CN111298201A - Medical lubricant and preparation method thereof - Google Patents
Medical lubricant and preparation method thereof Download PDFInfo
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- CN111298201A CN111298201A CN202010159694.9A CN202010159694A CN111298201A CN 111298201 A CN111298201 A CN 111298201A CN 202010159694 A CN202010159694 A CN 202010159694A CN 111298201 A CN111298201 A CN 111298201A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/041—Mixtures of macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/452—Lubricants
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- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
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Abstract
The invention relates to the technical field related to lubricants, and particularly provides a medical lubricant. The invention provides a medical water-soluble lubricant, which is prepared from polyethylene glycol, hyaluronic acid, carbomer, small-molecular polyol, a pH regulator and purified water. The medical lubricant which is uniformly dispersed, transparent, easy to apply and smooth is prepared by adopting the combined action of the specific carbomer and the polyethylene glycol, and meanwhile, the lubricant has better moisturizing performance and is beneficial to stable and long-term storage.
Description
Technical Field
The invention relates to the technical field related to lubricants, and particularly provides a medical lubricant.
Background
The medical lubricant is a water gel, a mucilage and mineral oil which provide auxiliary lubrication for various instruments in the process of clinical diagnosis and treatment or operation, and is mainly used for lubricating an intubation tube or an endoscope of a natural cavity of a human body, lubricating an operation suture, lubricating gynecological examination instruments, lubricating an anastomat and the like.
In order to clinically confirm various intracavity diseases, various cavity endoscopes are widely used, and during the process that the medical instruments (such as endoscopes, colposcopes, cervical clamps, medical catheters and other diagnostic instruments) enter the cavities of human bodies, a proper amount of lubricant is often required to be coated on the surfaces of the medical instruments so as to reduce the damage of the instruments to the tissues of the human bodies. The lubricant is required to play a certain anesthetic effect firstly, has no corrosion to a mirror body, good self stability, small irritation to a patient, no toxicity or side effect, and has the effects of anesthesia, disinfection, defoaming and the like on the surface of the mucosa of the cavity.
At present, in clinical practical application, the lubricant for the endoscope of the cavity has single performance, and mostly adopts silicone oil, glycerol, liquid paraffin and the like, but the medicines only have the lubricating effect, do not have local anesthesia and good lubricating property, and are difficult to accept by patients. In clinical use, the silicone oil is found to be unevenly dispersed, the preparation is sticky, poor and uneven in water solubility and insufficient in transparency, and after the silicone oil is used, the silicone oil is easy to form block-solid sticky substances which are attached to the walls of digestive tracts and the like and can shield focus parts instead, so that the inspection accuracy or omission is influenced.
Disclosure of Invention
In order to solve the technical problems, the invention provides a medical water-soluble lubricant in a first aspect, which is prepared from polyethylene glycol, hyaluronic acid, carbomer, small-molecular polyol, a pH regulator and purified water; preferably, the water-soluble lubricant comprises the following preparation raw materials, by weight, 20-35 parts of polyethylene glycol, 3-8 parts of hyaluronic acid, 1-5 parts of carbomer, 12-19 parts of small-molecule polyol, 0.3-1.5 parts of a pH regulator and 75-100 parts of purified water; further preferably, the water-soluble lubricant comprises the following preparation raw materials, by weight, 26-29 parts of polyethylene glycol, 4-7 parts of hyaluronic acid, 2-4 parts of carbomer, 15-17 parts of small-molecule polyol, 0.3-1.5 parts of a pH regulator and 80-92 parts of purified water; more preferably, the water-soluble lubricant comprises the following preparation raw materials, by weight, 27 parts of polyethylene glycol, 6.2 parts of hyaluronic acid, 3.5 parts of carbomer, 16.6 parts of small-molecule polyol, 0.3-1.5 parts of pH regulator and 88 parts of purified water.
