CN111249335A - Preparation method of radix angelicae and radix salviae miltiorrhizae wall-broken decoction pieces - Google Patents

Preparation method of radix angelicae and radix salviae miltiorrhizae wall-broken decoction pieces Download PDF

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CN111249335A
CN111249335A CN201911287219.3A CN201911287219A CN111249335A CN 111249335 A CN111249335 A CN 111249335A CN 201911287219 A CN201911287219 A CN 201911287219A CN 111249335 A CN111249335 A CN 111249335A
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angelica dahurica
slices
wall
radix angelicae
salvia miltiorrhiza
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马峰
石学敏
马绍桓
梁秀红
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Tianma Anhui Traditional Chinese Medicine Technology Co ltd
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Tianma Anhui Traditional Chinese Medicine Technology Co ltd
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    • A61K36/18Magnoliophyta (angiosperms)
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Abstract

The invention discloses a preparation method of radix angelicae and radix salviae miltiorrhizae wall-broken decoction pieces, which comprises the following steps: weighing quantitatively, cleaning the main material, slicing, frying, cooking, drying, crushing, granulating, sterilizing, packaging and storing; the invention also discloses radix angelicae and salvia miltiorrhiza wall-broken decoction pieces, and the formula of the radix angelicae and salvia miltiorrhiza wall-broken decoction pieces comprises the following components: 20-25% of radix angelicae, 10-14% of salvia miltiorrhiza, 5-9% of copper, 1-4% of notopterygium root, 3-6% of cocklebur fruit, 2-5% of magnolia flower, 3-7% of mint, 8-12% of soaking agent, 9-13% of impregnating compound and the balance of deionized water; the beneficial effects are that: the formula adopted by the invention is the raw materials specified by the national standard, the wall-broken radix angelicae and radix salviae miltiorrhizae decoction pieces prepared by the invention are greatly improved, and the blood-activating and pain-relieving performance of the decoction pieces is improved by adding the radix salviae miltiorrhizae, so that the decoction pieces are more practical and can be eaten by women in menstrual period; the addition of the cocklebur fruit, the magnolia flower, the mint, the bronze and the notopterygium root improves the headache treatment performance of the decoction pieces.

Description

Preparation method of radix angelicae and radix salviae miltiorrhizae wall-broken decoction pieces
Technical Field
The invention relates to the technical field of preparation of radix angelicae decoction pieces, and particularly relates to a preparation method of radix angelicae and radix salviae miltiorrhizae wall-broken decoction pieces.
Background
Radix angelicae, the name of traditional Chinese medicine, is a perennial big herb with a height of 1-2.5 meters, a cylindrical root with a diameter of 2-5 cm at the base of the stem, a basal leaf with a pinnate division, a multiple umbrella-shaped inflorescence with a terminal growth or lateral growth, and a long-round fruit with an oval shape. The main varieties include radix Angelicae Dahuricae, radix Angelicae Dahuricae (original variety), and radix Angelicae Pubescentis; the root is used as a medicine, and has the functions of dispelling diseases, removing dampness, expelling pus, promoting granulation, promoting blood circulation, relieving pain and the like; can be used for treating wind-cold type common cold, headache, rhinitis, and toothache. Can also be used as perfume for treating leucorrhea with red and white discharge, pain, furuncle, and toxic swelling; some northern provinces are cultivated, so that the production is self-selling, and the adjustment is omitted for a small number of provinces; generally under the forest, at the forest edge, beside the stream, in the shrubs and on the mountain and valley grasslands;
in the prior art, with the popularization of a medicine wall breaking technology, radix angelicae wall breaking decoction pieces are used for treating symptoms of activating blood and relieving pain in the market, but for menstrual women, the traditional radix angelicae wall breaking piece is poor in blood activating performance, so that the articles produced by the radix angelicae wall breaking decoction pieces cannot adapt to various crowds.
