CN111418829A - Pilose antler blood freeze-dried powder buccal tablet and preparation method thereof - Google Patents
Pilose antler blood freeze-dried powder buccal tablet and preparation method thereof Download PDFInfo
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- CN111418829A CN111418829A CN202010245866.4A CN202010245866A CN111418829A CN 111418829 A CN111418829 A CN 111418829A CN 202010245866 A CN202010245866 A CN 202010245866A CN 111418829 A CN111418829 A CN 111418829A
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- antler blood
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- blood
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Abstract
The invention relates to the technical field of health products, in particular to a pilose antler blood freeze-dried powder buccal tablet and a preparation method thereof. The antler blood freeze-dried powder buccal tablet comprises the following components in parts by weight: 60-80 parts of pilose antler blood freeze-dried powder, 8-16 parts of sea buckthorn, 8-16 parts of snow chrysanthemum, 8-16 parts of liquorice, 6-12 parts of momordica grosvenori, 6-12 parts of black sesame, 4-8 parts of red date, 4-8 parts of poria cocos, 4-8 parts of gardenia, 4-8 parts of flavoring agent and 1-3 parts of adhesive; the tonic wine has mild tonic property, and all the components are mutually coordinated, so that the use is safer and healthier. The preparation method comprises the following steps: preparing antler blood freeze-dried powder; processing auxiliary materials; mixing, granulating and tabletting; the method is simple, can fully extract the nutrient components in each component, and ensures that each nutrient component is easier to be absorbed by human bodies.
Description
Technical Field
The invention relates to the technical field of health products, and particularly relates to a pilose antler blood freeze-dried powder buccal tablet and a preparation method thereof.
Background
The pilose antler blood is fresh blood obtained by extracting fresh pilose antler by using a vacuum pump when the hairy antler is harvested, the pilose antler blood is similar to the pilose antler in components, the pilose antler blood has heat without dryness, the effects of tonifying kidney and strengthening yang, strengthening muscles and bones, generating essence and benefiting marrow, and dispelling wind-damp, and the pilose antler blood wine is prepared from the pilose antler blood wine.
Therefore, many health care products on the market adopt antler blood as a raw material, but in the traditional health care products, the functions of all components are similar and belong to tonifying Yang, so that the health care products have an excessively strong Yang tonifying effect, the problems of dysphoria, anxiety, insomnia and the like can occur after the health care products are taken, and the most serious risks of hemorrhage and the like can occur.
Disclosure of Invention
The invention aims to provide the pilose antler blood freeze-dried powder buccal tablet which is mild in tonic property, mutually coordinated in components and safer and healthier to use.
The invention also aims to provide a preparation method of the pilose antler blood freeze-dried powder buccal tablet, which is simple to prepare, can fully extract the nutrient components in each component and ensures that each nutrient component is easier to be absorbed by human bodies.
The technical problem to be solved by the invention is realized by adopting the following technical scheme.
The invention provides a pilose antler blood freeze-dried powder buccal tablet which comprises the following components in parts by weight: 60-80 parts of pilose antler blood freeze-dried powder, 8-16 parts of sea buckthorn, 8-16 parts of snow chrysanthemum, 8-16 parts of liquorice, 6-12 parts of momordica grosvenori, 6-12 parts of black sesame, 4-8 parts of red dates, 4-8 parts of poria cocos, 4-8 parts of gardenia, 4-8 parts of flavoring agents and 1-3 parts of adhesives.
Further, in some embodiments of the present invention, the composition comprises the following components in parts by weight: 70 parts of pilose antler blood freeze-dried powder, 12 parts of sea buckthorn, 12 parts of snow chrysanthemum, 12 parts of liquorice, 9 parts of momordica grosvenori, 9 parts of black sesame, 6 parts of red date, 6 parts of poria cocos, 6 parts of gardenia, 6 parts of flavoring agent and 2 parts of adhesive.
further, in some embodiments of the present invention, the flavoring agent is one or more of stevioside, sucralose, sucrose, xylitol, fructo-oligosaccharide, malto-oligosaccharide, glycyrrhizin, L-arabinose, citric acid, and sodium citrate.
Further, in some embodiments of the present invention, the adhesive is one or more of starch slurry, dextrin slurry, or microcrystalline cellulose.
The invention provides a preparation method of the pilose antler blood freeze-dried powder buccal tablet, which comprises the following steps: preparing antler blood freeze-dried powder: carrying out low-temperature ultrasonic pyrolysis on frozen antler blood, placing the pyrolyzed antler blood into a freeze drying device for freeze drying treatment, and then placing the freeze-dried antler blood into an ultramicro pulverizer for ultramicro pulverization to obtain antler blood freeze-dried powder; auxiliary material treatment: cleaning and drying fructus Hippophae, coreopsis tinctoria, Glycyrrhrizae radix, fructus Siraitiae Grosvenorii, semen Sesami Niger, fructus Jujubae, Poria and fructus Gardeniae, respectively, and micronizing in micronizer to obtain fructus Hippophae powder, herba Centellae powder, Glycyrrhrizae radix powder, fructus Siraitiae Grosvenorii powder, semen Sesami Niger powder, fructus Jujubae powder, Poria powder and fructus Gardeniae powder; mixing, granulating and tabletting: mixing the prepared antler blood freeze-dried powder, sea buckthorn powder, snow inulin, liquorice powder, momordica grosvenori powder, black sesame powder, red date powder, tuckahoe powder and gardenia powder according to the following weight parts: 60-80 parts of antler blood freeze-dried powder, 8-16 parts of sea buckthorn, 8-16 parts of snow chrysanthemum, 8-16 parts of liquorice, 6-12 parts of momordica grosvenori, 6-12 parts of black sesame, 4-8 parts of red date, 4-8 parts of poria cocos, 4-8 parts of gardenia, 4-8 parts of flavoring agent and 1-3 parts of adhesive are added, mixed, added into a granulator for granulation, and then tabletted by a tabletting machine to obtain the antler blood freeze-dried powder buccal tablet.
Further, in some embodiments of the present invention, the content of the lyophilized pilose antler powder in each tablet of the lyophilized pilose antler powder buccal tablet is 0.1-0.2 g.
