CN111481524A - Curcumin microencapsulation method - Google Patents
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- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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Abstract
The invention discloses a method for microencapsulating curcumin, which comprises the steps of dissolving curcumin in a solvent consisting of 8-10 times of ethyl acetate and ethanol in weight, adding tea saponin, fatty glyceride lactate and triglycerol monostearate, heating, and uniformly stirring to obtain a core material solution; taking phlorizin, mogroside V, rhamnolipid and xanthan gum as wall materials, adding water with the weight 10-15 times of that of the wall materials, uniformly stirring, and heating to 60-70 ℃ to obtain a capsule wall material solution; adding the core material solution into the capsule wall material solution according to the mass ratio of 1:2-4, adding into a homogenizer, and homogenizing to obtain a mixed solution; and (4) sending the mixed solution into a granulating sprayer for spray drying, and cooling to room temperature to obtain the curcumin microcapsule. The method microencapsulates the curcumin, so that the high-efficiency encapsulation of the curcumin can be effectively realized, the stability of the curcumin is improved, the storage period is prolonged, and the water solubility of the curcumin is improved; can also enhance the drug effects of curcumin microcapsule such as antioxidation, blood sugar reduction, anti-inflammation and the like, and cover the bad taste of curcumin.
Description
Technical Field
The invention relates to the technical field of medicinal preparations, in particular to a curcumin microencapsulation method.
Background
Curcumin (curcumin) is a natural effective component extracted from dried rhizome of Curcuma longa, Curcuma aromatica, and Curcuma zedoaria of Zingiberaceae. Curcumin is orange yellow crystal powder, slightly bitter in taste and insoluble in water, and is mainly used for coloring products such as sausage products, cans, sauced and marinated products and the like in food production. The medical research shows that curcumin has the effects of reducing blood fat, resisting tumor, resisting inflammation, benefiting gallbladder, resisting oxidation and the like.
At present, curcumin is only extracted from plants and dried to obtain dry powder for storage. But the curcumin dry powder is not protected by other media, and is easy to be oxidized and degraded under the action of illumination, high temperature and oxygen, so that the drug effect is reduced. The microcapsule technology is a technology of forming a microcapsule having a semipermeable or sealed capsule membrane by encapsulating a core material such as liquid, solid or gas with a natural or synthetic polymer material as a wall material. Because the microencapsulation can improve the physical properties of the encapsulated substance such as color, appearance, apparent density, solubility and the like; the stability of the core material is improved, and the reactivity, durability, heat sensitivity and photosensitivity of the coated material are improved, so that the coating material is widely applied to the industries of medicine, agriculture, chemicals, food processing, cosmetics and the like, and attracts the wide attention of the world. Therefore, microencapsulation of curcumin is an effective way to improve stability and prolong storage life.
Disclosure of Invention
The invention aims at solving the problems of poor stability and short storage period of the current curcumin. A method for microencapsulating curcumin is provided. The method microencapsulating the curcumin powder can effectively realize the high-efficiency encapsulation of the curcumin, improve the solubility, improve the stability of the curcumin, prolong the storage period and effectively improve the adhesive capacity of the microcapsule on the stomach of a human body; can also enhance the drug effects of curcumin microcapsule such as antioxidation, blood sugar reduction, anti-inflammation and the like, and cover the bad taste of curcumin.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
a method for microencapsulating curcumin comprises the following steps:
(1) dissolving curcumin in 8-10 times of solvent composed of ethyl acetate and ethanol, adding tea saponin, fatty glyceride lactate and triglycerol monostearate, heating, and stirring to obtain core material solution;
(2) taking phlorizin, mogroside V, rhamnolipid and xanthan gum as wall materials, adding water with the weight 10-15 times of that of the wall materials, uniformly stirring, and heating to 60-70 ℃ to obtain a capsule wall material solution;
(3) adding the core material solution into the capsule wall material solution according to the mass ratio of 1:2-4, adding into a homogenizer, and homogenizing to obtain a mixed solution;
(4) and (4) sending the mixed solution into a granulating sprayer for spray drying, and cooling to room temperature to obtain the curcumin microcapsule.
Further, the mass ratio of the curcumin to the tea saponin to the lactic acid fatty glyceride to the triglycerol monostearate is 100:3-5:4-8: 1-3.
Further, the volume ratio of the ethyl acetate to the ethanol is 1: 3-5.
Further, the mass ratio of phlorizin, mogroside V, rhamnolipid and xanthan gum in the wall material is 1-3:1-3:3-5: 20-30.
Further, homogenizing under 40-60MPa for 2-3 times, each time for 10-30 min.
Further, the spray drying process comprises the steps of atomizing at 0.08-0.10MPa, flowing at 10-15m L/min, introducing air at 140 ℃ and 70-90 ℃ and drying at 40-60m3/h。
Further, the drying is carried out until the water content is 4.0-5.5%.
