraying; anuria; leucorrhea with reddish discharge; (ii) metrorrhagia and metrostaxis; hemorrhoidal bleeding; sores, ulcers, carbuncles and furuncles; erysipelas; scrofula; tinea pedis; baldness. Modern pharmacological research proves that the traditional Chinese medicine composition has the effects of resisting bacteria, diminishing inflammation, enhancing immunity, resisting aging and the like.

Warm water is used for promoting local blood circulation and improving tissue ischemia and hypoxia according to the theory that the cold condition is hot and the general rule is not painful in the traditional Chinese medicine. The warm stimulation can make people feel comfortable and relaxed. Has effects in relieving fatigue, expelling cold, promoting metabolism, dredging channels and collaterals, regulating qi-flowing, promoting blood circulation, calming heart, tranquilizing mind, and promoting sleep. The invention is prepared from pure Chinese herbal medicine materials, and the research of pathology and toxicology tests and the actual use prove that the medicinal composition product has no toxic or side effect on human bodies and has safety.

Adverse reactions and toxic and side effects were detected 7 days after treatment by monitoring patients for blood pressure, pulse, and clinical symptoms of nausea, vomiting, and vertigo. The normal systolic pressure of human body is set to be between 90-140mmHg, the diastolic pressure is set to be between 60-90mmHg, the normal pulse of human body is 60-100 times/min, the blood pressure and pulse of patient are measured during the treatment period, the recorded blood pressure and pulse are all in the normal range, the phenomenon of exceeding the normal interval does not occur, and the clinical symptoms of nausea, vomit and dizziness do not occur. The result shows that the pharmaceutical composition of the invention has no obvious adverse reaction, and further proves that the pharmaceutical composition has no obvious toxic or side effect on human bodies.

The use method comprises the following steps: one dose is taken every day, and the external washing is carried out by decocting the raw materials with water once a day. Firstly, the frost eggplant rod is cut into a length of 3 cm. Then all the raw materials are put into an enamel basin together, and 2500ml of clean water is added for soaking for 1 hour. Boiling with strong fire, decocting with slow fire for 30min, pouring the medicinal liquid into a wooden barrel, cooling to about 45 deg.C, and soaking the affected part before sleeping late for 20 min each time.

Toxicity test in animals

The method comprises the following steps: 12 healthy adult rabbits with half male and female body weight of 2.2 + -0.1 kg are selected. The hair on both sides of the dorsal spine of the rabbits was shaved by electric hair clippers of an infant 24h before the administration, ranging from 5cm by 10cm and having an area of about 50cm 2. Rabbits were randomly divided into control and experimental groups, 6 each. The control group uses clear water, and the experimental group uses the liquid medicine of the formula. The gauze soaked with clear water and medicinal liquid was covered on the shaved area of the control group and the experimental group, respectively, and fixed with adhesive tape, and repeatedly applied with syringe to ensure the gauze was wet. It is administered once daily for 6 hr for 7 days. The animals are observed for general toxic manifestations, including changes in body weight, skin, hair, eyes and mucous membranes, changes in respiration, circulation, central nervous system, limb activity, etc. The death of the animals and the histopathological changes of the organ being poisoned were observed.

As a result, the control group and the observation group showed no abnormal expression. The skin of the medicine application part has no adverse reaction and no poisoning and death phenomenon. The anatomical viscera tissues after sacrifice are not abnormal, which shows that the medicine has no toxic or side effect on the rabbits.

And (3) clinical observation:

general data

1126 chilblain patients, 641 men and 485 women; age 7-55 years, mean 27 years; the shortest disease course is 2 days, the longest disease course is 5 years, the average disease course is 3 months, and the specific curative effect conditions are shown in tables 1 and 2.

The treatment method comprises the following steps:

the traditional Chinese medicine formula composition is selected, one dose is taken every day, and the traditional Chinese medicine formula composition is decocted with water and washed externally once a day; firstly, the frost eggplant rod is cut into a length of 3 cm. Then all the raw materials are put into an enamel basin together, and 2500ml of clean water is added for soaking for 1 hour. Boiling with strong fire, decocting with slow fire for 30min, pouring the medicinal liquid into a wooden barrel, cooling to about 45 deg.C, and soaking the affected part before sleeping at night for 20-30 min each time. 5 days is a course of treatment, the other components are decocted according to the existing method for use, and the curative effect is generally determined after one course of treatment.

Results

In total 1126 patients, 756 patients are treated by the traditional Chinese medicine composition for preventing and treating chilblain, the traditional Chinese medicine composition is a treatment group, 753 patients are cured and effective, the total effective rate is over 99.7 percent, and the patients have no adverse reaction. The results show that the invention has the advantages of good curative effect, quick response, no toxic or side effect and the like. And 370 cases for the control group.

Clinical diagnosis and observation of curative effect:

(2) in the control group, the concentration of the active ingredients in the active ingredients,

the curative effect result is judged by using the general medicine for treating chilblain sold in the market. And counting the statistical result according to the conventional statistical method.

