CN111265619A - Traditional Chinese medicine composition for preventing or treating sub-health, nano-medicine and preparation method thereof - Google Patents
Traditional Chinese medicine composition for preventing or treating sub-health, nano-medicine and preparation method thereof Download PDFInfo
- Publication number
- CN111265619A CN111265619A CN202010160487.5A CN202010160487A CN111265619A CN 111265619 A CN111265619 A CN 111265619A CN 202010160487 A CN202010160487 A CN 202010160487A CN 111265619 A CN111265619 A CN 111265619A
- Authority
- CN
- China
- Prior art keywords
- parts
- traditional chinese
- chinese medicine
- medicine composition
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 135
- 239000000203 mixture Substances 0.000 title claims abstract description 68
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 36
- 241000190633 Cordyceps Species 0.000 claims abstract description 34
- 240000005373 Panax quinquefolius Species 0.000 claims abstract description 32
- 235000006533 astragalus Nutrition 0.000 claims abstract description 23
- 241001523681 Dendrobium Species 0.000 claims abstract description 20
- 239000000843 powder Substances 0.000 claims description 85
- 239000000463 material Substances 0.000 claims description 35
- 238000002156 mixing Methods 0.000 claims description 30
- 238000001035 drying Methods 0.000 claims description 29
- 241000180649 Panax notoginseng Species 0.000 claims description 27
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 27
- 241000222336 Ganoderma Species 0.000 claims description 22
- 239000011858 nanopowder Substances 0.000 claims description 20
- 239000002245 particle Substances 0.000 claims description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 16
- 239000000706 filtrate Substances 0.000 claims description 16
- 238000001914 filtration Methods 0.000 claims description 16
- 239000002244 precipitate Substances 0.000 claims description 13
- 238000010298 pulverizing process Methods 0.000 claims description 12
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 claims description 11
- 239000007787 solid Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 241000045403 Astragalus propinquus Species 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 235000013305 food Nutrition 0.000 claims description 6
- 240000004638 Dendrobium nobile Species 0.000 claims description 5
- 238000007709 nanocrystallization Methods 0.000 claims description 5
- 230000002265 prevention Effects 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
- 230000001376 precipitating effect Effects 0.000 claims description 3
- 229940079593 drug Drugs 0.000 abstract description 34
- 244000131316 Panax pseudoginseng Species 0.000 abstract description 20
- 240000008397 Ganoderma lucidum Species 0.000 abstract description 19
- 235000001637 Ganoderma lucidum Nutrition 0.000 abstract description 19
- 241001061264 Astragalus Species 0.000 abstract description 15
- 235000003181 Panax pseudoginseng Nutrition 0.000 abstract description 15
- 210000004233 talus Anatomy 0.000 abstract description 15
- 241000721047 Danaus plexippus Species 0.000 abstract description 6
- 230000002195 synergetic effect Effects 0.000 abstract description 6
- 241000411851 herbal medicine Species 0.000 description 48
- 230000000694 effects Effects 0.000 description 36
- 210000004369 blood Anatomy 0.000 description 24
- 239000008280 blood Substances 0.000 description 24
- 201000010099 disease Diseases 0.000 description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 14
- 208000024891 symptom Diseases 0.000 description 14
- 206010016256 fatigue Diseases 0.000 description 13
- 210000002784 stomach Anatomy 0.000 description 13
- 239000002775 capsule Substances 0.000 description 12
- 239000009636 Huang Qi Substances 0.000 description 11
- 238000004140 cleaning Methods 0.000 description 11
- 230000001276 controlling effect Effects 0.000 description 11
- 238000009826 distribution Methods 0.000 description 11
- 241001248610 Ophiocordyceps sinensis Species 0.000 description 10
- 238000012545 processing Methods 0.000 description 10
- 239000000047 product Substances 0.000 description 10
- 239000002552 dosage form Substances 0.000 description 9
- 230000006870 function Effects 0.000 description 9
- 206010012601 diabetes mellitus Diseases 0.000 description 8
- 230000008569 process Effects 0.000 description 8
- 230000001737 promoting effect Effects 0.000 description 7
- 206010020772 Hypertension Diseases 0.000 description 6
- 208000002173 dizziness Diseases 0.000 description 6
- 239000012530 fluid Substances 0.000 description 6
- 239000012535 impurity Substances 0.000 description 6
- 239000011261 inert gas Substances 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- 208000002193 Pain Diseases 0.000 description 5
- 206010033557 Palpitations Diseases 0.000 description 5
- 206010037660 Pyrexia Diseases 0.000 description 5
- 230000036528 appetite Effects 0.000 description 5
- 235000019789 appetite Nutrition 0.000 description 5
- 230000003750 conditioning effect Effects 0.000 description 5
- 230000002354 daily effect Effects 0.000 description 5
- 206010013781 dry mouth Diseases 0.000 description 5
- 210000000936 intestine Anatomy 0.000 description 5
- 239000002086 nanomaterial Substances 0.000 description 5
- 230000036407 pain Effects 0.000 description 5
- 238000012958 reprocessing Methods 0.000 description 5
- 238000005728 strengthening Methods 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 229940126680 traditional chinese medicines Drugs 0.000 description 5
- 206010008479 Chest Pain Diseases 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 4
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 235000009508 confectionery Nutrition 0.000 description 4
- 230000007812 deficiency Effects 0.000 description 4
- 230000002526 effect on cardiovascular system Effects 0.000 description 4
- 210000003414 extremity Anatomy 0.000 description 4
- 235000008434 ginseng Nutrition 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
- 230000000638 stimulation Effects 0.000 description 4
- 235000019640 taste Nutrition 0.000 description 4
- 206010011224 Cough Diseases 0.000 description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 3
- 208000000059 Dyspnea Diseases 0.000 description 3
- 206010013975 Dyspnoeas Diseases 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 206010062717 Increased upper airway secretion Diseases 0.000 description 3
- 206010027566 Micturition urgency Diseases 0.000 description 3
- 208000005392 Spasm Diseases 0.000 description 3
- 230000002159 abnormal effect Effects 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 208000006673 asthma Diseases 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000036760 body temperature Effects 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 230000004069 differentiation Effects 0.000 description 3
- 238000012377 drug delivery Methods 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 230000004438 eyesight Effects 0.000 description 3
- 210000000987 immune system Anatomy 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 208000026435 phlegm Diseases 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 208000013220 shortness of breath Diseases 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- 229940126673 western medicines Drugs 0.000 description 3
- QCBCPALLWXTPLW-SFHVURJKSA-N (2S)-2-(3,4-dihydroxyphenyl)-8,8-dimethyl-2,3,9,10-tetrahydropyrano[2,3-h]chromen-4-one Chemical compound C1([C@@H]2CC(=O)C=3C=CC4=C(C=3O2)CCC(O4)(C)C)=CC=C(O)C(O)=C1 QCBCPALLWXTPLW-SFHVURJKSA-N 0.000 description 2
- 206010002482 Angiosclerosis Diseases 0.000 description 2
- 208000008035 Back Pain Diseases 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 241001289529 Fallopia multiflora Species 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 208000006083 Hypokinesia Diseases 0.000 description 2
- 206010024642 Listless Diseases 0.000 description 2
- 208000019695 Migraine disease Diseases 0.000 description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 2
- 208000032140 Sleepiness Diseases 0.000 description 2
- 206010041349 Somnolence Diseases 0.000 description 2
- 206010047513 Vision blurred Diseases 0.000 description 2
- 208000022531 anorexia Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 230000001914 calming effect Effects 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 206010061428 decreased appetite Diseases 0.000 description 2
- 239000003405 delayed action preparation Substances 0.000 description 2
- 201000006549 dyspepsia Diseases 0.000 description 2
- 210000002683 foot Anatomy 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 210000003128 head Anatomy 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 206010022437 insomnia Diseases 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 230000001788 irregular Effects 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 208000017971 listlessness Diseases 0.000 description 2
- 230000003908 liver function Effects 0.000 description 2
- 235000021266 loss of appetite Nutrition 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 230000003340 mental effect Effects 0.000 description 2
- 230000004089 microcirculation Effects 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 206010027599 migraine Diseases 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 239000002105 nanoparticle Substances 0.000 description 2
- 208000020470 nervous system symptom Diseases 0.000 description 2
- 210000004798 organs belonging to the digestive system Anatomy 0.000 description 2
