CN111387481A - Nicotinamide mononucleotide and herbal extract microcapsule and preparation device thereof - Google Patents
Nicotinamide mononucleotide and herbal extract microcapsule and preparation device thereof Download PDFInfo
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- CN111387481A CN111387481A CN202010243588.9A CN202010243588A CN111387481A CN 111387481 A CN111387481 A CN 111387481A CN 202010243588 A CN202010243588 A CN 202010243588A CN 111387481 A CN111387481 A CN 111387481A
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- nicotinamide mononucleotide
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Images
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
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- A23L3/3472—Compounds of undetermined constitution obtained from animals or plants
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/3463—Organic compounds; Microorganisms; Enzymes
- A23L3/3481—Organic compounds containing oxygen
- A23L3/3499—Organic compounds containing oxygen with doubly-bound oxygen
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01F27/11—Stirrers characterised by the configuration of the stirrers
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
- B01J19/10—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing sonic or ultrasonic vibrations
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
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- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a nicotinamide mononucleotide and herbal extract microcapsule with limited component proportion, which can exert the maximum immune resistance function; the preparation device comprises a container for containing nicotinamide mononucleotide, herbal active extract and extraction solvent and a return pipe, wherein the return pipe is provided with a feeding pipe, a delivery pipe and a connecting pipe; a necking component is arranged in the connecting pipe. The device also comprises an ultrasonic component which is arranged in the connecting pipe and can generate ultrasonic waves to rapidly mix the nicotinamide mononucleotide and the herbal active extract in the mixed solution. The invention aims to utilize a novel process, uniformly fuses the herbal concentrated solution and the excipient/emulsifier by utilizing a microencapsulation technology, and coats the outer layer with the traditional excipient or emulsifier, thereby improving the proportion of functional components, reducing the content of the excipient and increasing the bioavailability requirements of the nicotinamide mononucleotide and the herbal active extract.
Description
Technical Field
The invention relates to the technical field of food processing, in particular to a nicotinamide mononucleotide and herbal extract microcapsule and a preparation device thereof.
Background
In recent years, with the development of economy, the dietary composition and composition ratio of residents are greatly changed, and how to select safe and nutritional edible oil is more important, so that people with immune deficiency can reasonably take in nutrition, and the nutritional requirements of people with immune deficiency for growth are met. Since the oxidation problem of the components used in general microencapsulation is a key problem affecting the product quality in the food industry, the oxidation of fatty acids directly leads to the reduction of the quality of the formula product of people with immune deficiency, and causes serious harm to the growth and development of people with immune deficiency. The microencapsulation of the nicotinamide mononucleotide and the herbal extract can isolate air, ensure the nutritional quality and the edible safety of the formula product of people with immune deficiency, but the technical problem is that the nicotinamide mononucleotide and the herbal extract can play the maximum function by adjusting the component proportion of the nicotinamide mononucleotide and the herbal extract.
The microcapsule technology is an encapsulation technology in which solid fine particles, liquid droplets or gas are used as core materials of microcapsules, and one or more substances are compounded on the core materials to form a continuous film. By applying microencapsulation technology, edible protein and saccharide of people with immune deficiency are used as wall materials, and the health-care functional components which are easy to oxidize and deteriorate are embedded, so that the functional components can be separated from the external environment, the functional substances are prevented from being oxidized due to contact with air, and the oxidation failure of the functional substances is delayed. The microencapsulated nicotinamide mononucleotide and herbal extract not only overcome the defects of the traditional production process, but also have the advantages of instant dissolution in water, high stability, convenience in transportation, production, storage and the like, and greatly widen the application range.
Many health product industries today use nicotinamide mononucleotide and herbal active extracts for microencapsulation, and the nicotinamide mononucleotide and herbal active extracts are powders that need to be dissolved, extracted and purified to achieve effective functions. Therefore, it is necessary to release the active ingredient by dissolving nicotinamide mononucleotide and the herbal active extract through the preparation apparatus. The common microencapsulation device mostly utilizes a high-pressure and low-pressure or shearing mode to stir and mix, and pressure difference is generated by pressurizing and instantly reducing pressure through liquid, so that suspended liquid is uniformly mixed and embedded. Therefore, how to design a device capable of uniformly and sufficiently nano-microencapsulating a liquid sample becomes an important issue to be solved.
