CN114762741A - Surface lubrication anti-adhesion medical pipeline and preparation method thereof - Google Patents
Surface lubrication anti-adhesion medical pipeline and preparation method thereof Download PDFInfo
- Publication number
- CN114762741A CN114762741A CN202110051269.2A CN202110051269A CN114762741A CN 114762741 A CN114762741 A CN 114762741A CN 202110051269 A CN202110051269 A CN 202110051269A CN 114762741 A CN114762741 A CN 114762741A
- Authority
- CN
- China
- Prior art keywords
- medical
- adhesion
- medical pipeline
- pipeline
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000005461 lubrication Methods 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 238000000034 method Methods 0.000 claims abstract description 51
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims abstract description 12
- 238000011282 treatment Methods 0.000 claims description 43
- 238000003682 fluorination reaction Methods 0.000 claims description 32
- 229910052731 fluorine Inorganic materials 0.000 claims description 25
- 239000011737 fluorine Substances 0.000 claims description 24
- 239000000463 material Substances 0.000 claims description 22
- 239000007789 gas Substances 0.000 claims description 21
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 16
- 230000001050 lubricating effect Effects 0.000 claims description 16
- 238000004140 cleaning Methods 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 7
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 6
- 239000008367 deionised water Substances 0.000 claims description 4
- 229910021641 deionized water Inorganic materials 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- 229910052786 argon Inorganic materials 0.000 claims description 3
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 3
- 229910001873 dinitrogen Inorganic materials 0.000 claims description 3
- 239000005038 ethylene vinyl acetate Substances 0.000 claims description 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 3
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims description 3
- -1 polydimethylsiloxane Polymers 0.000 claims description 3
- 229920003225 polyurethane elastomer Polymers 0.000 claims description 3
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 3
- 239000004800 polyvinyl chloride Substances 0.000 claims description 3
- 239000000741 silica gel Substances 0.000 claims description 3
- 229910002027 silica gel Inorganic materials 0.000 claims description 3
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims 4
- 230000008569 process Effects 0.000 abstract description 17
- 230000000694 effects Effects 0.000 abstract description 7
- 238000012986 modification Methods 0.000 abstract description 5
- 230000004048 modification Effects 0.000 abstract description 5
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 210000002345 respiratory system Anatomy 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 21
- 230000000052 comparative effect Effects 0.000 description 18
- 210000004027 cell Anatomy 0.000 description 12
- 108090000623 proteins and genes Proteins 0.000 description 11
- 102000004169 proteins and genes Human genes 0.000 description 11
- 238000012360 testing method Methods 0.000 description 10
- 230000002829 reductive effect Effects 0.000 description 8
- 241000282567 Macaca fascicularis Species 0.000 description 7
- 206010036790 Productive cough Diseases 0.000 description 7
- 210000003802 sputum Anatomy 0.000 description 7
- 208000024794 sputum Diseases 0.000 description 7
- 238000009423 ventilation Methods 0.000 description 7
- 239000012496 blank sample Substances 0.000 description 6
- 239000011248 coating agent Substances 0.000 description 6
- 238000000576 coating method Methods 0.000 description 6
- 230000028327 secretion Effects 0.000 description 6
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 5
- 230000021164 cell adhesion Effects 0.000 description 5
- 238000001727 in vivo Methods 0.000 description 5
- 210000004877 mucosa Anatomy 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 4
- 229940098773 bovine serum albumin Drugs 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 238000002386 leaching Methods 0.000 description 4
- 238000009832 plasma treatment Methods 0.000 description 4
- 206010021143 Hypoxia Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 230000002411 adverse Effects 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 239000003054 catalyst Substances 0.000 description 3
- 125000001153 fluoro group Chemical group F* 0.000 description 3
- 208000018875 hypoxemia Diseases 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- 238000002627 tracheal intubation Methods 0.000 description 3
- 206010003497 Asphyxia Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 239000012190 activator Substances 0.000 description 2
- 239000012752 auxiliary agent Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 238000003501 co-culture Methods 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000002950 fibroblast Anatomy 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000002715 modification method Methods 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 239000002861 polymer material Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000010069 protein adhesion Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 238000004381 surface treatment Methods 0.000 description 2
