CN111250020A - Reaction unit is used in biological medicine preparation - Google Patents

Reaction unit is used in biological medicine preparation Download PDF

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Publication number
CN111250020A
CN111250020A CN201811463566.2A CN201811463566A CN111250020A CN 111250020 A CN111250020 A CN 111250020A CN 201811463566 A CN201811463566 A CN 201811463566A CN 111250020 A CN111250020 A CN 111250020A
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CN
China
Prior art keywords
kettle body
back flow
kettle
reaction
wall
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201811463566.2A
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Chinese (zh)
Inventor
刘凯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pizhou High Tech Zone Biomedical Research Institute Co ltd
Original Assignee
Pizhou High Tech Zone Biomedical Research Institute Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pizhou High Tech Zone Biomedical Research Institute Co ltd filed Critical Pizhou High Tech Zone Biomedical Research Institute Co ltd
Priority to CN201811463566.2A priority Critical patent/CN111250020A/en
Publication of CN111250020A publication Critical patent/CN111250020A/en
Pending legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/18—Stationary reactors having moving elements inside
    • B01J19/1868—Stationary reactors having moving elements inside resulting in a loop-type movement
    • B01J19/1881—Stationary reactors having moving elements inside resulting in a loop-type movement externally, i.e. the mixture leaving the vessel and subsequently re-entering it
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/82—Combinations of dissimilar mixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71805—Feed mechanisms characterised by the means for feeding the components to the mixer using valves, gates, orifices or openings
    • B01F35/718051—Feed mechanisms characterised by the means for feeding the components to the mixer using valves, gates, orifices or openings being adjustable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/80—Forming a predetermined ratio of the substances to be mixed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/90—Heating or cooling systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0006—Controlling or regulating processes
    • B01J19/0013—Controlling the temperature of the process
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/02—Apparatus characterised by being constructed of material selected for its chemically-resistant properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/90—Heating or cooling systems
    • B01F2035/98—Cooling
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/90—Heating or cooling systems
    • B01F2035/99—Heating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00132—Controlling the temperature using electric heating or cooling elements
    • B01J2219/00135—Electric resistance heaters

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Accessories For Mixers (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)

Abstract

The invention discloses a reaction device for preparing biological medicine, which comprises a kettle body, wherein a polyurethane layer covers the outer wall of the kettle body, a first feed inlet is arranged at the left end of the upper side of the kettle body, a second feed inlet is arranged at the right end of the upper side of the kettle body, a first electromagnetic valve is arranged on the first feed inlet and a second feed inlet, a control device for adjusting the opening degree of the first electromagnetic valve is arranged on the reaction kettle, and a stirring rotating shaft is vertically arranged in the kettle body. Keep the temperature invariable relatively, remove convenient and fast in addition, the noise at work is low.