Disclosure of Invention
Aiming at the defects in the technology, the invention provides a nicotinamide mononucleotide and herbal extract microcapsule, a preparation device and a preparation method thereof.
The technical scheme adopted by the invention for solving the technical problems is as follows:
a nicotinamide mononucleotide and herbal extract microcapsule comprises the following raw materials in percentage by mass: 30-40% of nicotinamide mononucleotide and herbal active extract, 50-70% of wall material, 0.01-0.02% of antioxidant, 0.5-2.5% of emulsifier and 0.02-0.5% of stabilizer.
Preferably, the nicotinamide mononucleotide and herbal extract comprise the following oil in percentage by mass: 40-60% of antrodia camphorata polysaccharide, 5-20% of antrodia camphorata active protein, 10-20% of antrodia camphorata triterpene compound, 10-20% of fucoidan and 1-15% of pycnogenol.
Preferably, in the nicotinamide mononucleotide and the herbal extract, the mass percentage of the antrodia camphorata triterpene is as follows: the mass percent of the antrodia camphorata polysaccharide is as follows: the mass percent of the antrodia camphorata active protein = 1: 1.5-2.0: 4.9 to 5.7.
Preferably, the wall material is polypeptide polyethylene glycol, polyethylene glycol and indigestible dextrin, and the mass ratio of the wall material is 1: 1.1-1.6: 2.5 to 3.5; the antioxidant is at least one of punicosides and coenzyme Q10; the emulsifier is at least one of sucrose ester and glycerin monostearate; the stabilizer is at least one of dextran and active hexose.
The other technical scheme adopted by the invention for solving the technical problem is as follows:
a device for preparing nicotinamide mononucleotide and herbal extract microcapsules comprises: a container configured to contain a solid-liquid mixture, the solid-liquid mixture including at least a solid substance to be rapidly mixed and an extraction liquid; the wall of the container is provided with a first opening and a second opening, and the position of the first opening is lower than that of the second opening; a return pipe connected between the first opening and the second opening; an ultrasonic assembly configured for applying high frequency oscillations to the solid-liquid mixture within the return tube; the infusion pump is configured to pump the solid-liquid mixture into the return pipe through the first opening, and return the solid-liquid mixture into the container through the second opening after flowing through the return pipe;
wherein, a stirring component and a temperature detection component are arranged in the container; the return pipe is provided with a valve; the frequency of the high-frequency oscillation applied by the ultrasonic component is 10Hz to 90 kHz.
Preferably, the return pipe includes: one end of the delivery pipe is connected with the first opening; a reducing pipe having an inverted conical portion such that the diameter of the upper end thereof is greater than the diameter of the bottom end thereof, the other end of the delivery pipe being communicated with the upper end of the reducing pipe; a feeding pipe, one end of which is connected with the second opening; and the upper end of the connecting pipe is connected with the other end of the feeding pipe, and the lower end of the connecting pipe is inserted into the necking pipe and is close to the bottom end of the inverted cone-shaped part.
Preferably, the ultrasonic assembly is arranged in the connecting pipe at a position close to the necking pipe; the ultrasonic component is in a strip shape, and the length of the ultrasonic component is less than half of the length of the connecting pipe; the diameter of the bottom end of the necking pipe is 1/5-2/3 of the diameter of the upper end; a distance of 0.5-6 cm is formed between the bottom end of the ultrasonic assembly and the bottom end of the necking pipe; the feeding pipe is provided with a detection assembly for detecting the microencapsulation state.
Preferably, the stirring assembly consists of at least one stirrer; the agitator includes a rotating shaft; the first frame body and the second frame body are fixed on the shaft body and basically combined into a rectangular frame; the first stirring plate and the second stirring plate are fixed on the shaft body and positioned in the rectangular frame; the third stirring plate is positioned in the rectangular frame and fixed on the first frame body; and the fourth stirring plate is positioned in the rectangular frame and is fixed on the second frame body.
Preferably, the number of the first stirring plate, the second stirring plate, the third stirring plate and the fourth stirring plate is multiple; the first stirring plate and the third stirring plate are positioned on one side of the shaft body and are arranged at intervals; the second stirring plate and the fourth stirring plate are located on the other side of the shaft body and are arranged at intervals.
