CN111529631B - Traditional Chinese medicine composition for treating cholecystitis - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating cholecystitis, which comprises the following raw materials in parts by weight: 30-50 parts of bidens alba, 5-10 parts of felwort, 10-15 parts of oldenlandia diffusa, 5-10 parts of verbena, 10-15 parts of dandelion, 10-15 parts of black nightshade, 10-15 parts of plantain, 10-15 parts of longtube ground ivy, 10-15 parts of houttuynia cordata, 10-15 parts of mint and 10-15 parts of lalang grass rhizome. The traditional Chinese medicine composition has a very obvious effect of treating cholecystitis, the effective rate is up to 100%, the effects of both principal and secondary aspects are achieved, and the traditional Chinese medicine composition is safe to eat and free of toxic and side effects.

Description

Traditional Chinese medicine composition for treating cholecystitis

Technical Field

The invention relates to a traditional Chinese medicine composition for treating cholecystitis, belonging to the technical field of traditional Chinese medicine compositions.

Background

Acute biliary tract infection is a disease caused by bacterial infection of biliary tract system, mainly comprises acute cholecystitis and acute cholangitis, and is commonly existed with cholelithiasis and causes each other. Acute biliary tract infection is one of the common causes of acute abdominal diseases, is a common, multiple and refractory disease in surgery, and can be complicated by gallbladder perforation, liver abscess, infectious shock, even death and the like in severe infection. With the improvement of living standard and the increase of working pressure, the incidence rate of cholecystitis is on the rise, and the cholecystitis is a common disease and frequently encountered disease in outpatient cases.

According to the traditional Chinese medicine, acute cholecystitis and acute attack of cholecystitis can be attributed to hypochondriac pain in the traditional Chinese medicine, and although the traditional Chinese medicine has no name of cholecystitis, the traditional Chinese medicine has a relevant discussion in the book of the Canitis. The book of Lingshu, five pathogens (Lingshu, Wu Xian) is characterized by: when the pathogenic factors are in the liver, there is pain in the hypochondrium. "Su Wen & Miao Ri Lun" (Su Wen & Mi Lang Lun of Miao): pathogenic qi can invade the collaterals of foot shaoyang causing hypochondriac pain. The book Ling Shu & Ben Zang is said to be the case of gallbladder distention and fullness in the hypochondrium leading to pain in the lower abdomen. According to clinical manifestations of acute cholecystitis with pain in right upper abdomen as the main cause, the traditional Chinese medicine is named as hypochondriac pain. Exogenous damp-heat toxin, damp-heat entering the interior from the exterior, accumulating in the middle energizer, causing dysfunction of liver and gallbladder in smoothing flow and obstruction of fu-organ qi; or excessive toxic heat accumulating in the gallbladder to cause blood decay and pus accumulation in the gallbladder, manifested as hypochondriac pain; or hypochondriac pain due to retention of damp-heat in the interior, failure of liver and gallbladder to dredge, bile stagnation, and obstructed discharge, resulting in stone formation, obstruction of qi flow in the gallbladder, and pain due to obstruction of the gallbladder.

Acute cholecystitis and cholecystitis are clinically and mainly manifested by pain in the right upper abdomen, and Zhuang nationality medicine is classified as ' Bangbi ' because the body's vital qi is deficient, the body is infected with damp-heat toxin or the body is endogenous due to over-urgent emotion and overeating, which affects the normal operation of ' three ways ' (valley way, water way and air way) ' two ways ' (dragon way and fire way), the passage is blocked, the liver and gallbladder are disordered in dredging, the qi and blood flow is disturbed, and the pathological manifestations of ' obstruction and pain ' appear.

