CN109953336A - A kind of high instant microcapsule powder of carrying capacity polymethoxyflavone and preparation method thereof - Google Patents
A kind of high instant microcapsule powder of carrying capacity polymethoxyflavone and preparation method thereof Download PDFInfo
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- CN109953336A CN109953336A CN201910209449.1A CN201910209449A CN109953336A CN 109953336 A CN109953336 A CN 109953336A CN 201910209449 A CN201910209449 A CN 201910209449A CN 109953336 A CN109953336 A CN 109953336A
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- polymethoxyflavone
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- 239000000843 powder Substances 0.000 title claims abstract description 84
- 229930182496 polymethoxyflavone Natural products 0.000 title claims abstract description 58
- 239000003094 microcapsule Substances 0.000 title claims abstract description 49
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 53
- 239000000341 volatile oil Substances 0.000 claims abstract description 19
- 239000004519 grease Substances 0.000 claims abstract description 11
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 9
- 239000006210 lotion Substances 0.000 claims description 20
- 239000003921 oil Substances 0.000 claims description 20
- 235000019198 oils Nutrition 0.000 claims description 20
- 238000003756 stirring Methods 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 16
- MRIAQLRQZPPODS-UHFFFAOYSA-N nobiletin Chemical compound C1=C(OC)C(OC)=CC=C1C1=CC(=O)C2=C(OC)C(OC)=C(OC)C(OC)=C2O1 MRIAQLRQZPPODS-UHFFFAOYSA-N 0.000 claims description 16
- OBIOZWXPDBWYHB-UHFFFAOYSA-N Nobiletin Natural products C1=CC(OC)=CC=C1C1=C(OC)C(=O)C2=C(OC)C(OC)=C(OC)C(OC)=C2O1 OBIOZWXPDBWYHB-UHFFFAOYSA-N 0.000 claims description 15
- 108010046377 Whey Proteins Proteins 0.000 claims description 13
- 241000196324 Embryophyta Species 0.000 claims description 12
- 235000021119 whey protein Nutrition 0.000 claims description 12
- 239000012141 concentrate Substances 0.000 claims description 11
- 239000003549 soybean oil Substances 0.000 claims description 11
- 235000012424 soybean oil Nutrition 0.000 claims description 11
- 238000010438 heat treatment Methods 0.000 claims description 6
- 244000223760 Cinnamomum zeylanicum Species 0.000 claims description 5
- 108010073771 Soybean Proteins Proteins 0.000 claims description 5
- 235000017803 cinnamon Nutrition 0.000 claims description 5
- 238000012545 processing Methods 0.000 claims description 5
- 235000019710 soybean protein Nutrition 0.000 claims description 5
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 5
- -1 Flavone compound Chemical class 0.000 claims description 4
- 235000018102 proteins Nutrition 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 235000005979 Citrus limon Nutrition 0.000 claims description 3
- 244000131522 Citrus pyriformis Species 0.000 claims description 3
- 229930003944 flavone Natural products 0.000 claims description 3
- 235000011949 flavones Nutrition 0.000 claims description 3
- 150000002576 ketones Chemical class 0.000 claims description 3
- 238000000926 separation method Methods 0.000 claims description 3
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 claims description 2
- 244000290333 Vanilla fragrans Species 0.000 claims description 2
- 235000009499 Vanilla fragrans Nutrition 0.000 claims description 2
- 235000012036 Vanilla tahitensis Nutrition 0.000 claims description 2
- 102000007544 Whey Proteins Human genes 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 238000004090 dissolution Methods 0.000 claims description 2
- 238000000265 homogenisation Methods 0.000 claims description 2
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 2
- 239000000944 linseed oil Substances 0.000 claims description 2
- 235000021388 linseed oil Nutrition 0.000 claims description 2
- 235000008390 olive oil Nutrition 0.000 claims description 2
- 239000004006 olive oil Substances 0.000 claims description 2
- 238000001694 spray drying Methods 0.000 claims description 2
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000006071 cream Substances 0.000 claims 1
- 239000000047 product Substances 0.000 abstract description 20
- 150000001875 compounds Chemical class 0.000 abstract description 12
- 235000013305 food Nutrition 0.000 abstract description 11
- 239000000463 material Substances 0.000 abstract description 10
- 239000006185 dispersion Substances 0.000 abstract description 7
- 239000011162 core material Substances 0.000 abstract description 6
- 230000036541 health Effects 0.000 abstract description 4
- 239000002994 raw material Substances 0.000 abstract description 3
