CN111282313A - Solid phase extraction column filling device - Google Patents
Solid phase extraction column filling device Download PDFInfo
- Publication number
- CN111282313A CN111282313A CN202010234665.4A CN202010234665A CN111282313A CN 111282313 A CN111282313 A CN 111282313A CN 202010234665 A CN202010234665 A CN 202010234665A CN 111282313 A CN111282313 A CN 111282313A
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- CN
- China
- Prior art keywords
- driving cylinder
- phase extraction
- extraction column
- solid phase
- switch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 238000002414 normal-phase solid-phase extraction Methods 0.000 title claims abstract description 30
- 230000001105 regulatory effect Effects 0.000 claims description 16
- 238000012856 packing Methods 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 239000000945 filler Substances 0.000 description 10
- 239000000523 sample Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 4
- 238000000605 extraction Methods 0.000 description 2
- 239000012472 biological sample Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
Abstract
The invention relates to a solid phase extraction column production device, in particular to a solid phase extraction column filling device. It is characterized by comprising a bottom plate which is horizontally arranged and is provided with a bracket; the support is provided with a vertically arranged driving cylinder, the driving cylinder is connected with a driving system, a piston rod of the driving cylinder faces downwards, and a cylindrical pressure head is concentrically arranged at the lower end of the piston rod of the driving cylinder. A limiting block is arranged on the bottom plate below the columnar pressure head, a clamping hole is formed in the top of the limiting block, and the clamping hole and the columnar pressure head are arranged concentrically. The difference between the solid-phase extraction columns prepared by adopting the solid-phase extraction column filling device is small, and the accuracy of a processing result is high.
Description
Technical Field
The invention relates to solid phase extraction column production equipment, in particular to a solid phase extraction column filling device capable of realizing stable, continuous and uniform preparation of a solid phase extraction column.
Background
The solid phase extraction column is a sample pretreatment device developed from a chromatographic column and used for extraction, separation and concentration. The method is mainly applied to sample pretreatment of target compounds in various foods, agricultural and livestock products, environmental samples and biological samples. The principle of sample treatment by the phase extraction column is as follows: separating by selective adsorption and selective elution liquid chromatography. The solid phase extraction column generally comprises a column tube, packing and sieve plates
Currently, the solid phase extraction column is manufactured by adopting a manual filling method in the industry, namely, workers firstly fill quantitative fillers into a column tube. The packing in the column tube is then compacted by means of a manual ram. The screen plate is then loaded into the column. The solid phase extraction column is used for carrying out rapid pretreatment on a sample, and the smaller the difference between the solid phase extraction columns is, the more stable the sample treatment is. However, when a manual filling method is adopted, workers cannot guarantee that the pressing force is always kept every time, so that the upper and lower densities of fillers filled in a column tube are inconsistent, the difference between solid-phase extraction columns is large, the error of sample pretreatment is large, and the accuracy of a treatment result is poor.
Disclosure of Invention
The technical problem to be solved by the invention is to provide a solid phase extraction column filling device of a solid phase extraction column, the difference between solid phase extraction columns prepared by adopting the solid phase extraction column filling device is small, and the accuracy of a processing result is high.
In order to solve the problems, the following technical scheme is provided:
the solid phase extraction column filling device is characterized by comprising a horizontally arranged bottom plate, wherein a bracket is arranged on the bottom plate; the support is provided with a vertically arranged driving cylinder, the driving cylinder is connected with a driving system, a piston rod of the driving cylinder faces downwards, and a cylindrical pressure head is concentrically arranged at the lower end of the piston rod of the driving cylinder. A limiting block is arranged on the bottom plate below the columnar pressure head, a clamping hole is formed in the top of the limiting block, and the clamping hole and the columnar pressure head are arranged concentrically.
The air pump is characterized in that the driving cylinder is an air cylinder, the driving system comprises an air pump, a switch, a pressure regulating valve and a pressure gauge, the switch is provided with a first interface, a second interface and a third interface, and the pressure regulating valve is provided with a first air outlet, a second air outlet, an air inlet and a pressure regulating handle. The first interface of the switch is connected with the rod cavity of the driving cylinder, the second interface of the switch is connected with the rodless cavity of the driving cylinder, the first air outlet of the pressure regulating valve is connected with the third interface of the switch, the second air outlet of the pressure regulating valve is connected with the pressure gauge, and the air pump is connected with the air inlet of the pressure regulating valve.
The switch is a foot switch.
