CN111286235A - Preparation method of glass medical instrument surface coating - Google Patents

Preparation method of glass medical instrument surface coating Download PDF

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CN111286235A
CN111286235A CN201810842131.2A CN201810842131A CN111286235A CN 111286235 A CN111286235 A CN 111286235A CN 201810842131 A CN201810842131 A CN 201810842131A CN 111286235 A CN111286235 A CN 111286235A
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coating
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陈庆
曾军堂
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Chengdu New Keli Chemical Science Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D133/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Coating compositions based on derivatives of such polymers
    • C09D133/04—Homopolymers or copolymers of esters
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D7/00—Features of coating compositions, not provided for in group C09D5/00; Processes for incorporating ingredients in coating compositions
    • C09D7/40—Additives
    • C09D7/60—Additives non-macromolecular
    • C09D7/61—Additives non-macromolecular inorganic

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Abstract

The invention relates to the field of medical materials, and discloses a preparation method of a glass medical instrument surface coating. The preparation method comprises the following preparation processes: (1) cleaning and drying medical glass medical instruments; (2) adding a biomass polymer, an EVA elastomer emulsion, an emulsifier and ethanol into a solvent, stirring and dispersing to prepare a composite emulsion; (3) adding tetraethoxysilane and hydrochloric acid into the composite emulsion to form nano particles; (4) heating, pressurizing, and drying by a nozzle to obtain the shell-core elastic microspheres; (5) mixing the elastic microspheres with calcium acetate, water-based acrylic resin, a nano material, a film-forming aid and deionized water to obtain a coating; (6) the silicic acid and the paint are sprayed in sequence, and a coating can be formed on the surface of the glass medical instrument. The coating prepared by the invention has the advantages that the obtained elastic microspheres are firmly fixed in the formed calcium silicate, the hydrophilicity and the smoothness of the coating are obviously improved, the hand feeling is flexible, the delamination is avoided, and the service durability is good.

Description

Preparation method of glass medical instrument surface coating
Technical Field
The invention relates to the field of medical materials, and discloses a preparation method of a glass medical instrument surface coating.
Background
Interventional medicine is a low-invasive or minimally invasive technique that has formed one of three major clinical medicine paralleling surgery and medicine, while imaging devices and interventional instruments are the mainstay of interventional medicine. The wonderful point lies in that the diagnosis and treatment range is large, the treatment difficulty is high, and the patients can be deeply invaded into the human body almost without possibility. Can not only turn back the distress that the internal medicine can not help to change the tissue structure, but also avoid the injury of the surgical operation to the organism, has little damage to the human body, and has very reliable and obvious treatment effect. Therefore, interventionalists have become a "new favorite" in today's medical community.
Lubricity is one of the very important properties of interventional devices (catheters, guidewires). For example, various catheters are commonly used in medical treatment for achieving the purpose of replacing and controlling certain functions of a human body. Such as a catheter, a trachea cannula, a central venous catheter, a PICC (peripherally inserted Central catheter), an in-tube sleeve, a ventricular drainage tube, a three-cavity two-sac tube, a closed thoracic drainage tube and the like. While necessary and beneficial for treating various medical conditions, metallic or polymeric devices (e.g., catheters, etc.) can cause a number of physiological complications after placement in the body. Therefore, the surfaces of these instruments are required to have lubricity when inserted or extracted from the human body, so as to reduce the damage and adhesion to the tissues and relieve the pain of the patient.
At present, two ways to solve the problem of lubricity are available, one is to use lubricating oil, but the lubricity obtained by the treatment method is poor, difficult to last and unfavorable for operation. One is to form a hydrophilic coating with lubricity on the surface of the instrument. Because the interventional device moves in the body and stays for a period of time, the hydrophilic coating on the interventional device has both hydrophilic lubricating performance and stability, namely the coating does not fall off after repeated friction, and good comprehensive performance is maintained. Such techniques have been widely used, because they can fix hydrophilic compounds by chemical bond or physical entanglement.
