CN111298054A - 一种含柞树成分的资料妇科炎症的洗液及其制备方法 - Google Patents
一种含柞树成分的资料妇科炎症的洗液及其制备方法 Download PDFInfo
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- CN111298054A CN111298054A CN201811515410.4A CN201811515410A CN111298054A CN 111298054 A CN111298054 A CN 111298054A CN 201811515410 A CN201811515410 A CN 201811515410A CN 111298054 A CN111298054 A CN 111298054A
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Abstract
本发明的含柞树成分的资料妇科炎症的洗液使用柞树和益母草、败酱草、蒲公英，延胡索，菝葜、玉米须、薄荷、丁香、柴胡、防风和炙甘草为原料，通过将上述的原料的配伍与提取，最大程度的发挥组合物有效成分，使洗液的渗透力加强，能有效渗透到病灶，对外阴疾病、阴道疾病、子宫疾病等妇科炎症有很好的预防和治疗效果；本发明的洗液使用的原料纯天然，无毒副作用，更加安全，使用放心。本发明公开的含柞树成分的资料妇科炎症的洗液含有的柞树，针对各个原料的特性进行提取，能有效分离各组分的有效成分，将部分中药制备成精油，增加洗液中的有效成分的挥发和渗透作用，使各个成分的有效成分结合后，发挥更好的药效，使预防和治疗效果达到最佳。
Description
技术领域
本发明属于医药领域，具体地，涉及一种含柞树成分的资料妇科炎症的洗液及其制备方法。
背景技术
妇科炎症是女性的常见疾病，主要是指女性生殖器官的炎症(外阴炎、阴道炎、宫颈炎、子宫炎、盆腔炎、附件炎、性传播疾病等)，女性的生殖器官通常发生不同的急性和慢性炎症，在受到各种致病菌侵袭感染后发生的炎症。炎症不及时预防和治疗，除可能导致炎症在各生理部位相互蔓延和交叉感染外，会带来许多并发症，对免疫功能、新陈代谢以及内分泌系统都会产生不良影响，甚至导致某些部位的恶性病变。若是妊娠女性，可引起宫内感染、产道感染等影响新生儿，造成流产、早产、先天发育畸形、智力低下等严重后果。
一般日常护理即使用中药洗液或西药作用；西药的作用较快，但毒副作用较大，大多中药洗液只是清除局部病菌，一般都是只是作用于阴部表面，不能彻底消灭细菌达到治愈炎症的效果。
因此，发明一种能具有一定渗透作用，能彻底治疗妇科疾病的洗液是非常必要的。
发明内容
本发明针对上述问题，提供一种含柞树成分的资料妇科炎症的洗液。本发明的含柞树成分的资料妇科炎症的洗液使用柞树和益母草、败酱草、蒲公英，延胡索，菝葜、玉米须、薄荷、丁香、柴胡、防风和炙甘草为原料，通过将上述的原料的配伍与提取，最大程度的发挥组合物有效成分，使洗液的渗透力加强，能有效渗透到病灶，对外阴疾病、阴道疾病、子宫疾病等妇科炎症有很好的预防和治疗效果；本发明的洗液使用的原料纯天然，无毒副作用，更加安全，使用放心。
本发明的含柞树成分的资料妇科炎症的洗液的各种成分组合使得女性身体内环境处于稳态平和，有效预防和治疗阴道炎。
本发明是通过以下技术方案实现的：
公开的含柞树成分的资料妇科炎症的洗液，制成所述洗液有效成分的原料组成及重量份数为：柞树15～25份、益母草3～6份、败酱草1～3份、蒲公英2～5份，延胡索2～5份，菝葜8～12份、玉米须3～6份、薄荷5～8份、丁香8～10份、柴胡3～8份、防风1～3份、炙甘草2～4份。