And (3) analyzing a curative effect result:

and (3) curing: the indexes of skin lesion regression, red swelling, pain and itch disappearance decrease by 7-9 minutes respectively, or the skin recovers to be normal or to be colored; or the total integral of the indexes is 0;

the effect is shown: the indexes of skin lesion fading, red swelling, pain and itch disappearance decrease by 5 to 6 minutes respectively; or eliminating most of the lesions of the skin, and gradually relieving heat itching;

the method has the following advantages: the index of disappearance of skin lesions, red swelling, pain and itch is respectively reduced by 3 to 4 minutes; or the symptoms are improved to different degrees;

and (4) invalidation: the indexes of the subsidence of the skin damage, red swelling, pain and itch are respectively reduced by less than 3 points, or the indexes are not changed, and the skin damage is not changed.

The curative effect is as follows: the treatment group is treated for 5 days as a treatment course on average, the longest treatment course is 20 days, the shortest treatment course is 2 days, the control group is treated for 12 days on average, the longest treatment course is about 50 days, and the shortest treatment course is 4 days.

The indexes of skin damage, red swelling, pain, itch, dysfunction and the like of the treatment group are obviously reduced after treatment, and the difference is very obvious (P is less than 0.01) compared with the first two indexes; the latter index also showed significant differences (P < 0.05) compared with the control group (see Table 1), and the total effective rate of the treatment group was 99.53%. The total effective rate of the control group is 94.3% (see table 2). The two groups of the medicine have significant difference (P is less than 0.01).

TABLE 1 comparison of average scores of indices before and after treatment

Description of the drawings: variability, P < 0.01P < 0.05.

TABLE 2 comparison of the two therapeutic effects (n%)

Description of the drawings: the invention treats patients with good curative effect, and the total effective rate is more than 99%.

Typical cases are as follows:

old women, 47 years old, sanitation workers, chilblain for 5 years, chilblain of different degrees, swelling, bright red or dark red spots or induration, cracking and ulceration of some of the two hands, 2 x 3cm in the largest range. Subjective itching, pain, recurring every year in winter. The medicine can be used for healing after 1 course of treatment, has no adverse reaction, and does not relapse in the next year of follow-up visit.

Pengzhi, female, 21 years old, workers suffered from chilblain for 3 years, had dark red or dark purple plaques with different sizes on the two heels and the outer margin of the feet, and had subjective itching and pain. After the medicine is used for 3 days, the symptoms are obviously relieved, the medicine is healed in 5 days, no adverse reaction is caused, and no relapse is seen in follow-up visits.

Yan when male and 6 years old, students suffer from chilblain for 1 month, and the front and outer margins of feet can see dark red spots of about 1 × 1cm, with distinct pruritus due to heat, especially at night, and pain after scratching. The medicine of the present invention can heal after 3 days without adverse reaction and relapse.

The specific implementation mode is as follows:

the present invention will be described in further detail with reference to examples and typical examples of the present invention, wherein the weight is given in parts by mass (g), and the treatment method is carried out using the above-described method of the present invention.

Example 1

The invention relates to a traditional Chinese medicine composition for preventing and treating chilblain, which comprises the following raw materials of, by weight, 30 g of selaginella tamariscina, 200 g of solanum lyratum, 15 g of lycopodium clavatum and 20 g of purslane.

Example 2:

the invention relates to a traditional Chinese medicine composition for preventing and treating chilblain, which comprises the following raw materials of, by weight, 20 g of selaginella tamariscina, 150 g of solanum lyratum, 10 g of lycopodium clavatum and 15 g of purslane.

Example 3:

the invention relates to a traditional Chinese medicine composition for preventing and treating chilblain, which comprises the following raw material components in parts by mass: 25 g of selaginella tamariscina, 100 g of solanum lyratum, 20 g of lycopodium clavatum and 25 g of purslane.

Example 4 parts by mass

The present example consists of the following mass components:

25 g of selaginella tamariscina, 150 g of solanum lyratum, 10 g of lycopodium clavatum, 20 g of purslane, 5 g of hibiscus, 8 g of rose flower and 12 g of camphor.

Example 5 parts by mass

The present example consists of the following mass components: 25 g of selaginella tamariscina, 100 g of solanum lyratum, 20 g of lycopodium clavatum, 25 g of purslane, 6 g of hibiscus flower, 6 g of rose flower and 14 g of camphor.

Note that: the medicine must be soaked in the part to avoid high temperature. The above-described embodiments of the present invention are provided for illustrative purposes only, and the present invention is not limited thereto. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A traditional Chinese medicine composition for preventing and treating chilblain comprises the following components in parts by mass:

2. The traditional Chinese medicine composition for preventing and treating chilblain is characterized by comprising, by mass, 30 parts of selaginella tamariscina, 200 parts of solanum lyratum, 15 parts of lycopodium clavatum and 20 parts of purslane.

3. The traditional Chinese medicine composition for preventing and treating chilblain is characterized by comprising, by mass, 20 parts of selaginella tamariscina, 150 parts of solanum lyratum thunb, 10 parts of lycopodium clavatum and 15 parts of purslane.

4. The traditional Chinese medicine composition for preventing and treating chilblain as claimed in claim 1, wherein the composition further comprises 4-6 parts of hibiscus, 6-8 parts of rosebush and 10-14 parts of camphor.