- 238000009210 therapy by ultrasound Methods 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 208000000884 Airway Obstruction Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 208000031481 Pathologic Constriction Diseases 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 108010087230 Sincalide Proteins 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 210000001552 airway epithelial cell Anatomy 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000003373 anti-fouling effect Effects 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000000861 blow drying Methods 0.000 description 1
- 239000003575 carbonaceous material Substances 0.000 description 1
- 238000010609 cell counting kit-8 assay Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000263 cytotoxicity test Toxicity 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 208000028659 discharge Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 238000004134 energy conservation Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000007306 functionalization reaction Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 231100000065 noncytotoxic Toxicity 0.000 description 1
- 230000002020 noncytotoxic effect Effects 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 239000011253 protective coating Substances 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- IZTQOLKUZKXIRV-YRVFCXMDSA-N sincalide Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](N)CC(O)=O)C1=CC=C(OS(O)(=O)=O)C=C1 IZTQOLKUZKXIRV-YRVFCXMDSA-N 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 230000036262 stenosis Effects 0.000 description 1
- 208000037804 stenosis Diseases 0.000 description 1
- 230000003075 superhydrophobic effect Effects 0.000 description 1
- 238000006557 surface reaction Methods 0.000 description 1
- 230000003746 surface roughness Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/10—Inorganic materials
- A61L29/106—Inorganic materials other than carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
- B08B3/04—Cleaning involving contact with liquid
- B08B3/10—Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration
- B08B3/12—Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration by sonic or ultrasonic vibrations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/02—Cleaning pipes or tubes or systems of pipes or tubes
- B08B9/027—Cleaning the internal surfaces; Removal of blockages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/424—Anti-adhesion agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
Abstract
The invention discloses a preparation method of a surface lubrication anti-adhesion medical pipeline. The prepared fluoride layer has long-acting stability, can effectively reduce the friction coefficient of the surface of the medical pipeline, has excellent anti-protein and anti-cell adhesion effects, can be widely used for surface modification of medical pipelines at respiratory tracts, digestive tracts and other parts, effectively protects the inner wall of a cavity, reduces the medical cost and relieves the discomfort of a patient in the process of catheterization. The invention also discloses a surface lubrication anti-adhesion medical pipeline.
Description
Technical Field
The invention relates to the technical field of surface functionalization of medical high polymer materials, in particular to a surface lubrication anti-adhesion medical pipeline and a preparation method thereof.
Background
The medical tube is the most commonly used equipment for clinical treatment and is widely applied to the fields of cardiovascular diseases, urology surgery, respiratory system diseases and the like. However, during the catheterization process, the interface friction between the tube and the mucosa of the cavity or the inner wall of the blood vessel is large, which easily causes discomfort for the patient and causes adverse reactions such as mucus secretion, wrinkles, mucosa injury, etc. (Jin W, et al. Tribology International 2018, 126: 29-38). On the other hand, the surface of the medical tube (made of polymer material) is easy to adsorb protein or cells, and complications such as inflammation and the like can be caused. For example, when proteins or airway epithelial cells are adsorbed on the surface of the endotracheal tube, tissue proliferation on the inner wall of the airway is stimulated, resulting in airway stenosis (Benjamin B, et al, Ann OtolRhinolLarynggol 2018, 127: 4). These problems can affect or even hinder the treatment process, causing pain to the patient. Therefore, imparting lubricity and anti-adhesion to the surface of medical tubing is a long felt and important performance requirement in the clinical field. The surface lubricity can be improved by coating a lubricating substance (such as silicone oil, polyvinylpyrrolidone and the like) on the surface of the medical pipeline, but the coating obtained by the method is adsorbed by physical action, has poor lasting stability, is easy to separate from the surface of the pipeline and loses the lubricating effect. The surface chemical grafting is to fix a functional coating on the surface of a material through a covalent bond, but the interface bonding strength of the functional coating and a pipeline substrate is weak, the surface is easy to separate, the coating preparation process is complicated, and an organic solvent is mostly adopted.
