CN111544465B - Traditional Chinese medicine composition for secondary prevention after PCI (peripheral component interconnect) operation of acute coronary syndrome - Google Patents

Abstract

The invention relates to a traditional Chinese medicine composition for secondary prevention after PCI (peripheral component interconnect) operation of acute coronary syndrome, which is prepared from the following raw material medicines in parts by weight: 10 parts of herba epimedii, 8 parts of radix pseudostellariae, 1.3 parts of leech, 10 parts of salvia miltiorrhiza and 4 parts of honeysuckle. The invention also comprises the application of the traditional Chinese medicine composition in preparing the medicine for the secondary prevention after the PCI operation of the acute coronary syndrome. In the prescription, the epimedium is used as a monarch drug for warming and nourishing the innate kidney essence; radix pseudostellariae tonifies heart qi, and takes the effect of reinforcing the root cause of a disease by a monarch drug as a ministerial drug; leech and salvia miltiorrhiza phlegm-reducing stasis-removing and heart-meridian-dredging, honeysuckle flower is used as an adjuvant drug for clearing heat and toxic materials, the whole formula treats heart and kidney simultaneously, mainly treats tonifying, takes tonifying as dredging, and exerts both the tonifying and the dredging, the tonifying is not obstructed, the dredging is not damaged, and the effects of warming kidney yang, benefiting heart qi, eliminating phlegm and blood stasis and dredging heart-meridian are achieved. The experimental result shows that the prescription is used for the patients with the diseases, has good curative effect, no toxic or side effect and wide application prospect.

Description

Traditional Chinese medicine composition for secondary prevention after PCI (peripheral component interconnect) operation of acute coronary syndrome

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for secondary prevention after PCI (peripheral component interconnect) operation of acute coronary syndrome.

Background

Coronary atherosclerotic heart disease, abbreviated Coronary Heart Disease (CHD), is the most common cardiovascular disease and one of the most common diseases leading to death of patients. CHD is divided into two major categories, namely Acute Coronary Syndrome (ACS) and Chronic Ischemic Syndrome (CIS), wherein ACS is the most dangerous type of CHD, frequently accompanies various cardiovascular adverse events (MACE), has poor prognosis and brings heavy burden to families and society of patients. Therefore, how to reduce the incidence, disability rate and fatality rate of ACS is always the focus of attention of people and clinicians in all communities.

ACS is a group of clinical syndromes which are formed into pathological bases by secondary fresh thrombus formed by rupture or erosion of unstable atherosclerotic plaques in coronary arteries, so that acute ischemia of heart is caused, and serious consequences such as myocardial necrosis and sudden cardiac death are caused, and the clinical syndromes have the characteristics of acute morbidity, rapid development, high disability rate and high mortality rate. At present, Percutaneous Coronary Intervention (PCI) becomes one of the most effective means for treating ACS, and has the advantages of quickly relieving angina, increasing coronary blood flow, controlling further deterioration of diseases, obviously improving the life quality of patients, improving the recent prognosis of high-risk patients and the like. However, PCI is not always easy, and 30% to 50% of restenosis occurs in stents when drugs for resisting platelet aggregation, resisting coagulation, reducing blood fat and the like are used and the drugs are continuously updated and replaced according to strict medical advice. Even with Bare Metal Stents (BMS) and drug-coated stents (DES) in clinical use, 10% -30% of unavoidable BMS restenosis, less than 10% DES restenosis and Late Stent Thrombosis (LST) still occur. Restenosis and LST in the stent are important restriction factors of clinical effects after PCI, which can cause ACS patients to reappear symptoms of chest pain, chest distress, palpitation, suffocation, hypodynamia, dizziness and the like with different degrees, and main MACE including angina, acute myocardial infarction, even sudden cardiac death and the like occurs. ACS has the characteristics of chronic mobility and high recurrence, so the research and development of the secondary prevention drug after PCI operation of ACS is very necessary, restenosis and LST can be prevented, and the treatment benefit of patients after PCI operation is maximized.