Compared with the prior art, the invention has the advantages and beneficial effects that:
1. according to the method, the curcumin is microencapsulated by selecting a proper core material and wall material, so that the high-efficiency encapsulation of the curcumin can be effectively realized, the stability of the curcumin is improved, the storage period is prolonged, and the water solubility of the curcumin is effectively improved; can also enhance the drug effects of curcumin microcapsule such as antioxidation, blood sugar reduction, anti-inflammation and the like, and cover the bad taste of curcumin.
2. The tea saponin, the lactic acid fatty glyceride and the triglycerol monostearate are added to serve as core material raw materials, and the tea saponin serves as a natural non-ionic surfactant, so that the natural non-ionic surfactant has good functions of emulsification, dispersion, foaming, wetting and the like, improves the compatibility among the raw materials, has pharmacological effects of diminishing inflammation, easing pain, resisting permeation and the like, and is synergistic with the drug effect of curcumin; the lactic acid fatty acid glyceride and the triglycerol monostearate can improve the compatibility of oil and water, improve the water solubility of the curcumin, and the prepared curcumin microcapsule is stable and uniform.
3. The invention takes phlorizin, mogroside V, rhamnolipid and xanthan gum as wall materials, thereby not only improving the compactness of the microcapsule and being easier to coat the core material, but also ensuring the property of the microcapsule product to be more stable. The phlorizin and mogroside V can also improve the sweetness of the microcapsule particles of the curcumin and cover the bad taste of the curcumin, and the phlorizin also has the effects of reducing blood sugar, improving memory, resisting oxidation, resisting cancer and the like and is synergistic with the drug effect of the curcumin.
Detailed Description
The present invention will be described in further detail with reference to specific embodiments. It should be emphasized that the following description is merely exemplary in nature and is not intended to limit the scope of the invention or its application.
Example 1
A method for microencapsulating curcumin comprises the following steps:
(1) dissolving curcumin in a solvent composed of 10 times of ethyl acetate and ethanol (volume ratio is 1: 3), adding curcumin in an amount of 3.5% of tea saponin, 6% of fatty glyceride lactate and 2% of triglycerol monostearate, heating to 70 ℃, and uniformly stirring to obtain a core material solution;
(2) taking phlorizin, mogroside V, rhamnolipid and xanthan gum in a mass ratio of 2:3:5:25 as wall materials, adding water with the weight 15 times that of the wall materials, uniformly stirring, and heating to 70 ℃ to obtain a capsule wall material solution;
(3) adding the core material solution into the capsule wall material solution while the solution is hot, adding the capsule wall material solution into a homogenizer according to the mass ratio of 1:3, and homogenizing for 3 times under the pressure of 50MPa for 20min each time to obtain a mixed solution;
(4) the mixed solution is sent to a granulating sprayer for spray drying until the water content is 4.8 percent, and the spray drying process comprises the steps of atomizing pressure of 0.08MPa, flow rate of 15m L/min, air inlet temperature of 130 ℃, air exhaust temperature of 75 ℃ and flow rate of drying air of 50m3And h, cooling to room temperature to obtain the curcumin microcapsule.
The curcumin microcapsule prepared by the embodiment is detected to have the encapsulation rate of 95.27 percent and the water solubility of 31.24mg/m L.
The encapsulation efficiency is detected by high performance liquid chromatography, the encapsulation efficiency is × 100% of the mass of curcumin encapsulated in the microcapsule/the content of the curcumin encapsulated in the microcapsule and unencapsulated curcumin, linarin is used as a reference substance, 70% ethanol solution is added to prepare solution containing 50 mu g of curcumin per 1ml, 0.1 g of curcumin microcapsule is taken, 20ml of 70% ethanol is added, shaking is carried out evenly, filtering is carried out, filtrate is taken, and the detection wavelength is 425 nm.
The water solubility determination method comprises adding 0.5g curcumin microcapsule into 100ml water, ultrasonic stirring for 30min, centrifuging to remove precipitate, and collecting supernatant to detect curcumin content. The water solubility was calculated from the curcumin content.
Example 2
A method for microencapsulating curcumin comprises the following steps:
(1) dissolving curcumin in a solvent composed of ethyl acetate and ethanol (volume ratio is 1: 4) with the weight of 9 times, adding curcumin with the mass of 4% of tea saponin, 5% of lactic acid fatty glyceride and 1.5% of triglycerol monostearate, heating to 65 ℃, and uniformly stirring to obtain a core material solution;
(2) taking phlorizin, mogroside V, rhamnolipid and xanthan gum in a mass ratio of 1:1:3:20 as wall materials, adding water with the weight being 10 times of that of the wall materials, uniformly stirring, and heating to 65 ℃ to obtain a capsule wall material solution;
(3) adding the core material solution into the capsule wall material solution while the solution is hot, adding the capsule wall material solution into a homogenizer according to the mass ratio of 1:2, and homogenizing for 2 times under the pressure of 60MPa for 30min each time to obtain a mixed solution;
(4) the mixed solution is sent to a granulating sprayer for spray drying until the water content is 4.6 percent, and the spray drying process comprises the steps of atomizing at 0.09MPa, flowing at 12m L/min, feeding air at 140 ℃, discharging air at 80 ℃ and drying air at 45m3The curcumin microcapsule prepared in the embodiment has the encapsulation rate of 91.96% and the water solubility of 28.22mg/m L through detection.
