CN1114578A - Oral medicine for curing seborrheic baldness - Google Patents
Oral medicine for curing seborrheic baldness Download PDFInfo
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- CN1114578A CN1114578A CN 95103685 CN95103685A CN1114578A CN 1114578 A CN1114578 A CN 1114578A CN 95103685 CN95103685 CN 95103685 CN 95103685 A CN95103685 A CN 95103685A CN 1114578 A CN1114578 A CN 1114578A
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- medicine
- vitamin
- acutane
- polygoni multiflori
- seborrheic alopecia
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Abstract
The present invention discloses a medicine for treating seborrheic baldness. It is an oral medicine made up by using 13-cis-vitamin A acid and vitamin B2 and adding the extracts of the Chinese medicine ingredients and in the concrete, it is a made up by using 13-cis-vitamin A acid, vitamin B2, fleece-flower root and red sage root. Said medicine can effectively cure seborrheic baldness, and its toxic side effect is low.
Description
The present invention relates to a kind of medicine for the treatment of seborrheic alopecia.A kind of specifically oral medicine made from Chinese herbal medicine and vitamin medicaments cooperation.
Alopecia is a kind of dermatosis of common pilosity, mainly is divided into two types, promptly non-seborrheic alopecia (bald as class) and seborrheic alopecia.The treatment of non-seborrheic alopecia is easier, existing many effective patent medicine.Non-seborrheic alopecia just has curative effect preferably to class is bald etc. as the medicine made by Chinese medicines such as Radix Polygoni Multiflori, Fructus Lycii.Yet for seborrheic alopecia, these medicines almost can be described as invalid or curative effect very little.The treatment of seborrheic alopecia can be described as a difficult problem of current dermatology circle, though people have done many effort, does not still have real effectively medicine and Therapeutic Method so far and comes out.
The essential cause of disease of seborrheic alopecia is still not really clear at present, but it is generally acknowledged may with androgen secretion cross prosperous relevant because few people suffer from seborrheic alopecia among the women.As if yet it is not the immediate cause of seborrheic alopecia again that androgen secretion is crossed prosperous.It is reported that the medicine that has the people to take the antiandrogen class once for the seborrheic alopecia patient is treated seborrheic alopecia with the concentration that reduces androgen in the blood of human body, but does not have what effect.The immediate cause that it is considered herein that seborrheic alopecia is because the human endocrine imbalance causes that sebum secretion is prosperous excessively, and in the too much sebum contained some material such as oleic acid, linoleic acid, Squalene etc. to the toxic effect of hair follicle, cause hair to poison, wither, come off, thereby prove that it may be the immediate cause of seborrheic alopecia that sebum secretion is crossed prosperous.From last surface analysis as can be known, at first should want effectively to suppress or to reduce the excessive secretion of scalp fat to the real effectively medicine of seborrheic alopecia.
From the forties, just have the human vitamin A to treat acne, acne also is owing to sebum secretion is crossed the prosperous dermatosis that causes, but the ability of vitamin A inhibition sebum secretion is very not strong, and bigger toxic and side effects is arranged, comprise xerosis cutis, headache, osteodynia, alopecia etc.In recent decades, on the basis of vitamin A, successively synthesize hundreds of kind retinoid material and come safer and more effective treatment acne.These materials all have the effect of obvious suppression sebum secretion.Yet it also is incomplete only treating seborrheic alopecia with the retinoid material.The most of scalp hair follicles of seborrheic alopecia patient are impaired serious, and the atrophy of scalp blood capillary causes hair malnutrition.Though only can reduce the toxic action that is subjected to the elimination hair follicle, but still can not stop the impaired alopecia of hair follicle with the treatment of retinoid material.The observed clinically fact of the inventor is that even use the retinoid material to treat, many patient's hairs still can undesiredly constantly come off.
The inventor had once applied for a kind of medicine (application number 92113387.1) for the treatment of seborrheic alopecia in 92 years, this application is to cooperate Chinese medicine Radix Polygoni Multiflori, Semen Cuscutae, Fructus Mori, Fructus Ligustri Lucidi, Herba Ecliptae to make capsule with Viaminate.But this effect of drugs is still not ideal, and if the Viaminate use amount excessive, have the side effect that causes alopecia on the contrary, symptoms such as cheilitis also can appear in the patient who has, and are not suitable for clinical practice.Through clinical practice in a few years, the inventor has newly formulated and a kind ofly can effectively treat seborrheic alopecia and the less medicine of side effect.