The surface plasma grafting modification has the advantages of simple process, convenient operation, good treatment effect, energy conservation and the like, and is widely applied to surface modification treatment of materials at present. The method can directly treat the surface of the material without damaging the properties of the material body. Patent CN200980145269.6 discloses a reactive-resistant protective coating prepared by halogen-containing plasma treatment, which can improve the corrosion resistance of solid substrate and improve the properties of hardness, toughness, thermal conductivity and dielectric constant of the base material. The patent CN201910349123.9 carries out plasma discharge treatment on the polyester fabric to obtainTo superhydrophobic modified surfaces. The water contact angle can be improved to 165 at mostoThe water contact angle can still be kept at 150 after the quasi-soaping for 400 times or the rubbing for 500 timesoAs described above. Therefore, the surface function of the medical pipeline modified by the plasma is a simple, convenient and effective surface modification method with strong general applicability, environmental protection and no toxicity.
Fluorination is an effective method for modifying the surface of materials. The surface fluorination can endow the material with various characteristics such as low surface energy, oxidation resistance, corrosion resistance and the like. Fluorine atoms have strong polarity, and can capture electrons when being combined with other elements to form a stable structure and generate low surface energy. While low surface energy is a sufficient condition to obtain adhesion resistance against proteins, bacteria, cells, etc. By treating the carbon material in a fluorine-containing atmosphere, the surface roughness is reduced, and the material has a low light emissivity, and the anti-aging performance of the surface of the material can be effectively improved (Kim J, et al. Chemical Communications, 2020, 56, 535-538). In the field of biological applications, studies have been reported to modify the Surface of Materials by fluorine and oxygen plasma to change their wettability and allow endothelial cells to selectively grow on the Surface (Kim, et al Applied Surface Science: A Journal developed to the Properties of Interfaces in comparison to the Synthesis & Behavior of Materials, 2016).
In addition, although various methods for functionalizing the surface of the medical pipeline exist at present, most methods only pay attention to the improvement of lubricity, and the research and development on the stability of the coating and related biological functions are lacked, so that the various performance requirements in the practical use of the pipeline are difficult to meet. Therefore, it is necessary to design a simple and effective medical pipeline lubrication anti-adhesion surface modification method starting from two aspects of physical properties and biological properties, so as to obtain a surface functionalized layer with excellent comprehensive properties and effectively reduce adverse effects on patients in the actual use process.
Disclosure of Invention
The invention aims to provide a surface lubrication anti-adhesion medical pipeline and a preparation method thereof. The invention leads the inner wall and the outer wall of the medical pipeline to be evenly fluorinated and grafted through the treatment of the fluorine plasma, has simple process flow and avoids using substances which are toxic to human bodies, such as catalysts and the like. In addition, the prepared fluorinated layer has excellent lubricating property, stability and low protein cell adhesion, can meet the long-term in-vivo use requirement, and can effectively reduce the friction damage problem and complications of the patient cavity.
The technical scheme of the invention for realizing the purpose is as follows:
A surface lubricating anti-adhesion medical pipeline and a preparation method thereof are disclosed, wherein a stable fluoride layer is formed on both the outer wall and the inner wall of the medical pipeline through fluorination treatment.
The medical pipeline is made of one of silica gel, polydimethylsiloxane, polyurethane elastomer, ethylene-vinyl acetate copolymer or polyvinyl chloride.
The temperature condition range of the fluorination treatment is 30-60 DEG CoC。
The time condition range of the fluorination treatment is 5-60 min.
The processing power range of the fluorination device is 10-100W.
The gas for fluorination treatment is one of fluorine gas, mixed gas of fluorine gas and argon gas or mixed gas of fluorine gas and nitrogen gas; alternatively, the fluorination treatment is performed using a fluorine plasma.
Before the fluorination treatment, the method also comprises the step of cleaning the medical pipeline.
The step of cleaning the medical tubing comprises:
and cleaning the medical pipeline by using acetone, ethanol and deionized water in sequence, and then drying to obtain the medical pipeline with a clean surface.
And after the fluorination treatment, ultrasonically cleaning the pipeline by using acetone, ethanol and water in sequence, and drying to obtain the medical pipeline with fluorinated inner and outer surfaces.
The surface lubrication anti-adhesion medical pipeline is prepared by adopting the preparation method of the surface lubrication anti-adhesion medical pipeline.