At present, the clinical treatment mainly adopts antibacterial, analgesic, surgical treatment and the taking of cholagogic drugs, such as magnesium sulfate oral drugs, dehydrocholic acid drugs and the like, and the western medicine treatment method has quick effect, but treats the symptoms and the root causes, is easy to relapse, and has higher treatment cost and adverse reaction incidence. Other traditional Chinese medicine treatment means have the defects of slow effect, insufficient curative effect and the like in different degrees.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition for treating cholecystitis, which comprises the following raw materials in parts by weight: 30-50 parts of bidens alba, 5-10 parts of felwort, 10-15 parts of oldenlandia diffusa, 5-10 parts of verbena, 10-15 parts of dandelion, 10-15 parts of black nightshade, 10-15 parts of plantain, 10-15 parts of longtube ground ivy, 10-15 parts of houttuynia cordata, 10-15 parts of mint and 10-15 parts of lalang grass rhizome.

The application of the traditional Chinese medicine composition for treating cholecystitis in preparation of a medicine for treating cholecystitis can prepare the traditional Chinese medicine composition and other acceptable auxiliary materials for a human body into granules, pills, oral liquid and the like.

Bidens alba: sweet in taste, slightly bitter and neutral in nature. Has effects of clearing away heat and toxic materials, promoting diuresis, and eliminating jaundice. It is mainly used for treating common cold, fever, wind-damp arthralgia, jaundice due to damp-heat, carbuncle, swelling, sore and furuncle.

Gentian: bitter taste and cold nature. It enters liver and gallbladder meridians. Has effects of clearing heat, eliminating dampness, and purging liver and gallbladder fire. Can be used for treating jaundice due to damp-heat pathogen, pudendal swelling, pudendal pruritus, leukorrhagia, eczema, pruritus, liver fire with conjunctival congestion, tinnitus, deafness, hypochondriac pain, bitter taste in mouth, middle-jiao strengthening, and convulsion.

Herba Hedyotidis Diffusae: bitter and sweet in taste and cold in nature. It enters heart, liver and spleen meridians. Has effects of clearing away heat and toxic materials, resolving carbuncle, resolving hard mass, inducing diuresis, and relieving swelling. Can be used for treating sore throat, lung heat cough and asthma, stranguria with heat, jaundice due to damp-heat pathogen, venomous snake bite, sore, swelling, heat, and carbuncle.

Verbena: bitter taste and cool nature. It enters liver and spleen meridians. Has effects in cooling blood, removing blood stasis, removing toxic substances, promoting diuresis, eliminating jaundice, and preventing malaria. Can be used for treating abdominal mass, dysmenorrhea, amenorrhea, sore throat, carbuncle, edema, jaundice, and malaria.

Dandelion: bitter and sweet in taste and cold in nature. It enters liver and stomach meridians. Has effects of clearing away heat and toxic materials, relieving swelling, dispersing pathogen accumulation, inducing diuresis, and treating stranguria. Can be used for treating furuncle, pyogenic infection, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, pulmonary abscess, intestinal abscess, jaundice due to damp-heat pathogen, and stranguria with damp-heat pathogen.

Black nightshade: bitter taste, cold nature and slight toxicity. Has effects of clearing away heat and toxic materials, promoting blood circulation, and relieving swelling. Can be used for treating furuncle, carbuncle, erysipelas, traumatic injury, sprain, chronic cough, asthma with phlegm, edema, and cancer.

Plantain herb: sweet in flavor and cold in nature. It enters liver, kidney, lung and small intestine meridians. Has effects of clearing heat, promoting diuresis, treating stranguria, eliminating phlegm, cooling blood, and removing toxic substance. Can be used for treating pyretic stranguria, edema, oliguria, summer-heat dampness, diarrhea, phlegm heat, cough, hematemesis, epistaxis, carbuncle, swelling, and sore.

Herba Glechomae: pungent and slightly bitter in flavor and slightly cold in nature. It enters liver, kidney and bladder meridians. Has effects of promoting diuresis, treating stranguria, clearing away heat and toxic materials, removing blood stasis, and relieving swelling. Can be used for treating heat stranguria, stranguria with stone, jaundice due to damp-heat, sore, carbuncle, swelling and pain, and traumatic injury.