There is no concept of "restenosis" in classical literature of traditional Chinese medicine, which is a new problem proposed by the development of medical practice. According to its pathogenesis and clinical manifestations, restenosis after PCI operation is equivalent to the categories of "chest impediment", "cardiodynia", "syncope cardiodynia" in traditional Chinese medicine.

The PCI postoperative state of ACS is considered to be the syndrome of deficiency of the origin and marked excess, marked excess is the mutual combination of phlegm and stasis, and the obstruction of heart collaterals is caused, but we pay more attention to the deficiency of the origin, the deficiency is considered to be the serious symptom of kidney deficiency, and the PCI postoperative state is the disease of which the disease is expressed in heart and pathogenesis and is derived from kidney. The traditional Chinese medicine theory considers that the kidney is the congenital base and mainly stores congenital essence and essence of five zang organs and six fu organs. The book of Yi guan & Xuan Yuan Fu Lun (treatise on the skin of Yao Yuan): the true five zang organs, but the kidneys are the roots. Kidney essence is the basic material of human life. The kidney essence transforms yang to generate qi and yang, and promotes the function of viscera by warming and qi transformation, which is the source of qi transformation and the root of yang; kidneys essence and yin can generate yin blood, essence and body fluid to moisten the body and viscera, which are the basis of body and yin. Under normal conditions, the coordination of yin and yang in the kidney, the combination of body and body, the abundance of yin essence and the activity of warming, promote the exuberance and smoothness of qi and blood, and the normal ascending and descending of qi movement and qi transformation. However, as the human body grows, is strong and old, essential qi is inevitably consumed, and the self-aging of the human body, namely the physiological kidney deficiency, appears. For example, cloud in Su Wen, Yin Yang congress theory of correspondence: "forty years and sixty years of the half of the past … … years of yin qi, yin fistula and qi decline", the literature of Su Wen and ancient Tianzhen Lun: the theory that the deficiency of kidney essence and the aging are closely related is explained by the fact that the kidney essence is weakened, the male has the five eight organs, the kidney is declined, the male has the seven eight organs … …, the female has the dry and withered teeth, the male has the … … day-old kidney-essence, the kidney is weakened, and the male has the extreme physique. The latter causes such as six excesses, seven emotions, over-tired diet, seasonal epidemic toxin, etc. can also directly damage the kidney or affect the kidney through other organs, thus aggravating the loss of kidney essence. "longevity life preservation and benefit": the birth of the man is mainly kidney, and the disease of man is mostly caused by kidney deficiency. The ACS patients are more middle-aged and old, and when the kidney essence is abundant, the heart yang is excited and moves forcefully, and the blood can smoothly run; if it is deficient in kidney qi, failing to transpire and warm heart yang, it will lead to heart yang deficiency, blood vessels failing to warm and slow blood circulation, and obstruction of chest yang, manifested as obstruction of qi in the chest; if it fails to nourish heart yin due to kidney yin deficiency, it will cause loss of moistening of the vessels, stagnation of blood flow, obstruction of heart vessels, and chest impediment. Zhang Jingyue proposes: the heart-qi usually refers to the kidney, so there is no anxiety in the upper part, and there is no sperm in the heart-qi. The kidney essence deficiency of ACS patients already exists, and the inevitable damage repair process caused by PCI treatment, the generation and development of ISNA and the use of large dose of anticoagulant drugs as the acquired causes all aggravate the consumption of vital qi and further aggravate the consumption of kidney essence. Therefore, the PCI postoperative state of ACS is considered to be expressed in the heart and originated from the kidney, namely, the kidney deficiency is the root cause of the disease. Kidneys are closely related to the regulation of body fluids, and yin and yang of lung and spleen