CN111494427A - Method suitable for maintaining animal decoction pieces in pharmacy in medical institution - Google Patents
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Abstract
The invention relates to the technical field of maintenance of animal decoction pieces, in particular to a method for maintaining animal decoction pieces in a pharmacy in a medical institution. The invention relates to a method for preparing a small-package equivalent-quantity medicament for sealed storage by taking two decoction pieces of centipede and scorpion as outer packaging materials and a polyethylene composite film under the environment that the temperature is less than 30 ℃ and the humidity is 45-75%, and combining an antagonistic storage method, wherein the antagonistic stored medicament is pepper. The experimental result shows that the curing method has the advantages of high extract content, low water content, low total ash content and low aspergillus flavus content, good decoction piece stability and capability of ensuring the quality of the decoction pieces. The invention also comprises a system for maintaining the herbal pieces prepared for animals in the pharmacy. Its advantages are: the invention provides a method suitable for maintaining animal decoction pieces in a pharmacy in a medical institution for animal decoction pieces centipede and scorpion, so that the small-package decoction pieces have high extract content and low aspergillus flavus, moisture and total ash content, the quality of the decoction pieces is ensured, and the decoction pieces have good economic value and medicinal value.
Description
Technical Field
The invention relates to the technical field of maintenance of animal decoction pieces, in particular to a method for maintaining animal decoction pieces in a pharmacy in a medical institution.
Background
The application of the animal decoction pieces has a long history in China, has the effects of calming wind and relieving spasm, dispelling wind and relieving pain, dredging collaterals, promoting blood circulation and removing blood stasis and the like, has wide curative effect, but has the main components of protein[1]Amino acids, alkaloids, etc., which are difficult to store in daily use. From the clinical medication requirements of China at present, the requirements on animal decoction pieces are increasing and decreasing, and in order to meet the clinical medication requirements, scientific maintenance management research needs to be carried out besides the research on how to expand the sources of the decoction pieces, so that the quality of the decoction pieces is ensured, and the resource waste is avoided. The oxygen and carbon dioxide in the air have great influence on the deterioration of the animal decoction pieces due to the change of external environmental factors, and are easy to cause the phenomena of worm damage and mildew[2]It also affects the stability of the main ingredients inside the decoction pieces. The deteriorated decoction pieces not only reduce the original curative effect, but also harm the health of patients.
The centipede and the scorpion are expensive, clinically necessary, difficult to store and easy to change in quality, and the main components of the centipede and the scorpion contain protein, amino acid, alkaloid and the like. The scorpion contains protein, betaine, taurine and the like; the centipede contains protein, tyrosine, leucine, fatty oil and the like, and the spatial conformation of deteriorated chemical components is changed, so that the curative effect of the tablet is directly influenced. The centipede and scorpion decoction pieces are widely used clinically, and have obvious curative effect on nervous system, blood system, cardiovascular system, circulatory system and other aspects. From this point alone, it can be seen that the medicinal value of the two kinds of decoction pieces is very high. However, if the decoction pieces are improperly maintained and stored in daily life, the original active ingredients of the decoction pieces can be lost or reduced, so that the medicinal value is reduced. In addition, from the economic aspect, compared with the common plant decoction pieces, the animal decoction pieces have relatively less resources and are even scarce, so the cost is higher and the economic cost is higher. For example: compared with scorpion, the unit price of the uncaria is about 55 yuan per 500 g, while the unit price of the uncaria is about 2645 yuan per 500 g, and the difference between the uncaria and the scorpion is about 5 to 6 times. Therefore, the economic value of the animal decoction pieces is high. However, the small packaging of the same amount of the traditional Chinese medicine decoction pieces is just started in recent years, and the corresponding storage and maintenance measures are not perfect.
The traditional bulk decoction pieces are correspondingly prepared by temperature and humidity regulation and traditional maintenance methods, appearance quality change is not found, the small package materials are not breathable since the small package materials are used, water vapor is generated due to temperature and humidity changes, the small package materials are easy to change particularly in plum rain seasons of 6-10 months, the traditional maintenance method cannot be implemented, the temperature and humidity regulation effect is not ideal, mildew and worm damage phenomena occur, the quality safety of the decoction pieces is caused, and the clinical diagnosis medication effect is influenced.
