CN111450557A

CN111450557A - Evaporation apparatus and evaporation method

Info

Publication number: CN111450557A
Application number: CN202010367486.8A
Authority: CN
Inventors: 陈梦伟; 安广峰; 吕丕平; 李增荣
Original assignee: Shanghai Jiyu Pharmaceutical Technology Co ltd; Jiangxi Jimin Kexin Group Co Ltd
Current assignee: Shanghai Jiyu Pharmaceutical Technology Co ltd; Jiangxi Jimin Kexin Group Co Ltd
Priority date: 2020-04-30
Filing date: 2020-04-30
Publication date: 2020-07-28

Abstract

The present disclosure relates to an evaporation apparatus and an evaporation method. The evaporation device comprises: the evaporator comprises a closed cavity, a feed inlet and an air outlet which are arranged at the top end of the evaporator, a discharge outlet which is arranged at the bottom end of the evaporator, a tower plate which is arranged on the inner wall of the cavity and an air inlet which is arranged below the tower plate, wherein a gap is formed between the tower plate and the inner wall of the cavity; the discharge port of the evaporator is connected with the storage tank; the discharge port of the storage tank is connected with the feed port of the pump, and the discharge port of the pump is connected with the feed port of the evaporator; the air outlet of the evaporator is connected with the air inlet of the condenser. The evaporation device disclosed by the invention can realize the quick separation of volatile solvents in liquid, and the interior of the evaporator is in positive pressure, so that the aseptic control is convenient to realize.

Description

Evaporation apparatus and evaporation method

Technical Field

The present disclosure relates to evaporation apparatuses, and more particularly, to an evaporation apparatus and an evaporation method.

Background

In the preparation of certain substances, such as drugs, an evaporation device is used to separate the volatile solvent from the liquid. Current evaporation devices, such as tanks used for solidification, rely primarily on heat exchange between the tank walls and the liquid to change the temperature of the liquid, causing the solvent to evaporate. The temperature difference between the solution in the center of the tank wall and the tank body is large, the heat transfer is slow, the solvent volatilization speed difference is too large, and the integrity of a sample close to the tank wall is easy to damage.

Disclosure of Invention

The invention aims to provide an evaporation device and an evaporation method, which increase the contact surface and contact time of liquid and gas through a tower plate and realize the quick separation of volatile solvents in the liquid.

One embodiment of the present disclosure provides an evaporation apparatus including: the evaporator comprises a closed cavity, a feed inlet and an air outlet which are arranged at the top end of the evaporator, a discharge outlet which is arranged at the bottom end of the evaporator, a tower plate which is arranged on the inner wall of the cavity and an air inlet which is arranged below the tower plate, wherein a gap is formed between the tower plate and the inner wall of the cavity; the discharge port of the evaporator is connected with the storage tank; the discharge port of the storage tank is connected with the feed port of the pump, and the discharge port of the pump is connected with the feed port of the evaporator; and the air outlet of the evaporator is connected with the air inlet of the condenser. When the evaporation device is used for evaporation, all or most of liquid drops on the tower plate after entering the evaporator cavity from the feed inlet of the evaporator.

According to some embodiments of the disclosure, the evaporation apparatus further comprises: and a condensate outlet of the condenser is connected with the waste liquid tank, and the waste liquid tank is provided with a first temperature control jacket.

According to some embodiments of the disclosure, the evaporation apparatus further comprises: and the exhaust port is arranged between the condenser and the waste liquid tank and used for discharging gas purified by the condenser.

According to some embodiments of the disclosure, a stirring paddle is disposed within the storage tank.

According to some embodiments of the disclosure, a second temperature control jacket is provided on the storage tank.

According to some embodiments of the disclosure, the discharge port of the storage tank is connected to a tank bottom valve, which is connected to the feed port of the pump.

According to some embodiments of the disclosure, the discharge port of the pump is connected to a flow meter, and the flow meter is connected to the feed port of the evaporator.

According to some embodiments of the present disclosure, the width of the tray is greater than 1/2 of the cavity width.

According to some embodiments of the present disclosure, the tower plate is arranged obliquely, and the included angle between the tower plate and the horizontal plane is 0-60 degrees.

