CN111435107A - Biological tissue slicer - Google Patents
Biological tissue slicer Download PDFInfo
- Publication number
- CN111435107A CN111435107A CN201910027725.2A CN201910027725A CN111435107A CN 111435107 A CN111435107 A CN 111435107A CN 201910027725 A CN201910027725 A CN 201910027725A CN 111435107 A CN111435107 A CN 111435107A
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- base
- servo motor
- water
- electric telescopic
- dyeing
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- 238000004043 dyeing Methods 0.000 claims abstract description 21
- 239000002994 raw material Substances 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 50
- 239000002699 waste material Substances 0.000 claims description 12
- 239000011521 glass Substances 0.000 claims description 8
- 239000012188 paraffin wax Substances 0.000 claims description 7
- 238000005086 pumping Methods 0.000 claims description 4
- 230000001681 protective effect Effects 0.000 claims description 3
- 238000013016 damping Methods 0.000 claims description 2
- 238000010186 staining Methods 0.000 claims 2
- 238000000034 method Methods 0.000 description 3
- 238000011160 research Methods 0.000 description 2
- 238000005096 rolling process Methods 0.000 description 2
- 238000013459 approach Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
- G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention discloses a biological tissue slicer, which comprises a base, wherein the base is fixedly arranged on the ground, the base is provided with a containing mechanism, one side of the containing mechanism is provided with a crank block mechanism, one side of the containing mechanism is provided with a slicing mechanism, one side of the slicing mechanism is provided with a dyeing mechanism, one side of the dyeing mechanism is provided with a placing mechanism, the base is provided with a warning mechanism, one side of the upper surface of the base is provided with a controller, the device is automatically controlled by a controller, a user places the raw materials on the containing mechanism, the raw materials are driven by the crank slide block mechanism to circularly reciprocate and are sliced by the slicing mechanism, by this device automatic with the garbage collection back of excision, with the thin slice excision of needs and collect and dye, put it after dyeing finishes, do not accomplish once work after, send out the police dispatch newspaper by warning mechanism and remind. The invention has the advantages of simple structure and strong practicability.
Description
Technical Field
The invention relates to the field of medical equipment, in particular to a biological tissue microtome.
Background
In order to facilitate the study of biological tissues, it is necessary to embed the biological tissues in paraffin, and after they are solidified, they are sectioned in order and placed under a microscope for observation.
General biological tissue slicer for example patent number is CN201521107111, the patent name is a biological tissue slicer's patent, it passes through the objective table and connects the telescopic link, the angle through the flexible adjustable objective table of telescopic link, more make things convenient for the completion of cutting work, knife rest angle adjustable, it is more convenient to make the use of slicer, the blade group is equipped with the blade of a plurality of cutter adjustable, no longer need the cutting of a slice when the cutting, can once only cut down the multi-disc, make more accurate of cutting, the cutting bed advances or retreats by motor control, but accurate location, make the going on of section work ability more smoothly.
However, there are some problems in using it, which only has a slicing function, and in practical research, the cut object needs to be placed on a glass slide, and observation and research are performed under a microscope after dyeing, and these works generally need to be completed manually by workers, which affects the working efficiency.
Disclosure of Invention
The invention aims to solve the problems and designs a biological tissue microtome.
The technical scheme of the invention is that the biological tissue microtome comprises a base, the base is fixedly arranged on the ground, a containing mechanism is arranged on the base, a crank block mechanism is arranged on one side of the containing mechanism, a slicing mechanism is arranged on one side of the containing mechanism, a dyeing mechanism is arranged on one side of the slicing mechanism, a placing mechanism is arranged on one side of the dyeing mechanism, a warning mechanism is arranged on the base, a controller is arranged on one side of the upper surface of the base, the device is automatically controlled by a controller, a user places the raw materials on the containing mechanism, the raw materials are driven by the crank slide block mechanism to circularly reciprocate and are sliced by the slicing mechanism, by this device automatic with the garbage collection back of excision, with the thin slice excision of needs and collect and dye, put it after dyeing finishes, do not accomplish once work after, send out the police dispatch newspaper by warning mechanism and remind.
Hold mechanism and include two spouts of fixed mounting in base upper surface one side, be equipped with the movable block between two spouts, movable block lower surface both sides are equipped with the slider, the slider lower extreme is located the spout respectively, the movable block upper surface is equipped with square through groove, square through groove inner surface is equipped with a plurality of draw-in grooves, square through groove is interior to have placed and to hold the mould, it is equipped with a plurality of buckles to hold the mould lower surface, the buckle is connected with the draw-in groove one-to-one, biological tissue paraffin piece has been placed in holding the mould, movable block upper surface both sides are equipped with first electric telescopic handle, first electric telescopic handle is located square through groove both sides, the movable block top is equipped with the type baffle, type baffle handstand is placed, type baffle overhang stretches into square through groove, type baffle upper end and first electric telescopic handle telescopic.