Further, in some embodiments of the present invention, in the preparation process of the lyophilized powder of pilose antler blood, before the frozen pilose antler blood is subjected to low-temperature ultrasonic pyrolysis, the pilose antler blood is mixed with white spirit according to a weight ratio of 2:5 to obtain a pilose antler blood solution, then active water is added to the mixture to be stirred and emulsified, the weight ratio of the active water to the pilose antler blood solution is 1:3, viscous pilose antler blood is obtained after emulsification, the viscous pilose antler blood is sent to a crusher to be crushed, and the crushed viscous pilose antler blood is sent to a material tray of a freeze dryer to be subjected to freezing treatment.
Further, in some embodiments of the present invention, the above active water preparation process is: adding an activating agent into distilled water, and mixing by ultrasonic vibration, wherein the weight ratio of the activating agent to the distilled water is as follows: 5-10:300.
Further, in some embodiments of the present invention, the activator is a sucrose ester activator.
Further, in some embodiments of the present invention, in the processing of the auxiliary materials, the drying temperature is 35 to 65 ℃ and the drying time is 30 to 80 min.
The pilose antler blood freeze-dried powder buccal tablet and the preparation method thereof provided by the invention have at least the following beneficial effects:
In the pilose antler blood freeze-dried powder buccal tablet: antler blood freeze-dried powder: the freeze-dried powder prepared from fresh blood obtained by extracting fresh pilose antler by using a vacuum pump when cutting red deer or spotted deer antler has the components similar to the components of the pilose antler, has the advantages of heat resistance, kidney tonifying, yang strengthening, muscles and bones strengthening, essence generation, marrow benefiting, rheumatism dispelling and wine namely the pilose antler blood wine, has better effect, can refresh the spirit and strengthen the body after being taken, and has better effect than the common pilose antler blood, and the pilose antler blood adopting the form of the freeze-dried powder is easier for a human body to absorb the nutritional components; sea-buckthorn: the vitamin C has high content, and the vitamin has the beauty of the king of the vitamin C, and has the effects of relieving cough and reducing sputum, invigorating stomach and promoting digestion, and activating blood circulation to dissipate blood stasis; modern medical research shows that the sea buckthorn can reduce cholesterol, relieve angina attack and prevent and treat coronary atherosclerotic heart disease; snow chrysanthemum: bitter and pungent in flavor, slightly cold in nature, entering lung and liver meridians. The coreopsis tinctoria comprises more than 30 flavonoids, more than 30 mineral elements necessary for human bodies, more than 20 amino acids, dozens of aromatic compounds, and abundant natural components with biological activity such as organic acid, terpenes, vitamins, lignans, enzymes, polysaccharides and the like; modern pharmacological research shows that volatile oil, total saponins, amino acids and flavonoids in the snow chrysanthemum can resist pathogens and enhance the resistance of capillary vessels, wherein the content of the total flavonoids reaches 12 percent, the flavonoids are strong antioxidants and can effectively remove oxygen free radicals in vivo, the oxidation prevention capacity is more than 10 times of that of vitamin E, the degeneration, the aging and the canceration of cells can be prevented, and the biological total flavonoids, terpenoids and sulfur-containing compounds which are rich in the snow chrysanthemum and are collectively called as factors with the immunoregulation function are important elements in medicaments related to blood pressure reduction, blood fat reduction, blood sugar regulation, tumor resistance and aging resistance; licorice root: sweet taste, mild nature and no toxicity; has effects in clearing away heat and toxic materials, eliminating phlegm, relieving cough, and relieving epigastric and abdominal pain; can be used for treating heart-qi deficiency, cardiopalmus, severe palpitation, intermittent pulse, deficiency of spleen-qi and stomach-qi, listlessness, debilitation, superficial infection, pyocutaneous disease, and sore throat; momordica grosvenori: sweet in taste and cool in nature; entering lung and large intestine meridians; can be used for treating heat clearing, lung moistening, cough relieving, sore throat relieving, intestine smoothing, and constipation relieving. Can be used for treating cough due to lung fire, pharyngalgia, aphonia, and constipation due to intestinal dryness; black sesame seed: the functions are mainly used for treating dizziness and tinnitus, atrophy and softness of waist and feet, early white beard and hair, dry skin, constipation due to intestinal dryness, less breast of women, carbuncle, sore, eczema and rheumatism, which are caused by deficiency of essence and blood of liver and kidney. In addition, the black sesame contains a large amount of fat and protein, and nutrient components such as sugar, vitamin A, vitamin E, lecithin, calcium, iron, chromium and the like, has sweet taste and oil fragrance, has the effects of nourishing liver and kidney, moistening the five internal organs, benefiting strength, growing muscle and filling brain marrow, and can supplement physical strength and strengthen physique when being taken together with the traditional Chinese medicines; red dates: sweet taste and warm nature; spleen and stomach meridians entered; has the effects of invigorating spleen, replenishing qi, nourishing blood, and tranquilizing; can be used for treating spleen deficiency, anorexia, asthenia, loose stool, and hysteria of women; tuckahoe, poria cocos: sweet taste, bland nature; heart, lung and spleen meridians entered; has effects of eliminating dampness, promoting diuresis, invigorating spleen, regulating stomach function, calming heart, tranquilizing mind, enhancing immunity, resisting tumor, and lowering blood sugar. Can be used for treating dysuria, edema, distention, phlegm retention, cough, vomiting, aversion to obstruction, diarrhea, spermatorrhea, stranguria with turbid urine, palpitation, and amnesia; gardenia: bitter taste, cold nature and no toxicity; has the effects of removing heat-toxin wind, removing seasonal fever, relieving five kinds of jaundice, benefiting five kinds of stranguria, promoting urination, quenching thirst and improving eyesight; can be used for treating hematemesis, epistaxis, bloody flux, stranguria with blood, blood stasis, typhoid fever, overstrain, heat syncope, headache, hernia, and scald; flavoring agent: can cover some bad tastes in the buccal tablets, so that the comfort level of taking the buccal tablets is better, the taking interest of a user is improved, and the effect of the buccal tablets is effectively exerted. Adhesive: the adhesive makes the shape of the buccal tablet more stable, avoids the buccal tablet from dispersing in the storage process, ensures the appearance stability of the buccal tablet and improves the taking comfort of a user.
