CN111407857A - Method for extracting water-soluble red yeast rice - Google Patents
Method for extracting water-soluble red yeast rice Download PDFInfo
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- CN111407857A CN111407857A CN202010215914.5A CN202010215914A CN111407857A CN 111407857 A CN111407857 A CN 111407857A CN 202010215914 A CN202010215914 A CN 202010215914A CN 111407857 A CN111407857 A CN 111407857A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
Abstract
The invention provides a method for extracting water-soluble red yeast rice, which comprises the following process steps of selecting high-quality non-pollution transgenic rice as a raw material, sequentially adding water, soaking at room temperature and draining, putting the processed raw material into a sterilization pot for heating sterilization, taking out the raw material after sterilization, cooling, inoculating a red yeast rice strain under an aseptic condition for fermentation culture to obtain a fermentation culture, sterilizing, drying and crushing the fermentation culture to obtain functional red yeast rice, putting the functional red yeast rice into a solvent for wetting, then adding the solvent for soaking at a constant temperature, filtering to obtain an extracting solution, adding a proper amount of Tween 80 emulsifier, a proper amount of maltodextrin and β cyclodextrin into the extracting solution, putting the obtained extracting solution into a rotary evaporator for concentration, putting the concentrated extracting solution into an oven for drying, and obtaining the water-soluble red yeast rice.
Description
[ technical field ] A method for producing a semiconductor device
The invention relates to the technical field of red yeast preparation, in particular to a method for extracting water-soluble red yeast.
[ background of the invention ]
Red yeast rice is also called red yeast rice and red yeast, is a purple red rice yeast which is prepared by fermenting rice serving as a main raw material through monascus, and has medicinal and edible values from ancient times. The compendium of materia medica records that red yeast is mainly used for promoting digestion and activating blood, strengthening spleen and drying stomach, treating red and white dysentery and diarrhea, brewing blood and promoting blood circulation, postpartum lochiorrhea and the like. The red yeast rice can be divided into three types according to the application, the first type is the red yeast rice for coloring, the red yeast rice is divided into specifications by taking different color values as indexes, is mainly used in meat products, is a natural pigment, and is widely used in various countries in the world; the second is red yeast for fermenting and brewing wine; the third is red yeast rice for health care or medicine, also called functional red yeast rice. The functional red yeast rice is a pure natural biological product with the effects of reducing blood cholesterol, reducing blood sugar, reducing blood pressure and preventing cancer, and comprises various bioactive components such as moraxelin K, ergosterol, gamma-aminobutyric acid, natural plant hormones and the like, wherein the content of the moraxelin K determines the quality of the effect of the functional red yeast rice. At present, functional red yeast rice products are poor in water solubility and cannot be directly added into liquid food for use, the application range of the functional red yeast rice is greatly limited, and particularly, the method for extracting the water-soluble red yeast rice is applied to liquid products.
[ summary of the invention ]
The invention aims to solve the problems in the prior art and provides an extraction method of water-soluble red yeast rice.
In order to realize the purpose, the invention provides an extraction method of water-soluble red yeast rice, which sequentially comprises the following process steps:
step a, selecting high-quality non-pollution non-transgenic rice as a raw material, and sequentially adding water, soaking at room temperature and draining the raw material;
b, putting the raw materials treated in the step a into a sterilization pot for heating sterilization, taking out the raw materials after sterilization, cooling, inoculating the monascus strains under the aseptic condition, and performing fermentation culture for a period of time to obtain a fermentation culture;
step c, sterilizing, drying and crushing the fermentation culture to obtain functional red yeast rice;
d, putting the functional red yeast rice into a solvent for wetting;
step e, adding a solvent into the wetted functional red yeast rice, soaking at constant temperature, and filtering to obtain an extracting solution;
step f, adding a proper amount of Tween 80 emulsifier, a proper amount of maltodextrin and β cyclodextrin into the extracting solution;
step g, placing the extracting solution obtained in the step f in a rotary evaporator for concentration treatment;
and h, placing the concentrated extracting solution in an oven for drying to finally obtain the water-soluble red yeast rice.
Preferably, in the step a, the raw materials are sequentially subjected to water adding, room-temperature soaking and draining treatment, so that the water content of the raw materials reaches 45-55 wt%.
Preferably, the raw materials after treatment are placed into a sterilization pot in the step b, the raw materials are heated and sterilized for 30-100min at the temperature of 120-150 ℃, the raw materials are taken out and cooled to be below 35 ℃, the monascus strains are inoculated under the aseptic condition, the inoculation amount is 10-30 wt%, and the step fermentation culture is carried out.