- -1 pH value Proteins 0.000 description 2
- 230000004793 poor memory Effects 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 230000037321 sleepiness Effects 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- 230000035922 thirst Effects 0.000 description 2
- 230000001256 tonic effect Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- 230000004580 weight loss Effects 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 241000208340 Araliaceae Species 0.000 description 1
- 206010003497 Asphyxia Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 description 1
- 229940123208 Biguanide Drugs 0.000 description 1
- 241000255789 Bombyx mori Species 0.000 description 1
- 206010006100 Bradykinesia Diseases 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 206010006272 Breast mass Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 206010006322 Breath holding Diseases 0.000 description 1
- 206010006326 Breath odour Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 208000002177 Cataract Diseases 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 241001478750 Chlorophytum comosum Species 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 description 1
- 235000007516 Chrysanthemum Nutrition 0.000 description 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 description 1
- 206010010741 Conjunctivitis Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- KQLDDLUWUFBQHP-UHFFFAOYSA-N Cordycepin Natural products C1=NC=2C(N)=NC=NC=2N1C1OCC(CO)C1O KQLDDLUWUFBQHP-UHFFFAOYSA-N 0.000 description 1
- 206010012374 Depressed mood Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010013082 Discomfort Diseases 0.000 description 1
- 206010013789 Dry throat Diseases 0.000 description 1
- 206010015137 Eructation Diseases 0.000 description 1
- 208000004930 Fatty Liver Diseases 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 208000032139 Halitosis Diseases 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 206010019708 Hepatic steatosis Diseases 0.000 description 1
- 241000130660 Hepialidae Species 0.000 description 1
- 208000004898 Herpes Labialis Diseases 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 208000031361 Hiccup Diseases 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 208000019914 Mental Fatigue Diseases 0.000 description 1
- 206010028372 Muscular weakness Diseases 0.000 description 1
- 206010028748 Nasal obstruction Diseases 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 206010067152 Oral herpes Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 235000002791 Panax Nutrition 0.000 description 1
- 241000208343 Panax Species 0.000 description 1
- 235000002789 Panax ginseng Nutrition 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 241000405414 Rehmannia Species 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 206010038776 Retching Diseases 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 206010040007 Sense of oppression Diseases 0.000 description 1
- BHTRKEVKTKCXOH-UHFFFAOYSA-N Taurochenodesoxycholsaeure Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(=O)NCCS(O)(=O)=O)C)C1(C)CC2 BHTRKEVKTKCXOH-UHFFFAOYSA-N 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 208000005946 Xerostomia Diseases 0.000 description 1
- 208000031971 Yin Deficiency Diseases 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 210000001099 axilla Anatomy 0.000 description 1
- 208000019804 backache Diseases 0.000 description 1
- 238000010009 beating Methods 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 230000029145 body fluid secretion Effects 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- OFEZSBMBBKLLBJ-BAJZRUMYSA-N cordycepin Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)C[C@H]1O OFEZSBMBBKLLBJ-BAJZRUMYSA-N 0.000 description 1
- OFEZSBMBBKLLBJ-UHFFFAOYSA-N cordycepine Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(CO)CC1O OFEZSBMBBKLLBJ-UHFFFAOYSA-N 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 208000024829 digestive system symptom Diseases 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000005584 early death Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 208000010706 fatty liver disease Diseases 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 208000001130 gallstones Diseases 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 210000004602 germ cell Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000036449 good health Effects 0.000 description 1
- 210000004209 hair Anatomy 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 239000002122 magnetic nanoparticle Substances 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000008897 memory decline Effects 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 201000003152 motion sickness Diseases 0.000 description 1
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 description 1
- 230000036473 myasthenia Effects 0.000 description 1
- 206010028537 myelofibrosis Diseases 0.000 description 1
- 239000007908 nanoemulsion Substances 0.000 description 1
- 208000010753 nasal discharge Diseases 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 206010034754 petechiae Diseases 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 208000003476 primary myelofibrosis Diseases 0.000 description 1
- 208000017497 prostate disease Diseases 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000014860 sensory perception of taste Effects 0.000 description 1
- 230000036548 skin texture Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000035488 systolic blood pressure Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- BHTRKEVKTKCXOH-LBSADWJPSA-N tauroursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)CC1 BHTRKEVKTKCXOH-LBSADWJPSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
- 230000003867 tiredness Effects 0.000 description 1
- 208000016255 tiredness Diseases 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 239000000439 tumor marker Substances 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 210000004916 vomit Anatomy 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
- 208000016261 weight loss Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/413—Gall bladder; Bile
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Physiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a traditional Chinese medicine composition for preventing or treating sub-health, a nano-medicine and a preparation method thereof, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 170 parts of cordyceps 130-. The Chinese medicinal composition takes the cordyceps, the pseudo-ginseng, the ganoderma lucidum spores and the astragalus as monarch drugs, the American ginseng as minister drugs and the bear gall and the dendrobium as assistant drugs, and can integrally condition and improve the sub-health state of a human body under the mutual synergistic action of the components.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for preventing or treating sub-health, a nano-medicine and a preparation method thereof.
Background
The sub-health is often firstly shown on the body in real life, namely the body is sub-health, the main symptoms comprise fatigue, aching pain, insomnia, haggard, function reduction, dysfunction and the like, people in the sub-health state often feel poor physical strength, fatigue and sleepiness, lack of vitality and facing qi, ① cardiovascular symptoms comprise chest distress, palpitation, shortness of breath, breath holding and the like, ② digestive system symptoms comprise poor appetite, anorexia (the vegetables are seen to have no appetite and sometimes feel hungry but do not want to eat), ③ osteoarticular symptoms comprise waist soreness and backache, joint discomfort or general discomfort, ④ nervous system symptoms comprise frequent head opening, or oppression, fullness, dizziness, poor memory, general weakness, sleepiness, and fatigue, ⑤ sleep symptoms comprise easier waking up in the morning, easier dreaminess, easier urinary dream, less urinary urgency and lower reproductive function, ⑥ urinary urgency and urinary urgency.
The sub-health hazard can cause great influence on daily life all the time, and is mainly characterized in that ① influences work efficiency, life and learning quality, ② influences sleeping quality, aggravates physical and mental fatigue and causes chronic fatigue syndrome, ③ causes vicious circle and causes mental or body diseases, ④ is susceptible to most chronic diseases, such as most malignant tumors, cardiovascular and cerebrovascular diseases and diabetes, specifically comprises hyperlipidemia, fatty liver, hypertension, prostate diseases, abnormal liver functions, gynecological diseases, coronary heart diseases, diabetes, cataract, gallstone and cancer prevention general survey abnormality, ⑤ influences health life, causes premature senility and even causes early death (overwork death) due to sudden emergency.
In view of this, the combination of medicines for conditioning or treatment is required, wherein western medicines are mostly required for symptomatic treatment, the curative effect is single, and the conditioning and treatment effects are limited. Compared with western medicines, the traditional Chinese medicine has more advantages in conditioning and treating sub-health, but the traditional Chinese medicine is poor in relative curative effect and not obvious in effect at present, needs to be taken for a long time, is taken for a long time, increases the burden of a patient, and easily causes adverse symptoms such as diarrhea.