Houttuynia cordata: pungent flavor and slightly cold in nature. It enters lung meridian. Has effects of clearing away heat and toxic materials, eliminating carbuncle, expelling pus, promoting urination, and treating stranguria. It can be used for treating pulmonary abscess with purulent vomiting, phlegm-heat with purulent vomiting, dysentery due to heat, stranguria due to heat, carbuncle, swelling, and sore.

Mint: pungent taste and cool nature. Enter liver and lung meridians. Has effects of dispelling pathogenic wind and heat, refreshing mind, relieving sore throat, promoting eruption, dispersing stagnated liver qi, and activating qi-flowing. Can be used for treating wind-heat type common cold, headache, conjunctival congestion, pharyngitis, aphtha, rubella, measles, and chest and hypochondrium swelling.

Cogongrass rhizome: sweet in flavor and cold in nature. It enters lung, stomach and bladder meridians. Has effects of cooling blood, stopping bleeding, clearing heat, promoting urination, clearing lung-heat and stomach-heat. Can be used for treating hematemesis due to blood heat, epistaxis, hematuria, fever polydipsia, jaundice due to damp-heat pathogen, edema, oliguria, stranguria with heat, and pain.

The medication principle and the prescription of the invention are as follows:

the prescription has the effects of clearing heat and promoting diuresis, and removing blood stasis and purging gallbladder, and is mainly used for acute cholecystitis caused by heat stagnation in the gallbladder and acute attack of chronic cholecystitis caused by damp-heat in the liver and gallbladder.

In the formula, bidens alba is used as a monarch drug for clearing heat and removing toxicity, and promoting diuresis and removing jaundice. The gentian clears heat and dries dampness, purges liver and gallbladder fire; herba Verbenae has effects of clearing away heat and toxic materials, promoting blood circulation, and removing blood stasis; the two drugs are used together as ministerial drugs for clearing heat to promote diuresis, and removing blood stasis to purge heat. Herba Hedyotidis Diffusae, herba Taraxaci, herba Solani Nigri, and herba Glechomae help herba Verbenae to clear away heat and toxic materials, promote blood circulation, and dissipate stagnation; the heartleaf houttuynia herb clears away heat and toxic materials, eliminates carbuncle and expels pus; the plantain and the lalang grass rhizome cool blood to stop bleeding, clear heat and induce diuresis, so that pathogenic factors can flow out, and damp heat is discharged from turbid tracts; the mint can disperse wind-heat, clear and disperse the upper energizer, regulate qi movement, and disperse dampness with wind, which are all adjuvant drugs. The compatibility of the prescription is characterized in that the prescription has the functions of clearing heat, promoting diuresis, promoting blood circulation and dissipating blood stasis, the functions of clearing heat, promoting diuresis, dissipating blood stasis, purging heat, moistening heat, purging heat with blood stasis, purging dampness with blood stasis and the like, and the effects of clearing heat, promoting diuresis, removing blood stasis and purging gallbladder are achieved with half the effort. The formula applies an evil-expelling passage method of strengthening medical treatment, achieves the purposes of dredging the passage and circulating qi and blood by dispelling dampness-heat evil toxin blocked in three passages, skillfully combines heat clearing and dampness removing with detoxification and stasis dissipating in the formula, has the effects of clearing heat and dampness, clearing liver and gallbladder, diminishing inflammation and relieving pain, and can promote bile duct to be unobstructed, normally secrete bile to be dredged and restore the functions of the liver and the gallbladder.

The invention has the beneficial effects that:

the traditional Chinese medicine composition is obtained according to the experimental results of folk medicine in Yunnan Wenshan region, adopts local folk medicine materials, has small toxic and side effects and low cost, has the curative effects of resisting infection and relieving pain which are not inferior to western medicine antibiotics or spasmolytic and analgesic medicines, and has lasting action time.

