CN111388381A - Cosmetic elsholtzia extract and extraction method thereof - Google Patents
Cosmetic elsholtzia extract and extraction method thereof Download PDFInfo
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- CN111388381A CN111388381A CN202010434575.XA CN202010434575A CN111388381A CN 111388381 A CN111388381 A CN 111388381A CN 202010434575 A CN202010434575 A CN 202010434575A CN 111388381 A CN111388381 A CN 111388381A
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- 241000131458 Elsholtzia Species 0.000 title claims abstract description 23
- 239000002537 cosmetic Substances 0.000 title claims abstract description 21
- 238000000605 extraction Methods 0.000 title abstract description 8
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 claims abstract description 26
- 239000005844 Thymol Substances 0.000 claims abstract description 13
- RECUKUPTGUEGMW-UHFFFAOYSA-N carvacrol Chemical compound CC(C)C1=CC=C(C)C(O)=C1 RECUKUPTGUEGMW-UHFFFAOYSA-N 0.000 claims abstract description 13
- HHTWOMMSBMNRKP-UHFFFAOYSA-N carvacrol Natural products CC(=C)C1=CC=C(C)C(O)=C1 HHTWOMMSBMNRKP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 235000007746 carvacrol Nutrition 0.000 claims abstract description 13
- WYXXLXHHWYNKJF-UHFFFAOYSA-N isocarvacrol Natural products CC(C)C1=CC=C(O)C(C)=C1 WYXXLXHHWYNKJF-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229960000790 thymol Drugs 0.000 claims abstract description 13
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 claims abstract description 9
- 229930003944 flavone Natural products 0.000 claims abstract description 9
- 150000002212 flavone derivatives Chemical class 0.000 claims abstract description 9
- 235000011949 flavones Nutrition 0.000 claims abstract description 9
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 claims abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 43
- 239000011347 resin Substances 0.000 claims description 29
- 229920005989 resin Polymers 0.000 claims description 29
- 239000007788 liquid Substances 0.000 claims description 24
- 238000000199 molecular distillation Methods 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 13
- 238000001035 drying Methods 0.000 claims description 9
- 239000012535 impurity Substances 0.000 claims description 9
- 238000010298 pulverizing process Methods 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 238000007865 diluting Methods 0.000 claims description 8
- XKMRRTOUMJRJIA-UHFFFAOYSA-N ammonia nh3 Chemical compound N.N XKMRRTOUMJRJIA-UHFFFAOYSA-N 0.000 claims description 7
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
- 239000012528 membrane Substances 0.000 claims description 3
- 229910021529 ammonia Inorganic materials 0.000 claims description 2
- 229910052757 nitrogen Inorganic materials 0.000 claims description 2
- -1 organic acid glycoside Chemical class 0.000 description 8
- 102000004169 proteins and genes Human genes 0.000 description 8
- 108090000623 proteins and genes Proteins 0.000 description 8
- 239000000341 volatile oil Substances 0.000 description 8
- 239000002994 raw material Substances 0.000 description 6
- XADJWCRESPGUTB-UHFFFAOYSA-N apigenin Natural products C1=CC(O)=CC=C1C1=CC(=O)C2=CC(O)=C(O)C=C2O1 XADJWCRESPGUTB-UHFFFAOYSA-N 0.000 description 5
- 235000008714 apigenin Nutrition 0.000 description 5
- 229940117893 apigenin Drugs 0.000 description 5
- 229930003935 flavonoid Natural products 0.000 description 5
- 235000017173 flavonoids Nutrition 0.000 description 5
- 229930182470 glycoside Natural products 0.000 description 5
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 5
- DOUMFZQKYFQNTF-WUTVXBCWSA-N (R)-rosmarinic acid Chemical compound C([C@H](C(=O)O)OC(=O)\C=C\C=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 DOUMFZQKYFQNTF-WUTVXBCWSA-N 0.000 description 4