According to some embodiments of the present disclosure, the number of the tower plates is multiple, and the multiple tower plates are staggered from top to bottom.

According to some embodiments of the disclosure, the evaporation apparatus further comprises: the tower plate is rotatably arranged on the inner wall of the cavity through a rotating shaft, and the locker is used for locking the tower plate.

An embodiment of the present disclosure provides a method for evaporation using the evaporation apparatus as described above, including: conveying the liquid in the storage tank to the evaporator by the pump, wherein the liquid falls on the tower plate from the feeding hole of the evaporator, flows to the bottom of the evaporator along the tower plate and flows into the storage tank through the discharging hole of the evaporator; feeding gas from a gas inlet of the evaporator, wherein the gas flows upwards in the evaporator and contacts with liquid in the evaporator to take gas volatilized from the liquid away to form mixed gas, and discharging the mixed gas from a gas outlet of the evaporator; and sending the mixed gas into the condenser, and condensing volatilized gas in the mixed gas to form condensate.

The evaporation device according to the embodiment of the disclosure has at least one of the following technical effects: 1) providing a uniform evaporation environment, and accelerating the volatilization speed of the volatile solvent by using the circulating flow of the liquid; 2) gas-liquid equilibrium exchange and volatile gas are taken away through the contact of the gas and the liquid; the evaporation device utilizes positive pressure to accelerate the volatilization speed, and the aseptic control is easy to realize; 3) the liquid spreads on the tower plate, so that the contact area of the liquid and the gas is increased, and the volatilization of the volatile solvent is accelerated; and protects the internal feed liquid components from damage.

Drawings

FIG. 1 is a first schematic diagram of an evaporation apparatus according to an embodiment of the present disclosure;

FIG. 2 is a schematic illustration of a tray according to an embodiment of the disclosure;

FIG. 3 is a schematic view of the present disclosure implementing multiple trays disposed in a cavity;

FIG. 4 is a schematic view of a load binder according to an embodiment of the present disclosure;

FIG. 5 is a schematic view of a third temperature control jacket and gas flow meter according to an embodiment of the disclosure;

FIG. 6 is a second schematic view of an evaporation apparatus according to an embodiment of the present disclosure;

FIG. 7 is a third schematic view of an evaporation apparatus according to an embodiment of the disclosure;

FIG. 8 is a fourth schematic view of an evaporation apparatus of an embodiment of the present disclosure;

FIG. 9 is a fifth schematic view of an evaporation device according to an embodiment of the disclosure;

FIG. 10 is a flow chart of an evaporation method according to an embodiment of the disclosure.

Detailed Description

In the following, only certain exemplary embodiments are briefly described. As those skilled in the art can appreciate, the described embodiments can be modified in various different ways, without departing from the spirit or scope of the present disclosure. Accordingly, the drawings and description are to be regarded as illustrative in nature, and not as restrictive.

In the description of the present disclosure, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "straight", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", and the like, indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed in a particular orientation, and be operated, and therefore should not be considered as limiting the present disclosure. Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, features defined as "first", "second", may explicitly or implicitly include one or more of the described features. In the description of the present disclosure, "a plurality" means two or more unless specifically limited otherwise.

Throughout the description of the present disclosure, it is to be noted that, unless otherwise expressly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection, either mechanically, electrically, or otherwise in communication with one another; either directly or indirectly through intervening media, either internally or in any other relationship. The specific meaning of the above terms in the present disclosure can be understood by those of ordinary skill in the art as appropriate.

In the present disclosure, unless expressly stated or limited otherwise, the first feature "on" or "under" the second feature may comprise the first and second features being in direct contact, or may comprise the first and second features being in contact, not directly, but via another feature in between. Also, the first feature being "on," "above" and "over" the second feature includes the first feature being directly on and obliquely above the second feature, or merely indicating that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature includes the first feature being directly above and obliquely above the second feature, or simply meaning that the first feature is at a lesser level than the second feature.

