CN111419326A - Cardiac tissue closure device - Google Patents
Cardiac tissue closure device Download PDFInfo
- Publication number
- CN111419326A CN111419326A CN201910023439.9A CN201910023439A CN111419326A CN 111419326 A CN111419326 A CN 111419326A CN 201910023439 A CN201910023439 A CN 201910023439A CN 111419326 A CN111419326 A CN 111419326A
- Authority
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- China
- Prior art keywords
- clamping
- arm
- auricle
- clamping arm
- cardiac tissue
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/122—Clamps or clips, e.g. for the umbilical cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12122—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder within the heart
Abstract
The invention provides a cardiac tissue closing device, and relates to the field of medical instruments. The device comprises a first clamping arm, a second clamping arm and an elastic piece; one end of the first clamping arm is rotatably connected with one end of the second clamping arm, and the elastic piece provides clamping force for the first clamping arm and the second clamping arm. According to the heart tissue closing device, the elastic piece provides clamping force, and the clamping force is applied to the outer sides of the first clamping arm and the second clamping arm, so that the clamping arms are driven to clamp the inner auricle flat, the auricle is closed, and the auricle can be prevented from being folded in the ligation process; the device can continuously give stable clamping force through the elastic part, and the auricle can still be completely closed when the atrophy thickness is reduced. The device improves area of contact through the multilayer parcel, prevents to tear the risk to heart tissue at the centre gripping in-process.
Description
Technical Field
The invention relates to the field of medical instruments, in particular to a cardiac tissue closing device.
Background
Atrial fibrillation is one of the most common clinical arrhythmia, the stroke result caused by atrial fibrillation is very serious, and the death rate and disability rate reach 70%. For patients with valvular atrial fibrillation, 57% of atrial thrombi originate in the left atrial appendage, and for patients with non-valvular atrial fibrillation, 90% of left atrial thrombi originate in the left atrial appendage. Even after sinus rhythm is restored, contraction of the left atrial appendage is arrested and thrombus may form. The auricle is located above the atrium, at the left side of the pulmonary artery and ascending aorta, between the left superior pulmonary vein and the mitral annulus, and is in a narrow and curved tubular cecum cavity structure.
At present, there are two main methods for clinically preventing cardiogenic ischemic stroke: pharmacotherapy and surgical intervention in the atrial appendage.
The medicine treatment is, for example, warfarin, but warfarin has higher bleeding risk and is difficult to apply clinically; warfarin also has the potential to cause osteoporosis and soft tissue necrosis.
The other method is to intervene the auricle in cardiac surgery, the surgical operation treatment of the auricle is divided into surgical operation treatment of the auricle and surgical instrument treatment of the auricle, wherein the common mode of the surgical intervention treatment is direct excision, suture and ligation of the auricle, the main defects of the method are that the surgical success rate is low, the surgical risk is high, the excision or suture points have high bleeding risk, and ligation has the recanalization risk of tearing and ligature loosening, the previous research shows that the success rate of the surgical operation treatment of the auricle is about 80 percent at the highest, and more adverse events exist after surgery.
Because the lasso of system is the annular, and in the operation process, the lasso is emboliaed from the auricle top, moves to the auricle root along auricle outer wall, because auricle tissue is the software tissue, and the auricle is by unordered folding in the operation process of ligation, and the piling up of folding department fold is in the same place, appears a lot of gaps, forms the risk of residual blood flow easily, and the stylolite can appear the pine and take off after the atrophy of auricle tissue simultaneously, and blood rethread risk, ligature have the risk of lacerating the tissue in addition, cause the tissue to tear easily.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides a cardiac tissue closing device, which solves the technical problem that disordered folding can occur in the treatment process of the existing surgical instrument to form residual blood flow.
(II) technical scheme
In order to achieve the purpose, the invention is realized by the following technical scheme:
a cardiac tissue closure device comprising:
a first clamp arm;
one end of the first clamping arm is rotatably connected with one end of the second clamping arm;
the elastic piece is used for providing clamping force for the first clamping arm and the second clamping arm.
Preferably, the elastic member includes:
the first clamping part is connected with the outer wall of the first clamping arm;
the second clamping part is connected with the outer wall of the second clamping arm;
an elastic bending part connecting the first clamping part and the second clamping part;
the elastic bending part provides clamping force for the first clamping arm and the second clamping arm through the first clamping part and the second clamping part.
Preferably, the first clamping portion and the outer wall of the first clamping arm are provided with a plurality of connection points, and the connection points are distributed along the length direction of the first clamping arm.