- CVTZKFWZDBJAHE-UHFFFAOYSA-N [N].N Chemical class [N].N CVTZKFWZDBJAHE-UHFFFAOYSA-N 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 150000002215 flavonoids Chemical class 0.000 description 4
- IQPNAANSBPBGFQ-UHFFFAOYSA-N luteolin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(O)C(O)=C1 IQPNAANSBPBGFQ-UHFFFAOYSA-N 0.000 description 4
- LRDGATPGVJTWLJ-UHFFFAOYSA-N luteolin Natural products OC1=CC(O)=CC(C=2OC3=CC(O)=CC(O)=C3C(=O)C=2)=C1 LRDGATPGVJTWLJ-UHFFFAOYSA-N 0.000 description 4
- 235000009498 luteolin Nutrition 0.000 description 4
- 241001549572 Elsholtzia splendens Species 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 241000717679 Mosla Species 0.000 description 3
- KZNIFHPLKGYRTM-UHFFFAOYSA-N apigenin Chemical compound C1=CC(O)=CC=C1C1=CC(=O)C2=C(O)C=C(O)C=C2O1 KZNIFHPLKGYRTM-UHFFFAOYSA-N 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 238000005265 energy consumption Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000006641 stabilisation Effects 0.000 description 3
- 238000011105 stabilization Methods 0.000 description 3
- WRYLYDPHFGVWKC-UHFFFAOYSA-N 4-terpineol Chemical compound CC(C)C1(O)CCC(C)=CC1 WRYLYDPHFGVWKC-UHFFFAOYSA-N 0.000 description 2
- OXZSUQJHKQOGOK-UHFFFAOYSA-N 5-Isopropyl-2-methylphenol acetate Chemical compound CC(C)C1=CC=C(C)C(OC(C)=O)=C1 OXZSUQJHKQOGOK-UHFFFAOYSA-N 0.000 description 2
- 241001600408 Aphis gossypii Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 2
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- WFMIUXMJJBBOGJ-UHFFFAOYSA-N Thymyl acetate Chemical compound CC(C)C1=CC=C(C)C=C1OC(C)=O WFMIUXMJJBBOGJ-UHFFFAOYSA-N 0.000 description 2
- NVEQFIOZRFFVFW-RGCMKSIDSA-N caryophyllene oxide Chemical compound C=C1CC[C@H]2O[C@]2(C)CC[C@H]2C(C)(C)C[C@@H]21 NVEQFIOZRFFVFW-RGCMKSIDSA-N 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 150000002338 glycosides Chemical class 0.000 description 2
- 238000009776 industrial production Methods 0.000 description 2
- 230000002147 killing effect Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- HFPZCAJZSCWRBC-UHFFFAOYSA-N p-cymene Chemical compound CC(C)C1=CC=C(C)C=C1 HFPZCAJZSCWRBC-UHFFFAOYSA-N 0.000 description 2
- DOUMFZQKYFQNTF-MRXNPFEDSA-N rosemarinic acid Natural products C([C@H](C(=O)O)OC(=O)C=CC=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 DOUMFZQKYFQNTF-MRXNPFEDSA-N 0.000 description 2
- TVHVQJFBWRLYOD-UHFFFAOYSA-N rosmarinic acid Natural products OC(=O)C(Cc1ccc(O)c(O)c1)OC(=Cc2ccc(O)c(O)c2)C=O TVHVQJFBWRLYOD-UHFFFAOYSA-N 0.000 description 2
- QAIPRVGONGVQAS-DUXPYHPUSA-N trans-caffeic acid Chemical compound OC(=O)\C=C\C1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-DUXPYHPUSA-N 0.000 description 2
- FAMPSKZZVDUYOS-OWEBEESNSA-N (1e,4z,8e)-2,6,6,9-tetramethylcycloundeca-1,4,8-triene Chemical compound C\C1=C/CC(C)(C)\C=C/C\C(C)=C\CC1 FAMPSKZZVDUYOS-OWEBEESNSA-N 0.000 description 1
- ACEAELOMUCBPJP-UHFFFAOYSA-N (E)-3,4,5-trihydroxycinnamic acid Natural products OC(=O)C=CC1=CC(O)=C(O)C(O)=C1 ACEAELOMUCBPJP-UHFFFAOYSA-N 0.000 description 1
- WCXDHFDTOYPNIE-RIYZIHGNSA-N (E)-acetamiprid Chemical compound N#C/N=C(\C)N(C)CC1=CC=C(Cl)N=C1 WCXDHFDTOYPNIE-RIYZIHGNSA-N 0.000 description 1
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 description 1
- WRYLYDPHFGVWKC-SNVBAGLBSA-N 4-Terpineol Natural products CC(C)[C@]1(O)CCC(C)=CC1 WRYLYDPHFGVWKC-SNVBAGLBSA-N 0.000 description 1
- IBSREHMXUMOFBB-JFUDTMANSA-N 5u8924t11h Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 IBSREHMXUMOFBB-JFUDTMANSA-N 0.000 description 1
- NVEQFIOZRFFVFW-UHFFFAOYSA-N 9-epi-beta-caryophyllene oxide Natural products C=C1CCC2OC2(C)CCC2C(C)(C)CC21 NVEQFIOZRFFVFW-UHFFFAOYSA-N 0.000 description 1
- 239000005660 Abamectin Substances 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 239000005875 Acetamiprid Substances 0.000 description 1