are both derived from kidney yin and kidney yang, so if kidney qi is insufficient and qi fails to be right, body fluids will be coagulated into phlegm. So Zhang Jingyue says: the transformation of phlegm is not in the spleen, but in the kidney. Cloud of Yi guan (medicine guan): for phlegm, water also originates from the kidneys. On the other hand, kidney qi is the prime motive force of life and mainly plays a role in the circulation of qi and blood of the whole body, and if kidney qi is deficient, the original qi is deficient, and qi of five zang organs is transformed into poor source, qi deficiency fails to circulate blood to cause stasis, as so-called in Yi Lin correction: "original qi is deficient and must not reach the blood vessel, and the blood vessel is not gaseous and must stay to cause stasis. The kidney deficiency is the source of the formation of phlegm and stasis, and the formation of pathological products such AS phlegm and stasis is an important component of an AS generation mechanism, namely, the infiltration of fat on the arterial wall is phlegm stagnation channels, and the accumulation of blood platelets on the intima of the artery and the formation of thrombus are the expression of blood stasis blocking collaterals. Namely: ACS, like other coronary heart diseases, has the marked excess of phlegm-blood stasis and obstruction of heart vessels. The treatment of ACS by PCI is only a temporary local treatment from the traditional Chinese medical theory, and cannot radically change the pathogenesis characteristics of the ACS of deficiency in origin, excess in excess; moreover, PCI causes direct injury to the intima of blood vessels, causes disorder of local qi and blood circulation, can cause aggravation of retention of phlegm stasis, further aggravates consumption of healthy qi due to exogenous trauma and use of a large amount of anticoagulant drugs, and further causes ISNA to cause ISR and LST in vicious circle. Therefore, the pathogenesis of ACS after PCI operation is characterized by deficiency of origin and excess of origin, deficiency of the kidney as origin, phlegm and blood stasis as targets, accumulation of phlegm and blood stasis and obstruction of heart vessels. In summary, we believe that the pathogenesis of ACS after PCI surgery is characterized by: it is manifested in the heart, rooted in the kidney, deficient in the kidney, marked by phlegm and blood stasis, combined phlegm and blood stasis, and obstructed collaterals of the heart. The treatment should regulate qi, blood, yin and yang as a whole, treat both heart and kidney, make yin balance and yang balance, and regulate qi and blood, so as to make up the deficiency of PCI local treatment, resist the occurrence and development of ISNA, and prevent ISR and LST from being in the first place. For example, in the section of Qing Dynasty famous medical records essence Wang Jiu Feng: "Xianling leech pellet" is prepared to have the efficacies of warming kidney yang, benefiting heart qi, eliminating phlegm and stasis, and dredging heart collaterals, because the upper part of the treatment must ask the lower part of the treatment, the seedling-nourishing person must irrigate the root of the treatment, heart is the pathogenic target, kidney is the disease-affected root, and heart is the special treatment for kidney without pinching heart. The prescription is applied to a patient with ACS after PCI operation in the earlier period based on western medicine treatment, so that the incidence rate of angina and the hospitalization rate of the patient are obviously reduced, the electrocardiogram is improved, and the left ventricular ejection fraction is improved. Modern researches also show that the kidney-tonifying and blood-activating medicine can reduce blood fat, reduce blood viscosity, enhance myocardial contractility, dilate coronary artery, increase coronary artery blood flow, reduce myocardial oxygen consumption, improve blood rheological property, resist platelet aggregation, resist coagulation, reduce coronary artery resistance and improve myocardial blood supply; can also obviously lower ET level and up-regulate NO level, can improve vascular endothelial function to a certain extent, and delay the progress of AS. Therefore, the granules are effective medicaments for secondary prevention after PCI (peripheral component interconnect) operation of the acute coronary syndrome.