Chinese patent application No. 201810063901.3 discloses a hydrophilic lubricating coating, which comprises the following components in parts by weight: 5-15 parts of acrylamide modified vinyl pyrrolidone polymer; 10-30 parts of waterborne polyurethane; 1-10 parts of a water-based crosslinking agent; 1-5 parts of a leveling agent; 40-83 parts of a solvent. The invention can realize good adhesion with the base material, can form a stable coating on the surface of the base material, has excellent effect of permanently exerting hydrophilic lubrication, and is suitable for popularization and use.
The Chinese patent application No. 201710297442.0 discloses a preparation method of a hydrophilic coating on the surface of a medical instrument, which comprises the following steps: dissolving a hydrophilic high polymer in an organic solvent to obtain a hydrophilic high polymer solution; adding an inorganic composition consisting of inorganic simple substances and water-soluble inorganic salt into a hydrophilic high polymer solution, and fully mixing to obtain an inorganic composition solution; dissolving an anti-hemagglutination medicine in an organic solvent to obtain an anti-hemagglutination solution; adding the anti-blood coagulation solution into the inorganic composition solution and water, and uniformly stirring to obtain a hydrophilic coating composition on the surface of the medical instrument; the hydrophilic coating composition on the surface of the medical instrument is uniformly sprayed on the surface of the stainless steel medical instrument.
According to the above, the medical equipment used for interventional medicine in the existing scheme has the defects of poor biocompatibility, poor flexibility, poor sliding property and the like, at present, the number of hydrophilic ultra-smooth coating products used for the surface of the medical equipment is very small in China, and the products are monopoly abroad.
Disclosure of Invention
The prior widely applied glass medical equipment for interventional medicine has the defects of poor biocompatibility, poor flexibility, poor sliding property and the like, but the technical research on the domestic hydrophilic super-smooth coating is immature, and the number of products is small.
In order to solve the problems, the invention adopts the following technical scheme:
a preparation method of a glass medical instrument surface coating comprises the following specific steps:
(1) firstly, ultrasonically cleaning medical glass medical instruments by using distilled water and a dilute hydrochloric acid solution in sequence, and then drying for later use;
(2) dissolving a biomass polymer in a solvent, adding an EVA elastomer emulsion, an emulsifier and ethanol, stirring and dispersing to disperse the biomass polymer into nanoparticles, and preparing a composite emulsion;
(3) adding tetraethoxysilane into the composite emulsion prepared in the step (2), fully stirring, and then adding hydrochloric acid to form uniformly dispersed nano particles of the water-phase silica sol coated oil-phase biomass polymer;
(4) heating, pressurizing, drying and dispersing by a nozzle to form a silica coated biomass polymer shell-core elastic microsphere, wherein the biomass polymer is an inner core, the silica is an outer layer, and the EVA elastomer is dispersed in the outer layer silica and penetrates through the outer layer to be tightly connected with the inner core;
(5) mixing the elastic microspheres obtained in the step (4) with calcium acetate, water-based acrylic resin, a nano material, a film-forming aid and deionized water, and dispersing into a coating;
(6) spraying silicic acid on the surface of the glass piece, spraying a coating after 3min, wherein calcium ions in the coating and silicate radicals on a glass interface form firm calcium silicate, uniformly adhering the elastic microspheres to the surface of the glass piece under the film forming action of the water-based acrylic resin, and forming a coating with good hydrophilicity, falling resistance and smoothness on the surface of a glass medical instrument.
Preferably, the biomass polymer in the step (2) is one of polylactic acid and polycaprolactone.
Preferably, the solvent in step (2) is one of benzene, toluene, chlorobenzene, styrene, trichloroethylene, perchloroethylene, and ethylene glycol ether.
Preferably, the emulsifier in step (2) is at least one of polyethylene glycol and sodium dodecyl sulfate.
Preferably, in the composite emulsion in the step (2), 20-30 parts by weight of biomass polymer, 47-63 parts by weight of solvent, 12-15 parts by weight of EVA elastomer emulsion, 1-2 parts by weight of emulsifier and 4-6 parts by weight of ethanol are used. The EVA elastomer emulsion has a solid content of 18 wt%.