The invention has the beneficial effects that:
1. the method does not need to add any catalyst, activator and other auxiliary agents in the surface treatment process of the medical pipeline, and is simple and efficient. The surface treatment of the medical pipeline by the method can realize the functionalization of the inner wall and the outer wall of the medical pipeline simultaneously. Due to the large C-F bond energy, the fluoride layer obtained by the method has good long-acting stability and can fully meet the long-term use requirement under the in-vivo environment.
2. The fluorinated layer obtained by the method has excellent lubricating property. The fluoride layer forms a lubricating adsorption film in the friction process, so that the surface friction coefficient is effectively reduced to 50% at most. The high lubricity helps to reduce the friction between the medical pipeline and the inner wall of the cavity, so that the pipeline is smoothly inserted into the treatment part, and the discomfort and the pain of the patient are effectively relieved.
3. The fluorinated layer obtained by the method of the invention has excellent anti-adhesion capability. The fluorine plasma treatment ensures that the surface of the medical pipeline material has the characteristic of low surface energy, and effectively inhibits the adhesion, growth and reproduction of proteins and cells. The anti-adhesion capability of the fluorinated layers on the inner wall and the outer wall of the medical pipeline is beneficial to reducing the surface pollution of the medical pipeline material in the use process, reducing the generation of complications in or after operation and ensuring the use stability and safety.
Drawings
Fig. 1 is a graph showing results of total infrared reflectance (FTIR) spectrum tests of comparative example and example 1.
FIG. 2 is a graph showing the results of surface energy Spectroscopy (EDS) tests of examples 1-5, 9, 13-15.
In fig. 3, fig. 3 (a) is a schematic view of the results of the surface energy spectrum (EDS) tests before and after the ultrasound of examples 1 to 4, and fig. 3 (B) is a scan of the EDS distribution of the surface fluorine elements after the ultrasound of example 1.
FIG. 4 is a graph showing the results of the friction coefficient test of comparative example and examples 1 to 4.
FIG. 5 is a graph showing the results of cytotoxicity tests of comparative example and examples 1 to 4.
In FIG. 6, FIG. 6 (A) is a graph showing the results of the cell adhesion test of anti-Bovine Serum Albumin (BSA) of comparative example and examples 1-4, and FIG. 6 (B) is a graph showing the results of the cell adhesion test of mouse fibroblast (L929) of comparative example and examples 1-4.
In fig. 7, fig. 7 (a) is a graph showing the results of airway pressure test in the volume-controlled ventilation mode of comparative example and example 1, and fig. 7 (B) is a graph showing the results of tidal volume test in the pressure-controlled ventilation mode of comparative example and example 1.
Detailed Description
The following examples are given to illustrate the present invention and it is necessary to point out here that the following examples are given only for the purpose of further illustration of the invention and are not to be construed as limiting the scope of the invention.
Examples 1 to 15
The medical pipeline is respectively cleaned by acetone, ethanol and water in an ultrasonic way, and is dried by nitrogen. The medical tubing was subjected to fluorine plasma modification under certain conditions including treatment temperature, treatment time, treatment power, the specific settings of which are shown in table 1, to finally obtain the samples of examples 1-15. According to the surface lubrication anti-adhesion medical pipeline and the preparation method thereof, the stable fluoride layers are formed on the outer wall and the inner wall of the medical pipeline through fluorination treatment.
TABLE 1 fluorine plasma treatment conditions for medical tubing surfaces
Example numbering | Treatment temperature (C)oC) | Treatment time (min) | Treatment power (W) |
1 | 30 | 5 | 10 |
2 | 30 | 5 | 30 |
3 | 30 | 5 | 60 |
4 | 30 | 5 | 100 |
5 | 45 | 5 | 10 |
6 | 45 | 5 | 30 |
7 | 45 | 5 | 60 |
8 | 45 | 5 | 100 |
9 | 60 | 5 | 10 |
10 | 60 | 5 | 30 |
11 | 60 | 5 | 60 |
12 | 60 | 5 | 100 |
13 | 30 | 15 | 10 |
14 | 30 | 30 | 10 |
15 | 30 | 60 | 10 |
Wherein the processing power range of the fluorination device is 10-100W. The material of the medical pipeline can be one of silica gel, polydimethylsiloxane, polyurethane elastomer, ethylene-vinyl acetate copolymer or polyvinyl chloride. The gas for the fluorination treatment may be one of fluorine gas, a mixed gas of fluorine gas and argon gas, or a mixed gas of fluorine gas and nitrogen gas.