The components are as follows by weight: 60-80 parts of pilose antler blood freeze-dried powder, 8-16 parts of sea buckthorn, 8-16 parts of snow chrysanthemum, 8-16 parts of liquorice, 6-12 parts of momordica grosvenori, 6-12 parts of black sesame, 4-8 parts of red date, 4-8 parts of poria cocos, 4-8 parts of gardenia, 4-8 parts of flavoring agent and 1-3 parts of adhesive are combined, so that the pilose antler blood freeze-dried powder is good in taste, and the sea buckthorn, the snow chrysanthemum, the momordica grosvenori and the gardenia are combined with the pilose antler blood freeze-dried powder, so that dryness of the pilose antler blood freeze-dried powder buccal tablet is reduced, the buccal tablet is mild in tonifying property, and is.
The antler blood freeze-dried powder buccal tablet prepared by the method can simply prepare antler blood freeze-dried powder in the antler blood freeze-dried powder preparation process, and enables nutrient substances in the antler blood to be absorbed more easily; in the auxiliary material treatment process, the auxiliary materials are crushed by an ultrafine crusher to be ultrafine powder, so that the taking feeling is better; then mixing, granulating and tabletting to obtain the antler blood freeze-dried powder buccal tablet which is convenient to carry and eat.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.
The invention provides a pilose antler blood freeze-dried powder buccal tablet which comprises the following components in parts by weight: 60-80 parts of pilose antler blood freeze-dried powder, 8-16 parts of sea buckthorn, 8-16 parts of snow chrysanthemum, 8-16 parts of liquorice, 6-12 parts of momordica grosvenori, 6-12 parts of black sesame, 4-8 parts of red dates, 4-8 parts of poria cocos, 4-8 parts of gardenia, 4-8 parts of flavoring agents and 1-3 parts of adhesives.
In the above embodiment:
Antler blood freeze-dried powder: the freeze-dried powder prepared from fresh blood obtained by extracting fresh pilose antler by using a vacuum pump when cutting red deer or spotted deer antler has the components similar to the components of the pilose antler, has the advantages of heat resistance, kidney tonifying, yang strengthening, muscles and bones strengthening, essence generation, marrow benefiting, rheumatism dispelling and wine namely the pilose antler blood wine, has better effect, can refresh the spirit and strengthen the body after being taken, and has better effect than the common pilose antler blood, and the pilose antler blood adopting the form of the freeze-dried powder is easier for a human body to absorb the nutritional components;
Sea-buckthorn: the vitamin C has high content, and the vitamin has the beauty of the king of the vitamin C, and has the effects of relieving cough and reducing sputum, invigorating stomach and promoting digestion, and activating blood circulation to dissipate blood stasis; modern medical research shows that the sea buckthorn can reduce cholesterol, relieve angina attack and prevent and treat coronary atherosclerotic heart disease;
Snow chrysanthemum: bitter and pungent in flavor, slightly cold in nature, entering lung and liver meridians. The coreopsis tinctoria comprises more than 30 flavonoids, more than 30 mineral elements necessary for human bodies, more than 20 amino acids, dozens of aromatic compounds, and abundant natural components with biological activity such as organic acid, terpenes, vitamins, lignans, enzymes, polysaccharides and the like; modern pharmacological research shows that volatile oil, total saponins, amino acids and flavonoids in the snow chrysanthemum can resist pathogens and enhance the resistance of capillary vessels, wherein the content of the total flavonoids reaches 12 percent, the flavonoids are strong antioxidants and can effectively remove oxygen free radicals in vivo, the oxidation prevention capacity is more than 10 times of that of vitamin E, the degeneration, the aging and the canceration of cells can be prevented, and the biological total flavonoids, terpenoids and sulfur-containing compounds which are rich in the snow chrysanthemum and are collectively called as factors with the immunoregulation function are important elements in medicaments related to blood pressure reduction, blood fat reduction, blood sugar regulation, tumor resistance and aging resistance;
Licorice root: sweet taste, mild nature and no toxicity; has effects in clearing away heat and toxic materials, eliminating phlegm, relieving cough, and relieving epigastric and abdominal pain; can be used for treating heart-qi deficiency, cardiopalmus, severe palpitation, intermittent pulse, deficiency of spleen-qi and stomach-qi, listlessness, debilitation, superficial infection, pyocutaneous disease, and sore throat;
Momordica grosvenori: sweet in taste and cool in nature; entering lung and large intestine meridians; can be used for treating heat clearing, lung moistening, cough relieving, sore throat relieving, intestine smoothing, and constipation relieving. Can be used for treating cough due to lung fire, pharyngalgia, aphonia, and constipation due to intestinal dryness;
Black sesame seed: the functions are mainly used for treating dizziness and tinnitus, atrophy and softness of waist and feet, early white beard and hair, dry skin, constipation due to intestinal dryness, less breast of women, carbuncle, sore, eczema and rheumatism, which are caused by deficiency of essence and blood of liver and kidney. In addition, the black sesame contains a large amount of fat and protein, and nutrient components such as sugar, vitamin A, vitamin E, lecithin, calcium, iron, chromium and the like, has sweet taste and oil fragrance, has the effects of nourishing liver and kidney, moistening the five internal organs, benefiting strength, growing muscle and filling brain marrow, and can supplement physical strength and strengthen physique when being taken together with the traditional Chinese medicines;
Red dates: sweet taste and warm nature; spleen and stomach meridians entered; has the effects of invigorating spleen, replenishing qi, nourishing blood, and tranquilizing; can be used for treating spleen deficiency, anorexia, asthenia, loose stool, and hysteria of women;
Tuckahoe, poria cocos: sweet taste, bland nature; heart, lung and spleen meridians entered; has effects of eliminating dampness, promoting diuresis, invigorating spleen, regulating stomach function, calming heart, tranquilizing mind, enhancing immunity, resisting tumor, and lowering blood sugar. Can be used for treating dysuria, edema, distention, phlegm retention, cough, vomiting, aversion to obstruction, diarrhea, spermatorrhea, stranguria with turbid urine, palpitation, and amnesia;
Gardenia: bitter taste, cold nature and no toxicity; has the effects of removing heat-toxin wind, removing seasonal fever, relieving five kinds of jaundice, benefiting five kinds of stranguria, promoting urination, quenching thirst and improving eyesight; can be used for treating hematemesis, epistaxis, bloody flux, stranguria with blood, blood stasis, typhoid fever, overstrain, heat syncope, headache, hernia, and scald;
Flavoring agent: can cover some bad tastes in the buccal tablets, so that the comfort level of taking the buccal tablets is better, the taking interest of a user is improved, and the effect of the buccal tablets is effectively exerted.
