CN111248235A - 一种可杀灭冠状病毒的中西药复配消毒/抑菌剂及制备方法 - Google Patents
一种可杀灭冠状病毒的中西药复配消毒/抑菌剂及制备方法 Download PDFInfo
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Abstract
本发明公开了一种可杀灭冠状病毒的中西药复配消毒/抑菌剂的组方及制备方法。包括:复方中药提取液、二甲基苄基氯化铵与十八烷基二甲基氯化铵等季铵盐类衍生复合物,非离子表面活性剂、甘油、冰片、乙醇等。本发明的消毒/抑菌剂具有体外消毒、抑菌之功效,并可杀灭HCoV‑NL63、HCoV‑HKU1等冠状病毒,对常见致病菌的杀灭率高于次氯酸消毒剂,可用于物体表面、公共场所、设备、居家及办公环境、动物皮毛、植被、人体皮肤及粘膜的消毒、抑菌。
Description
技术领域
本发明涉及消毒剂、抑菌剂技术领域,具体公开一种可杀灭冠状病毒的中西药复配消毒/抑菌剂的组方及制备方法。
背景技术
2019新型冠状病毒(2019-nCoV)的传播方式为飞沫、气溶胶、粪口及接触传播,在温、湿度适宜环境中,2019-nCoV可以存活5天之久,极易造成人与人间的传播流行;切断传播途径,成为预防病毒传播流行的重要措施。目前首选的消毒剂是含氯药剂(包括次氯酸、二氧化氯等)及过氧乙酸等。但,含氯消毒剂具有强氧化性、刺激性及难降解性,还具有致癌、致突变的恶性作用,使用过程中易产生二噁英等有害物质;若高频率、高浓度使用,会对花草树木、水、土壤、农作物造成危害,直接或间接影响人体健康;长期单一、过度使用,易导致微生物基因突变和耐药产生;且不能与中药等有机成分配伍。此外,包括过氧乙酸,它们都具有强氧化性和腐蚀性,会对电器、设备造成损害,使用时多需要专业人员操作,不利于民用。
相对而言,某些新型的二甲基苄基氯化铵、十八烷基二甲基氯化铵等季铵盐类衍生复合物,不仅表现出较强的消杀治病病毒、细菌的效果,还更具安全性高、不易耐药、容易复配的优势;利用其所带负电荷,吸附于微生物膜表面,继而渗透、穿透、破坏膜结构,并使内部的酶、蛋白质变性、凝集,最终实现消杀效果;且更具表面活性剂优势,促进复配中多元组分(亲油、亲水)的充分溶解、扩散、透膜。冠状病毒的结构由四大类蛋白组成,分别是刺突蛋白(S),膜蛋白(M)、包膜蛋白(E)和核衣壳蛋白(N,让病毒粒子成型,包裹住核酸);而SME这三类蛋白则位于病毒外层,它们都定位在一层生物膜上面,生物膜类似一层油膜,一旦遇到季铵盐类表面活性剂就会被破坏;一旦这层膜被破坏,镶嵌在膜上的蛋白质的功能就会受损甚至完全丧失,而这些蛋白质是病毒进入宿主细胞所必须的,因此,新型的二甲基苄基氯化铵与十八烷基二甲基氯化铵等季铵盐类衍生物,对杀灭冠状病毒具有特异性。
科学证实,某些中药成分具有多靶点及显著的体外抗病毒、抗菌效果,可抑制病源复制、阻断病源传播,并由于组方中的多元成分协同作用,不易产生耐药。将中、西药剂结合配伍,是最新一代抑菌/消毒剂的发展趋势。
虽然,应用中成药治疗2019-nCoV感染者的临床有效性和机理还未完全被科学证实;但,在体外实验中,某些中药成分可有效抑制多种病毒(包括冠状病毒)的事实,已被科学证实。
本专利旨在研发最新一代可多靶点抗病毒(包括冠状病毒)的新型抑菌、消毒剂,以复方中药组方与新型的季铵盐类衍生复合物物配伍,发挥中药成分多靶点、不易产生耐药、环保、安全性及稳定性好的特点;充分促进中、西药协同作用、减毒增效,使体外消杀效果更高效、安全、广谱及更加环保;本药剂可制备成抑菌/消毒湿巾、喷剂等多种剂型,用于环境、物表、设备、器皿、手、皮肤及粘膜等的抑菌/消毒,适应不同人群和生产、生活各领域需求。