Disclosure of Invention
The invention aims to provide a preparation method of radix angelicae and radix salviae miltiorrhizae wall-broken decoction pieces, which aims to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme: a preparation method of radix angelicae and radix salviae miltiorrhizae wall-broken decoction pieces comprises the following steps:
s1: quantitative weighing, namely weighing all the raw materials according to the components;
s2: cleaning the main materials, namely soaking the angelica dahurica and the salvia miltiorrhiza in clear water for 20-40 min, then soaking in 0.5% acetic acid solution for 1-2 h, taking out, and naturally drying;
s3: slicing and frying, namely slicing the angelica dahurica and the salvia miltiorrhiza which are dried in the step two, controlling the thickness of the slices to be 0.2cm, frying by adopting slow fire for 6-10 min until the surfaces of the slices after frying are not obviously changed in color and texture, and paying attention to that the angelica dahurica and the salvia miltiorrhiza are respectively and independently fried;
s4: steaming and drying, namely putting the fried angelica dahurica slices into a soaking agent while the fried angelica dahurica slices are hot, adding deionized water until the mixed liquid just submerges the angelica dahurica slices, steaming and boiling the angelica dahurica slices for 2 to 4 hours under pressure, taking out the angelica dahurica slices after the juice is completely absorbed, taking out the angelica dahurica slices, airing the angelica dahurica slices until the angelica dahurica slices are dried from four to six times, putting the angelica dahurica slices into a high-voltage electric field dryer again, treating the angelica dahurica slices for 2 hours at 55 ℃ with the electric field strength of 360kV/m, taking out the angelica dahurica slices, spraying a wetting agent on the surfaces of the angelica dahurica slices to keep the surfaces of the angelica;
s5: pulverizing radix Angelicae Dahuricae, Saviae Miltiorrhizae radix, herba cistanches, Notopterygii rhizoma, fructus Xanthii, flos Magnoliae and herba Menthae, sequentially adding into a wall breaking machine, breaking wall, pulverizing, sieving, and coarse powder of 105 mesh; then placing the prepared coarse powder into an ultrafine grinder, grinding for 20-35 min at 15 ℃, and grinding to 400 meshes to obtain ultrafine powder;
s6: granulating and sterilizing, namely preparing the ultrafine powder obtained in the step five into a soft material by using deionized water, putting the prepared soft material into a rotary granulator to obtain mixture granules, and putting the mixture granules into an ultraviolet sterilizer for sterilization and drying;
and S7, packaging and storing, subpackaging the mixture granules obtained in the step six under the aseptic condition to obtain the finished product, and storing in a ventilated and dry place.
The formula of the radix angelicae and salvia miltiorrhiza wall-broken decoction pieces comprises the following components: 20-25% of angelica dahurica, 10-14% of salvia miltiorrhiza, 5-9% of copper, 1-4% of notopterygium root, 3-6% of cocklebur fruit, 2-5% of magnolia flower, 3-7% of mint, 8-12% of soaking agent, 9-13% of impregnating compound and the balance of deionized water.
Preferably, the traditional Chinese medicine composition comprises 20% of angelica dahurica, 14% of salvia miltiorrhiza, 5% of copper, 4% of notopterygium root, 3% of cocklebur fruit, 5% of magnolia flower, 3% of mint, 8% of soaking agent, 9% of impregnating compound and the balance of deionized water.
Preferably, the traditional Chinese medicine composition comprises 25% of angelica dahurica, 10% of salvia miltiorrhiza, 9% of copper kidney, 1% of notopterygium root, 6% of cocklebur fruit, 2% of magnolia flower, 7% of mint, 12% of soaking agent, 13% of impregnating compound and the balance of deionized water.
Preferably, the traditional Chinese medicine composition comprises 22% of angelica dahurica, 12% of salvia miltiorrhiza, 7% of copper kidney, 2% of notopterygium root, 4% of cocklebur fruit, 3% of magnolia flower, 4% of mint, 9% of soaking agent, 10% of impregnating compound and the balance of deionized water.