The evaluation of the traditional Chinese medicine on the sub-health is carried out by students of traditional Chinese medicine on the sub-health according to the traditional Chinese medicine theory, and the evaluation method comprises the following 10 standards of ① patients with uneasiness, palpitation and insomnia, ② patients with body fluid secretion caused by sweating and frequent colds, ③ patients with red tongue and tongue fur, bitter taste and dry stool, ④ patients with poor complexion, dark gray and dark surrounding eyes, ⑤ patients with limb expansion, silkworm lying below eyes, ⑥ nail imaging and abnormal change, ⑦ chest swelling before tide, breast nodules, ⑧ vomit adhesive, hiccup fullness, ⑨ abnormal body temperature, lassitude and weakness, ⑩ patients with blurred vision and headache.
Assessment of "sub-health" by modern medicine: modern medicine's assessment of sub-health includes clinical and laboratory examinations; the former includes electrocardiogram, electromyogram, electroencephalogram, ultrasonic examination, X-ray examination, CT examination, nuclear magnetic examination, etc., and the latter includes routine examination (blood, urine, stool, sputum), body fluid examination (gastric juice, cerebrospinal fluid, blood, puncture fluid), bone marrow, liver function, kidney function, blood lipid, blood glucose, tumor marker, etc. The evaluation indexes of sub-health are summarized into 30 items including: mental stress, anxiety and restlessness; autistic, bitter and stuffy; distraction, shallow thinking skin; easy excitement and no trouble; memory decline, the acquaintance forgets the name; the interest becomes light and the desire declines; lazy to contact, low mood; the eyes are easy to feel tired and lack of strength; decreased energy and bradykinesia; dizziness and brain distension, and difficult recovery; dizziness and blurred vision when standing for a long time; the limbs are limp and weak, and the force is not strong; weight loss, weakness; the sleep is not easy to fall, and dreaminess is easy to wake up; morning unwilling and daily dozing; local numbness, easy cooling of hands and feet; sweats in the palms and axilla, dry tongue and dry mouth; spontaneous low fever, night sweat; soreness of the waist and back pain, which causes petechia; the tongue has white fur and the halitosis is self-generated; mouth and tongue ulcers, which occur repeatedly; the sense of taste is not flexible, and the appetite is not good; acid eructation and dyspepsia; defecating and constipation, abdominal distention; susceptible to cold, herpes labialis; nasal obstruction, nasal discharge, sore throat; suffocating and shortness of breath, and urgent respiration; chest pain, chest distress, feeling of pressure in the heart; palpitation, and irregular heart rhythm; tinnitus, ear-back and easy carsickness.
The important idea of preventing and treating diseases in the traditional Chinese medicine is that the traditional Chinese medicine is used for preventing and treating diseases, and the method comprises the following four aspects: the disease is not cured and is kept in good health, and the disease is prevented in the first place; to be rescued, the patient is protected from mild disease; the disease is cured early, and the transmission and the transformation of the disease are prevented; recuperating after illness to prevent recurrence.
The traditional Chinese medicine is a traditional Chinese medicine for tonifying qi and nourishing blood with medicines, and common formulas in daily life are red date, donkey-hide gelatin, astragalus, polygonum multiflorum, American ginseng and the like, but sub-health people are not enough for simply tonifying blood and qi due to the comprehensive imbalance of qi, blood and yin. Taking a formula for tonifying spirit, strengthening qi and essence and blood (trade name: jianyanling capsules) as an example, the formula takes polygonum multiflorum and rhizoma polygonati which are monarch drugs for tonifying liver and kidney and benefiting essence and blood; the prepared rehmannia root, human placenta and other blood nourishing and essence replenishing assistant monarch drugs are used for synergism; the black soya bean is used for promoting blood circulation and diuresis, and the effect of promoting menstruation is matched with monarch and minister tonifying medicines, the seventeen medicines are strictly matched and are complementary to each other, the tonic is supplemented with the product for clearing away the heat in the tonifying process, the tonic is not greasy, and the yin and yang are adjusted, so that the effect that the viscera are strong and the diseases are not disturbed when qi and blood are sufficient in the traditional Chinese medicine is realized, but the effect is still to be improved.
Disclosure of Invention
Based on the above, there is a need for providing a Chinese medicinal composition for preventing or treating sub-health with better curative effect, a nano-medicament and a preparation method thereof.
A traditional Chinese medicine composition comprises the following components in parts by weight: 170 parts of cordyceps 130-.
In one embodiment, in the above traditional Chinese medicine composition, the cordyceps is 150 parts, the panax notoginseng is 120 parts, the panax quinquefolius is 100 parts, the ganoderma robiosa is 150 parts, the bear gall is 40 parts, the dendrobium is 100 parts, and the astragalus membranaceus is 100 parts.
In one embodiment, each component in the traditional Chinese medicine composition is nano powder with the particle size of 1nm-100 nm.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
mixing the components of the traditional Chinese medicine composition to prepare the traditional Chinese medicine composition.
In one embodiment, the step of mixing the components of the traditional Chinese medicine composition comprises the following steps:
crushing the components to obtain crushed materials of the components;
performing nanocrystallization treatment on the crushed materials of the components to prepare nano powder;
mixing the nanometer powders of the above components to obtain the Chinese medicinal composition.
In one embodiment, in the step of crushing the components, the cordyceps sinensis, the panax notoginseng, the American ginseng, the ganoderma robiosa, the bear gall and the dendrobium are respectively crushed by adopting an ultramicro crushing method, and the astragalus membranaceus is crushed by adopting a low-temperature drying and crushing method.
In one embodiment, the step of performing nanocrystallization treatment on the crushed material of each component comprises the following steps:
micronizing the micronized crushed material by a vibration mill;
mixing the micronized powder with water, treating for 3-24h at 90-110 ℃, filtering, collecting filtrate, and concentrating the filtrate to obtain concentrated solution with solid content of 30-50%;
mixing the concentrated solution with ethanol at volume ratio of (0.9-1.2):1, precipitating, filtering, collecting the precipitate, and drying to obtain the nanopowder.
The application of the traditional Chinese medicine composition in preparing medicines or foods for preventing or treating sub-health is provided.
A medicine for preventing or treating sub-health comprises the above Chinese medicinal composition and pharmaceutically acceptable adjuvants.
A method of preparing a medicament for the prevention or treatment of sub-health, comprising the steps of:
providing the traditional Chinese medicine composition and pharmaceutically acceptable auxiliary materials;
mixing the traditional Chinese medicine composition with the pharmaceutically acceptable auxiliary materials to prepare the medicine.
The Chinese medicinal composition takes the cordyceps, the pseudo-ginseng, the ganoderma lucidum spores and the astragalus as monarch drugs, the American ginseng as minister drugs and the bear gall and the dendrobium as assistant drugs, and can integrally condition and improve the sub-health state of a human body under the mutual synergistic action of the components. The traditional Chinese medicine composition carries out the theories of 'holism concept, treatment based on syndrome differentiation', 'tonifying qi and nourishing blood with medicine' and the like, takes people as a whole, focuses on the balance of yin and yang, and focuses on the coordination of five viscera and six entrails, for example: cordyceps has effects in regulating immune system function and relieving fatigue; notoginseng radix has effects of removing blood stasis, stopping bleeding, relieving swelling and relieving pain; the ganoderma lucidum spores have various effects of improving microcirculation, reducing cholesterol, avoiding angiosclerosis, strengthening functions of liver, spleen and stomach, strengthening digestive organs and the like; the American ginseng has the effects of tonifying qi and yin, clearing heat and promoting fluid production, and is used for treating deficiency of qi and yin, internal heat, cough, asthma, phlegm and blood, asthenic fever, vexation and fatigue, diabetes, dry mouth and throat and the like; bear gall has the effects of clearing heat, calming liver and improving eyesight; the dendrobium nobile lindl has the efficacies of benefiting stomach and promoting fluid production, nourishing yin and clearing heat, and utilizes the difference of the onset time and the difference of the efficacy degree of different medicines and the mutual synergistic effect, so that the traditional Chinese medicine composition has better comprehensive curative effect.