The invention adopts another technical scheme for solving the technical problems that:
a preparation method of nicotinamide mononucleotide and herbal extract microcapsules comprises the following steps:
(1) weighing a certain proportion of nicotinamide mononucleotide and herbal active extract, mixing with antioxidant and emulsifier, heating to 60-75 ℃ for dissolving, and uniformly stirring to obtain a core material solution;
(2) weighing wall materials and a stabilizer in a certain proportion, mixing, adding the mixture into water, heating to 35-55 ℃, and stirring until the mixture is fully dissolved to prepare a wall material solution with the solid content of 11-20%;
(3) mixing the core material solution and the wall material solution, uniformly stirring at 60-75 ℃ to form a stable emulsion, and homogenizing for 2-4 times by using a high-frequency oscillation homogenizer to prepare an emulsion;
(4) and (3) drying the prepared emulsion in a nanometer microcapsule dryer at the air inlet temperature of 170-190 ℃ and the air outlet temperature of 90-100 ℃ to obtain the nicotinamide mononucleotide and herbal extract microcapsule with immunoregulation and antivirus functions.
Compared with the prior art, the invention has the beneficial effects that:
(1) the nicotinamide mononucleotide and herbal extract microcapsule core material with immunoregulation and antivirus functions is composed of antrodia camphorata polysaccharide, antrodia camphorata active protein, antrodia camphorata triterpene compounds, fucoidan and pycnogenol, which are five high-quality raw material antrodia camphorata active extracts. Respectively has the functions of promoting the proliferation of lymphocytes, activating B cells, increasing the antibody content in serum, improving the phagocytosis of macrophages and natural killer cells, resisting the inhibition of an immunosuppressant, promoting ConA-induced splenic lymphocyte proliferation reaction of mice and the transformation of alloantigen-stimulated lymphocytes;
(2) the emulsifier, the antioxidant and the stabilizer are added into the nicotinamide mononucleotide and herbal extract microcapsule with immunoregulation and antivirus functions, so that the product has good taste and flavor, the stability of a finished product is further improved, and the shelf life is prolonged;
(3) the invention relates to a preparation device for microcapsules of nicotinamide mononucleotide and herbal extracts, which can enable mixed liquid to generate actions of stirring, impacting, shaking and the like in the flowing process of the mixed liquid in the preparation device through a necking component, an ultrasonic component and a stirring component at the bottom of a container, continuously disperse functional component particles, release small molecular substances due to breakage and carry out microencapsulation. Therefore, compared with the traditional microencapsulation device, the liquid sample can be uniformly stirred and mixed, and microencapsulation can be simultaneously carried out.
In addition, the mixed liquid continuously and circularly flows between the return pipe and the container, so that the nicotinamide mononucleotide and the herbal active extract in the mixed liquid can be repeatedly vibrated by the ultrasonic component, and the nicotinamide mononucleotide and the herbal active extract can be more fully coated. Because the second diameter of the second end of the necking component is substantially equal to the diameter of the ultrasonic component and is close to the ultrasonic component, when the mixed liquid flows through the necking component, the mixed liquid can be tightly attached to the ultrasonic component and is vibrated by the ultrasonic component, and the phenomenon that the liquid sample is coated unevenly is effectively avoided.
(4) The nicotinamide mononucleotide and herbal extract microcapsule with immunoregulation and antivirus functions selects a nanometer microcapsule dryer method, is simple in production process, convenient to operate, capable of being operated continuously, completely suitable for requirements of industrial large-scale production, easy to popularize and wide in industrial prospect.
Drawings
FIG. 1 is a schematic structural diagram of an apparatus for preparing microcapsules of nicotinamide mononucleotide and herbal extracts of the invention;
FIG. 2 is an enlarged view of a portion 201 of FIG. 1;
fig. 3-4 are schematic views of the stirrer in different views.
In the figure, 10A, nicotinamide mononucleotide and herbal active extract, 10B, microencapsulated coating solvent, 10, mixed liquor, 110, a container, 112A, a feeding pipe, 112B, a connecting pipe, 112C, a delivery pipe, 114, an infusion pump, 116, an ultrasonic assembly, 118, a stirring assembly, 120, a necking assembly, 120-1, a first end, 120-2, a second end, 122, a detection assembly, 124, a temperature regulator, 201, a local area, L1, a connecting pipe length, L2, an ultrasonic assembly length, D, a distance, D, an ultrasonic assembly diameter, D1, a first diameter, D2, a second diameter, 90, a shaft body, 911, a first frame body, 912, a second frame body, 931, a first stirring plate, 932, a second stirring plate, 921, a third stirring plate, 922 and a fourth stirring plate are included.