- 239000002537 cosmetic Substances 0.000 abstract description 2
- 239000003814 drug Substances 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 abstract description 2
- 239000003960 organic solvent Substances 0.000 abstract description 2
- 238000003860 storage Methods 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 15
- 102100029516 Basic salivary proline-rich protein 1 Human genes 0.000 description 12
- 239000012153 distilled water Substances 0.000 description 8
- 239000007908 nanoemulsion Substances 0.000 description 8
- 239000000155 melt Substances 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 238000002425 crystallisation Methods 0.000 description 4
- 230000008025 crystallization Effects 0.000 description 4
- 238000013112 stability test Methods 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 241000207199 Citrus Species 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 235000020971 citrus fruits Nutrition 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical class CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
- 235000005976 Citrus sinensis Nutrition 0.000 description 1
- 240000002319 Citrus sinensis Species 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 239000006057 Non-nutritive feed additive Substances 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 239000005862 Whey Substances 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 230000000879 anti-atherosclerotic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 235000013569 fruit product Nutrition 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 239000000383 hazardous chemical Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- LKMNXYDUQXAUCZ-UHFFFAOYSA-N sinensetin Chemical class C1=C(OC)C(OC)=CC=C1C1=CC(=O)C2=C(OC)C(OC)=C(OC)C=C2O1 LKMNXYDUQXAUCZ-UHFFFAOYSA-N 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- ULSUXBXHSYSGDT-UHFFFAOYSA-N tangeretin Chemical class C1=CC(OC)=CC=C1C1=CC(=O)C2=C(OC)C(OC)=C(OC)C(OC)=C2O1 ULSUXBXHSYSGDT-UHFFFAOYSA-N 0.000 description 1
- 235000021404 traditional food Nutrition 0.000 description 1
- 230000010148 water-pollination Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/185—Vegetable proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/19—Dairy proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5052—Proteins, e.g. albumin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
Abstract
The invention discloses a kind of instant microcapsule powders and preparation method thereof of high carrying capacity polymethoxyflavone class compound, belong to field of food.The present invention is with functional grease, polymethoxyflavone class compound, and plants essential oil is core material, reacts and is prepared with protide emulsifier wall material.Microscapsule powder prepared by the present invention has been obviously improved the carrying capacity and stability of polymethoxyflavone class compound；The solution rate of microscapsule powder obtained is very fast, water dispersion ability with higher and meltage.Moreover, the water dispersible and Manual Suture of the instant microcapsule powder of polymethoxyflavone class compound produced by the present invention also significantly improve.In addition, raw material of the present invention is food grade materials, product obtained is free of organic solvent, and preparation condition is mild, and use is safer, and stable product quality, Storage period is longer, can be widely used for food, health care product, drug, cosmetics.
Description
Technical field
The invention belongs to field of food, and in particular to a kind of instant microcapsule powder of high carrying capacity polymethoxyflavone and its preparation
Method.
Background technique
Polymethoxyflavone (polymethoxyflavones, PMFs) is mentioned from citrus plant (especially sweet orange)
A kind of natural flavonoid compound containing C6-C3-C6 skeleton and multiple methoxyl groups taken, including orange peel element (5,6,7,
8,4 '-pentamethoxyl flavones), senensetin's (5,6,7,3 ', 4 '-pentamethoxyl flavones), Nobiletin (5,6,7,8,3 ', 4 '-
Hexa methoxy flavones) etc..PMFs has extensive bioactivity, such as anti-inflammatory, antiatherosclerosis, anti-gastric cancer, adjusts rouge
Matter metabolism etc..2009~2010 U.S. Nian Jianjin consume the amount of citrus products up to 1,000 ten thousand tons, wherein 66% is to utilize citrus fruit
Meat processed fruit product, and remaining a large amount of orange peel byproduct is not fully utilized, leads to the serious wasting of resources.Therefore,
It separates and the PMFs contained in orange peel is made full use of not only to go out certain economic value for social creativity, and benefit
Human health.