Detailed Description
In order that the invention may be more fully understood, a more particular description of the invention will now be rendered by reference to specific embodiments thereof that are illustrated in the appended drawings. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
The invention provides a traditional Chinese medicine composition which comprises the following active components: 170 parts of cordyceps 130-.
The Chinese medicinal composition takes the cordyceps, the pseudo-ginseng, the ganoderma lucidum spores and the astragalus as monarch drugs, the American ginseng as minister drugs and the bear gall and the dendrobium as assistant drugs, and can integrally condition and improve the sub-health state of a human body under the mutual synergistic action of the components. The traditional Chinese medicine composition carries out the theories of ' holism concept, treatment based on syndrome differentiation ' and treatment based on syndrome differentiation such as nourishing qi and blood with medicines ' and the like, takes people as a whole, focuses on the balance of yin and yang, and focuses on the coordination of five zang-organs and six fu-organs, for example: cordyceps has effects in regulating immune system function and relieving fatigue; notoginseng radix has effects of removing blood stasis, stopping bleeding, relieving swelling and relieving pain; the ganoderma lucidum spores have various effects of improving microcirculation, reducing cholesterol, avoiding angiosclerosis, strengthening functions of liver, spleen and stomach, strengthening digestive organs and the like; the American ginseng has the effects of tonifying qi and yin, clearing heat and promoting fluid production, and is used for treating deficiency of qi and yin, internal heat, cough, asthma, phlegm and blood, asthenic fever, vexation and fatigue, diabetes, dry mouth and throat and the like; bear gall has the effects of clearing heat, calming liver and improving eyesight; the dendrobium nobile lindl has the efficacies of benefiting stomach and promoting fluid production, nourishing yin and clearing heat, and utilizes the difference of the onset time and the difference of the efficacy degree of different medicines and the mutual synergistic effect, so that the traditional Chinese medicine composition has better comprehensive curative effect.
Further, the traditional Chinese medicine composition comprises the following active components in parts by weight: 160 parts of 140-140 parts of cordyceps sinensis, 150 parts of 110-150 parts of pseudo-ginseng, 90-110 parts of American ginseng, 160 parts of 140-110 parts of ganoderma robusta, 40-50 parts of bear gall, 90-110 parts of dendrobium and 90-110 parts of astragalus membranaceus.
Furthermore, in the traditional Chinese medicine composition, the cordyceps sinensis is 150 parts, the panax notoginseng is 120 parts, the American ginseng is 100 parts, the ganoderma robe is 150 parts, the bear gall is 40 parts, the dendrobe is 100 parts, and the astragalus membranaceus is 100 parts, so that the components have the optimal synergistic effect.
Furthermore, each component in the Chinese medicinal composition is nano powder with the particle size of 1nm-100 nm. Furthermore, each component in the Chinese medicinal composition is nano powder with the particle size of 50nm-80 nm.
It is understood that the components of the traditional Chinese medicine composition can be prepared into nano powder and then mixed, or the components can be prepared into nano powder after being mixed, and the components are understood to be in the protection scope of the invention.
The nanometer powder prepared from the traditional Chinese medicine composition can improve bioavailability, increase targeting property, reduce toxic and side effects, show new drug effect, broaden the indications of the original drug, enrich the dosage form selection of the traditional Chinese medicine, reduce the dosage and save the traditional Chinese medicine resources. More specifically, the following advantages are provided:
(1) improve or increase the solubility and bioavailability of Chinese medicinal materials. Traditional Chinese medicines are usually decoction, but some components in the traditional Chinese medicines are low in solubility in water (or other solvents), so that the traditional Chinese medicines are not suitable for being prepared into various dosage forms for clinical use. The prepared nano powder can well solve the problem of solubility of the components, is convenient for preparation and improves the effectiveness of the medicament.
(2) Is convenient for preparing sustained release preparation or controlled release preparation. The half-life period of part of the traditional Chinese medicine components is short, the slow release or controlled release purpose cannot be achieved, the traditional Chinese medicine composition is similar to western medicines with short half-life period, the effective blood concentration in vivo can be maintained only by frequent administration, and the problem can be solved by adopting the nanometer traditional Chinese medicine composition.
(3) Targeted drug delivery. The prepared nano traditional Chinese medicine composition can adopt different high molecular materials or carry out surface modification according to the difference of physiological enzyme and bacteria distribution, cell distribution, reticular structure, lymph distribution and the like of different parts in vivo, so as to prepare the required traditional Chinese medicine nano particles which are conveyed to a specified target area; the magnetic nano-particles can also be prepared by adopting a method of combining in vivo and in vitro to achieve the aim of targeted drug delivery.
(4) Smart drug delivery systems (feedback regulated release of drug). The nanometer Chinese medicine composition may be prepared into nanometer particle, liposome, etc. and through proper surface modification or grafting with polymer material sensitive to some enzyme, pH value, protein and other change in physiological environment, the medicine release of the Chinese medicine preparation may be controlled based on some change information.
(5) Reduce the stimulation of some traditional Chinese medicines to the stomach and intestine. The stimulation of the oral traditional Chinese medicine to the stomach and intestine is related to the granularity and the release speed of the medicine, the medicine with the stimulation to the stomach and intestine is prepared into nano particles, nano emulsion and the like, and then the proper administration form is adopted to reduce the local 'accumulation' release of the medicine in the stomach and avoid or reduce the stimulation of the medicine to the stomach and intestine.
In one embodiment, the cordyceps is cordyceps powder, the panax notoginseng is panax notoginseng powder, the American ginseng is American ginseng powder, the ganoderma robiosa is ganoderma robiosa powder, the bear gall is bear gall powder, the dendrobium is dendrobium powder, and the astragalus is astragalus powder.
Cordyceps sinensis powder: is powder prepared by pulverizing Cordyceps, wherein the Cordyceps is complex of stroma and larva body of Cordyceps parasitized on larva of insect of Hepialidae, and has effects of regulating immune system function, relieving fatigue, etc. as main active ingredients, such as cordycepin, cordycepic acid (i.e. D-mannitol), and Cordyceps polysaccharide, which are beneficial for human body absorption.
Pseudo-ginseng powder: also named as pseudo-ginseng powder, the pseudo-ginseng powder is a root and stem product of the plant pseudo-ginseng (the scientific name: Panax pseudo-ginseng), which is powder made by beating the main root of pseudo-ginseng. The name is Tianqi powder, which is not changed. It is warm in nature, sweet and slightly bitter in taste, and enters liver, stomach and large intestine meridians. Also called as northern ginseng and southern pseudo-ginseng. Ginseng, radix Ginseng, tonifies qi the first, and radix Notoginseng, tonifies blood the first.
Ganoderma lucidum spore powder: ganoderma spore is the seeds of Ganoderma lucidum which is the tiny egg-shaped germ cells ejected from Ganoderma lucidum fold during the growth and maturation period. Each ganoderma spore is only 4-6 microns, is a living organism, has a double-wall structure, is surrounded by hard chitin cellulose, and is difficult to be fully absorbed by a human body. After the wall is broken, the medicine is more suitable for direct absorption of intestines and stomach of human body. It is the essence of Ganoderma, and has all the genetic materials and health promotion effects of Ganoderma.
