CN112657041A - Method for preparing ultra-smooth three-cavity catheter - Google Patents
Method for preparing ultra-smooth three-cavity catheter Download PDFInfo
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- CN112657041A CN112657041A CN202110028106.2A CN202110028106A CN112657041A CN 112657041 A CN112657041 A CN 112657041A CN 202110028106 A CN202110028106 A CN 202110028106A CN 112657041 A CN112657041 A CN 112657041A
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- 238000000034 method Methods 0.000 title claims abstract description 30
- 238000000576 coating method Methods 0.000 claims abstract description 69
- 239000011248 coating agent Substances 0.000 claims abstract description 68
- 239000007788 liquid Substances 0.000 claims abstract description 50
- 238000003618 dip coating Methods 0.000 claims abstract description 34
- 238000007664 blowing Methods 0.000 claims abstract description 20
- 238000010438 heat treatment Methods 0.000 claims abstract description 17
- 238000009832 plasma treatment Methods 0.000 claims abstract description 14
- 230000001954 sterilising effect Effects 0.000 claims abstract description 14
- 238000011010 flushing procedure Methods 0.000 claims abstract description 12
- 238000001723 curing Methods 0.000 claims abstract description 8
- 238000000605 extraction Methods 0.000 claims abstract description 8
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 18
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 18
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 15
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 15
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 13
- 238000001035 drying Methods 0.000 claims description 12
- -1 polyoxyethylene Polymers 0.000 claims description 11
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 10
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 10
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 10
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 10
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- 239000011148 porous material Substances 0.000 claims description 9
- OTYYBJNSLLBAGE-UHFFFAOYSA-N CN1C(CCC1)=O.[N] Chemical compound CN1C(CCC1)=O.[N] OTYYBJNSLLBAGE-UHFFFAOYSA-N 0.000 claims description 7
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 7
- 239000004952 Polyamide Substances 0.000 claims description 6
- 239000004695 Polyether sulfone Substances 0.000 claims description 6
- 229920002647 polyamide Polymers 0.000 claims description 6
- 229920006393 polyether sulfone Polymers 0.000 claims description 6
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 6
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 6
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 5
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 claims description 4
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- 239000003153 chemical reaction reagent Substances 0.000 claims description 3
- 239000004816 latex Substances 0.000 claims description 3
- 229920000126 latex Polymers 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 239000000741 silica gel Substances 0.000 claims description 3
- 229910002027 silica gel Inorganic materials 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- 229910001220 stainless steel Inorganic materials 0.000 claims description 3
- 239000010935 stainless steel Substances 0.000 claims description 3
- 229920000642 polymer Polymers 0.000 claims description 2
- 229920013746 hydrophilic polyethylene oxide Polymers 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 abstract description 4
- 238000009423 ventilation Methods 0.000 abstract description 2
- 238000004806 packaging method and process Methods 0.000 abstract 1
- 229920002635 polyurethane Polymers 0.000 description 17
- 239000004814 polyurethane Substances 0.000 description 17
- 238000003756 stirring Methods 0.000 description 12
- 238000002791 soaking Methods 0.000 description 5
- 238000005303 weighing Methods 0.000 description 5
- 230000029142 excretion Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- 229920001477 hydrophilic polymer Polymers 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 230000002485 urinary effect Effects 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
Images
Abstract
The invention belongs to the technical field of medical instruments, and particularly discloses a method for preparing an ultra-smooth three-cavity catheter, which comprises the following steps: the first step is as follows: preparing super-smooth coating liquid, and dividing the super-smooth coating liquid into Base layer coating liquid and Top layer coating liquid; the second step is that: connecting a drainage cavity of the three-cavity catheter with a joint on a plate, connecting a flushing cavity with a plugging joint, and carrying out plasma treatment on a tube body of the three-cavity catheter; the third step: dip-coating the three-cavity catheter subjected to plasma treatment with a Base layer coating solution, blowing after extraction, heating and curing, dip-coating the Top layer coating solution again, blowing after extraction, and heating and curing; the fourth step: sterilizing, packaging and sterilizing the three-cavity catheter treated in the third step; the drainage cavity is blocked by adopting ventilation and the blocking joint in the drainage cavity, so that the risks of unsmooth drainage or cavity blocking caused by the residual ultra-smooth coating liquid in the drainage cavity and the reduction of the flow of the drainage cavity after the three-cavity catheter is dip-coated are overcome.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a method for preparing an ultra-smooth three-cavity catheter.