The carbomer is a high-molecular polymer of acrylic acid bonded allyl sucrose or pentaerythritol allyl ether, and the carboxylic group content of the carbomer is 56-68 wt%; the invention is selected from any one or more of carbomer 940, carbomer 941, carbomer 934, carbomer 91342, carbomer 980, carbomer EDT 2020, carbomer AQUA SF-1, carbomer Ultrez 21, carbomer Ultrez 20; preferably, carbomers include carbomer 941, carbomer 980, and carbomer AQUA SF-1; further preferably, the weight ratio of carbomer 941, carbomer 980 and carbomer AQUA SF-1 is 1: (0.35-0.65): (0.1 to 0.3); more preferably, the weight ratio of carbomer 941, carbomer 980 and carbomer AQUA SF-1 is 1: 0.47: 0.26.
carbomer 941 has the characteristics of long rheology, low viscosity and high color clarity, carbomer 980 is cross-linked acrylate and is well dissolved in a water or alcohol system, and carbomer AQUA SF-1 is a long-rheology liquid material, and when the carbomer 941 and carbomer 980 are jointly used, the carbomer is in synergistic effect with other components in the system, so that the compatibility of lubricating liquid is favorably improved, the viscosity of the system is enabled to be higher than 12000mpa.s, the better spreading and wetting effects are still realized, and the better wettability of the carbomer on the surface of a medical instrument and the surface of skin is also improved.
Polyethylene glycol is formed by gradually adding and polymerizing ethylene oxide and water or ethylene glycol, and has different properties according to different relative molecular masses. The polyethylene glycol is selected from any one or combination of more of PEG-400, PEG-600, PEG-800, PEG-1000, PEG-1200, PEG-1500, PEG-2000, PEG-4000, PEG-2000, PEG-6000, PEG-8000 and PEG-400; preferably, the polyethylene glycol comprises PEG-400, PEG-1500, PEG-4000; further preferably, the weight ratio of PEG-400, PEG-1500 and PEG-4000 is 1: (0.2-0.45): (0.35-0.55); more preferably, the weight ratio of PEG-400, PEG-1500 and PEG-4000 is 1: 0.33: 0.45, PEG-400, PEG-1500, PEG-4000 in the weight ratio of 1: (0.2-0.45): (0.35-0.55) the weight of the lubricant and other substances in the system act together, so that the stability and the spreading performance of the lubricant can be effectively improved, the lubricant is a non-ionic water-soluble polymer, PEG with different molecular weights is adopted, the polarity of the PEG is also in a gradient manner, the lubricant has good compatibility with other substances in the system, and meanwhile, the lubricant has good water absorption property, the lubricant has good water retention property in the storage process, and the problem that the lubricant cannot be stored for a long time due to water loss is avoided.
The small molecule polyol of the invention is a small molecule polyol of resin of a person skilled in the art, such as any one or combination of glycerol, ethylene glycol, propylene glycol, butylene glycol, erythritol, xylitol, D-sorbitol and inositol.
In some embodiments, the preparation raw materials further include an amine compound, and the weight ratio of the amine compound to the polyethylene glycol is (0.33-0.65): 1; preferably, the weight ratio of the amine compound to the polyethylene glycol is (0.42-0.58): 1; more preferably, the weight ratio of amine compound to polyethylene glycol is 0.48: 1.
the amine compound is quaternary ammonium salt; such as single-chain quaternary ammonium salt, double-chain quaternary ammonium salt, compound quaternary ammonium salt and polyquaternary ammonium salt, the type of the quaternary ammonium salt is not particularly limited, in one embodiment, the quaternary ammonium salt is hydroxypropyl trimethyl ammonium chloride chitosan, and the purchasing manufacturer of the quaternary ammonium salt is not particularly limited.
The pH adjuster is an alkaline solution, and is not particularly limited, and in one embodiment, the pH adjuster is sodium hydroxide.
In some embodiments, the pH of the water-soluble lubricant for medical use is 6.0 to 7.5.
In some embodiments, the medical water-soluble lubricant has a viscosity of greater than 12000mpa.s at 25 ℃.
The second aspect of the present invention provides a preparation method of the medical water-soluble lubricant, comprising the following steps:
(1) blending polyethylene glycol, hyaluronic acid and small molecular polyol;
(2) mixing the poloxamer with purified water; then stirring and mixing with the substance obtained in the step (1);
(3) and (3) adding a pH regulator into the system obtained in the step (2), stirring and mixing, and sterilizing to obtain the aqueous lubricant.