Detailed Description
The present invention is further described in detail below with reference to the attached drawings so that those skilled in the art can implement the invention by referring to the description text.
The invention provides a nicotinamide mononucleotide and herbal extract microcapsule with immunoregulation and antivirus functions, which comprises the following raw materials in percentage by mass: 30-40% of nicotinamide mononucleotide and herbal active extract, 50-70% of wall material, 0.01-0.02% of antioxidant, 0.5-2.5% of emulsifier and 0.02-0.5% of stabilizer.
Wherein, the nicotinamide mononucleotide and the herbal extract comprise the following grease in percentage by mass: 40-60% of antrodia camphorata polysaccharide, 5-20% of antrodia camphorata active protein, 10-20% of antrodia camphorata triterpene compound, 10-20% of fucoidan and 1-15% of pycnogenol.
Further, in nicotinamide mononucleotide and herbal extracts, the mass percentage of the antrodia camphorata triterpene compound is as follows: the mass percent of the antrodia camphorata polysaccharide is as follows: the mass percent of the antrodia camphorata active protein = 1: 1.5-2.0: 4.9 to 5.7.
Further, the wall material is polypeptide polyethylene glycol, indigestible dextrin and active hexose, and the mass ratio of the polypeptide polyethylene glycol, the indigestible dextrin and the active hexose is 1: 1.1-1.6: 2.5 to 3.5.
Further, the antioxidant is at least one of pomegranate polyphenols and coenzyme Q10; the emulsifier is at least one of sucrose ester and glycerin monostearate; the stabilizer is at least one of dextran and xanthan gum.
Referring to fig. 1, the present invention further provides an apparatus for preparing microcapsules of nicotinamide mononucleotide and herbal extracts, comprising a container 110 and a return pipe, wherein a stirring component 118 is disposed at the bottom of the container 110, and the return pipe has a feeding pipe 112A and a discharge pipe 112C, and a connecting pipe 112B connected to the feeding pipe 112A and the discharge pipe 112C.
In a specific application scenario, the return pipe may be shaped like ㄈ, and the feeding pipe 112A and the discharging pipe 112C of the return pipe are connected to the bottom and the top of the sidewall of the container 110, respectively. Further, an infusion pump 114 is disposed in the feeding tube 112A, and an ultrasonic element 116 and a necking-down element 120 are disposed in the connecting tube 112B, wherein one end of the ultrasonic element 116 is located in the connecting tube 112B, and the ultrasonic element 116 is adjacent to the end of the necking-down element 120 with a smaller diameter.
Specifically, the nicotinamide mononucleotide and the herbal active extract 10A and the microencapsulated coating solvent 10B can be directly added into the internal space of the container 110 from the upper opening of the container 110 to form a mixed solution 10 containing the nicotinamide mononucleotide and the herbal active extract 10A and the microencapsulated coating solvent 10B. In an application scenario, the nicotinamide mononucleotide and the herbal active extract 10A and the microencapsulated coating solvent 10B can be added to the inner space of the container 110 through a feeding pipe (not shown), so as to form a mixed solution 10 containing nicotinamide mononucleotide and the herbal active extract 10A and the microencapsulated coating solvent 10B. In another application scenario, a mixture 10 containing nicotinamide mononucleotide and herbal extract 10A and microencapsulated coating solvent 10B can be formed and then delivered to the interior space of container 110 through the feed tube. Specifically, the microencapsulated coating solvent 10B is water, an emulsifier, a polymer coating agent, and a colloid.
Then, the stirring component 118 located at the bottom of the container 110 is used to break up the nicotinamide mononucleotide and the herbal active extract 10A in the mixed solution 10, and the nicotinamide mononucleotide and the herbal active extract 10A and the microencapsulated coating solvent 10B are uniformly mixed to promote the extraction function. In one application scenario, the stirring assembly 118 may be composed of a single stirrer or may be composed of a plurality of stirrers. Further, the stirrers may be disposed entirely at the bottom of the vessel 110, and the stirrers may be arranged in a row along a direction perpendicular to the bottom of the vessel 110 to form an elongated stirring assembly 118.