Preferably, the first clamping portion includes:
a first long clamp arm;
a first short clamping part arm, a first end of the first long clamping part arm and a first end of the first short clamping part arm being connected to a first end of the elastic bending part.
Preferably, the joint of the second end of the first long clamping part arm and the outer wall of the first clamping arm is a first clamping point;
the joint of the second end of the first short clamping part arm and the outer wall of the first clamping arm is a second clamping point;
and the first clamping point and the second clamping point are distributed along the length direction of the outer wall of the first clamping arm.
Preferably, the first clamping arm and the second clamping arm are in a wave-shaped structure with at least one protrusion.
Preferably, the first clamping arm and the second clamping arm are sleeved with protective sleeves.
(III) advantageous effects
The present invention provides a cardiac tissue closure device. Compared with the prior art, the method has the following beneficial effects:
according to the heart tissue closing device, the elastic piece provides clamping force, and the clamping force is applied to the outer sides of the first clamping arm and the second clamping arm, so that the clamping arms are driven to clamp the inner auricle flatly, the auricle is closed, a folding gap caused by ligation of the auricle can be prevented, and the risk of residual blood flow is avoided. By increasing the contact area of the device and the auricle tissues, the tearing of the auricle tissues caused by the undersize contact surface of the ligature is avoided. The device can continuously give stable clamping force through the elastic piece, and the auricle can be ensured to be completely closed when the atrophy thickness is reduced; the head end V font open structure of device breaks through the limitation of ligation mode, need not to embolia from the auricle top, opens the arm lock and inserts along the auricle root and seal, and the more convenient complicated operation of avoiding the ligation has improved the operation precision simultaneously from each angle implementation sealing operation at the auricle root.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a schematic overall view of a first structure according to an embodiment of the present invention;
FIG. 2 is a first perspective exploded view of a first configuration in accordance with an embodiment of the present invention;
FIG. 3 is a second perspective exploded view of the first configuration in accordance with the present invention;
FIG. 4 is a schematic view of a spring according to an embodiment of the present invention;
FIG. 5 is a top view of a first structure in accordance with an embodiment of the present invention;
FIG. 6 is a cross-sectional view A-A of FIG. 5;
FIG. 7 is a first perspective view of a second structure in accordance with the present invention;
FIG. 8 is a second perspective view of a second structure in accordance with the present invention;
FIG. 9 is a third perspective view of a second structure in accordance with the present invention;
FIG. 10 is a fourth perspective view of a second structure in accordance with the present invention;
FIG. 11 is a schematic diagram illustrating an overall fifth perspective view of a second structure in accordance with the present invention;
fig. 12 is a schematic view of a first structure and an atrial appendage holding apparatus according to an embodiment of the invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention are clearly and completely described, and it is obvious that the described embodiments are a part of the embodiments of the present invention, but not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The embodiment of the application provides a cardiac tissue closing device, and solves the technical problems that disordered folding can occur in the treatment process of the existing surgical instrument and residual blood flow is formed.
In order to solve the above problems, the technical solution in the embodiment of the present application has the following general idea:
the auricle is long and narrow cavity, and the heart tissue closing device of this embodiment is through first arm lock and the flat auricle of second arm lock clamp, can prevent the folding gap that the ligature auricle arouses, avoids remaining blood flow risk. By increasing the contact area of the device and the auricle tissues, the tearing of the auricle tissues caused by the undersize contact surface of the ligature is avoided. The device can continuously give stable clamping force through the elastic part, and the auricle can still be completely closed when the atrophy thickness is reduced.
In addition, the mode of annular closed lasso ligature is mostly adopted in current surgical instruments processing, need embolia the atrial appendage root with the ligature from the atrial appendage top, and the operation is more complicated, and the device adopts the opening design, need not embolia from the atrial appendage top, directly can act on the atrial appendage root, and is simple convenient.
In order to better understand the technical solution, the technical solution will be described in detail with reference to the drawings and the specific embodiments.
An embodiment of the present invention provides a cardiac tissue closure device, as shown in fig. 1 to 11, including: the clamping device comprises a first clamping arm 1, a second clamping arm 2 and an elastic piece 3;
one end of the first clamping arm 1 is rotatably connected with one end of the second clamping arm 2, specifically, a hinge connection, a pivot connection and the like can be adopted, and as shown in fig. 2 and 3, a connecting piece 4 is adopted to realize the rotary connection in a pivot connection mode; its main objective is that first arm lock 1 and second arm lock 2 can rotate around its junction, realizes opening and closing of first arm lock 1 and second arm lock 2, opens the state promptly and is the V word structure.