- 206010063659 Aversion Diseases 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 description 1
- 208000009084 Cold Injury Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 241000311345 Elsholtzia haichowensis Species 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000008017 Hypohidrosis Diseases 0.000 description 1
- 241000207923 Lamiaceae Species 0.000 description 1
- 241000717677 Mosla chinensis Species 0.000 description 1
- ZTHLHHDJRXJGRX-UHFFFAOYSA-N Negletein Chemical compound C=1C(=O)C=2C(O)=C(O)C(OC)=CC=2OC=1C1=CC=CC=C1 ZTHLHHDJRXJGRX-UHFFFAOYSA-N 0.000 description 1
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 1
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 229950008167 abamectin Drugs 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- FAMPSKZZVDUYOS-UHFFFAOYSA-N alpha-Caryophyllene Natural products CC1=CCC(C)(C)C=CCC(C)=CCC1 FAMPSKZZVDUYOS-UHFFFAOYSA-N 0.000 description 1
- 206010002512 anhidrosis Diseases 0.000 description 1
- 230000037001 anhydrosis Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 235000004883 caffeic acid Nutrition 0.000 description 1
- 229940074360 caffeic acid Drugs 0.000 description 1
- RSYBQKUNBFFNDO-UHFFFAOYSA-N caryophyllene oxide Natural products CC1(C)CC2C(=C)CCC3OC3(C)CCC12C RSYBQKUNBFFNDO-UHFFFAOYSA-N 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 235000001368 chlorogenic acid Nutrition 0.000 description 1
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 description 1
- 229940074393 chlorogenic acid Drugs 0.000 description 1
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 description 1
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 description 1
- QAIPRVGONGVQAS-UHFFFAOYSA-N cis-caffeic acid Natural products OC(=O)C=CC1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-UHFFFAOYSA-N 0.000 description 1
- 230000002595 cold damage Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229930182486 flavonoid glycoside Natural products 0.000 description 1
- 150000007955 flavonoid glycosides Chemical class 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- QBNFBHXQESNSNP-UHFFFAOYSA-N humulene Natural products CC1=CC=CC(C)(C)CC=C(/C)CCC1 QBNFBHXQESNSNP-UHFFFAOYSA-N 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000000874 microwave-assisted extraction Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229960001285 quercetin Drugs 0.000 description 1
- 235000005875 quercetin Nutrition 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000000194 supercritical-fluid extraction Methods 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 239000004563 wettable powder Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses an elsholtzia extract for cosmetics and an extraction method, wherein the elsholtzia extract for cosmetics contains: thymol is not less than 7.0 wt%, carvacrol is not less than 4.0 wt%, and total flavone is not less than 3 wt%, wherein the sum of thymol, carvacrol and total flavone is less than 100 wt%. The cosmetics prepared by the elsholtzia extract have stable color and no odor.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to an elsholtzia extract for cosmetics and an extraction method.
Background
Herba Moslae is dry aerial part of Moslachinismax or Mosla chinensis 'Jiiangxiangru' of Labiatae. The former is called Qingxiang hai she, the latter is called Jiang xiang hai she. Collecting and cutting in sunny days when stems and leaves are flourishing and flowers are flourishing in summer, removing impurities, and drying in the shade. It is commonly used for summer-damp common cold, aversion to cold, fever, headache, anhidrosis, abdominal pain, vomiting and diarrhea. The contents of the Chinese pharmacopoeia 2015 and the catalog of used cosmetic raw materials are recorded.