Therefore, in order to prevent the decoction pieces from deteriorating, reduce direct economic loss and ensure the quality of the decoction pieces, the subject experiment starts from a novel subject matter, aims at the combination of small-package materials and traditional antagonistic storage, carries out observation and comparison, detects the extract content and aspergillus flavus, and explores the influence of the storage conditions of the animal decoction pieces and the packaging materials on the quality.
In the experiment, two kinds of animal decoction pieces are subjected to experimental comparison in the aspects of packaging materials and traditional decoction piece antagonistic maintenance under the normal temperature environment of a pharmacy in a medical institution (the temperature is less than 30 ℃ and the humidity is 45-75%), whether appearance characters of the decoction pieces are mildewed or damaged by worms is observed, the content of internal extract and detection of aspergillus flavus are compared with the standard of 2010 version pharmacopoeia of the people's republic of China to determine whether the internal extract content and the aspergillus flavus are changed, a proper packaging material is selected, a corresponding storage and maintenance method is formulated, and the effectiveness and the safety of the decoction pieces are guaranteed.
The method for maintaining the animal decoction pieces in the pharmacy suitable for medical institutions is not reported at present.
Reference documents:
[1] studies on chemical compositions of Scolopendra subspinipes, Fanghong and Denfen, collected from the 4 th phase of volume 32 of 4 months in 1997 in China journal of pharmacy
[2] The common fungus species in herbs, Shirui cotton, etc., were collected from journal of Chinese materia medica 1992, 6 (4).
Disclosure of Invention
The first purpose of the invention is to provide a method suitable for curing the herbal pieces for decoction of the pharmacy animals in the medical institution aiming at the defects of the prior art.
A second object of the present invention is to provide the use of the method as described above, in view of the drawbacks of the prior art.
The third purpose of the invention is to provide a small package animal decoction piece maintenance system aiming at the defects of the prior art.
In order to achieve the first purpose, the invention adopts the technical scheme that:
in the experiment, two kinds of animal decoction pieces are subjected to experimental comparison in aspects of packaging materials and traditional decoction piece antagonistic maintenance under the normal temperature environment of a pharmacy in a medical institution (the temperature is less than 30 ℃ and the humidity is 45-75%), whether appearance characters of the decoction pieces are mildewed or not and are damaged by worms is observed, meanwhile, the content of internal extract and aspergillus flavus detection are compared with the standard of 2010 version pharmacopoeia of the people's republic of China, whether the internal extract is changed or not is judged, a proper packaging material is selected, a corresponding storage and maintenance method is formulated, and the effectiveness and the safety of the decoction pieces are guaranteed.
A method for maintaining animal decoction pieces in a pharmacy suitable for medical institutions comprises the following steps: respectively taking animal decoction pieces, namely centipede and scorpion, using a polyethylene composite film as an outer packaging material under the environment that the temperature is less than 30 ℃ and the humidity is 45-75%, combining antagonistic storage, preparing small-package decoction pieces, and sealing and storing, wherein the antagonistic storage medicinal material is pepper; the maintenance conditions in plum rain season are as follows: under the environment that the temperature is less than 25 ℃ and the humidity is 45-75%, the polyethylene composite film is used as an outer packaging material, and the small-package decoction pieces are prepared for sealed storage by combining antagonistic storage.
Preferably, the method further comprises the step of detecting the quality of the small packaged decoction pieces, wherein the quality detection contents comprise color, smell, taste, extract content, aspergillus flavus content, moisture content and total ash content.
Preferably, the method for measuring the extract content comprises the following steps: the measurement was carried out by hot dipping method in the section of alcohol-soluble extract measurement method using ethanol as a solvent.
Preferably, the measuring method of the content of the aspergillus flavus comprises the following steps: performing fluorescence detection on the contents of Aspergillus flavus B1, Aspergillus flavus B2, Aspergillus flavus G1 and Aspergillus flavus G2 by using a high performance liquid chromatograph-iodine solution after column derivation method.
Preferably, the quality qualified standard of the centipede small-package decoction pieces is as follows: the extract content is more than or equal to 20.0 percent, the total ash content is less than or equal to 5.0 percent, the water content is less than or equal to 15.0 percent, and each 1000G of the extract contains 5 mu G of aspergillus flavus B1 and 10 mu G of the total amount of the aflatoxins G2, G1, B2 and B1; the quality standard of the small-package scorpion decoction pieces is as follows: the extract content is not less than 20.0%, and each 1000G extract contains Aspergillus flavus B1 of not more than 5 μ G, and aflatoxins G2, G1, B2, and B1 of not more than 10 μ G.