Preferably, the traditional Chinese medicine composition comprises 23% of angelica dahurica, 13% of salvia miltiorrhiza, 8% of copper kidney, 3% of notopterygium root, 5% of cocklebur fruit, 4% of magnolia flower, 5% of mint, 11% of soaking agent, 11% of impregnating compound and the balance of deionized water.
Preferably, the soaking agent is ginger juice, and the soaking agent is yellow wine or dark plum extract or a mixture of the yellow wine and the dark plum extract.
Compared with the prior art, the invention has the beneficial effects that: the formula adopted by the invention is the raw materials specified by the national standard, the wall-broken radix angelicae and radix salviae miltiorrhizae decoction pieces prepared by the invention are greatly improved, and the blood-activating and pain-relieving performance of the decoction pieces is improved by adding the radix salviae miltiorrhizae, so that the decoction pieces are more practical and can be eaten by women in menstrual period; the addition of the cocklebur fruit, the magnolia flower, the mint, the bronze and the notopterygium root improves the headache treatment performance of the decoction pieces.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example one
The invention provides a technical scheme that: a preparation method of radix angelicae and radix salviae miltiorrhizae wall-broken decoction pieces comprises the following steps:
s1: quantitative weighing, namely weighing all the raw materials according to the components;
s2: cleaning the main materials, soaking radix Angelicae Dahuricae and Saviae Miltiorrhizae radix in clear water for 20min, soaking in 0.5% acetic acid solution for 1 hr, taking out, and naturally air drying;
s3: slicing and frying, namely slicing the angelica dahurica and the salvia miltiorrhiza which are dried in the step two, controlling the thickness of the slices to be 0.2cm, frying by adopting slow fire for 6min until no obvious color and texture change exists on the surfaces of the slices after frying, and paying attention to that the angelica dahurica and the salvia miltiorrhiza are respectively and independently fried;
s4: steaming and drying, namely putting the fried angelica dahurica slices into a soaking agent while the fried angelica dahurica slices are hot, adding deionized water until the mixed liquid just submerges the angelica dahurica slices, steaming and boiling for 2h under pressure, taking out after the juice is absorbed completely, taking out, airing to be dried from four to six times, putting into a high-voltage electric field dryer again, treating for 2h at 55 ℃, taking out, spraying a wetting agent on the surface of the angelica dahurica slices to keep the surface of the angelica dahurica slices in a wet state, standing for 15min, putting into the high-voltage electric field dryer, and treating for 2h at 65 ℃;
s5: pulverizing radix Angelicae Dahuricae, Saviae Miltiorrhizae radix, herba cistanches, Notopterygii rhizoma, fructus Xanthii, flos Magnoliae and herba Menthae, sequentially adding into a wall breaking machine, breaking wall, pulverizing, sieving, and coarse powder of 105 mesh; then placing the obtained coarse powder into an ultrafine pulverizer, pulverizing for 20min at 15 ℃, and pulverizing to 400 meshes to obtain ultrafine powder;
s6: granulating and sterilizing, namely preparing the ultrafine powder obtained in the step five into a soft material by using deionized water, putting the prepared soft material into a rotary granulator to obtain mixture granules, and putting the mixture granules into an ultraviolet sterilizer for sterilization and drying;
and S7, packaging and storing, subpackaging the mixture granules obtained in the step six under the aseptic condition to obtain the finished product, and storing in a ventilated and dry place.
The formula of the radix angelicae and salvia miltiorrhiza wall-broken decoction pieces comprises the following components: 20% of angelica dahurica, 14% of salvia miltiorrhiza, 5% of copper, 4% of notopterygium root, 3% of cocklebur fruit, 5% of biond magnolia flower, 3% of mint, 8% of soaking agent, 9% of impregnating compound and the balance of deionized water.