发明内容
本发明提供的中西药复配消毒/抑菌剂,其按质量/体积百分比的处方组成如下(见表1):
表1 处方组成
其中,复方中药提取液中的药材,按重量分数计由以下组分制成:大黄1~20份,姜黄1~20份,苦参1~20份,黄柏1~10份,艾叶1~10份,金银花1~10份,藿香1~10份。
优选地,按质量/体积百分比算,由以下组分制成:复方中药提取液30.0%;季铵盐类复合物1.5%;表面活性剂2.5%;甘油1.0%;冰片1.0% ;苯甲酸钠0.5%;香精0.5%;乙醇3.0%;去离子水60.0%。其中,所述复方中药提取液,按重量份数计由以下组分制成:大黄15份,姜黄15份,苦参15份,黄柏10份,艾叶8份,金银花10份,藿香8份。
优选地,所述表面活性剂为吐温80、聚氧乙烯脂肪酸酯、泊洛沙姆中的一种或几种。
优选地,所述香精为水溶性香精。
本发明同时提供了:可杀灭冠状病毒的,安全、环保的中西药复配消毒/抑菌剂制备方法,具体包括以下几个步骤:
步骤1,按复方中药提取液组方的重量份数称取以下组分:大黄1~20份,姜黄1~20份,苦参1~20份,黄柏1~10份,艾叶1~10份,金银花1~10份,藿香1~10份。
步骤2,将步骤1称取的药材混合均匀,第一次加入相当于其总重量2~10倍量的去离子水,60℃~85℃回流提取1.0~3.0h,收取挥发油及煎液,将煎液过滤,收集第一次滤液;滤渣加入相当于其总重量5~10倍量的去离子水,60℃~85℃继续回流提取1.0~3.0h,收取挥发油及煎液,将煎液过滤,收集第二次滤液;合并两次滤液,浓缩成常温下相对密度为1.05~1.20的溶液,备用。同时,将两次收集的挥发油合并,备用。
步骤3,将步骤2中得到的浓缩液加入大孔树脂(由D101、BXDA-7两种树脂组成,质量比例为:D101:BXDA-7 = 6:4)吸附柱中进行吸附洗脱,洗脱剂为质量/体积百分比为5~10%的乙醇溶液,洗脱流速为1mL/min,收集洗脱液,备用。
步骤4,将步骤3中得到的洗脱液浓缩至1mg/mL,再将步骤2中收集的挥发油加入浓缩后的洗脱液中,加入表面活性剂,搅拌均匀,得中药提取液。
步骤5,按上述表1中的处方组成,准确称取化学原料,包括二甲基苄基氯化铵0.02-1.0% 、十八烷基二甲基氯化铵0.02-1.0%、二癸基甲基聚丙酸铵0.01-0.5%。将以上化学原料混合,用20%浓度的乙醇溶液溶解并制成近饱和溶液,混匀,再加入等体积的去离子水,混匀,过滤,取滤液,备用。
步骤6,将以上4、5步制得的药液,在常温条件下混合均匀,加入甘油0.5-3.0%、冰片0.5-3.0%、苯甲酸钠0.2-1.0%、香精0.1-1.0%,缓慢混匀,过滤,加去离子水到满量,再用适量乳酸溶液调至pH5-6,分装,即得本品。
相比于现有技术及产品,本发明的优势、特点为:
①与现有的含氯消毒剂相比,本次发明本品不仅表现出较强的杀灭效果,既可以杀灭治病病毒(包括冠状病毒)、又可以有效杀灭治病细菌,还具有更高的安全性、环保性。
②本品的主要成分为复方中药,具有多靶点、不易产生耐药、更环保、更安全性的优点;充分促进了中、西药的协同杀灭作用,实现了减毒增效。
③本品的质量稳定、杀灭效果持久。
④本品可针对性地杀灭冠状病毒,有效阻断冠状病毒的传播、扩散。
具体实施方式:
为了使本领域技术人员更好地理解本发明的技术方案能予以实施,下面结合具体实施例对本发明作进一步说明,但所举实施例不作为对本发明的限定。
实施例1
一种可以杀灭冠状病毒的安全、环保的中西药复配消毒/抑菌剂,其按质量/体积百分比的处方组成如下(见表2):