本发明的含柞树成分的资料妇科炎症的洗液的制备方法，包括以下步骤：
S1.柞树提取物的处理：将柞树的植物碎片加热至炭化，排出的气体经冷凝回收，静置2～3个月，取中层液体蒸馏，取105～110℃馏分的蒸馏液，滤纸过滤，取滤液一；
S2.采用蒸馏法，分别将益母草、薄荷、蒲公英和丁香进行蒸馏，制备出相应的粗制精油；
S3.将所述的益母草、薄荷、蒲公英和丁香的粗制精油分别进行二氧化碳超临界萃取一，得到纯度更高的二级精油；
S4.将败酱草，延胡索，菝葜、玉米须、柴胡、防风和炙甘草在30～40℃下进行水解，经超声波处理后，进行蒸馏处理回收初步提取液；
S5.再将初步提取液进行二氧化碳超临界萃取二，过滤，得到滤液二；
S6.将滤液二用乙醚萃取多次，收集乙醚萃取液，再加入无水硫酸钠干燥后，在50～75℃的水浴中回收乙醚，得到浓缩液；
S7.将滤液一、二级精油和浓缩液用超声波震荡混合均匀，放置在灭菌箱内灭菌处理20～25分钟。
进一步地，步骤S1所述蒸馏液经活性炭吸附4～6小时，滤纸过滤3～6次。
进一步地，步骤S2所述的益母草、薄荷、蒲公英、薄荷和丁香的总质量与蒸馏水的质量比为1:20～25。
进一步地，步骤S3所述二氧化碳超临界萃取一的萃取压力20～40MPa，温度60～80℃，CO2流量2～5L/h，萃取时间100～120min。
进一步地，步骤S4所述超声波处理的频率为40～60KHz，功率为210～350W，微波提取5min～10min。
进一步地，所述二氧化碳超临界萃取二的萃取压力20～40MPa，温度
60～80℃，CO2流量2～5L/h，萃取时间100～120min。
进一步地，步骤S7所述超声波震荡采用频率为30～50MHz，处理5～10min。
本发明的柞树提取物治疗金黄色葡萄球菌或铜绿假单胞菌引起的人表皮炎症性、或感染性、或化脓性疾病具有一定的疗效。
益母草味辛苦、凉，活血、祛淤、调经、消水，治疗妇女月经不调，胎漏难产，胞衣不下，产后血晕，瘀血腹痛，崩中漏下，尿血、泻血，痈肿疮疡。败酱草清热解毒，祛瘀排脓。蒲公英清热解毒，利尿散结。治急性乳腺炎，淋巴腺炎，瘰疬，疔毒疮肿，急性结膜炎，感冒发热，急性扁桃体炎，急性支气管炎，胃炎，肝炎，胆囊炎，尿路感染。延胡索：活血行气，调经止痛，主治妇人使气与血并，心腹作痛，或连腰胁，上下攻刺，经候不调，一切血气疼痛。菝葜有抗炎、镇痛、抗肿瘤、抗氧化、免疫抑制等多种生物活性。玉米须可以提高身体对致敏原的耐受度。薄荷可缓解腹痛、胆囊问题如痉挛，还具有防腐杀菌的作用。丁香对葡萄球菌、链球菌、大肠杆菌、伤寒杆菌、绿脓杆菌等有抑制作用。柴胡具有祛除寒邪之气、下气消食、润心肺、益气力、润肤、益精的功效，能治疗阳气下陷、月经不调、健忘等症。防风具有祛风解表，胜湿止痛，止痉的功效。含炙甘草有甘草素，它有助于平衡女性体内的激素含量。
相比现有技术，本发明的含柞树成分的资料妇科炎症的洗液，具有以下优势：
本发明的含柞树成分的资料妇科炎症的洗液使用柞树和益母草、败酱草、蒲公英，延胡索，菝葜、玉米须、薄荷、丁香、柴胡、防风和炙甘草为原料，通过将上述的原料的配伍与提取，最大程度的发挥组合物有效成分，使洗液的渗透力加强，能有效渗透到病灶，对外阴疾病、阴道疾病、子宫疾病等妇科炎症有很好的预防和治疗效果；本发明的洗液使用的原料纯天然，无毒副作用，更加安全，使用放心。
本发明公开的含柞树成分的资料妇科炎症的洗液含有的柞树，针对各个原料的特性进行提取，能有效分离各组分的有效成分，将部分中药制备成精油，增加洗液中的有效成分的挥发和渗透作用，使各个成分的有效成分结合后，发挥更好的药效，使预防和治疗效果达到最佳。