The support comprises a vertically-arranged support plate, a vertically-arranged connecting plate is fixed to the upper portion of one side of the support plate, the connecting plate is parallel to the support plate, bent portions which are bent by 90 degrees and are far away from one side of the support plate are arranged at the upper side and the lower side of the connecting plate, and the driving cylinder is fixed between the two bent portions.
By adopting the scheme, the method has the following advantages:
the solid phase extraction column filling device comprises a bottom plate, a support is arranged on the bottom plate, a driving cylinder is arranged on the support and connected with a driving system, a piston rod of the driving cylinder faces downwards, a columnar pressure head is arranged at the lower end of the piston rod of the driving cylinder, a limiting block is arranged on the bottom plate below the columnar pressure head, and a clamping hole is formed in the top of the limiting block. When in use, the pressure of the driving system is set; then, the column tube filled with the filler is placed in the clamping hole; then, a piston rod of the driving cylinder is driven to descend by the driving system, and the columnar pressure head enters the column tube to compress the filler; and then, a piston rod of the driving cylinder is driven to move upwards through the driving system, so that the columnar pressure head leaves the column tube. Thereafter, the screen plate is loaded into the column tube. And then, driving a piston rod of the driving cylinder to extend out through the driving system again, so that the shape pressure head descends, and the sieve plate is tightly pressed on the filler. And finally, the piston rod of the columnar pressure head ascends, and the column tube is taken down. The solid-phase extraction column filling device utilizes the driving system to drive the driving cylinder to compress the filler, and the pressure of the driving system is set, so that the pressure for compressing each time can be ensured to be consistent, the density of the filler filled in the column tube is consistent, the prepared solid-phase extraction column is ensured to have almost no difference, the error of sample pretreatment is greatly reduced, and the accuracy of a processing result is higher.
Drawings
FIG. 1 is a schematic view showing the structure of a packing device for a solid phase extraction column according to the present invention;
FIG. 2 is a control schematic of the drive cylinder and drive system of the solid phase extraction column apparatus packing of the present invention.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings.
As shown in FIGS. 1 and 2, the solid phase extraction column packing apparatus of the present invention comprises a horizontally arranged bottom plate 1, and a support is provided on the bottom plate 1. The support is provided with a vertically arranged driving cylinder 5, the driving cylinder 5 is connected with a driving system, a piston rod of the driving cylinder 5 faces downwards, and the lower end of the piston rod of the driving cylinder 5 is concentrically provided with a columnar pressure head 4. A limiting block 2 is arranged on the bottom plate 1 below the columnar pressure head 4, a clamping hole 3 is formed in the top of the limiting block 2, and the clamping hole 3 and the columnar pressure head 4 are concentrically arranged.
The actuating cylinder 5 is the cylinder, actuating system includes air pump 9, switch 11, pressure-regulating valve 10 and manometer 12, switch 11 has first interface A1, second interface A2 and third interface A3, pressure-regulating valve 10 has first gas outlet B1, second gas outlet B2, air inlet C and pressure regulating handle. The first port A1 of the switch 11 is connected with a rod cavity of the driving cylinder 5, the second port A2 of the switch 11 is connected with a rodless cavity of the driving cylinder 5, the first air outlet B1 of the pressure regulating valve 10 is connected with the third port A3 of the switch 11, the second air outlet B2 of the pressure regulating valve 10 is connected with the pressure gauge 12, and the air pump 9 is connected with the air inlet C of the pressure regulating valve 10. The switch 11 is a foot switch 11.
The support includes vertical arrangement's backup pad 8, and the upper portion of this backup pad 8 one side is fixed with vertical arrangement's connecting plate 7, and connecting plate 7 is parallel with backup pad 8, and the higher authority and the lower level of connecting plate 7 all have to be the kink 6 that is 90 degrees crooked keeping away from backup pad 8 one side, the driving cylinder 5 is fixed between two kinks 6.
When in use, the pressure of the driving system is set; then, the column tube filled with the filler is placed in the clamping hole 3; then, a piston rod of a driving cylinder 5 is driven to descend by a driving system, and a columnar pressure head 4 enters a column tube to compress the filler; and then, driving a piston rod of the driving cylinder 5 to move upwards through a driving system, so that the columnar pressure head 4 leaves the column tube. Thereafter, the screen plate is loaded into the column tube. And then, the driving system drives the piston rod of the driving cylinder 5 to extend out again, so that the shape pressure head descends to press the sieve plate on the filler. And finally, the piston rod of the columnar pressure head 4 moves upwards, and the column tube is taken down.