The following disclosure provides many different embodiments or examples for implementing different features of the disclosure. To simplify the disclosure of the present disclosure, specific example components and arrangements are described below. Of course, they are merely examples and are not intended to limit the present disclosure. Moreover, the present disclosure may repeat reference numerals and/or reference letters in the various examples, which have been repeated for purposes of simplicity and clarity and do not in themselves dictate a relationship between the various embodiments and/or arrangements discussed. In addition, the present disclosure provides examples of various specific processes and materials, but one of ordinary skill in the art may recognize applications of other processes and/or use of other materials.

The preferred embodiments of the present disclosure will be described below with reference to the accompanying drawings, and it should be understood that the preferred embodiments described herein are merely for purposes of illustrating and explaining the present disclosure and are not intended to limit the present disclosure.

As shown in fig. 1, an embodiment of the present disclosure provides an evaporation apparatus. The evaporation apparatus includes an evaporator 1, a storage tank 2, a pump 3, and a condenser 4. The pump 3 is used for conveying the liquid from the storage tank 2 to the evaporator 1, volatile solvent in the liquid, such as low-boiling-point and volatile organic solvent, is volatilized in the evaporator 1, and volatilized gas is condensed into condensate in the condenser 4 for recycling. The liquid in this embodiment is an emulsion or suspension containing a volatile solvent.

The interior of the housing of the evaporator 1 forms a closed cavity 10. The top of the evaporator 1 is provided with a feeding hole 11 for feeding and an air outlet 12 for air outlet, and the bottom of the evaporator 1 is provided with a discharging hole 17 for discharging. A tower plate 13 is arranged in the cavity 10, and the tower plate 13 is arranged on the inner wall of the cavity 10. A gap is formed between the tray 13 and the inner wall of the cavity 10. The number of trays 13 is at least one. The side wall of the evaporator 1 is provided with an air inlet 15, and the air inlet 15 is arranged below the tower plate 13. In the actual evaporation process, liquid flows from top to bottom, gas flows from bottom to top in the evaporator 1, and the gas from bottom to top is in contact with the liquid level to carry out gas-liquid equilibrium exchange to take away the gas volatilized from the liquid. The gas entering the cavity 10 may be selected from nitrogen, compressed air, inert gas, etc.

Part of the edges of the trays 13 are connected to the inner wall of the cavity 10, and the remaining edges form a gap with the inner wall of the cavity 10 not connected to the trays 13, facilitating the flow of liquid and gas. The connection part of the tower plate 13 and the inner wall of the cavity 10 is sealed to avoid liquid leakage. The liquid falls on the tower plate 13 from the feed inlet 11 of the evaporator, and the liquid is spread on the tower plate 13 to form a larger liquid level, so that the contact surface of the liquid and the gas can be increased, the contact time can be prolonged, and the volatilization of the volatile solvent is facilitated. When the evaporator 1 is used for pharmacy, emulsion droplets in the liquid form relatively stable microspheres, and meanwhile, the internal medicine is firmly loaded.

In the embodiment of the present disclosure, as shown in fig. 1, the storage tank 2 is used for storing liquid, and the discharge port 17 of the evaporator 1 is connected to the storage tank 2. In this embodiment, the evaporator 1 is located above the storage tank 2, and the liquid flowing down from the evaporator 1 flows into the storage tank 2.

The pump 3 is used for conveying liquid, the discharge port 24 of the storage tank 2 is connected with the feed port 31 of the pump 3, the discharge port 32 of the pump 3 is connected with the feed port 11 of the evaporator, the pump 3 circulates the liquid in the storage tank 2 to the evaporator 1, the pump 3 in the embodiment adopts a metering pump, the flow rate is adjustable at a constant speed during working, the adjustable range is 0-1000L/h, the metering pump can be a magnetic suspension pump, constant flow can be maintained, and large extrusion, vortex and other effects on the liquid material cannot be generated.

The condenser 4 has a gas pipeline in the middle, and the pipeline can be coiled, U-shaped, snake-shaped and the like for condensing gas. The air inlet 41 of the condenser 4 is connected to the air outlet 12 of the evaporator by a pipe. The mixed gas containing volatilized gas generated by the evaporator 1 enters the condenser 4, and the volatilized gas in the mixed gas is cooled to be condensate and discharged out of the condenser 4 under the action of the condenser 4.