American ginseng powder: american ginseng (scientific name: Panax quinquefolius) is a perennial herb plant of Panax of Araliaceae, namely American ginseng, American ginseng and American ginseng, the main root is round or spindle-shaped, the surface is light yellow or yellowish white, the color is glossy, the skin texture is fine, the texture is full and durable, the cut-off section is clean, the cut-off section presents clear chrysanthemum texture, the ginseng slice is sweet and bitter, has strong taste, is through the throat and has no hairs on the whole. The root pulp is spindle-shaped and sometimes divergent. The rhizome is short. The stems are cylindrical, about 25cm in length, with longitudinal striations, or slight edges. It has the functions of invigorating vital energy, nourishing Yin, clearing away heat and promoting the secretion of saliva. Can be used for treating deficiency of qi and yin, internal heat, cough, asthma, phlegm, asthenia, fever, vexation, fatigue, diabetes, xerostomia, and dry throat. The radix Panacis Quinquefolii powder is prepared by pulverizing dried root and rhizome of radix Panacis Quinquefolii into powder.
Bear gall powder: bear gall powder, which is powder, irregular fragments or particles, brown yellow, green yellow or dark brown, semitransparent and has glass-like luster. Has crisp texture, easy moisture absorption, faint scent and slight fishy smell, extremely bitter and slightly sweet taste and cool feeling. The main effective component of the bear gall powder, namely tauroursodeoxycholic acid, is not less than 23 percent according to the standard issued by the ministry of China. Cold in nature, non-toxic, bitter and sweet in taste, fragrant and slightly fishy. Bear gall powder has strong pain relieving and spasm relieving effects, and has strong inhibition effect on gram-positive bacteria. Is suitable for treating various pains caused by traumatic injury, stagnated fire and excessive heat, and can be used for treating infantile diseases; cool wind, conjunctivitis, furuncle, hemorrhoid and malignant boil, etc. It also can promote synthesis of hepatic carbohydrate source from sugar and lactic acid, and enhance insulin action and secretion, thereby reducing blood sugar and urine sugar.
Dendrobe powder: dendrobe (school name: Dendrobium nobile Lindl), also named as herba Dendrobii charm, herba Nerviliae Fordii, herba Hylotelephii Erythrosticti, Zine immortal plant, Chlorophytum comosum, Linlan, Busheng, herba Dendrobii, etc. The stem is upright, the meat is fleshy and thick, the stem is slightly flat and cylindrical, the length of the stem is 10-60 cm, and the thickness of the stem reaches 1.3 cm. The medicinal plants, sweet, light and slightly salty in nature and taste, are cold and enter stomach, kidney and lung meridians. To nourish stomach, promote the production of body fluid, nourish yin and clear heat. Can be used for treating yin deficiency and fluid deficiency, dry mouth, polydipsia, anorexia, retching, asthenic fever after disease, and dim and unclear vision. The herba Dendrobii powder is prepared by pulverizing herba Dendrobii into powder.
The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps:
mixing the components of the Chinese medicinal composition to obtain the Chinese medicinal composition.
Further, the step of mixing the components of the Chinese medicinal composition may comprise the steps of:
s101: pulverizing the above materials to obtain pulverized product.
It is understood that step S101 may further include a step of cleaning and drying the components, for example, a high-speed centrifuge is used to clean and separate the Chinese herbal medicines, such as cordyceps sinensis, panax notoginseng, panax quinquefolius, astragalus membranaceus, ganoderma lucidum spores, bear gall and dendrobium nobile, so as to remove silt and various impurities of the Chinese herbal medicines. The Chinese herbal medicines can be fresh medicinal materials or medicinal materials after treatment (such as sun drying and the like), and are not particularly limited.
In step S101, the related components may be pulverized by using an existing pulverization method, or related pulverized materials may be directly purchased, and the selection of the pulverization method may be selected according to the properties of the medicinal materials.
Preferably, the cordyceps, the panax notoginseng, the American ginseng, the ganoderma robe, the bear gall and the dendrobium are respectively crushed by adopting an ultramicro crushing method; drying and pulverizing radix astragali at low temperature. Wherein, the superfine grinding method has the grinding principle that: the material gets into crushing room by the loading hopper, smashes through the blade of high-speed rotation, adjusts the distance that grading wheel and classifying disc reach required material fineness, and the material that reaches the requirement is introduced into the collection box sack from crushing room to the high-speed rotatory fan blade, and the material that does not reach the requirement continues to smash in crushing room, and the dust that collection box sack produced is collected by the suction box and is smashed to required particle size distribution. In one embodiment, the particle size distribution after pulverization is 5 μm to 10 μm. In one embodiment, the minimum temperature used in the low-temperature drying and pulverizing method is-50 ℃ to-20 ℃.
And S102, performing nanocrystallization treatment on the crushed materials of the components to prepare nano powder.
Further, step S102 includes the steps of:
s1021: carrying out micronization treatment on the crushed materials of the components by adopting a ball mill;
in one embodiment, the micronization process is carried out by a high-energy horizontal ball mill, the ball powder ratio of the high-energy horizontal ball mill is kept in a certain proportion by high temperature and high pressure, vacuum or inert gas atmosphere is kept in a tank, the rotating speed and time of the high-energy ball mill are controlled, and the micronization process of the traditional Chinese medicine can be completed by controlling the temperature (the control range is 50-100 ℃). In one embodiment, the particle size of the pulverized material of each component is less than 10 microns after micronization.
After micronization, a vibration mill (preferably an eccentric vibration mill) can be used for breaking the wall to ensure that the particle size of the powder is less than 10 microns, which is beneficial to the subsequent steps.
S1022: the pulverized material subjected to the micronization treatment was sequentially extracted.
Further, step S1022 includes the steps of:
(a) mixing the micronized powder with water, treating for 3-24h at 90-110 deg.C (preferably 100 deg.C), filtering, collecting filtrate, and concentrating the filtrate to obtain concentrated solution with solid content of 30% -50% (preferably 40%);
(b) mixing the concentrated solution with ethanol at volume ratio of (0.9-1.2):1, precipitating, filtering, collecting precipitate, and drying to obtain nanopowder.
By adopting the method to prepare the nano powder, the uniformity of the particle size of the nano powder can be effectively improved.
S103: mixing the nanometer powders of the above materials, and making into Chinese medicinal composition.
In step S103, mixing may be carried out by using a mixer, and preferably, mixing may be carried out by using a twin-screw high-speed mixer.
Compared with the method that the raw materials are directly mixed and then subjected to nano treatment, the method has the advantages that appropriate parameters can be conveniently selected according to the properties of the medicinal materials of all the components, so that the uniformity of the particle size of all the components in a final product is ensured, and the preparation is convenient.
The invention also provides application of the traditional Chinese medicine composition in preparing medicines or foods for preventing or treating sub-health.
The traditional Chinese medicine composition can well regulate and improve the sub-health state of a human body, dredge blood circulation, relieve dyspepsia, improve sleep, regulate hormone secretion and the like, has better comprehensive curative effect, and is particularly suitable for preparing medicines or food for preventing or treating sub-health.
It can be understood that the above-mentioned traditional Chinese medicine composition can be mixed with corresponding pharmaceutically acceptable auxiliary materials, and can be made into the medicine with required dosage form alone, also can be combined with other medicines, and is not limited herein. The food includes beverage, solid or semi-solid food, and is understood to be within the scope of the present invention.
The invention also provides a medicament for preventing or treating sub-health, which comprises the traditional Chinese medicine composition and pharmaceutically acceptable auxiliary materials.
It is understood that the dosage form of the above-mentioned drugs is not particularly limited, and may be capsules, granules, powders, tablets, pills, etc., and the dosage form is not particularly limited, and the corresponding excipients may be selected to prepare the desired dosage form. The Chinese medicinal composition is as described above, and is not described herein again.