Wherein the soaking agent is ginger juice, and the soaking agent is yellow wine.
Example two
The invention provides a technical scheme that: a preparation method of radix angelicae and radix salviae miltiorrhizae wall-broken decoction pieces comprises the following steps:
s1: quantitative weighing, namely weighing all the raw materials according to the components;
s2: cleaning the main materials, soaking radix Angelicae Dahuricae and Saviae Miltiorrhizae radix in clear water for 25min, soaking in 0.5% acetic acid solution for 1.2 hr, taking out, and naturally air drying;
s3: slicing and frying, namely slicing the angelica dahurica and the salvia miltiorrhiza which are dried in the step two, controlling the thickness of the slices to be 0.2cm, frying by adopting slow fire for 7min until no obvious color and texture change exists on the surfaces of the slices after frying, and paying attention to that the angelica dahurica and the salvia miltiorrhiza are respectively and independently fried;
s4: steaming and drying, namely putting the fried angelica dahurica slices into a soaking agent while the fried angelica dahurica slices are hot, adding deionized water until the mixed liquid just submerges the angelica dahurica slices, steaming and boiling the angelica dahurica slices for 2.4 hours under pressure, taking out the angelica dahurica slices after the juice is completely absorbed, taking out the angelica dahurica slices, airing the angelica dahurica slices until the angelica dahurica slices are dried from four to six times, putting the angelica dahurica slices into a high-voltage electric field dryer again, treating the angelica dahurica slices for 2 hours at 55 ℃ with the electric field strength of 360kV/m, taking out the angelica dahurica slices, spraying a wetting agent on the surfaces of the angelica dahurica slices to keep the surfaces of the angelica;
s5: pulverizing radix Angelicae Dahuricae, Saviae Miltiorrhizae radix, herba cistanches, Notopterygii rhizoma, fructus Xanthii, flos Magnoliae and herba Menthae, sequentially adding into a wall breaking machine, breaking wall, pulverizing, sieving, and coarse powder of 105 mesh; then placing the obtained coarse powder in an ultrafine pulverizer, pulverizing for 25min at 15 deg.C, and pulverizing to 400 mesh to obtain ultrafine powder;
s6: granulating and sterilizing, namely preparing the ultrafine powder obtained in the step five into a soft material by using deionized water, putting the prepared soft material into a rotary granulator to obtain mixture granules, and putting the mixture granules into an ultraviolet sterilizer for sterilization and drying;
and S7, packaging and storing, subpackaging the mixture granules obtained in the step six under the aseptic condition to obtain the finished product, and storing in a ventilated and dry place.
The formula of the radix angelicae and salvia miltiorrhiza wall-broken decoction pieces comprises the following components: 25% of angelica dahurica, 10% of salvia miltiorrhiza, 9% of copper, 1% of notopterygium root, 6% of cocklebur fruit, 2% of biond magnolia flower, 7% of mint, 12% of soaking agent, 13% of impregnating compound and the balance of deionized water.
Wherein the soaking agent is ginger juice, and the soaking agent is dark plum extract.