Preferably, the preparation method of the medical water-soluble lubricant comprises the following steps:
(1) blending polyethylene glycol, hyaluronic acid and small molecular polyol;
(2) mixing the poloxamer with purified water; then stirring and mixing with the substance obtained in the step (1);
(3) adding an amine compound into the system obtained in the step (2), and stirring and mixing;
(4) adding a pH regulator into the system obtained in the step (3), stirring and mixing, and regulating the pH to 7.0; sterilizing to obtain the water-based lubricant.
The third aspect of the invention provides the use of the medical water-soluble lubricant for gastroscopy and enteroscopy.
Compared with the prior art, the medical lubricant which is uniformly dispersed, transparent, easy to smear and smooth is prepared by adopting the combined action of the specific carbomer and the polyethylene glycol, and meanwhile, the lubricant has better moisturizing performance and is beneficial to stable and long-term storage.
Detailed Description
The technical features of the technical solutions provided by the present invention are further clearly and completely described below with reference to the specific embodiments, and the scope of protection is not limited thereto.
Example 1
The embodiment 1 of the invention provides a medical water-soluble lubricant, which comprises the following preparation raw materials, by weight, 20 parts of polyethylene glycol, 3.2 parts of hyaluronic acid, 1.3 parts of carbomer, 12.5 parts of small-molecular polyol, a pH regulator and 75 parts of purified water;
the carbomer comprises carbomer 941, carbomer 980 and carbomer AQUA SF-1, wherein the weight ratio of the carbomer 941 to the carbomer 980 to the carbomer AQUA SF-1 is 1: 0.35: 0.1;
the polyethylene glycol comprises PEG-400, PEG-1500 and PEG-4000, and the weight ratio of the PEG-400 to the PEG-1500 to the PEG-4000 is 1: 0.2: 0.35;
the small molecular polyol is glycerol; the pH regulator is sodium hydroxide;
the preparation raw materials also comprise amine compounds, wherein the amine compounds are hydroxypropyl trimethyl ammonium chloride chitosan and are purchased from Shandong Fengtai BioLimited science and technology company; the weight ratio of the amine compound to the polyethylene glycol is 0.33: 1
The preparation method of the medical water-soluble lubricant comprises the following steps:
(1) blending polyethylene glycol, hyaluronic acid and small molecular polyol;
(2) mixing the poloxamer with purified water; then stirring and mixing with the substance obtained in the step (1);
(3) adding an amine compound into the system obtained in the step (2), and stirring and mixing;
(4) adding a pH regulator into the system obtained in the step (3), stirring and mixing, and regulating the pH to 7.0; sterilizing to obtain the water-based lubricant.
Example 2
Embodiment 2 of the present invention provides a medical water-soluble lubricant, which comprises the following preparation raw materials, by weight, 35 parts of polyethylene glycol, 7.8 parts of hyaluronic acid, 4.9 parts of carbomer, 18.8 parts of small-molecule polyol, a pH regulator, and 95 parts of purified water;
the carbomer comprises carbomer 941, carbomer 980 and carbomer AQUA SF-1, wherein the weight ratio of the carbomer 941 to the carbomer 980 to the carbomer AQUA SF-1 is 1: 0.65: 0.3;
the polyethylene glycol comprises PEG-400, PEG-1500 and PEG-4000, and the weight ratio of the PEG-400 to the PEG-1500 to the PEG-4000 is 1: 0.45: 0.55;
the small molecular polyol is glycerol; the pH regulator is sodium hydroxide;
the preparation raw materials also comprise amine compounds, wherein the amine compounds are hydroxypropyl trimethyl ammonium chloride chitosan and are purchased from Shandong Fengtai BioLimited science and technology company; the weight ratio of the amine compound to the polyethylene glycol is 0.65: 1
The preparation method of the medical water-soluble lubricant is the same as that of example 1.