表2 实施例1的处方组成
具体按照以下步骤进行制备:
步骤1,按复方中药组方的重量份数称取以下组分:大黄20份,姜黄20份,苦参20份,黄柏10份,艾叶10份,金银花5份,藿香10份。
步骤2,将步骤1称取的药材混合均匀,第一次加入相当于其总重量10倍量的去离子水,75℃~85℃回流提取2.0h,收取挥发油及煎液,将煎液过滤,收集第一次滤液;滤渣加入相当于其总重量10倍量的去离子水,75℃~85℃继续回流提取2.0h,收取挥发油及煎液,将煎液过滤,收集第二次滤液;合并两次滤液,浓缩成常温下相对密度为1.05~1.20的溶液,备用。同时,将两次收集的挥发油合并,备用。
步骤3,将步骤2中得到的浓缩液加入大孔树脂吸附柱中进行吸附洗脱,洗脱剂为质量/体积百分比为10%的乙醇溶液,洗脱流速为1mL/min,收集洗脱液,备用。
步骤4,将步骤3中得到的洗脱液浓缩至1mg/mL,再将步骤2中收集的挥发油加入浓缩后的洗脱液中,加入表面活性剂,搅拌均匀,得中药提取液。
步骤5,按上述表1中的处方组成,准确称取化学原料,包括二甲基苄基氯化铵0.1% 、十八烷基二甲基氯化铵0.1%、二癸基甲基聚丙酸铵0.2%。将以上化学原料混合,用20%浓度的乙醇溶液溶解并制成近饱和溶液,混匀,再加入等体积的去离子水,混匀,过滤,取滤液,备用。
步骤6,将以上4步制得中药提取液按30%浓度加入,在常温条件下,与5步制得的药液混合均匀,加入甘油1.0%、冰片1.0%、苯甲酸钠0.5%、香精0.5%,缓慢混匀,过滤,加去离子水到满量,再用适量乳酸溶液调至pH5-6,分装,即得本品。
实施例2
一种可以杀灭冠状病毒的安全、环保的中西药复配消毒/抑菌剂,其按质量/体积百分比的处方组成如下(见表3):
表3 实施例2的处方组成
具体按照以下步骤进行制备:
步骤1,按复方中药组方的重量份数称取以下组分:大黄15份,姜黄15份,苦参15份,黄柏10份,艾叶8份,金银花10份,藿香8份。
步骤2,将步骤1称取的药材混合均匀,第一次加入相当于其总重量10倍量的去离子水,65℃~80℃回流提取3.0h,收取挥发油及煎液,将煎液过滤,收集第一次滤液;滤渣加入相当于其总重量8倍量的去离子水,65℃~80℃继续回流提取3.0h,收取挥发油及煎液,将煎液过滤,收集第二次滤液;合并两次滤液,浓缩成常温下相对密度为1.05~1.20的溶液,备用。同时,将两次收集的挥发油合并,备用。
步骤3,将步骤2中得到的浓缩液加入大孔树脂吸附柱中进行吸附洗脱,洗脱剂为质量/体积百分比为10%的乙醇溶液,洗脱流速为1mL/min,收集洗脱液,备用。
步骤4,将步骤3中得到的洗脱液浓缩至1mg/mL,再将步骤2中收集的挥发油加入浓缩后的洗脱液中,加入表面活性剂,搅拌均匀,得中药提取液。
步骤5,按上述表1中的处方组成,准确称取化学原料,包括二甲基苄基氯化铵0.05% 、十八烷基二甲基氯化铵0.05%、二癸基甲基聚丙酸铵0.1%。将以上化学原料混合,用20%浓度的乙醇溶液溶解并制成近饱和溶液,混匀,再加入等体积的去离子水,混匀,过滤,取滤液,备用。
步骤6,将以上4步制得中药提取液按30%浓度加入,在常温条件下,与5步制得的药液混合均匀,加入甘油2.0%、冰片2.0%、苯甲酸钠1.0%、香精2.0%,缓慢混匀,过滤,加去离子水到满量,再用适量乳酸溶液调至pH5-6,分装,即得本品。
实施例3
一种可以杀灭冠状病毒的安全、环保的中西药复配消毒/抑菌剂,其按质量/体积百分比的处方组成如下(见表4):
表4 实施例3的处方组成
具体按照以下步骤进行制备:
步骤1,按复方中药组方的重量份数称取以下组分:大黄5份,姜黄5份,苦参5份,黄柏10份,艾叶10份,金银花10份,藿香10份。
步骤2,将步骤1称取的药材混合均匀,第一次加入相当于其总重量8倍量的去离子水,60℃~75℃回流提取3.0h,收取挥发油及煎液,将煎液过滤,收集第一次滤液;滤渣加入相当于其总重量5倍量的去离子水,60℃~75℃继续回流提取2.0h,收取挥发油及煎液,将煎液过滤,收集第二次滤液;合并两次滤液,浓缩成常温下相对密度为1.05~1.20的溶液,备用。同时,将两次收集的挥发油合并,备用。
步骤3,将步骤2中得到的浓缩液加入大孔树脂吸附柱中进行吸附洗脱,洗脱剂为质量/体积百分比为10%的乙醇溶液,洗脱流速为1mL/min,收集洗脱液,备用。
步骤4,将步骤3中得到的洗脱液浓缩至1mg/mL,再将步骤2中收集的挥发油加入浓缩后的洗脱液中,加入表面活性剂,搅拌均匀,得中药提取液。
步骤5,按上述表1中的处方组成,准确称取化学原料,包括二甲基苄基氯化铵1.0% 、十八烷基二甲基氯化铵1.0%、二癸基甲基聚丙酸铵0.4%。将以上化学原料混合,用20%浓度的乙醇溶液溶解并制成近饱和溶液,混匀,再加入等体积的去离子水,混匀,过滤,取滤液,备用。
步骤6,将以上4步制得中药提取液按30%浓度加入,在常温条件下,与5步制得的药液混合均匀,加入甘油3.0%、冰片3.0%、苯甲酸钠1.0%、香精0.3%,缓慢混匀,过滤,加去离子水到满量,再用适量乳酸溶液调至pH5-6,分装,即得本品。
将上述各实施例得到的消毒剂样品分别进行感官、理化指标、有效期及毒理学指标检测。
各实施例得到的消毒剂样品的感官、理化指标、有效期及毒理学指标检测结果见表5。
表5 实施例1、2、3样品的感官、理化性质、有效期及毒理学指标的检测结果
将上述各实施例得到的消毒剂样品分别进行抗冠状病毒、抗禽流感病毒、抗致病菌、稳定性考察及相关指标检测。
各实施例得到的消毒剂样品的抗冠状病毒(以低致病性的人冠状病毒HCoV-NL63、HCoV-HKU1为对象)检测结果见表6、7。
表6 实施例1、2、3样品对HCoV-NL63病毒的杀灭率(%)(n=3)
1:10 | 1:25 | 1:50 | 1:100 | 1:250 | |
对照品(次氯酸消毒剂400ppm) | 100 | 94.68±0.18 | 64.68±0.22 | 55.30±0.12 | 0 |
实施例1 | 100 | 100* | 96.68±0.18* | 91.30±0.26* | 46.65±0.11* |
实施例2 | 100 | 100* | 100* | 97.87±0.23* | 50.07±0.33* |
实施例3 | 100 | 100* | 100* | 98.36±0.08* | 44.10±0.17* |
注:* 与对照品比较P<0.05
表7 实施例1、2、3样品对HCoV-HKU1病毒的杀灭率(%)(n=3)
1:10 | 1:25 | 1:50 | 1:100 | 1:250 | |
对照品(次氯酸消毒剂400ppm) | 100 | 88.45±0.53 | 61.27±0.24 | 34.87±0.19 | 0 |
实施例1 | 100 | 100* | 90.53±0.35* | 58.28±0.26* | 31.67±0.39* |
实施例2 | 100 | 100* | 100* | 83.10±0.26* | 46.10±0.17* |
实施例3 | 100 | 100* | 90.04±0.32* | 54.77±0.28* | 26.05±0.45* |
