CN111281613A - 3D printing-based bionic porous artificial vertebral body preparation method - Google Patents
3D printing-based bionic porous artificial vertebral body preparation method Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/442—Intervertebral or spinal discs, e.g. resilient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30772—Apertures or holes, e.g. of circular cross section
- A61F2002/30784—Plurality of holes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
- A61F2002/30948—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using computerized tomography, i.e. CT scans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2002/30985—Designing or manufacturing processes using three dimensional printing [3DP]
Abstract
The invention provides a preparation method of a bionic porous artificial vertebral body based on 3D printing, which comprises the following steps: 1. constructing a finite element model of the spine; 2. carrying out a simulation biomechanics experiment on the constructed finite element model; 3. adjusting the size or position of the artificial vertebral body according to the stress distribution borne by the artificial vertebral body to obtain an artificial vertebral body model which best meets the spinal biomechanics; 4. and 3D printing technology is utilized, the PEEK material is used for printing the artificial vertebral body model designed in the step 3, and the surface of the artificial vertebral body, which is in contact with the upper vertebral body and the lower vertebral body, is printed into a porous structure which is beneficial to bone ingrowth. The stress distribution borne by the artificial vertebral body is analyzed, so that the artificial vertebral body meets the biomechanical requirements of the spine, and the fusion, reliability and stability of use are ensured; the high-performance polymer material Polyetheretherketone (PEEK) is adopted for 3D printing, the biomechanical matching performance is good, the imaging examination is not interfered, the personalized customization is realized, and the biomechanical requirements are met.
Description
Technical Field
The invention relates to the technical field of spinal vertebral body reconstruction, in particular to a preparation method of a bionic porous artificial vertebral body based on 3D printing.
Background
At present, in spinal surgery, for patients with spine diseases who need to remove vertebral bodies, most of filling the defective vertebral bodies are titanium alloy titanium cages and autogenous bones or allogenic bones, but allogenic bones or autogenous bones are required to be filled conventionally to realize osseous fusion in the later stage, the allogenic bones are expensive, rejection reaction can occur, the autogenous bones need secondary operation to take iliac bones, and problems such as wound complications, sequelae and the like can be caused. Even if the artificial vertebral body for 3D printing is mostly made of metal materials such as titanium alloy, the metal materials have the problems of mismatching of elastic modulus, stress shielding, interference on imaging examination and the like.
The patent application No. 201710995804.3 discloses a 3D printed personalized customized artificial vertebral body and a method of making the same. The method establishes a three-dimensional model for CT scanning before the operation of the defected vertebral body, prints out the 3D porous bionic individualized vertebral body through optimized design, and improves the biocompatibility of the vertebral body through bioactive treatment. However, no simulation biomechanical experiment is performed after the three-dimensional model is established, and no combination of solid mechanics detection and biomechanical analysis is performed, so that the printed vertebral body can not well meet the spinal biomechanical requirements.
Disclosure of Invention
Technical problem to be solved
The invention aims to provide a preparation method of a bionic porous artificial vertebral body based on 3D printing, which aims to solve the problems that the existing preparation method of the 3D printing artificial vertebral body does not carry out a simulation biomechanical experiment and does not combine physical mechanics detection with biomechanical analysis, so that the printed vertebral body can not well meet the spinal biomechanical requirements.
(II) technical scheme
In order to solve the problems that the existing 3D printing artificial vertebral body preparation method does not carry out a simulation biomechanical experiment and does not combine physical mechanics detection with biomechanical analysis, so that the printed vertebral body cannot well meet the spinal biomechanical requirement, the invention provides the following technical scheme:
a preparation method of a bionic porous artificial vertebral body based on 3D printing comprises the following steps:
step 1, acquiring spine CT data of a patient, establishing a three-dimensional digital model of the spine by using a finite element analysis method, carrying out gridding on the generated three-dimensional digital model to obtain a gridded geometric model, and combining the gridded geometric model with an anatomical structure of the spine to construct a finite element model of the spine;
step 2, carrying out a simulation biomechanics experiment on the constructed finite element model, analyzing data of the spine model in normal compressive stress, rotational stress, bending stress and lateral bending stress states, and analyzing stress conditions of the vertebral body and the intervertebral disc;
step 3, designing an artificial vertebral body according to the defect range of the spine after the vertebral body is removed, simulating a preset operation mode, completing a spine reconstruction operation, analyzing the data of the spine operation model under the states of normal pressure stress, rotation stress, bending stress and lateral bending stress, analyzing the stress conditions of the vertebral body and intervertebral disc, comparing the stress conditions with preoperative data, and adjusting the size or the position of the artificial vertebral body according to the stress distribution born by the artificial vertebral body to obtain the artificial vertebral body model which best accords with the spinal biomechanics;
and 4, printing the artificial vertebral body model designed in the step 3 by using a PEEK material by using a 3D printing technology, and printing the contact surface of the artificial vertebral body and the upper and lower vertebral bodies into a porous structure favorable for bone ingrowth.
