CN111420065A - Mixed glue composition and preparation method thereof - Google Patents
Mixed glue composition and preparation method thereof Download PDFInfo
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- CN111420065A CN111420065A CN202010386297.5A CN202010386297A CN111420065A CN 111420065 A CN111420065 A CN 111420065A CN 202010386297 A CN202010386297 A CN 202010386297A CN 111420065 A CN111420065 A CN 111420065A
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- glycerol
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- 239000003292 glue Substances 0.000 title claims abstract description 53
- 239000000203 mixture Substances 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 74
- 108010010803 Gelatin Proteins 0.000 claims abstract description 33
- 239000008273 gelatin Substances 0.000 claims abstract description 33
- 229920000159 gelatin Polymers 0.000 claims abstract description 33
- 235000019322 gelatine Nutrition 0.000 claims abstract description 33
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000008213 purified water Substances 0.000 claims abstract description 17
- 229920002472 Starch Polymers 0.000 claims abstract description 16
- 239000008107 starch Substances 0.000 claims abstract description 16
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 15
- 235000019698 starch Nutrition 0.000 claims abstract description 15
- 239000003765 sweetening agent Substances 0.000 claims abstract description 15
- 239000002994 raw material Substances 0.000 claims abstract description 10
- 238000010411 cooking Methods 0.000 claims abstract description 9
- 238000010438 heat treatment Methods 0.000 claims abstract description 9
- 238000002156 mixing Methods 0.000 claims abstract description 5
- 238000003756 stirring Methods 0.000 claims description 20
- 238000004321 preservation Methods 0.000 claims description 16
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 14
- 239000000600 sorbitol Substances 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 10
- 238000002844 melting Methods 0.000 claims description 8
- 230000008018 melting Effects 0.000 claims description 8
- 239000000499 gel Substances 0.000 claims description 5
- 238000009835 boiling Methods 0.000 claims description 4
- 239000004014 plasticizer Substances 0.000 claims description 2
- 238000011031 large-scale manufacturing process Methods 0.000 abstract description 2
- 235000011187 glycerol Nutrition 0.000 description 20
- 238000005457 optimization Methods 0.000 description 14
- 239000007788 liquid Substances 0.000 description 9
- 239000002775 capsule Substances 0.000 description 7
- 230000009965 odorless effect Effects 0.000 description 6
- 239000007901 soft capsule Substances 0.000 description 6
- 239000000843 powder Substances 0.000 description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 2
- 239000007902 hard capsule Substances 0.000 description 2
- 239000002861 polymer material Substances 0.000 description 2
- 230000009967 tasteless effect Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000005485 electric heating Methods 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000001223 reverse osmosis Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Jellies, Jams, And Syrups (AREA)
Abstract
The invention discloses a mixed glue composition, which comprises the following components in parts by weight: 8.0-9.4KG of glycerol, 17.5-19.8KG of purified water, 10.0-12.0KG of animal gelatin, 9.0-11.5KG of starch and 0.5-1.3KG of sweetener. The novel mixed glue is obtained by mixing, heating, cooking and vacuumizing raw materials, the technical scheme can solve the problems of peculiar smell and odor of the gelatin in the prior art, and the gelatin has extremely high safety and low raw material cost in a raw material formula, has a large-scale production value and has higher practicability.
Description
Technical Field
The invention relates to a preparation method of a mixed glue composition material, in particular to a mixed glue composition for preparing soft capsules, hard capsules and chewable soft capsules by replacing gelatin and a preparation method thereof, and belongs to the field of biological pharmacy.
Background
The soft capsule is prepared by processing liquid medicine or fruit liquid medicine and sealing in soft capsule material, and the soft capsule material is prepared with gelatin, glycerin or other proper medicinal supplementary material and through mixing.
The hard capsule is prepared by adding a certain amount of medicinal material extract into medicinal powder or auxiliary materials to prepare uniform powder or granules and filling the powder or directly subpackaging the medicinal material powder into the hollow capsule.
The chewable soft capsule is mainly prepared from gelatin and glycerol, and has proper hardness and elasticity, and oily or emulsified mixture as main content, but is not easy to bite.
The technical defect of gelatin odor cannot be overcome in the prior art, the capsule prepared by only using gelatin cannot achieve an odorless effect, the gelatin capsule prepared by blending semi-synthetic high polymer materials such as hydroxypropyl methylcellulose and the like and gelatin has the problems of unstable quality and large quality difference in capsule batches, and the capsule prepared by using a fully synthetic high polymer material has no safety and cost advantages of gelatin, basically has no large-scale application value and has no practicability.
