CN111455557A - Antibacterial nanofiber membrane and preparation method thereof - Google Patents
Antibacterial nanofiber membrane and preparation method thereof Download PDFInfo
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- CN111455557A CN111455557A CN201910050604.XA CN201910050604A CN111455557A CN 111455557 A CN111455557 A CN 111455557A CN 201910050604 A CN201910050604 A CN 201910050604A CN 111455557 A CN111455557 A CN 111455557A
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- antibacterial
- nanofiber membrane
- silver salt
- polylactic acid
- sodium alginate
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- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
- D04H1/54—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by welding together the fibres, e.g. by partially melting or dissolving
- D04H1/56—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by welding together the fibres, e.g. by partially melting or dissolving in association with fibre formation, e.g. immediately following extrusion of staple fibres
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
- D04H1/54—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by welding together the fibres, e.g. by partially melting or dissolving
- D04H1/541—Composite fibres, e.g. sheath-core, sea-island or side-by-side; Mixed fibres
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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Abstract
The invention provides an antibacterial nanofiber membrane obtained based on a solution jet spinning method, wherein fibers of the antibacterial nanofiber membrane comprise silver salt, polyvinyl alcohol, sodium alginate, polylactic acid and a dispersion stabilizer, wherein the mass ratio of the silver salt to the polyvinyl alcohol to the sodium alginate to the polylactic acid to the dispersion stabilizer is as follows: 0.2-0.5: 2-5: 4-7: 15-35: 0.5-1.5. Compared with the traditional electrostatic spinning method, the method has the advantages that the production efficiency is improved by 3-5 times, the operation is simple, and the safety performance of the production process is high; the fiber contains sodium alginate, and when the fiber is contacted with a wound, the fiber can absorb wound exudate, form soft reticular gel on the surface of the wound, provide a moist environment for wound healing, promote wound healing, relieve pain and reduce scar formation; silver salt with antibacterial effect is added, so that silver ions can be uniformly and slowly released, and a lasting antibacterial effect is achieved.
Description
Technical Field
The invention relates to a medical material, in particular to an antibacterial nanofiber membrane.
Background
The antibacterial property of the dressing influences the healing of wounds to a certain extent, and the nanofiber membrane with the antibacterial effect has incomparable advantages such as high specific surface area, porosity and the like as a dressing material, and is one of the current important research directions.
At present, electrostatic spinning is mostly adopted for preparing the nanofiber membrane, and the basic process of electrostatic spinning is as follows: the polymer solution or melt overcomes surface tension under a high-voltage electrostatic field of thousands to tens of thousands of volts to generate a charged jet flow, the solution or melt jet flow is solidified in the jetting process and finally falls on a receiving electrode to form fibers, and a fiber film is formed by a receiving device. The method has the defects of strict equipment requirement, low production efficiency and the like by means of a high-voltage electrostatic field.
Based on this, this application adopts emerging solution to spout the spinning technology production nanofiber membrane, and the principle utilizes high-speed air current to carry out the draft to the solution trickle of being extruded, promotes solvent volatilization simultaneously and makes the trickle solidify and form micro-nanofiber. Compared with the electrostatic spinning technology, the solution jet spinning technology has the advantages of simple process, low energy consumption, high production efficiency and the like.
Disclosure of Invention
The application provides an antibacterial nanofiber membrane and a preparation method thereof, the problem that the production efficiency of the traditional nanofiber membrane prepared by an electrostatic spinning method is low is solved, the safety of the production process is improved, the obtained fiber membrane has good antibacterial performance, sodium alginate is added into a spinning raw material, the fiber membrane has high absorption performance, and when the fiber membrane is in contact with a wound, wound exudate can be absorbed and generates Na together with the exudate+/Ca2+Ion exchange to form soft mesh gel on wound surface, provide moist environment for wound healing, promote formation of prothrombin activator, and accelerate blood circulationCoagulation, promoting wound healing, relieving pain, and reducing scar formation; silver salt with antibacterial effect is added, so that silver ions can be uniformly and slowly released, and a lasting antibacterial effect is achieved.
The technical scheme of the application is as follows:
an antibacterial nanofiber membrane based on a solution jet spinning method is disclosed, wherein fibers of the antibacterial nanofiber membrane comprise silver salt, polyvinyl alcohol, sodium alginate, polylactic acid and a dispersion stabilizer, wherein the mass ratio of the silver salt to the polyvinyl alcohol to the sodium alginate to the polylactic acid to the dispersion stabilizer is 0.2-0.5: 2-5: 4-7: 15-35: 0.5-1.5.
The silver salt has excellent broad-spectrum antibacterial capability and no toxic or side effect on human bodies, and can be widely used as an antibacterial and anti-inflammatory agent. Preferably, the silver salt is one or more of silver nitrate, silver chloride, silver bromide and silver iodide.
Preferably, the dispersion stabilizer is an anionic or nonionic surfactant.