Currently, the separation identification technology of PMFs is increasingly mature in orange peel, but PMFs low aqueous solubility, high-melting-point, easily crystallization
Property, cause it to be dfficult to apply in food, and be difficult to be absorbed by small intestine epithelium in vivo, limits the hair of its bioactivity
It waves.Dissolubility of this kind of fat-soluble nutrients substance of PMFs in digestive environments how is improved, becomes and improves its bioavailability
Key.It is existing research shows that lotion can be used for loading PMFs, improve its hydrophily.But the content of PMFs can be only sustained at
Relatively low concentration range, high-content PMFs are difficult to be stabilized in emulsion system, and easily crystallization is precipitated.There is research by mentioning
High oil phase concentration promotes the load capacity of PMFs, but oil phase content is up to 50%.Therefore how to realize PMFs high carrying capacity, and mention
Its stability and bioavailability are risen, is the urgent problem to be solved that exploitation is rich in PMFs food product.Currently on the market still
There is not such issues that Related product is able to solve, and meets the needs of market.
Microscapsule powder is process by food-grade wall material and core material, core material specific gravity can control 40%~80% it
Between.Traditional food micro capsule mostly uses natural polymer as wall material, such as polysaccharide, protein.By certain
Moditied processing can regulate and control the structure and characteristic of microcapsules.The present invention joined essence as wall material and in oily phase using albumen
With plants essential oil component phase can occur for oil using albumen wall material rich in there is multiple active function groups (hydroxyl, carboxyl, amino etc.)
Interaction, to be modified to obtain more preferably product to albumen wall material interface.
Based on the above reasons, special to propose the application.
Summary of the invention
In view of the problems of the existing technology, the purpose of the present invention is loading Polymethoxylated Huang for existing emulsion system
Low stability, the defect of low content in terms of ketone provide a kind of high carrying capacity, green natural, have fast dissolving properties and Gao Sheng
Object utilizability, and simple microscapsule powder of preparation process and preparation method thereof.
In order to realize above-mentioned first purpose of the invention, The technical solution adopted by the invention is as follows:
A kind of high instant microcapsule powder of carrying capacity polymethoxyflavone, by each at being grouped as of following mass percentage content:
Preferably, above-mentioned technical proposal, the high instant microcapsule powder of carrying capacity polymethoxyflavone, by following quality percentage
It is more each at being grouped as than content:
It is highly preferred that above-mentioned technical proposal, the functional grease can be soybean oil, medium chain triglyceride, cocounut oil,
Olive oil, linseed oil are any one or more of.
It is highly preferred that above-mentioned technical proposal, the plants essential oil can be in cinnamon essential oil, lemon, vanilla essential oil
It is any one or more.
It is highly preferred that above-mentioned technical proposal, the protide emulsifier can separate egg for Whey Protein Concentrate, whey
White, soybean protein isolate, pea separation protein are any one or more of.
It is highly preferred that above-mentioned technical proposal, the polymethoxyflavone class compound can for Nobiletin, orange peel element,
Senensetin is any one or more of.
Second object of the present invention is to provide the system of the high instant microcapsule powder of carrying capacity polymethoxyflavone described above
Preparation Method, the method specifically comprise the following steps:
(1) functional grease, plants essential oil, polymethoxyflavone powder are mixed according to the ratio, heating stirring makes more methoxies
The dissolution of base flavones, is made oily phase；Protide emulsifier is dissolved in the water according to the ratio, water phase is made；
(2) oil is mutually mixed with water, high speed shear processing is dispersed to oil mutually in water phase, then will be finely dispersed
Sample carries out high-pressure homogeneous, and circulation homogeneous is to forming lotion；
(3) lotion is spray-dried to obtain microscapsule powder.
Preferably, above-mentioned technical proposal, step (1) heating temperature are 80~100 DEG C, and mixing time is 1~3h.