Disclosure of Invention
The invention aims to solve the technical problem of providing a preparation method of replacing gelatin by gelatin-starch mixed gum which is tasteless, odorless, extremely high in safety and low in cost.
In order to solve the technical scheme, the invention provides the following technical scheme:
the mixed glue composition comprises the following preparation raw materials in parts by weight: 8.0-9.4KG of glycerol, 17.5-19.8KG of purified water, 10.0-12.0KG of animal gelatin, 9.0-11.5KG of starch and 0.5-1.3KG of sweetener.
The following is a further optimization of the above technical solution of the present invention:
the mixed glue composition comprises the following components in parts by weight: 8.0KG of glycerol, 17.5KG of purified water, 10.0KG of animal gelatin, 9.0KG of starch and 0.5KG of sweetener;
further optimization: the mixed glue composition comprises the following components in parts by weight: 8.7KG of glycerol, 18.6KG of purified water, 11.0KG of animal gelatin, 10.2KG of starch and 0.9KG of sweetener;
further optimization: the mixed glue composition comprises the following components in parts by weight: 9.4KG of glycerol, 19.8KG of purified water, 12.0KG of animal gelatin, 11.5KG of starch and 1.3KG of sweetener;
further optimization: the glycerol is used as a plasticizer in capsule preparation, the appearance of the glycerol is colorless, transparent and odorless viscous liquid, the melting point of the glycerol is 20 ℃, the boiling point of the glycerol is 290 ℃, and the viscosity of the glycerol is 1412 mpa.s;
further optimization: the purified water is colorless and odorless clear liquid, is medicinal water prepared by distilling drinking water, ion exchange method, reverse osmosis method or other suitable method, and does not contain any additive;
further optimization: the animal gelatin is tasteless and odorless white or light yellow, semitransparent and slightly glossy sheet or powder, can absorb water in cold water to expand, is dissolved in hot water, and is dissolved in glycerol and acetic acid;
further optimization: the sweetener is sorbitol;
further optimization: the sorbitol is a white odorless liquid with a melting point of 95 ℃ and a boiling point of 296 ℃.
The invention also provides a preparation method of the mixed glue composition, which comprises the following steps:
s1, placing purified water of 17.5-19.8KG and glycerol of 8.0-9.4KG into a gelatin melting bucket and stirring to obtain a mixed product 1;
s2, adding 10.0-12.0KG of animal gelatin and 9.0-11.5KG of starch into the mixed product 1 and heating to obtain a mixed product 2;
s3, adding 0.5-1.3KG of sorbitol into the mixed product 2, starting to cook, and starting to vacuumize after all materials are completely gelatinized and transparent to obtain a mixed product 3;
s4, stopping stirring the mixed product 3 and continuously vacuumizing to obtain mixed glue;
and S5, standing the mixed gel for later use and placing the mixed gel in a heat preservation device.
The following is a further optimization of the above technical solution of the present invention:
and the stirring time of the purified water and the glycerol in the S1 is 30-60 min.
Further optimization: adding animal gelatin and starch into the mixed product 1 in the S2, wherein the heating temperature is 80-90 ℃;
further optimization: the cooking time for adding the sorbitol into the mixed product 2 in the S3 is 120-150 min;
further optimization: adding sorbitol into the mixed product 2 in the S3, and vacuumizing after all materials are completely gelatinized, wherein the vacuum degree is-0.060 Mpa, and the vacuumizing time is 3-5 min;
further optimization: after the mixed product 3 in the S4 stops stirring, continuously vacuumizing for 1 min;
further optimization: and placing the mixed glue in the S5 into a heat preservation device at the temperature of 58.0-65.0 ℃ for heat preservation, wherein the set temperature of the heat preservation device is 60 ℃.
The invention adopts the technical scheme and has the following beneficial effects:
1. the mixed glue composition produced by adopting the technical scheme solves the problems of peculiar smell and stink of only gelatin, the sweetening agent is added into the ingredients, so that the gelatin has no peculiar smell, the finished capsule can be easily swallowed by people, the use of the raw material formula has extremely high safety and low raw material cost, and the mixed glue composition has large-scale production value and extremely high practicability.
2. The glue melting barrel device is adopted to produce the mixed glue, the phenomenon that a large tank is burnt and wasted when a small amount of glue solution is dissolved is avoided, the mixed glue has the advantages of saving energy and material consumption, the electric heating type temperature control heating is adopted, the constant temperature performance is strong, the functions of accelerating the glue solution melting time, improving the liquid medium of the gelatin, stabilizing the homogeneity degree of the glue solution and the like are realized, the glue solution after being melted is directly conveyed and used by one process, and the bad phenomenon that bubbles are generated when the original glue solution is melted in vacuum and conveyed in a barrel is thoroughly solved.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail below with reference to specific embodiments, it should be understood that the specific embodiments described herein are only for the purpose of explaining the present invention and are not intended to limit the present invention.