As shown in fig. 3 and 4, in order to improve the stirring capacity of the stirring assembly 118, the stirrer includes a shaft body 90 disposed in the container 110 and capable of being rotated by a rotary driver (e.g., a motor); a first frame body 911 and a second frame body 912 which are fixed on the shaft body 90 and basically combined into a rectangular frame; a first agitating plate 931 and a second agitating plate 932 fixed to the shaft 90 and positioned in the rectangular frame; a third agitating plate 921 located inside the rectangular frame and fixed to the first frame 911; and a fourth agitating plate 922 located inside the rectangular frame and fixed to the second frame body 912.
Specifically, the first stirring plate 931, the second stirring plate 932, the third stirring plate 921 and the fourth stirring plate 922 are all defined to be disposed toward the shaft body 90; the first agitating plate 931, the second agitating plate 932, the third agitating plate 921, and the fourth agitating plate 922 are arranged on both sides of the shaft body 90 in a center-symmetric manner.
Further, the first agitating plate 931 and the fourth agitating plate 922 are disposed at an angle between 20 ° and 70 ° with respect to the shaft 90.
In a specific application environment, the number of the first stirring plate 931, the second stirring plate 932, the third stirring plate 921 and the fourth stirring plate 922 is multiple; the first stirring plate 931 and the third stirring plate 921 are located at one side of the shaft 90, and are arranged at intervals; second stirring plate 932 and fourth stirring plate 922 are located at the other side of shaft 90, and both are set up for the looks interval.
Then, the liquid mixture 10 is delivered from the bottom of the container 110 to the connection pipe 112B through the feeding pipe 112A of the return pipe by the liquid delivery pump 114, and the volume of the liquid mixture 10 flowing through the connection pipe 112B is reduced by the necking component 120 of the connection pipe 112B. As an embodiment of the present invention, the reducing assembly 120 and the return pipe may be integrally formed, or the reducing assembly 120 and the return pipe may be separately formed and then integrated together.
Thereafter, ultrasonic waves are generated by the ultrasonic wave module 116 to microencapsulate the nicotinamide mononucleotide and the herbal active extract 10A in the mixed solution 10 whose volume is reduced by the necking module 120.
Specifically, the ultrasonic assembly 116 generates ultrasonic waves having a frequency between about 1kHz and about 90 kHz. Since the smaller the frequency, the stronger the microencapsulation force is generated, and when the frequency is more than 20kHz, the mechanical force is too strong, resulting in a reduction in the lifetime of the entire device, thereby increasing the production cost. Conversely, when the frequency is less than 1kHz, the microencapsulation effect is poor.
In the present embodiment, the connecting tube 112B has a length L1, the ultrasonic module 116 has a long strip structure, and the length L2 of the ultrasonic module 116 is 1/2 which is substantially less than the length L1.
The ultrasonic component 116 uses vibration magnetism to convert electrical energy into mechanical motion, which generates vibration. The ultrasonic wave assembly 116 not only can make the cells of the nicotinamide mononucleotide and the herbal active extract 10A in the mixed solution 10 collide with each other, but also can make the molecules of the microencapsulated coating solvent 10B collide with the cells of the nicotinamide mononucleotide and the herbal active extract 10A, thereby achieving better microencapsulation effect.
Referring to fig. 2, an enlarged view of a portion 201 of fig. 1 is shown. The throat assembly 120 has a first end 120-1 and an opposite second end 120-2, and the first end 120-1 and the second end 120-2 have a first diameter d1 and a second diameter d2, respectively, wherein the second diameter d2 is less than the first diameter d 1. In the present embodiment, the second diameter d2 is substantially between 2/3 and 1/5 of the first diameter d1, or substantially between 1/2 and 1/4 of the first diameter d 1. In an application scenario, the necking module 120 may be funnel-shaped. Further, the diameter D of the ultrasonic assembly 116 is substantially equal to the second diameter D2. Wherein the second end 120-2 of the throat assembly 120 is positioned between the first end 120-1 and the ultrasonic assembly 116 and the second end 120-2 is spaced a distance d from the ultrasonic assembly 116. Specifically, the distance d is between about 0.5 cm and about 6cm, or between about 1 cm and about 5 cm.
Referring to fig. 1 again, after the nicotinamide mononucleotide and the herbal active extract 10A of the mixed solution 10 are acted by the ultrasonic assembly 116, the mixed solution 10 is conveyed back to the inner space of the container 110 through the delivery pipe 112C of the return pipe, and the above-mentioned process is repeated again, so that the mixed solution 10 circulates in the preparation apparatus, the ultrasonic assembly 116 repeatedly performs microencapsulation on the nicotinamide mononucleotide and the herbal active extract 10A in the mixed solution 10, and in the process of circulating the mixed solution 10, the active ingredients in the nicotinamide mononucleotide and the herbal active extract 10A are extracted into the microencapsulated coating solvent 10B.