Background
At present, a catheter is used as a common urological instrument in hospitals, urine is led out by inserting a urinary bladder through a urethra, and the urinary catheter is of great importance to patients who cannot independently urinate, a three-cavity catheter integrates excretion and washing, the urinary catheter is widely applied clinically at present, the infection problem of the urinary tract is more concerned by the wide application of the catheter, the ultra-slip treatment of the catheter has important significance for reducing urinary tract infection, the preparation methods of ultra-slip catheter coatings are many, the ultra-slip performance of the three-cavity catheter can be realized by methods such as dip coating, spraying, surface grafting and the like, the dip coating method is simple in operation, low in cost and most widely applied, but the blockage of an excretion cavity and a washing cavity is easily caused by a dip coating mode, and the function and the performance of the three-cavity catheter are greatly influenced.
Disclosure of Invention
In order to solve the technical problems, the preparation method of the ultra-smooth three-cavity catheter is researched and developed by the technicians in the field.
In order to achieve the purpose, the technical scheme of the invention is as follows:
a method for preparing an ultra-smooth three-cavity catheter comprises the following steps:
the first step is as follows: preparing super-smooth coating liquid, and dividing the super-smooth coating liquid into Base layer coating liquid and Top layer coating liquid;
the second step is that: connecting a drainage cavity of the three-cavity catheter with a joint on a plate, connecting a flushing cavity with a plugging joint, and carrying out plasma treatment on a tube body of the three-cavity catheter;
the third step: dip-coating the three-cavity catheter subjected to plasma treatment with a Base layer coating solution, blowing after extraction, heating and curing, dip-coating the Top layer coating solution again, blowing after extraction, and heating and curing;
the fourth step: and (4) sterilizing, bagging and sterilizing the three-cavity catheter treated in the third step.
Further, three chamber catheters are three chamber latex catheters or three chamber silica gel catheters.
Further, the super-slippery coating liquid is selected from one or more than two of medical grade polyvinylpyrrolidone, polyoxyethylene hydrophilic polymer, glycerol and polyethylene glycol.
Further, the reagents used in the Base layer coating liquid and the Top layer coating liquid are selected from one or more of methanol, ethanol, ethyl acetate, butyl acetate, dichloromethane, acetone, dimethyl sulfoxide, dimethylformamide, nitrogen methyl pyrrolidone, polyoxyethylene and tetrahydrofuran.
Further, the solid content of the super-smooth coating liquid is 0.5% -25%, and the viscosity is in the range of 0.5-25 mpas.
Furthermore, a threaded hole matched with the external thread of the joint is formed in the middle of the plate, a pore channel is formed in the joint, and the pore diameter of the pore channel is 0.5-3 mm.
Further, the joint is connected with compressed air equipment through a plate, the pressure range of the compressed air equipment is 0.01-0.50MPa, and the blowing time range is 0-360 s.
Further, the plate is made of polyamide, polytetrafluoroethylene or polyether sulfone or stainless steel, and the plugging joint is made of polyamide, polytetrafluoroethylene or polyether sulfone.
Further, the dip-coating time of the dip-coating Base layer coating liquid and the dip-coating Top layer coating liquid is 10-80s, the air blowing time is 20-80s, the heating and drying temperature of the pipe body after dip-coating is 50-110 ℃, and the drying time is 0.5-10 h.
Compared with the prior art, the method for preparing the ultra-smooth three-cavity catheter provided by the invention has a distinctive structure, the flushing cavity is blocked by adopting the ventilation and blocking joint in the drainage cavity, the reduction of the flow of the drainage cavity after the three-cavity catheter is dip-coated and the risk of unsmooth drainage or cavity blocking caused by the residue of ultra-smooth coating liquid in the flushing cavity are overcome, and the ultra-smooth performance of the three-cavity catheter is realized.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a schematic view of a three-cavity catheter of the method for preparing a super-smooth three-cavity catheter of the present invention.
FIG. 2 is a schematic joint diagram of a method for preparing a super-smooth three-cavity catheter according to the present invention.
FIG. 3 is a schematic view of a plugging joint of the method for preparing the ultra-smooth three-cavity catheter of the invention.
FIG. 4 is a side view of a sheet material for a method of making a super-lubricious three-lumen catheter of the present invention.
