CN111345904A - Heart fixing device for small animal heart confocal imaging - Google Patents
Heart fixing device for small animal heart confocal imaging Download PDFInfo
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- CN111345904A CN111345904A CN202010129972.6A CN202010129972A CN111345904A CN 111345904 A CN111345904 A CN 111345904A CN 202010129972 A CN202010129972 A CN 202010129972A CN 111345904 A CN111345904 A CN 111345904A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/40—Animals
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Abstract
The invention relates to a heart fixing device for confocal imaging of a small animal heart, which comprises a transparent bottom plate, a piston tube and a piston, wherein a groove body is formed in the bottom of the transparent bottom plate, the piston tube penetrates through the top of the transparent bottom plate and extends into the groove body, the piston is arranged in the piston tube, and the heart for an experiment is fixed between the piston and an experiment table. Compared with the prior art, the invention has simple structure and convenient operation, can fix the heart for experiment by manually pushing and pulling the piston, and avoids the adverse effect of the heart beating on the heart confocal imaging.
Description
Technical Field
The invention belongs to the technical field of organ imaging fixing devices, and relates to a heart fixing device for small animal confocal cardiac imaging.
Background
Isolated heart is a common model for studying cardiac function, and the demand for perfusion cardiac imaging is increasing. In order to maintain the function of the heart, the heart is in a perfusion state in vitro, the focus of a microscope is affected when the beating heart is imaged, even if a drug for inhibiting the beating of the heart is added into a perfusion solution, the myocardium still beats to a certain extent, the focus of the heart is affected by the flow of the perfusion solution, and a clear image cannot be obtained.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a heart fixing device for small animal confocal cardiac imaging, which is used for solving the problem of unclear confocal cardiac imaging caused by experimental cardiac pulsation.
The purpose of the invention can be realized by the following technical scheme:
a heart fixing device for small animal confocal cardiac imaging is arranged on an experiment table and comprises a transparent bottom plate, a piston tube and a piston;
the bottom of the transparent bottom plate is provided with a groove body;
the piston pipe penetrates through the top of the transparent bottom plate and extends into the groove body;
the piston is arranged in the piston pipe;
the experimental heart is fixed between the piston and the experiment table.
According to the size of the heart for the experiment, the position of the piston in the piston tube is adjusted through moving up and down, so that the heart for the experiment is fixed between the piston and the experiment table, and the influence of the heart beating on the heart confocal imaging definition is avoided.
Furthermore, the piston comprises a piston head, a piston shaft and a piston handle which are sequentially connected from bottom to top along the axial direction of the piston pipe.
The experimental heart is specifically fixed between the piston head and the experiment table, and the position of the piston head in the piston tube can be adjusted by manually pushing and pulling the piston handle so as to adapt to the sizes of different experimental hearts.
Further, the piston tube is a transparent piston tube, so that representation of confocal cardiac imaging is facilitated.
Further, the piston pipe is arranged in the center of the top of the transparent bottom plate.
Furthermore, a gap of 8-15mm is arranged between the lower end of the piston tube and the experiment table and is used for providing a space for the inclined arrangement of the perfusion heart and the placement of the perfusion tube.
Furthermore, the side surface of the transparent groove body is provided with a side surface opening communicated with the groove body, and the side surface opening is used as an inlet and an outlet of the heart perfusion tubule.
Furthermore, the side opening extends to the top and the bottom of the transparent bottom plate, so that the angle adjustment of the heart perfusion tubule and the building of the test device are facilitated.
Furthermore, the cross section of the side opening is V-shaped.
The working principle is as follows: according to the size of the experimental heart, the position of the bottom of the piston head extending out of the piston tube is adjusted by manually pushing and pulling the piston handle so as to adapt to the sizes of different experimental hearts, so that the experimental heart is fixed between the piston head and an experiment table, and the influence of the heart beating on the heart confocal imaging definition is avoided.
Compared with the prior art, the invention has the following characteristics:
1) the invention has simple structure and convenient operation, can fix the heart for experiment by manually pushing and pulling the piston, and avoids the adverse effect of the heart beating on the heart confocal imaging;
2) stepless adjustment of fixed height can be realized by moving the piston so as to adapt to isolated hearts of different sizes.
Drawings
FIG. 1 is a schematic structural view of a small animal confocal cardiac imaging cardiac fixation device according to the present invention;
the notation in the figure is:
1-transparent bottom plate, 2-piston tube, 3-piston, 301-piston head, 302-piston shaft, 303-piston handle, 4-opening.
Detailed Description
The invention is described in detail below with reference to the figures and specific embodiments. The present embodiment is implemented on the premise of the technical solution of the present invention, and a detailed implementation manner and a specific operation process are given, but the scope of the present invention is not limited to the following embodiments.
Example 1:
fig. 1 shows a heart fixing device for confocal cardiac imaging of a small animal, which is arranged on a laboratory bench and comprises a transparent bottom plate 1, a piston tube 2 and a piston 3;
wherein, the bottom of the transparent bottom plate 1 is provided with a groove body; the piston tube 2 is a transparent piston tube, the transparent piston tube penetrates through the center of the top of the transparent bottom plate 1 and extends into the groove body, and a 12mm gap is also arranged between the lower end of the piston tube 2 and the experiment table; the piston 3 comprises a piston head 301, a piston shaft 302 and a piston handle 303 which are sequentially connected from bottom to top along the axial direction of the piston tube 2, and the piston head 301 is arranged in the piston tube 2.