Example 3
Embodiment 3 of the present invention provides a medical water-soluble lubricant, which comprises the following preparation raw materials, by weight, 27 parts of polyethylene glycol, 6.2 parts of hyaluronic acid, 3.5 parts of carbomer, 16.6 parts of small-molecule polyol, a pH regulator, and 88 parts of purified water;
the carbomer comprises carbomer 941, carbomer 980 and carbomer AQUA SF-1, wherein the weight ratio of the carbomer 941 to the carbomer 980 to the carbomer AQUA SF-1 is 1: 0.47: 0.26;
the polyethylene glycol comprises PEG-400, PEG-1500 and PEG-4000, and the weight ratio of the PEG-400 to the PEG-1500 to the PEG-4000 is 1: 0.33: 0.45 of;
the small molecular polyol is glycerol; the pH regulator is sodium hydroxide;
the preparation raw materials also comprise amine compounds, wherein the amine compounds are hydroxypropyl trimethyl ammonium chloride chitosan and are purchased from Shandong Fengtai BioLimited science and technology company; the weight ratio of the amine compound to the polyethylene glycol is 0.48: 1
The preparation method of the medical water-soluble lubricant is the same as that of example 1.
Example 4
Embodiment 4 of the present invention provides a medical water-soluble lubricant, which comprises the following preparation raw materials, by weight, 27 parts of polyethylene glycol, 6.2 parts of hyaluronic acid, 3.5 parts of carbomer, 16.6 parts of small-molecule polyol, a pH regulator, and 88 parts of purified water;
the carbomer comprises carbomer 941 and carbomer AQUA SF-1, wherein the weight ratio of carbomer 941 to carbomer AQUA SF-1 is 1: 0.26;
the polyethylene glycol comprises PEG-400, PEG-1500 and PEG-4000, and the weight ratio of the PEG-400 to the PEG-1500 to the PEG-4000 is 1: 0.33: 0.45 of;
the small molecular polyol is glycerol; the pH regulator is sodium hydroxide;
the preparation raw materials also comprise amine compounds, wherein the amine compounds are hydroxypropyl trimethyl ammonium chloride chitosan and are purchased from Shandong Fengtai BioLimited science and technology company; the weight ratio of the amine compound to the polyethylene glycol is 0.48: 1
The preparation method of the medical water-soluble lubricant is the same as that of example 1.
Example 5
Embodiment 5 of the present invention provides a medical water-soluble lubricant, comprising the following preparation raw materials, by weight, 27 parts of polyethylene glycol, 6.2 parts of hyaluronic acid, 3.5 parts of carbomer, 16.6 parts of small-molecule polyol, a pH regulator, and 88 parts of purified water;
carbomer includes carbomer 941, carbomer 980, and carbomer 941, carbomer 980's weight ratio is 1: 0.47;
the polyethylene glycol comprises PEG-400, PEG-1500 and PEG-4000, and the weight ratio of the PEG-400 to the PEG-1500 to the PEG-4000 is 1: 0.33: 0.45 of;
the small molecular polyol is glycerol; the pH regulator is sodium hydroxide;
the preparation raw materials also comprise amine compounds, wherein the amine compounds are hydroxypropyl trimethyl ammonium chloride chitosan and are purchased from Shandong Fengtai BioLimited science and technology company; the weight ratio of the amine compound to the polyethylene glycol is 0.48: 1
The preparation method of the medical water-soluble lubricant is the same as that of example 1.
Example 6
Embodiment 6 of the present invention provides a medical water-soluble lubricant, which comprises the following preparation raw materials, by weight, 27 parts of polyethylene glycol, 6.2 parts of hyaluronic acid, 3.5 parts of carbomer, 16.6 parts of small-molecule polyol, a pH regulator, and 88 parts of purified water;
the carbomer comprises carbomer 941, carbomer 980 and carbomer AQUA SF-1, wherein the weight ratio of the carbomer 941 to the carbomer 980 to the carbomer AQUA SF-1 is 1: 0.47: 0.26;
the polyethylene glycol comprises PEG-400 and PEG-4000, and the weight ratio of the PEG-400 to the PEG-4000 is 1: 0.45 of;
the small molecular polyol is glycerol; the pH regulator is sodium hydroxide;
the preparation raw materials also comprise amine compounds, wherein the amine compounds are hydroxypropyl trimethyl ammonium chloride chitosan and are purchased from Shandong Fengtai BioLimited science and technology company; the weight ratio of the amine compound to the polyethylene glycol is 0.48: 1
The preparation method of the medical water-soluble lubricant is the same as that of example 1.