The object of the invention provides a kind of medicine for the treatment of seborrheic alopecia, and this medicine is significantly less than the toxic and side effects of medicine in the past, and therapeutic effect is good.
The prescription of medicine of the present invention is formed:
Radix Polygoni Multiflori 4-10 gram
Ro acutane 6-10 milligram
Vitamin B
2The 50-80 milligram
Ro acutane in the prescription can effectively suppress sebum secretion, thereby control the alopecia that causes because of hypersteatosis to a certain extent, the inventor finds separately Ro acutane and Chinese medicine Radix Polygoni Multiflori to be used clinically, although want certain therapeutic effect, but very big toxic and side effects is arranged, cause side effect such as dry mouth and parching tongue, cheilitis, xerosis cutis desquamation, eye mucosa drying, conjunctivitis easily.And with Ro acutane and vitamin B
2When being used, can reduce this side effect to a large extent.Add the Chinese medicine Radix Polygoni Multiflori again, then can reach ideal therapeutic effect.
According to the theory of the traditional Chinese medical science, QI and blood is obstructed, and the fur of can not leading to, hair lose QI and blood and moisten fosterly, also are one of reasons that causes alopecia, therefore, on above-mentioned prescription basis, adds the salviamiltiorrhizabung of invigorating blood circulation again, can promote the growth of hair better.The medicine of following formulation is on the one hand when using Ro acutane to suppress sebum secretion, because with Ro acutane and vitamin B
2Be used, reduced the side effect of Ro acutane, on the other hand, adding Radix Polygoni Multiflori can blood nourishing and hair, adds Radix Salviae Miltiorrhizae again, and promoting blood circulation to remove obstruction in the collateral makes normal circulation of qi and blood, nourishes hair, reaches the effect of hair growth promoting jointly.Thus, the medicine of following formulation has demonstrated fully the inventor's inventive concept.It also is one of preferred version of the present invention.
Radix Polygoni Multiflori 4-10 gram Radix Salviae Miltiorrhizae 2-5 gram
Ro acutane 6-10 milligram
Vitamin B
2The 50-80 milligram
Ro acutane and vitamin B
2Proportion be 1: 1-1: 10, the best is 1: 7.
If Ro acutane and vitamin B
2Be used, do not add Chinese medicine ingredients, also can reach the purpose of eliminating toxic and side effects, but add after the Chinese medicine ingredients, the effect of treatment alopecia improves greatly.
Therefore, the inventor adopts the medicine of following formulation, also can reach the effect of treatment seborrheic alopecia:
Ro acutane 6-12 milligram
Vitamin B
2The 50-80 milligram
But, add Chinese medicine ingredients Radix Polygoni Multiflori and Radix Salviae Miltiorrhizae on this basis, then can reach ideal therapeutic effect.
In recent clinical practice, find,, can also add Chinese medicine Semen Cuscutae, Fructus Ligustri Lucidi or Radix Angelicae Sinensis in the above-mentioned prescription according to different clinical manifestations, and Western medicine pantothenic acid, inositol, cystine etc.
All-trans-retinoic acid is a kind of retinoid medicine close with Ro acutane, in preparation said medicine process, if Ro acutane is replaced by all-trans-retinoic acid, also can reach the ideal effect of treatment seborrheic alopecia.
Therefore, the inventor has also developed a kind of medicine for the treatment of seborrheic alopecia in addition, and the prescription composition for preparing this medicine is:
Radix Polygoni Multiflori 4-10 gram Radix Salviae Miltiorrhizae 2-5 gram
All-trans-retinoic acid 6-10 milligram
Vitamin B
2The 50-80 milligram
All-trans-retinoic acid and vitamin B
2Proportion be 1: 1-1: 10, the best is 1: 7.
Medicine of the present invention can be prepared into the various oral medicine dosage forms of using clinically, for example, and tablet, electuary, capsule, pill etc.
The preparation method of medicine of the present invention can be conventional.Such as, can be with the Chinese medicine extraction effective ingredient, system cream, oven dry, pulverizing are made the oiliness microcapsule with the retinoid material, and Chinese medicinal powder is mixed with microcapsule and vitamin(e) B group material mix thoroughly again, the hard capsule of packing into, or add certain excipient and be pressed into tablet.Equally, can will impel Western medicine and retinoid medicament microcapsule, the vitamin(e) B group medicament mixed of hair growth to mix thoroughly, the hard capsule of directly packing into, or add certain excipient and be pressed into tablet.Perhaps, the retinoid medicine is made oily solution, add the mixing of other Chinese medicines and western medicine composition and mix thoroughly, make soft capsule.