In addition, the side surface of the transparent groove body 1 is provided with a side opening 4 which is communicated with the groove body and has a V-shaped cross section, and the side opening 4 extends up and down to the top and the bottom of the transparent bottom plate 1.
The working principle is as follows: according to the size of the experimental heart, the position of the bottom of the piston head 301 extending out of the piston tube 2 is adjusted by manually pushing and pulling the piston handle 303 to adapt to the sizes of different experimental hearts, so that the experimental heart is fixed between the piston head 301 and an experiment table, and the influence of the heart beating on the heart confocal imaging definition is avoided.
Example 2:
in this embodiment, a clearance of 15mm is provided between the lower end of the piston tube 2 and the test table, which is the same as in embodiment 1.
Example 3:
in this embodiment, a clearance of 8mm is provided between the lower end of the piston tube 2 and the test table, which is the same as in embodiment 1.
The embodiments described above are described to facilitate an understanding and use of the invention by those skilled in the art. It will be readily apparent to those skilled in the art that various modifications to these embodiments may be made, and the generic principles described herein may be applied to other embodiments without the use of the inventive faculty. Therefore, the present invention is not limited to the above embodiments, and those skilled in the art should make improvements and modifications within the scope of the present invention based on the disclosure of the present invention.
Claims (8)
1. A heart fixing device for small animal confocal cardiac imaging is arranged on an experiment table and is characterized by comprising a transparent bottom plate (1), a piston tube (2) and a piston (3);
the bottom of the transparent bottom plate (1) is provided with a groove body;
the piston tube (2) penetrates through the top of the transparent bottom plate (1) and extends into the groove body;
the piston (3) is arranged in the piston pipe (2);
the experimental heart is fixed between the piston (3) and the experimental table.
2. The heart fixing device for confocal small animal cardiac imaging according to claim 1, wherein the piston (3) comprises a piston head (301), a piston shaft (302) and a piston handle (303) which are sequentially connected from bottom to top along the axial direction of the piston tube (2).
3. The heart fixation device for confocal small animal cardiac imaging according to claim 2, wherein the piston tube (2) is a transparent piston tube.
4. The heart fixation device for confocal small animal cardiac imaging according to claim 1, wherein the piston tube (2) is disposed at the center of the top of the transparent base plate (1).
5. The heart fixing device for confocal small animal cardiac imaging according to claim 1, wherein a gap of 8-15mm is provided between the lower end of the piston tube (2) and the experiment table.
6. The heart fixing device for the confocal small animal cardiac imaging according to claim 1, wherein a side opening (4) communicated with the groove body is formed in the side surface of the transparent groove body (1).
7. The heart fixation device for confocal small animal cardiac imaging according to claim 6, wherein the side openings (4) extend to the top and bottom of the transparent base plate (1).
8. The small animal confocal cardiac imaging cardiac fixation device as claimed in claim 1, wherein the lateral opening (4) has a V-shaped cross-section.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010129972.6A CN111345904A (en) | 2020-02-28 | 2020-02-28 | Heart fixing device for small animal heart confocal imaging |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010129972.6A CN111345904A (en) | 2020-02-28 | 2020-02-28 | Heart fixing device for small animal heart confocal imaging |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111345904A true CN111345904A (en) | 2020-06-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010129972.6A Pending CN111345904A (en) | 2020-02-28 | 2020-02-28 | Heart fixing device for small animal heart confocal imaging |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2553214A2 (en) * | 1983-01-24 | 1985-04-12 | Bex Jean Pierre | Training device intended for surgeons in particular |
| CN203234862U (en) * | 2012-12-12 | 2013-10-16 | 江南大学 | Rat heart perfusion fixing device |
| CN203425059U (en) * | 2013-07-17 | 2014-02-12 | 上海市同济医院 | Rat heart perfusion fixation device |
| CN204288659U (en) * | 2014-12-25 | 2015-04-22 | 佳木斯大学 | A kind of Novel scissors blade rat heart perfusion fixator |
| CN106725983A (en) * | 2017-03-02 | 2017-05-31 | 中国人民解放军第三军医大学第二附属医院 | Experimental animal fixing device |
| CN206730008U (en) * | 2016-12-22 | 2017-12-12 | 山西农业大学 | A kind of laboratory rat mouse heart irrigates fixing device |
| US20180338806A1 (en) * | 2017-05-24 | 2018-11-29 | KindHeart, Inc. | Surgical simulation system using force sensing and optical tracking and robotic surgery system |
-
2020
- 2020-02-28 CN CN202010129972.6A patent/CN111345904A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2553214A2 (en) * | 1983-01-24 | 1985-04-12 | Bex Jean Pierre | Training device intended for surgeons in particular |
| CN203234862U (en) * | 2012-12-12 | 2013-10-16 | 江南大学 | Rat heart perfusion fixing device |
| CN203425059U (en) * | 2013-07-17 | 2014-02-12 | 上海市同济医院 | Rat heart perfusion fixation device |
| CN204288659U (en) * | 2014-12-25 | 2015-04-22 | 佳木斯大学 | A kind of Novel scissors blade rat heart perfusion fixator |
| CN206730008U (en) * | 2016-12-22 | 2017-12-12 | 山西农业大学 | A kind of laboratory rat mouse heart irrigates fixing device |
| CN106725983A (en) * | 2017-03-02 | 2017-05-31 | 中国人民解放军第三军医大学第二附属医院 | Experimental animal fixing device |
| US20180338806A1 (en) * | 2017-05-24 | 2018-11-29 | KindHeart, Inc. | Surgical simulation system using force sensing and optical tracking and robotic surgery system |
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Application publication date: 20200630 |