Preferably, in the raw materials in the step (3), 83-89 parts by weight of the composite emulsion, 8-12 parts by weight of ethyl orthosilicate and 3-5 parts by weight of hydrochloric acid are used.
Preferably, the temperature rise in the step (4) is 130-150 ℃, and the pressurizing pressure is 4-6 bar.
Preferably, the nano material in the step (5) is at least one of nano zinc oxide, nano titanium dioxide, nano calcium carbonate, nano tin dioxide and nano talcum powder.
Preferably, the film forming aid in the step (5) is one of propylene glycol butyl ether and propylene glycol methyl ether acetate.
Preferably, in the coating in the step (5), 15-30 parts by weight of elastic microspheres, 3-5 parts by weight of calcium acetate, 1.5-2 parts by weight of water-based acrylic resin, 4-8 parts by weight of nano material, 0.5-1 part by weight of film-forming assistant and 54-76 parts by weight of deionized water.
The method for preparing the surface coating of the glass medical instrument mainly comprises the steps of sequentially ultrasonically cleaning the medical glass medical instrument by using distilled water and a dilute hydrochloric acid solution, and drying for later use; dissolving a biomass polymer in a solvent, adding an EVA elastomer emulsion, an emulsifier and ethanol, and dispersing to obtain an emulsion, wherein the biomass polymer is dispersed in the emulsion to obtain nano particles; further adding tetraethoxysilane, fully stirring, and adding hydrochloric acid to form uniformly dispersed biomass polymer nanoparticles with the oil phase coated by the water-phase silica sol; heating, pressurizing, drying and dispersing by a nozzle to form the silica-coated biomass polymer shell-core elastic microspheres; the biomass polymer is arranged in the inner core, the silicon dioxide is arranged on the outer layer, the EVA has amphipathy, and the formed elastomer is dispersed in the silicon dioxide on the outer layer and penetrates through the outer layer to be tightly connected with the inner core, so that the shell-core structure is firm; mixing and dispersing the obtained elastic microspheres with calcium acetate, water-based acrylic resin, a nano material, a film-forming aid and deionized water to obtain a coating; spraying silicic acid on the surface of the glass piece, and spraying a coating after 3 min; calcium ions in the coating and silicate groups on a glass interface form firm calcium silicate, the elastic microspheres are uniformly adhered to the surface of a glass piece under the film forming effect of the water-based acrylic resin, and a coating with good hydrophilicity, falling resistance and smoothness is formed on the surface of a glass medical instrument.
The invention discloses a method for forming a good hydrophilic, anti-falling and smooth coating on the surface of a glass medical apparatus, and the specific coating thickness can be selected according to specific requirements. In practice, a preferred coating thickness is 30-50 μm.
The water absorption rate, the friction coefficient and the surface quality wear rate of the surface coating of the glass medical apparatus prepared by the method are shown in the table 1, and compared with the method of directly coating lubricating oil and a common PVD coating, the method has obvious advantages, as shown in the table 1.
Table 1:
performance index The invention Lubricating oil PVD coating
Water absorption (%) 4~5 1~2 3~4
Coefficient of friction 0.05~0.15 0.1~0.2 0.2~0.4
Skin surface quality wear rate (%) 0.1~0.2 2~5 0.5~1.5
Hand feeling Flexible hand feeling Poor hand feeling flexibility Poor hand feeling flexibility
The invention provides a preparation method of a glass medical instrument surface coating, which has the outstanding characteristics and excellent effects compared with the prior art:
1. a method for preparing a glass medical appliance surface coating by coating silicon dioxide on the surface of a biomass polymer is provided.
2. The silicon dioxide is coated on the surface of the biomass polymer, and the characteristics of the amphipathy of the EVA elastomer emulsion are utilized to penetrate through the outer layer and be tightly connected with the inner core, so that the elastic microspheres are obtained, the hand feeling of the coating is improved, and the coating has better flexibility.