FIG. 5 is a top view of a plate for a method of preparing a super-lubricious three-lumen catheter of the present invention.
FIG. 6 is a graph showing the results of 30 tests of friction coefficients in examples 1 and 2 and 30 tests of friction coefficients after 30 days of immersion.
In the figure: 1 is a drainage cavity, 2 is a flushing cavity, 3 is an inflation cavity, 4 is a joint, 5 is a plugging joint, and 6 is a plate.
Detailed Description
The technical solution in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
As shown in fig. 1 to 6, a method for preparing a super-lubricity three-cavity catheter as a preferred embodiment of the present invention comprises the following steps:
the first step is as follows: preparing super-smooth coating liquid, and dividing the super-smooth coating liquid into Base layer coating liquid and Top layer coating liquid;
the second step is that: connecting a drainage cavity 1 of the three-cavity catheter with a joint 4 on a plate 6, connecting a flushing cavity 2 with a plugging joint 5, and carrying out plasma treatment on a tube body of the three-cavity catheter;
the third step: dip-coating the three-cavity catheter subjected to plasma treatment with a Base layer coating solution, blowing after extraction, heating and curing, dip-coating the Top layer coating solution again, blowing after extraction, and heating and curing;
the fourth step: and (4) sterilizing, bagging and sterilizing the three-cavity catheter treated in the third step.
On the basis of above-mentioned embodiment, three chamber catheters can be three chamber latex catheters or three chamber silica gel catheters, nevertheless do not restrict the material of three chamber catheters, and is common to be two kinds of materials of above-mentioned.
On the basis of the above embodiments, the ultra-smooth coating liquid is selected from any one or more of medical grade polyvinylpyrrolidone, polyoxyethylene hydrophilic polymer, glycerol and polyethylene glycol.
On the basis of the above embodiments, the reagents used in the Base layer coating liquid and the Top layer coating liquid are selected from one or more of methanol, ethanol, ethyl acetate, butyl acetate, dichloromethane, acetone, dimethyl sulfoxide, dimethylformamide, nitrogen methyl pyrrolidone, polyoxyethylene, and tetrahydrofuran, and the selected polymer is 5% to 15% polyurethane used for supporting the Base layer and the Top layer.
And more specifically, the solid content of the ultra-smooth coating liquid is 0.5-25%, and the viscosity is in the range of 0.5-25 mpas.
In the above embodiment, the middle of the plate 6 is provided with a threaded hole matched with the external thread of the joint 4, and the inside of the joint 4 is provided with a pore channel, and the pore diameter of the pore channel is 0.5-3 mm.
And the joint is connected with compressed air equipment through a plate 6, the pressure range of the compressed air equipment is 0.01-0.50MPa, and the blowing time range is 0-360 s.
In the above embodiment, the plate 6 is made of polyamide, polytetrafluoroethylene, polyethersulfone or stainless steel, and the plugging joint 5 is made of polyamide, polytetrafluoroethylene or polyethersulfone.
In the embodiment, the dip-coating time of the Base layer coating liquid and the dip-coating time of the Top layer coating liquid are both 10-80s, the air blowing time is 20-80s, the heating and drying temperature of the pipe body after dip-coating is 50-110 ℃, and the drying time is 0.5-10 h.
Example 1
The first step is as follows: preparing a Base layer super-smooth coating liquid: firstly, weighing 40g of polyurethane, putting the polyurethane into a 1000mL beaker, adding 80mL of nitrogen methyl pyrrolidone, stirring until the polyurethane is dissolved, adding 120mL of tetrahydrofuran, 60mL of dichloromethane and 80mL of methanol, and stirring to obtain a Base layer coating liquid.
Preparing a Top layer super-smooth coating liquid: firstly, weighing 10g of polyurethane, placing the polyurethane into a 1000mL beaker, adding 80mL of nitrogen methyl pyrrolidone, stirring until the polyurethane is dissolved, adding 120mL of tetrahydrofuran, 60mL of dichloromethane and 80mL of methanol, stirring, adding 10g of polyvinylpyrrolidone, stirring until the polyvinylpyrrolidone is dissolved, and obtaining a Top layer coating solution after the polyvinylpyrrolidone is clear and transparent.
The second step is that: the three-cavity catheter is placed on the joint 4 of the plate 6 from the end of the drainage cavity 1, the flushing cavity 2 is plugged by the plugging joint 5, and the body of the three-cavity catheter is subjected to plasma treatment.