Example 1: the mixed glue composition comprises the following preparation raw materials in parts by weight: 8.0KG of glycerol, 17.5KG of purified water, 10.0KG of animal gelatin, 9.0KG of starch and 0.5KG of sweetener.
The sweetener is sorbitol.
The preparation method of the mixed glue composition specifically comprises the following steps:
placing 17.5KG purified water and 8.0KG glycerol into a glue dissolving barrel of 150L, starting a stirring device, and stirring for 30min to obtain a mixed product 1;
adding 10.0KG of animal gelatin and 9KG of starch into the mixed product 1, and heating at 80 ℃ after the feeding is finished to obtain a mixed product 2;
adding 0.5KG sorbitol into the mixed product 2, starting cooking at negative pressure of-0.060 MPa after the liquid level is stable, wherein the cooking time is 120min, stirring and vacuumizing for 3 min when the vacuum degree is-0.060 MPa after all materials are completely gelatinized, and obtaining a mixed product 3;
stopping stirring the mixed product 3, and continuously vacuumizing for 1min to obtain mixed glue;
and standing the mixed glue, and then placing the mixed glue in a heat preservation device at 58.0 ℃ for heat preservation and storage, wherein the set temperature of the heat preservation device is 60 ℃.
Example 2: the mixed glue composition comprises the following preparation raw materials in parts by weight: 8.7KG of glycerol, 18.6KG of purified water, 11.0KG of animal gelatin, 10.2KG of starch and 0.9KG of sweetener.
The sweetener is sorbitol.
The preparation method of the mixed glue composition specifically comprises the following steps:
putting 18.6KG purified water and 8.7KG glycerol into a glue dissolving barrel of 150L, starting a stirring device, and stirring for 45min to obtain a mixed product 1;
adding 11.0KG of animal gelatin and 10.2KG of starch into the mixed product 1, and heating at 85 ℃ after the feeding is finished to obtain a mixed product 2;
adding 0.9KG sorbitol into the mixed product 2, starting cooking under negative pressure after the liquid level is stable, wherein the cooking time is 135min, stirring and vacuumizing for 4 min when the vacuum degree is-0.060 MPa after all materials are completely gelatinized, and obtaining a mixed product 3;
stopping stirring the mixed product 3, and continuously vacuumizing for 1min to obtain mixed glue;
and standing the mixed glue, and then placing the mixed glue in a heat preservation device at 61.5 ℃ for heat preservation and storage, wherein the set temperature of the heat preservation device is 60 ℃.
Example 3: the mixed glue composition comprises the following preparation raw materials in parts by weight: 9.4KG of glycerol, 19.8KG of purified water, 12.0KG of animal gelatin, 11.5KG of starch and 1.3KG of sweetening agent.
The sweetener is sorbitol.
The preparation method of the mixed glue composition specifically comprises the following steps:
placing 19.8KG purified water and 9.4KG glycerol into a glue dissolving barrel of 150L, starting a stirring device, and stirring for 60min to obtain a mixed product 1;
adding 12.0KG animal gelatin and 11.5KG starch into the mixed product 1, and heating at 90 ℃ after the feeding is finished to obtain a mixed product 2;
adding 1.3KG of sorbitol into the mixed product 2, starting cooking under negative pressure after the liquid level is stable, wherein the cooking time is 150min, stirring and vacuumizing for 5min when the vacuum degree is-0.060 MPa after all materials are completely gelatinized, and obtaining a mixed product 3;
stopping stirring the mixed product 3, and continuously vacuumizing for 1min to obtain mixed glue;
and standing the mixed glue, and then placing the mixed glue in a heat preservation device at 65.0 ℃ for heat preservation and storage, wherein the set temperature of the heat preservation device is 60 ℃.
Conclusion analysis
The results of the mixed gel testing are shown in the following table:
TABLE 1 physical index
| Index (I) | Prior Art | Example 1 | Example 2 | Example 3 |
| Water content% | 14.0 | 12.5 | 11.0 | 13.1 |
| Transparency, mm | 100 | 180 | 250 | 210 |
| Ash content% | 2.0 | 1.0 | 0.8 | 1.2 |
| Water-insoluble matter% | 0.3 | 0.18 | 0.15 | 0.2 |
| Peculiar smell | Has odor smell | Has no peculiar smell | Has no peculiar smell | Has no peculiar smell |
TABLE 2 Capsule testing
| Index (I) | Prior Art | Example 1 | Example 2 | Example 3 |
| Heavy metals, mg/kg | 50 | 21 | 13 | 24 |
| Chromium content, mg/kg | 0.5 | Is free of | Is free of | 0.2 |
| Number of bacteria, g | 1000 | 720 | 402 | 613 |
| Friability, grain/100 | 8 | 3 | 2 | 5 |
| Disintegration time limit, min | 12 | 8 | 6 | 10 |
Conclusion analysis: the mixed glue disclosed by the invention is superior to the gelatin in the prior art in each index by combining the tables 1 and 2, and solves the problem that the gelatin in the prior art has peculiar smell.