Preferably, the pressure of above-mentioned technical proposal, step (2) the high pressure homogenization processing is 40~80MPa, homogeneous secondary
Number is 4~6 times.
Preferably, above-mentioned technical proposal, the inlet air temperature of step (3) described spray drying are 160~200 DEG C, out wind-warm syndrome
Degree is 70~100 DEG C.
The present invention is with functional grease, polymethoxyflavone class compound, and plants essential oil is core material, is emulsified with protide
The reaction of agent wall material is prepared.The all raw material that the present invention uses is common raw-food material in life, the function
Property grease in be beneficial to health containing a large amount of unsaturated double-bond, can help to reduce cholesterol, prevention and treatment hyperlipidemia.Egg
White class emulsifier nutritive value with higher itself and its with good physiological activity, and rich in there is multiple active officials
It can roll into a ball, such as hydroxyl, carboxyl, amino.Used plants essential oil is all from the extract of plant spice, in plants essential oil
Aldehyde component can with the protein of adsorbed on interfaces occur azomethine react, the structure and environmental stability of interfacial film can be improved,
Promote the charging ratio of final microcapsule powder foot couple grease and nutrient.
Compared with prior art, the invention has the following beneficial effects:
(1) invention significantly improves the amounts of containing and stability of polymethoxyflavone class compound.
(2) solution rate of microcapsule powder produced by the present invention is very fast, and water with higher is in dispersibility and meltage.
(3) Manual Suture of the polymethoxyflavone class compound in the obtained microcapsule powder of the present invention obtains effectively
Improvement, this unit efficiency for significantly having saved cost, having improved product compared with the product of conventional method preparation.
(4) raw material that the present invention uses is food grade materials, is free of organic solvent, preparation condition is mild, production obtained
Product are not introduced into any food processing aid and poisonous and hazardous chemical substance, and use is safer, stable product quality, storage
It is longer to deposit the phase, can be widely used for food, health care product, drug, cosmetics.
Detailed description of the invention
Fig. 1 is the scanning electron microscope (SEM) photograph of microscapsule powder；Wherein: P1, P2, P3 are followed successively by made from comparative example 1~3 in figure A
Microcapsule powder；P1, P2, P3 are followed successively by microcapsule powder made from Examples 1 to 3 in figure B；
Fig. 2 is stability test effect picture of the microscapsule powder lotion in 0~8h；Wherein: A, B are followed successively by figure P1
Microcapsule powder made from comparative example 1, embodiment 1；A, B are followed successively by microcapsule powder made from comparative example 2, embodiment 2 in figure P2；
Fig. 3 is the Manual Suture comparison diagram of the lotion of microscapsule powder prepared by the embodiment of the present invention 1 and its preparation；
Wherein: E2.0, E2.0+CA represent lotion group；P2.0, P2.0+CA represent powder group.
Specific embodiment
Below with reference to case study on implementation and attached drawing, invention is further described in detail.The implementation case is with skill of the present invention
Implemented under premised on art, provides detailed embodiment and specific operating process now to illustrate that the present invention has and create
Property, but protection scope of the present invention case study on implementation not limited to the following.
The information for including according to the application, to those skilled in the art can be easily to essence of the invention
Really description carries out various changes, without departing from spirit and scope of the appended claims.It should be understood that the scope of the present invention
Process, property defined by being not limited to or component, because these embodiments and other descriptions are just for the sake of signal
Property illustrates certain aspects of the present disclosure.In fact, this field or those skilled in the relevant art can obviously implement the present invention
The various changes that mode is made all cover within the scope of the appended claims.
It is not intended to limit the scope of the invention for a better understanding of the present invention, expression dosage used in this application,
All numbers of percentage and other numerical value, are understood to be modified with word " about " in all cases.Cause
This, unless stated otherwise, otherwise digital parameters listed in specification and appended book are all approximations,
It may be changed according to the difference for the desirable properties for attempting to obtain.Each digital parameters at least should be considered as basis
It the effective digital reported and is obtained by the conventional method of rounding up.