Adhesive: the adhesive makes the shape of the buccal tablet more stable, avoids the buccal tablet from dispersing in the storage process, ensures the appearance stability of the buccal tablet and improves the taking comfort of a user.
The components are as follows by weight: 60-80 parts of pilose antler blood freeze-dried powder, 8-16 parts of sea buckthorn, 8-16 parts of snow chrysanthemum, 8-16 parts of liquorice, 6-12 parts of momordica grosvenori, 6-12 parts of black sesame, 4-8 parts of red date, 4-8 parts of poria cocos, 4-8 parts of gardenia, 4-8 parts of flavoring agent and 1-3 parts of adhesive are combined, so that the pilose antler blood freeze-dried powder is good in taste, and the sea buckthorn, the snow chrysanthemum, the momordica grosvenori and the gardenia are combined with the pilose antler blood freeze-dried powder, so that dryness of the pilose antler blood freeze-dried powder buccal tablet is reduced, the buccal tablet is mild in tonifying property, and is.
Further, in some embodiments of the present invention, the composition comprises the following components in parts by weight: 70 parts of pilose antler blood freeze-dried powder, 12 parts of sea buckthorn, 12 parts of snow chrysanthemum, 12 parts of liquorice, 9 parts of momordica grosvenori, 9 parts of black sesame, 6 parts of red date, 6 parts of poria cocos, 6 parts of gardenia, 6 parts of flavoring agent and 2 parts of adhesive. The pilose antler blood freeze-dried powder buccal tablets prepared by adopting the proportion have better synergistic effect among the components, and can bring the nutritional value of each component into play to the best.
furthermore, in some embodiments of the present invention, the flavoring agent is one or more of stevioside, sucralose, sucrose, xylitol, fructo-oligosaccharide, malto-oligosaccharide, glycyrrhizin, L-arabinose, citric acid, and sodium citrate, and the use of any one or more of the flavoring agents can improve the taste of the buccal tablet, and simultaneously avoid damage to nutrients in the buccal tablet, so that the buccal tablet can be taken healthily.
Further, in some embodiments of the present invention, the adhesive is one or more of starch slurry, dextrin slurry, or microcrystalline cellulose. Any one or more of the adhesives are selected for mixing use, so that the stability of the shape of the buccal tablet is ensured, and meanwhile, the nutrient substances in the buccal tablet are prevented from being damaged, and the buccal tablet is healthier to take.
The invention provides a preparation method of the pilose antler blood freeze-dried powder buccal tablet, which comprises the following steps: preparing antler blood freeze-dried powder: carrying out low-temperature ultrasonic pyrolysis on frozen antler blood, placing the pyrolyzed antler blood into a freeze drying device for freeze drying treatment, and then placing the freeze-dried antler blood into an ultramicro pulverizer for ultramicro pulverization to obtain antler blood freeze-dried powder; auxiliary material treatment: cleaning and drying fructus Hippophae, coreopsis tinctoria, Glycyrrhrizae radix, fructus Siraitiae Grosvenorii, semen Sesami Niger, fructus Jujubae, Poria and fructus Gardeniae, respectively, and micronizing in micronizer to obtain fructus Hippophae powder, herba Centellae powder, Glycyrrhrizae radix powder, fructus Siraitiae Grosvenorii powder, semen Sesami Niger powder, fructus Jujubae powder, Poria powder and fructus Gardeniae powder; mixing, granulating and tabletting: mixing the prepared antler blood freeze-dried powder, sea buckthorn powder, snow inulin, liquorice powder, momordica grosvenori powder, black sesame powder, red date powder, tuckahoe powder and gardenia powder according to the following weight parts: 60-80 parts of antler blood freeze-dried powder, 8-16 parts of sea buckthorn, 8-16 parts of snow chrysanthemum, 8-16 parts of liquorice, 6-12 parts of momordica grosvenori, 6-12 parts of black sesame, 4-8 parts of red date, 4-8 parts of poria cocos, 4-8 parts of gardenia, 4-8 parts of flavoring agent and 1-3 parts of adhesive are added, mixed, added into a granulator for granulation, and then tabletted by a tabletting machine to obtain the antler blood freeze-dried powder buccal tablet.
The antler blood freeze-dried powder buccal tablet prepared by the method can simply prepare antler blood freeze-dried powder in the antler blood freeze-dried powder preparation process, and enables nutrient substances in the antler blood to be absorbed more easily; in the auxiliary material treatment process, the auxiliary materials are crushed by an ultrafine crusher to be ultrafine powder, so that the taking feeling is better; then mixing, granulating and tabletting to obtain the antler blood freeze-dried powder buccal tablet which is convenient to carry and eat.
Further, in some embodiments of the present invention, the content of the lyophilized pilose antler powder in each tablet of the lyophilized pilose antler powder buccal tablet is 0.1-0.2 g. Therefore, the eater can select to take 1-6 tablets every day according to the self condition, the eating by the eater is more convenient, and the eating effectiveness of the health care product is improved.
Further, in some embodiments of the present invention, in the preparation process of the lyophilized powder of pilose antler blood, before the frozen pilose antler blood is subjected to low-temperature ultrasonic pyrolysis, the pilose antler blood is mixed with white spirit according to a weight ratio of 2:5 to obtain a pilose antler blood solution, then active water is added to the mixture to be stirred and emulsified, the weight ratio of the active water to the pilose antler blood solution is 1:3, viscous pilose antler blood is obtained after emulsification, the viscous pilose antler blood is sent to a crusher to be crushed, and the crushed viscous pilose antler blood is sent to a material tray of a freeze dryer to be subjected to freezing treatment. By processing the antler blood in this way, the nutrient substances in the antler blood can be fully exposed, which is more beneficial for the absorption of eaters and improves the edible effectiveness of the antler blood freeze-dried powder buccal tablets.