In order to achieve the second object, the invention adopts the technical scheme that:
the method is applied to the maintenance system for preparing the small-package animal decoction pieces.
In order to achieve the third object, the invention adopts the technical scheme that:
a system for maintaining small packages of animal decoction pieces, comprising:
an input module: used for inputting animal decoction pieces to be stored, such as Scorpio and Scolopendra;
and (3) a decoction piece maintenance module: is used for maintaining the imported animal decoction pieces scorpion and centipede, and the conditions are as follows: the temperature is less than 30 ℃, the humidity is 45-75%, the polyethylene composite film is used as an outer packaging material, and the small-package decoction pieces are prepared by combining antagonistic storage and sealed, wherein the antagonistic stored medicinal material is pepper; the maintenance conditions in plum rain season are as follows: under the environment that the temperature is less than 25 ℃ and the humidity is 45-75%, the polyethylene composite film is used as an outer packaging material, and the small packaged decoction pieces are prepared for sealed storage by combining antagonistic storage;
a quality detection module: quality detection is carried out on the small-package animal decoction pieces scorpion and centipede processed by the tablet curing module, and the detection contents comprise extract content, aspergillus flavus content, water content and total ash content;
an analysis module: the quality control module is used for analyzing and detecting whether the quality of the small-package decoction pieces is qualified or not, and if the small-package decoction pieces meet the quality qualified standard, the small-package decoction pieces are further transported to the output module through the transportation module; if the small-package decoction pieces do not meet the quality qualified standard, returning to the input module through the transportation module in the original way, wherein the original way returning specifically comprises the following steps: analysis module → quality detection module → decoction piece maintenance module → input module;
a transport module: used for transporting animal decoction pieces;
an output module: used for outputting small-package decoction pieces;
an information feedback module: the system is used for subsequent communication and feedback with doctors after the patient dispenses the medicine;
when small-package animal decoction pieces need to be taken, the quality detection module, the analysis module and the output module are started, and the input module and the decoction piece maintenance module are started in other time.
Preferably, the quality qualification criteria in the analysis module are: the centipede small-package decoction pieces are qualified in quality: the extract content is more than or equal to 20.0 percent, the total ash content is less than or equal to 5.0 percent, the water content is less than or equal to 15.0 percent, and each 1000G of the extract contains 5 mu G of aspergillus flavus B1 and 10 mu G of the total amount of the aflatoxins G2, G1, B2 and B1; the quality standard of the small-package scorpion decoction pieces is as follows: the extract content is not less than 20.0%, and each 1000G extract contains Aspergillus flavus B1 of not more than 5 μ G, and aflatoxins G2, G1, B2, and B1 of not more than 10 μ G.
Reference method for measuring extract content: pulverizing the sample, sieving with a second sieve, mixing, placing in a conical flask, adding ethanol, sealing, weighing, standing for one hour, connecting with a reflux condenser tube, heating to boil, and keeping slightly boiling for one hour. After cooling, the flask was removed, stoppered, weighed, replaced with ethanol, shaken well and filtered through a dry filter. Precisely measuring the filtrate, placing in an evaporating dish dried to constant weight, drying in water bath, drying at 105 deg.C for 3 hr, transferring to a dryer, cooling for 30 min, rapidly precisely weighing, and calculating the content (%) of alcohol-soluble extract in the sample with dried product except for other provisions.
The invention has the advantages that:
the experiment combines different packaging materials with antagonistic storage, explores a storage method suitable for small-package animal decoction pieces in a pharmacy in a medical institution, optimizes the maintenance conditions of the small-package animal decoction pieces, performs appearance identification, detects the extract content and aspergillus flavus of the decoction pieces, and explores the stable period of the quality of the decoction pieces. The result shows that the decoction piece obtained by the curing method has high extract content, low total ash content, low water content and low aspergillus flavus content, improves the medicinal value and ensures the economic value.
Drawings
FIG. 1 is a technical scheme of the invention.
Detailed Description
The invention will be further illustrated with reference to specific embodiments. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. Furthermore, it should be understood that various changes and modifications can be made by those skilled in the art after reading the disclosure of the present invention, and equivalents fall within the scope of the appended claims.