Preferably, the size of the fiber is 200-600 nm.
Preferably, the fiber can be added with an artificially synthesized antibacterial drug, and the artificially synthesized antibacterial drug is Yunnan white drug powder.
A preparation method of an antibacterial nanofiber membrane comprises the following steps:
(1) dissolving polylactic acid and polyvinyl alcohol in a solvent to form a mixed solution;
(2) adding silver salt into the mixed solution, and adding sodium alginate and a dispersion stabilizer under stirring to form a spinning solution;
(3) and carrying out solution jet spinning on the spinning solution, supplying the spinning solution to a spinneret plate through a metering pump, then spraying the spinning solution from the spinneret plate, drafting the sprayed spinning solution trickle under the drafting of high-speed air flow provided by an air compressor, curing through heat radiation, and forming a nanofiber membrane on a receiving device.
Preferably, the wind pressure of the high-speed airflow is 0.1-0.25 MPa.
Preferably, the molecular weight of the polylactic acid is 10000-.
Preferably, the nanofiber membrane has a thickness of 0.1mm to 1 mm.
The prepared antibacterial nanofiber membrane can be used in the field of medical antibacterial.
The beneficial effect of this application lies in:
(1) sodium alginate is added in the application, has high absorption performance, and can absorb wound exudate when contacting with wound, and Na is generated between the wound exudate and the exudate+/Ca2+Ion exchange, namely forming soft reticular gel on the surface of the wound, providing a moist environment for wound healing, promoting the formation of prothrombin activator, accelerating blood coagulation, promoting wound healing, relieving pain and reducing scar formation; silver salt with antibacterial effect is added, so that silver ions can be uniformly and slowly released, and a lasting antibacterial effect is achieved;
(2) compared with the prior electrostatic spinning method, the method has the advantages that the production efficiency is higher, the production efficiency can be improved by 3-5 times, the production process is safe, and potential unsafe factors caused by high voltage are avoided; the fiber size of the nanofiber membrane obtained by the solution jet spinning method is 200-600nm, the nanofiber membrane has a large specific surface area, and the antibacterial effect is improved.
Detailed Description
The invention will be further illustrated with reference to the following specific examples. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. Further, it should be understood that various changes or modifications of the present invention may be made by those skilled in the art after reading the teaching of the present invention, and such equivalents may fall within the scope of the present invention as defined in the appended claims.
Example 1:
a preparation method of an antibacterial nanofiber membrane comprises the following steps:
(1) dissolving polylactic acid and polyvinyl alcohol in a solvent to form a mixed solution;
(2) adding silver salt into the mixed solution, and adding sodium alginate and a dispersion stabilizer under stirring to form a spinning solution;
(3) and carrying out solution jet spinning on the spinning solution, supplying the spinning solution to a spinneret plate through a metering pump, then spraying the spinning solution from the spinneret plate, drafting the sprayed spinning solution trickle under the drafting of high-speed air flow provided by an air compressor, curing through heat radiation, and forming a nanofiber membrane on a receiving device.
The wind pressure of the high-speed airflow is 0.10 MPa.
The molecular weight of the polylactic acid is 10000.
The thickness of the nanofiber membrane was 0.1 mm.
Wherein the mass ratio of the silver salt to the polyvinyl alcohol to the sodium alginate to the polylactic acid to the dispersion stabilizer is 0.2: 2: 4: 15: 0.5.
the silver salt is silver nitrate.
The dispersion stabilizer is sodium dodecyl sulfate and nonylphenol polyoxyethylene ether.
The average size of the fibers was about 400nm as determined by scanning electron microscopy.
The fiber membrane is used in the field of medical antibiosis and is tested for antibiosis performance.
Example 2:
a preparation method of an antibacterial nanofiber membrane comprises the following steps:
(1) dissolving polylactic acid and polyvinyl alcohol in a solvent to form a mixed solution;
(2) adding silver salt into the mixed solution, and adding sodium alginate and a dispersion stabilizer under stirring to form a spinning solution;
(3) and carrying out solution jet spinning on the spinning solution, supplying the spinning solution to a spinneret plate through a metering pump, then spraying the spinning solution from the spinneret plate, drafting the sprayed spinning solution trickle under the drafting of high-speed air flow provided by an air compressor, curing through heat radiation, and forming a nanofiber membrane on a receiving device.
The wind pressure of the high-speed airflow is 0.25 MPa.
The molecular weight of the polylactic acid is 20000.
The thickness of the nanofiber membrane was 1 mm.
Wherein the mass ratio of the silver salt to the polyvinyl alcohol to the sodium alginate to the polylactic acid to the dispersion stabilizer is 0.5: 5: 7: 35: 1.5.
the silver salt is silver chloride.
The dispersion stabilizer is sodium dodecyl benzene sulfonate and octyl phenol polyoxyethylene ether.