Clinical tests prove that the traditional Chinese medicine composition has a very good effect on treating acute cholecystitis due to stagnated heat in the gallbladder and acute attack of chronic cholecystitis due to damp heat in the liver and gallbladder, and the effective rate is as high as 100%.

Detailed Description

The present invention is further described in detail with reference to the following specific examples, but the scope of the present invention is not limited to the above description.

Example 1

A traditional Chinese medicine composition for treating cholecystitis comprises the following raw materials in parts by weight: 30 parts of bidens alba; 5 parts of gentian, 10 parts of oldenlandia diffusa, 5 parts of verbena, 10 parts of dandelion, 10 parts of black nightshade, 10 parts of plantain, 10 parts of longtube ground ivy herb, 10 parts of cordate houttuynia, 10 parts of mint and 10 parts of lalang grass rhizome.

Example 2

A traditional Chinese medicine composition for treating cholecystitis comprises the following raw materials in parts by weight: 40 parts of bidens alba; 8 parts of gentian, 12 parts of oldenlandia diffusa, 8 parts of verbena, 12 parts of dandelion, 12 parts of black nightshade, 12 parts of plantain, 12 parts of longtube ground ivy herb, 12 parts of cordate houttuynia, 12 parts of mint and 12 parts of lalang grass rhizome.

Example 3

A traditional Chinese medicine composition for treating cholecystitis comprises the following raw materials in parts by weight: 50 parts of bidens alba; 10 parts of gentian, 15 parts of oldenlandia diffusa, 10 parts of verbena, 15 parts of dandelion, 15 parts of black nightshade, 15 parts of plantain, 15 parts of longtube ground ivy herb, 15 parts of heartleaf houttuynia herb, 15 parts of mint and 15 parts of lalang grass rhizome.

The above embodiments are in grams, and different embodiments can be selected according to the disease condition of a patient, wherein one basic medicine is taken for two weeks, and two weeks are a treatment course. Generally, patients with mild illness can be basically cured after oral administration for one treatment course; the moderate or severe disease needs to be cured after two to three treatment courses. Simple cholecystitis can be cured, and calculous cholecystitis can be controlled and treated.

The clinical treatment:

1. general data: 150 patients, which meet the diagnosis standard of acute cholecystitis, are randomly divided into 3 groups, and 50 patients in each group have no obvious difference in sex, age, course of disease and severity of disease condition.

2. Diagnostic criteria:

symptoms and signs: pain in the right upper abdomen (which may be reflected to the right shoulder and back), palpable lump in the right upper abdomen/tenderness/muscular tension/rebound pain, positive Murphy sign;

② systemic inflammatory reaction: fever, elevated CRP levels, elevated WBC counts;

thirdly, ultrasonic inspection: the gallbladder volume is increased (the transverse diameter of the gallbladder is more than or equal to 4cm), the gallbladder wall is edema, and the gallbladder wall is thickened (more than or equal to 3mm) or rough.

3. Treatment criteria were:

level 0: no symptoms; stage I: the symptoms are slight and do not affect daily life; and II, stage: the moderate part of symptoms affects daily life; grade III: symptoms seriously affect daily life and difficulty in staying at work.

Evaluation criteria: the clinical recovery: the original symptoms disappear; secondly, effect is displayed: the original symptoms are obviously improved but are less than 0 grade; ③ effective: the original symptoms are improved but not reach grade II or grade I; fourthly, invalidation: the original symptoms are not improved or the original symptoms are aggravated.

4. The treatment method comprises the following steps:

the medicines in the embodiments 1-3 are taken, added with 4 times of weight of water, soaked for 1 hour, boiled for 25-35 minutes, filtered, added with water again, boiled for 3 times, and the filtrates are combined and taken three times a day, 200ml each time, and a treatment course is continuously taken.