The evaporation device of this embodiment provides a comparatively even evaporation environment, realizes volatilizable solvent's in the liquid quick volatilization, separation to protect inside feed liquid composition not destroyed. The cavity of the evaporation device is kept at positive pressure, so that external air is prevented from entering the cavity to cause pollution, and aseptic control is realized.

As shown in FIG. 2, in this embodiment, the cavity 10 is cylindrical, and the tray 13 is largely semicircular corresponding to the shape of the cavity 10. The curved edge 131 of tray 13 is connected to the inner wall of cavity 10 and the straight edge 132 of tray 13 forms a gap with the inner wall of cavity 10. The liquid flows down through the gap between the tray 13 and the inner wall of the cavity 10. The width B of tray 13 is greater than 1/2 of the width of cavity 10 and less than the width of cavity 10. Optionally, the width B of the tray 13 is 2/3-3/4 of the width of the cavity 10. The tray 13 may be provided in other shapes as needed. It will be understood that the trays are sufficient to contact all or most of the liquid entering the cavity.

In this embodiment, the tray 13 may be made of stainless steel plate, teflon plastic plate, or ceramic plate. The tray 13 should be surface polished and hydrophobic with a surface roughness Ra of less than or equal to 0.4 μm and the edge is ground and smoothed.

In this embodiment, the tray 13 may be disposed horizontally or obliquely. When the tower plate 13 is obliquely arranged, the included angle between the tower plate 13 and the horizontal plane is 0-60 degrees (not including 0 degree). The angle of inclination of the tray 13 is such that the liquid spreads out over the tray 13.

As shown in FIG. 3, according to an alternative embodiment of the present disclosure, the number of the trays 13 is multiple, and the multiple trays 13 are staggered from top to bottom. In this embodiment, the number of trays 13 is four. It will be appreciated that the number of trays 13 can be set by one skilled in the art as desired. The plurality of tower plates 13 are arranged in a staggered manner, so that the corresponding gaps of the adjacent tower plates 13 are positioned on different sides, for example, the corresponding gap of the upper tower plate is positioned on the left side of the cavity 10, and the corresponding gap of the lower tower plate is positioned on the right side of the cavity 10, so that most or all of the liquid flowing down on the upper tower plate is ensured to necessarily flow onto the lower tower plate and spread on the lower tower plate as much as possible. The multi-layer tower plate 13 is more beneficial to increasing the contact surface of liquid and gas and prolonging the contact time, so that the volatile solvent in the liquid can be quickly removed. The edges of the trays 13 forming the gap are arranged as parallel as possible. When the trays 13 are arranged obliquely, the inclination angles of the plurality of trays 13 may be different.

As shown in FIG. 4, according to an alternative embodiment of the present disclosure, the tray 13 is rotatably disposed on the inner wall of the cavity 10 by a rotating shaft 131. The rotating shaft 131 is connected with a locker 18, and the tower plate 13 can be locked by the locker 18 after the tower plate 13 rotates in place. For example, the locking device 18 can be a nut, and is connected with the rotating shaft 131 through threads, the nut is loosened to rotate the tower plate 13, and after the tower plate 13 is rotated to a proper position, the nut is tightened to lock the tower plate 13. The locking device 18 may be other types of mechanisms, such as an existing locking mechanism with a shaft, as required, and can lock the tower plate 13. The tray 13 is rotatable so as to adjust the inclination angle of the tray 13. Different liquids can correspond to different inclination angles of the tower plate 13, so that the evaporator 1 is suitable for treating different liquids.

As shown in fig. 5, optionally, a third temperature control jacket 14 is provided on the side wall of the evaporator 1. The third temperature control jacket 14 is arranged to adjust the temperature in the cavity 10, so as to facilitate the volatilization of the volatile solvent. The adjustable temperature range of the third temperature control jacket 14 is from-20 ℃ to 100 ℃, preferably from 0 to 80 ℃, such as 0 ℃, 10 ℃, 20 ℃, 30 ℃, 40 ℃, 50 ℃, 60 ℃, 70 ℃, 80 ℃.