EXAMPLE III
The invention provides a technical scheme that: a preparation method of radix angelicae and radix salviae miltiorrhizae wall-broken decoction pieces comprises the following steps:
s1: quantitative weighing, namely weighing all the raw materials according to the components;
s2: cleaning the main materials, soaking radix Angelicae Dahuricae and Saviae Miltiorrhizae radix in clear water for 30min, soaking in 0.5% acetic acid solution for 1.5 hr, taking out, and naturally air drying;
s3: slicing and frying, namely slicing the angelica dahurica and the salvia miltiorrhiza which are dried in the step two, controlling the thickness of the slices to be 0.2cm, frying by adopting slow fire for 8min until no obvious color and texture change exists on the surfaces of the slices after frying, and paying attention to that the angelica dahurica and the salvia miltiorrhiza are respectively and independently fried;
s4: steaming and drying, namely putting the fried angelica dahurica slices into a soaking agent while the fried angelica dahurica slices are hot, adding deionized water until the mixed liquid just submerges the angelica dahurica slices, steaming and boiling the angelica dahurica slices for 3.4 hours under pressure, taking out the angelica dahurica slices after the juice is completely absorbed, taking out the angelica dahurica slices, airing the angelica dahurica slices until the angelica dahurica slices are dried from four to six times, putting the angelica dahurica slices into a high-voltage electric field dryer again, treating the angelica dahurica slices for 2 hours at 55 ℃ with the electric field strength of 360kV/m, taking out the angelica dahurica slices, spraying a wetting agent on the surfaces of the angelica dahurica slices to keep the surfaces in a wet;
s5: pulverizing radix Angelicae Dahuricae, Saviae Miltiorrhizae radix, herba cistanches, Notopterygii rhizoma, fructus Xanthii, flos Magnoliae and herba Menthae, sequentially adding into a wall breaking machine, breaking wall, pulverizing, sieving, and coarse powder of 105 mesh; then placing the obtained coarse powder into an ultrafine pulverizer, pulverizing for 29min at 15 ℃, and pulverizing to 400 meshes to obtain ultrafine powder;
s6: granulating and sterilizing, namely preparing the ultrafine powder obtained in the step five into a soft material by using deionized water, putting the prepared soft material into a rotary granulator to obtain mixture granules, and putting the mixture granules into an ultraviolet sterilizer for sterilization and drying;
and S7, packaging and storing, subpackaging the mixture granules obtained in the step six under the aseptic condition to obtain the finished product, and storing in a ventilated and dry place.
The formula of the radix angelicae and salvia miltiorrhiza wall-broken decoction pieces comprises the following components: 22% of angelica dahurica, 12% of salvia miltiorrhiza, 7% of copper, 2% of notopterygium root, 4% of cocklebur fruit, 3% of biond magnolia flower, 4% of mint, 9% of soaking agent, 10% of impregnating compound and the balance of deionized water.
Wherein the soaking agent is ginger juice, and the soaking agent is a mixture of yellow wine and dark plum extract.
Example four
The invention provides a technical scheme that: a preparation method of radix angelicae and radix salviae miltiorrhizae wall-broken decoction pieces comprises the following steps:
s1: quantitative weighing, namely weighing all the raw materials according to the components;
s2: cleaning the main materials, soaking radix Angelicae Dahuricae and Saviae Miltiorrhizae radix in clear water for 40min, soaking in 0.5% acetic acid solution for 2 hr, taking out, and naturally air drying;
s3: slicing and frying, namely slicing the angelica dahurica and the salvia miltiorrhiza which are dried in the step two, controlling the thickness of the slices to be 0.2cm, frying by adopting slow fire for 10min until no obvious color and texture change exists on the surfaces of the slices after frying, and paying attention to that the angelica dahurica and the salvia miltiorrhiza are respectively and independently fried;
s4: steaming and drying, namely putting the fried angelica dahurica slices into a soaking agent while the fried angelica dahurica slices are hot, adding deionized water until the mixed liquid just submerges the angelica dahurica slices, steaming and boiling for 4h under pressure, taking out after the juice is absorbed completely, taking out, airing to be dried from four to six times, putting into a high-voltage electric field dryer again, treating for 2h at 55 ℃, taking out, spraying a wetting agent on the surface of the angelica dahurica slices to keep the surface of the angelica dahurica slices in a wet state, standing for 15min, putting into the high-voltage electric field dryer, and treating for 2h at 65 ℃;
s5: pulverizing radix Angelicae Dahuricae, Saviae Miltiorrhizae radix, herba cistanches, Notopterygii rhizoma, fructus Xanthii, flos Magnoliae and herba Menthae, sequentially adding into a wall breaking machine, breaking wall, pulverizing, sieving, and coarse powder of 105 mesh; then placing the obtained coarse powder into an ultrafine pulverizer, pulverizing for 35min at 15 ℃, and pulverizing to 400 meshes to obtain ultrafine powder;
s6: granulating and sterilizing, namely preparing the ultrafine powder obtained in the step five into a soft material by using deionized water, putting the prepared soft material into a rotary granulator to obtain mixture granules, and putting the mixture granules into an ultraviolet sterilizer for sterilization and drying;
and S7, packaging and storing, subpackaging the mixture granules obtained in the step six under the aseptic condition to obtain the finished product, and storing in a ventilated and dry place.