3. The characteristic of the interface of the water glass slightly soluble glass is utilized, calcium ions are dispersed in the coating, and simultaneously, the elastic microspheres are firmly fixed on the surface of the glass medical instrument by utilizing the effect of calcium silicate formed by the water glass and the calcium ions, so that a firm coating is formed, and the coating has good hydrophilicity and smoothness, is not delaminated and has good use durability.
Detailed Description
The present invention will be described in further detail with reference to specific embodiments, but it should not be construed that the scope of the present invention is limited to the following examples. Various substitutions and alterations can be made by those skilled in the art and by conventional means without departing from the spirit of the method of the invention described above.
Example 1
(1) Firstly, ultrasonically cleaning medical glass medical instruments by using distilled water and a dilute hydrochloric acid solution in sequence, and then drying for later use;
(2) dissolving a biomass polymer in a solvent, adding an EVA elastomer emulsion, an emulsifier and ethanol, stirring and dispersing to disperse the biomass polymer into nanoparticles, and preparing a composite emulsion; the biomass polymer is polylactic acid; the solvent is benzene; the emulsifier is polyethylene glycol; in the composite emulsion, 26 parts by weight of biomass polymer, 55 parts by weight of solvent, 13 parts by weight of EVA elastomer emulsion, 1 part by weight of emulsifier and 5 parts by weight of ethanol; the EVA elastomer emulsion has a solid content of 18 wt%.
(3) Adding tetraethoxysilane into the composite emulsion prepared in the step (2), fully stirring, and then adding hydrochloric acid to form uniformly dispersed nano particles of the water-phase silica sol coated oil-phase biomass polymer; in the raw materials, 87 parts by weight of composite emulsion, 9 parts by weight of ethyl orthosilicate and 4 parts by weight of hydrochloric acid;
(4) heating, pressurizing, and drying and dispersing by a nozzle to form the silica-coated biomass polymer shell-core elastic microspheres; the temperature rise is 142 ℃, and the pressure is 5 bar;
(5) mixing the elastic microspheres obtained in the step (4) with calcium acetate, water-based acrylic resin, a nano material, a film-forming aid and deionized water, and dispersing into a coating; the nano material is nano zinc oxide; the film-forming auxiliary agent is propylene glycol butyl ether; in the coating, 21 parts by weight of elastic microspheres, 4 parts by weight of calcium acetate, 1.5 parts by weight of water-based acrylic resin, 5 parts by weight of nano material, 0.5 part by weight of film-forming assistant and 68 parts by weight of deionized water;
(6) spraying silicic acid on the surface of the glass piece, and spraying a coating after 3min to form a coating with good hydrophilicity, falling resistance and smoothness on the surface of the glass medical instrument.
The water absorption, friction coefficient and surface quality wear rate of the surface coating of the glass medical device prepared in example 1 are shown in table 2.
Example 2
(1) Firstly, ultrasonically cleaning medical glass medical instruments by using distilled water and a dilute hydrochloric acid solution in sequence, and then drying for later use;
(2) dissolving a biomass polymer in a solvent, adding an EVA elastomer emulsion, an emulsifier and ethanol, stirring and dispersing to disperse the biomass polymer into nanoparticles, and preparing a composite emulsion; the biomass polymer is polycaprolactone; the solvent is toluene; the emulsifier is sodium dodecyl sulfate; in the composite emulsion, 20 parts by weight of biomass polymer, 63 parts by weight of solvent, 12 parts by weight of EVA elastomer emulsion, 1 part by weight of emulsifier and 4 parts by weight of ethanol; the EVA elastomer emulsion has a solid content of 18 wt%.