As shown in fig. 12, the first clip arm 1 and the second clip arm 2 are clamped to block the blood flow between the auricle 6 and the atrium 5, and the elastic member 3 provides a clamping force to the first clip arm 1 and the second clip arm 2, so that the auricle is closed.
Specifically, the material of the first arm lock 1 and the second arm lock 2 may be an implantable metal, such as stainless steel, cobalt-based alloy, platinum-iridium alloy, nickel-titanium alloy, magnesium-based alloy, iron-based alloy, or a polymer material, such as polytetrafluoroethylene, nylon, polyester, polyamide, polylactic acid, PGA, PDO, or the like.
Above-mentioned embodiment, come centre gripping auricle 4 through first arm lock 1 and second arm lock 2 under the effect of elastic component 3's clamping force, realize sealing the auricle, press from both sides flat auricle through the arm lock structure, can prevent the remaining blood flow risk in gap that ligature in-process auricle was folded and is leaded to, through open type structure, break through the limitation of ligation mode, need not to embolia to the auricle root from the auricle top, open the structure through the V font, can be more convenient from each angle directly implement the closed operation with the auricle bottom. And the elastic element 3 can continuously give stable clamping force to ensure that the auricle can be completely closed when the atrophy thickness is reduced.
In the above embodiment, as shown in fig. 2, 3 and 4, the elastic member 3 includes a first clamping portion 302, a second clamping portion 303 and an elastic bending portion 301, wherein the first clamping portion 302 is connected to an outer wall of the first clamping arm 1; the second clamping part 303 is connected with the outer wall of the second clamping arm 2; the elastic bending portion 301 connects the first clamping portion 302 and the second clamping portion 303, wherein the elastic bending portion 301 provides a clamping force for the first clamping portion 302 and the second clamping portion 303, so that the two generate a clamping force tending to close, and the elastic bending portion 301 provides a clamping force for the first clamping arm 1 and the second clamping arm 2 through the first clamping portion 302 and the second clamping portion 303.
Specifically, the elastic member 3 is made of an implantable metal, such as stainless steel, nitinol, or the like, or a polymer material, such as P LL A, P L GA, wherein the elastic bending portion 301 can be bent or curved by the above-mentioned material, and the bending is an arc-shaped structure to drive the arc-shaped deformation through the first holding portion 302 or the second holding portion 303, so as to provide the holding force.
The first clamping portion 302 and the second clamping portion 303 may be selected to be sheet-shaped structures, so as to increase the force-bearing area and improve the clamping effect.
In a specific implementation process, a plurality of connection points are arranged on the outer wall of the first clamping portion 302 and the outer wall of the first clamping arm 1, and the connection points are distributed along the length direction of the first clamping arm 1. In the implementation, the connection point between the first clamping portion 302 and the outer wall of the first clamping arm 1 is a clamping point, and a plurality of clamping points are provided through a plurality of connection points, and the connection points are distributed along the length direction of the first clamping arm 1, that is, a plurality of clamping points are distributed along the length direction of the first clamping arm 1, so as to ensure the uniform distribution of the clamping force.
Meanwhile, a plurality of connection points can be arranged between the second clamping portion 303 and the outer wall of the second clamping arm 2.
In one embodiment, the first clip portion 302 includes a first long clip portion arm 3022 and a first short clip portion arm 3021, the first end of the first long clamping part arm 3022 and the first end of the first short clamping part arm 3021 are connected to the first end of the elastic bending part 301, and the specific first clamping part 302 is composed of the first long clamping part arm 3022 and the first short clamping part arm 3021, and are distributed along the width direction of the first clamp arm 1, and the ends of the first long clamp arm 3022 and the first short clamp arm 3021 are integrated, and converge at the first end of the elastic bend 301, it can also be understood that the first clip portion 302 is divided into two parts along the width direction, namely a first long clip portion arm 3022 and a first short clip portion arm 3021, i.e. the two parts have different lengths, the skilled person can also choose to divide the two parts into more than two parts according to the needs.
