CN111417653A - Cd47抗原结合分子 - Google Patents

Cd47抗原结合分子 Download PDF

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Publication number
CN111417653A
CN111417653A CN201880071849.4A CN201880071849A CN111417653A CN 111417653 A CN111417653 A CN 111417653A CN 201880071849 A CN201880071849 A CN 201880071849A CN 111417653 A CN111417653 A CN 111417653A
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amino acid
acid sequence
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CN201880071849.4A
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Chinese (zh)
Inventor
J·D·博伊德-柯克普
D·萨克
P·英格拉姆
吴志浩
K·帕兹基维奇
P·布劳尔
关思宇
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Hummingbird Biotechnology Pte Ltd
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Hummingbird Bioscience Holdings Ltd
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Priority claimed from GBGB1718101.7A external-priority patent/GB201718101D0/en
Priority claimed from GBGB1720426.4A external-priority patent/GB201720426D0/en
Priority claimed from GBGB1720425.6A external-priority patent/GB201720425D0/en
Application filed by Hummingbird Bioscience Holdings Ltd filed Critical Hummingbird Bioscience Holdings Ltd
Publication of CN111417653A publication Critical patent/CN111417653A/zh
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity

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  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201880071849.4A 2017-11-01 2018-11-01 Cd47抗原结合分子 Pending CN111417653A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB1718101.7A GB201718101D0 (en) 2017-11-01 2017-11-01 CD47 and CD33 Antigen-binding molecules
GB1718101.7 2017-11-01
GB1720425.6 2017-12-07
GB1720426.4 2017-12-07
GBGB1720426.4A GB201720426D0 (en) 2017-12-07 2017-12-07 CD47 and BCMA antigen-binding molecules
GBGB1720425.6A GB201720425D0 (en) 2017-12-07 2017-12-07 CD47 and CD33 antigen-binding molecules
PCT/EP2018/079931 WO2019086573A1 (en) 2017-11-01 2018-11-01 Cd47 antigen-binding molecules

Publications (1)

Publication Number Publication Date
CN111417653A true CN111417653A (zh) 2020-07-14

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CN201880071849.4A Pending CN111417653A (zh) 2017-11-01 2018-11-01 Cd47抗原结合分子

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US (2) US20220298254A1 (https=)
EP (1) EP3704157A1 (https=)
JP (1) JP2021500926A (https=)
KR (1) KR20200079511A (https=)
CN (1) CN111417653A (https=)
AU (1) AU2018358004A1 (https=)
CA (1) CA3080860A1 (https=)
SG (1) SG11202003943YA (https=)
WO (1) WO2019086573A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
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WO2023051674A1 (zh) * 2021-09-30 2023-04-06 正大天晴药业集团南京顺欣制药有限公司 联合治疗血液肿瘤的抗cd47抗体
CN116004636A (zh) * 2023-01-10 2023-04-25 广西师范大学 一种不结合红细胞的差异化cd47核酸适体及其应用

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CN111417653A (zh) 2017-11-01 2020-07-14 蜂鸟生物科技控股私人有限公司 Cd47抗原结合分子
CN114761041A (zh) 2019-07-16 2022-07-15 吉利德科学公司 Hiv疫苗及其制备和使用方法
CN112969715B (zh) * 2019-08-21 2022-03-18 和铂医药(上海)有限责任公司 一种抗cd47抗原结合蛋白及其应用
CN112442123B (zh) * 2019-09-03 2022-08-23 中山康方生物医药有限公司 抗cd47的单克隆抗体及其用途
CN114555123B (zh) 2019-10-18 2024-04-02 四十七公司 用于治疗骨髓增生异常综合征和急性髓系白血病的联合疗法
KR20220091576A (ko) 2019-10-31 2022-06-30 포티 세븐, 인코포레이티드 혈액암의 항-cd47 및 항-cd20 기반 치료
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US12091681B2 (en) 2020-03-27 2024-09-17 Mendus B.V. Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy
KR20220163991A (ko) * 2020-04-02 2022-12-12 치아타이 티안큉 파마수티컬 그룹 주식회사 Cd47에 결합하는 항원-결합 폴리펩타이드 및 이의 용도
CN116133679A (zh) 2020-06-30 2023-05-16 门德斯有限公司 白血病衍生细胞在卵巢癌疫苗中的用途
KR102557016B1 (ko) * 2020-09-22 2023-07-20 비피진 주식회사 암 치료를 위한 cd47 바인더 및 리포좀 복합체
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TWI876305B (zh) 2022-04-05 2025-03-11 美商基利科學股份有限公司 用於治療結腸直腸癌之組合療法
WO2023205719A1 (en) 2022-04-21 2023-10-26 Gilead Sciences, Inc. Kras g12d modulating compounds
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CN120882725A (zh) 2023-04-11 2025-10-31 吉利德科学公司 Kras调节化合物
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023051674A1 (zh) * 2021-09-30 2023-04-06 正大天晴药业集团南京顺欣制药有限公司 联合治疗血液肿瘤的抗cd47抗体
CN116004636A (zh) * 2023-01-10 2023-04-25 广西师范大学 一种不结合红细胞的差异化cd47核酸适体及其应用
CN116004636B (zh) * 2023-01-10 2024-03-12 广西师范大学 一种不结合红细胞的差异化cd47核酸适体及其应用

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SG11202003943YA (en) 2020-05-28
WO2019086573A1 (en) 2019-05-09
EP3704157A1 (en) 2020-09-09
KR20200079511A (ko) 2020-07-03
CA3080860A1 (en) 2019-05-09
US20220356250A1 (en) 2022-11-10
AU2018358004A1 (en) 2020-05-28
US11685789B2 (en) 2023-06-27
US20220298254A1 (en) 2022-09-22
JP2021500926A (ja) 2021-01-14

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