(3) Adding tetraethoxysilane into the composite emulsion prepared in the step (2), fully stirring, and then adding hydrochloric acid to form uniformly dispersed nano particles of the water-phase silica sol coated oil-phase biomass polymer; in the raw materials, 89 parts by weight of composite emulsion, 8 parts by weight of ethyl orthosilicate and 3 parts by weight of hydrochloric acid;
(4) heating, pressurizing, and drying and dispersing by a nozzle to form the silica-coated biomass polymer shell-core elastic microspheres; the temperature rise is 130 ℃, and the pressure is 4 bar;
(5) mixing the elastic microspheres obtained in the step (4) with calcium acetate, water-based acrylic resin, a nano material, a film-forming aid and deionized water, and dispersing into a coating; the nano material is nano titanium dioxide; the film-forming auxiliary agent is propylene glycol methyl ether acetate; in the coating, 15 parts by weight of elastic microspheres, 3 parts by weight of calcium acetate, 1.5 parts by weight of water-based acrylic resin, 4 parts by weight of nano material, 0.5 part by weight of film-forming assistant and 76 parts by weight of deionized water;
(6) spraying silicic acid on the surface of the glass piece, and spraying a coating after 3min to form a coating with good hydrophilicity, falling resistance and smoothness on the surface of the glass medical instrument.
The water absorption, friction coefficient and surface quality wear rate of the surface coating of the glass medical device prepared in example 2 are shown in table 2.
Example 3
(1) Firstly, ultrasonically cleaning medical glass medical instruments by using distilled water and a dilute hydrochloric acid solution in sequence, and then drying for later use;
(2) dissolving a biomass polymer in a solvent, adding an EVA elastomer emulsion, an emulsifier and ethanol, stirring and dispersing to disperse the biomass polymer into nanoparticles, and preparing a composite emulsion; the biomass polymer is polylactic acid; the solvent is chlorobenzene; the emulsifier is polyethylene glycol; in the composite emulsion, 22 parts by weight of biomass polymer, 459 parts by weight of solvent, 13 parts by weight of EVA elastomer emulsion, 1 part by weight of emulsifier and 5 parts by weight of ethanol; the EVA elastomer emulsion has a solid content of 18 wt%.
(3) Adding tetraethoxysilane into the composite emulsion prepared in the step (2), fully stirring, and then adding hydrochloric acid to form uniformly dispersed nano particles of the water-phase silica sol coated oil-phase biomass polymer; in the raw materials, 87 parts by weight of composite emulsion, 9 parts by weight of ethyl orthosilicate and 4 parts by weight of hydrochloric acid;
(4) heating, pressurizing, and drying and dispersing by a nozzle to form the silica-coated biomass polymer shell-core elastic microspheres; the temperature rise is 135 ℃, and the pressure is 4.5 bar;
(5) mixing the elastic microspheres obtained in the step (4) with calcium acetate, water-based acrylic resin, a nano material, a film-forming aid and deionized water, and dispersing into a coating; the nano material is nano calcium carbonate; the film-forming auxiliary agent is propylene glycol butyl ether; in the coating, 18 parts by weight of elastic microspheres, 4 parts by weight of calcium acetate, 1.5 parts by weight of water-based acrylic resin, 5 parts by weight of nano material, 0.5 part by weight of film-forming assistant and 71 parts by weight of deionized water;
(6) spraying silicic acid on the surface of the glass piece, and spraying a coating after 3min to form a coating with good hydrophilicity, falling resistance and smoothness on the surface of the glass medical instrument.
The water absorption, friction coefficient and surface quality wear rate of the surface coating of the glass medical device prepared in example 3 are shown in table 2.
Example 4
(1) Firstly, ultrasonically cleaning medical glass medical instruments by using distilled water and a dilute hydrochloric acid solution in sequence, and then drying for later use;
(2) dissolving a biomass polymer in a solvent, adding an EVA elastomer emulsion, an emulsifier and ethanol, stirring and dispersing to disperse the biomass polymer into nanoparticles, and preparing a composite emulsion; the biomass polymer is polycaprolactone; the solvent is trichloroethylene; the emulsifier is sodium dodecyl sulfate; in the composite emulsion, 27 parts by weight of biomass polymer, 52 parts by weight of solvent, 14 parts by weight of EVA elastomer emulsion, 2 parts by weight of emulsifier and 5 parts by weight of ethanol; the EVA elastomer emulsion has a solid content of 18 wt%.