Description

Reaction unit is used in biological medicine preparation
Technical Field
The invention relates to a biological medicine production device, in particular to a reaction device for biological medicine preparation.
Background
In the production process of biological medicines, a reaction kettle is often needed, the reaction kettle is used for mixing different materials to enable the materials to react, the reaction kettle carries out structural design and parameter configuration on a container according to different process condition requirements, and the design conditions, the process, the inspection, the manufacturing and the acceptance are required to be according to related technical standards so as to realize the heating, the evaporation, the cooling and the low-speed and high-speed mixing reaction functions of the process requirements. Present reation kettle needs artifical reinforced, unable accurate reinforced, the production efficiency of biological medicine has been influenced, when carrying out some reaction, need carry out constantly with reaction steam cooling backward flow, present reation kettle does not all have such function, present agitating unit is when the stirring, because the horizontal position relatively fixed of stirring rake, the stirring is mixed and is gone on a horizontal plane often, be unfavorable for the mixing of stirring rake upper and lower position material, whether the material can be abundant react and depend on agitating unit can the agitator or not the stirring.
Disclosure of Invention
The present invention is directed to a reaction apparatus for preparing a biomedical drug, which solves the above problems of the prior art.
In order to achieve the purpose, the invention provides the following technical scheme:
a reaction device for preparing biological medicines comprises a kettle body, wherein a polyurethane layer covers the outer wall of the kettle body, a first feed inlet is arranged at the left end of the upper side of the kettle body, a second feed inlet is arranged at the right end of the upper side of the kettle body, first electromagnetic valves are arranged on the first feed inlet and the second feed inlet, a control device for adjusting the opening degree of the first electromagnetic valve is arranged on the reaction kettle, a stirring rotating shaft is vertically arranged in the kettle body, a stirring paddle is arranged on the outer wall of the stirring rotating shaft, the top end of the stirring rotating shaft penetrates through the outer side of the kettle body and is connected with a driving motor, a silencing cover is arranged on the outer side of the driving motor, a steam outlet is arranged at the top end of the left side wall of the kettle body, a sealing cover is arranged on the periphery of the steam outlet, a condenser is connected onto the steam outlet through a pipeline, a return pipe is also connected, bat air pump and condenser are connected and all are equipped with the second control valve on the pipeline of three-way pipe, still be equipped with compounding heating device on the cauldron body, compounding heating device includes the back flow, oil cistern and circulating pump, the back flow setting leans on last position on cauldron body right side, the circulating pump is established ties and is set up on the back flow that is close to cabinet body right side intermediate position, the upper end level of back flow extends to the inside of the cauldron body, a toroidal tube of back flow terminal UNICOM, evenly distributed has the hole for water spraying on the downside outer wall of toroidal tube, the toroidal tube sets up the top at the internal stirring rake of cauldron, one section that the back flow links to each other with cauldron body right side middle section lateral wall is the coil pipe form, and sets up in the oil cistern, one section pipeline outside that the back flow is close to cauldron body upside right side wall is equipped with electric heating wire, be.
As a further scheme of the invention: the thickness of the polyurethane layer is 8-15 mm.
As a further scheme of the invention: four groups of stirring paddles are arranged up and down.
As a still further scheme of the invention: the silencing cover is made of a sound insulation damping felt.
Compared with the prior art, the invention has the beneficial effects that: the polyurethane layer has the advantages of good tensile strength, tear strength, impact resistance, wear resistance, weather resistance, hydrolysis resistance, sealing sound insulation, oil resistance and the like, the wear resistance, impact resistance, cracking resistance and heat insulation performance of the kettle body can be improved, the control device can automatically adjust the opening and closing degree of the first electromagnetic valve according to actual needs to complete automatic accurate feeding, the automation degree is high, the noise reduction cover can effectively reduce the noise of the driving motor during working, and the working environment of operators is improved; a steam outlet of the kettle body is connected to a condenser, steam is introduced to the condenser to be cooled into water for backflow, and meanwhile, the pressure reduction of the kettle body is controlled by an exhaust pump, so that the operation is convenient, and the practicability is high; the material that compounding heating device passes through the back flow and carries out the circulation with cauldron body lower extreme and upper end and carry out the circulation transport and flow, fully guarantee material misce bene, the electric heating wire that the one end that is close to cauldron body upper end lateral wall on the back flow set up is unanimous with the cauldron is internal in order to maintain the temperature of reaction material in the back flow, overcome the influence to constancy of temperature because of reaction material's extrinsic cycle, keep the temperature relatively invariable, the effectual reaction efficiency that has improved, guarantee the reactant quality, the setting up of gyro wheel makes reation kettle remove convenient and fast, and the convenience is high.
Drawings