Randomly dividing 150 patients into 3 groups, namely an experimental group 1, an experimental group 2 and an experimental group 3, wherein each group comprises 50 patients; experiment group 1 was treated with the drug of example 1, experiment group 2 was treated with the drug of example 2, experiment group 3 was treated with the drug of example 3, and treatment with other relevant drugs was discontinued during the administration period.

All patients had different degrees of right epigastric pain, abdominal tenderness, rebound pain; the B-ultrasonic wave can show the thickening of gallbladder or fright, and the image of calculus can be seen when the gallbladder is accompanied by calculus.

5. Therapeutic effects, as shown in Table 1

TABLE 1

	Number of examples	Cure of disease	Show effect	Is effective	Invalidation	Total effective rate
							Experimental group 1	50	40	4	6	0	100％
Experimental group 2	50	43	3	4	0	100％
							Experimental group 3	50	46	2	2	0	100％

From table 1, it can be seen that the traditional Chinese medicine composition has a very significant curative effect on treating acute cholecystitis.

The classical case:

case one: wenxju, female, age 41, teacher.

Symptoms and treatments: after the patient eats the fried eggs for 4 years, the feeling of fullness and dull pain of the stomach can be repeatedly caused, and the patient can automatically relieve the symptoms after taking the medicines for strengthening the spleen, promoting digestion, clearing heat and purging pathogenic fire. In 1999, the stomach feels full and dull pain again after eating and frying eggs in summer, the Chinese patent medicine for tonifying spleen and promoting digestion is not relieved after self-taking, and the right flank pain is dragged to the back and the scapular radioactive pain after 2 days, so the people feel uneasy to sit and lie, feel dysphoria, nausea, bitter taste in mouth and dry throat, and can not fall asleep at night. The patient is diagnosed with cholecystitis at local hospital. The pain is relieved after the injection (cephalosporin antibiotics, intramuscular injection 654-2 needles and the like) is infused in the morning every day until 17: 30 to 18: 00 again, relapse begins. The later patients require the conservative treatment of discharge by themselves, and the patients still show that the right flank pain involves the radiation pain of the back and the shoulder blades, the patients are uneasy to sit and lie down, feverish sensation in chest, nausea, bitter taste in mouth, dry throat, unable to fall asleep at night, dry stool, red tongue with yellow and greasy coating and wiry and rapid pulse. Afternoon 18 on the discharge date: 00 the first dose of the traditional Chinese medicine of example 1, spaced five hours to 23 pm: 00 the second time of taking the medicine, the pain is relieved at night, the patient goes to sleep quietly, after continuously taking the medicine for one period of treatment, the symptoms completely disappear, the gallbladder is checked to be normal by B ultrasonic, and the follow-up visit is not repeated. Diet contraindication: foods such as fried eggs and too greasy soup are contraindicated.

Case two: li x chang, man, age 62, retirement worker.

Symptoms and treatments: the radiation pain from the right flank to the back shoulder blade is mainly shown in 4 years of disease incidence, the local hospital diagnoses the cholecystitis, the cholecystitis can be prevented from infection and can be relieved after long-term repeated hospitalization and transfusion, and the cholecystitis can relapse after drinking and eating greasy food. The condition of a patient is aggravated after drinking wine in 1999, the patient is marked by radioactive knife-cut pain from right hypochondrium to back shoulder blade, the patient is hard to endure, accompanied by high fever, jaundice, bitter mouth and dry throat, vomiting yellow water when the patient can not eat the wine, the patient is hospitalized again, the patient is considered as 'cholecystitis occurs rapidly and cholangitis', the treatment is ineffective through anti-infection, cholagogic and analgesic treatment, local hospitals are under no policy, a notice of serious diseases is given, and the patient is discharged from hospital after being commented by family members; after going home, it still presents as radial incisional pain from the right flank to the back shoulder, severe and intolerable pain accompanied by high fever, yellow complexion and sclera, bitter mouth and dry throat, vomiting yellow water, inability to eat, sticky and difficult stools, red tongue with yellow and greasy coating, and wiry and smooth pulse. The traditional Chinese medicine in the embodiment 2 is used for treating hyperpyrexia and pain for 5 days, jaundice subsides after 10 days, the symptoms basically disappear after 21 days, B-ultrasonic examination is carried out after 2 months of continuous taking, and gallbladder is normal, and the disease does not relapse until the follow-up. Diet contraindication: fried food, eggs, and excessively greasy soup are contraindicated.