Optionally, the air tap at the air inlet 15 is connected to the housing of the evaporator 1 through a pagoda head, a gasket, and a clamp, and the sterile air or the air processed by the sterile filter is introduced into the cavity 10 from the air inlet, so that positive pressure is formed in the cavity 10, and the external air is prevented from entering the cavity 10 to cause pollution. The gas flows in the cavity 10 to carry the gas volatilized from the liquid away, so as to form a mixed gas, and the mixed gas is discharged from the gas outlet 12. Optionally, a gas flow meter 16 is connected to the gas inlet 15 for detecting the gas flow rate of the gas inlet 15, so that the gas inlet 15 provides a constant gas flow and provides power for the gas circulation, and the volatilized gas is carried out of the evaporator 1.

As shown in fig. 6, according to an alternative embodiment of the present disclosure, the evaporation apparatus further includes: and a waste liquid tank 6. Optionally, the evaporation apparatus further comprises: and an exhaust port 5. The condensate outlet 42 of the condenser 4 is connected with the waste liquid tank 6, and the condensate generated by the condenser 4 is sent into the waste liquid tank 6 for collection. An exhaust port 5 is provided between the condenser 4 and the waste liquid tank 6. In this embodiment, the vent 5 is provided in a connection pipe between the condenser 4 and the waste liquid tank 6, and the purified gas generated in the condenser is discharged through the vent 5. The bottom of the waste liquid tank 6 is provided with a waste liquid outlet 61, and the waste liquid outlet 61 is provided with a control valve. After the waste liquid tank 6 is fully collected, the waste liquid of the waste liquid tank 6 is discharged through the waste liquid outlet 61. The waste liquid tank 6 is provided with a first temperature control jacket 62 for controlling the temperature in the waste liquid tank 6 and avoiding the waste liquid from being gasified. The adjustable temperature range of the first temperature control jacket 62 is from-20 ℃ to 100 ℃, preferably 0-80 ℃, such as 0 ℃, 10 ℃, 20 ℃, 30 ℃, 40 ℃, 50 ℃, 60 ℃, 70 ℃, 80 ℃.

As shown in fig. 7, according to an alternative embodiment of the present disclosure, a second temperature-controlled jacket 21 is provided on the storage tank 2. The second temperature-control jacket 21 is used to control the temperature of the storage tank 2 so that the liquid in the storage tank 2 is maintained at a temperature favorable for the volatilization of the volatile solvent. The adjustable temperature range of the second temperature-controlling jacket 21 is from-20 ℃ to 100 ℃, preferably from 0 to 80 ℃, such as 0 ℃, 10 ℃, 20 ℃, 30 ℃, 40 ℃, 50 ℃, 60 ℃, 70 ℃ and 80 ℃.

According to an optional technical scheme of the present disclosure, a stirring paddle 22 is arranged in the storage tank 2. The materials in the liquid in the storage tank 2 are uniformly stirred by the stirring paddle 22. The stirring speed of the stirring blade 22 can be adjusted according to the viscosity of the liquid, and the shape of the stirring blade 22 can be frame type or anchor type or fan type or hinge type. The paddles 22 do not produce significant shear on the material.

According to an optional technical scheme of this disclosure, tank bottom valve 23 is connected to holding vessel 2's discharge gate 24, and tank bottom valve 23 connects the feed inlet of pump 3. A tank bottom valve 23 is provided to control the outflow of liquid from the storage tank 2. Alternatively, the initial liquid is fed from the feed inlet of the pump 3 and the liquid is transferred to the storage tank 2 for storage. The liquid with the separated volatile solvent is finally discharged from the tank bottom valve 23 and is conveyed to other equipment, such as a liquid conveying vehicle and the like.

As shown in fig. 8, according to an alternative embodiment of the present disclosure, the discharge port 32 of the pump 3 is connected to the flow meter 7, and the flow meter 7 is connected to the feed port 11 of the evaporator. The flow meter 7 is used for detecting the flow rate of the liquid delivered by the pump 3.

According to an optional technical scheme of the present disclosure, a pressure gauge 8 is arranged on a connecting pipeline between the air outlet 12 of the evaporator and the condenser 4, and is used for detecting the pressure of the mixed gas delivered by the evaporator 1.

As shown in fig. 9, in an alternative scheme, the evaporation device comprises an evaporator 1, a storage tank 2, a pump 3, a condenser 4 and a waste liquid tank 6.