The invention carries out character identification and detection of extract and aspergillus flavus through the experimental comparison of the combination of the packaging material and the traditional maintenance method, inspects the stability of the main components of the animal decoction pieces and makes measures suitable for the storage and maintenance of the animal decoction pieces in the pharmacy in the medical institution.
Example 1
1 materials of the experiment
1.1 starting Material
Scorpio (Shanghai Huayu pharmaceutical Co., Ltd., batch No. HY2014122801), Scolopendra (Shanghai Huayu pharmaceutical Co., Ltd., batch No. XD 15022704); polyethylene composite film outer packaging, nonwoven material outer packaging, perforated polyethylene composite film outer packaging (Shanghai Huayu pharmaceutical Co., Ltd.); zanthoxylum bungeanum (shanghai huayu pharmaceutical co., ltd., lot No. DH 2015042902);
1.2 sample preparation
According to the standard of pharmacopoeia of the people's republic of China, 60 parts (3 g each) of scorpion samples packaged by polyethylene composite membrane materials, non-woven fabric materials and perforated polyethylene composite membrane materials are respectively taken, 10 parts of samples packaged by each material are respectively taken every month according to whether antagonistic storage is carried out or not, the samples are placed into an experimental area, and the experiment is carried out in 3 months. The effect of insect prevention and mildew prevention is achieved by selecting pepper in an antagonistic storage method (a traditional method). Observing appearance character changes (color, smell and taste) every day, judging whether the insects are mildewed or not, recording and photographing for sample reservation.
1.3 extract content and Aflatoxin detection
And entrusting a laboratory qualified by 'China qualification national committee laboratory approval certificate' every month, detecting whether the content of the main extract accords with the pharmacopoeia standard, and detecting whether the aflatoxin is generated.
2 method of experiment
2.1 first year:
collecting Scorpio and Scolopendra (in accordance with 2010 edition standard of pharmacopoeia of people's republic of China)
Experiment temperature: <30 deg.C (storage at room temperature)
Experiment humidity: 45 to 75 percent of
And (3) experimental observation: taking 240 parts (3 g each) of scorpion samples and 240 parts (3 g each) of centipede samples of different packaging materials, numbering I, II and III, putting the scorpion samples and the centipede samples into an experimental area according to different storage methods, and carrying out experiments in 4 months. The drug materials for resisting storage are: and (4) Chinese prickly ash.
Polyethylene composite film material
I (1) storage against challenge (10 parts per month for both samples)
I (2) storage against challenge was not performed (10 parts per month for both samples)
Nonwoven material II
II (1) storage against challenge (10 parts per month for both samples)
II (2) storage against challenge was not performed (10 parts per month for both samples)
III punching polyethylene composite film material
III (1) storage against challenge (10 parts per month for both samples)
III (2) storage against challenge not carried out (10 parts per month for both samples)
2.2 extract content and detection of Aspergillus flavus
Experiment time: the experimental period of the first year is 4 months (7 months, 1 day-10 months, 31 days)
(1) Observing once a day, recording appearance property changes (color, smell and taste) and temperature and humidity of the sample, and photographing for sample reservation;
(2) detecting the extract content and the aspergillus flavus every month, wherein a detection report is provided by a technical detection center of Shanghai Huayu pharmaceutical industry Limited;
in the second and third years:
according to the experimental result of the first year, the optimal packaging material is selected, the optimal packaging material is stored, and the pharmacy is experimentally popularized in the medical institution and the indexes are examined.
2.3 assessment indexes:
and (4) identifying and recording the experimental appearance, and observing photos, and detecting results of the extract and the aspergillus flavus.
And (4) qualified standard: standard of pharmacopoeia of the people's republic of China (2010 edition)
The characteristics are as follows:
scorpio-head and chest are green brown, back is green brown, and back is dark yellow, and has slight fishy smell and salty taste.
Centipede-head dark red or reddish brown, slightly glossy, belly light yellow or brown, foot yellow or reddish brown, even yellowish white, slightly fishy smell, special pungent odor and slightly salty taste.
The centipede small-package decoction pieces are qualified in quality: the extract content is more than or equal to 20.0 percent, the total ash content is less than or equal to 5.0 percent, the water content is less than or equal to 15.0 percent, and each 1000G of the extract contains 5 mu G of aspergillus flavus B1 and 10 mu G of the total amount of the aflatoxins G2, G1, B2 and B1; the quality standard of the small-package scorpion decoction pieces is as follows: the extract content is not less than 20.0%, and each 1000G extract contains Aspergillus flavus B1 of not more than 5 μ G, and aflatoxins G2, G1, B2, and B1 of not more than 10 μ G.