In some embodiments, prior to the fluorination process, a step of cleaning the medical tubing is also included.
In some embodiments, the step of cleaning the medical tubing comprises: and cleaning the medical pipeline by sequentially using acetone, ethanol and deionized water, and drying to obtain the medical pipeline with a clean surface.
In some embodiments, after the fluorination treatment, the tube is ultrasonically cleaned by acetone, ethanol and water in sequence, and after drying, the medical tube with fluorinated inner and outer surfaces is obtained.
The invention also describes a surface lubrication anti-adhesion medical pipeline which is prepared by adopting the preparation method of the surface lubrication anti-adhesion medical pipeline.
Comparative example
And ultrasonically cleaning the medical pipeline by using acetone, ethanol and water respectively, and blow-drying by using nitrogen to obtain an untreated blank sample.
Hereinafter, the surface structure and performance of the surface lubricating anti-adhesion fluorine fluoride layer prepared by the surface lubricating anti-adhesion medical pipeline and the preparation method thereof of the present invention will be described.
The surface lubricating anti-adhesion medical pipeline prepared by the method is characterized in surface structure and performance by adopting an X-ray Energy Dispersion Spectrum (EDS), a Fourier transform infrared spectrometer (FTIR) and a multifunctional friction and wear testing machine. In the aspect of biological performance, Bovine Serum Albumin (BSA) and mouse fibroblast (L929) are adopted to characterize the anti-adhesion performance of the medical pipeline. The in vivo biological performance of the medical pipeline is evaluated by adopting a non-human primate cynomolgus monkey tracheal intubation model, wherein a fiber bronchoscope is adopted to directly observe the injury condition of the airway mucosa after intubation. The anti-adhesion performance of the medical tubing was evaluated by sputum adhesion experiments.
Examples 1 to 15 and comparative examples are further described below with reference to the drawings. For the sake of simplicity, only some of the examples and comparative examples are selected as the control group for the different characterization results.
To characterize the invention and the inventionThe fluorination effect of the surface-lubricated anti-adhesion medical tubing prepared in the method of the invention was first determined using FTIR on a comparative blank sample and the sample of example 1. As shown in FIG. 1, the fluoridated medical tube has a C-F bond characteristic peak (1094.4 cm) in an infrared spectrum compared with an untreated medical tube-1) And 730 cm in length-1The characteristic peak of C-Cl bond is obviously reduced, which proves that the fluorine atom replaces the chlorine atom of the medical pipeline material body to realize surface fluorination in the plasma treatment process. The infrared results prove that the fluorination treatment successfully grafts fluorine atoms on the surface of the medical pipeline.
To examine the degree of fluorination of the surface-lubricated anti-adhesion medical tubing prepared under different treatment conditions, the surface fluorine content of examples 1-5, 9, 13-15 was examined using EDS. As shown in FIG. 2, the fluorination degree of the surface of the medical tubing material increased with the increase of the treatment power, temperature and time, and the fluorine content on the surface could reach 25%. Wherein the influence of the treatment power and the treatment time on the degree of fluorination is high and the influence of the treatment temperature is small. The EDS element distribution diagram shows that the fluorine elements on the surface of the medical pipeline are densely and uniformly distributed, and the uniform and stable fluorinated layer is proved to be formed.
To characterize the stability of the surface lubrication anti-adhesion medical tubing of the present invention and prepared by the method of the present invention, the samples of examples 1-4 were immersed in deionized water and sonicated in a sonicator for 12 hours, followed by EDS elemental content measurements, the results of which are shown in fig. 3 (a). From the results, the fluorine content of the surface of the sample of each example can be retained by more than 80% after ultrasonic treatment, and the fluorinated layer has good stability. As can be seen from fig. 3 (B), the fluorine elements on the surface are still uniformly distributed on the surface after the ultrasonic treatment.