Case three: zhang Xloy, Man, 43 years old, and supply the power.

Symptoms and treatments: after 8 years of disease, the radiation dull pain and the paroxysmal pain from the lower part of the right flank rib to the shoulder blade of the back are the main manifestations, and the patients are misdiagnosed as liver cirrhosis by local county hospitals due to long-term drinking and jaundice, and repeated hospitalization has no effect. The diagnosis is carried out in spring 2006 in the hospital of the upper-level state, which is confirmed to be calculous cholecystitis and cholangitis, and the disease is still not improved after 10 days of anti-infection, cholagogue and analgesic treatment. After leaving home, it is manifested as radial colic from right flank to back shoulder blade, severe and intolerable symptoms, fever, hyperhidrosis, yellowing of skin and sclera, repeated nausea, vomiting, yellow and bitter water, anorexia, bitter taste in mouth, abdominal distention, yellow urine and difficult defecation. A dark red tongue with a thick and yellow coating and a wiry and slippery pulse. The pain and jaundice subside after continuously taking the traditional Chinese medicine for 20 days according to the traditional Chinese medicine treatment in the embodiment 3, and the traditional Chinese medicine is taken intermittently (the traditional Chinese medicine is taken automatically when the diet is not careful) so that the disease does not recur at present. Diet contraindication: fried food, eggs, greasy soup, beef, dog meat, etc. are avoided.

Case four: wangxfu, male, 55 years old, police.

Symptoms and treatments: patients repeatedly suffer from radioactive pain from the lower part of right hypochondrium ribs to shoulder blades on the back, the patients are diagnosed with cholecystitis in 1993, the cholecystitis is diagnosed in local hospitals, the cholecystitis is discharged after being improved through anti-infection, analgesia and cholagogic treatment, and the anti-inflammation cholagogic tablets are taken for a long time. But the treatment is repeated after the patient takes greasy food or beef or dog meat, and the patient is treated by intravenous drip of antibiotics and intramuscular injection of 654-2 needles, and even the patient is treated by intramuscular injection of dolantin when the patient is severely painful. In 2009, radiation colic and burning sensation from the lower part of the right rib to the shoulder blade of the back occur again after improper diet in summer, the patient is hard to endure, has profuse sweat, is dysphoric and irritative, and stops pain for a short time after acupuncture, the patient can be cured after two treatment courses of treatment according to the traditional Chinese medicine in the embodiment 2, and the gallbladder is examined normally by physical examination B every year, and the gallbladder is not relapsed until now. Diet contraindication: fried food, eggs, greasy soup, beef, dog meat, etc. are avoided.

Claims (2)

1. A traditional Chinese medicine composition for treating cholecystitis is characterized by comprising the following raw materials in parts by weight: 30-50 parts of bidens alba, 5-10 parts of felwort, 10-15 parts of oldenlandia diffusa, 5-10 parts of verbena, 10-15 parts of dandelion, 10-15 parts of black nightshade, 10-15 parts of plantain, 10-15 parts of longtube ground ivy, 10-15 parts of houttuynia cordata, 10-15 parts of mint and 10-15 parts of lalang grass rhizome.

2. The use of the Chinese medicinal composition for treating cholecystitis as claimed in claim 1 in the preparation of a medicament for treating cholecystitis.