CN112155805A - 3D printing bionic porous zero-shear-recording anterior cervical interbody fusion cage and preparation method thereof - Google Patents
3D printing bionic porous zero-shear-recording anterior cervical interbody fusion cage and preparation method thereof Download PDFInfo
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- CN112155805A CN112155805A CN202010906879.1A CN202010906879A CN112155805A CN 112155805 A CN112155805 A CN 112155805A CN 202010906879 A CN202010906879 A CN 202010906879A CN 112155805 A CN112155805 A CN 112155805A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
- A61F2/446—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages having a circular or elliptical cross-section substantially parallel to the axis of the spine, e.g. cylinders or frustocones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
- A61F2002/30943—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using mathematical models
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
- A61F2002/30948—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using computerized tomography, i.e. CT scans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2002/30985—Designing or manufacturing processes using three dimensional printing [3DP]
Abstract
The invention discloses a 3D printing bionic porous zero-shear-recording anterior cervical interbody fusion cage which comprises a 3D printing PEEK interbody fusion cage body, wherein the 3D printing PEEK interbody fusion cage body comprises a 3D printing solid part, a developing rod and a 3D printing hollow grid part. According to the invention, by utilizing a 3D printing technology, a high-performance polymer material polyether-ether-ketone is used for printing the model of the interbody fusion cage, the central part of the interbody fusion cage is printed into a porous structure which is beneficial to bone ingrowth, so that the interbody fusion cage meets the spinal biomechanical requirements, has good biomechanical matching property, is free of interference on imaging examination, is customized individually, meets the biomechanical requirements, is convenient to combine and fix with a 3D printed titanium alloy zero-notch fixing component, is used for simulating a biomechanical experiment by arranging a finite element model, and is adjusted in size or position according to stress distribution born by the interbody fusion cage, thus obtaining the interbody fusion cage model which best meets the spinal biomechanics.
Description
Technical Field
The invention relates to the technical field of vertebral column vertebral body reconstruction, in particular to a 3D printing bionic porous zero-shear-mark cervical anterior intervertebral fusion cage and a preparation method thereof.
Background
The intervertebral fusion has the functions of supporting, load sharing and the like, can better recover the intervertebral space height and physiological curvature of cervical vertebra, the intervertebral fusion device is implanted between an upper vertebral body and a lower vertebral body after a pathological intervertebral disc is removed in the operation, the sequence and the stability of the vertebral column can be recovered after the upper vertebral body and the lower vertebral body are combined in a bone manner, and various types of intervertebral fusion devices are successively appeared since the intervertebral fusion device is successfully used for the intervertebral fusion and are widely applied clinically.
The material of the cervical vertebra anterior intervertebral fusion device product which is most commonly used clinically at present is PEEK, the PEEK has the advantages of excellent biocompatibility, chemical stability, wear resistance and the like, and is close to the Young modulus of human bone, so that the stress shielding and loosening phenomena generated by the implanted cervical vertebra anterior intervertebral fusion device product and adjacent vertebral bone can be effectively avoided; PEEK has good material tracing ability, can penetrate X-ray, facilitate the postoperative X-ray observation to fuse the situation; the PEEK has small MRI artifact, and is convenient for postoperative evaluation of spinal nerve function.
Although the existing PEEK material interbody fusion cage obtains good clinical curative effect, the PEEK material is difficult to form osseous combination with new bones, and the problems of loosening and displacement at the later stage of implantation are easily caused; the traditional forming process can not modify the material in the forming process so as to improve the biological performance of the material; the PEEK surface is sprayed with materials with osteoinductive activity, such as hydroxyapatite and the like, the problem that the surface coating is easy to fall off in the implantation process and the like is solved.
The cervical spine anterior Zero-notch interbody fusion cage is widely applied to regions such as Europe and America and Asia, however, currently, the number of products of the self-designed cervical spine anterior Zero-notch interbody fusion cage authorized in China is small, and 3D printing of the bionic porous Zero-notch interbody fusion cage is not reported.
Disclosure of Invention
The invention aims to provide a 3D printing bionic porous zero-shear-memory anterior cervical interbody fusion cage and a preparation method thereof, and aims to solve the problem of insufficient clinical application of the traditional interbody fusion cage in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme: the utility model provides a 3D prints bionical porous zero-shear note anterior cervical spine interbody fusion cage, prints PEEK interbody fusion cage body including 3D, 3D prints PEEK interbody fusion cage body and includes that 3D prints solid portion, development bar and 3D and prints cavity net portion, 3D prints the left side swing joint of PEEK interbody fusion cage body and has 3D to print titanium alloy fixing device, 3D prints titanium alloy fixing device and includes the fixed block, pushes up the piece, pushes down the piece and fixed buckle, the surface that pushes up the piece and push down the piece all with fixed buckle fixed connection, the inner wall of fixed block respectively with push up the piece and push down a swing joint, the surface and the 3D of fixed buckle print solid portion swing joint.