3 results
Table 1, 2015 scorpion data detection summary
Table 2, 2015 centipede data detection summary
TABLE 3 Total survey of appearance traits of Scorpio and Scolopendra at 7 months in 2015
TABLE 4 summary of appearance characteristics of Scorpio and Scolopendra in 2015 and 8 months
TABLE 5 summary of appearance characteristics of Scorpio and Scolopendra in 2015 and 9 months
TABLE 6 summary of appearance characteristics of Scorpio and Scolopendra in 2015 and 10 months
In the second year, carrying out daily observation (appearance character) on the scorpion samples packaged in different ways in a room temperature environment, recording the change of daily temperature and humidity, carrying out detection on the extract content and aspergillus flavus on the experimental samples every month, carrying out statistics summary, wherein the average temperature is 32.5 ℃, the average humidity is 64%, the phenomena of salting out, oil bleeding, deliquescence and the like appear when the appearance characters are observed, the detection results of the extract and the aspergillus flavus all accord with the standard of pharmacopoeia of people's republic of China, and the polyethylene composite membrane confrontation group has advantages;
TABLE 7 2016 Experimental sample test summary
TABLE 8 2016 Scorpion appearance Properties Observation general
Paper published in Anhui Chi institute of Union-Tibet medical school newspaper 2017 in 42-volume teaching Hospital album I in 2017, wherein influence of different external package storage conditions on scorpion medicinal material quality "
In the third year, according to the experimental results, a proper packaging material (polyethylene composite film and antagonistic storage) is selected, and the experiment is carried out in the pharmacy in the hospital; 200 patients were collected and submitted to clinical physician recommendations.
TABLE 9 Scorpion experiment feedback chart in 2017
According to the experimental results, the Chinese herbal medicine decoction piece quality special inspection in each year in the region is trained and learned for communication and popularization.
Hospital: and (4) standard purchase is carried out, and the packaging material selected according to the experimental result does not have the phenomenon of quality variation and the economic waste of loss under the specified temperature and humidity standard environment.
The patients: survey 200 patient feedback: the quality is stable within the period of prescription, reaches the standard, has no quality variation condition and has no quality complaint phenomenon of patients.
A physician: survey clinician (internal medicine, orthopedics, oncology, cardiology, encephalopathy) feedback: the quality is stable, the compatibility of clinical prescriptions is effective, and no patient reflects the condition of quality variation in clinical use.
Experiments show that the polyethylene confrontation group is relatively suitable for storage, and the proportion of water and total ash content is relatively not very high on the premise of ensuring the extract. Although the non-woven fabric has relatively low moisture content, the extract content is not very high, and the opaque packaging material is inconvenient for quality inspection of the decoction pieces. For the animal decoction pieces rich in protein, especially in plum rain high-temperature seasons, the temperature is easy to control and is less than 25 ℃, the humidity is 45-75% in the storage of a traditional Chinese medicine room allocation room, the small-packaged animal decoction pieces can be placed with peppers for antagonistic storage, and the quality stability is easy to ensure; meanwhile, clinicians are advised to reduce the number of posts as much as possible in plum rain seasons, so that long-time storage is avoided; the patients are informed of the special condition to store at low temperature, and the quality of the decoction pieces is ensured.
Through the experiment in this institute, select suitable packaging material and relative humiture, guarantee the quality stability of animal class sliced medicinal herbs, in the training study of "herbal pieces quality special examination" of the whole district of every year simultaneously, can use widely, drive the sliced medicinal herbs quality of whole district and further improve.
4. Discussion of the related Art
The suspected white crystal may be salt due to the processing method (salt boiling) of Scorpio. From this analysis, salt precipitation has a certain relationship with air moisture, and storage resistance plays a certain role in nonwoven fabrics. By comparison with the data of the samples, it was found that: the extract of Scorpio except polyethylene challenge and perforated polyethylene challenge 2 groups were decreased, and other 4 groups were increased, with the maximum increase being polyethylene challenge group.