Further, in some embodiments of the present invention, the above active water preparation process is: adding an activating agent into distilled water, and mixing by ultrasonic vibration, wherein the weight ratio of the activating agent to the distilled water is as follows: 5-10:300. Such activated water is healthier and effectively exposes the nutritional costs of the deer antler blood.
Further, in some embodiments of the present invention, the activator is a sucrose ester activator. The activator is selected to avoid influencing the effects of each component in the pilose antler blood freeze-dried powder buccal tablet, and simultaneously, the nutrient substances in the pilose antler blood are easier to absorb.
Further, in some embodiments of the present invention, in the processing of the auxiliary materials, the drying temperature is 35 to 65 ℃ and the drying time is 30 to 80 min. Therefore, all auxiliary materials in the pilose antler blood freeze-dried powder buccal tablet are more sanitary and healthy, and the nutritional ingredients of the pilose antler blood freeze-dried powder buccal tablet cannot be damaged.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
Preparing antler blood freeze-dried powder: mixing frozen deer antler blood with white spirit according to the weight ratio of 2:5 before carrying out low-temperature ultrasonic cracking on the frozen deer antler blood to obtain a deer antler blood solution, adding active water, mixing, stirring and emulsifying, wherein the weight ratio of the active water to the deer antler blood solution is 1:3, emulsifying to obtain viscous deer antler blood, feeding the viscous deer antler blood into a crusher for crushing, feeding the crushed sticky deer antler blood into a material tray of a freeze dryer for freezing treatment, carrying out low-temperature ultrasonic cracking on the frozen deer antler blood, putting the cracked deer antler blood into a freeze drying device for freeze drying treatment, and then putting the freeze-dried deer antler blood into an ultramicro crusher for ultramicro crushing to obtain freeze-dried deer antler blood powder;
Adding an activating agent into the distilled water, ultrasonically vibrating and mixing, adding the activating agent into the distilled water, ultrasonically vibrating and mixing, wherein the weight ratio of the activating agent to the distilled water is as follows: 5:300, wherein the activating agent is a sucrose ester activating agent;
Auxiliary material treatment: respectively cleaning and drying fructus Hippophae, coreopsis tinctoria, Glycyrrhrizae radix, fructus Siraitiae Grosvenorii, semen Sesami Niger, fructus Jujubae, Poria and fructus Gardeniae, and respectively micronizing in micronizer to obtain fructus Hippophae powder, herba Centellae powder, Glycyrrhrizae radix powder, fructus Siraitiae Grosvenorii powder, semen Sesami Niger powder, fructus Jujubae powder, Poria powder and fructus Gardeniae powder, wherein the drying temperature is 35 deg.C, and the drying time is 30 min;
Mixing, granulating and tabletting: mixing the prepared antler blood freeze-dried powder, sea buckthorn powder, snow inulin, liquorice powder, momordica grosvenori powder, black sesame powder, red date powder, tuckahoe powder and gardenia powder according to the following weight parts: 60 parts of pilose antler blood freeze-dried powder, 8 parts of sea buckthorn, 8 parts of snow chrysanthemum, 8 parts of liquorice, 6 parts of momordica grosvenori, 6 parts of black sesame, 4 parts of red date, 4 parts of poria cocos and 4 parts of gardenia, and then 4 parts of flavoring agent and 1 part of adhesive are added to be mixed, and the mixture is added into a granulator to be granulated, and then tabletting is carried out by a tablet machine to obtain the pilose antler blood freeze-dried powder buccal tablet; the content of sanguis Cervi lyophilized powder in the tablet is 0.1 g.
the correctant is selected from stevioside, sucralose, sucrose, xylitol, fructo-oligosaccharide, malto-oligosaccharide, glycyrrhizin, L-arabinose and citric acid;
The adhesive is prepared by mixing starch slurry and dextrin slurry.
Example 2
Preparing antler blood freeze-dried powder: mixing frozen deer antler blood with white spirit according to the weight ratio of 2:5 before carrying out low-temperature ultrasonic cracking on the frozen deer antler blood to obtain a deer antler blood solution, adding active water, mixing, stirring and emulsifying, wherein the weight ratio of the active water to the deer antler blood solution is 1:3, emulsifying to obtain viscous deer antler blood, feeding the viscous deer antler blood into a crusher for crushing, feeding the crushed sticky deer antler blood into a material tray of a freeze dryer for freezing treatment, carrying out low-temperature ultrasonic cracking on the frozen deer antler blood, putting the cracked deer antler blood into a freeze drying device for freeze drying treatment, and then putting the freeze-dried deer antler blood into an ultramicro crusher for ultramicro crushing to obtain freeze-dried deer antler blood powder;
Adding an activating agent into the distilled water, ultrasonically vibrating and mixing, adding the activating agent into the distilled water, ultrasonically vibrating and mixing, wherein the weight ratio of the activating agent to the distilled water is as follows: 10:300, wherein the activating agent is a sucrose ester activating agent;
Auxiliary material treatment: respectively cleaning and drying fructus Hippophae, coreopsis tinctoria, Glycyrrhrizae radix, fructus Siraitiae Grosvenorii, semen Sesami Niger, fructus Jujubae, Poria and fructus Gardeniae, and respectively micronizing in micronizer to obtain fructus Hippophae powder, herba Centellae powder, Glycyrrhrizae radix powder, fructus Siraitiae Grosvenorii powder, semen Sesami Niger powder, fructus Jujubae powder, Poria powder and fructus Gardeniae powder, wherein the drying temperature is 65 deg.C, and the drying time is 80 min;
Mixing, granulating and tabletting: mixing the prepared antler blood freeze-dried powder, sea buckthorn powder, snow inulin, liquorice powder, momordica grosvenori powder, black sesame powder, red date powder, tuckahoe powder and gardenia powder according to the following weight parts: 80 parts of pilose antler blood freeze-dried powder, 16 parts of sea buckthorn, 16 parts of snow chrysanthemum, 16 parts of liquorice, 12 parts of momordica grosvenori, 12 parts of black sesame, 8 parts of red date, 8 parts of poria cocos and 8 parts of gardenia, and then 8 parts of flavoring agent and 3 parts of adhesive are added to be mixed, added into a granulator to be granulated, and then tabletted by a tabletting machine to obtain the pilose antler blood freeze-dried powder buccal tablet; the content of sanguis Cervi lyophilized powder in the tablet is 0.2 g.
the flavoring agent is prepared by mixing stevioside, xylitol, fructo-oligosaccharide, malto-oligosaccharide, glycyrrhizin, L-arabinose and citric acid;
The adhesive is selected from starch slurry and microcrystalline cellulose.