Modern researches show that the main effective components of the elsholtzia comprise volatile oil, flavonoid glycoside, organic acid glycoside and the like, wherein the content of the volatile oil is more than 0.6 percent in pharmacopoeia, the volatile oil mainly comprises thymol, carvacrol, thymol acetate, carvacrol acetate, α -caryophyllene and the like, the content of the volatile oil is more than 99 percent, the flavonoid mainly comprises luteolin, apigenin, baicalein-7-methyl ether and the like, and the organic acid mainly comprises chlorogenic acid, caffeic acid and the like.
The elsholtzia extract has the efficacy of A and antibiosis, and a plurality of reports report that elsholtzia volatile oil has stronger broad-spectrum antibacterial action, and the antibacterial active ingredients of the elsholtzia extract comprise thymol, carvacrol, p-cymene, caryophyllene oxide, luteolin, quercetin, 4-terpineol and the like, and the elsholtzia extract has certain antibacterial and bactericidal activity on typhoid bacillus, staphylococcus aureus, enteritis bacillus and escherichia coli. B. The elsholtzia volatile oil has obvious inhibition and killing effects on the expansion of cotton aphid population, and the effect of killing cotton aphids is better than acetamiprid wettable powder and abamectin emulsifiable solution; C. the elsholtzia haichowensis contains flavonoid compounds which have electrophilic capability and can remove free radicals and prevent chain reaction, thereby inhibiting lipid from being overoxidized.
A process for preparing the extract of Chinese mosla herb (201310746669.0) includes microwave heating while extracting in solvent, and features that the Chinese mosla herb extract is not enriched and purified, resulting in unstable color and smell.
Microwave extraction is an advanced and efficient extraction technology, and the extracted product has chemical component difference with the traditional alcohol extraction.
Method for extracting and separating pseudoschizonepeta glycoside, homoplantarin and apigenin glycoside from Elsholtzia splendens-201510582357. X; 105218605B, describes a method for separating monomeric pseudoschizonepeta glycosides, homoplantaginosides and apigenin glycosides from elsholtzia.
Elsholtzia extract and its preparation process and application-201410238435 describes the preparation process of Elsholtzia extract and its composition. The elsholtzia extract is not purified.
A method for comprehensively extracting volatile oil, polysaccharide and flavone from Elsholtzia splendens (lour.) Moss-201310391507. X describes a comprehensive utilization method of Elsholtzia splendens, which well utilizes various components in Elsholtzia splendens. There are also problems with unpurification in the aforementioned patents. A Chinese medicine in the form of dripping pill for treating the diseases caused by cold injury, etc is prepared from the extract of Chinese mosla herb through liquid paraffin and talc powder 200510004992.6. Patent method for extracting and separating rosmarinic acid, apigenin and luteolin from elsholtzia haichowensis-201310042896.5 describes a method for separating monomer rosmarinic acid, apigenin and luteolin. Is not suitable for industrialized production. A method for preparing herba Moslae essential oil, CN201310344665.X, describes a supercritical extraction method of herba Moslae oil with CO2, which is a high-quality oil extraction method, and the preparation principle is essentially different from the present patent.
Disclosure of Invention
Aiming at the defects, the invention provides the elsholtzia extract for cosmetics, which has the characteristics of stable quality, industrial production, high product conversion rate, low cost, low energy consumption and the like.
The technical scheme is as follows: an elsholtzia extract for cosmetics, which contains:
thymol is more than or equal to 7.0 wt%
The content of carvacrol is more than or equal to 4.0 wt%
The total flavone content is greater than or equal to wt 3%, wherein the total content of thymol, carvacrol and total flavone is less than 100 wt%.
The cosmetic prepared from herba Moslae extract has stable color and no odor.
The invention also provides an extraction method of the elsholtzia extract for cosmetics.
A method for extracting herba Moslae extract for cosmetic comprises the following steps:
① pulverizing herba Moslae;
② extracting with ethanol;
③ concentrating the extractive solution by molecular distillation;
④ diluting with water;
⑤ centrifuging to remove impurities;
⑥ adsorbing with macroporous resin, and eluting with ethanol;
⑦ decolorizing the eluate with resin, and collecting the decolorized liquid;
⑧ deproteinizing the decolorized liquid with resin to obtain deproteinized liquid containing ammonia and nitrogen;
⑨ concentrating ammonia nitrogen liquid such as deproteinized liquid with membrane;
⑩ concentrating the concentrated solution with molecular distillation concentrator, and drying to obtain light yellow white extract.