Preferably, the inside of the push-up piece and the inside of the push-down piece are both provided with threaded holes.
Preferably, the surfaces of the upward pushing piece and the downward pushing piece are both provided with two screw holes.
Preferably, the top and the bottom that 3D printed PEEK interbody fusion cage body all are the slope setting, and 3D printed PEEK interbody fusion cage body's top and bottom inclination angle sum is 4.
Preferably, the 3D printing hollow grid part is matched with the 3D printing solid part.
Preferably, the number of the fixing buckles is two.
A preparation method of a 3D printing bionic porous zero-shear-mark anterior cervical interbody fusion cage comprises the following steps
S1: acquiring cervical vertebra CT data of a patient, constructing a three-dimensional digital model of the cervical vertebra by using a finite element analysis method, gridding the generated three-dimensional digital model to obtain a gridded geometric model, and constructing a cervical vertebra finite element model by combining the gridded geometric model with an anatomical structure of the cervical vertebra;
s2: carrying out a simulation biomechanics experiment on the constructed cervical vertebra finite element model, analyzing data of the cervical vertebra finite element model in normal compressive stress, rotational stress, bending stress and lateral bending stress states, and analyzing the stress condition of the interbody fusion cage;
s3: designing an intervertebral fusion cage according to the height of an intervertebral space after discectomy, simulating a preset operation mode, completing a cervical vertebra reconstruction operation, analyzing data of an anterior cervical vertebra operation model in normal pressure stress, rotation stress, flexion and extension stress and lateral bending stress states again, analyzing the stress condition of the intervertebral fusion cage, comparing the stress condition with preoperative data, and adjusting the size or the position of the intervertebral fusion cage according to the stress distribution born by the intervertebral fusion cage to obtain the intervertebral fusion cage model which best meets the biomechanics of the cervical vertebra;
s4: printing an intervertebral cage model designed in S3 by using a PEEK material by using a 3D printing technology, and printing the central part of the intervertebral cage into a porous structure beneficial to bone ingrowth;
s5: and (3) printing the titanium alloy zero-shear mark fixing component by using a titanium alloy material by using a 3D printing technology.
Compared with the prior art, the invention has the following beneficial effects:
1. according to the invention, by utilizing a 3D printing technology, the high-performance polymer material polyether-ether-ketone is used for printing the model of the interbody fusion cage, and the central part of the interbody fusion cage is printed into a porous structure which is beneficial to bone ingrowth, so that the interbody fusion cage meets the spinal biomechanical requirements, has good biomechanical matching property, is free of interference on imaging examination, is customized individually, meets the biomechanical requirements, and is convenient for combination and fixation with a 3D printed titanium alloy zero-shear fixation component.
2. The preparation method of the invention carries out simulation biomechanical experiment by arranging the finite element model, and adjusts the size or the position of the interbody fusion cage according to the stress distribution born by the interbody fusion cage, thereby obtaining the interbody fusion cage model which best meets the spinal biomechanics.
Drawings
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a bottom sectional view of the structure of the present invention;
fig. 3 is a partial left side view of the structure of the present invention.