Example 3
Preparing antler blood freeze-dried powder: mixing frozen deer antler blood with white spirit according to the weight ratio of 2:5 before carrying out low-temperature ultrasonic cracking on the frozen deer antler blood to obtain a deer antler blood solution, adding active water, mixing, stirring and emulsifying, wherein the weight ratio of the active water to the deer antler blood solution is 1:3, emulsifying to obtain viscous deer antler blood, feeding the viscous deer antler blood into a crusher for crushing, feeding the crushed sticky deer antler blood into a material tray of a freeze dryer for freezing treatment, carrying out low-temperature ultrasonic cracking on the frozen deer antler blood, putting the cracked deer antler blood into a freeze drying device for freeze drying treatment, and then putting the freeze-dried deer antler blood into an ultramicro crusher for ultramicro crushing to obtain freeze-dried deer antler blood powder;
Adding an activating agent into the distilled water, ultrasonically vibrating and mixing, adding the activating agent into the distilled water, ultrasonically vibrating and mixing, wherein the weight ratio of the activating agent to the distilled water is as follows: 8:300, wherein the activating agent is a sucrose ester activating agent;
Auxiliary material treatment: respectively cleaning and drying fructus Hippophae, coreopsis tinctoria, Glycyrrhrizae radix, fructus Siraitiae Grosvenorii, semen Sesami Niger, fructus Jujubae, Poria and fructus Gardeniae, and respectively micronizing in micronizer to obtain fructus Hippophae powder, herba Centellae powder, Glycyrrhrizae radix powder, fructus Siraitiae Grosvenorii powder, semen Sesami Niger powder, fructus Jujubae powder, Poria powder and fructus Gardeniae powder, wherein the drying temperature is 50 deg.C, and the drying time is 55 min;
Mixing, granulating and tabletting: mixing the prepared antler blood freeze-dried powder, sea buckthorn powder, snow inulin, liquorice powder, momordica grosvenori powder, black sesame powder, red date powder, tuckahoe powder and gardenia powder according to the following weight parts: 70 parts of pilose antler blood freeze-dried powder, 12 parts of sea buckthorn, 12 parts of snow chrysanthemum, 12 parts of liquorice, 9 parts of momordica grosvenori, 9 parts of black sesame, 6 parts of red date, 6 parts of poria cocos and 6 parts of gardenia, and then 6 parts of flavoring agent and 2 parts of adhesive are added to be mixed, added into a granulator to be granulated, and then tabletted by a tabletting machine to obtain the pilose antler blood freeze-dried powder buccal tablet; the content of sanguis Cervi lyophilized powder in the tablet is 0.15 g.
the flavoring agent is prepared by mixing sweet xylitol, fructo-oligosaccharide, malto-oligosaccharide, glycyrrhizin, L-arabinose and citric acid;
The adhesive is selected from starch slurry.
Example 4
Preparing antler blood freeze-dried powder: mixing frozen deer antler blood with white spirit according to the weight ratio of 2:5 before carrying out low-temperature ultrasonic cracking on the frozen deer antler blood to obtain a deer antler blood solution, adding active water, mixing, stirring and emulsifying, wherein the weight ratio of the active water to the deer antler blood solution is 1:3, emulsifying to obtain viscous deer antler blood, feeding the viscous deer antler blood into a crusher for crushing, feeding the crushed sticky deer antler blood into a material tray of a freeze dryer for freezing treatment, carrying out low-temperature ultrasonic cracking on the frozen deer antler blood, putting the cracked deer antler blood into a freeze drying device for freeze drying treatment, and then putting the freeze-dried deer antler blood into an ultramicro crusher for ultramicro crushing to obtain freeze-dried deer antler blood powder;
Adding an activating agent into the distilled water, ultrasonically vibrating and mixing, adding the activating agent into the distilled water, ultrasonically vibrating and mixing, wherein the weight ratio of the activating agent to the distilled water is as follows: 6:300, wherein the activating agent is a sucrose ester activating agent;
Auxiliary material treatment: respectively cleaning and drying fructus Hippophae, coreopsis tinctoria, Glycyrrhrizae radix, fructus Siraitiae Grosvenorii, semen Sesami Niger, fructus Jujubae, Poria and fructus Gardeniae, and respectively micronizing in micronizer to obtain fructus Hippophae powder, herba Centellae powder, Glycyrrhrizae radix powder, fructus Siraitiae Grosvenorii powder, semen Sesami Niger powder, fructus Jujubae powder, Poria powder and fructus Gardeniae powder, wherein the drying temperature is 40 deg.C, and the drying time is 70 min;
Mixing, granulating and tabletting: mixing the prepared antler blood freeze-dried powder, sea buckthorn powder, snow inulin, liquorice powder, momordica grosvenori powder, black sesame powder, red date powder, tuckahoe powder and gardenia powder according to the following weight parts: 65 parts of pilose antler blood freeze-dried powder, 10 parts of sea buckthorn, 10 parts of snow chrysanthemum, 10 parts of liquorice, 7 parts of momordica grosvenori, 7 parts of black sesame, 5 parts of red date, 5 parts of poria cocos and 5 parts of gardenia, and then adding 5 parts of flavoring agent and 3 parts of adhesive to mix, adding the mixture into a granulator to granulate, and then tabletting by using a tablet machine to obtain the pilose antler blood freeze-dried powder buccal tablet; the content of sanguis Cervi lyophilized powder in the tablet is 0.18 g.
The flavoring agent is prepared by mixing stevioside, sucralose, sucrose, xylitol and sodium citrate;
The binder is selected from dextrin pulp and microcrystalline cellulose.