The slider-crank mechanism includes the fixed station of fixed mounting in spout rear one side, and the fixed station upper surface is equipped with the rotating electrical machines, and the rotatory end of rotating electrical machines is equipped with the rolling disc, and the rolling disc lower extreme is equipped with the fixed axle, and movable block upper surface one side is equipped with the connection platform, and the fixed axle end is equipped with fixing bearing with the connection platform upper surface, and two fixing bearing are as high as the rotating electrical machines rotation end, and fixing bearing one side is equipped with shape connecting rod, and shape connecting rod both ends insert respectively in the corresponding fixing bearing.
The slicing mechanism comprises a cutting knife rest fixedly mounted on one side of the front of a moving block, a circular groove is formed in one side of the cutting knife rest, a first servo motor is arranged on the inner lower surface of the circular groove, a containing disc is arranged at the rotating end of the first servo motor, a plurality of supporting wheels are arranged on the lower surface of the containing disc, a waste containing box is arranged on one side of the upper surface of the containing disc, a second electric telescopic rod is arranged at the upper end of the front side surface of the cutting knife rest, a scraper blade is arranged at the lower end of the telescopic end of the second electric telescopic rod.
Dyeing mechanism includes fixed mounting and holds the flourishing water box of dish upper surface, be equipped with the mechanism that flows on the flourishing water box, flourishing water box one side is equipped with the dyeing box, it puts and is equipped with second servo motor to hold dish upper surface central point, second servo motor rotation end is equipped with the bracing piece, upper end of the support bar one side is equipped with third servo motor, third servo motor rotation end one side is equipped with third electric telescopic handle, the flexible end of third electric telescopic handle is equipped with fourth servo motor, fourth servo motor rotation end one side is equipped with fourth electric telescopic handle, the flexible end lower surface of fourth electric telescopic handle is equipped with second vacuum chuck, second vacuum chuck one side is equipped with infrared range finder, dyeing box one side is equipped with the slide and holds the box, be equipped with the recess that the corresponding position of dish was held in the flash on cutting knife platform and the.
The flow mechanism comprises a small-sized water pump fixedly installed on one side of the water containing box, a water outlet is formed in one side of the lower end of the water containing box, a water pumping pipe and the small-sized water pump are fixedly connected at the water outlet, a water inlet is formed in the other side of the lower end of the water containing box, a water inlet pipe and the small-sized water pump are fixedly connected at the water inlet, and check valves are arranged in the water pumping pipe and the water inlet pipe.
The placing mechanism comprises a placing table fixedly installed on one side of the containing disc, a plurality of placing grooves are formed in the placing table, damping pads are arranged on the inner lower surfaces of the placing grooves, and a blower is arranged on one side of the placing table.
The warning mechanism comprises an infrared detector fixedly mounted on the upper surface of the placing table, the infrared detector is located at the tail end of the placing groove, and a warning lamp is arranged on one side of the infrared detector.
The biological tissue slicer manufactured by the technical scheme of the invention can automatically collect the cut waste materials additionally, automatically place the slices to be researched in water to be flat, use the glass slide to flatly hold the slices out through mechanical equipment and dye the slices, automatically place the slices on one side after dyeing is finished, and automatically alarm and remind workers after a group of works are finished, thereby greatly reducing the labor capacity of the workers and improving the working efficiency.
Drawings
FIG. 1 is a schematic view of a microtome according to the present invention;
FIG. 2 is a partial schematic view of the holding mechanism of the present invention;
FIG. 3 is a partial schematic view of the dyeing mechanism of the present invention;
FIG. 4 is an enlarged view of a portion of the dyeing mechanism of the present invention;
FIG. 5 is an enlarged view of a portion of the flow mechanism of the present invention;
FIG. 6 is an enlarged view of a portion of the warning mechanism of the present invention;
in the drawing, the device comprises a base 1, a controller 2, a sliding groove 3, a sliding groove 4, a moving block 5, a sliding block 6, a square through groove 7, a clamping groove 8, a containing mold 9, a buckle 10, a first electric telescopic rod 11, a convex baffle plate 12, a first vacuum suction cup 13, a fixed table 14, a rotating motor 15, a rotating disc 16, a fixed shaft 17, a connecting table 18, a fixed bearing 19, -shaped connecting rod 20, a cutting knife table 21, a circular groove 22, a first servo motor 23, a containing disc 24, a supporting wheel 25, a waste containing box 26, a second electric telescopic rod 27, a scraping plate 28, a protective pad 29, a water containing box 30, a dyeing box 31, a second servo motor 31, a support rod 32, a support rod 33, a third servo motor 34, a third electric telescopic rod 35, a fourth servo motor 36, a fourth electric telescopic rod 37, a second vacuum suction cup 38, an infrared ray range finder 39, a glass carrying groove 40, a small-mounted water pump 44, a small-suction cup 44, a small-type water pump 44, a small-suction cup 48, a small-type water-sucking cup 48, a small-suction cup 48, a small-type suction.