Preferably, the step b of the step b comprises 20-70 days of staged fermentation culture, 30-45 ℃ of culture temperature in the first 7 days and 20-25 ℃ of culture temperature in the later period.
Preferably, the functional red yeast rice is placed into a 70-90% ethanol solution to be wetted for 15-60min in the step d.
Preferably, ethanol is adopted for constant-temperature impregnation in the step e, 70-90% ethanol solution which is 8 times of the weight of the functional red yeast rice obtained in the step c is added into the wetted functional red yeast rice, the mixture is immersed for 1-3 hours at the constant temperature of 40-60 ℃, and then is filtered, and filtrate is collected; and c, adding 70-90% ethanol solution which is 6 times of the weight of the functional red yeast rice obtained in the step c into the filtered filter residue, soaking for 1-3 hours at the constant temperature of 40-60 ℃, filtering after soaking, collecting filtrate, and combining the two collected filtrates to obtain an extracting solution.
Preferably, in the step f, Tween 80 emulsifier accounting for 0.8-1.5% of the mass of the extracting solution and maltodextrin accounting for 20-30% of the mass of the extracting solution are added into the extracting solution.
Preferably, in the step f, the content of the moraxelin K in the extracting solution is determined by detecting the extracting solution obtained in the step e, and the mass of the added β cyclodextrin in the extracting solution is the same as the content of the moraxelin K in the extracting solution.
Preferably, in the step f, the pH value of the extracting solution is adjusted to 8.0.
Preferably, in the step h, the concentrated extracting solution is placed in an oven at 45-55 ℃ for drying, and finally the water-soluble red yeast rice is obtained.
The method has the beneficial effects that high-quality non-pollution non-transgenic rice is selected as a raw material, the raw material is subjected to water adding, room-temperature soaking, draining and other treatment, the sterilized red yeast rice is inoculated with red yeast rice strains for fermentation culture, the fermentation culture is subjected to sterilization, drying and crushing to obtain functional red yeast rice, the wet functional red yeast rice is soaked, the extract is obtained through extraction and filtration, a Tween 80 emulsifier, a proper amount of maltodextrin and β cyclodextrin are added into the extract, the concentrate treatment is performed in a rotary evaporator, and the concentrated extract is dried to obtain the water-soluble red yeast rice extract with high Moraxelin K content.
The features and advantages of the present invention will be described in detail by way of examples.
[ detailed description ] embodiments
Example one
The invention relates to a method for extracting water-soluble red yeast rice, which adopts the following process steps: step a, selecting 300g of high-quality non-pollution non-transgenic rice as a raw material, and sequentially adding water, soaking at room temperature and draining to enable the water content of the raw material to reach 45 wt%;
b, putting the raw materials processed in the step a into a sterilization pot, heating and sterilizing at 125 ℃ for 38min, taking out and cooling to below 35 ℃, inoculating 10 wt% of monascus strains under an aseptic condition, fermenting and culturing for 27 days, wherein the culture temperature in the first 7 days is 30 ℃, and then reducing the culture temperature to 20 ℃ for continuous culture for 20 days;
step c, sterilizing, drying and crushing the fermentation culture to obtain the Moraxelin K functional red yeast rice;
d, putting the functional red yeast rice into 75% ethanol with the volume 8 times of the weight of the red yeast rice for wetting for 15 min; adding 800ml of ethanol into every 100g of red yeast rice;
step e, soaking the wetted functional red yeast rice for 1 hour at 40 ℃, filtering the functional red yeast rice, collecting filtrate, soaking the filter residue in 75% ethanol with the volume 6 times of the weight of the red yeast rice for 1 hour at 40 ℃, and filtering to obtain an extracting solution so as to ensure that all the moraxelin K in the functional red yeast rice is extracted;
step f, adding 0.8% of Tween 80 emulsifier, 20% of maltodextrin and β cyclodextrin into the extracting solution, wherein 20% of maltodextrin is used as a matrix, the content ratio of the 0.8% of Tween 80 emulsifier and β cyclodextrin to the Moraxelin K in the extracting solution is 1:1 for embedding, and in order to increase the water solubility of the red yeast rice, adjusting the pH of the extracting solution to 8.0 to completely alkalize the red yeast rice;
step g, placing the obtained extracting solution in a rotary evaporator for concentration treatment;
and h, placing the concentrated extracting solution in a drying oven at 48 ℃ for drying to finally obtain the Moraxelin K water-soluble product.