In a specific implementation process, a joint between the second end of the first long clamping part arm 3022 and the outer wall of the first clamping arm 1 is a first clamping point 304;
the joint between the second end of the first short clamping part arm 3021 and the outer wall of the first clamping arm 1 is a second clamping point 305;
the first clamping point 304 and the second clamping point 305 are distributed along the length direction of the outer wall of the first clamping arm 1. That is, in the above embodiment, the first clamping portion 302 is divided into the clamping points with different lengths along the width direction of the clamping arm, namely, the first long clamping portion arm 3022 and the first short clamping portion arm 3021, and the second end portion of the first long clamping portion arm 3022 and the second end portion of the first short clamping portion arm 3021 are connected to the outer wall of the first clamping arm 1, namely, the clamping points, and the first clamping portion 302 is divided into the clamping arms with different lengths along the width direction thereof, so that the plurality of clamping points are distributed along the length direction of the first clamping arm 1.
Meanwhile, the second clamping portion 303 may also realize the distribution of the plurality of clamping points through the above scheme.
In a specific implementation process, an embodiment of the present invention provides two types of clamp arm structures, where a first type of clamp arm structure is shown in fig. 1 to 6, where the first clamp arm 1 and the second clamp arm 2 are in a straight-plate type structure, a straight-tube type structure, and the like, that is, in a linear structure.
When adopting first kind of arm lock structure, for the convenience arm lock and elastic component 3 be connected, set up recess 101 along its length direction in the outside of arm lock, the clamping part and the cooperation of recess 101 of elastic component 3 to carry out fixed connection through welding, bolt or rivet etc. specifically as shown in figure 2, recess 101 cooperates with first long clamping part arm 3022, and first long clamping part arm 3022 imbeds to recess 101 in, and is fixed again.
The second clamping arm structure is shown in fig. 7-11, wherein the first clamping arm 1 and the second clamping arm 2 are of a raised wave-shaped structure, clamped tissues can be blocked in a regional mode through the clamping arms of the wave-shaped structure, and the clamping effect is improved through regional blocking.
When the second type of clamping arm structure is adopted, the first clamping portion 302 or the second clamping portion 303 may be connected to the protruding position of the clamping arm, that is, the protruding position of the clamping arm is a clamping point.
In the specific implementation process, the first clamping arm 1 and the second clamping arm 2 are sleeved with a protective sleeve, and the protective sleeve is used for increasing the stress area and preventing the auricle from being torn.
Specifically, the protective sleeve can be made of a single material or a multi-layer composite polymer material, and can be made of polymer materials such as polyester, silica gel, polyurethane and the like, and can also be made of metal wire woven meshes such as nickel-titanium alloy and stainless steel.
Embodiments of the present invention provide a cardiac tissue closure device. Compared with the prior art, the method has the following beneficial effects:
according to the heart tissue closing device, the elastic piece provides clamping force, and the clamping force is applied to the outer sides of the first clamping arm and the second clamping arm, so that the clamping arms are driven to clamp the inner auricle flatly, the auricle is closed, a folding gap caused by ligation of the auricle can be prevented, and the risk of residual blood flow is avoided. By increasing the contact area of the device and the auricle tissues, the tearing of the auricle tissues caused by the undersize contact surface of the ligature is avoided. The device can continuously give stable clamping force through the elastic piece, and the auricle can be ensured to be completely closed when the atrophy thickness is reduced; the head end V font open structure of device breaks through the limitation of ligation mode, need not to embolia from the auricle top, opens the arm lock and inserts along the auricle root and seal, and the more convenient complicated operation of avoiding the ligation has improved the operation precision simultaneously from each angle implementation sealing operation at the auricle root.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.
The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (7)
1. A cardiac tissue closure device, comprising:
a first clamp arm;
one end of the first clamping arm is rotatably connected with one end of the second clamping arm;
the elastic piece is used for providing clamping force for the first clamping arm and the second clamping arm.
2. The cardiac tissue closure device of claim 1, wherein the resilient member comprises:
the first clamping part is connected with the outer wall of the first clamping arm;
the second clamping part is connected with the outer wall of the second clamping arm;
an elastic bending part connecting the first clamping part and the second clamping part;
the elastic bending part provides clamping force for the first clamping arm and the second clamping arm through the first clamping part and the second clamping part.
3. The cardiac tissue closure device of claim 2, wherein the first clip portion and the outer wall of the first clip arm are provided with a plurality of attachment points, and wherein the attachment points are distributed along the length of the first clip arm.
4. The cardiac tissue closure device of claim 2, wherein the first clamp comprises:
a first long clamp arm;
a first short clamping part arm, a first end of the first long clamping part arm and a first end of the first short clamping part arm being connected to a first end of the elastic bending part.
5. The cardiac tissue closure device of claim 4, wherein the junction of the second end of the first long clamp arm and the outer wall of the first clamp arm is a first clamp point;
the joint of the second end of the first short clamping part arm and the outer wall of the first clamping arm is a second clamping point;
and the first clamping point and the second clamping point are distributed along the length direction of the outer wall of the first clamping arm.