The medicine is especially suitable for conditioning and improving the sub-health state of middle-aged and elderly people, improving immunity, improving cardiovascular and cerebrovascular circulation state, and clearing away heat and toxic materials; is suitable for diabetic patients, and has strong auxiliary effect on reducing blood sugar and urine sugar of diabetic patients; is suitable for patients with hypertension.
The invention also provides a preparation method of the medicine for preventing or treating sub-health, which comprises the following steps:
s201, providing the traditional Chinese medicine composition and pharmaceutically acceptable auxiliary materials.
The traditional Chinese medicine composition and the preparation method thereof are as described above, and are not described herein again. The auxiliary materials may be those conventionally used in the art, and are not particularly limited.
S202, mixing the traditional Chinese medicine composition with the pharmaceutically acceptable auxiliary materials to prepare the medicine.
In step S202, suitable excipients may be selected according to the dosage form of the drug, the preparation method is not particularly limited, and the existing preparation process may be adopted, which is not particularly limited herein.
In one embodiment, the dosage form of the medicament is a capsule; furthermore, the medicine is a capsule, and the specification is 0.4 g multiplied by 60 grains.
The present invention will be described below with reference to specific examples.
Example 1
The dosage form of the medicament of the embodiment is capsules
The traditional Chinese medicine composition in the medicine comprises the following components in parts by weight (g): 150 parts of cordyceps powder, 150 parts of pseudo-ginseng powder, 100 parts of American ginseng powder, 150 parts of ganoderma lucidum spore powder, 40 parts of bear gall powder, 100 parts of dendrobium powder and 100 parts of astragalus membranaceus.
The preparation method comprises the following steps:
(1) cleaning and separating the Chinese herbal medicines such as Cordyceps, Notoginseng radix, radix Panacis Quinquefolii, radix astragali, Ganoderma spore, fel Ursi, and herba Dendrobii with high speed centrifuge, respectively, to remove silt and various impurities of the Chinese herbal medicines.
(2) Drying Chinese herbal medicines such as Cordyceps, Notoginseng radix, radix Panacis Quinquefolii, radix astragali, Ganoderma spore, fel Ursi, and herba Dendrobii with constant temperature dryer respectively.
(3) Thoroughly cleaning and drying Chinese herbal medicines such as cordyceps sinensis, panax notoginseng, American ginseng, ganoderma lucidum spores, bear gall and dendrobium, crushing by using a Chinese herbal medicine ultrafine crusher, reprocessing the astragalus Chinese herbal medicines, drying and crushing at low temperature to obtain crushed substances of the components, wherein the particle size distribution is 5-10 microns.
(4) Processing the crushed components by a high-energy horizontal ball mill, keeping an inert gas atmosphere in a tank, controlling the rotating speed of the high-energy ball mill to be 1000-1500 rpm, controlling the temperature to be within the range of 50-100 ℃ to complete the micronization process, then mixing the powder with water, processing for 6 hours at 100 ℃, filtering, collecting filtrate, and concentrating the filtrate to obtain a concentrated solution with the solid content of 40%; mixing the concentrated solution with ethanol at a volume ratio of 1:1, separating out precipitate, filtering, collecting the precipitate, and drying to obtain 50-80 nm Chinese herbal medicine powder.
(5) The 7 Chinese herbal medicine nano-powder is strictly arranged and proportioned and is fully and uniformly mixed by a nano-material double-helix high-speed mixer.
(6) The mixed nano Chinese herbal medicine powder is prepared into capsules by adopting a modern preparation process and a full-automatic capsule filling production line, and the specification is 0.4 g multiplied by 60 granules.
Example 2
The traditional Chinese medicine composition in the medicine comprises the following components in parts by weight (g): 170 parts of cordyceps powder, 170 parts of pseudo-ginseng powder, 120 parts of American ginseng powder, 160 parts of ganoderma lucidum spore powder, 60 parts of bear gall powder, 120 parts of dendrobium powder and 120 parts of astragalus powder.
(1) Cleaning and separating the Chinese herbal medicines such as Cordyceps, Notoginseng radix, radix Panacis Quinquefolii, radix astragali, Ganoderma spore, fel Ursi, and herba Dendrobii with high speed centrifuge, respectively, to remove silt and various impurities of the Chinese herbal medicines.
(2) Drying Chinese herbal medicines such as Cordyceps, Notoginseng radix, radix Panacis Quinquefolii, radix astragali, Ganoderma spore, fel Ursi, and herba Dendrobii with constant temperature dryer respectively.
(3) Thoroughly cleaning and drying Chinese herbal medicines such as cordyceps sinensis, panax notoginseng, American ginseng, ganoderma lucidum spores, bear gall and dendrobium, crushing by using a Chinese herbal medicine ultrafine crusher, reprocessing the astragalus Chinese herbal medicines, drying and crushing at low temperature to obtain crushed substances of the components, wherein the particle size distribution is 5-10 microns.
(4) Processing the crushed components by a high-energy horizontal ball mill, keeping an inert gas atmosphere in a tank, controlling the rotating speed of the high-energy ball mill to be 1000-1500 rpm, controlling the temperature to be within the range of 50-100 ℃ to complete the micronization process, then mixing the powder with water, processing for 6 hours at 100 ℃, filtering, collecting filtrate, and concentrating the filtrate to obtain a concentrated solution with the solid content of 40%; mixing the concentrated solution with ethanol at a volume ratio of 1:1, separating out precipitate, filtering, collecting the precipitate, and drying to obtain 50-80 nm Chinese herbal medicine powder.
(5) The 7 Chinese herbal medicine nano-powder is strictly arranged and proportioned and is fully and uniformly mixed by a nano-material double-helix high-speed mixer.
(6) And subpackaging the mixed nano Chinese herbal medicine powder to obtain the product.
Example 3
The traditional Chinese medicine composition in the medicine comprises the following components in parts by weight (g): 160 parts of cordyceps powder, 160 parts of pseudo-ginseng powder, 120 parts of American ginseng powder, 160 parts of ganoderma lucidum spore powder, 50 parts of bear gall powder, 110 parts of dendrobium powder and 110 parts of astragalus powder.
The preparation method comprises the following steps:
(1) cleaning and separating the Chinese herbal medicines such as Cordyceps, Notoginseng radix, radix Panacis Quinquefolii, radix astragali, Ganoderma spore, fel Ursi, and herba Dendrobii with high speed centrifuge, respectively, to remove silt and various impurities of the Chinese herbal medicines.
(2) Drying Chinese herbal medicines such as Cordyceps, Notoginseng radix, radix Panacis Quinquefolii, radix astragali, Ganoderma spore, fel Ursi, and herba Dendrobii with constant temperature dryer respectively.
(3) Thoroughly cleaning and drying Chinese herbal medicines such as cordyceps sinensis, panax notoginseng, American ginseng, ganoderma lucidum spores, bear gall and dendrobium, crushing by using a Chinese herbal medicine ultrafine crusher, reprocessing the astragalus Chinese herbal medicines, drying and crushing at low temperature to obtain crushed substances of the components, wherein the particle size distribution is 5-10 microns.
(4) Processing the crushed components by a high-energy horizontal ball mill, keeping an inert gas atmosphere in a tank, controlling the rotating speed of the high-energy ball mill to be 1000-1500 rpm, controlling the temperature to be within the range of 50-100 ℃ to complete the micronization process, then mixing the powder with water, processing for 6 hours at 100 ℃, filtering, collecting filtrate, and concentrating the filtrate to obtain a concentrated solution with the solid content of 40%; mixing the concentrated solution with ethanol at a volume ratio of 1:1, separating out precipitate, filtering, collecting the precipitate, and drying to obtain 50-80 nm Chinese herbal medicine powder.