The third step: setting the pressure on a compressed air device to be 0.03MPa in the dip-coating process, dip-coating the three-cavity catheter after plasma treatment into Base layer coating liquid at 20 ℃, dip-coating for 30s, blowing 25s by the compressed air device after being lifted out, heating and drying for 1.5h at 50 ℃, dip-coating into Top layer coating liquid again for 30s, blowing 25s by the compressed air device after being lifted out, and heating and drying for 10h at 50 ℃.
The fourth step: and (4) sterilizing, bagging and sterilizing the three-cavity catheter treated in the third step.
Example 2
The first step is as follows: preparing a Base layer super-smooth coating liquid: firstly, weighing 30g of polyurethane, putting the polyurethane into a 1000mL beaker, adding 80mL of nitrogen methyl pyrrolidone, stirring until the polyurethane is dissolved, and then adding 100mL of tetrahydrofuran, 160mL of butyl acetate and 100mL of methanol to obtain a Base layer coating liquid.
Preparing a Top layer super-smooth coating liquid: firstly, weighing 4g of polyurethane, placing the polyurethane into a 1000mL beaker, adding 80mL of nitrogen methyl pyrrolidone, stirring and dissolving, adding 140mL of tetrahydrofuran and 240mL of ethyl acetate, stirring, adding 16g of polyvinylpyrrolidone, and stirring until the polyvinylpyrrolidone is completely dissolved to obtain a Top layer coating solution.
The second step is that: the three-cavity catheter is placed on the joint 4 of the plate 6 from the end of the drainage cavity 1, the flushing cavity 2 is plugged by the plugging joint 5, and the body of the three-cavity catheter is subjected to plasma treatment.
The third step: setting the pressure on a compressed air device to be 0.1MPa in the dip-coating process, dip-coating the three-cavity catheter after plasma treatment into Base layer coating liquid at 20 ℃, dip-coating for 50s, blowing air for 25s by the compressed air device after being extracted, heating and drying for 1h at 80 ℃, dip-coating into Top layer coating liquid again for 50s, blowing air for 25s by the compressed air device after being extracted, and heating and drying for 6h at 80 ℃.
The fourth step: and (4) sterilizing, bagging and sterilizing the three-cavity catheter treated in the third step.
Example 3
The first step is as follows: preparing a Base layer super-smooth coating liquid: firstly, 60g of polyurethane is weighed and placed into a 1000mL beaker, 80mL of dimethylformamide is added and stirred until the polyurethane is dissolved, and then 120mL of ethanol, 60mL of ethyl acetate and 100mL of dimethyl sulfoxide are added to obtain a Base layer coating solution.
Preparing a Top layer super-smooth coating liquid: firstly, weighing 8g of polyurethane, putting the polyurethane into a 1000mL beaker, adding 80mL of dimethylformamide, stirring until the polyurethane is dissolved, adding 120mL of ethanol, 60mL of ethyl acetate and 100mL of dimethyl sulfoxide, stirring, adding 32g of polyvinylpyrrolidone, and stirring until the polyvinylpyrrolidone is completely dissolved to obtain a Top layer coating solution.
The second step is that: the three-cavity catheter is placed on the joint 4 of the plate 6 from the end of the drainage cavity 1, the flushing cavity 2 is plugged by the plugging joint 5, and the body of the three-cavity catheter is subjected to plasma treatment.
The third step: setting the pressure on a compressed air device to be 0.3MPa in the dip-coating process, dip-coating the three-cavity catheter after plasma treatment into Base layer coating liquid at 20 ℃, dip-coating for 30s, blowing air for 25s by the compressed air device after being lifted out, heating and drying for 0.5h at 110 ℃, dip-coating into Top layer coating liquid again for 30s, blowing air for 25s by the compressed air device after being lifted out, and heating and drying for 2h at 110 ℃.
The fourth step: and (4) sterilizing, bagging and sterilizing the three-cavity catheter treated in the third step.
In order to further know the ultra-lubricity of the three-cavity catheter, the performance of the three-cavity catheter after dip coating is detected.
And the test results are as follows:
1. lubricating property and firmness
According to a test method of a standard test model for evaluating the surface sliding performance of YY/T1536-2017 non-intravascular catheter, the soaked ultra-smooth three-cavity catheter is subjected to 30 friction coefficient tests, the coated ultra-smooth three-cavity catheter is placed in simulated urine to be soaked for 30 days and then is subjected to 30 friction coefficient tests, the friction coefficients are compared for 30 times, the friction coefficients are all smaller than 0.1, the coating is better in lubricity and firmness, and the result is shown in figure 6.