Embodiment 1
A kind of high instant microcapsule powder of carrying capacity polymethoxyflavone of the present embodiment is grouped as by each group of following content:
The present embodiment high instant microcapsule powder of carrying capacity polymethoxyflavone described above is made with the following method, including such as
Lower step:
(1) prepare oily phase: by 9g soybean oil first with 1g cinnamon essential oil after mixing, 0.4g Nobiletin, heating is added
To 90 DEG C, 1h is persistently stirred, is kept the temperature after the Nobiletin in oily phase melts completely spare；
(2) prepare water phase: 4.5g Whey Protein Concentrate is added in 85.1g distilled water, persistently stirring 2h to albumen fills
Dispersion, stands overnight rear spare under the conditions of being then placed in 4 DEG C.
(3) it is mutually mixed oily with water phase, in ice bath, high speed shear 3min is to water phase under conditions of 12000rad/min
Mutually be sufficiently mixed with oil, after the sample that will be uniformly dispersed recycled homogeneous 5 times under conditions of the pressure of 62MPa, obtain even
Lotion is spare.
(4) nanoemulsions that will be obtained, at 180 DEG C of inlet temperature, 90 DEG C of outlet temperature, the item of charging rate 6mL/min
It is spray-dried to obtain microscapsule powder product, i.e. polymethoxyflavone instant powder under part.
Embodiment 2
A kind of high instant microcapsule powder of carrying capacity polymethoxyflavone of the present embodiment is grouped as by each group of following content:
The present embodiment high instant microcapsule powder of carrying capacity polymethoxyflavone described above is made with the following method, including such as
Lower step:
(1) prepare oily phase: by 19g soybean oil first with 1g cinnamon essential oil after mixing, 0.4g orange peel element, heating is added
To 90 DEG C, 1h is persistently stirred, is kept the temperature after the orange peel element in oily phase melts completely spare；
(2) prepare water phase: 7.2g soybean protein isolate is added in 72.4g distilled water, persistently stirring 2h to albumen fills
Dispersion, stands overnight rear spare under the conditions of being then placed in 4 DEG C.
(3) it is mutually mixed oily with water phase, in ice bath, high speed shear 3min is to water phase under conditions of 12000rad/min
Mutually be sufficiently mixed with oil, after the sample that will be uniformly dispersed recycled homogeneous 5 times under conditions of the pressure of 62MPa, obtain even
Lotion is spare.
(4) nanoemulsions that will be obtained, at 180 DEG C of inlet temperature, 90 DEG C of outlet temperature, the item of charging rate 6mL/min
It is spray-dried to obtain microscapsule powder product, i.e. polymethoxyflavone instant powder under part.
Embodiment 3
A kind of high instant microcapsule powder of carrying capacity polymethoxyflavone of the present embodiment is grouped as by each group of following content:
The present embodiment high instant microcapsule powder of carrying capacity polymethoxyflavone described above is made with the following method, including such as
Lower step:
(1) prepare oily phase: by 9g soybean oil first with 1g lemon after mixing, 0.4g Nobiletin, heating is added
To 90 DEG C, 1h is persistently stirred, is kept the temperature after the Nobiletin in oily phase melts completely spare；
(2) prepare water phase: 0.9g Whey Protein Concentrate is added in 88.7g distilled water, persistently stirring 2h to albumen fills
Dispersion, stands overnight rear spare under the conditions of being then placed in 4 DEG C.
(3) it is mutually mixed oily with water phase, in ice bath, high speed shear 3min is to water phase under conditions of 12000rad/min
Mutually be sufficiently mixed with oil, after the sample that will be uniformly dispersed recycled homogeneous 5 times under conditions of the pressure of 62MPa, obtain even
Lotion is spare.
(4) nanoemulsions that will be obtained, at 180 DEG C of inlet temperature, 90 DEG C of outlet temperature, the item of charging rate 6mL/min
It is spray-dried to obtain microscapsule powder product, i.e. polymethoxyflavone instant powder under part.