(5) The 7 Chinese herbal medicine nano-powder is strictly arranged and proportioned and is fully and uniformly mixed by a nano-material double-helix high-speed mixer.
(6) And subpackaging the mixed nano Chinese herbal medicine powder to obtain the product.
Example 4
The traditional Chinese medicine composition in the medicine comprises the following components in parts by weight (g): 150 parts of cordyceps powder, 150 parts of pseudo-ginseng powder, 100 parts of American ginseng powder, 150 parts of ganoderma lucidum spore powder, 40 parts of bear gall powder, 100 parts of dendrobium powder and 100 parts of astragalus powder.
(1) Cleaning and separating the Chinese herbal medicines such as Cordyceps, Notoginseng radix, radix Panacis Quinquefolii, radix astragali, Ganoderma spore, fel Ursi, and herba Dendrobii with high speed centrifuge, respectively, to remove silt and various impurities of the Chinese herbal medicines.
(2) Drying Chinese herbal medicines such as Cordyceps, Notoginseng radix, radix Panacis Quinquefolii, radix astragali, Ganoderma spore, fel Ursi, and herba Dendrobii with constant temperature dryer respectively.
(3) Thoroughly cleaning and drying Chinese herbal medicines such as cordyceps sinensis, panax notoginseng, American ginseng, ganoderma lucidum spores, bear gall and dendrobium, crushing by using a Chinese herbal medicine ultrafine crusher, reprocessing the astragalus Chinese herbal medicines, drying and crushing at low temperature to obtain crushed substances of the components, wherein the particle size distribution is 5-10 microns.
(4) Processing the crushed components by a high-energy horizontal ball mill, keeping an inert gas atmosphere in a tank, controlling the rotating speed of the high-energy ball mill to be 1000-1500 rpm, controlling the temperature to be within the range of 50-100 ℃ to complete the micronization process, then mixing the powder with water, processing for 6 hours at 100 ℃, filtering, collecting filtrate, and concentrating the filtrate to obtain a concentrated solution with the solid content of 40%; mixing the concentrated solution with ethanol at a volume ratio of 1:1, separating out precipitate, filtering, collecting the precipitate, and drying to obtain 50-80 nm Chinese herbal medicine powder.
(5) The 7 Chinese herbal medicine nano-powder is strictly arranged and proportioned and is fully and uniformly mixed by a nano-material double-helix high-speed mixer.
(6) And subpackaging the mixed nano Chinese herbal medicine powder to obtain the product.
Example 5
The traditional Chinese medicine composition in the medicine comprises the following components in parts by weight (g): 160 parts of cordyceps powder, 160 parts of pseudo-ginseng powder, 110 parts of American ginseng powder, 150 parts of ganoderma lucidum spore powder, 60 parts of bear gall powder, 110 parts of dendrobium powder and 110 parts of astragalus powder.
(1) Cleaning and separating the Chinese herbal medicines such as Cordyceps, Notoginseng radix, radix Panacis Quinquefolii, radix astragali, Ganoderma spore, fel Ursi, and herba Dendrobii with high speed centrifuge, respectively, to remove silt and various impurities of the Chinese herbal medicines.
(2) Drying Chinese herbal medicines such as Cordyceps, Notoginseng radix, radix Panacis Quinquefolii, radix astragali, Ganoderma spore, fel Ursi, and herba Dendrobii with constant temperature dryer respectively.
(3) Thoroughly cleaning and drying Chinese herbal medicines such as cordyceps sinensis, panax notoginseng, American ginseng, ganoderma lucidum spores, bear gall and dendrobium, crushing by using a Chinese herbal medicine ultrafine crusher, reprocessing the astragalus Chinese herbal medicines, drying and crushing at low temperature to obtain crushed substances of the components, wherein the particle size distribution is 5-10 microns.
(4) Processing the crushed components by a high-energy horizontal ball mill, keeping an inert gas atmosphere in a tank, controlling the rotating speed of the high-energy ball mill to be 1000-1500 rpm, controlling the temperature to be within the range of 50-100 ℃ to complete the micronization process, then mixing the powder with water, processing for 6 hours at 100 ℃, filtering, collecting filtrate, and concentrating the filtrate to obtain a concentrated solution with the solid content of 40%; mixing the concentrated solution with ethanol at a volume ratio of 1:1, separating out precipitate, filtering, collecting the precipitate, and drying to obtain 50-80 nm Chinese herbal medicine powder.
(5) The 7 Chinese herbal medicine nano-powder is strictly arranged and proportioned and is fully and uniformly mixed by a nano-material double-helix high-speed mixer.
(6) And subpackaging the mixed nano Chinese herbal medicine powder to obtain the product.
Effect testing experiment
The product of the invention is safe, the capsule in the embodiment 1 is adopted to determine that the capsule with normal dosage has obvious conditioning and improving function effects, 200 (with the age distribution of 40-65 years) male and female patients (120 male and 80 female) of middle-aged and elderly people are treated, the average treatment course is 90 days, the symptom change and adverse reaction before and after treatment are observed, the observation time is from before the administration starts to the symptom disappearance or 30 days, and the specific curative effect is shown in the table 1
Candidate enrollment requirements: (1) patients with cardiovascular symptoms (including hypertension) often feel chest distress, palpitation, short breath, suffocation and the like; (2) patients with nervous system symptoms often suffer from headache, or have stuffiness, fullness, dizziness, poor memory, general weakness, and fatigue, and are particularly easy to fatigue; (3) patients with sleep symptoms are difficult to fall asleep, are easy to wake up early in the morning and often dreams at night;
the medication method comprises the following steps: the capsule (4 capsules 1.6g containing 16.5g crude drug) in example 1 is administered 2 times a day, one capsule each time, and 90 days is a course of treatment. The preparation is administered for one treatment course, and is administered for 1 treatment course and 3 treatment courses each year.
The judgment standard of the sub-health curative effect is as follows: sub-health symptom self-rating scale (SC-SHS-Q) is used clinically.
And (3) curing: the body temperature is normal, and various symptoms disappear;
improvement: the body temperature is normal, and various symptoms are relieved;
the disease is not cured: none.
TABLE 1
| Scoring | Number of people |
| Cure of disease | 145 |
| Improvement of life | 32 |
| Not cured | 23 |
| Cure rate | 88.5％ |
The cure rate is (cure + improvement)/the total number of people
As can be seen from Table 1, the product of example 1 has a better therapeutic effect and the physical condition of the selected patients is obviously improved.
Several typical cases are listed below:
case 1: mr. Li, age 44, enterprise researchers, little sports, long-term work on desk, high working pressure, frequent tiredness of the body, listlessness and frequent migraine after age 40, and after 2 courses of continuous medication, the vigor is very vigorous and the migraine symptoms disappear.
Case 2: the female suffering from hypertension is 55 years old, and patients suffering from hypertension have high blood pressure, dizziness and myasthenia of limbs, the systolic pressure before taking the medicine is 150mmHg and 93mmHg, and after continuously taking other related blood pressure lowering medicines for 2 treatment courses, the blood pressure is reduced to be close to a standard range, the head is not dizzy, and the limbs are powerful.
Case 3: mr. Yang, 71 years old with a history of lung cancer, 67 years old with tumor surgery, listlessness, after continuous medication for 3 treatment courses a year, the effect is very obvious, the tumor is reduced, nearly three years no enlargement, and the spirit looks bright.
Case 4: the muscle and tendon spasm can be caused by birth of Mr. Wang, the age is 60 years old, the muscle and tendon spasm can be caused by one night, after 1 treatment course of continuous medication, the effect is very obvious, the hands and the feet are alive at night, and the qi and the blood are smooth.