本发明公开的含柞树成分的资料妇科炎症的洗液的中药组成物工艺制备过程简单，在反应过程中不会对环境产生任何有害物质，操作方便，且能耗低、污染少。
具体实施方式
下面结合具体实施例进一步说明本发明。除非特别说明，本发明实施例中采用的原料和方法为本领域常规市购的原料和常规使用的方法，所使用的设备为本领域常规设备。
本发明提供的含柞树成分的资料妇科炎症的洗液，制成所述洗液有效成分的原料组成及重量份数为：柞树15～25份、益母草3～6份、败酱草1～3份、蒲公英2～5份，延胡索2～5份，菝葜8～12份、玉米须3～6份、薄荷5～8份、丁香8～10份、柴胡3～8份、防风1～3份、炙甘草2～4份。
实施例1
本实施例提供的含柞树成分的资料妇科炎症的洗液，制成的洗液有效成分的原料组成及重量份数为：柞树18份、益母草6份、败酱草1份、蒲公英5份，延胡索2份，菝葜8份、玉米须6份、薄荷5份、丁香10份、柴胡3份、防风3份、炙甘草4份。
具体制备包括以下步骤：
S1.柞树提取物的处理：将柞树的植物碎片加热至炭化，排出的气体经冷凝回收，静置2～3个月，取中层液体蒸馏，取105～110℃馏分的蒸馏液，活性炭吸附4～6小时，滤纸过滤3～6次，取滤液一；
S2.采用蒸馏法，分别将益母草、薄荷、蒲公英、薄荷和丁香进行蒸馏，益母草、薄荷、蒲公英和丁香的总质量与蒸馏水的质量比为1:25，制备出相应的粗制精油；
S3.将益母草、薄荷、蒲公英和丁香的粗制精油分别进行二氧化碳超临界萃取一，萃取压力20MPa，温度80℃，CO2流量5L/h，萃取时间100min；得到纯度更高的二级精油；
S4.将败酱草，延胡索，菝葜、玉米须、柴胡、防风和炙甘草在30～40℃下进行水解，具体为将本步骤的中药材加入足量水进行浸泡，浸泡时同时加入麦芽糖和糖苷合成酶，浸泡后的中药材经过煎煮法得到水溶液；水溶液冷却后加入糖苷水解酶(纤维素酶和果胶酶)在30～40℃进行水解反应得到水解溶液；经超声波处理后，进行蒸馏处理回收初步提取液；超声波处理的频率为40KHz，功率为350W，处理5min；
S5.再将初步提取液进行二氧化碳超临界萃取二，萃取压力20MPa，温度60℃，CO2流量5L/h，萃取时间100min，过滤，得到滤液二；
S6.将滤液二用乙醚萃取多次，收集乙醚萃取液，再加入无水硫酸钠干燥后，在50～75℃的水浴中回收乙醚，得到浓缩液；
S7.将滤液一、二级精油和浓缩液用超声波震荡混合均匀，超声波震荡采用频率为30MHz，处理10min；放置在灭菌箱内灭菌处理20分钟。
实施例2
本实施例提供的含柞树成分的资料妇科炎症的洗液，制成的洗液有效成分的原料组成及重量份数为：柞树25份、益母草3份、败酱草3份、蒲公英2份，延胡索5份，菝葜12份、玉米须3份、薄荷8份、丁香8份、柴胡8份、防风1份、炙甘草2份。
具体制备包括以下步骤：
S1.柞树提取物的处理：将柞树的植物碎片加热至炭化，排出的气体经冷凝回收，静置2～3个月，取中层液体蒸馏，取105～110℃馏分的蒸馏液，活性炭吸附4～6小时，滤纸过滤3～6次，取滤液一；
S2.采用蒸馏法，分别将益母草、薄荷、蒲公英、薄荷和丁香进行蒸馏，益母草、薄荷、蒲公英和丁香的总质量与蒸馏水的质量比为1:20，制备出相应的粗制精油；
S3.将益母草、薄荷、蒲公英和丁香的粗制精油分别进行二氧化碳超临界萃取一，萃取压力40MPa，温度60℃，CO2流量2L/h，萃取时间120min；得到纯度更高的二级精油；