In an application scenario, the delivery tube 112C can be connected to the detecting element 122, and the detecting element 122 can be used to detect the microencapsulation of the nicotinamide mononucleotide and the herbal active extract 10A in the mixed solution 10 in the delivery tube 112C.
Further, the inlet pipe 112A and the outlet pipe 112C of the return pipe are provided with valves respectively for opening or closing a passage between the inlet pipe 112A and the reservoir 110 and a passage between the outlet pipe 112C and the reservoir 110. When the microencapsulation is not needed, the valve is closed to leave the mixed solution 10 in the inner space of the container 110, so that the nicotinamide mononucleotide and the active ingredient in the herbal active extract 10A can be sufficiently extracted to the microencapsulated coating solvent 10B.
In this embodiment, the container 110 can be connected to a temperature controller 124 to control the temperature of the mixed solution 10, and can be controlled according to the temperature required for actual microencapsulation or extraction.
In summary, in the apparatus for preparing nicotinamide mononucleotide and herbal extract microcapsule of the present embodiment, the necking module, the ultrasonic module and the stirring module at the bottom of the container can generate actions such as stirring, impacting and shaking during the flowing process of the mixed solution in the preparation apparatus, thereby continuously dispersing the functional component particles, releasing the small molecular substances by breaking and simultaneously performing microencapsulation. Therefore, compared with the traditional microencapsulation device, the liquid sample can be uniformly stirred and mixed, and microencapsulation can be simultaneously carried out.
In addition, the mixed liquid continuously and circularly flows between the return pipe and the container, so that the nicotinamide mononucleotide and the herbal active extract in the mixed liquid can be repeatedly vibrated by the ultrasonic component, and the nicotinamide mononucleotide and the herbal active extract can be more fully coated. Because the second diameter of the second end of the necking component is substantially equal to the diameter of the ultrasonic component and is close to the ultrasonic component, when the mixed liquid flows through the necking component, the mixed liquid can be tightly attached to the ultrasonic component and is vibrated by the ultrasonic component, and the phenomenon that the liquid sample is coated unevenly is effectively avoided.
The invention also provides a preparation method of the nicotinamide mononucleotide and herbal extract microcapsule, which comprises the following steps:
(1) weighing a certain proportion of grease components, mixing with an antioxidant and an emulsifier, heating to 60-75 ℃ for dissolution, and uniformly stirring to prepare a core material solution;
(2) weighing wall materials and a stabilizer in a certain proportion, mixing, adding the mixture into water, heating to 35-55 ℃, and stirring until the mixture is fully dissolved to prepare a wall material solution with the solid content of 11-20%;
(3) mixing the core material solution and the wall material solution, uniformly stirring at the temperature of 60-75 ℃ to form a stable emulsion, and homogenizing for 2-4 times by using a high-frequency oscillation homogenizer;
(4) and (3) drying the prepared emulsion in a nanometer microcapsule dryer at the air inlet temperature of 170-190 ℃ and the air outlet temperature of 90-100 ℃ to obtain the nicotinamide mononucleotide and herbal extract microcapsule with immunoregulation and antivirus functions.
The invention aims to utilize a novel process, uniformly fuses the herbal concentrated solution and the excipient/emulsifier by utilizing a microencapsulation technology, and has the effects of improving the proportion of functional components, reducing the content of the excipient and increasing the bioavailability requirement of the plant extract by only coating the outer layer of the herbal concentrated solution and the excipient/emulsifier which are different from the traditional excipient or emulsifier. In addition, the concentrated solution is added with emulsifier to stabilize water-soluble and oil-soluble components in the effective components, so as to develop nicotinamide mononucleotide and herbal extract microcapsule with immunoregulation and antivirus functions with high stability and uniform functional targets.
According to the dietary nutrition requirements of people with immunodeficiency, the prepared microcapsules are reasonable in composition after the antrodia camphorata polysaccharide is taken as a basis and is scientifically matched with the active protein and the triterpenoid, the health of people with immunodeficiency is facilitated, the immunity of the organism is enhanced, the preparation process is simple, the industrialized production is facilitated, and the prospect is wide.