Example two
The invention relates to a method for extracting water-soluble red yeast rice, which adopts the following process steps:
step a, selecting 600g of high-quality non-pollution non-transgenic rice as a raw material, and sequentially adding water, soaking at room temperature and draining to enable the water content of the raw material to reach 48 wt%;
b, putting the raw materials treated in the step a into a sterilization pot, heating and sterilizing at 130 ℃ for 55min, taking out and cooling to below 35 ℃, inoculating 16 wt% of monascus strains under an aseptic condition, fermenting and culturing for 52 days, wherein the culture temperature in the first 7 days is 38 ℃, and the culture temperature in the later 45 days is 22 ℃;
step c, sterilizing, drying and crushing the fermentation culture to obtain the Moraxelin K functional red yeast rice;
d, putting the functional red yeast rice into 85 percent ethanol with the volume 8 times of the weight of the red yeast rice for wetting for 30 min;
step e, soaking the moistened functional red yeast rice for 2 hours at 50 ℃, then filtering the functional red yeast rice, collecting filtrate, soaking the filter residue for 2 hours at 50 ℃ in 85% ethanol with the volume 6 times of the weight of the red yeast rice, and filtering to obtain an extracting solution so as to ensure that all the moraxelin K in the functional red yeast rice is extracted;
step f, adding 1% of Tween 80 emulsifier, 24% of maltodextrin and β cyclodextrin into the extracting solution, wherein the 24% of maltodextrin is used as a matrix, the content ratio of the 1% of Tween 80 emulsifier, the β of cyclodextrin to the Moraxelin K in the extracting solution is 1:1 for embedding, and in order to increase the water solubility of the red yeast rice, the PH value of the extracting solution is adjusted to 8.0 to completely alkalize the red yeast rice;
step g, placing the obtained extracting solution in a rotary evaporator for concentration treatment;
and h, placing the concentrated extracting solution in a 50 ℃ drying oven for drying to finally obtain the Moraxelin K water-soluble product.
EXAMPLE III
The invention relates to a method for extracting water-soluble red yeast rice, which adopts the following process steps:
step a, selecting 1000g of high-quality non-pollution non-transgenic rice as a raw material, and sequentially adding water, soaking at room temperature and draining to enable the water content of the raw material to reach 52 wt%;
b, putting the raw materials treated in the step a into a sterilization pot, heating and sterilizing at 138 ℃ for 60min, taking out and cooling to below 35 ℃, inoculating 24 wt% of monascus strains under an aseptic condition, fermenting and culturing for 65 days, wherein the culture temperature in the first 7 days is 42 ℃, and the culture temperature in the later 58 days is 25 ℃;
step c, sterilizing, drying and crushing the fermentation culture to obtain the Moraxelin K functional red yeast rice;
d, putting the functional red yeast rice into 90% ethanol with the volume 8 times of the weight of the red yeast rice for wetting for 45 min;
step e, soaking the moistened functional red yeast rice at 55 ℃ for 3 hours, then filtering the soaked functional red yeast rice, collecting filtrate, soaking the filter residue in 90% ethanol with the volume 6 times of the weight of the red yeast rice at 55 ℃ for 3 hours, and filtering to obtain an extracting solution so as to ensure that all the moraxelin K in the functional red yeast rice is extracted;
step f, adding 1.4% of Tween 80 emulsifier, 28% of maltodextrin and β of cyclodextrin into the extracting solution, wherein the 1.4% of Tween 80 emulsifier and the 28% of maltodextrin are used as matrixes, the ratio of β of the cyclodextrin to the content of the Moraxelin K in the extracting solution is 1:1, and the pH of the extracting solution is adjusted to 8.0 to fully alkalize the extracting solution in order to increase the water solubility of the red yeast rice;
step g, placing the obtained extracting solution in a rotary evaporator for concentration treatment;
and h, placing the concentrated extracting solution in an oven at 55 ℃ for drying to finally obtain the water-soluble product with the Moraxelin K content.
In the above three examples, the content of functional red koji powder was the highest in example 3.
The products obtained in examples 2 and 3 are dissolved in water, and compared, the color is clear.
The above is only a specific application example of the present invention, and the protection scope of the present invention is not limited in any way. All the technical solutions formed by equivalent transformation or equivalent replacement fall within the protection scope of the present invention.