The traditional Chinese medicine composition for the secondary prevention after the PCI operation of the acute coronary syndrome is not reported at present.

Disclosure of Invention

The first purpose of the invention is to provide a traditional Chinese medicine composition for secondary prevention after PCI surgery of acute coronary syndrome.

The second purpose of the invention is to provide the application of the traditional Chinese medicine composition.

The third purpose of the invention is to provide a secondary prevention drug after PCI operation of acute coronary syndrome.

A fourth object of the present invention is to provide a process for the preparation of the medicament as described above.

In order to achieve the first purpose, the invention adopts the technical scheme that:

a traditional Chinese medicine composition for secondary prevention after PCI surgery of acute coronary syndrome is prepared from the following raw material medicines in parts by weight: 5-15 parts of herba epimedii, 3-13 parts of radix pseudostellariae, 0.8-1.8 parts of leech, 5-15 parts of salvia miltiorrhiza and 2-6 parts of honeysuckle.

As a preferred embodiment of the invention, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 8-12 parts of herba epimedii, 6-10 parts of radix pseudostellariae, 1.1-1.5 parts of leech, 8-12 parts of salvia miltiorrhiza and 3-5 parts of honeysuckle.

As a preferred embodiment of the invention, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 10 parts of herba epimedii, 8 parts of radix pseudostellariae, 1.3 parts of leech, 10 parts of salvia miltiorrhiza and 4 parts of honeysuckle.

Preferably, the clinically acceptable pharmaceutical preparation is prepared according to a conventional preparation method of the traditional Chinese medicine.

Preferably, the pharmaceutical preparation is granules, powder, capsules, tablets, mixture or oral liquid.

As a preferred embodiment of the invention, the symptoms of the acute coronary syndrome are kidney-yang deficiency and phlegm stagnation.

In order to achieve the second object, the invention adopts the technical scheme that:

the application of the traditional Chinese medicine composition in preparing the medicine for the secondary prevention after PCI (peripheral component interconnect) operation of the acute coronary syndrome.

As a preferred embodiment of the invention, the symptoms of the acute coronary syndrome are kidney-yang deficiency and phlegm stagnation.

In order to achieve the third object, the invention adopts the technical scheme that:

a secondary prevention medicine used after PCI surgery of acute coronary syndrome is prepared from the traditional Chinese medicine composition.

As a preferred embodiment of the present invention, the preparation method of the medicine is as follows:

(1) taking raw material medicines: decocting herba Epimedii, radix Pseudostellariae, and Hirudo in water for 0.5-1.5 hr;

(2) adding radix Salviae Miltiorrhizae and flos Lonicerae, and decocting for 30-40 min;

(3) and (4) leaching out juice, precipitating and taking clear liquid.

In order to achieve the fourth object, the invention adopts the technical scheme that:

a preparation method of a secondary prevention medicine used after PCI surgery of acute coronary syndrome comprises the following steps:

(1) taking raw material medicines: decocting herba Epimedii, radix Pseudostellariae, and Hirudo in water for 0.5-1.5 hr;

(2) adding radix Salviae Miltiorrhizae and flos Lonicerae, and decocting for 30-40 min;

(3) and (4) leaching out juice, precipitating and taking clear liquid.

Preferably, the present recipe is mainly used for treating: warming kidney yang, benefiting heart qi, eliminating phlegm and blood stasis, dredging heart collaterals, with symptoms of chest distress and chest pain, asthenia, soreness of waist and backache, weakness of both lower limbs, nocturia for more than 2 times, dark or gloomy complexion, pale and dark tongue, or ecchymosis and petechia, thin and greasy or thick greasy fur, deep and thready pulse, and the like belonging to kidney yang deficiency, phlegm and blood stasis stagnation syndrome; the symptoms caused by the PCI operation of the acute coronary syndrome.

The formula is as follows: according to the onset characteristics and clinical manifestations of this disease, it is equivalent to the categories of "chest impediment", "cardiodynia" and "jueyxin cardiodynia" in traditional Chinese medicine. Through many years of intensive studies, the disease is considered to be a syndrome of deficiency and excess of origin, the excess is marked as 'phlegm' and 'stasis' which are mutually combined and obstruct heart collaterals, but the deficiency is considered to be serious by paying more attention to the deficiency, the deficiency is considered to be serious by the deficiency of the kidney, the PCI postoperative state is a disease which is shown in heart and pathogenesis root and is derived from kidney, the 'xianling leech pill granules' are prepared, and the ingredients in the formula are 5 medicines of epimedium, radix pseudostellariae, leech, salvia miltiorrhiza and honeysuckle. The epimedium is used as a monarch drug for warming and nourishing the innate kidney essence; radix pseudostellariae tonifies heart qi, and takes the effect of reinforcing the root cause of a disease by a monarch drug as a ministerial drug; leech and salvia miltiorrhiza phlegm-reducing stasis-removing and heart-meridian-dredging, honeysuckle flower is used as an adjuvant drug for clearing heat and toxic materials, the whole formula treats heart and kidney simultaneously, mainly treats tonifying, takes tonifying as dredging, and exerts both the tonifying and the dredging, the tonifying is not obstructed, the dredging is not damaged, and the effects of warming kidney yang, benefiting heart qi, eliminating phlegm and blood stasis and dredging heart-meridian are achieved.