S4.将败酱草，延胡索，菝葜、玉米须、柴胡、防风和炙甘草在30～40℃下进行水解，具体为将本步骤的中药材加入足量水进行浸泡，浸泡时同时加入麦芽糖和糖苷合成酶，浸泡后的中药材经过煎煮法得到水溶液；水溶液冷却后加入糖苷水解酶(纤维素酶和果胶酶)在30～40℃进行水解反应得到水解溶液；经超声波处理后，进行蒸馏处理回收初步提取液；超声波处理的频率为60KHz，功率为210W，处理10min；
S5.再将初步提取液进行二氧化碳超临界萃取二，萃取压力20MPa，温度60℃，CO2流量5L/h，萃取时间100min，过滤，得到滤液二；
S6.将滤液二用乙醚萃取多次，收集乙醚萃取液，再加入无水硫酸钠干燥后，在50～75℃的水浴中回收乙醚，得到浓缩液；
S7.将滤液一、二级精油和浓缩液用超声波震荡混合均匀，超声波震荡采用频率为50MHz，处理5min；放置在灭菌箱内灭菌处理25分钟。
实施例3
本实施例提供的含柞树成分的资料妇科炎症的洗液，制成的洗液有效成分的原料组成及重量份数为：柞树15份、益母草4份、败酱草2份、蒲公英4份，延胡索3份，菝葜10份、玉米须5份、薄荷6份、丁香8份、柴胡8份、防风1份、炙甘草3份。
具体制备方法基本与实施例1相同，其不同之处在于S3将益母草、薄荷、蒲公英和丁香的粗制精油分别进行二氧化碳超临界萃取一，萃取压力30MPa，温度70℃，CO2流量3L/h，萃取时间110min；得到纯度更高的二级精油；其余步骤与实施例1相同。
对比例1
本对比例提供的含柞树成分的资料妇科炎症的洗液，制成所述洗液有效成分的原料组成及重量份数为：柞树10份、益母草4份、败酱草2份、蒲公英4份，延胡索3份，菝葜10份、玉米须5份、薄荷6份、丁香8份、柴胡8份、防风1份、炙甘草3份。具体操作步骤与实施例1相同。
对比例2
本对比例提供的含柞树成分的资料妇科炎症的洗液，制成所述洗液有效成分的原料组成及重量份数为：柞树30份、益母草4份、败酱草2份、蒲公英4份，延胡索3份，菝葜10份、玉米须5份、薄荷6份、丁香8份、柴胡8份、防风1份、炙甘草3份。具体操作步骤与实施例1相同。
对比例3
本对比例提供的含柞树成分的资料妇科炎症的洗液，制成所述洗液有效成分的原料组成及重量份数为：益母草6份、败酱草1份、蒲公英5份，延胡索2份，菝葜8份、玉米须6份、薄荷5份、丁香10份、柴胡3份、防风3份、炙甘草4份。即其原料中不添加柞树，具体操作步骤与实施例1基本相同，去除关于柞树提取制备的步骤。
对比例4
本对比例提供的含柞树成分的资料妇科炎症的洗液，制成的洗液有效成分的原料组成及重量份数为：柞树18份、益母草6份、败酱草1份、蒲公英5份，延胡索2份，菝葜8份、玉米须6份、薄荷5份、丁香10份、柴胡3份、防风3份、炙甘草4份。其制备方法去除原步骤S2和S3，将所有的中药在30～40℃进行水解，超声蒸馏提取，其余制备方法一实施例1相同。
将实施例1～实施例3的含柞树成分的资料妇科炎症的洗液通过以下临床试验验证本发明的有益效果：1、临床资料：挑选100位女性病例的年龄为30～52岁，其中女性均具有不同程度的带下量多，黄白相间或黄色，外阴不适或瘙痒、疼痛。西医诊断为外阴炎，阴道炎、宫颈炎、盆腔炎、附件炎、子宫内膜炎。中医辨证属湿热蕴结或兼脾虚湿注型。
2、诊断标准：1.小腹疼痛或少腹一侧或两侧疼痛；2.带下量多，色黄或白，呈脓性、水样，或携血丝，有臭秽气；3.腰骶酸痛；4.神疲肢软；5.阴痒或有痛感。
3、治疗方法：将洗液每周1～2次洗外阴部，三个月为一个疗程，共治疗2个疗程。
4、疗效评价：
痊愈：诊断标准中的所有项的所有症状均有明显改善，并通过医生检查诊断无外阴炎，阴道炎、宫颈炎、盆腔炎、附件炎、子宫内膜炎等病症。