(3) Adding tetraethoxysilane into the composite emulsion prepared in the step (2), fully stirring, and then adding hydrochloric acid to form uniformly dispersed nano particles of the water-phase silica sol coated oil-phase biomass polymer; in the raw materials, 84 parts by weight of composite emulsion, 11 parts by weight of ethyl orthosilicate and 3 parts by weight of hydrochloric acid;
(4) heating, pressurizing, and drying and dispersing by a nozzle to form the silica-coated biomass polymer shell-core elastic microspheres; the temperature is raised to 145 ℃, and the pressure is 5.5 bar;
(5) mixing the elastic microspheres obtained in the step (4) with calcium acetate, water-based acrylic resin, a nano material, a film-forming aid and deionized water, and dispersing into a coating; the nano material is nano tin dioxide; the film-forming auxiliary agent is propylene glycol methyl ether acetate; in the coating, 26 parts by weight of elastic microspheres, 4 parts by weight of calcium acetate, 2 parts by weight of water-based acrylic resin, 7 parts by weight of nano material, 1 part by weight of film-forming assistant and 60 parts by weight of deionized water;
(6) spraying silicic acid on the surface of the glass piece, and spraying a coating after 3min to form a coating with good hydrophilicity, falling resistance and smoothness on the surface of the glass medical instrument.
The water absorption, friction coefficient and surface quality wear rate of the surface coating of the glass medical device prepared in example 4 are shown in table 2.
Example 5
(1) Firstly, ultrasonically cleaning medical glass medical instruments by using distilled water and a dilute hydrochloric acid solution in sequence, and then drying for later use;
(2) dissolving a biomass polymer in a solvent, adding an EVA elastomer emulsion, an emulsifier and ethanol, stirring and dispersing to disperse the biomass polymer into nanoparticles, and preparing a composite emulsion; the biomass polymer is polylactic acid; the solvent is perchloroethylene; the emulsifier is polyethylene glycol; in the composite emulsion, 30 parts by weight of biomass polymer, 47 parts by weight of solvent, 15 parts by weight of EVA elastomer emulsion, 2 parts by weight of emulsifier and 6 parts by weight of ethanol; the EVA elastomer emulsion has a solid content of 18 wt%.
(3) Adding tetraethoxysilane into the composite emulsion prepared in the step (2), fully stirring, and then adding hydrochloric acid to form uniformly dispersed nano particles of the water-phase silica sol coated oil-phase biomass polymer; in the raw materials, 83 parts by weight of composite emulsion, 12 parts by weight of ethyl orthosilicate and 5 parts by weight of hydrochloric acid;
(4) heating, pressurizing, and drying and dispersing by a nozzle to form the silica-coated biomass polymer shell-core elastic microspheres; the temperature rise is 150 ℃, and the pressure is 6 bar;
(5) mixing the elastic microspheres obtained in the step (4) with calcium acetate, water-based acrylic resin, a nano material, a film-forming aid and deionized water, and dispersing into a coating; the nano material is nano talcum powder; the film-forming auxiliary agent is propylene glycol butyl ether; in the coating, 30 parts by weight of elastic microspheres, 5 parts by weight of calcium acetate, 2 parts by weight of water-based acrylic resin, 8 parts by weight of nano material, 1 part by weight of film-forming assistant and 54 parts by weight of deionized water;
(6) spraying silicic acid on the surface of the glass piece, and spraying a coating after 3min to form a coating with good hydrophilicity, falling resistance and smoothness on the surface of the glass medical instrument.
The water absorption, friction coefficient and surface quality wear rate of the surface coating of the glass medical device obtained in example 5 are shown in table 2.