As a preferred embodiment of the invention, the granules for secondary prevention after PCI surgery of acute coronary syndrome are prepared from 10g of epimedium, 8g of radix pseudostellariae, 1.3g of leech, 10g of salvia miltiorrhiza and 4g of honeysuckle. Preferably, the usage amount: orally taken one bag at a time and three times a day.

The invention has the advantages that:

1. the xianling leech pill granules are a novel composition which is prepared by taking epimedium, radix pseudostellariae, leech, salvia miltiorrhiza and honeysuckle as prescriptions and is guided by the basic theory of traditional Chinese medicine and combined with the modern research results, and the new composition has the symptoms of chest distress, chest pain, weakness, waist soreness and backache, weakness of both lower limbs, nocturia for more than 2 times, dark or gloomy complexion, pale and dark tongue quality or ecchymosis and petechia, thin and greasy tongue coating, deep and fine pulse and the like, and is used for treating the secondary prevention after the PCI surgery of the acute coronary syndrome.

The functional indications are as follows: warming kidney yang, benefiting heart qi, eliminating phlegm and blood stasis, and dredging heart meridian. Can be used for the secondary prevention after PCI operation. Modern pharmacology finds that the kidney-tonifying and blood-activating medicine can reduce blood fat, reduce blood viscosity, enhance myocardial contractility, dilate coronary artery, increase coronary artery blood flow, reduce myocardial oxygen consumption, improve blood rheological property, resist platelet aggregation, resist coagulation, reduce coronary artery resistance and improve myocardial blood supply; can also obviously lower ET level and up-regulate NO level, can improve the vascular endothelial function to a certain extent, and delay the development of atherosclerosis, thereby making up the adverse effect of singly using western medicines for treatment.

2. The formula is applied to patients after PCI (peripheral component interconnect) surgery of acute coronary syndrome in the early stage on the basis of western medicine treatment, so that the incidence rate of angina and the hospitalization rate of the patients are obviously reduced, the electrocardiogram is improved, and the left ventricular ejection fraction is improved. The routine examination of blood, urine and feces, liver function, heart function, kidney function, blood sugar and the like is carried out on the patients receiving the treatment, and no toxic or side effect is found.

The traditional Chinese medicine composition is common clinical medicines, has no toxicity, and can verify the safety and effectiveness of the medicine through pharmacodynamic study of a single medicine.

The traditional Chinese medicine composition is developed according to the traditional Chinese medicine pathogenesis characteristics after the acute coronary syndrome PCI operation, pharmacodynamic research and clinical observation further prove the effectiveness and action mechanism of the composition, has the integral action characteristics of warming kidney yang, benefiting heart qi, removing phlegm stasis, dredging heart collaterals and the like, is an effective composition for treating the secondary prevention after the acute coronary syndrome PCI operation, and is further popularized and applied.

3. The invention optimizes the raw materials and the proportion thereof, accords with the compatibility principle of monarch, minister, assistant and guide, can be effectively used for the secondary prevention after the PCI operation of the acute coronary syndrome, can be well applied to clinic and has good application prospect.

Detailed Description

The invention will be further illustrated with reference to specific embodiments. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. Furthermore, it should be understood that various changes and modifications can be made by those skilled in the art after reading the disclosure of the present invention, and equivalents fall within the scope of the appended claims.