好转：诊断标准中的所有项的所有症状均有改善，并通过医生检查诊断外阴炎，阴道炎、宫颈炎、盆腔炎、附件炎、子宫内膜炎等病症较使用本发明的安全套前均有改善或好转。
无效：诊断标准中的所有项的所有症状均无改善，并通过医生检查诊断外阴炎，阴道炎、宫颈炎、盆腔炎、附件炎、子宫内膜炎等病症较使用本发明的安全套前均无改善或好转。
5、治疗效果见下表1
表1
| 治愈 | 有效 | 无效 | 有效率 | |
| 女性评价 | 21 | 74 | 5 | 95％ |
本发明通过上述实施例来说明本发明的详细工艺设备和工艺步骤，本领域技术人员应该了解，本发明不受上述实施例限制，上述实施例和说明书中描述的只是说明本发明的原理，在不脱离本发明精神和范围的前提下，本发明还会有各种变化和改进，这对本领域技术人员而言是显而易见的，这些变化和改进都落入要求保护的本发明范围内。
Claims (8)
1.一种含柞树成分的资料妇科炎症的洗液，其特征在于：制成所述洗液有效成分的原料组成及重量份数为：柞树15～25份、益母草3～6份、败酱草1～3份、蒲公英2～5份，延胡索2～5份，菝葜8～12份、玉米须3～6份、薄荷5～8份、丁香8～10份、柴胡3～8份、防风1～3份、炙甘草2～4份。
2.一种根据权利要求1所述含柞树成分的资料妇科炎症的洗液的制备方法，其特征在于，包括以下步骤：
S1.柞树提取物的处理：将柞树的植物碎片加热至炭化，排出的气体经冷凝回收，静置2～3个月，取中层液体蒸馏，取105～110℃馏分的蒸馏液，滤纸过滤，取滤液一；
S2.采用蒸馏法，分别将益母草、薄荷、蒲公英和丁香进行蒸馏，制备出相应的粗制精油；
S3.将所述的益母草、薄荷、蒲公英和丁香的粗制精油分别进行二氧化碳超临界萃取一，得到纯度更高的二级精油；
S4.将败酱草，延胡索，菝葜、玉米须、柴胡、防风和炙甘草在30～40℃下进行水解，经超声波处理后，进行蒸馏处理回收初步提取液；
S5.再将初步提取液进行二氧化碳超临界萃取二，过滤，得到滤液二；
S6.将滤液二用乙醚萃取多次，收集乙醚萃取液，再加入无水硫酸钠干燥后，在50～75℃的水浴中回收乙醚，得到浓缩液；
S7.将滤液一、二级精油和浓缩液用超声波震荡混合均匀，放置在灭菌箱内灭菌处理20～25分钟。
3.根据权利要求2所述含柞树成分的资料妇科炎症的洗液，其特征在于，步骤S1所述蒸馏液经活性炭吸附4～6小时，滤纸过滤3～6次。
4.根据权利要求2所述含柞树成分的资料妇科炎症的洗液，其特征在于，步骤S2所述的益母草、薄荷、蒲公英、薄荷和丁香的总质量与蒸馏水的质量比为1:20～25。
5.根据权利要求2所述含柞树成分的资料妇科炎症的洗液，其特征在于，步骤S3所述二氧化碳超临界萃取一的萃取压力20～40MPa，温度60～80℃，CO2流量2～5L/h，萃取时间100～120min。
6.根据权利要求2所述含柞树成分的资料妇科炎症的洗液，其特征在于，步骤S4所述超声波处理的频率为40～60KHz，功率为210～350W，处理5min～10min。
7.根据权利要求2所述含柞树成分的资料妇科炎症的洗液，其特征在于，步骤S5所述二氧化碳超临界萃取二的萃取压力20～40MPa，温度60～80℃，CO2流量2～5L/h，萃取时间100～120min。
8.根据权利要求2所述含柞树成分的资料妇科炎症的洗液，其特征在于，步骤S7所述超声波震荡采用频率为30～50MHz，处理5～10min。
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