To characterize the lubricity of the surface lubrication anti-adhesion medical tubing made according to the present invention and the method of the present invention, the average coefficient of wet friction (COF) of the comparative blank sample and the samples of examples 1-4 were characterized using a multifunctional friction and wear tester, and the results are shown in fig. 4. The result shows that the fluorinated layer can effectively reduce COF on the surface of the medical pipeline material, and the maximum COF can reach more than 50%. In the friction process, the fluoride layer can form a lubricating adsorption film between the surface of the medical pipeline material and the friction pair, so that the lubricating effect is achieved. Test results prove that the surface fluorination treatment can effectively reduce the frictional resistance in the movement process. The medical pipeline has large frictional resistance and can generate various adverse effects, for example, the friction of the outer wall of the medical pipeline is large, so that the tracheal mucosa is damaged; the friction force of the inner wall of the medical pipeline is large, and sputum and airway secretions are easy to attach to the surface, so that the intrapulmonary infection and even the asphyxia phenomenon can be caused. The inner wall and the outer wall of the medical pipeline prepared by the method form uniform fluoride layers, so that the inner surface and the outer surface of the medical pipeline prepared by the method generate a lubricating and anti-adhesion effect, the tracheal mucosa injury in the intubation process is favorably reduced, sputum and airway secretion are favorably sucked out, and the risk of intrapulmonary infection and asphyxia is reduced.
In order to characterize the cytotoxicity of the surface lubrication anti-adhesion medical tubing prepared according to the present invention and the method of the present invention, the blank sample of the comparative example and the samples of examples 1-4 were measured using the leaching solution method. Firstly, soaking the medical pipeline prepared by the method in a culture medium for 24 hours to prepare leaching liquor, then co-culturing the leaching liquor and L929 cells, and detecting the relative quantity of the cells by a CCK-8 method after 24 hours. Meanwhile, a phenol solution was set as a positive control. As shown in the results of FIG. 5, the number of cells cultured by the leaching solution of examples 1 to 4 is more than 90% of the comparative example, which proves that the fluorinated medical tubing material is non-cytotoxic, i.e., the fluorinated layer after the fluorination treatment has good biocompatibility.
In order to characterize the protein and cell adhesion resistance of the surface lubrication anti-adhesion medical tubing prepared according to the present invention and the method of the present invention, the blank sample of the comparative example and the samples of examples 1-4 were co-cultured with BSA protein and L929 cells, respectively, and the results are shown in FIGS. 6 (A), (B). BSA protein was detected after 1 hour of co-culture, and cells were detected after 24 hours of co-culture. The results show that the medical pipeline prepared by the method and the invention has reduced adsorbed protein and cell number with the increase of the fluorine element content on the surface, and prove that the fluoride layer has good anti-adhesion capability. The reason is that the surface energy of the medical pipeline material after the fluorination treatment is reduced, the hydrophobicity is increased, and the adhesion of protein and cells is not facilitated. The reduction of the adhesion amount of protein and cells is beneficial to the anti-fouling of the surface of the medical pipeline in the in-vivo use process, and simultaneously reduces the generation of inflammation and complication problems.
In order to characterize the anti-adhesion performance of the surface lubricating anti-adhesion medical pipeline inner wall prepared by the method, the cynomolgus monkey pneumonia trachea cannula in-vivo experiment is carried out, a blank sample of a comparative example and a sample of example 1 are respectively placed in the main airway of the cynomolgus monkey, and assisted ventilation treatment is carried out for 10-12h by using a respirator, and the result is shown in figure 7. FIG. 7 (A) shows that in the volume-controlled ventilation mode, after the ventilator was ventilated for 8 hours with a tidal volume of 6-8ml/kg, the cynomolgus monkey in the comparative example gradually increased the airway pressure of the catheter by 20cmH due to the adhesion and blockage of sputum and secretions2O, and the sputum and secretion attachment of the cynomolgus monkey of example 1 was significantly reduced and the airway pressure was stabilized within the normal range (15 cmH)2O or less). FIG. 7 (B) shows ventilator delivery under 15cmH in pressure controlled ventilation mode2After the positive pressure ventilation of O for 8 h, the tidal volume of the cynomolgus monkey of the comparative example gradually decreases to below 5ml/kg due to the blockage of the catheter by the attached sputum and secretion, and hypoxemia (blood oxygen saturation) appears<92%), while the cynomolgus monkey of example 1 maintained a normal tidal volume of 6-8ml/kg due to a significant reduction in sputum and secretion attachment, and did not show hypoxemia (blood oxygen saturation) >95%). The results prove that the fluoridized medical pipeline can effectively reduce the phenomena of airway obstruction, hypoxemia and the like in the ventilation process.