The method can be used for industrial production, and has the advantages of high product conversion rate, low cost and low energy consumption.
The elsholtzia extract extracted by the invention has stable quality, can be industrially produced, has the characteristics of high product conversion rate, low cost, low energy consumption and the like, is used for producing cosmetics, and the produced cosmetics have stable color and no odor.
Explanation and glossary of terms
In the present invention,% means mass% unless otherwise specified.
Detailed Description
The present invention will be further explained below.
A method for extracting herba Moslae extract for cosmetic comprises the following steps:
① pulverizing herba Moslae.
② extracting with ethanol.
③ and concentrating the extracted liquid by molecular distillation.
④ diluting with water.
⑤ centrifugation removes impurities.
⑥ macroporous resin is adsorbed and then eluted by ethanol.
⑦ decolorizing the eluate with resin, and collecting the decolorized liquid.
⑧ the decolorized liquid is deproteinized with resin to collect the deproteinized liquid.
⑨ the liquid containing ammonia nitrogen such as deproteinized liquid is concentrated with membrane.
⑩ concentrating the concentrated solution with molecular distillation concentrator, and drying to obtain light yellow white extract.
Example 1
Pulverizing 200g herba Moslae raw material (dry aerial part of herba Moslae) into 10-60 mesh, extracting with 70% ethanol at 75-80 deg.C for three times, concentrating the extractive solution by molecular distillation to remove ethanol to obtain 150ml concentrated solution, diluting with hot water for 2 times, centrifuging to remove impurities, adsorbing with EVR-1# macroporous resin (EVR-1# is type and volume is 150ml), eluting with 80% ethanol, decolorizing the eluate with D285 resin (D285 resin volume is 100ml), collecting decolorized liquid, removing ammonia nitrogen such as protein with D001 resin (D001 volume is 100ml), collecting liquid of ammonia nitrogen such as protein, concentrating with molecular distillation concentrator, concentrating, and drying to obtain light yellow white extract 6.5 g. Through detection, the content of thymol in the light yellowish white extract is 6.5%, the content of carvacrol is 4.2%, and the content of total flavonoids is 3%.
Example 2
Pulverizing herba Moslae raw material 200g to 10-60 mesh, extracting with 80% ethanol at 45-50 deg.C for three times, subjecting the extractive solution to molecular distillation and concentration until no alcohol is obtained to obtain 200ml of concentrated solution, diluting with hot water for 2 times, centrifuging to remove impurities, adsorbing with EVR-1# macroporous resin (EVR-1# type, volume 150ml), eluting with 80% ethanol, decolorizing the eluate with D285 resin (D285 resin volume is 100ml), collecting decolorized liquid, removing ammonia nitrogen such as protein with D001 resin (D001 resin volume is 100ml), collecting liquid of ammonia nitrogen such as protein, concentrating with molecular distillation concentrator, concentrating, and drying to obtain light yellow white extract 6.3 g. Through detection, the content of thymol in the light yellowish white extract is 5.5%, the content of carvacrol is 3.2%, and the content of total flavonoids is 3.5%.
Example 3
Pulverizing herba Moslae raw material 200g to 10-60 mesh, extracting with 80% ethanol at 75-80 deg.C for three times, subjecting the extractive solution to molecular distillation and concentration to remove ethanol to obtain 160ml of concentrated solution, diluting with hot water for 2 times, centrifuging to remove impurities, adsorbing with EVR-1# macroporous resin (EVR-1# is type, volume is 150ml), eluting with 80% ethanol, decolorizing the eluate with D285 resin (D285 resin volume is 100ml), collecting decolorized liquid, removing ammonia nitrogen compounds such as protein with D001 resin (D001 resin volume is 100ml), collecting liquid of ammonia nitrogen compounds such as protein, concentrating with molecular distillation concentrator, concentrating, and drying to obtain light yellow white extract 7.2g, which contains thymol 7.2%, carvacrol 3.7%, and total flavone 3.2%.