2. Flow measurement
The coated ultra-smooth three-cavity catheter is soaked in simulated urine for 30 days, and the flow of the excretion cavity and the flushing cavity is tested according to a test method of YY0325-2016 aseptic disposable catheter, and the result is shown in Table 1, and the flow of the coated ultra-smooth three-cavity catheter can still meet the requirement after being soaked for 30 days.
TABLE 1 flow test results for different samples
| Sample (I) | Drainage lumen mL/min | Flushing cavity mL/min |
| Standard 3-16Fr | ≥100 | ≥25 |
| Uncoated 3-16Fr | 310 | 38 |
| Soaking for 30 days for 3-16Fr after coating | 320 | 45 |
| Soaking for 30 days for 3-16Fr after coating | 330 | 50 |
| Soaking for 30 days for 3-16Fr after coating | 330 | 51 |
| Soaking for 30 days for 3-16Fr after coating | 325 | 47 |
| Soaking for 30 days for 3-16Fr after coating | 320 | 41 |
Finally, it should also be noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.
The embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (9)
1. A method for preparing an ultra-smooth three-cavity catheter is characterized by comprising the following steps:
the first step is as follows: preparing super-smooth coating liquid, and dividing the super-smooth coating liquid into Base layer coating liquid and Top layer coating liquid;
the second step is that: connecting a drainage cavity of the three-cavity catheter with a joint on a plate, connecting a flushing cavity with a plugging joint, and carrying out plasma treatment on a tube body of the three-cavity catheter;
the third step: dip-coating the three-cavity catheter subjected to plasma treatment with a Base layer coating solution, blowing after extraction, heating and curing, dip-coating the Top layer coating solution again, blowing after extraction, and heating and curing;
the fourth step: and (4) sterilizing, bagging and sterilizing the three-cavity catheter treated in the third step.
2. The method for preparing the ultra-smooth three-cavity catheter according to claim 1, wherein the three-cavity catheter is a three-cavity latex catheter or a three-cavity silica gel catheter.
3. The method for preparing the ultra-smooth three-cavity catheter according to the claim 2, wherein the ultra-smooth coating liquid is selected from one or more of medical grade polyvinylpyrrolidone, hydrophilic polyethylene oxide polymer, glycerol and polyethylene glycol.
4. The method for preparing a super-smooth three-cavity catheter according to claim 3, wherein the reagents used in the Base layer coating liquid and the Top layer coating liquid are selected from one or more of methanol, ethanol, ethyl acetate, butyl acetate, dichloromethane, acetone, dimethyl sulfoxide, dimethylformamide, nitrogen methyl pyrrolidone, polyoxyethylene and tetrahydrofuran.
5. The method for preparing the ultra-smooth three-cavity catheter according to claim 1, wherein the solid content of the ultra-smooth coating liquid is 0.5% -25%, and the viscosity is 0.5-25 mpas.
6. The method for preparing the ultra-smooth three-cavity catheter according to claim 1, wherein a threaded hole matched with the external thread of the connector is formed in the middle of the plate, a pore passage is formed in the connector, and the pore diameter of the pore passage is 0.5-3 mm.
7. The method for preparing the ultra-smooth three-cavity catheter according to claim 1, wherein the joint is connected with a compressed air device through a plate, the pressure range of the compressed air device is 0.01-0.50MPa, and the air blowing time range is 0-360 s.
8. The method for preparing the ultra-smooth three-cavity catheter according to claim 1, wherein the plate is made of polyamide, polytetrafluoroethylene, polyether sulfone or stainless steel, and the plugging joint is made of polyamide, polytetrafluoroethylene or polyether sulfone.
9. The method for preparing the ultra-smooth three-cavity catheter according to claim 1, wherein the dip-coating time of the Base layer coating liquid and the dip-coating time of the Top layer coating liquid are both 10-80s, the air blowing time is 20-80s, the heating and drying temperature of the tube body after dip-coating is 50-110 ℃, and the drying time is 0.5h-10 h.
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| CN113367759A (en) * | 2021-06-16 | 2021-09-10 | 成都昌华科技有限责任公司 | Disposable controllable unilateral trachea obturator and preparation process thereof |
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