The 4 groups of perforated polyethylene and non-woven fabric were in contact with air, so the color was lighter, the smell was relatively lighter, the worm body was drier, and salt precipitation was less. Through data comparison, the water content of the 6 groups is reduced, wherein the polyethylene is not antagonistic when the water content is reduced to the maximum extent; in the 6 groups, the total ash content of the polyethylene non-antagonistic group and the perforated polyethylene antagonistic group is reduced, and the other 4 groups are increased, wherein the maximum increasing amplitude is the non-woven fabric antagonistic group; in group 6, extractants in the polyethylene challenge group and the perforated polyethylene challenge group increased, and in the other 4 groups, extractants decreased.
Comparing with the data of August, it is found that only 2 groups of polyethylene have reduced water content detection, and other 4 groups have increased water content detection; the polyethylene non-antagonistic group and the non-woven fabric antagonistic group except the punched holes of the total ash content are slightly reduced, and the other 4 groups are all increased; the extracts were all elevated compared to the samples, with the largest amplitude being the polyethylene challenge.
According to the standard, every 1000g of aflatoxin B1-containing powder has the content of not more than 5 mu g; the total content of aflatoxins G2, G1, B2 and B1 is not more than 10 μ G. After detection, no aflatoxin is detected in 7-9 months.
The experiment of the first stage is carried out in the environment that the temperature of a traditional Chinese medicine dispensing room is less than 25 ℃ and the humidity is less than 65%, but the family of a patient does not have professional temperature control and dehumidification equipment, and the dispensing number is as large as 14-21, so that the quality change is easy to occur, the experiment of the second stage is carried out in the room with normal temperature and without direct sunlight, and the experiment period is 2 months (7-8 months).
The average temperature of July is 32 deg.C, and humidity is 64%. Under the environment of higher temperature and higher humidity, 6 groups of scorpions all excrete oily liquid. Comparing with the sample data, the moisture of the non-woven fabric 2 group is reduced, and the other 4 groups are increased, wherein the polyethylene antagonistic group with the maximum amplitude is obtained; the total ash content and extract content of 6 groups are increased, wherein the minimum increase of the total ash content is the non-woven fabric non-antagonistic group, and the maximum increase of the extract content is the perforated polyethylene non-antagonistic group.
The average temperature in August was 33 ℃ and humidity was 54%. Under the environment that the temperature is continuously raised and the humidity is reduced, the oily liquid of 6 groups of scorpion samples is reduced and even disappears; slightly salting out. Compared with the data of 7 months, the moisture content is reduced, and the maximum reduction is the non-woven fabric confrontation group; the total ash content of the polyethylene antagonistic group and the non-woven fabric antagonistic group rises, the other 4 groups all fall, and the maximum falling amplitude is the perforated polyethylene antagonistic group; the extractables of the non-woven fabric challenge group decreased slightly, and the extractables of the other 5 groups increased, with the polyethylene challenge group having the greatest amplitude.
According to the standard, every 1000g of aflatoxin B1-containing powder has the content of not more than 5 mu g; the total content of aflatoxins G2, G1, B2 and B1 is not more than 10 μ G. After detection, no aflatoxin is detected in 7-8 months.
In summary, in 6 experiments, the polyethylene challenge group was relatively suitable for storage, and the ratio of water content to total ash content was not very high on the premise of ensuring the extract. Although the non-woven fabric has relatively low moisture content, the extract content is not very high, and the opaque packaging material is inconvenient for quality inspection of the decoction pieces. For the animal decoction pieces rich in protein, especially in plum rain high-temperature seasons, the temperature is controlled to be lower than 25 ℃ and the humidity is controlled to be 45-75% in the storage of a traditional Chinese medicine room allocation room, the small-packaged animal decoction pieces can be stored in a confrontation manner by using pepper, and the quality stability is easy to maintain; the number of doses is recommended to be reduced as much as possible in the plum rain season, so that long-time storage is avoided; the patients are informed of the special condition to store at low temperature, and the quality of the decoction pieces is ensured.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and additions can be made without departing from the principle of the present invention, and these should also be considered as the protection scope of the present invention.