Example 7
Embodiment 7 of the present invention provides a medical water-soluble lubricant, comprising the following preparation raw materials, by weight, 27 parts of polyethylene glycol, 6.2 parts of hyaluronic acid, 3.5 parts of carbomer, 16.6 parts of small-molecule polyol, a pH regulator, and 88 parts of purified water;
the carbomer comprises carbomer 941, carbomer 980 and carbomer AQUA SF-1, wherein the weight ratio of the carbomer 941 to the carbomer 980 to the carbomer AQUA SF-1 is 1: 0.47: 0.26;
the polyethylene glycol comprises PEG-400 and PEG-1500, wherein the weight ratio of the PEG-400 to the PEG-1500 is 1: 0.33;
the small molecular polyol is glycerol; the pH regulator is sodium hydroxide;
the preparation raw materials also comprise amine compounds, wherein the amine compounds are hydroxypropyl trimethyl ammonium chloride chitosan and are purchased from Shandong Fengtai BioLimited science and technology company; the weight ratio of the amine compound to the polyethylene glycol is 0.48: 1
The preparation method of the medical water-soluble lubricant is the same as that of example 1.
Example 8
The embodiment 8 of the invention provides a medical water-soluble lubricant, which comprises the following preparation raw materials, by weight, 27 parts of polyethylene glycol, 6.2 parts of hyaluronic acid, 3.5 parts of carbomer, 16.6 parts of small-molecular polyol, a pH regulator and 88 parts of purified water;
the carbomer comprises carbomer 941, carbomer 980 and carbomer AQUA SF-1, wherein the weight ratio of the carbomer 941 to the carbomer 980 to the carbomer AQUA SF-1 is 1: 0.47: 0.26;
the polyethylene glycol comprises PEG-400;
the small molecular polyol is glycerol; the pH regulator is sodium hydroxide;
the preparation raw materials also comprise amine compounds, wherein the amine compounds are hydroxypropyl trimethyl ammonium chloride chitosan and are purchased from Shandong Fengtai BioLimited science and technology company; the weight ratio of the amine compound to the polyethylene glycol is 0.48: 1
The preparation method of the medical water-soluble lubricant is the same as that of example 1.
Example 9
Embodiment 9 of the present invention provides a medical water-soluble lubricant, comprising the following preparation raw materials, by weight, 27 parts of polyethylene glycol, 6.2 parts of hyaluronic acid, 3.5 parts of carbomer, 16.6 parts of small-molecule polyol, a pH regulator, and 88 parts of purified water;
the carbomer comprises carbomer 941, carbomer 980 and carbomer AQUA SF-1, wherein the weight ratio of the carbomer 941 to the carbomer 980 to the carbomer AQUA SF-1 is 1: 0.47: 0.26;
the polyethylene glycol comprises PEG-400, PEG-1500 and PEG-4000, and the weight ratio of the PEG-400 to the PEG-1500 to the PEG-4000 is 1: 0.33: 0.45 of;
the small molecular polyol is glycerol; the pH regulator is sodium hydroxide;
the preparation method of the medical water-soluble lubricant is the same as that of example 1.
Performance evaluation
1. Detecting the characters, namely observing whether the products obtained in the examples 1-9 have the undesirable phenomena of flocculation, sedimentation, caking and the like, wherein each example corresponds to 60 samples, and if the undesirable phenomena of flocculation, sedimentation, caking and the like are generated, the number of the undesirable phenomena is 0-3 and is recorded as ◎, the number of the undesirable phenomena is 4-15 and is recorded as ⊙, the number of the undesirable phenomena is 16-30 and is recorded as △, and the redundant 30 is recorded as x;
2. the coating performance characterization comprises the steps of measuring the coating easiness of the products obtained in the examples 1-9, dividing the products into easy coating and difficult coating, wherein each example corresponds to 60 samples, and if the number of the difficult coating is 0-3, the number is recorded as ◎, the number is 4-15, the number is recorded as ⊙, the number is 16-30, the number is recorded as △, and the redundant 30 is recorded as x;
3. storage stability: standing the product obtained in the embodiment 1-9 at 25 ℃ for 30d, and calculating the mass loss W, wherein the calculation formula is as follows: w ═ m0-m1)/m0X 100%, wherein m0Is the mass before standing; m is1Is the mass after standing; when W is<5% as ◎%, 5%<W<15% is ⊙, 15%<W<The 45 percent is recorded as △, and the 45 percent is recorded as<W is marked as X.
