CN111465699A - 在盐沉淀下通过转氨酶反应由羰基化合物制备胺的方法 - Google Patents

在盐沉淀下通过转氨酶反应由羰基化合物制备胺的方法 Download PDF

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CN111465699A
CN111465699A CN201880074226.2A CN201880074226A CN111465699A CN 111465699 A CN111465699 A CN 111465699A CN 201880074226 A CN201880074226 A CN 201880074226A CN 111465699 A CN111465699 A CN 111465699A
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alkyl
branched
residue
hydrogen atom
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CN111465699B (zh
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扬·冯朗格曼
丹尼斯·胡斯韦德
马尔科·滕茨勒
乌尔夫·梅尼耶斯
菲利普·聚斯
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Enzimix
Universitaet Rostock
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Universitaet Rostock
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/62—Quaternary ammonium compounds
    • C07C211/63—Quaternary ammonium compounds having quaternised nitrogen atoms bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
CN201880074226.2A 2017-11-17 2018-11-16 在盐沉淀下通过转氨酶反应由羰基化合物制备胺的方法 Active CN111465699B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17202282.4A EP3486324B1 (en) 2017-11-17 2017-11-17 Method for preparing amines from carbonyl compounds by transaminase reaction under salt precipitation
EP17202282.4 2017-11-17
PCT/EP2018/081517 WO2019096973A1 (en) 2017-11-17 2018-11-16 Method for preparing amines from carbonyl compounds by transaminase reaction under salt precipitation

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CN111465699A true CN111465699A (zh) 2020-07-28
CN111465699B CN111465699B (zh) 2024-09-20

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Country Status (8)

Country Link
US (1) US12018303B2 (ja)
EP (1) EP3486324B1 (ja)
JP (1) JP7250807B2 (ja)
KR (1) KR102554463B1 (ja)
CN (1) CN111465699B (ja)
DK (1) DK3486324T3 (ja)
ES (1) ES2816102T3 (ja)
WO (1) WO2019096973A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022143977A1 (zh) * 2020-12-31 2022-07-07 上海合全药物研发有限公司 一种转氨酶及使用其进行催化制备的方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3486324T3 (da) * 2017-11-17 2020-09-14 Enzymicals Ag Fremgangsmåde til fremstilling af aminer fra carbonylforbindelser ved transaminasereaktion under saltudfældning
US20220380817A1 (en) * 2019-10-25 2022-12-01 Asymchem Laboratories (Fuxin) Co., Ltd. Transaminase mutant and use thereof
CN111235127B (zh) * 2020-04-29 2020-08-14 凯莱英医药集团（天津）股份有限公司 转氨酶突变体及其应用
CN117567270B (zh) * 2023-11-20 2024-08-09 江南大学 一种醇胺-壬二酸超分子离子盐及其制备和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011026556A1 (en) * 2009-09-02 2011-03-10 Lonza Ag A process for the identification and preparation of a (r)-specific omega-transaminase
EP3486324A1 (en) * 2017-11-17 2019-05-22 Enzymicals AG Method for preparing amines from carbonyl compounds by transaminase reaction under salt precipitation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007042600A1 (de) 2007-09-07 2009-03-12 Evonik Degussa Gmbh Verfahren zur Herstellung von enantiomerenangereichten Aminen
JP2013507145A (ja) 2009-10-13 2013-03-04 ゲノマチカ， インク． １，４−ブタンジオール、４−ヒドロキシブタナール、４−ヒドロキシブチリル−ＣｏＡ、プトレシン及び関連化合物の生成のための微生物体並びに関連する方法
MX350510B (es) 2010-07-14 2017-09-08 Patheon Austria Gmbh & Co Kg Aminación (r)-selectiva.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011026556A1 (en) * 2009-09-02 2011-03-10 Lonza Ag A process for the identification and preparation of a (r)-specific omega-transaminase
EP3486324A1 (en) * 2017-11-17 2019-05-22 Enzymicals AG Method for preparing amines from carbonyl compounds by transaminase reaction under salt precipitation

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BORNER ET AL: "A process concept for high-purity production of amines by transaminase-catalyzed asymmetric synthesis: combining enzyme cascade and membrane-assisted ISPR", 《ORGANIC PROCESS RESEARCH & DEVELOPMENT》, vol. 19, pages 793 - 799, XP055265098, DOI: 10.1021/acs.oprd.5b00055 *
BUQUE-TABOADA ET AL: "In situ product recovery(ISPR)by Crystallization：basic principles, design， and potential applications in whole-cell biocatalysis", 《APPLIED MICROBIOLOGY AND BIOTECHNOLOGY》, vol. 71, pages 1 - 12 *
HEINTZ ET AL: "Development of in situ product removal strategies in biocatalysis applying Scaled-down unit operations", 《BIOTECHNOLOGY AND BIOENGINEERING》, vol. 114, no. 12, pages 600 - 609, XP055676421, DOI: 10.1002/bit.26191 *
HOLSEWEDE ET AL: "Development of an in situ-product crystallization (ISPC)-concept to shift the reaction equilibria_of selected amine transaminase-catalyzed reactions", 《EUROPEAN JOURNAL OF ORGANIC CHEMISTRY》, pages 1 - 5 *
HULSEWEDE ET AL: "Application of in situ product crystallization and related techniques in biocatalytic processes", 《CHEMISTRY - A EUROPEAN JOURNAL》, vol. 25, no. 2, pages 1 - 15, XP002788836 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022143977A1 (zh) * 2020-12-31 2022-07-07 上海合全药物研发有限公司 一种转氨酶及使用其进行催化制备的方法

Also Published As

Publication number Publication date
CN111465699B (zh) 2024-09-20
EP3486324A1 (en) 2019-05-22
JP2021503306A (ja) 2021-02-12
US20230167472A9 (en) 2023-06-01
JP7250807B2 (ja) 2023-04-03
KR20200110641A (ko) 2020-09-24
ES2816102T3 (es) 2021-03-31
KR102554463B1 (ko) 2023-07-12
DK3486324T3 (da) 2020-09-14
EP3486324B1 (en) 2020-06-10
US12018303B2 (en) 2024-06-25
US20220162654A1 (en) 2022-05-26
WO2019096973A1 (en) 2019-05-23

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