The interior of the housing of the evaporator 1 forms a closed cavity 10. The top of the evaporator 1 is provided with a feeding hole 11 for feeding and an air outlet 12 for air outlet, and the bottom of the evaporator 1 is provided with a discharging hole 17 for discharging. A tower plate 13 is arranged in the cavity 10, and the tower plate 13 is arranged on the inner wall of the cavity 10. A gap is formed between the tray 13 and the inner wall of the cavity 10. The number of trays 13 is at least one. The side wall of the evaporator 1 is provided with an air inlet 15, and the air inlet 15 is arranged below the tower plate 13. In the actual evaporation process, liquid flows from top to bottom, gas flows from bottom to top in the evaporator 1, and the gas from bottom to top is in contact with the liquid level to carry out gas-liquid equilibrium exchange to take away the gas volatilized from the liquid.

Part of the edges of the tray 13 are connected to the inner wall of the cavity 10, and the remaining edges form a gap with the inner wall of the cavity 10 which is not connected to the tray 13, facilitating the flow of liquid and gas. The connection part of the tower plate 13 and the inner wall of the cavity 10 is sealed to avoid liquid leakage. The liquid falls on the tower plate 13 from the feed inlet 11 of the evaporator, and the liquid is spread on the tower plate 13 to form a larger liquid level, so that the contact surface of the liquid and the gas can be increased, the contact time can be prolonged, and the volatilization of the volatile solvent is facilitated. When the evaporator 1 is used for pharmacy, emulsion droplets in the liquid form relatively stable microspheres, and meanwhile, the internal medicine is firmly loaded.

The number of the tower plates 13 can be multiple, and the plurality of tower plates 13 are staggered from top to bottom. In this embodiment, the number of trays 13 is four. It will be appreciated that the number of trays 13 can be set by one skilled in the art as desired. The plurality of tower plates 13 are arranged in a staggered manner, so that the corresponding gaps of the adjacent tower plates 13 are positioned on different sides, for example, the corresponding gap of the upper tower plate is positioned on the left side of the cavity 10, and the corresponding gap of the lower tower plate is positioned on the right side of the cavity 10, so that the liquid flowing down on the upper tower plate is ensured to necessarily flow onto the lower tower plate and spread on the lower tower plate as much as possible.

The side wall of the evaporator 1 is provided with a third temperature control jacket 14. The third temperature control jacket 14 is arranged to adjust the temperature in the cavity 10, so as to facilitate the volatilization of the volatile solvent. The adjustable temperature range of the third temperature control jacket 14 is from-20 ℃ to 100 ℃, preferably from 0 to 80 ℃, such as 0 ℃, 10 ℃, 20 ℃, 30 ℃, 40 ℃, 50 ℃, 60 ℃, 70 ℃, 80 ℃.

The air cock of air inlet 15 department is connected with the casing of evaporimeter 1 through precious tower head, packing ring, clamp, and cavity 10 is let into from the air inlet to aseptic gas or the gas through aseptic filter processing, forms the malleation in the cavity 10, prevents that the outside air from getting into and causing the pollution in the cavity 10. The gas flows in the cavity 10 to carry the gas volatilized from the liquid away, so as to form a mixed gas, and the mixed gas is discharged from the gas outlet 12. Optionally, a gas flow meter 16 is connected to the gas inlet 15 for detecting the gas flow rate of the gas inlet 15, so that the gas inlet 15 provides a constant gas flow and provides power for the gas circulation, and the volatilized gas is carried out of the evaporator 1.

The storage tank 2 is used for storing liquid, and the discharge port 17 of the evaporator 1 is connected with the storage tank 2. In this embodiment, the evaporator 1 is located above the storage tank 2, and the liquid flowing down from the evaporator 1 flows into the storage tank 2.

The storage tank 2 is provided with a second temperature-controlled jacket 21. The second temperature-control jacket 21 is used to control the temperature of the storage tank 2 so that the liquid in the storage tank 2 is maintained at a temperature favorable for the volatilization of the volatile solvent. The adjustable temperature range of the second temperature-controlling jacket 21 is from-20 ℃ to 100 ℃, preferably from 0 to 80 ℃, such as 0 ℃, 10 ℃, 20 ℃, 30 ℃, 40 ℃, 50 ℃, 60 ℃, 70 ℃ and 80 ℃.