FIG. 1 is a schematic structural diagram of a high-efficiency reaction kettle for biological medicine preparation.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1, in an embodiment of the present invention, a reaction apparatus for preparing a biological medicine includes a kettle 1, a polyurethane layer 2 covers an outer wall of the kettle 1, a thickness of the polyurethane layer 2 is 8-15mm, a first feed port 3 is disposed at a left end of an upper side of the kettle 1, a second feed port 4 is disposed at a right end of the upper side of the kettle 1, a first electromagnetic valve 5 is disposed on each of the first feed port 3 and the second feed port 4, a control device for adjusting an opening degree of the first electromagnetic valve 5 is disposed on the reaction kettle, a stirring rotating shaft 6 is vertically disposed inside the kettle 1, stirring paddles 7 are disposed on an outer wall of the stirring rotating shaft 6, four groups of the stirring paddles 7 are disposed at upper and lower sides, a top end of the stirring rotating shaft 7 penetrates through an outer side of the kettle 1 and is connected to a driving motor 8, a noise reduction cover 9 is disposed at an outer side of the driving motor 8, the noise reduction cover 9 is, The kettle has the advantages of tear strength, impact resistance, wear resistance, weather resistance, hydrolysis resistance, sealing sound insulation, oil resistance and the like, the wear resistance, impact resistance, cracking resistance and heat insulation performance of the kettle body 1 can be improved, the control device can automatically adjust the opening and closing degree of the first electromagnetic valve 5 according to actual needs to finish automatic accurate feeding, the automation degree is high, the noise reduction cover 9 can effectively reduce the noise of the driving motor 8 during working, and the working environment of operators is improved; the top end of the left side wall of the kettle body 1 is provided with a steam outlet 10, a sealing cover is arranged on the periphery of the steam outlet 10, the steam outlet 10 is connected with a condenser 11 through a pipeline, the upper end of the left side of the kettle body 1 is also connected with a return pipe 12, the outlet end of the left end of the return pipe 12 is connected with a three-way pipe, the other two ends of the three-way pipe are respectively connected with an air flap pump 13 and the condenser 11, the air flap pump 13 and the condenser 11 are both connected with a second control valve 14 on the pipeline of the three-way pipe, the steam outlet 10 of the kettle body 1 is connected to the condenser 11, steam is introduced onto the condenser 11 to be cooled into water to be refluxed, and meanwhile the pressure; the kettle body 1 is also provided with a mixing heating device, the mixing heating device comprises a return pipe 18, an oil liquid groove 20 and a circulating pump 21, the return pipe 18 is arranged at the upper position of the right side of the kettle body 1, the circulating pump 21 is serially connected with the return pipe 18 close to the middle position of the right side of the cabinet body 1, the upper end of the return pipe 18 horizontally extends to the inside of the kettle body 1, the tail end of the return pipe 18 is communicated with a ring pipe 15, the outer wall of the lower side of the ring pipe 15 is uniformly distributed with water spray holes, the ring pipe 15 is arranged above a stirring paddle 7 in the kettle body 1, one section of the return pipe 18 connected with the side wall of the middle section of the right side of the kettle body 1 is in a coil shape and is arranged in the oil liquid groove 20, the outer side of one section of a pipeline 16 of the return pipe 18 close to the side wall of the right side of, the material mixing and heating device circularly conveys and flows the materials at the lower end and the upper end of the kettle body through the return pipe 18, so that the materials are fully and uniformly mixed, the electric heating wire 17 arranged at one end of the return pipe 18 close to the side wall at the upper end of the kettle body is used for maintaining the temperature of the reaction materials in the return pipe 18 consistent with that in the kettle body, the influence of the external circulation of the reaction materials on the constant temperature is overcome, the temperature is kept relatively constant, the reaction efficiency is effectively improved, the quality of the reaction materials is ensured, and the reaction kettle is convenient and fast to move and high in convenience due to the arrangement of the; the efficient reaction kettle for preparing the biological medicine can automatically and accurately feed materials according to actual needs, also improves the wear resistance, impact resistance, cracking resistance and heat preservation performance of the reaction kettle, introduces steam onto a condenser to be cooled into water for backflow, controls pressure reduction in the reaction kettle body through an exhaust pump, is convenient to operate, can fully and uniformly mix materials, completely reacts, overcomes the influence of external circulation of the reaction materials on constant temperature, keeps the temperature relatively constant, is convenient and quick to move, and has low working noise.
The working principle of the invention is as follows: the polyurethane layer has the advantages of good tensile strength, tear strength, impact resistance, wear resistance, weather resistance, hydrolysis resistance, sealing sound insulation, oil resistance and the like, the wear resistance, impact resistance, cracking resistance and heat insulation performance of the kettle body 1 can be improved, the control device can automatically adjust the opening and closing degree of the first electromagnetic valve 5 according to actual needs to complete automatic accurate feeding, the automation degree is high, the noise reduction cover 9 can effectively reduce the noise of the driving motor 8 during working, and the working environment of operators is improved; a steam outlet 10 of the kettle body 1 is connected to a condenser 11, steam is introduced to the condenser 11 to be cooled into water for backflow, and meanwhile, the pressure reduction of the kettle body 1 is controlled by an exhaust pump 13, so that the operation is convenient, and the practicability is high; the material that compounding heating device passes through back flow 18 and carries out the circulation with cauldron body lower extreme and upper end and carry out the circulation transport and flow, fully guarantee the material misce bene, the electric heating wire 17 that the one end that is close to cauldron body upper end lateral wall set up on the back flow 18 is unanimous with the cauldron is internal in order to maintain the temperature of reaction material in back flow 18, overcome the influence to the constancy of temperature because of reaction material's extrinsic cycle, keep the temperature invariable relatively, the effectual reaction efficiency that has improved, guarantee the reactant quality, setting up of gyro wheel 23 makes reation kettle remove convenient and fast, and the convenience is high.