Embodiment 4
A kind of high instant microcapsule powder of carrying capacity polymethoxyflavone of the present embodiment is grouped as by each group of following content:
The present embodiment high instant microcapsule powder of carrying capacity polymethoxyflavone described above is made with the following method, including such as
Lower step:
(1) prepare oily phase: by 9g medium chain triglyceride first with 1g cinnamon essential oil after mixing, the river 0.75g dried orange peel is added
Element is heated to 90 DEG C, persistently stirs 1h, keeps the temperature after the orange peel element in oily phase melts completely spare；
(2) prepare water phase: 4.5g Whey Protein Concentrate is added in 84.75g distilled water, persistently stir 2h to albumen
It is fully dispersed, it is stood overnight under the conditions of being then placed in 4 DEG C rear spare.
(3) it is mutually mixed oily with water phase, in ice bath, high speed shear 3min is to water phase under conditions of 12000rad/min
Mutually be sufficiently mixed with oil, after the sample that will be uniformly dispersed recycled homogeneous 5 times under conditions of the pressure of 62MPa, obtain even
Lotion is spare.
(4) nanoemulsions that will be obtained, at 180 DEG C of inlet temperature, 90 DEG C of outlet temperature, the item of charging rate 6mL/min
It is spray-dried to obtain microscapsule powder product, i.e. polymethoxyflavone instant powder under part.
Comparative example 1
A kind of polymethoxyflavone microcapsule powder of this comparative example is grouped as by each group of following content:
Soybean oil (functional grease) 9g
Whey Protein Concentrate (emulsifier) 4.5g
Nobiletin (polymethoxyflavone class compound) 0.4g, the sum of each component mass percent are equal to 100%.
This comparative example polymethoxyflavone microcapsule powder described above is made with the following method, includes the following steps:
(1) prepare oily phase: 0.4g Nobiletin will be added in 9g soybean oil, be heated to 90 DEG C, persistently stir 1h, to oil
Nobiletin in phase keeps the temperature spare after melting completely；
(2) prepare water phase: 4.5g Whey Protein Concentrate is added in 85.1g distilled water, persistently stirring 2h to albumen fills
Dispersion, stands overnight rear spare under the conditions of being then placed in 4 DEG C.
(3) it is mutually mixed oily with water phase, in ice bath, high speed shear 3min is to water phase under conditions of 12000rad/min
Mutually be sufficiently mixed with oil, after the sample that will be uniformly dispersed recycled homogeneous 5 times under conditions of the pressure of 62MPa, obtain even
Lotion is spare.
(4) nanoemulsions that will be obtained, at 180 DEG C of inlet temperature, 90 DEG C of outlet temperature, the item of charging rate 6mL/min
It is spray-dried to obtain microscapsule powder product, i.e. polymethoxyflavone powder under part.
Comparative example 2
A kind of polymethoxyflavone microcapsule powder of this comparative example is grouped as by each group of following content:
Soybean oil (functional grease) 19g
Soybean protein isolate (emulsifier) 7.2g
Orange peel element (polymethoxyflavone class compound) 0.4g, the sum of each component mass percent are equal to 100%.
The present embodiment polymethoxyflavone microcapsule powder described above is made with the following method, includes the following steps:
(1) prepare oily phase: 0.4g orange peel element will be added in 19g soybean oil, be heated to 90 DEG C, persistently stir 1h, to oily phase
In orange peel element completely melt after keep the temperature it is spare；
(2) prepare water phase: 7.2g soybean protein isolate is added in 72.4g distilled water, persistently stirring 2h to albumen fills
Dispersion, stands overnight rear spare under the conditions of being then placed in 4 DEG C.
(3) it is mutually mixed oily with water phase, in ice bath, high speed shear 3min is to water phase under conditions of 12000rad/min
Mutually be sufficiently mixed with oil, after the sample that will be uniformly dispersed recycled homogeneous 5 times under conditions of the pressure of 62MPa, obtain even
Lotion is spare.
(4) nanoemulsions that will be obtained, at 180 DEG C of inlet temperature, 90 DEG C of outlet temperature, the item of charging rate 6mL/min
It is spray-dried to obtain microscapsule powder product, i.e. polymethoxyflavone instant powder under part.