The storage tank 2 is provided with a stirring paddle 22. The materials in the liquid in the storage tank 2 are uniformly stirred by the stirring paddle 22. The stirring speed of the stirring blade 22 can be adjusted according to the viscosity of the liquid, and the shape of the stirring blade 22 can be frame type or anchor type or fan type or hinge type. The paddles 22 do not produce significant shear on the material.

The discharge port 24 of the storage tank 2 is connected with the tank bottom valve 23, and the tank bottom valve 23 is connected with the feed port of the pump 3. A tank bottom valve 23 is provided to control the outflow of liquid from the storage tank 2. Alternatively, the initial liquid is fed from the feed inlet of the pump 3 and the liquid is transferred to the storage tank 2 for storage. The liquid with the separated volatile solvent is finally discharged from the tank bottom valve 23 and is conveyed to other equipment, such as a liquid conveying vehicle and the like.

The discharge port 32 of the pump 3 is connected with the flow meter 7, and the flow meter 7 is connected with the feed port 11 of the evaporator. The flow meter 7 is used for detecting the flow rate of the liquid delivered by the pump 3.

A pressure gauge 8 is arranged on a connecting pipeline between the air outlet 12 of the evaporator and the condenser 4 and is used for detecting the pressure of the mixed gas delivered by the evaporator 1.

The condensate outlet 42 of the condenser 4 is connected with the waste liquid tank 6, and the condensate generated by the condenser 4 is sent into the waste liquid tank 6 for collection. An exhaust port 5 is provided between the condenser 4 and the waste liquid tank 6. In this embodiment, the vent 5 is provided in a connection pipe between the condenser 4 and the waste liquid tank 6, and the purified gas generated in the condenser is discharged through the vent 5. The bottom of the waste liquid tank 6 is provided with a waste liquid outlet 61, and the waste liquid outlet 61 is provided with a control valve. After the waste liquid tank 6 is fully collected, the waste liquid of the waste liquid tank 6 is discharged through the waste liquid outlet 61. The waste liquid tank 6 is provided with a first temperature control jacket 62 for controlling the temperature in the waste liquid tank 6 and avoiding the waste liquid from being gasified. The adjustable temperature range of the first temperature control jacket 62 is from-20 ℃ to 100 ℃, preferably 0-80 ℃, such as 0 ℃, 10 ℃, 20 ℃, 30 ℃, 40 ℃, 50 ℃, 60 ℃, 70 ℃, 80 ℃.

As shown in fig. 10, one embodiment of the present disclosure provides a method of evaporation using the evaporation apparatus as above, including:

s1010, conveying the liquid in the storage tank to an evaporator by a pump, enabling the liquid to fall on a tower plate from a feed inlet of the evaporator, flow to the bottom of the evaporator along the tower plate, and flow into the storage tank through a discharge outlet of the evaporator.

And S1020, feeding gas into the evaporator through a gas inlet of the evaporator, enabling the gas to flow upwards in the evaporator and contact with liquid in the evaporator, taking away gas volatilized from the liquid, forming mixed gas, and discharging the mixed gas from a gas outlet of the evaporator.

And S1030, feeding the mixed gas into a condenser, and condensing volatilized gas in the mixed gas to form condensate. The condensate is discharged from the condenser.

The evaporation device and the evaporation method of the embodiment are suitable for removing volatile solvents in liquid. Such as an emulsion with a small or large molecule drug (protein, etc.) loaded inside, or a suspension of microspheres, or a suspension of microparticles, optionally with microparticles having a particle size of 50nm to 500 μm.

Alternatively, the evaporation apparatus and the evaporation method of the present embodiment are suitable for a two-phase mixed solution of an organic reagent with a low boiling point and a relatively high volatility and water, such as a two-phase mixed solution of water and an organic reagent such as methanol, ethanol, dichloromethane, chloroform, n-heptane, and the like.

Optionally, the evaporation device and the evaporation method of the embodiment are suitable for drug loading and fixing of drug carrying systems such as microspheres and nanoparticles of various sizes of molecular drugs.