Example 4
Pulverizing herba Moslae raw material 200g to 10-60 mesh, extracting with 90% ethanol at 75-80 deg.C for three times, subjecting the extractive solution to molecular distillation and concentration until no alcohol is obtained to obtain 150ml concentrated solution, diluting with hot water for 2 times, centrifuging to remove impurities, adsorbing with EVR-1# macroporous resin (EVR-1# type, volume 150ml), eluting with 80% ethanol, decolorizing the eluate with D285 resin (D285 resin volume is 100ml), collecting decolorized liquid, removing ammonia nitrogen compounds such as protein with D001 resin (D001 resin volume is 100ml), collecting liquid of ammonia nitrogen compounds such as protein, concentrating with molecular distillation concentrator, concentrating, and drying to obtain light yellow white extract 7.4g, which contains thymol 7.5%, carvacrol 4.2%, and total flavone 3%.
Comparative example 1
Pulverizing 200g herba Moslae raw material (dry aerial parts of herba Moslae) into 10-60 mesh, extracting with 70% ethanol at 75-80 deg.C for three times, concentrating the extractive solution by molecular distillation to remove ethanol to obtain 150ml concentrated solution, diluting with hot water 2 times, centrifuging to remove impurities, adsorbing with EVR-1# macroporous resin (EVR-1# type, volume 150ml), eluting with 80% ethanol, concentrating the eluate, and drying to obtain brown yellow extract 10.2g, which contains 4.8% thymol, 2.8% carvacrol and 2.1% total flavonoids.
The light yellow extract extracted in examples 1-4 of the present invention and the brown yellow extract extracted in comparative example 1 were used for the production of cosmetics, respectively, and the cosmetics produced in examples 1-4 were stable in color and free of odor.
Sample (I) | Case 1 | Case 2 | Case 3 | Case 4 | Comparative example 1 |
Concentration of sample | 1% | 1% | 1% | 1% | 1% |
Thermal stabilization | Light yellow | Light yellow | Light yellow | Light yellow | Yellow colour |
Cold stabilization | Light yellow | Light yellow | Light yellow | Light yellow | Yellow, hasPrecipitation of |
The pH8 is stable | Yellowish | Yellowish | Yellowish | Yellowish | Yellow colour |
The pH5 is stable | Light yellow | Light yellow | Light yellow | Light yellow | Yellow colour |
Illumination stabilization | Yellowish | Yellowish | Yellowish | Yellowish | Yellow colour |
Long-term stability for 30 days | Light yellow | Light yellow | Light yellow | Light yellow | Yellow colour |
Note: sample concentration samples were dissolved in water containing 30% ethylene glycol.
Thermal stability conditions: and (5) performing constant temperature culture in a 40 +/-1 incubator for 48 hours.
Cold stability conditions: in a refrigerating chamber at 3 +/-1 ℃ for 48 hours
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (3)
1. An elsholtzia extract for cosmetics, which contains:
thymol is more than or equal to 7.0 wt%
The content of carvacrol is more than or equal to 4.0 wt%
The total flavone content is greater than or equal to wt 3%, wherein the total content of thymol, carvacrol and total flavone is less than 100 wt%.
2. A method for extracting herba Moslae extract for cosmetic comprises the following steps:
① pulverizing herba Moslae;
② extracting with ethanol;
③ concentrating the extractive solution by molecular distillation;
④ diluting with water;
⑤ centrifuging to remove impurities;
⑥ adsorbing with macroporous resin, and eluting with ethanol;
⑦ decolorizing the eluate with resin, and collecting the decolorized liquid;
⑧ deproteinizing the decolorized liquid with resin to obtain deproteinized liquid containing ammonia and nitrogen;
⑨ concentrating ammonia nitrogen liquid such as deproteinized liquid with membrane;
⑩ concentrating the concentrated solution with molecular distillation concentrator, and drying to obtain light yellow white extract.
3. The method for extracting herba Moslae extract for cosmetics according to claim 2, wherein the extract is obtained by pulverizing herba Moslae to 10-60 mesh in ①, extracting 70-80% ethanol in ② at 45-50 deg.C in ③.
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CN104312729A (en) * | 2014-10-23 | 2015-01-28 | 湖南省百里香天然生物制品开发有限公司 | Extracting method of elsholtia containing 0.5% to 1.5% of thymol |
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