Clinical data shows, cooperates the medicine of making by this two biostearins material, and the treatment of seborrheic alopecia is had very ideal effect.This is because this two classes medicine can make up for each other's deficiencies and learn from each other after combination, complements each other, and demonstrates good cooperative effect, has surpassed the effect for the treatment of with single class medicine greatly.Because Ro acutane and all-trans-retinoic acid have been eliminated the deleterious factor of hair follicle, hair growth nutrient mass-energy is played a role, improved the nutritional status of hair, thereby can prevent undesired alopecia completely, improve old state widely, and promoted New Development regeneration.Vitamin B
2Adding, reduced the toxic and side effects of said vitamin category-A material, the adding of Chinese medicine ingredients has been strengthened nourishing blood, has been invigorated blood circulation, the effect of hair growth promoting.Succeeding in developing of medicine of the present invention overcome the difficult problem of seborrheic alopecia treatment clinically, reduced the toxic and side effects of clinical application, provides a kind of effectively less medicine of toxic and side effects for treating seborrheic alopecia clinically.
Through the geriatric hospital, Fujian Province, attached Concord Hospital of Fujian Province's dermatopathy and venereal disease prophylactico-therapeutic hospital, Fujian Medical College three tame hospital clinicals observe, medicine of the present invention has the effect of obvious treatment seborrheic alopecia, the geriatric hospital, Fujian Province is observed the patient of 35 routine seborrheic alopecia, the result is an obvious effective rate 68.6%, effective percentage 100%.
Provide some embodiment below, further describe the present invention in further detail.
Embodiment 1:
30 milligrams of vitamin Bs of Ro acutane
2150 milligrams
Embodiment 2:
10 milligrams of vitamin Bs of Ro acutane
270 milligrams
Embodiment 3:
10 milligrams of vitamin Bs of Ro acutane
270 milligrams
Radix Polygoni Multiflori 5 grams
Radix Polygoni Multiflori is decocted with water, extracting liquid filtering, concentrating under reduced pressure, oven dry is pulverized, and sieves, and makes medicated powder.Ro acutane is made the oiliness microcapsule, then with Radix Polygoni Multiflori dry powder and vitamin B
2Be mixed together and mix thoroughly, incapsulate.
Embodiment 4:
10 milligrams of vitamin Bs of Ro acutane
270 milligrams
Radix Polygoni Multiflori 4 gram Radix Salviae Miltiorrhizaes 2 grams
Radix Polygoni Multiflori and Radix Salviae Miltiorrhizae are decocted with water respectively, extracting liquid filtering, concentrating under reduced pressure, oven dry is pulverized, and sieves, and makes medicated powder.Ro acutane is made the oiliness microcapsule, then with the dry powder and the vitamin B of Radix Polygoni Multiflori and Radix Salviae Miltiorrhizae
2Be mixed together and mix thoroughly, incapsulate.
Embodiment 5:
10 milligrams of vitamin Bs of Ro acutane
270 milligrams
Radix Polygoni Multiflori 7.5 gram Radix Salviae Miltiorrhizaes 2 grams
Semen Cuscutae 2 gram Fructus Ligustri Lucidi 2 grams
Radix Angelicae Sinensis 2 grams
Radix Polygoni Multiflori, Radix Salviae Miltiorrhizae, Semen Cuscutae, Fructus Ligustri Lucidi, Radix Angelicae Sinensis are decocted with water respectively, extracting liquid filtering, concentrating under reduced pressure, oven dry is pulverized, and sieves, and makes medicated powder.Ro acutane is made the oiliness microcapsule, then with the dry powder and the vitamin B of above-mentioned Chinese medicine
2Be mixed together and mix thoroughly, incapsulate.
Embodiment 6
10 milligrams of vitamin Bs of all-trans-retinoic acid
270 milligrams
Radix Polygoni Multiflori 5 grams
Radix Polygoni Multiflori is decocted with water, extracting liquid filtering, concentrating under reduced pressure, oven dry is pulverized, and sieves, and makes medicated powder.All-trans-retinoic acid is made the oiliness microcapsule, then with Radix Polygoni Multiflori dry powder and vitamin B
2Be mixed together and mix thoroughly, incapsulate.