Example 5
Preparing antler blood freeze-dried powder: mixing frozen deer antler blood with white spirit according to the weight ratio of 2:5 before carrying out low-temperature ultrasonic cracking on the frozen deer antler blood to obtain a deer antler blood solution, adding active water, mixing, stirring and emulsifying, wherein the weight ratio of the active water to the deer antler blood solution is 1:3, emulsifying to obtain viscous deer antler blood, feeding the viscous deer antler blood into a crusher for crushing, feeding the crushed sticky deer antler blood into a material tray of a freeze dryer for freezing treatment, carrying out low-temperature ultrasonic cracking on the frozen deer antler blood, putting the cracked deer antler blood into a freeze drying device for freeze drying treatment, and then putting the freeze-dried deer antler blood into an ultramicro crusher for ultramicro crushing to obtain freeze-dried deer antler blood powder;
Adding an activating agent into the distilled water, ultrasonically vibrating and mixing, adding the activating agent into the distilled water, ultrasonically vibrating and mixing, wherein the weight ratio of the activating agent to the distilled water is as follows: 9:300, wherein the activating agent is a sucrose ester activating agent;
Auxiliary material treatment: respectively cleaning and drying fructus Hippophae, coreopsis tinctoria, Glycyrrhrizae radix, fructus Siraitiae Grosvenorii, semen Sesami Niger, fructus Jujubae, Poria and fructus Gardeniae, and respectively micronizing in micronizer to obtain fructus Hippophae powder, herba Centellae powder, Glycyrrhrizae radix powder, fructus Siraitiae Grosvenorii powder, semen Sesami Niger powder, fructus Jujubae powder, Poria powder and fructus Gardeniae powder, wherein the drying temperature is 55 deg.C, and the drying time is 45 min;
Mixing, granulating and tabletting: mixing the prepared antler blood freeze-dried powder, sea buckthorn powder, snow inulin, liquorice powder, momordica grosvenori powder, black sesame powder, red date powder, tuckahoe powder and gardenia powder according to the following weight parts: 45 parts of pilose antler blood freeze-dried powder, 14 parts of sea buckthorn, 14 parts of snow chrysanthemum, 14 parts of liquorice, 11 parts of momordica grosvenori, 11 parts of black sesame, 7 parts of red date, 7 parts of poria cocos and 7 parts of gardenia, and then 7 parts of flavoring agent and 1 part of adhesive are added to be mixed, and the mixture is added into a granulator to be granulated, and then tabletting is carried out by a tablet machine to obtain the pilose antler blood freeze-dried powder buccal tablet; the content of sanguis Cervi lyophilized powder in the tablet is 0.12 g.
The flavoring agent is prepared by mixing stevioside and sodium citrate;
The adhesive is selected from starch slurry and microcrystalline cellulose.
Example of clinical test
The inventor collects the age of 120 volunteers from 22 to 45 years in 2019, 5 months to 2020 and 1 month, wherein 61 male volunteers and 59 female volunteers all suffer from basic diseases such as deficiency of kidney and have poor immunity; 120 volunteers were randomly divided into a treatment group and a control group, wherein 60 individuals were used in the experimental group and 60 individuals were used in the control group, and the lyophilized powder buccal tablets of pilose antler blood prepared in experimental examples 1-5 were used in the volunteers in the experimental group, and the commercially available health products of pilose antler blood were used in the volunteers in the control group.
After 30 consecutive days, the conditions of the volunteers of the experimental group and the control group are shown in Table 1:
TABLE 1
| Group (number of people) | Deficiency of the kidney (number of people) | Immunological competence (number of people) | Fire (number of people) | Recovery (number of people) |
| Experiment group (60) | 2 | 1 | 0 | 58 |
| Control group (60) | 1 | 58 | 21 | 1 |
From the results of table 1, it can be seen that: the pilose antler blood freeze-dried powder buccal tablet provided by the invention not only improves sub-health conditions of deficiency of kidney and poor immunity of human bodies, but also has mild tonifying property and is safer and healthier to use.
In summary, the antler blood freeze-dried powder buccal tablet and the preparation method thereof provided by the invention have at least the following beneficial effects:
The components are as follows by weight: 60-80 parts of pilose antler blood freeze-dried powder, 8-16 parts of sea buckthorn, 8-16 parts of snow chrysanthemum, 8-16 parts of liquorice, 6-12 parts of momordica grosvenori, 6-12 parts of black sesame, 4-8 parts of red date, 4-8 parts of poria cocos, 4-8 parts of gardenia, 4-8 parts of flavoring agent and 1-3 parts of adhesive are combined, so that the pilose antler blood freeze-dried powder is good in taste, and the sea buckthorn, the snow chrysanthemum, the momordica grosvenori and the gardenia are combined with the pilose antler blood freeze-dried powder, so that dryness of the pilose antler blood freeze-dried powder buccal tablet is reduced, the buccal tablet is mild in tonifying property, and is.
The antler blood freeze-dried powder buccal tablet prepared by the method can simply prepare antler blood freeze-dried powder in the antler blood freeze-dried powder preparation process, and enables nutrient substances in the antler blood to be absorbed more easily; in the auxiliary material treatment process, the auxiliary materials are crushed by an ultrafine crusher to be ultrafine powder, so that the taking feeling is better; then mixing, granulating and tabletting to obtain the antler blood freeze-dried powder buccal tablet which is convenient to carry and eat.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Claims (10)
1. A pilose antler blood freeze-dried powder buccal tablet is characterized in that: the paint comprises the following components in parts by weight: 60-80 parts of pilose antler blood freeze-dried powder, 8-16 parts of sea buckthorn, 8-16 parts of snow chrysanthemum, 8-16 parts of liquorice, 6-12 parts of momordica grosvenori, 6-12 parts of black sesame, 4-8 parts of red dates, 4-8 parts of poria cocos, 4-8 parts of gardenia, 4-8 parts of flavoring agents and 1-3 parts of adhesives.
2. The antler blood freeze-dried powder buccal tablet according to claim 1, which is characterized in that: the paint comprises the following components in parts by weight: 70 parts of pilose antler blood freeze-dried powder, 12 parts of sea buckthorn, 12 parts of snow chrysanthemum, 12 parts of liquorice, 9 parts of momordica grosvenori, 9 parts of black sesame, 6 parts of red date, 6 parts of poria cocos, 6 parts of gardenia, 6 parts of flavoring agent and 2 parts of adhesive.