The formula of the radix angelicae and salvia miltiorrhiza wall-broken decoction pieces comprises the following components: 23% of angelica dahurica, 13% of salvia miltiorrhiza, 8% of copper, 3% of notopterygium root, 5% of cocklebur fruit, 4% of biond magnolia flower, 5% of mint, 11% of soaking agent, 11% of impregnating compound and the balance of deionized water.
Wherein the soaking agent is ginger juice, and the soaking agent is a mixture of yellow wine and dark plum extract.
By carrying out component detection on the four groups of embodiments and selecting a group of angelica dahurica decoction pieces from the market for comparison, the detection results are as follows:
Figure BDA0002318363400000091
Figure BDA0002318363400000101
the experimental data in the table show that the fourth group of radix angelicae and radix salviae miltiorrhizae wall-broken decoction pieces have the best effects of promoting blood circulation, relieving pain and treating headache, so that the method has better popularization value.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (7)

1. A preparation method of radix angelicae and radix salviae miltiorrhizae wall-broken decoction pieces is characterized by comprising the following steps of: the preparation method comprises the following steps:
s1: quantitative weighing, namely weighing all the raw materials according to the components;
s2: cleaning the main materials, namely soaking the angelica dahurica and the salvia miltiorrhiza in clear water for 20-40 min, then soaking in 0.5% acetic acid solution for 1-2 h, taking out, and naturally drying;
s3: slicing and frying, namely slicing the angelica dahurica and the salvia miltiorrhiza which are dried in the step two, controlling the thickness of the slices to be 0.2cm, frying by adopting slow fire for 6-10 min until the surfaces of the slices after frying are not obviously changed in color and texture, and paying attention to that the angelica dahurica and the salvia miltiorrhiza are respectively and independently fried;
s4: steaming and drying, namely putting the fried angelica dahurica slices into a soaking agent while the fried angelica dahurica slices are hot, adding deionized water until the mixed liquid just submerges the angelica dahurica slices, steaming and boiling the angelica dahurica slices for 2 to 4 hours under pressure, taking out the angelica dahurica slices after the juice is completely absorbed, taking out the angelica dahurica slices, airing the angelica dahurica slices until the angelica dahurica slices are dried from four to six times, putting the angelica dahurica slices into a high-voltage electric field dryer again, treating the angelica dahurica slices for 2 hours at 55 ℃ with the electric field strength of 360kV/m, taking out the angelica dahurica slices, spraying a wetting agent on the surfaces of the angelica dahurica slices to keep the surfaces of the angelica;
s5: pulverizing radix Angelicae Dahuricae, Saviae Miltiorrhizae radix, herba cistanches, Notopterygii rhizoma, fructus Xanthii, flos Magnoliae and herba Menthae, sequentially adding into a wall breaking machine, breaking wall, pulverizing, sieving, and coarse powder of 105 mesh; then placing the prepared coarse powder into an ultrafine grinder, grinding for 20-35 min at 15 ℃, and grinding to 400 meshes to obtain ultrafine powder;
s6: granulating and sterilizing, namely preparing the ultrafine powder obtained in the step five into a soft material by using deionized water, putting the prepared soft material into a rotary granulator to obtain mixture granules, and putting the mixture granules into an ultraviolet sterilizer for sterilization and drying;
and S7, packaging and storing, subpackaging the mixture granules obtained in the step six under the aseptic condition to obtain the finished product, and storing in a ventilated and dry place.