While embodiments of the invention have been described above, it is not limited to the applications set forth in the description and the embodiments, which are fully applicable in various fields of endeavor to which the invention pertains, and further modifications may readily be made by those skilled in the art, it being understood that the invention is not limited to the details shown and described herein without departing from the general concept defined by the appended claims and their equivalents.
Claims (10)
1. The nicotinamide mononucleotide and herbal extract microcapsule is characterized by comprising the following raw materials in percentage by mass: 30-40% of nicotinamide mononucleotide and herbal extract, 50-70% of wall material, 0.01-0.02% of antioxidant, 0.5-2.5% of emulsifier and 0.02-0.5% of stabilizer.
2. The nicotinamide mononucleotide and herbal extract microcapsule of claim 1, wherein the nicotinamide mononucleotide and herbal extract comprises the following oil in percentage by mass: 40-60% of antrodia camphorata polysaccharide, 5-20% of antrodia camphorata active protein, 10-20% of antrodia camphorata triterpene compound, 10-20% of fucoidan and 1-15% of pycnogenol.
3. The nicotinamide mononucleotide and herbal extract microcapsule of claim 2, wherein in the nicotinamide mononucleotide and herbal extract, the mass percent of antrodia camphorata triterpene is: the mass percent of the antrodia camphorata polysaccharide is as follows: the mass percent of the antrodia camphorata active protein = 1: 1.5-2.0: 4.9 to 5.7.
4. The nicotinamide mononucleotide and herbal extract microcapsule of claim 1, wherein the wall material is polypeptide polyethylene glycol, polyethylene glycol and indigestible dextrin, and the mass ratio of the wall material to the wall material is 1: 1.1-1.6: 2.5 to 3.5; the antioxidant is at least one of pomegranate polyphenol and coenzyme Q10; the emulsifier is at least one of sucrose ester and glycerin monostearate; the stabilizer is at least one of dextran and active hexose.
5. The apparatus of claim 1, comprising:
a container configured to contain a solid-liquid mixture including at least solid matter to be rapidly homogenized and an extraction liquid; a first opening and a second opening are formed in the wall of the container, and the position of the first opening is lower than that of the second opening;
a return pipe connected between the first opening and the second opening;
an ultrasonic assembly configured for applying high frequency oscillations to the solid-liquid mixture within the flowtube; and
the infusion pump is configured to be used for pumping the solid-liquid mixture into the return pipe through the first opening, and sending the solid-liquid mixture back into the container through the second opening after flowing through the return pipe;
wherein, a stirring component and a temperature detection component are arranged in the container; a valve is arranged on the return pipe; the frequency of the ultrasonic wave component applying high-frequency oscillation is 10 Hz-90 kHz.
6. The manufacturing apparatus as set forth in claim 5, wherein said return pipe includes:
one end of the delivery pipe is connected with the first opening;
a reducing pipe having an inverted conical portion such that the diameter of the upper end thereof is greater than the diameter of the bottom end thereof, the other end of the delivery pipe being communicated with the upper end of the reducing pipe;
a feeding pipe, one end of which is connected with the second opening; and
and the upper end of the connecting pipe is connected with the other end of the feeding pipe, and the lower end of the connecting pipe is inserted into the necking pipe and is close to the bottom end of the inverted cone-shaped part.
7. The manufacturing apparatus of claim 6, wherein the ultrasonic assembly is disposed within the connecting tube at a location proximate to the throat tube; the ultrasonic assembly is in a strip shape, and the length of the ultrasonic assembly is less than half of the length of the connecting pipe; the diameter of the bottom end of the necking pipe is 1/5-2/3 of the diameter of the upper end; the distance between the bottom end of the ultrasonic assembly and the bottom end of the necking pipe is 0.5-6 cm; the feeding pipe is provided with a detection assembly for detecting the microencapsulation state.
8. The manufacturing apparatus of claim 5, wherein the agitation assembly is comprised of at least one agitator; the stirrer comprises
A rotating shaft body;
the first frame body and the second frame body are fixed on the shaft body and basically combined into a rectangular frame;
the first stirring plate and the second stirring plate are fixed on the shaft body and are positioned in the rectangular frame;
the third stirring plate is positioned in the rectangular frame and fixed on the first frame body; and
and the fourth stirring plate is positioned in the rectangular frame and is fixed on the second frame body.