Claims (8)
1. A method for maintaining animal decoction pieces in a pharmacy suitable for medical institutions is characterized by comprising the following steps: respectively taking animal decoction pieces, namely centipede and scorpion, using a polyethylene composite film as an outer packaging material under the environment that the temperature is less than 30 ℃ and the humidity is 45-75%, combining antagonistic storage, preparing small-package decoction pieces, and sealing and storing, wherein the antagonistic storage medicinal material is pepper; the maintenance conditions in plum rain season are as follows: under the environment that the temperature is less than 25 ℃ and the humidity is 45-75%, the polyethylene composite film is used as an outer packaging material, and the small-package decoction pieces are prepared for sealed storage by combining antagonistic storage.
2. The method of claim 1, further comprising quality testing the packaged pieces, wherein the quality testing comprises color, odor, flavor, extract content, aspergillus flavus content, moisture content, total ash content.
3. The method according to claim 2, wherein the extract content is determined by: ethanol was used as a solvent, and the measurement was carried out by a hot dipping method in the alcohol-soluble extract measurement method.
4. The method according to claim 2, wherein the measuring method of the content of the aspergillus flavus is as follows: performing fluorescence detection on the contents of Aspergillus flavus B1, Aspergillus flavus B2, Aspergillus flavus G1 and Aspergillus flavus G2 by using a high performance liquid chromatograph-iodine solution after column derivation method.
5. The method as claimed in claim 1, wherein the quality standard of the centipede small-package decoction pieces is as follows: the extract content is more than or equal to 20.0 percent, the total ash content is less than or equal to 5.0 percent, the water content is less than or equal to 15.0 percent, and each 1000G of the extract contains 5 mu G of aspergillus flavus B1 and 10 mu G of the total amount of the aflatoxins G2, G1, B2 and B1; the quality standard of the small-package scorpion decoction pieces is as follows: the extract content is not less than 20.0%, and each 1000G extract contains Aspergillus flavus B1 of not more than 5 μ G, and aflatoxins G2, G1, B2, and B1 of not more than 10 μ G.
6. Use of the method of any one of claims 1-4 in the manufacture of a system for maintaining small packages of animal decoction pieces.
7. A system for maintaining small-package animal decoction pieces is characterized by comprising:
an input module: used for inputting animal decoction pieces to be stored, such as Scorpio and Scolopendra;
and (3) a decoction piece maintenance module: is used for maintaining the imported animal decoction pieces scorpion and centipede, and the conditions are as follows: the temperature is less than 30 ℃, the humidity is 45-75%, the polyethylene composite film is used as an outer packaging material, and the small-package decoction pieces are prepared by combining antagonistic storage and sealed, wherein the antagonistic stored medicinal material is pepper; the maintenance conditions in plum rain season are as follows: under the environment that the temperature is less than 25 ℃ and the humidity is 45-75%, the polyethylene composite film is used as an outer packaging material, and the small packaged decoction pieces are prepared for sealed storage by combining antagonistic storage;
a quality detection module: quality detection is carried out on the small-package animal decoction pieces scorpion and centipede processed by the tablet curing module, and the detection contents comprise extract content, aspergillus flavus content, water content and total ash content;
an analysis module: the quality control module is used for analyzing and detecting whether the quality of the small-package decoction pieces is qualified or not, and if the small-package decoction pieces meet the quality qualified standard, the small-package decoction pieces are further transported to the output module through the transportation module; if the small-package decoction pieces do not meet the quality qualified standard, returning to the input module through the transportation module in the original way, wherein the original way returning specifically comprises the following steps: analysis module → quality detection module → decoction piece maintenance module → input module;
a transport module: used for transporting animal decoction pieces;
an output module: used for outputting small-package decoction pieces;
an information feedback module: the system is used for subsequent communication and feedback with a doctor in the medication process of a patient;
when small-package animal decoction pieces need to be taken, the quality detection module, the analysis module and the output module are started, and the input module and the decoction piece maintenance module are started in other time.
8. The system of claim 7, wherein the quality qualification criteria in the analysis module are: the centipede small-package decoction pieces are qualified in quality: the extract content is more than or equal to 20.0 percent, the total ash content is less than or equal to 5.0 percent, the water content is less than or equal to 15.0 percent, and each 1000G of the extract contains 5 mu G of aspergillus flavus B1 and 10 mu G of the total amount of the aflatoxins G2, G1, B2 and B1; the quality standard of the small-package scorpion decoction pieces is as follows: the extract content is not less than 20.0%, and each 1000G extract contains Aspergillus flavus B1 of not more than 5 μ G, and aflatoxins G2, G1, B2, and B1 of not more than 10 μ G.
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