The invention discloses a surface lubrication anti-adhesion medical pipeline and a preparation method thereof, no catalyst, activator and other auxiliary agents are required to be added additionally, a prepared fluoride layer has no biotoxicity, and adverse effects on human bodies caused by organic substance residues are effectively avoided. The fluoride layer prepared by the method has excellent lubricity, is beneficial to reducing the friction between the medical pipeline and the cavity wall, ensures that the medical pipeline is smoothly inserted into a treatment part, and effectively relieves the discomfort and pain of a patient. The fluoride layer also has excellent protein and cell adhesion resistance, can inhibit the adhesion, growth and reproduction of proteins and cells, reduces the surface pollution of the medical pipeline material in the use process, reduces the generation of complications in or after operation, ensures the stability and safety of use, and meets the use requirement of long-term treatment.
It should be noted that the various features described in the foregoing embodiments may be combined in any suitable manner without contradiction. The present invention is not described in detail in terms of various possible combinations to avoid unnecessary repetition.
The present invention has been described in detail with reference to the embodiments, which are illustrative rather than restrictive, and variations and modifications may be made without departing from the general inventive concept within the scope of the present invention.
Claims (10)
1. A preparation method of a surface lubrication anti-adhesion medical pipeline is characterized in that a stable fluoride layer is formed on both the outer wall and the inner wall of the medical pipeline through fluorination treatment.
2. The method for preparing the surface-lubricating anti-adhesion medical pipeline according to claim 1, wherein the material of the medical pipeline is one of silica gel, polydimethylsiloxane, polyurethane elastomer, ethylene-vinyl acetate copolymer or polyvinyl chloride.
3. The method for preparing the surface-lubricating anti-adhesion medical pipeline according to claim 1, wherein the temperature condition of the fluorination treatment ranges from 30 to 60 degreesoC。
4. The method for preparing the surface-lubricating anti-adhesion medical pipeline according to claim 1, wherein the fluorination treatment time is 5-60 min.
5. The method for preparing the surface lubricating anti-adhesion medical pipeline according to claim 1, wherein the fluorination treatment device has a treatment power range of 10-100W.
6. The method for preparing the surface lubricating anti-adhesion medical pipeline according to claim 1, wherein the gas for the fluorination treatment is one of fluorine gas, a mixed gas of fluorine gas and argon gas or a mixed gas of fluorine gas and nitrogen gas; alternatively, the fluorination treatment is performed using a fluorine plasma.
7. The method of preparing a surface lubricating anti-adhesion medical tubing of any of claims 1-6, further comprising the step of cleaning the medical tubing prior to the fluorination treatment.
8. The method of preparing a surface-lubricated anti-adhesion medical tubing of claim 7, wherein the step of cleaning the medical tubing comprises:
and cleaning the medical pipeline by using acetone, ethanol and deionized water in sequence, and then drying to obtain the medical pipeline with a clean surface.
9. The method for preparing the surface lubrication anti-adhesion medical pipeline according to claim 1, wherein after the fluorination treatment, the pipeline is cleaned by ultrasonic waves sequentially through acetone, ethanol and water, and after drying, the medical pipeline with the fluorinated inner surface and the fluorinated outer surface is obtained.