Preferably, the step 1 adopts mimics software to establish a three-dimensional digital model of the spine.
Preferably, hypermesh software is applied in step 1 to perform gridding on the generated three-dimensional digital model of the spine.
Preferably, the finite element model constructed in step 2 is introduced into Ansys software to perform a simulation biomechanical experiment.
Preferably, in the step 2, stress conditions of the vertebral body and the intervertebral disc are analyzed through a Von Mises cloud picture.
Preferably, the artificial vertebral body model designed in the step 3 has a compressive stiffness of more than 6200N/mm, a compressive stiffness yield load of more than 7000N and a fatigue compressive load of 5200N.
Preferably, the pore size of the porous structure in step 4 is: 600 +/-200 um, porous structure silk diameter: 600 +/-200 um, porosity of porous structure: 50 to 80 percent.
(III) advantageous effects
Compared with the prior art, the invention provides a preparation method of a bionic porous artificial vertebral body based on 3D printing, which has the following beneficial effects: according to the method, data of the spine model in the states of normal compressive stress, rotational stress, bending stress and lateral bending stress and stress conditions of the vertebral bodies and intervertebral discs are analyzed before the artificial vertebral bodies are printed, so that the artificial vertebral bodies meet the biomechanical requirements of the spine, and compared with the artificial vertebral bodies manufactured by the traditional means, the compressive rigidity yield load and the fatigue compressive load of the artificial vertebral bodies are greatly improved; the high-performance polymer material Polyetheretherketone (PEEK) is adopted for 3D printing, the biomechanical matching is good, no interference is caused to imaging examination, and the customized printing is personalized and meets the biomechanical requirements; the porous structure which is most beneficial to cell adhesion and new bone growth is printed out according to 3D, and the later period osseous fusion can be completed without secondary bone grafting.
Drawings
FIG. 1 is a schematic diagram of a lumbar finite element model according to an embodiment of the present invention;
FIG. 2 is a schematic view of an artificial vertebral body according to an embodiment of the present invention;
fig. 3 is a 3D printed artificial vertebral body object diagram in the embodiment of the invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention provides a preparation method of a bionic porous artificial vertebral body based on 3D printing, which comprises the following steps:
step 1, aiming at a patient suffering from spinal tumor or tuberculosis and needing to remove a vertebral body or accompanied with large-area spinal defect, obtaining spinal CT data of the patient, establishing a three-dimensional digital model of the spinal by using a finite element analysis method and using Mimics software, and gridding the model generated by the Mimics by using hypermesh software to obtain a geometric model. And (3) introducing the gridded geometric model by using general finite element pretreatment software, and constructing a finite element model of the spine according to the anatomical structure of the spine, wherein the finite element model is a lumbar vertebra finite element model as shown in figure 1.
And 2, importing the constructed finite element model into Ansys software to carry out a simulation biomechanical experiment, analyzing data of the spine model in normal compressive stress, rotational stress, bending stress and stretching stress and lateral bending stress states, and analyzing stress conditions of the vertebral body and the intervertebral disc through a Von Mises cloud picture.
Step 3, designing an artificial vertebral body according to the range of the spine defect after the vertebral body resection, as shown in figure 2; the initial size design is shown in table 1, a preset operation mode is simulated, the spine reconstruction operation is completed, the data of the spine operation model in the states of normal compressive stress, rotational stress, bending stress and lateral bending stress are analyzed again, the stress conditions of the vertebral body and the intervertebral disc are analyzed through a Von Mises cloud picture, the stress conditions are compared with preoperative data, and the size or the position of the artificial vertebral body is properly adjusted according to the stress distribution born by the artificial vertebral body. By utilizing the analysis, the artificial vertebral body model which best accords with the spinal biomechanics can be obtained. In the artificial vertebral body model designed here, static load is applied to the artificial vertebral body, and the compressive stiffness of the artificial vertebral body is more than 6200N/mm; the compressive stiffness yield load of the artificial vertebral body is more than 7000N; the fatigue compression load of the artificial vertebral body is 5200N. Compared with an artificial vertebral body model manufactured by the traditional means, the compressive stiffness yield load and the fatigue compressive load of the artificial vertebral body model are greatly improved.