Comparative example 3
A kind of polymethoxyflavone microcapsule powder of this comparative example is grouped as by each group of following content:
Soybean oil (functional grease) 9g
Whey Protein Concentrate (emulsifier) 0.9g
Nobiletin (polymethoxyflavone class compound) 0.4g, the sum of each component mass percent are equal to 100%.
The present embodiment polymethoxyflavone microcapsule powder described above is made with the following method, includes the following steps:
(1) prepare oily phase: 0.4g Nobiletin being added into 9g soybean oil, is heated to 90 DEG C, persistently stirs 1h, to oil
Nobiletin in phase keeps the temperature spare after melting completely；
(2) prepare water phase: 0.9g Whey Protein Concentrate is added in 88.7g distilled water, persistently stirring 2h to albumen fills
Dispersion, stands overnight rear spare under the conditions of being then placed in 4 DEG C.
(3) it is mutually mixed oily with water phase, in ice bath, high speed shear 3min is to water phase under conditions of 12000rad/min
Mutually be sufficiently mixed with oil, after the sample that will be uniformly dispersed recycled homogeneous 5 times under conditions of the pressure of 62MPa, obtain even
Lotion is spare.
(4) nanoemulsions that will be obtained, at 180 DEG C of inlet temperature, 90 DEG C of outlet temperature, the item of charging rate 6mL/min
It is spray-dried to obtain microscapsule powder product, i.e. polymethoxyflavone instant powder under part.
Comparative example 4
A kind of polymethoxyflavone microcapsule powder of this comparative example is grouped as by each group of following content:
Medium chain triglyceride (functional grease) 9g
Whey Protein Concentrate (emulsifier) 4.5g
Nobiletin (polymethoxyflavone class compound) 0.75g, the sum of each component mass percent are equal to 100%.
The present embodiment polymethoxyflavone microcapsule powder described above is made with the following method, includes the following steps:
(1) prepare oily phase: 0.75g Nobiletin being added into 9g medium chain triglyceride, is heated to 90 DEG C, it is lasting to stir
1h is kept the temperature spare after the orange peel element in oily phase melts completely；
(2) prepare water phase: 4.5g Whey Protein Concentrate is added in 84.75g distilled water, persistently stir 2h to albumen
It is fully dispersed, it is stood overnight under the conditions of being then placed in 4 DEG C rear spare.
(3) it is mutually mixed oily with water phase, in ice bath, high speed shear 3min is to water phase under conditions of 12000rad/min
Mutually be sufficiently mixed with oil, after the sample that will be uniformly dispersed recycled homogeneous 5 times under conditions of the pressure of 62MPa, obtain even
Lotion is spare.
(4) nanoemulsions that will be obtained, at 180 DEG C of inlet temperature, 90 DEG C of outlet temperature, the item of charging rate 6mL/min
It is spray-dried to obtain microscapsule powder product, i.e. polymethoxyflavone instant powder under part.
Performance test:
Fig. 1 is the scanning electron microscope (SEM) photograph of the microscapsule powder of the present invention and comparative example preparation；Wherein: figure A in P1, P2, P3 according to
Secondary is microcapsule powder made from comparative example 1~3；Scheme P1 in B, P2, P3 are followed successively by microcapsule powder made from Examples 1 to 3.From
Figure B powder morphology can be seen that powder sample produced by the present invention dispersibility preferably and can independent granulating, do not advise mostly
Then ball-type, surface is smooth, flawless and significant hole.Crystal habit discovery is compared, the sample without plants essential oil (is implemented
Example 3) in crystallization tubbiness, have apparent section trace, the crystallization in the sample (embodiment 1, embodiment 2) containing plants essential oil is more
It is elongated and without apparent section trace.
The charging ratio of microscapsule powder product made from the above embodiment of the present invention 1~4, instant capacity, stability are carried out
Test, test result are as shown in table 1.
Charging ratio refers to the percentage that core material is loaded in the solid microcapsules of certain mass, charging ratio=(microcapsules inner core
Material amount/microcapsules gross mass) × 100%.