Detailed Description
The invention is described in detail below with reference to the drawings, which are shown in fig. 1-6.
In the embodiment, in the first step, slicing is carried out, wherein a user places a containing mold 8 containing a biological tissue paraffin block in a square through groove 6 and fixes the mold through the matching of a buckle 9 and a clamping groove 7, a controller 2 controls a first electric telescopic rod 10 to be started to be shortened, a first vacuum suction cup 12 is made to be close to the containing mold 8, the first vacuum suction cup 12 is started to suck the biological tissue paraffin block, the first electric telescopic rod 10 is lengthened or shortened to control the feeding of the biological tissue paraffin block, the controller 2 controls a rotary motor 14 to be started to rotate, a rotating disc 15, a fixed shaft 16, two fixed bearings 18, an -shaped connecting rod 19 and a connecting table 17 form a crank-slider mechanism, the fixed shaft 16 is driven to rotate through the rotary motor 14 so that a moving block 4 can carry out reciprocating movement and can carry out cutting through a cutting knife table 20, and in the process, the biological tissue paraffin block can be adjusted according to actual needs to be cut and is convenient to use;
secondly, collecting waste materials; when slicing is carried out, the waste at the front end needs to be cut off, the controller 2 controls to start the first servo motor 22, the holding disc 23 is driven to rotate by the first servo motor, the waste holding box 25 is rotated into the groove 40 below the cutting knife platform 20, the first electric telescopic rod 10 is started to shorten, the rotating motor 14 is started to cut, the waste is cut off, the controller 2 controls to start the second electric telescopic rod 26 to extend or shorten, the waste on the front side surface of the cutting knife platform 20 is cleaned up through the scraper 27 and the protective pad 28 and is collected into the waste holding box 25, and in the process, the device can automatically clean the waste, does not need manual participation and is safer to use;
thirdly, collecting slices: the controller 2 controls the second servo motor 31, the third servo motor 33 and the fourth servo motor 35 to rotate, the third electric telescopic rod 34 and the fourth electric telescopic rod 36 are started to extend or shorten, the second vacuum suction cup 37 is moved to the position above a glass slide containing box 39, the infrared distance meter 38 measures the distance, the second vacuum suction cup 37 is started to suck one end of the glass slide, the second servo motor 31, the third servo motor 33 and the fourth servo motor 35 are started to rotate, the third electric telescopic rod 34 and the fourth electric telescopic rod 36 are started to extend or shorten to obliquely place the glass slide into one side of the water containing box 29, the first servo motor 22 is started to drive the water containing plate 23 to rotate, the water containing box 29 is rotated into a groove 40 below the cutting knife platform 20, then the material is cut, the cut slices fall into the water under the action of gravity and are spread, the small water pump 41 is started, the water in the water containing box 29 is driven by the water storage device to flow, so that the slices approach to the glass slide, after a period of time, the second servo motor 31, the third servo motor 33 and the fourth servo motor 35 are started to rotate, the third electric telescopic rod 34 and the fourth electric telescopic rod 36 are started to extend or shorten and then are placed in the dyeing box 30 for dyeing, the slices are moved to the position above the placing groove 48 and placed in the placing groove, the blower 50 is started to blow the slices for drying, and in the process, the device can automatically level, dye, collect and place the slices, so that the time is saved, and the efficiency is improved;
step four, warning: whether an article is placed in the last position placing groove 48 is detected by an infrared detector 51, and after the article is placed in the last position placing groove, a warning lamp 52 is started to remind.
The technical solutions described above only represent the preferred technical solutions of the present invention, and some possible modifications to some parts of the technical solutions by those skilled in the art all represent the principles of the present invention, and fall within the protection scope of the present invention.