Claims (4)

1. A reaction device for preparing biological medicines comprises a kettle body and is characterized in that a polyurethane layer covers the outer wall of the kettle body, a first feed port is arranged at the left end of the upper side of the kettle body, a second feed port is arranged at the right end of the upper side of the kettle body, first electromagnetic valves are arranged on the first feed port and the second feed port, a control device for adjusting the opening degree of the first electromagnetic valves is arranged on the reaction kettle, a stirring rotating shaft is vertically arranged in the kettle body, a stirring paddle is arranged on the outer wall of the stirring rotating shaft, the top end of the stirring rotating shaft penetrates through the outer side of the kettle body and is connected with a driving motor, a silencing cover is arranged on the outer side of the driving motor, a steam outlet is arranged at the top end of the left side wall of the kettle body, a sealing cover is arranged on the periphery of the steam outlet, the steam outlet is connected with a condenser through a pipeline, a return pipe is also connected at, bat air pump and condenser are connected and all are equipped with the second control valve on the pipeline of three-way pipe, still be equipped with compounding heating device on the cauldron body, compounding heating device includes the back flow, oil cistern and circulating pump, the back flow setting leans on last position on cauldron body right side, the circulating pump is established ties and is set up on the back flow that is close to cabinet body right side intermediate position, the upper end level of back flow extends to the inside of the cauldron body, a toroidal tube of back flow terminal UNICOM, evenly distributed has the hole for water spraying on the downside outer wall of toroidal tube, the toroidal tube sets up the top at the internal stirring rake of cauldron, one section that the back flow links to each other with cauldron body right side middle section lateral wall is the coil pipe form, and sets up in the oil cistern, one section pipeline outside that the back flow is close to cauldron body upside right side wall is equipped with electric heating wire, be.
2. The reaction device for biomedical preparation according to claim 1, wherein the thickness of the polyurethane layer is 8-15 mm.
3. The reaction device for biomedical preparation according to claim 1, wherein the stirring paddles are provided in four sets up and down.
4. The reaction device for biomedical preparation according to claim 1, wherein the noise reduction cover is made of sound insulation damping felt.
CN201811463566.2A 2018-11-30 2018-11-30 Reaction unit is used in biological medicine preparation Pending CN111250020A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811463566.2A CN111250020A (en) 2018-11-30 2018-11-30 Reaction unit is used in biological medicine preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201811463566.2A CN111250020A (en) 2018-11-30 2018-11-30 Reaction unit is used in biological medicine preparation

Publications (1)

Publication Number Publication Date
CN111250020A true CN111250020A (en) 2020-06-09

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ID=70943721

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201811463566.2A Pending CN111250020A (en) 2018-11-30 2018-11-30 Reaction unit is used in biological medicine preparation

Country Status (1)

Country Link
CN (1) CN111250020A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115041121A (en) * 2022-07-01 2022-09-13 孔冬秀 Intelligent temperature control chemical production reaction kettle

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115041121A (en) * 2022-07-01 2022-09-13 孔冬秀 Intelligent temperature control chemical production reaction kettle

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Application publication date: 20200609