Case 5: mr. Sun, age 62, diabetic, weight obesity, general fatigue, weakness, thirst, frequent micturition, low salt and fat in diet, no drinking, walking 30 minutes after meals every day, and taking biguanide hypoglycemic drugs for a long time, but the blood sugar is unstable. Before and after the product is used, the life and the rest are basically consistent, after 2 treatment courses of continuous medication, the effect is very obvious, three months of continuous tracking are carried out, the blood sugar index is normal and basically stabilized at 10.5mmol/L after meal. The symptoms of hypodynamia, thirst and frequent micturition are basically relieved and are not taken again in the tracking period.
Case 6: old women, 88 years old, patients with breast cancer, 81 years old have had mastectomy, the appetite is always poor, after continuous medication for 3 treatment courses for one year, the effect is obvious, the cancer does not relapse or transfer, and the appetite is increased.
Case 7: mr. Zhang, 60 years old, Mild bone marrow fibrosis (PMF), anemia, loss of appetite, weight loss, shortness of breath, palpitations. After continuous administration for 1 year and 3 treatment courses, the effect is obvious, hemoglobin is increased, appetite is recovered to be normal, weight is increased, daily life and daily life are regular.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
1. The traditional Chinese medicine composition is characterized by comprising the following components in parts by weight: 170 parts of cordyceps 130-.
2. The traditional Chinese medicine composition of claim 1, wherein the cordyceps is 150 parts, the panax notoginseng is 120 parts, the panax quinquefolius is 100 parts, the ganoderma robiosa is 150 parts, the bear gall is 40 parts, the dendrobium is 100 parts, and the astragalus membranaceus is 100 parts.
3. The traditional Chinese medicine composition according to claim 1 or 2, wherein each component in the traditional Chinese medicine composition is a nano powder with a particle size of 1nm-100 nm.
4. A method for preparing the Chinese medicinal composition of any one of claims 1 to 3, which comprises the following steps:
mixing the components of the traditional Chinese medicine composition to prepare the traditional Chinese medicine composition.
5. The method for preparing the Chinese medicinal composition according to claim 4, wherein the step of mixing the components of the Chinese medicinal composition comprises the following steps:
crushing the components to obtain crushed materials of the components;
performing nanocrystallization treatment on the crushed materials of the components to prepare nano powder;
mixing the nanometer powders of the above components to obtain the Chinese medicinal composition.
6. The preparation method of claim 5, wherein in the step of pulverizing the components, the Cordyceps, the Panax notoginseng, the Panax quinquefolium, the Ganodorma robusta, the fel Ursi and the Dendrobium nobile are pulverized respectively by adopting an ultramicro pulverization method, and the Astragalus membranaceus is pulverized by adopting a low-temperature drying pulverization method.
7. The method according to claim 5, wherein the step of subjecting the pulverized material of each component to nanocrystallization comprises the steps of:
micronizing the micronized crushed material by a vibration mill;
mixing the micronized powder with water, treating for 3-24h at 90-110 ℃, filtering, collecting filtrate, and concentrating the filtrate to obtain concentrated solution with solid content of 30-50%;
mixing the concentrated solution with ethanol at volume ratio of (0.9-1.2):1, precipitating, filtering, collecting the precipitate, and drying to obtain the nanopowder.
8. Use of a Chinese medicinal composition according to any one of claims 1 to 3 in the manufacture of a medicament or food product for the prevention or treatment of sub-health.
9. A medicament for the prevention or treatment of sub-health, comprising the Chinese medicinal composition of any one of claims 1 to 3 and a pharmaceutically acceptable excipient.
10. A method for preparing a medicament for preventing or treating sub-health, comprising the steps of:
providing the traditional Chinese medicine composition of any one of claims 1-3 and pharmaceutically acceptable auxiliary materials;
mixing the traditional Chinese medicine composition with the pharmaceutically acceptable auxiliary materials.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010160487.5A CN111265619A (en) | 2020-03-10 | 2020-03-10 | Traditional Chinese medicine composition for preventing or treating sub-health, nano-medicine and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010160487.5A CN111265619A (en) | 2020-03-10 | 2020-03-10 | Traditional Chinese medicine composition for preventing or treating sub-health, nano-medicine and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111265619A true CN111265619A (en) | 2020-06-12 |
Family
ID=70991395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010160487.5A Pending CN111265619A (en) | 2020-03-10 | 2020-03-10 | Traditional Chinese medicine composition for preventing or treating sub-health, nano-medicine and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111265619A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670991A (en) * | 2012-05-14 | 2012-09-19 | 贵州省赤水市金钗石斛产业开发有限公司 | Preparation method for dendrobium nobile extractum |
-
2020
- 2020-03-10 CN CN202010160487.5A patent/CN111265619A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670991A (en) * | 2012-05-14 | 2012-09-19 | 贵州省赤水市金钗石斛产业开发有限公司 | Preparation method for dendrobium nobile extractum |
Non-Patent Citations (1)
| Title |
|---|
| 金道山等: "保元丹对小鼠免疫功能的实验研究", 《免疫学杂志》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100353983C (en) | Chinese medicine preparation for reducing sugar | |
| CN102342992B (en) | Chinese medicinal composition for treating insomnia and preparation method of preparation thereof | |
| CN101947284B (en) | Traditional Chinese medicinal composition for treating diabetes and preparation method thereof | |
| WO2023125797A1 (en) | Traditional chinese medicine composition and preparation method and application thereof | |
| CN101810787A (en) | Chinese medicinal composition for treating dysphoria and preparation method thereof | |
| CN106490558A (en) | A kind of health-care honey and preparation method thereof | |
| CN105943953A (en) | Health product for treating diabetes and preparation method thereof | |
| CN1142785C (en) | Antifatigue capsule | |
| CN104800553B (en) | A kind of Chinese medicine composition for treating climacteric insomnia disease and preparation method thereof | |
| CN111265619A (en) | Traditional Chinese medicine composition for preventing or treating sub-health, nano-medicine and preparation method thereof | |
| CN106074765A (en) | A kind of Chinese medicine composition of sleep of calming the nerves, help | |
| CN101406625B (en) | Chinese medicinal composition for treating cancer as well as preparation method and use thereof | |
| CN104324134A (en) | Traditional Chinese medicine composition for improving microcirculation and preparation method of traditional Chinese medicine composition | |
| CN108853340A (en) | A kind of Chinese medicine of nourishing the liver and kidney and preparation method thereof | |
| CN104688855B (en) | A kind of Chinese goldthread colla corii asini composition for treating chronic fatigue syndrome and its application | |
| CN102626471A (en) | Traditional Chinese medicine composition with effects of anti-anaphylaxis, desensitization, repair and regeneration | |
| CN106334145A (en) | Cough-relieving and intestine-lubricating honey and preparation method thereof | |
| CN106692821A (en) | Traditional Chinese medicine preparation for treating neurosurgical postoperative headache | |
| CN105343508A (en) | Method for preparing traditional Chinese medicine composition for treating climacteric syndrome | |
| CN105012732A (en) | Traditional Chinese medicine pill for treating sleep disorder syndrome and preparation method thereof | |
| CN1166383C (en) | Medicine for treating tumor in digestive tract and its prepn | |
| CN116672374A (en) | Qi-tonifying, yang-tonifying and anti-fatigue traditional Chinese medicine composition as well as preparation method and application thereof | |
| CN104815179A (en) | Traditional Chinese medicine composition for treating neurasthenia type sleep disorder and preparation method of traditional Chinese medicine composition | |
| CN104013850A (en) | Pharmaceutical composition for relieving malaise after chemoradiotherapy and preparation method thereof | |
| CN102631493B (en) | Health care composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200612 |