Claims (4)
1. A solid phase extraction column packing device is characterized by comprising a horizontally arranged bottom plate (1), wherein a bracket is arranged on the bottom plate (1); a driving cylinder (5) is vertically arranged on the support, the driving cylinder (5) is connected with a driving system, a piston rod of the driving cylinder (5) faces downwards, and a cylindrical pressure head (4) is concentrically arranged at the lower end of the piston rod of the driving cylinder (5); a limiting block (2) is arranged on the bottom plate (1) below the columnar pressure head (4), a clamping hole (3) is formed in the top of the limiting block (2), and the clamping hole (3) and the columnar pressure head (4) are concentrically arranged.
2. The solid phase extraction column packing apparatus of claim 1, wherein the driving cylinder (5) is a pneumatic cylinder, the driving system comprises an air pump (9), a switch (11), a pressure regulating valve (10) and a pressure gauge (12), the switch (11) has a first port (a 1), a second port (a 2) and a third port (A3), the pressure regulating valve (10) has a first outlet (B1), a second outlet (B2), an inlet (C) and a pressure regulating handle; the first interface (A1) of the switch (11) is connected with a rod cavity of the driving cylinder (5), the second interface (A2) of the switch (11) is connected with a rodless cavity of the driving cylinder (5), the first air outlet (B1) of the pressure regulating valve (10) is connected with the third interface (A3) of the switch (11), the second air outlet (B2) of the pressure regulating valve (10) is connected with the pressure gauge (12), and the air pump (9) is connected with the air inlet (C) of the pressure regulating valve (10).
3. The solid phase extraction column packing apparatus of claim 2, wherein the switch (11) is a foot switch (11).
4. The solid phase extraction column packing apparatus according to any one of claims 1 to 3, characterized in that the support comprises a vertically arranged support plate (8), a vertically arranged connecting plate (7) is fixed on the upper portion of one side of the support plate (8), the connecting plate (7) is parallel to the support plate (8), the upper and lower edges of the connecting plate (7) have bent portions (6) which are bent at an angle of 90 ° away from the support plate (8), and the driving cylinder (5) is fixed between the two bent portions (6).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010234665.4A CN111282313A (en) | 2020-03-30 | 2020-03-30 | Solid phase extraction column filling device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010234665.4A CN111282313A (en) | 2020-03-30 | 2020-03-30 | Solid phase extraction column filling device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111282313A true CN111282313A (en) | 2020-06-16 |
Family
ID=71018574
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010234665.4A Pending CN111282313A (en) | 2020-03-30 | 2020-03-30 | Solid phase extraction column filling device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111282313A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112091120A (en) * | 2020-10-09 | 2020-12-18 | 内蒙古上海庙矿业有限责任公司 | Steel bar bender |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN203525370U (en) * | 2013-11-06 | 2014-04-09 | 北京英智达科技有限公司 | Filler filling structure for chromatographic column |
| CN203634860U (en) * | 2014-01-14 | 2014-06-11 | 河南科技学院 | Solid-phase extraction column filling device |
| CN204135550U (en) * | 2014-08-20 | 2015-02-04 | 四川左军机械制造有限公司 | For welding the high frequency induction welding connection device of fuel tank nut |
| CN205461132U (en) * | 2016-03-24 | 2016-08-17 | 深圳逗点生物技术有限公司 | Solid -phase extraction post assembly machine |
| CN212236078U (en) * | 2020-03-30 | 2020-12-29 | 无锡加莱克色谱科技有限公司 | Solid phase extraction column filling device |
-
2020
- 2020-03-30 CN CN202010234665.4A patent/CN111282313A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN203525370U (en) * | 2013-11-06 | 2014-04-09 | 北京英智达科技有限公司 | Filler filling structure for chromatographic column |
| CN203634860U (en) * | 2014-01-14 | 2014-06-11 | 河南科技学院 | Solid-phase extraction column filling device |
| CN204135550U (en) * | 2014-08-20 | 2015-02-04 | 四川左军机械制造有限公司 | For welding the high frequency induction welding connection device of fuel tank nut |
| CN205461132U (en) * | 2016-03-24 | 2016-08-17 | 深圳逗点生物技术有限公司 | Solid -phase extraction post assembly machine |
| CN212236078U (en) * | 2020-03-30 | 2020-12-29 | 无锡加莱克色谱科技有限公司 | Solid phase extraction column filling device |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112091120A (en) * | 2020-10-09 | 2020-12-18 | 内蒙古上海庙矿业有限责任公司 | Steel bar bender |
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