EXAMPLE 1 Chinese medicinal composition 1

The raw material medicaments are taken according to the following weight portion: 5 parts of herba epimedii, 3 parts of radix pseudostellariae, 0.8 part of leech, 5 parts of salvia miltiorrhiza and 2 parts of honeysuckle.

EXAMPLE 2 Chinese medicinal composition (II)

The raw material medicaments are taken according to the following weight portion: 15 parts of herba epimedii, 13 parts of radix pseudostellariae, 1.8 parts of leech, 15 parts of salvia miltiorrhiza and 6 parts of honeysuckle.

EXAMPLE 3 Chinese medicinal composition (III)

The raw material medicaments are taken according to the following weight portion: 5 parts of herba epimedii, 13 parts of radix pseudostellariae, 0.8 part of leech, 15 parts of salvia miltiorrhiza and 2 parts of honeysuckle.

EXAMPLE 4 Chinese medicinal composition (IV)

The raw material medicaments are taken according to the following weight portion: 15 parts of herba epimedii, 3 parts of radix pseudostellariae, 1.8 parts of leech, 5 parts of salvia miltiorrhiza and 6 parts of honeysuckle.

EXAMPLE 5 Chinese medicinal composition (V)

The raw material medicaments are taken according to the following weight portion: 8 parts of epimedium, 6 parts of radix pseudostellariae, 1.1 parts of leech, 8 parts of salvia miltiorrhiza and 3 parts of honeysuckle.

EXAMPLE 6 Chinese medicinal composition (VI)

The raw material medicaments are taken according to the following weight portion: 12 parts of epimedium, 10 parts of radix pseudostellariae, 1.5 parts of leech, 12 parts of salvia miltiorrhiza and 5 parts of honeysuckle.

EXAMPLE 7 Chinese medicinal composition (seven)

The raw material medicaments are taken according to the following weight portion: 8 parts of epimedium, 10 parts of radix pseudostellariae, 1.1 parts of leech, 12 parts of salvia miltiorrhiza and 3 parts of honeysuckle.

EXAMPLE 8 Chinese medicinal composition (eight)

The raw material medicaments are taken according to the following weight portion: 12 parts of epimedium, 6 parts of radix pseudostellariae, 1.5 parts of leech, 8 parts of salvia miltiorrhiza and 5 parts of honeysuckle.

EXAMPLE 9 Chinese medicinal composition (nine)

The raw material medicaments are taken according to the following weight portion: 10 parts of herba epimedii, 8 parts of radix pseudostellariae, 1.3 parts of leech, 10 parts of salvia miltiorrhiza and 4 parts of honeysuckle.

Example 10 granules

The preparation method comprises the following steps:

the raw materials are taken according to the weight parts of the embodiments 1-9 respectively: adding 500 ml of water into the herba epimedii, the radix pseudostellariae and the leech, boiling with strong fire, and decocting with small fire for 1 hour; adding Saviae Miltiorrhizae radix and flos Lonicerae, boiling with strong fire, and decocting with slow fire for 30 min. Filtering, concentrating the filtrate, and cooling to room temperature; concentrating the supernatant, adding water, stirring, standing, and concentrating the supernatant into fluid extract. Taking the clear paste, and preparing into granules.

EXAMPLE 11 preparation of tablets/capsules

The preparation method comprises the following steps:

the raw materials are taken according to the weight parts of the embodiments 1-9 respectively: adding 500 ml of water into the herba epimedii, the radix pseudostellariae and the leech, boiling with strong fire, and decocting with small fire for 1 hour; adding Saviae Miltiorrhizae radix and flos Lonicerae, boiling with strong fire, and decocting with slow fire for 30 min. Filtering, concentrating the filtrate, and cooling to room temperature; taking supernatant, and concentrating to obtain thick extract; adding pharmaceutical adjuvants, vacuum drying, pulverizing, granulating, and making into tablet or capsule.