Instant capacity test method is as follows: weighing 5g sample and is put in 100mL beaker, 25 DEG C of deionized water is then added
50mL is stirred in constant temperature blender with magnetic force with the revolving speed of 450rad/min, and record all disperses institute to powder since stirring
The time (s) needed.(instant capacity test method is as follows referring to method: 1. Wang Lei, Lan Yuqian, Jessica Lynch's drying process with atomizing pair
The influence of rice-chestnut powder instant capacity, 2. woods expands logical milk powder manufacturing engineering [M] Tao Yunzhang to Food Science .2010., translates the Beijing: light
Industrial publishing house, 1987:89.)
Stability test method is as follows: being reconstituted with 25 DEG C of water to microscapsule powder, obtains 10% Polymethoxylated Huang
There is the time of emulsifiable paste in ketone microcapsule powder lotion, at the uniform velocity stirring lotion, start recording time, observation lotion surface.
When carrying out instant capacity and stability test to powder, it can be seen that microscapsule powder product produced by the present invention
Instant effect can reach preferable level, and comparison stability result is it can be found that sample made from comparative example is passing through 5h
Standing after upper layer there is apparent emulsifiable paste layer, and microcapsule emulsion produced by the present invention occurs without apparent emulsifiable paste layer,
As shown in Figure 2.
Charging ratio, instant capacity, the stability test result table of microscapsule powder product made from 1 Examples 1 to 4 of table
Manual Suture is absorbability when flavone compound is discharged from food matrix in the gastrointestinal tract.The present invention
The Manual Suture of polymethoxyflavone instant powder obtained is tested, test results are shown in figure 3.It can from Fig. 3
To find out, the addition of plants essential oil improves the Manual Suture of polymethoxyflavone to a certain extent, and by lotion powder
The promotion of the Manual Suture of polymethoxyflavone is also beneficial to after endization.
Claims (9)
1. a kind of high instant microcapsule powder of carrying capacity polymethoxyflavone, it is characterised in that: by each of following mass percentage content
At being grouped as:
2. the high instant microcapsule powder of carrying capacity polymethoxyflavone according to claim 1, it is characterised in that: by following quality hundred
It is point more each at being grouped as than content:
3. the high instant microcapsule powder of carrying capacity polymethoxyflavone according to claim 1, it is characterised in that: the functional oil
Rouge is soybean oil, medium chain triglyceride, cocounut oil, olive oil, and linseed oil is any one or more of.
4. the high instant microcapsule powder of carrying capacity polymethoxyflavone according to claim 1, it is characterised in that: the plants essential oil
It is any one or more of for cinnamon essential oil, lemon, vanilla essential oil.
5. the high instant microcapsule powder of carrying capacity polymethoxyflavone according to claim 1, it is characterised in that: the protide cream
Agent is that Whey Protein Concentrate, whey protein isolate, soybean protein isolate, pea separation protein are any one or more of.
6. the high instant microcapsule powder of carrying capacity polymethoxyflavone according to claim 1, it is characterised in that: described Polymethoxylated
Flavone compound is Nobiletin, orange peel is plain, senensetin is any one or more of.
7. the preparation method of the described in any item high instant microcapsule powders of carrying capacity polymethoxyflavone of claim 1~6, feature
Be: the method specifically comprises the following steps:
(1) functional grease, plants essential oil, polymethoxyflavone powder are mixed according to the ratio, heating stirring makes Polymethoxylated Huang
Ketone dissolution, is made oily phase；Emulsifier is dissolved in the water according to the ratio, water phase is made；
(2) oil is mutually mixed with water, high speed shear processing is dispersed to oil mutually in water phase, then by finely dispersed sample
Carry out high-pressure homogeneous, circulation homogeneous is to forming lotion；
(3) lotion is spray-dried to obtain microscapsule powder.
8. the preparation method of the high instant microcapsule powder of carrying capacity polymethoxyflavone according to claim 7, it is characterised in that:
The pressure of step (2) the high pressure homogenization processing is 40~80MPa, and homogeneous number is 4~6 times.
9. the preparation method of the high instant microcapsule powder of carrying capacity polymethoxyflavone according to claim 7, it is characterised in that:
The inlet air temperature of step (3) described spray drying is 160~200 DEG C, and leaving air temp is 70~100 DEG C.
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