In the figure: 1. 3D printing a PEEK interbody fusion cage body; 11. a developing rod; 12. 3D printing a hollow grid part; 13. 3D printing a solid part; 2. 3D printing a titanium alloy fixing device; 21. a fixed block; 22. pushing up the piece; 23. fixing the buckle; 24. pushing down the piece; 25. a threaded hole; 26. screw holes.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-3, a 3D printing bionic porous zero-shear memory cervical anterior interbody fusion cage comprises a 3D printing PEEK interbody fusion cage body 1, the 3D printing PEEK interbody fusion cage body 1 comprises a 3D printing solid part 13, a developing rod 11 and a 3D printing hollow grid part 12, the 3D printing hollow grid part 12 is adapted to the 3D printing solid part 13, the left side of the 3D printing PEEK interbody fusion cage body 1 is movably connected with a 3D printing titanium alloy fixing device 2, the 3D printing titanium alloy fixing device 2 comprises a fixing block 21, an upward pushing part 22, a downward pushing part 24 and fixing buckles 23, the number of the fixing buckles 23 is two, the surfaces of the upward pushing part 22 and the downward pushing part 24 are fixedly connected with the fixing buckles 23, the inner walls of the fixing block 21 are respectively movably connected with the upward pushing part 22 and the downward pushing part 24, the surface of the fixing buckles 23 is movably connected with the 3D printing solid part 13, the inside of the push-up piece 22 and the push-down piece 24 is all provided with threaded holes 25, the number of the screw holes 25 is two, the center of the right front of the 3D printing titanium alloy fixing device 2 is provided with a threaded hole 26, the top and the bottom of the 3D printing PEEK interbody fusion cage body 1 are obliquely arranged, the total inclination angle of the top and the bottom of the 3D printing PEEK interbody fusion cage body 1 is 4 degrees, by utilizing the 3D printing technology, a high-performance polymer material PEEK is used for printing an interbody fusion cage model, the central part of the interbody fusion cage is printed into a porous structure beneficial to bone ingrowth, so that the interbody fusion cage meets the spinal biomechanical requirements, the biomechanical matching performance is good, the imaging examination is free of interference, the customized and meets the biomechanical requirements, and the combined fixation with the 3D printing titanium alloy zero-notch fixing component is convenient.
A preparation method of a 3D printing bionic porous zero-shear-mark anterior cervical interbody fusion cage comprises the following steps of S1: acquiring cervical vertebra CT data of a patient, constructing a three-dimensional digital model of the cervical vertebra by using a finite element analysis method, gridding the generated three-dimensional digital model to obtain a gridded geometric model, and constructing a cervical vertebra finite element model by combining the gridded geometric model with an anatomical structure of the cervical vertebra; s2: carrying out a simulation biomechanics experiment on the constructed cervical vertebra finite element model, analyzing data of the cervical vertebra finite element model in normal compressive stress, rotational stress, bending stress and lateral bending stress states, and analyzing the stress condition of the interbody fusion cage; s3: designing an intervertebral fusion cage according to the height of an intervertebral space after discectomy, simulating a preset operation mode, completing a cervical vertebra reconstruction operation, analyzing data of an anterior cervical vertebra operation model in normal pressure stress, rotation stress, flexion and extension stress and lateral bending stress states again, analyzing the stress condition of the intervertebral fusion cage, comparing the stress condition with preoperative data, and adjusting the size or the position of the intervertebral fusion cage according to the stress distribution born by the intervertebral fusion cage to obtain the intervertebral fusion cage model which best meets the biomechanics of the cervical vertebra; s4: printing an intervertebral cage model designed in S3 by using a PEEK material by using a 3D printing technology, and printing the central part of the intervertebral cage into a porous structure beneficial to bone ingrowth; s5: the method comprises the steps of utilizing a 3D printing technology, printing a titanium alloy zero-shear-mark fixing assembly by using a titanium alloy material, carrying out a biomechanics simulation experiment by setting a finite element model, and adjusting the size or the position of the interbody fusion cage according to stress distribution born by the interbody fusion cage to obtain the interbody fusion cage model most conforming to spinal biomechanics.
The bionic porous anterior cervical interbody fusion cage integrally formed through 3D printing and preparation can simplify operation steps in the operation, bone materials do not need to be filled in the interbody fusion cage in the operation, and the bionic porous intervertebral fusion cage is favorable for vertebral body bone growth and can obtain better clinical curative effect.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (7)
1. The utility model provides a 3D prints bionical porous zero surely note anterior cervical spine interbody fusion cage, includes that 3D prints PEEK interbody fusion cage body (1), its characterized in that: 3D prints PEEK interbody fusion cage body (1) and prints cavity net portion (12) including 3D printing solid portion (13), development rod (11) and 3D, the left side swing joint that 3D printed PEEK interbody fusion cage body (1) has 3D to print titanium alloy fixing device (2), 3D prints titanium alloy fixing device (2) including fixed block (21), push up piece (22), push down piece (24) and fixed buckle (23), the surface that pushes up piece (22) and push down piece (24) all with fixed buckle (23) fixed connection, the inner wall of fixed block (21) respectively with push up piece (22) and push down piece (24) swing joint, the surface and the 3D of fixed buckle (23) print solid portion (13) swing joint.
2. The 3D printing bionic porous zero-shear-mark anterior cervical interbody fusion cage of claim 1, wherein the bionic porous zero-shear-mark anterior cervical interbody fusion cage comprises: threaded holes (25) are formed in the upper pushing piece (22) and the lower pushing piece (24).