Claims (10)
1. A method for extracting water-soluble red yeast rice is characterized by comprising the following steps: the method sequentially comprises the following process steps:
step a, selecting high-quality non-pollution non-transgenic rice as a raw material, and sequentially adding water, soaking at room temperature and draining the raw material;
b, putting the raw materials treated in the step a into a sterilization pot for heating sterilization, taking out the raw materials after sterilization, cooling, inoculating the monascus strains under the aseptic condition, and performing fermentation culture for a period of time to obtain a fermentation culture;
step c, sterilizing, drying and crushing the fermentation culture to obtain functional red yeast rice;
d, putting the functional red yeast rice into a solvent for wetting;
step e, adding a solvent into the wetted functional red yeast rice, soaking at constant temperature, and filtering to obtain an extracting solution;
step f, adding a proper amount of Tween 80 emulsifier, a proper amount of maltodextrin and β cyclodextrin into the extracting solution;
step g, placing the extracting solution obtained in the step f in a rotary evaporator for concentration treatment;
and h, placing the concentrated extracting solution in an oven for drying to finally obtain the water-soluble red yeast rice.
2. The method for extracting water-soluble red yeast rice as claimed in claim 1, wherein: in the step a, the raw materials are sequentially added with water, soaked at room temperature and drained to enable the water content to reach 45-55 wt%.
3. The method for extracting water-soluble red yeast rice as claimed in claim 1, wherein: and (b) placing the treated raw materials into a sterilization pot, carrying out heating sterilization at the temperature of 120-150 ℃ for 30-100min, taking out and cooling to the temperature below 35 ℃, inoculating the monascus strains under the aseptic condition, wherein the inoculation amount is 10-30 wt%, and carrying out segmented fermentation culture.
4. The method for extracting water-soluble red yeast rice as claimed in claim 3, wherein: the stage fermentation culture in the step b is 20-70 days, the culture temperature in the first 7 days is 30-45 ℃, and the culture temperature in the later period is 20-25 ℃.
5. The method for extracting water-soluble red yeast rice as claimed in claim 1, wherein: and d, wetting the functional red yeast rice in a 70-90% ethanol solution for 15-60 min.
6. The method for extracting water-soluble red yeast rice as claimed in claim 1, wherein: soaking the functional red yeast rice in ethanol at constant temperature, adding 70-90% ethanol solution which is 8 times of the weight of the functional red yeast rice obtained in the step c into the moistened functional red yeast rice, soaking the functional red yeast rice at constant temperature of 40-60 ℃ for 1-3h, filtering the functional red yeast rice, and collecting filtrate; and c, adding 70-90% ethanol solution which is 6 times of the weight of the functional red yeast rice obtained in the step c into the filtered filter residue, soaking for 1-3 hours at the constant temperature of 40-60 ℃, filtering after soaking, collecting filtrate, and combining the two collected filtrates to obtain an extracting solution.
7. The method for extracting water-soluble red yeast rice as claimed in claim 1, wherein: and f, adding a Tween 80 emulsifier accounting for 0.8-1.5% of the mass of the extracting solution and maltodextrin accounting for 20-30% of the mass of the extracting solution into the extracting solution.
8. The method for extracting water-soluble red yeast rice as claimed in claim 1, wherein in step f, the content of Moraxelin K in the extract is determined by detecting the extract obtained in step e, and β cyclodextrin is added to the extract in a mass same as the content of Moraxelin K in the extract.
9. The method for extracting water-soluble red yeast rice as claimed in claim 1, wherein: in the step f, the pH value of the extracting solution is adjusted to 8.0.
10. The method for extracting water-soluble red yeast rice as claimed in claim 1, wherein: and in the step h, the concentrated extracting solution is placed in an oven with the temperature of 45-55 ℃ for drying, and finally the water-soluble red yeast rice is obtained.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114177254A (en) * | 2021-12-10 | 2022-03-15 | 安发（福建）生物科技有限公司 | Method for improving hygroscopicity of red yeast rice extract |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101407825A (en) * | 2008-10-31 | 2009-04-15 | 江南大学 | Method for producing water-soluble functional red koji powder |
| CN110623206A (en) * | 2019-09-20 | 2019-12-31 | 湖南微著生物科技有限公司 | Preparation method of lovastatin-rich functional red yeast rice |
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2020
- 2020-03-25 CN CN202010215914.5A patent/CN111407857A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101407825A (en) * | 2008-10-31 | 2009-04-15 | 江南大学 | Method for producing water-soluble functional red koji powder |
| CN110623206A (en) * | 2019-09-20 | 2019-12-31 | 湖南微著生物科技有限公司 | Preparation method of lovastatin-rich functional red yeast rice |
Non-Patent Citations (1)
| Title |
|---|
| 陈运中: "功能性红曲色素发酵工艺研究", 《食品科学》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114177254A (en) * | 2021-12-10 | 2022-03-15 | 安发（福建）生物科技有限公司 | Method for improving hygroscopicity of red yeast rice extract |
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