Claims (8)
1. A biological tissue slicer comprises a base (1) and is characterized in that the base (1) is fixedly arranged on the ground, a containing mechanism is arranged on the base (1), a slider-crank mechanism is arranged on one side of the containing mechanism, a slicing mechanism is arranged on one side of the containing mechanism, a dyeing mechanism is arranged on one side of the slicing mechanism, a placing mechanism is arranged on one side of the dyeing mechanism, a warning mechanism is arranged on the base (1), a controller (2) is arranged on one side of the upper surface of the base (1), the device is automatically controlled by the controller (2), a user places raw materials on the containing mechanism, the raw materials are driven to circularly reciprocate by the slider-crank mechanism and slice the raw materials by using the slicing mechanism, required thin slices are cut and collected for dyeing after the cut waste materials are automatically collected by the device, the thin slices are placed after dyeing is finished, and after one-time work is not finished, the warning mechanism sends out an alarm to remind.
2. The biological tissue microtome according to claim 1, wherein the holding mechanism comprises two sliding grooves (3) fixedly installed on one side of the upper surface of the base (1), a moving block (4) is arranged between the two sliding grooves (3), sliding blocks (5) are arranged on two sides of the lower surface of the moving block (4), the lower ends of the sliding blocks (5) are respectively located in the sliding grooves (3), a square through groove (6) is arranged on the upper surface of the moving block (4), a plurality of clamping grooves (7) are arranged on the inner lower surface of the square through groove (6), a holding mold (8) is arranged in the square through groove (6), a plurality of buckles (9) are arranged on the lower surface of the holding mold (8), the buckles (9) are connected with the clamping grooves (7) in a one-to-one correspondence manner, paraffin blocks of biological tissues are arranged in the holding mold (8), first electric telescopic rods (10) are arranged on two sides of the upper surface of, a convex baffle (11) is arranged above the moving block (4), the convex baffle (11) is placed in an inverted mode, the protruding end of the convex baffle (11) extends into the square through groove (6), the upper end of the convex baffle (11) is fixedly connected with the telescopic end of the first electric telescopic rod (10), and a first vacuum sucker (12) is arranged on the inner side of the lower end of the convex baffle (11).
3. The microtome according to claim 1, wherein the slider-crank mechanism comprises a fixed base (13) fixedly mounted on one side of the rear of the chute (3), a rotating motor (14) is disposed on the upper surface of the fixed base (13), a rotating disc (15) is disposed at the rotating end of the rotating motor (14), a fixed shaft (16) is disposed at the lower end of the rotating disc (15), a connecting base (17) is disposed on one side of the upper surface of the moving block (4), fixed bearings (18) are disposed at the ends of the fixed shaft (16) and the upper surface of the connecting base (17), two fixed bearings (18) have the same height as the rotating end of the rotating motor (14), -shaped connecting rods (19) are disposed on one side of the fixed bearings (18), and two ends of the -shaped connecting rods (19) are respectively inserted into the corresponding.
4. The microtome according to claim 1, wherein the microtome mechanism comprises a cutting knife platform (20) fixedly mounted on one side in front of the moving block (4), a circular groove (21) is formed on one side of the cutting knife platform (20), a first servo motor (22) is arranged on the inner lower surface of the circular groove (21), a holding disc (23) is arranged at the rotating end of the first servo motor (22), a plurality of supporting wheels (24) are arranged on the lower surface of the holding disc (23), a waste holding box (25) is arranged on one side of the upper surface of the holding disc (23), a second electric telescopic rod (26) is arranged at the upper end of the front side surface of the cutting knife platform (20), a scraper (27) is arranged at the lower end of the telescopic end of the second electric telescopic rod (26), and a protective pad (28) is arranged on the inner side surface of the.
5. The microtome according to claim 1, wherein the staining mechanism comprises a water containing box (29) fixedly mounted on the upper surface of the water containing plate (23), a flowing mechanism is arranged on the water containing box (29), a staining box (30) is arranged on one side of the water containing box (29), a second servo motor (31) is arranged at the center of the upper surface of the water containing plate (23), a support rod (32) is arranged at the rotating end of the second servo motor (31), a third servo motor (33) is arranged on one side of the upper end of the support rod (32), a third electric telescopic rod (34) is arranged on one side of the rotating end of the third servo motor (33), a fourth servo motor (35) is arranged at the end of the telescopic end of the third electric telescopic rod (34), a fourth electric telescopic rod (36) is arranged on one side of the rotating end of the fourth servo motor (35), and a second vacuum suction cup (37) is arranged on the lower surface of the telescopic end of the fourth, an infrared distance meter (38) is arranged on one side of the second vacuum chuck (37), a glass slide containing box (39) is arranged on one side of the dyeing box (30), and grooves (40) which flash out of corresponding positions of the containing disc (23) are arranged on the cutting knife table (20) and the moving block (4).