3. the pilose antler blood freeze-dried powder buccal tablet according to any one of claims 1 or 2, characterized in that the flavoring agent is one or a mixture of more of stevioside, sucralose, sucrose, xylitol, fructo-oligosaccharide, malto-oligosaccharide, glycyrrhizin, L-arabinose, citric acid or sodium citrate.
4. The lyophilized cornu Cervi Pantotrichum blood powder buccal tablet of any one of claims 1 or 2, wherein: the adhesive is one or a mixture of starch slurry, dextrin slurry or microcrystalline cellulose.
5. A method for preparing the freeze-dried powder buccal tablet of antler blood as claimed in any one of claims 1 to 4, which is characterized in that: the method comprises the following steps:
Preparing antler blood freeze-dried powder: carrying out low-temperature ultrasonic pyrolysis on frozen antler blood, placing the pyrolyzed antler blood into a freeze drying device for freeze drying treatment, and then placing the freeze-dried antler blood into an ultramicro pulverizer for ultramicro pulverization to obtain antler blood freeze-dried powder;
Auxiliary material treatment: cleaning and drying fructus Hippophae, coreopsis tinctoria, Glycyrrhrizae radix, fructus Siraitiae Grosvenorii, semen Sesami Niger, fructus Jujubae, Poria and fructus Gardeniae, respectively, and micronizing in micronizer to obtain fructus Hippophae powder, herba Centellae powder, Glycyrrhrizae radix powder, fructus Siraitiae Grosvenorii powder, semen Sesami Niger powder, fructus Jujubae powder, Poria powder and fructus Gardeniae powder;
Mixing, granulating and tabletting: mixing the prepared antler blood freeze-dried powder, sea buckthorn powder, snow inulin, liquorice powder, momordica grosvenori powder, black sesame powder, red date powder, tuckahoe powder and gardenia powder according to the following weight parts: 60-80 parts of antler blood freeze-dried powder, 8-16 parts of sea buckthorn, 8-16 parts of snow chrysanthemum, 8-16 parts of liquorice, 6-12 parts of momordica grosvenori, 6-12 parts of black sesame, 4-8 parts of red date, 4-8 parts of poria cocos, 4-8 parts of gardenia, 4-8 parts of flavoring agent and 1-3 parts of adhesive are added, mixed, added into a granulator for granulation, and then tabletted by a tabletting machine to obtain the antler blood freeze-dried powder buccal tablet.
6. The lyophilized cornu Cervi Pantotrichum blood powder buccal tablet of claim 5, which is characterized in that: the content of sanguis Cervi lyophilized powder in each tablet is 0.1-0.2 g.
7. The lyophilized cornu Cervi Pantotrichum blood powder buccal tablet of claim 5, which is characterized in that: in the preparation process of the freeze-dried powder of the pilose antler blood, before the frozen pilose antler blood is subjected to low-temperature ultrasonic pyrolysis, the pilose antler blood is mixed with white spirit according to the weight ratio of 2:5 to obtain a pilose antler blood solution, then active water is added to be mixed and stirred for emulsification, the weight ratio of the active water to the pilose antler blood solution is 1:3, viscous pilose antler blood is obtained after emulsification, the viscous pilose antler blood is sent to a crusher for crushing, and the crushed pilose antler blood is sent to a material tray of a freeze dryer for freezing treatment.
8. The antler blood freeze-dried powder buccal tablet according to claim 7, which is characterized in that: the preparation process of the active water comprises the following steps: adding an activating agent into distilled water, and mixing by ultrasonic vibration, wherein the weight ratio of the activating agent to the distilled water is as follows: 5-10:300.
9. The lyophilized cornu Cervi Pantotrichum blood powder buccal tablet of claim 8, which is characterized in that: the activating agent is a sucrose ester activating agent.
10. The lyophilized cornu Cervi Pantotrichum blood powder buccal tablet of claim 6, which is characterized in that: in the auxiliary material treatment, the drying temperature is 35-65 ℃, and the drying time is 30-80 min.
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1401330A (en) * | 2002-09-05 | 2003-03-12 | 新疆香巴拉食品有限公司 | Buccal red deer horn tablet |
| CN1911115A (en) * | 2006-08-15 | 2007-02-14 | 武生禄 | Four-in-one health-care beverage |
| CN103844158A (en) * | 2012-12-07 | 2014-06-11 | 牛彩风 | Jujube-cornu cervi oral tablet and preparation method thereof |
| CN105011161A (en) * | 2015-07-01 | 2015-11-04 | 陈钢 | Pilose antler blood freeze-dried powder buccal tablets |
| CN107125750A (en) * | 2017-07-13 | 2017-09-05 | 山丹县福鹿农牧科技有限公司 | A kind of antler freeze-dried powder preparation technology |
| CN108378308A (en) * | 2018-03-26 | 2018-08-10 | 吉林省金鹿药业有限公司 | A kind of deer blood double color plate health food and preparation method thereof |
| CN110313532A (en) * | 2019-08-07 | 2019-10-11 | 西安文理学院 | A kind of pilose antler beauty treatment mind easing tea and preparation method thereof |
-
2020
- 2020-03-31 CN CN202010245866.4A patent/CN111418829A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1401330A (en) * | 2002-09-05 | 2003-03-12 | 新疆香巴拉食品有限公司 | Buccal red deer horn tablet |
| CN1911115A (en) * | 2006-08-15 | 2007-02-14 | 武生禄 | Four-in-one health-care beverage |
| CN103844158A (en) * | 2012-12-07 | 2014-06-11 | 牛彩风 | Jujube-cornu cervi oral tablet and preparation method thereof |
| CN105011161A (en) * | 2015-07-01 | 2015-11-04 | 陈钢 | Pilose antler blood freeze-dried powder buccal tablets |
| CN107125750A (en) * | 2017-07-13 | 2017-09-05 | 山丹县福鹿农牧科技有限公司 | A kind of antler freeze-dried powder preparation technology |
| CN108378308A (en) * | 2018-03-26 | 2018-08-10 | 吉林省金鹿药业有限公司 | A kind of deer blood double color plate health food and preparation method thereof |
| CN110313532A (en) * | 2019-08-07 | 2019-10-11 | 西安文理学院 | A kind of pilose antler beauty treatment mind easing tea and preparation method thereof |
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