Embodiment 7:
10 milligrams of vitamin Bs of all-trans-retinoic acid
270 milligrams
Radix Polygoni Multiflori 5 gram Radix Salviae Miltiorrhizaes 2 grams
Radix Polygoni Multiflori and Radix Salviae Miltiorrhizae are decocted with water respectively, extracting liquid filtering, concentrating under reduced pressure, oven dry is pulverized, and sieves, and makes medicated powder.All-trans-retinoic acid is made the oiliness microcapsule, then with the dry powder and the vitamin B of Radix Polygoni Multiflori and Radix Salviae Miltiorrhizae
2Be mixed together and mix thoroughly, incapsulate.
Claims (9)
1, a kind of endo-medicine for the treatment of seborrheic alopecia is characterized in that it is the medicament of being made by following component:
Radix Polygoni Multiflori 4-10 gram Radix Salviae Miltiorrhizae 2-5 gram
Ro acutane 6-10 milligram
Vitamin B
2The 50-80 milligram
2, medicine according to claim 1, wherein said Radix Polygoni Multiflori and Radix Salviae Miltiorrhizae consumption are meant the required crude drug consumption of preparation medicament of the present invention.
3, medicine according to claim 1 and 2, wherein Ro acutane and vitamin B
2Proportion be 1: 1-1: 10.
4, medicine according to claim 3, wherein Ro acutane and vitamin B
2Proportion be 1: 1-1: 7.
5, medicine according to claim 1 is characterized in that it is the medicament of being made by following component:
Radix Polygoni Multiflori 5 gram Radix Salviae Miltiorrhizaes 2 grams
10 milligrams of Ro acutanes
Vitamin B
270 milligrams
6, a kind of endo-medicine for the treatment of seborrheic alopecia is characterized in that it is the medicament of being made by following component:
Radix Polygoni Multiflori 5 grams
10 milligrams of Ro acutanes
Vitamin B
270 milligrams
7, a kind of endo-medicine for the treatment of seborrheic alopecia is characterized in that it contains:
Ro acutane 6-12 milligram
Vitamin B
2The 50-80 milligram
8, medicine according to claim 8, wherein Ro acutane and vitamin B
2Proportion be 1: 1-1: 7.
9, a kind of endo-medicine for the treatment of seborrheic alopecia is characterized in that it is the medicament of being made by following component:
Radix Polygoni Multiflori 4-10 gram Radix Salviae Miltiorrhizae 2-5 gram
All-trans-retinoic acid 6-10 milligram
Vitamin B
2The 50-80 milligram
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95103685A CN1051464C (en) | 1994-04-14 | 1995-04-11 | Oral medicine for curing seborrheic baldness |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94112121 | 1994-04-14 | ||
| CN94112121.6 | 1994-04-14 | ||
| CN95103685A CN1051464C (en) | 1994-04-14 | 1995-04-11 | Oral medicine for curing seborrheic baldness |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1114578A true CN1114578A (en) | 1996-01-10 |
| CN1051464C CN1051464C (en) | 2000-04-19 |
Family
ID=25743471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN95103685A Expired - Fee Related CN1051464C (en) | 1994-04-14 | 1995-04-11 | Oral medicine for curing seborrheic baldness |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1051464C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998006412A1 (en) * | 1996-08-09 | 1998-02-19 | Xiaochun Mei | A medicine of external use for treating seborrheic baldness with high efficacy and low side effect and preparation thereof |
| CN104997962A (en) * | 2015-07-16 | 2015-10-28 | 郭飞勇 | Preparation for treating sebrrheic alopecia and preparing method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1087267A (en) * | 1992-11-23 | 1994-06-01 | 梅晓春 | A kind of prescription for the treatment of seborrheic alopecia |
-
1995
- 1995-04-11 CN CN95103685A patent/CN1051464C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998006412A1 (en) * | 1996-08-09 | 1998-02-19 | Xiaochun Mei | A medicine of external use for treating seborrheic baldness with high efficacy and low side effect and preparation thereof |
| CN104997962A (en) * | 2015-07-16 | 2015-10-28 | 郭飞勇 | Preparation for treating sebrrheic alopecia and preparing method thereof |
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| Publication number | Publication date |
|---|---|
| CN1051464C (en) | 2000-04-19 |
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