It will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in the embodiments described above without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims.
Claims (10)
1. A mixed glue composition is characterized in that: the raw materials specifically comprise the following components in parts by weight: 8.0-9.4KG of glycerol, 17.5-19.8KG of purified water, 10.0-12.0KG of animal gelatin, 9.0-11.5KG of starch and 0.5-1.3KG of sweetener.
2. The mixing glue composition according to claim 1, wherein: the sweetener is sorbitol.
3. The mixing glue composition according to claim 2, wherein: the glycerol as a plasticizer had a melting point of 20 ℃, a boiling point of 290 ℃ and a viscosity of 1412 mpa.s.
4. A glue blend composition according to claim 3, characterised in that: the sorbitol had a melting point of 95 ℃ and a boiling point of 296 ℃.
5. The method of preparing a hybrid glue composition according to claims 1-4, characterized in that:
s1, placing purified water of 17.5-19.8KG and glycerol of 8.0-9.4KG into a gelatin melting bucket and stirring to obtain a mixed product 1;
s2, adding 10.0-12.0KG of animal gelatin and 9.0-11.5KG of starch into the mixed product 1, and heating and stirring to obtain a mixed product 2;
s3, adding 0.5-1.3KG of sorbitol into the mixed product 2, starting to cook, and starting to vacuumize after all materials are completely gelatinized and transparent to obtain a mixed product 3;
s4, stopping stirring the mixed product 3 and continuously vacuumizing to obtain mixed glue;
and S5, standing the mixed gel for later use and placing the mixed gel in a heat preservation device.
6. The method for preparing a hybrid glue composition according to claim 5, characterized in that: and the stirring time of the purified water and the glycerol in the S1 is 60-60 min.
7. The method for preparing a hybrid glue composition according to claim 6, characterized in that: the heating temperature in the S2 is 80-90 ℃.
8. The method for preparing a hybrid glue composition according to claim 7, wherein: the cooking time in S3 is 120-150 min.
9. The method for preparing a hybrid glue composition according to claim 8, characterized in that: and (3) vacuumizing in the S3, wherein the vacuum degree is-0.060 MPa, and the vacuumizing time is 3-5 min.
10. The method for preparing a hybrid glue composition according to claim 9, characterized in that: the set temperature of the heat preservation equipment in the S5 is 60 ℃, and the heat preservation temperature is 58.0-65.0 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010386297.5A CN111420065A (en) | 2020-05-09 | 2020-05-09 | Mixed glue composition and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010386297.5A CN111420065A (en) | 2020-05-09 | 2020-05-09 | Mixed glue composition and preparation method thereof |
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| Publication Number | Publication Date |
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| CN111420065A true CN111420065A (en) | 2020-07-17 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010386297.5A Pending CN111420065A (en) | 2020-05-09 | 2020-05-09 | Mixed glue composition and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070077293A1 (en) * | 2003-11-26 | 2007-04-05 | Young-Soo CHA | Film-forming composition suitable for hard capsules and method for preparing the same |
| US7662406B1 (en) * | 2009-08-06 | 2010-02-16 | Viva Pharmaceutical Inc. | Chewable softgel capsules |
| CN104800190A (en) * | 2015-05-13 | 2015-07-29 | 吉林汇群生物工程有限公司 | Starch-based plant hard capsule for medicine and preparing method thereof |
-
2020
- 2020-05-09 CN CN202010386297.5A patent/CN111420065A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070077293A1 (en) * | 2003-11-26 | 2007-04-05 | Young-Soo CHA | Film-forming composition suitable for hard capsules and method for preparing the same |
| US7662406B1 (en) * | 2009-08-06 | 2010-02-16 | Viva Pharmaceutical Inc. | Chewable softgel capsules |
| CN104800190A (en) * | 2015-05-13 | 2015-07-29 | 吉林汇群生物工程有限公司 | Starch-based plant hard capsule for medicine and preparing method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 孙良初: "明胶在胶囊中的应用", 《明胶科学与技术》 * |
| 潘卫三等: "《工业药剂学》", 31 December 2019, 中国医药科技出版社 * |
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Application publication date: 20200717 |