Example 6
(1) Firstly, ultrasonically cleaning medical glass medical instruments by using distilled water and a dilute hydrochloric acid solution in sequence, and then drying for later use;
(2) dissolving a biomass polymer in a solvent, adding an EVA elastomer emulsion, an emulsifier and ethanol, stirring and dispersing to disperse the biomass polymer into nanoparticles, and preparing a composite emulsion; the biomass polymer is polycaprolactone; the solvent is ethylene glycol ether; the emulsifier is sodium dodecyl sulfate; in the composite emulsion, 25 parts by weight of biomass polymer, 55 parts by weight of solvent, 14 parts by weight of EVA elastomer emulsion, 1 part by weight of emulsifier and 5 parts by weight of ethanol;
(3) adding tetraethoxysilane into the composite emulsion prepared in the step (2), fully stirring, and then adding hydrochloric acid to form uniformly dispersed nano particles of the water-phase silica sol coated oil-phase biomass polymer; in the raw materials, 86 parts of composite emulsion, 10 parts of ethyl orthosilicate and 4 parts of hydrochloric acid by weight; the EVA elastomer emulsion has a solid content of 18 wt%.
(4) Heating, pressurizing, and drying and dispersing by a nozzle to form the silica-coated biomass polymer shell-core elastic microspheres; the temperature rise is 140 ℃, and the pressure is 5 bar;
(5) mixing the elastic microspheres obtained in the step (4) with calcium acetate, water-based acrylic resin, a nano material, a film-forming aid and deionized water, and dispersing into a coating; the nano material is nano zinc oxide; the film-forming auxiliary agent is propylene glycol methyl ether acetate; in the coating, 22 parts by weight of elastic microspheres, 4 parts by weight of calcium acetate, 2 parts by weight of water-based acrylic resin, 6 parts by weight of nano material, 1 part by weight of film-forming assistant and 65 parts by weight of deionized water;
(6) spraying silicic acid on the surface of the glass piece, and spraying a coating after 3min to form a coating with good hydrophilicity, falling resistance and smoothness on the surface of the glass medical instrument.
The water absorption, friction coefficient and surface quality wear rate of the surface coating of the glass medical device obtained in example 6 are shown in table 2.
Comparative example 1
Comparative example 1 the water absorption, friction coefficient and surface quality wear rate of the surface coating of the glass medical device prepared without adding the EVA elastomer emulsion are shown in table 2.
The performance index testing method comprises the following steps:
selecting any glass medical instrument as a test piece, and forming a coating on the surface of the test piece according to the method of the invention to prepare a test sample;
firstly weighing a sample, then soaking the sample in distilled water for 9 hours, taking out the sample, then absorbing surface water drops by using filter paper, weighing the sample, and calculating the water absorption rate according to the following formula: p = (G)2-G1）/G1X 100% where G2For mass after water absorption, G1Is an initial mass to characterize the hydrophilicity of the coating;
fixing a sample in a groove corresponding to a GT-7012-HG type static friction tester clamp, placing the sample on a friction panel, soaking the sample in water, setting the speed to be 50mm/min, recording the maximum tension value formed within 100mm, repeating the test for 10 times to obtain an average value, and calculating the friction coefficient according to the following formula: μ = F/W, wherein F is the mean maximum arithmetic number of tensile forces and W is the positive pressure of the sample, and is used for characterizing the lubricity of the coating;
drying the sample, weighing the sample on an analytical balance, dragging the sample on a friction panel for 5m by using a GT-7012-HG type static friction tester, drying the sample in vacuum, and weighing the sample, wherein the surface mass wear rate is calculated according to the following formula: x = (G)n-G0）/G0X 100% where GnThe mass of the sample dried after being dragged over the rubbing panel for 5m, G0The initial quality is used for qualitatively comparing and representing the firmness of the coating;
the coating was felt to be flexible by direct touch with the hand.