6. The cardiac tissue closure device of claim 1, wherein the first clip arm and the second clip arm have an undulating configuration with at least one projection.
7. The cardiac tissue closure device of any one of claims 1-6, wherein the first and second clip arms are externally sheathed with a protective sheath.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910023439.9A CN111419326A (en) | 2019-01-10 | 2019-01-10 | Cardiac tissue closure device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910023439.9A CN111419326A (en) | 2019-01-10 | 2019-01-10 | Cardiac tissue closure device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111419326A true CN111419326A (en) | 2020-07-17 |
Family
ID=71546611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910023439.9A Pending CN111419326A (en) | 2019-01-10 | 2019-01-10 | Cardiac tissue closure device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111419326A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113616388A (en) * | 2021-10-12 | 2021-11-09 | 上海御瓣医疗科技有限公司 | Clip for sandwiching biological tissue of heart valve |
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|---|---|---|---|---|
| US3326217A (en) * | 1964-04-27 | 1967-06-20 | Kerr Harry Sydney | Hemostatic clamp |
| US4414721A (en) * | 1980-11-07 | 1983-11-15 | Hufnagel Charles A | Occlusive clip and applicator for constricting flexible tubular members |
| US4781197A (en) * | 1984-04-12 | 1988-11-01 | Fukuda Denshi Co., Ltd. | Clip type electrode for electrocardiographs |
| CN201510373U (en) * | 2009-09-08 | 2010-06-23 | 广州医学院第一附属医院 | Porous elastic vessel clip |
| CN201939420U (en) * | 2011-01-20 | 2011-08-24 | 张羽 | Hemostat |
| US20140142597A1 (en) * | 2012-11-21 | 2014-05-22 | Atricure, Inc. | Occlusion clip |
| CN204500843U (en) * | 2015-03-12 | 2015-07-29 | 洪俊平 | A kind of umbilical cord cuts off folder |
| US20160008001A1 (en) * | 2013-11-21 | 2016-01-14 | Atricure, Inc. | Occlusion clip |
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2019
- 2019-01-10 CN CN201910023439.9A patent/CN111419326A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3326217A (en) * | 1964-04-27 | 1967-06-20 | Kerr Harry Sydney | Hemostatic clamp |
| US4414721A (en) * | 1980-11-07 | 1983-11-15 | Hufnagel Charles A | Occlusive clip and applicator for constricting flexible tubular members |
| US4781197A (en) * | 1984-04-12 | 1988-11-01 | Fukuda Denshi Co., Ltd. | Clip type electrode for electrocardiographs |
| CN201510373U (en) * | 2009-09-08 | 2010-06-23 | 广州医学院第一附属医院 | Porous elastic vessel clip |
| CN201939420U (en) * | 2011-01-20 | 2011-08-24 | 张羽 | Hemostat |
| US20140142597A1 (en) * | 2012-11-21 | 2014-05-22 | Atricure, Inc. | Occlusion clip |
| US20160008001A1 (en) * | 2013-11-21 | 2016-01-14 | Atricure, Inc. | Occlusion clip |
| CN204500843U (en) * | 2015-03-12 | 2015-07-29 | 洪俊平 | A kind of umbilical cord cuts off folder |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113616388A (en) * | 2021-10-12 | 2021-11-09 | 上海御瓣医疗科技有限公司 | Clip for sandwiching biological tissue of heart valve |
| CN113616388B (en) * | 2021-10-12 | 2022-01-21 | 上海御瓣医疗科技有限公司 | Clip for sandwiching biological tissue of heart valve |
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Inventor after: Li Li Inventor after: Wang Xudong Inventor after: Cui Jianpei Inventor after: Zhang Wenchao Inventor before: Li Jinshan Inventor before: Zheng Shuai Inventor before: Li Li Inventor before: Wang Xudong Inventor before: Zheng Zhe |
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Effective date of registration: 20230616 Address after: No. 5, Zhuyuan 2nd Street, Shunyi District, Beijing (Tianzhu Comprehensive Bonded Zone) Applicant after: Beijing medipeak Medical Technology Co.,Ltd. Address before: 102200 room 111, 1st floor, building 3, No. 11, Chaoqian Road, Changping Park, Zhongguancun Science and Technology Park, Changping District, Beijing Applicant before: BEIJING KANGRUIDI MEDICAL TECHNOLOGY Co.,Ltd. |