TABLE 1
| Traits | Coatability | Storage stability | |
| Example 1 | ◎ | ◎ | ◎ |
| Example 2 | ◎ | ◎ | ◎ |
| Example 3 | ◎ | ◎ | ◎ |
| Example 4 | ⊙ | △ | ⊙ |
| Example 5 | △ | ⊙ | △ |
| Example 6 | ⊙ | △ | ⊙ |
| Example 7 | ⊙ | ⊙ | ⊙ |
| Example 8 | △ | △ | × |
| Example 9 | △ | ⊙ | △ |
Claims (10)
1. The medical water-soluble lubricant is characterized in that the preparation raw materials comprise polyethylene glycol, hyaluronic acid, carbomer, micromolecular polyalcohol, a pH regulator and purified water.
2. The water-soluble lubricant for medical use according to claim 1, wherein the raw materials comprise, by weight, 20-35 parts of polyethylene glycol, 3-8 parts of hyaluronic acid, 1-5 parts of carbomer, 12-19 parts of small-molecule polyol, 0.3-1.5 parts of pH regulator, and 75-100 parts of purified water.
3. The water soluble lubricant for medical use according to claim 1 or 2, wherein the carbomer is selected from the group consisting of any one or more of carbomer 940, carbomer 941, carbomer 934, carbomer 91342, carbomer 980, carbomer EDT 2020, carbomer AQUA SF-1, carbomer Ultrez 21, carbomer Ultrez 20.
4. The water-soluble lubricant according to claim 1 or 2, wherein the polyethylene glycol is selected from any one or more of PEG-400, PEG-600, PEG-800, PEG-1000, PEG-1200, PEG-1450, PEG-2000, PEG-4000, PEG-6000, PEG-8000 and PEG-400.
5. The medical water-soluble lubricant according to claim 1 or 2, wherein the small molecular polyol is selected from any one or more of glycerol, ethylene glycol, propylene glycol, butylene glycol, erythritol, xylitol, D-sorbitol, and inositol.
6. The medical water-soluble lubricant according to any one of claims 1 to 5, wherein the preparation raw materials further comprise an amine compound, and the weight ratio of the amine compound to the polyethylene glycol is (0.33-0.65): 1.
7. the water-soluble lubricant for medical use according to any one of claims 1 to 6, wherein the pH of the water-soluble lubricant for medical use is 6.0 to 7.5.
8. The medical water-soluble lubricant according to any one of claims 1 to 6, wherein the viscosity of the medical water-soluble lubricant is more than 12000mpa.s at 25 ℃.
9. A method for preparing the medical water-soluble lubricant according to any one of claims 1 to 8, which comprises the following steps:
(1) blending polyethylene glycol, hyaluronic acid and small molecular polyol;
(2) mixing carbomer with purified water; then stirring and mixing with the substance obtained in the step (1);
(3) and (3) adding a pH regulator into the system obtained in the step (2), stirring and mixing, and sterilizing to obtain the aqueous lubricant.
10. The medical water-soluble lubricant according to any one of claims 1 to 8 is used for detection of gastroscopy and enteroscopy.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010159694.9A CN111298201A (en) | 2020-03-10 | 2020-03-10 | Medical lubricant and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010159694.9A CN111298201A (en) | 2020-03-10 | 2020-03-10 | Medical lubricant and preparation method thereof |
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| Publication Number | Publication Date |
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| CN111298201A true CN111298201A (en) | 2020-06-19 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202010159694.9A Withdrawn CN111298201A (en) | 2020-03-10 | 2020-03-10 | Medical lubricant and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117398530A (en) * | 2023-11-15 | 2024-01-16 | 上海科进医疗科技有限公司 | Graphene medical water-soluble lubricant and preparation method thereof |
-
2020
- 2020-03-10 CN CN202010159694.9A patent/CN111298201A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117398530A (en) * | 2023-11-15 | 2024-01-16 | 上海科进医疗科技有限公司 | Graphene medical water-soluble lubricant and preparation method thereof |
| CN117398530B (en) * | 2023-11-15 | 2024-03-26 | 上海科进医疗科技有限公司 | Graphene medical water-soluble lubricant and preparation method thereof |
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Application publication date: 20200619 |