Example 3
A method for microencapsulating curcumin comprises the following steps:
(1) dissolving curcumin in a solvent composed of 10 times of ethyl acetate and ethanol (volume ratio is 1: 3), adding curcumin in an amount of 3.5% of tea saponin, 7% of fatty glyceride lactate and 2.5% of triglycerol monostearate, heating to 60 ℃, and uniformly stirring to obtain a core material solution;
(2) taking phlorizin, mogroside V, rhamnolipid and xanthan gum in a mass ratio of 3:2:5:30 as wall materials, adding water with the weight being 12 times of that of the wall materials, uniformly stirring, and heating to 60 ℃ to obtain a capsule wall material solution;
(3) adding the core material solution into the capsule wall material solution while the solution is hot, adding the capsule wall material solution into a homogenizer according to the mass ratio of 1:4, and homogenizing for 3 times under the pressure of 50MPa for 15min each time to obtain a mixed solution;
(4) the mixed solution is sent to a granulating sprayer for spray drying until the water content is 5.2%, and the spray drying process comprises the steps of atomizing at 0.09MPa, flowing at 10m L/min, feeding air at 130 ℃, discharging air at 70 ℃ and drying air at 50m3And h, cooling to room temperature to obtain the curcumin microcapsule. .
The curcumin microcapsule prepared by the embodiment is detected to have the encapsulation rate of 93.41 percent and the water solubility of 34.85mg/m L.
The foregoing is a more detailed description of the invention in connection with specific/preferred embodiments and is not intended to limit the practice of the invention to those descriptions. It will be apparent to those skilled in the art that various substitutions and modifications can be made to the described embodiments without departing from the spirit of the invention, and such substitutions and modifications are to be considered as within the scope of the invention.
Claims (7)
1. A method for microencapsulating curcumin is characterized in that: the method comprises the following steps:
(1) dissolving curcumin in 8-10 times of solvent composed of ethyl acetate and ethanol, adding tea saponin, fatty glyceride lactate and triglycerol monostearate, heating, and stirring to obtain core material solution;
(2) taking phlorizin, mogroside V, rhamnolipid and xanthan gum as wall materials, adding water with the weight 10-15 times of that of the wall materials, uniformly stirring, and heating to 60-70 ℃ to obtain a capsule wall material solution;
(3) adding the core material solution into the capsule wall material solution according to the mass ratio of 1:2-4, adding into a homogenizer, and homogenizing to obtain a mixed solution;
(4) and (4) sending the mixed solution into a granulating sprayer for spray drying, and cooling to room temperature to obtain the curcumin microcapsule.
2. A method of microencapsulation of curcumin as claimed in claim 1, wherein: the mass ratio of the curcumin to the tea saponin to the lactic acid fatty glyceride to the triglycerol monostearate is 100:3-5:4-8: 1-3.
3. A method of microencapsulation of curcumin as claimed in claim 1, wherein: the volume ratio of the ethyl acetate to the ethanol is 1: 3-5.
4. A method of microencapsulation of curcumin as claimed in claim 1, wherein: the mass ratio of phlorizin, mogroside V, rhamnolipid and xanthan gum in the wall material is 1-3:1-3:3-5: 20-30.
5. A method of microencapsulation of curcumin as claimed in claim 1, wherein: the homogenizing is carried out under 40-60MPa for 2-3 times, each time for 10-30 min.
6. The method for microencapsulating curcumin as claimed in claim 1, wherein the spray drying process comprises the steps of atomizing at 0.08-0.10MPa, flowing at 10-15m L/min, introducing air at 120-140 ℃, exhausting at 70-90 ℃, and drying at 40-60m3/h。
7. A method of microencapsulation of curcumin as claimed in claim 6, wherein: the drying is carried out until the water content is 4.0-5.5%.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115669942A (en) * | 2022-10-31 | 2023-02-03 | 成都大学 | Curcumin-bamboo bird's nest polysaccharide composite microcapsule and preparation method thereof |
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| CN115669942B (en) * | 2022-10-31 | 2023-11-03 | 成都大学 | Curcumin-bamboo bird nest polysaccharide composite microcapsule and preparation method thereof |
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Application publication date: 20200804 |