TABLE 1 basic dimensions and ultimate deviation in millimeters
Step 4, according to the analysis result of the operation model, the personalized customization of the artificial vertebral body can be realized, and the optimal matching of biomechanics is realized; utilize 3D printing technique, use the PEEK material to print the artifical centrum of above-mentioned design, the PEEK material that uses here should accord with the performance requirement in table 2, prints artifical centrum and the surface of upper and lower centrum contact into the porous structure that is favorable to the bone to grow into, realizes need not to plant the bone once more, can accomplish the bony fusion in later stage, as shown in fig. 3. Pore size of the porous structure designed here, pore size of the porous structure: 600 +/-200 um, porous structure silk diameter: 600 +/-200 um, porosity of porous structure: 50 to 80 percent.
TABLE 2 PEEK Material Performance requirements
In conclusion, the method analyzes the data of the spine model under the states of normal pressure stress, rotation stress, bending stress and lateral bending stress and the stress conditions of the vertebral bodies and the intervertebral discs before printing the artificial vertebral bodies, so that the artificial vertebral bodies meet the biomechanical requirements of the spine, and the fusion property, reliability and stability of use are ensured; the high-performance polymer material Polyetheretherketone (PEEK) is adopted for 3D printing, the biomechanical matching is good, no interference is caused to imaging examination, and the customized printing is personalized and meets the biomechanical requirements; the porous structure which is most beneficial to cell adhesion and new bone growth is printed out according to 3D, and the later period osseous fusion can be completed without secondary bone grafting.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (7)
1. A preparation method of a bionic porous artificial vertebral body based on 3D printing is characterized by comprising the following steps:
step 1, acquiring spine CT data of a patient, establishing a three-dimensional digital model of the spine by using a finite element analysis method, carrying out gridding on the generated three-dimensional digital model to obtain a gridded geometric model, and combining the gridded geometric model with an anatomical structure of the spine to construct a finite element model of the spine;
step 2, carrying out a simulation biomechanics experiment on the constructed finite element model, analyzing data of the spine model in normal compressive stress, rotational stress, bending stress and lateral bending stress states, and analyzing stress conditions of the vertebral body and the intervertebral disc;
step 3, designing an artificial vertebral body according to the defect range of the spine after the vertebral body is removed, simulating a preset operation mode, completing a spine reconstruction operation, analyzing the data of the spine operation model under the states of normal pressure stress, rotation stress, bending stress and lateral bending stress, analyzing the stress conditions of the vertebral body and intervertebral disc, comparing the stress conditions with preoperative data, and adjusting the size or the position of the artificial vertebral body according to the stress distribution born by the artificial vertebral body to obtain the artificial vertebral body model which best accords with the spinal biomechanics;
and 4, printing the artificial vertebral body model designed in the step 3 by using a PEEK material by using a 3D printing technology, and printing the contact surface of the artificial vertebral body and the upper and lower vertebral bodies into a porous structure favorable for bone ingrowth.
2. The preparation method of the bionic porous artificial vertebral body based on 3D printing as claimed in claim 1, characterized in that: in the step 1, a three-dimensional digital model of the spine is established by adopting mimics software.
3. The preparation method of the bionic porous artificial vertebral body based on 3D printing as claimed in claim 1, characterized in that: and step 1, gridding the generated three-dimensional digital model of the spine by using hypermesh software.
4. The preparation method of the bionic porous artificial vertebral body based on 3D printing as claimed in claim 1, characterized in that: and (3) importing the constructed finite element model into Ansys software to carry out a simulation biomechanical experiment.
5. The preparation method of the bionic porous artificial vertebral body based on 3D printing as claimed in claim 1, characterized in that: and in the step 2, stress conditions of the vertebral body and the intervertebral disc are analyzed through a Von Mises cloud picture.
6. The preparation method of the bionic porous artificial vertebral body based on 3D printing as claimed in claim 1, characterized in that: the artificial vertebral body model designed in the step 3 has the compression rigidity of the artificial vertebral body larger than 6200N/mm, the compression rigidity yield load of the artificial vertebral body larger than 7000N, and the fatigue compression load of the artificial vertebral body 5200N.
7. The preparation method of the bionic porous artificial vertebral body based on 3D printing as claimed in claim 1, characterized in that: pore diameter of the porous structure in the step 4: 600 +/-200 um, porous structure silk diameter: 600 +/-200 um, porosity of porous structure: 50 to 80 percent.
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