EXAMPLE 12 preparation of decoction

The preparation method comprises the following steps:

the raw materials are taken according to the weight parts of the embodiments 1-9 respectively: decocting herba Epimedii, radix Pseudostellariae, Hirudo, Saviae Miltiorrhizae radix, and flos Lonicerae with water according to conventional method. The Chinese medicinal materials are taken according to the weight part ratio, and are decocted into decoction by adding water.

EXAMPLE 13 clinical trial

1 data of

36 patients after PCI surgery of kidney-yang deficiency and phlegm-stasis arthralgia type acute coronary syndrome who are diagnosed in the Shanghai city Hospital clinic in the period of 1-6 months in 2018 are collected.

2 method

2.1 methods of treatment

The 36 patients were treated with the group of 9 patients on the basis of western medicine treatment of the prior art.

2.2 Observation index

Angina pectoris status, cardiac echocardiogram index and plasma N-terminal pro-brain natriuretic peptide (NT-proBNP), C-reactive protein (CRP) level in the inflammatory response to myocardial injury were compared before and after treatment in 36 patients.

3 results

The results show that: the angina pectoris remission rate is 96.1%; the determination of the heart work index shows that: left Ventricular Ejection Fraction (LVEF) earlier (P <0.05), Stroke Volume (SV) earlier (P <0.05), Cardiac Index (CI) earlier (P < 0.05); the levels of NT-proBNP and CRP are obviously reduced compared with those before treatment. The routine examination of blood, urine and feces, liver function, heart function, kidney function, blood sugar and the like is carried out on the patients receiving the treatment, and no toxic or side effect is found.

4 conclusion

The composition is developed according to the traditional Chinese medicine pathogenesis characteristics after the acute coronary syndrome PCI operation, and pharmacodynamic research and clinical observation further prove the effectiveness and action mechanism of the composition, has the integral action characteristics of warming kidney yang, benefiting heart qi, removing phlegm stasis, dredging heart collaterals and the like, is an effective composition for treating the secondary prevention after the acute coronary syndrome PCI operation, and is worthy of further popularization and application.

The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and additions can be made without departing from the principle of the present invention, and these should also be considered as the protection scope of the present invention.

Claims (7)

1. A traditional Chinese medicine composition for secondary prevention after PCI (peripheral component interconnect) operation of kidney-yang deficiency and phlegm-stasis arthralgia type acute coronary syndrome is characterized by being prepared from the following raw material medicines in parts by weight: 10 parts of herba epimedii, 8 parts of radix pseudostellariae, 1.3 parts of leech, 10 parts of salvia miltiorrhiza and 4 parts of honeysuckle.

2. The traditional Chinese medicine composition of claim 1, which is prepared into a clinically acceptable pharmaceutical preparation according to a conventional traditional Chinese medicine preparation method.

3. The composition of claim 2, wherein the pharmaceutical formulation is a granule, powder, capsule, tablet or mixture.

4. The use of the Chinese medicinal composition of claim 1 in the preparation of a medicament for secondary prevention after PCI surgery of acute coronary syndrome due to kidney yang deficiency and phlegm stagnation and obstruction.

5. A medicine for secondary prevention after PCI surgery of kidney-yang deficiency and phlegm-stasis arthralgia type, which is characterized in that the medicine is prepared from the traditional Chinese medicine composition of claim 1.

6. The medicine for secondary prevention after PCI surgery of syndrome of kidney-yang deficiency and phlegm-stasis obstruction according to claim 5, wherein the preparation method of the medicine is as follows:

(1) taking raw material medicines: decocting herba Epimedii, radix Pseudostellariae, and Hirudo in water for 0.5-1.5 hr;

(2) adding radix Salviae Miltiorrhizae and flos Lonicerae, and decocting for 30-40 min;

(3) and (4) leaching out juice, precipitating and taking clear liquid.

7. The method of preparing the medicament of claim 5, comprising the steps of:

(1) taking raw material medicines: decocting herba Epimedii, radix Pseudostellariae, and Hirudo in water for 0.5-1.5 hr;

(2) adding radix Salviae Miltiorrhizae and flos Lonicerae, and decocting for 30-40 min;

(3) and (4) leaching out juice, precipitating and taking clear liquid.