3. The 3D printing bionic porous zero-shear-mark anterior cervical interbody fusion cage of claim 1, wherein the bionic porous zero-shear-mark anterior cervical interbody fusion cage comprises: screw holes (26) are formed in the surfaces of the upward pushing piece (22) and the downward pushing piece (24), and the number of the screw holes (26) is two.
4. The 3D printing bionic porous zero-shear-mark anterior cervical interbody fusion cage of claim 1, wherein the bionic porous zero-shear-mark anterior cervical interbody fusion cage comprises: the top and the bottom that 3D printed PEEK interbody fusion cage body (1) all are the slope setting, and 3D printed PEEK interbody fusion cage body's (1) top and the inclination angle sum of bottom be 4.
5. The 3D printing bionic porous zero-shear-mark anterior cervical interbody fusion cage of claim 1, wherein the bionic porous zero-shear-mark anterior cervical interbody fusion cage comprises: the 3D printing hollow grid part (12) is matched with the 3D printing solid part (13).
6. The 3D printing bionic porous zero-shear-mark anterior cervical interbody fusion cage of claim 1, wherein the bionic porous zero-shear-mark anterior cervical interbody fusion cage comprises: the number of the fixing buckles (23) is two.
7. A preparation method of a 3D printing bionic porous zero-shear-mark anterior cervical interbody fusion cage is characterized by comprising the following steps: comprises the following steps
S1: acquiring cervical vertebra CT data of a patient, constructing a three-dimensional digital model of the cervical vertebra by using a finite element analysis method, gridding the generated three-dimensional digital model to obtain a gridded geometric model, and constructing a cervical vertebra finite element model by combining the gridded geometric model with an anatomical structure of the cervical vertebra;
s2: carrying out a simulation biomechanics experiment on the constructed cervical vertebra finite element model, analyzing data of the cervical vertebra finite element model in normal compressive stress, rotational stress, bending stress and lateral bending stress states, and analyzing the stress condition of the interbody fusion cage;
s3: designing an intervertebral fusion cage according to the height of an intervertebral space after discectomy, simulating a preset operation mode, completing a cervical vertebra reconstruction operation, analyzing data of an anterior cervical vertebra operation model in normal pressure stress, rotation stress, flexion and extension stress and lateral bending stress states again, analyzing the stress condition of the intervertebral fusion cage, comparing the stress condition with preoperative data, and adjusting the size or the position of the intervertebral fusion cage according to the stress distribution born by the intervertebral fusion cage to obtain the intervertebral fusion cage model which best meets the biomechanics of the cervical vertebra;
s4: printing an intervertebral cage model designed in S3 by using a PEEK material by using a 3D printing technology, and printing the central part of the intervertebral cage into a porous structure beneficial to bone ingrowth;
s5: and (3) printing the titanium alloy zero-shear mark fixing component by using a titanium alloy material by using a 3D printing technology.
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| CN202010906879.1A CN112155805A (en) | 2020-09-01 | 2020-09-01 | 3D printing bionic porous zero-shear-recording anterior cervical interbody fusion cage and preparation method thereof |
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| CN202010906879.1A CN112155805A (en) | 2020-09-01 | 2020-09-01 | 3D printing bionic porous zero-shear-recording anterior cervical interbody fusion cage and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113040981A (en) * | 2021-02-08 | 2021-06-29 | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | Polyether-ether-ketone artificial vertebral body |
| CN113317860A (en) * | 2021-06-22 | 2021-08-31 | 深圳市艾科赛龙科技股份有限公司 | Prosthesis fixing structure for mandible restoration and three-dimensional model design method |
| CN116919679A (en) * | 2023-09-18 | 2023-10-24 | 吉林大学 | Personalized customization cervical vertebra zero-notch interbody fusion cage and manufacturing method |
-
2020
- 2020-09-01 CN CN202010906879.1A patent/CN112155805A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113040981A (en) * | 2021-02-08 | 2021-06-29 | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | Polyether-ether-ketone artificial vertebral body |
| CN113040981B (en) * | 2021-02-08 | 2022-07-05 | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | Polyether-ether-ketone artificial vertebral body |
| CN113317860A (en) * | 2021-06-22 | 2021-08-31 | 深圳市艾科赛龙科技股份有限公司 | Prosthesis fixing structure for mandible restoration and three-dimensional model design method |
| CN113317860B (en) * | 2021-06-22 | 2023-03-14 | 深圳市艾科赛龙科技股份有限公司 | Prosthesis fixing structure for mandible restoration and three-dimensional model design method |
| CN116919679A (en) * | 2023-09-18 | 2023-10-24 | 吉林大学 | Personalized customization cervical vertebra zero-notch interbody fusion cage and manufacturing method |
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