Table 2:
performance index Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Comparative example 1
Water absorption (%) 4.3 4.5 4.4 4.6 4.2 4.5 3.2
Coefficient of friction 0.07 0.08 0.09 0.06 0.12 0.08 0.14
Surface quality wear rate (%) 0.14 0.16 0.13 0.15 0.18 0.13 0.24
Hand feeling Flexible hand feeling Flexible hand feeling Flexible hand feeling Flexible hand feeling Flexible hand feeling Flexible hand feeling Poor hand feeling flexibility

Claims (10)

1. A preparation method of a glass medical instrument surface coating is characterized by comprising the following specific steps:
(1) firstly, ultrasonically cleaning medical glass medical instruments by using distilled water and a dilute hydrochloric acid solution in sequence, and then drying for later use;
(2) dissolving a biomass polymer in a solvent, adding an EVA elastomer emulsion, an emulsifier and ethanol, stirring and dispersing to disperse the biomass polymer into nanoparticles, and preparing a composite emulsion;
(3) adding tetraethoxysilane into the composite emulsion prepared in the step (2), fully stirring, and then adding hydrochloric acid to form uniformly dispersed nano particles of the water-phase silica sol coated oil-phase biomass polymer;
(4) heating, pressurizing, drying and dispersing by a nozzle to form a silica coated biomass polymer shell-core elastic microsphere, wherein the biomass polymer is an inner core, the silica is an outer layer, and the EVA elastomer is dispersed in the outer layer silica and penetrates through the outer layer to be tightly connected with the inner core;
(5) mixing the elastic microspheres obtained in the step (4) with calcium acetate, water-based acrylic resin, a nano material, a film-forming aid and deionized water, and dispersing into a coating;
(6) spraying silicic acid on the surface of the glass piece, spraying a coating after 3min, wherein calcium ions in the coating and silicate radicals on a glass interface form firm calcium silicate, uniformly adhering the elastic microspheres to the surface of the glass piece under the film forming action of the water-based acrylic resin, and forming a coating with good hydrophilicity, falling resistance and smoothness on the surface of a glass medical instrument.
2. The method for preparing the glass medical instrument surface coating according to claim 1, wherein the method comprises the following steps: and (3) the biomass polymer in the step (2) is one of polylactic acid and polycaprolactone.
3. The method for preparing the glass medical instrument surface coating according to claim 1, wherein the method comprises the following steps: and (3) the solvent in the step (2) is one of benzene, toluene, chlorobenzene, styrene, trichloroethylene, perchloroethylene and ethylene glycol ether.
4. The method for preparing the glass medical instrument surface coating according to claim 1, wherein the method comprises the following steps: and (3) the emulsifier in the step (2) is at least one of polyethylene glycol and sodium dodecyl sulfate.
5. The method for preparing the glass medical instrument surface coating according to claim 1, wherein the method comprises the following steps: in the composite emulsion in the step (2), 20-30 parts by weight of biomass polymer, 47-63 parts by weight of solvent, 12-15 parts by weight of EVA elastomer emulsion, 1-2 parts by weight of emulsifier and 4-6 parts by weight of ethanol.
6. The method for preparing the glass medical instrument surface coating according to claim 1, wherein the method comprises the following steps: in the raw materials in the step (3), 83-89 parts by weight of composite emulsion, 8-12 parts by weight of ethyl orthosilicate and 3-5 parts by weight of hydrochloric acid.
7. The method for preparing the glass medical instrument surface coating according to claim 1, wherein the method comprises the following steps: and (4) raising the temperature to 130-150 ℃, and pressurizing at 4-6 bar.
8. The method for preparing the glass medical instrument surface coating according to claim 1, wherein the method comprises the following steps: and (5) the nano material is at least one of nano zinc oxide, nano titanium dioxide, nano calcium carbonate, nano tin dioxide and nano talcum powder.
9. The method for preparing the glass medical instrument surface coating according to claim 1, wherein the method comprises the following steps: the film-forming assistant in the step (5) is one of propylene glycol butyl ether and propylene glycol methyl ether acetate.
10. The method for preparing the glass medical instrument surface coating according to claim 1, wherein the method comprises the following steps: in the coating in the step (5), 15-30 parts by weight of elastic microspheres, 3-5 parts by weight of calcium acetate, 1.5-2 parts by weight of water-based acrylic resin, 4-8 parts by weight of nano material, 0.5-1 part by weight of film-forming assistant and 54-76 parts by weight of deionized water.
CN201810842131.2A 2018-07-27 2018-07-27 Preparation method of glass medical instrument surface coating Withdrawn CN111286235A (en)

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