10. A surface lubrication anti-adhesion medical tube, characterized in that it is prepared by the method of claim 1-9.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110051269.2A CN114762741A (en) | 2021-01-14 | 2021-01-14 | Surface lubrication anti-adhesion medical pipeline and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110051269.2A CN114762741A (en) | 2021-01-14 | 2021-01-14 | Surface lubrication anti-adhesion medical pipeline and preparation method thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CN114762741A true CN114762741A (en) | 2022-07-19 |
Family
ID=82362968
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202110051269.2A Pending CN114762741A (en) | 2021-01-14 | 2021-01-14 | Surface lubrication anti-adhesion medical pipeline and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN114762741A (en) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3884325T2 (en) * | 1987-09-23 | 1994-03-17 | Inst Rechappliquee Sur Les Pol | Surface modified plastic products with improved blood tolerance and lower thrombogenicity and process for their production. |
JP2003225311A (en) * | 2002-02-01 | 2003-08-12 | Naotoshi Nakajima | Surface-treated medical appliance for examination and treatment, ophthalmic medical appliance or blood treatment medical appliance |
US20060122560A1 (en) * | 2004-12-07 | 2006-06-08 | Robert Burgmeier | Medical devices and processes for preparing same |
CN101880401A (en) * | 2010-06-24 | 2010-11-10 | 洛阳森蓝化工材料科技有限公司 | Polymer surface fluorination technique |
US20110022030A1 (en) * | 2007-12-21 | 2011-01-27 | Volker Marx | Fluorinated polymers in medical devices |
-
2021
- 2021-01-14 CN CN202110051269.2A patent/CN114762741A/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3884325T2 (en) * | 1987-09-23 | 1994-03-17 | Inst Rechappliquee Sur Les Pol | Surface modified plastic products with improved blood tolerance and lower thrombogenicity and process for their production. |
JP2003225311A (en) * | 2002-02-01 | 2003-08-12 | Naotoshi Nakajima | Surface-treated medical appliance for examination and treatment, ophthalmic medical appliance or blood treatment medical appliance |
US20060122560A1 (en) * | 2004-12-07 | 2006-06-08 | Robert Burgmeier | Medical devices and processes for preparing same |
US20110022030A1 (en) * | 2007-12-21 | 2011-01-27 | Volker Marx | Fluorinated polymers in medical devices |
CN101880401A (en) * | 2010-06-24 | 2010-11-10 | 洛阳森蓝化工材料科技有限公司 | Polymer surface fluorination technique |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101455861B (en) | Lubricity coatings preparation method on the medical catheter polymers surface | |
CN111097072B (en) | Preparation method of hydrophilic lubricating coating with strong interface bonding on surface of polymer medical product | |
EP2982390B1 (en) | Medical device and method for manufacturing medical device | |
EP3484535B1 (en) | Hygienic medical devices having hydrophilic coating and methods of forming the same | |
KR20090084847A (en) | Compositions and devices comprising silicone and specific polyphosphazenes | |
JPWO2006095766A1 (en) | Durability wet surface coating excellent in durability, surface coating method, and medical device having the surface coating | |
WO2010070085A2 (en) | Method for producing a medical device with a cross-linked hydrophilic coating | |
CN106334219A (en) | Hyaluronic acid modified hydrophilic lubricating coating, preparation method and applications thereof | |
CN114762741A (en) | Surface lubrication anti-adhesion medical pipeline and preparation method thereof | |
US8957173B2 (en) | Resin product for medical use and respiration-assisting tube | |
Bazaka et al. | Polymer encapsulation of magnesium to control biodegradability and biocompatibility | |
CN117379605A (en) | Medical silica gel surface hydrophilic modified coating and preparation method and application thereof | |
CN110404120A (en) | A kind of preparation method of front end softening catheter | |
CN115814172B (en) | Anti-fouling wear-resistant hydrophilic lubricating coating grafted on surface of medical instrument and preparation method thereof | |
CN110804200A (en) | Medical tube and preparation method thereof | |
JP4744189B2 (en) | Catheter manufacturing method | |
CN110804201A (en) | Hydrogel lubrication catheter and preparation method thereof | |
CN107281614B (en) | Hydrophilic coating sputum suction tube and implementation method thereof | |
CN114748702A (en) | Hydrogel coating for eustachian tube balloon dilatation catheter and preparation method thereof | |
CN112657041A (en) | Method for preparing ultra-smooth three-cavity catheter | |
JPH10201840A (en) | Easily slipperable medical treatment appliance and its production | |
CN117159813A (en) | Medical catheter with hydrophilic coating and preparation method thereof | |
Liu et al. | Hydrogel coatings on universal medical devices with water-responsive Janus adhesion and acidity-triggered transformation for adaptive antibacterial treatment and fluorescence diagnosis | |
CN111053952A (en) | Preparation method of catheter | |
CN110665070B (en) | Medical coating with hydrophilic lubricating surface and preparation method thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20220719 |