The average size of the fibers was about 200nm as determined by scanning electron microscopy.
The fiber membrane is used in the field of medical antibiosis and is tested for antibiosis performance.
Example 3:
a preparation method of an antibacterial nanofiber membrane comprises the following steps:
(1) dissolving polylactic acid and polyvinyl alcohol in a solvent to form a mixed solution;
(2) adding silver salt into the mixed solution, and adding sodium alginate and a dispersion stabilizer under stirring to form a spinning solution;
(3) and carrying out solution jet spinning on the spinning solution, supplying the spinning solution to a spinneret plate through a metering pump, then spraying the spinning solution from the spinneret plate, drafting the sprayed spinning solution trickle under the drafting of high-speed air flow provided by an air compressor, curing through heat radiation, and forming a nanofiber membrane on a receiving device.
The wind pressure of the high-speed airflow is 0.15 MPa.
The molecular weight of the polylactic acid is 15000.
The thickness of the nanofiber membrane was 0.3 mm.
Wherein the mass ratio of the silver salt to the polyvinyl alcohol to the sodium alginate to the polylactic acid to the dispersion stabilizer is 0.4: 3: 5: 20: 1.
the silver salt is silver bromide.
The dispersion stabilizer is sodium dibutylnaphthalenesulfonate and polyoxyethylene lauryl ether.
The average size of the fibers was about 370nm as determined by scanning electron microscopy.
The fiber membrane is used in the field of medical antibiosis and is tested for antibiosis performance.
Example 4:
and (4) evaluating the antibacterial performance of the antibacterial hydrophilic nanofiber membrane, and determining by adopting a shake flask method.
The fiber membranes obtained in examples 1-3 are placed in a centrifuge tube of 50m L, 15m L phosphate buffer solution is added for sterilization, the three membranes are respectively placed in phosphate buffer solution containing staphylococcus aureus (about 105cfu/m L) or candida albicans (about 105cfu/m L), the centrifuge tube is placed in an air shaking table and is shaken for reaction at 37 ℃, a proper amount of culture solution is taken for ten-fold gradient dilution to proper concentration at 4h, 8h, 16h and 24h respectively by adopting a plate colony counting method, then 100 mu L of dilution liquid is taken and dropped on a solid culture medium, the solid culture medium is evenly coated and then placed in a constant temperature and humidity incubator at 37 ℃ for inverted culture, and the colony counting is carried out after 48h, so that the antibacterial activity of the antibacterial membranes is evaluated.
Experimental results show that the fiber membranes of the embodiments 1-3 have good antibacterial activity on staphylococcus aureus and candida albicans, and the bacteriostasis rate can reach more than 98%.
The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, which are made by the present specification, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.
Claims (10)
1. The antibacterial nanofiber membrane is characterized in that fibers of the antibacterial nanofiber membrane comprise silver salt, polyvinyl alcohol, sodium alginate, polylactic acid and a dispersion stabilizer, wherein the mass ratio of the silver salt to the polyvinyl alcohol to the sodium alginate to the polylactic acid to the dispersion stabilizer is 0.2-0.5: 2-5: 4-7: 15-35: 0.5-1.5.
2. The antibacterial nanofiber membrane as claimed in claim 1, wherein the silver salt is one or more of silver nitrate, silver chloride, silver bromide and silver iodide.
3. The antibacterial nanofiber membrane as claimed in claim 1 or 2, wherein the dispersion stabilizer is an anionic or nonionic surfactant.
4. The membrane as claimed in any one of claims 1 to 3, wherein the size of the fibers is 200-600 nm.
5. The antibacterial nanofiber membrane as claimed in any one of claims 1 to 4, wherein an artificially synthesized antibacterial is added to the fibers, and the artificially synthesized antibacterial is Yunnan white drug powder.
6. A method of making the antimicrobial nanofibrous membrane of any of claims 1 to 5, comprising the steps of:
(1) dissolving polylactic acid and polyvinyl alcohol in a solvent to form a mixed solution;
(2) adding silver salt into the mixed solution, and adding sodium alginate and a dispersion stabilizer under stirring to form a spinning solution;
(3) and carrying out solution jet spinning on the spinning solution, supplying the spinning solution to a spinneret plate through a metering pump, then spraying the spinning solution from the spinneret plate, drafting the sprayed spinning solution trickle under the drafting of high-speed air flow provided by an air compressor, curing through heat radiation, and forming a nanofiber membrane on a receiving device.
7. The method of claim 6, wherein the wind pressure of the high-speed air stream is 0.1-0.25 MPa.
8. The method of claim 6 or 7, wherein the molecular weight of the polylactic acid is 10000-.
9. The method of claim 6, wherein the nanofiber membrane has a thickness of 0.1mm to 1 mm.
10. Use of the antibacterial nanofibrous membrane according to any of claims 1 to 5 or obtained by the preparation method according to any of claims 5 to 9 for medical antibacterial applications.
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