6. The microtome according to claim 5, wherein the flow mechanism comprises a small water pump (41) fixedly mounted on one side of the water containing box (29), a water outlet (42) is provided on one side of the lower end of the water containing box (29), a water pumping pipe (43) is provided at the water outlet (42) and fixedly connected with the water inlet end of the small water pump (41), a water inlet (44) is provided at the other side of the lower end of the water containing box (29), a water inlet pipe (45) is provided at the water inlet (44) and fixedly connected with the water outlet end of the small water pump (41), and a check valve (46) is provided in each of the water pumping pipe (43) and the water inlet pipe (45).
7. The microtome according to claim 1, wherein the placing mechanism comprises a placing table (47) fixedly mounted on one side of the holding tray (23), a plurality of placing grooves (48) are formed in the placing table (47), vibration-damping pads (49) are arranged on the inner and lower surfaces of the placing grooves (48), and a blower (50) is arranged on one side of the placing table (47).
8. The microtome according to claim 1, wherein the warning means comprises an infrared detector (51) fixedly mounted on the upper surface of the placing table (47), the infrared detector being located on the side of the placing recess (48) at the distal end, and a warning lamp (52) being provided on the side of the infrared detector (51).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910027725.2A CN111435107A (en) | 2019-01-11 | 2019-01-11 | Biological tissue slicer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910027725.2A CN111435107A (en) | 2019-01-11 | 2019-01-11 | Biological tissue slicer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111435107A true CN111435107A (en) | 2020-07-21 |
Family
ID=71579799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910027725.2A Pending CN111435107A (en) | 2019-01-11 | 2019-01-11 | Biological tissue slicer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111435107A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114311057A (en) * | 2021-12-27 | 2022-04-12 | 中国科学技术大学 | Automatic device for vibration slicing and collection of oversized sample |
| CN117890183A (en) * | 2024-03-14 | 2024-04-16 | 济南中仁谊科医学检验实验室有限公司 | Paraffin section processing device |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1240548A (en) * | 1968-07-24 | 1971-07-28 | Ronald Leslie Bishton | Method and apparatus for histological study |
| CN1650159A (en) * | 2002-04-26 | 2005-08-03 | 万堂医药系统公司 | Automated molecular pathology apparatus having fixed slide platforms |
| US7374907B1 (en) * | 2000-04-07 | 2008-05-20 | John Voneiff | System and method for automatically processing tissue samples |
| CN202547988U (en) * | 2012-02-24 | 2012-11-21 | 奚金华 | Fully automatic pathological tissue slicing system |
| CN206300822U (en) * | 2016-12-08 | 2017-07-04 | 上海市动物疫病预防控制中心 | A kind of tissue treatment and automatic staining dual-purpose integrated machine |
| CN106979878A (en) * | 2017-05-09 | 2017-07-25 | 南昌德漫多科技有限公司 | A kind of histopathology sample processing system |
-
2019
- 2019-01-11 CN CN201910027725.2A patent/CN111435107A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1240548A (en) * | 1968-07-24 | 1971-07-28 | Ronald Leslie Bishton | Method and apparatus for histological study |
| US7374907B1 (en) * | 2000-04-07 | 2008-05-20 | John Voneiff | System and method for automatically processing tissue samples |
| CN1650159A (en) * | 2002-04-26 | 2005-08-03 | 万堂医药系统公司 | Automated molecular pathology apparatus having fixed slide platforms |
| CN202547988U (en) * | 2012-02-24 | 2012-11-21 | 奚金华 | Fully automatic pathological tissue slicing system |
| CN206300822U (en) * | 2016-12-08 | 2017-07-04 | 上海市动物疫病预防控制中心 | A kind of tissue treatment and automatic staining dual-purpose integrated machine |
| CN106979878A (en) * | 2017-05-09 | 2017-07-25 | 南昌德漫多科技有限公司 | A kind of histopathology sample processing system |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114311057A (en) * | 2021-12-27 | 2022-04-12 | 中国科学技术大学 | Automatic device for vibration slicing and collection of oversized sample |
| CN114311057B (en) * | 2021-12-27 | 2022-12-23 | 中国科学技术大学 | Automatic device for vibration slicing and collection of oversized sample |
| CN117890183A (en) * | 2024-03-14 | 2024-04-16 | 济南中仁谊科医学检验实验室有限公司 | Paraffin section processing device |
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Application publication date: 20200721 |
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