Taking the example of treating a suspension of water and dichloromethane by the evaporation apparatus of the present disclosure, the process flow is:

1. the second temperature control jacket 21 of the storage tank 2 is opened, the temperature is set to 30 ℃, and the temperature in the second temperature control jacket is fully balanced with the set temperature value.

2. The suspension of water and dichloromethane was slowly added to the feed inlet 11 of the evaporator through the feed inlet 31 of the pump 3, and the suspension of water and dichloromethane slowly flowed through all the trays through the tray 13 and into the storage tank 2.

3. After all the suspension is added, the pump 3 is turned off and the inlet 31 is connected to the outlet 24 of the storage tank 2. The stirring paddle 22 and the pump 3 in the storage tank 2 are turned on, so that the suspension of water and dichloromethane can be uniformly circulated in the evaporator 1. The third temperature control jacket 14 was opened as needed and set to a temperature of 30 ℃.

4. And introducing gas into the evaporator 1 to evaporate the dichloromethane in the suspension, sending the mixed gas into the condenser 4 for treatment, and condensing the dichloromethane in the mixed gas into liquid.

5. When the evaporation of dichloromethane was completed, the second temperature-controlled jacket 21, the paddle 22 in the storage tank 2 and the pump 3 were closed. The discharge port 24 of the storage tank 2 is opened, and the final feed liquid is transferred to the corresponding tank for storage and standby.

Finally, it should be noted that: although the present disclosure has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the disclosure. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present disclosure should be included in the protection scope of the present disclosure.

Claims

1. An evaporation apparatus, comprising:

the evaporator comprises a closed cavity, a feed inlet and an air outlet which are arranged at the top end of the evaporator, a discharge outlet which is arranged at the bottom end of the evaporator, a tower plate which is arranged on the inner wall of the cavity and an air inlet which is arranged below the tower plate, wherein a gap is formed between the tower plate and the inner wall of the cavity;

the discharge port of the evaporator is connected with the storage tank;

the discharge port of the storage tank is connected with the feed port of the pump, and the discharge port of the pump is connected with the feed port of the evaporator;

and the air outlet of the evaporator is connected with the air inlet of the condenser.

2. The vaporizing device of claim 1 further comprising:

a condensate outlet of the condenser is connected with the waste liquid tank, and a first temperature control jacket is arranged on the waste liquid tank;

optionally, the evaporation apparatus further comprises: and the exhaust port is arranged between the condenser and the waste liquid tank and used for discharging gas purified by the condenser.

3. The evaporation apparatus as claimed in claim 1, wherein a stirring paddle is disposed in the storage tank;

optionally, a second temperature-controlled jacket is provided on the storage tank.

4. The evaporation apparatus as claimed in claim 1, wherein the outlet of the storage tank is connected to a tank bottom valve, and the tank bottom valve is connected to the inlet of the pump.

5. The evaporation apparatus as claimed in claim 1, wherein the outlet of the pump is connected to a flow meter, and the flow meter is connected to the inlet of the evaporator.

6. The evaporation apparatus of claim 1, wherein the tray has a width greater than 1/2 of the cavity width.

7. The evaporation device as claimed in claim 1, wherein the tower plate is disposed obliquely, and the included angle between the tower plate and the horizontal plane is 0-60 °.

8. The evaporation apparatus as claimed in claim 1, wherein the number of said trays is plural, and a plurality of said trays are staggered from top to bottom.

9. The vaporizing device of claim 1 further comprising: the tower plate is rotatably arranged on the inner wall of the cavity through a rotating shaft, and the locker is used for locking the tower plate.

10. A method of evaporation using the evaporation apparatus of any one of claims 1 to 9, comprising:

conveying the liquid in the storage tank to the evaporator by the pump, wherein the liquid falls on the tower plate from the feeding hole of the evaporator, flows to the bottom of the evaporator along the tower plate and flows into the storage tank through the discharging hole of the evaporator;

feeding gas from a gas inlet of the evaporator, wherein the gas flows upwards in the evaporator and contacts with liquid in the evaporator to take gas volatilized from the liquid away to form mixed gas, and discharging the mixed gas from a gas outlet of the evaporator;

and sending the mixed gas into the condenser, and condensing volatilized gas in the mixed gas to form condensate.