2. The radix angelicae and radix salviae miltiorrhizae wall-broken decoction piece as claimed in claim 1, which is characterized in that; the formula of the B comprises the following components: 20-25% of angelica dahurica, 10-14% of salvia miltiorrhiza, 5-9% of copper, 1-4% of notopterygium root, 3-6% of cocklebur fruit, 2-5% of magnolia flower, 3-7% of mint, 8-12% of soaking agent, 9-13% of impregnating compound and the balance of deionized water.
3. The radix angelicae and radix salviae miltiorrhizae wall-broken decoction piece as claimed in claim 2, which is characterized in that: comprises 20% of angelica dahurica, 14% of salvia miltiorrhiza, 5% of copper, 4% of notopterygium root, 3% of cocklebur fruit, 5% of biond magnolia flower, 3% of mint, 8% of soaking agent, 9% of impregnating compound and the balance of deionized water.
4. The radix angelicae and radix salviae miltiorrhizae wall-broken decoction piece as claimed in claim 2, which is characterized in that: comprises 25% of angelica dahurica, 10% of salvia miltiorrhiza, 9% of copper, 1% of notopterygium root, 6% of cocklebur fruit, 2% of biond magnolia flower, 7% of mint, 12% of soaking agent, 13% of impregnating compound and the balance of deionized water.
5. The radix angelicae and radix salviae miltiorrhizae wall-broken decoction piece as claimed in claim 2, which is characterized in that: comprises 22% of angelica dahurica, 12% of salvia miltiorrhiza, 7% of copper, 2% of notopterygium root, 4% of cocklebur fruit, 3% of biond magnolia flower, 4% of mint, 9% of soaking agent, 10% of impregnating compound and the balance of deionized water.
6. The radix angelicae and radix salviae miltiorrhizae wall-broken decoction piece as claimed in claim 2, which is characterized in that: comprises 23% of angelica dahurica, 13% of salvia miltiorrhiza, 8% of copper, 3% of notopterygium root, 5% of cocklebur fruit, 4% of biond magnolia flower, 5% of mint, 11% of soaking agent, 11% of impregnating compound and the balance of deionized water.
7. The radix angelicae and radix salviae miltiorrhizae wall-broken decoction piece as claimed in claim 2, which is characterized in that: the soaking agent is ginger juice, and the soaking agent is yellow wine or dark plum extract or a mixture of the yellow wine and the dark plum extract.
CN201911287219.3A 2019-12-14 2019-12-14 Preparation method of radix angelicae and radix salviae miltiorrhizae wall-broken decoction pieces Pending CN111249335A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6413554B1 (en) * 2000-11-14 2002-07-02 Yong Il No Compositions for treatment of hyperlipidemia and angina pectoris
CN104306415A (en) * 2014-09-24 2015-01-28 苏州市天灵中药饮片有限公司 Preparation method of radix angelicae wall-broken decoction pieces
CN107823232A (en) * 2017-10-26 2018-03-23 安徽协和成药业饮片有限公司 A kind of preparation method of angelica dahurica decoction pieces

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6413554B1 (en) * 2000-11-14 2002-07-02 Yong Il No Compositions for treatment of hyperlipidemia and angina pectoris
CN104306415A (en) * 2014-09-24 2015-01-28 苏州市天灵中药饮片有限公司 Preparation method of radix angelicae wall-broken decoction pieces
CN107823232A (en) * 2017-10-26 2018-03-23 安徽协和成药业饮片有限公司 A kind of preparation method of angelica dahurica decoction pieces

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
冯建春: "《用药如用兵:中药配伍应用》", 31 July 2018, 中国中医药出版社 *
张春凤: "《中药炮制学》", 31 August 2015, 中国医药科技出版社 *

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