9. The manufacturing apparatus according to claim 8, wherein the number of the first agitating plate, the second agitating plate, the third agitating plate, and the fourth agitating plate is plural;
the first stirring plate and the third stirring plate are positioned on one side of the shaft body and are arranged at intervals; the second stirring plate and the fourth stirring plate are positioned on the other side of the shaft body and are arranged at intervals.
10. The manufacturing apparatus according to claim 5, wherein the manufacturing method comprises the steps of:
(1) weighing a certain proportion of nicotinamide mononucleotide and herbal active extract, mixing with antioxidant and emulsifier, heating to 60-75 ℃ for dissolving, and uniformly stirring to obtain a core material solution;
(2) weighing wall materials and a stabilizer in a certain proportion, mixing, adding the mixture into water, heating to 35-55 ℃, and stirring until the mixture is fully dissolved to prepare a wall material solution with the solid content of 11-20%;
(3) mixing the core material solution and the wall material solution, uniformly stirring at 60-75 ℃ to form a stable emulsion, and homogenizing for 2-4 times by using a high-frequency oscillation homogenizer to prepare an emulsion;
(4) and (3) drying the prepared emulsion in a nanometer microcapsule dryer at the air inlet temperature of 170-190 ℃ and the air outlet temperature of 90-100 ℃ to obtain the nicotinamide mononucleotide and herbal extract microcapsule with immunoregulation and antivirus functions.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112089705A (en) * | 2020-09-28 | 2020-12-18 | 深圳雾件科技有限公司 | Nicotinamide mononucleotide microcapsule and preparation method thereof |
| CN112891241A (en) * | 2021-02-06 | 2021-06-04 | 武汉百思凯瑞生物科技有限公司 | Targeted mitochondrial skin anti-aging nano composition and preparation method and application thereof |
| CN113262736A (en) * | 2021-04-28 | 2021-08-17 | 林丽坪 | Novel semiconductor material preparation machine for phenolic wastewater treatment |
| CN115486539A (en) * | 2022-09-14 | 2022-12-20 | 厦门遇见今生生物科技有限公司 | Herbal extract biomimetic membrane with anti-aging and telomere lengthening effects and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWM476604U (en) * | 2013-12-11 | 2014-04-21 | Sheng-Pin Chiu | Antrodia cinnamomea extract particle structure capable of enhancing liver function and reducing liver index |
| TWM554915U (en) * | 2017-09-29 | 2018-02-01 | 百德生物科技有限公司 | A device for disrupting and extracting antrodia cinnamomea |
| CN110179118A (en) * | 2019-07-01 | 2019-08-30 | 佳格食品(厦门)有限公司 | A kind of sunflower seeds nutrient blend oil microcapsules and preparation method thereof suitable for infant |
-
2020
- 2020-03-31 CN CN202010243588.9A patent/CN111387481A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWM476604U (en) * | 2013-12-11 | 2014-04-21 | Sheng-Pin Chiu | Antrodia cinnamomea extract particle structure capable of enhancing liver function and reducing liver index |
| TWM554915U (en) * | 2017-09-29 | 2018-02-01 | 百德生物科技有限公司 | A device for disrupting and extracting antrodia cinnamomea |
| CN110179118A (en) * | 2019-07-01 | 2019-08-30 | 佳格食品(厦门)有限公司 | A kind of sunflower seeds nutrient blend oil microcapsules and preparation method thereof suitable for infant |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112089705A (en) * | 2020-09-28 | 2020-12-18 | 深圳雾件科技有限公司 | Nicotinamide mononucleotide microcapsule and preparation method thereof |
| CN112891241A (en) * | 2021-02-06 | 2021-06-04 | 武汉百思凯瑞生物科技有限公司 | Targeted mitochondrial skin anti-aging nano composition and preparation method and application thereof |
| CN112891241B (en) * | 2021-02-06 | 2022-06-10 | 武汉百思凯瑞生物科技有限公司 | Targeted mitochondrial skin anti-aging nano composition and preparation method and application thereof |
| CN113262736A (en) * | 2021-04-28 | 2021-08-17 | 林丽坪 | Novel semiconductor material preparation machine for phenolic wastewater treatment |
| CN115486539A (en) * | 2022-09-14 | 2022-12-20 | 厦门遇见今生生物科技有限公司 | Herbal extract biomimetic membrane with anti-aging and telomere lengthening effects and preparation method thereof |
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