注:* 与对照品比较P<0.05
各实施例消毒剂样品抗禽流感病毒检测结果见表8。
表8实施例1、2、3不同稀释倍数样品对禽流感病毒的杀灭效果(n=3)
注:* 与对照品比较P<0.05
各实施例消毒剂按1:10稀释后的样品抗金黄色葡萄球菌考察结果见表9。
表9 本品实施例1、2、3对金黄色葡萄球菌的杀灭率
样品 时间 | 5分钟 | 10分钟 | 20分钟 |
对照品(次氯酸消毒剂400ppm) | 99.20% | 99.80% | 99.99% |
实施例1 | 99.75% | 99.99% | 99.99% |
实施例2 | 99.99% | 99.99% | 99.99% |
实施例3 | 99.80% | 99.99% | 99.99% |
各实施例消毒剂按1:10稀释后的样品抗日沟维肠杆菌考察结果见表10。
表10 本品实施例1、2、3对日沟维肠杆菌的杀灭率
样品 时间 | 5分钟 | 10分钟 | 20分钟 |
对照品(次氯酸消毒剂400ppm) | 99.55% | 99.80% | 99.99% |
实施例1 | 99.90% | 99.95% | 99.99% |
实施例2 | 9999% | 99.99% | 99.99% |
实施例3 | 99.59% | 99.90% | 99.99% |
各实施例消毒剂按1:10稀释后的样品抗白色念珠菌考察结果见表11。
表11 本品实施例1、2、3对白色念珠菌的杀灭率
样品 时间 | 5分钟 | 10分钟 | 20分钟 |
对照品(次氯酸消毒剂400ppm) | 99.80% | 99.99% | 99.99% |
实施例1 | 99.99% | 99.99% | 99.99% |
实施例2 | 99.99% | 99.99% | 99.99% |
实施例3 | 99.29% | 99.99% | 99.99% |
各实施例得到的消毒剂样品的稳定性考察结果(见表12、13)。
表12 实施例1、2、3样品在常温条件下的稳定性(姜黄素、大黄素含量)测定结果
表13 实施例1、2、3样品的低温抗冻性考察结果
5℃ | 0℃ | -5℃ | -10℃ | |
实施例1 | 澄明液体 | 澄明液体 | 澄明液体 | 澄明液体 |
实施例2 | 澄明液体 | 澄明液体 | 澄明液体 | 澄明液体 |
实施例3 | 澄明液体 | 澄明液体 | 澄明液体 | 澄明液体 |
针对本发明的实施例1、2、3,实施了系统性的实验考察,证实了其具有良好的安全性;证实了其杀灭治病病毒(包括冠状病毒)及常见致病菌细菌的有效性,均优于已上市的消毒剂;同时,通过科学实验,也证实了其具有较好的稳定性。
Claims (6)
1.一种可杀灭冠状病毒的中西药复配消毒/抑菌剂,其特征在于,按质量/体积百分比计,由以下组分制成:复方中药提取液10-60%;季铵盐类衍生复合物0.05-2.5%;表面活性剂0.5-5.0%;甘油0.5-3.0%;冰片0.5-3.0% ;苯甲酸钠0.2-1.0%;香精0.1-1.0%;乙醇0.1-10.0%;去离子水15-85%;其中,所述复方中药提取液按重量份数计,由以下组分制成:大黄1~20份,姜黄1~20份,苦参1~20份,黄柏1~10份,艾叶1~10份,金银花1~10份,藿香1~10份。
2.根据权利要求1所述的一种可杀灭冠状病毒的中西药复配消毒/抑菌剂,其特征在于,所述表面活性剂为吐温80、聚氧乙烯脂肪酸酯、泊洛沙姆中的一种或几种。
3.根据权利要求1所述的一种可杀灭冠状病毒的中西药复配消毒/抑菌剂,其特征在于,所述香精为水溶性香精。
4.根据权利要求1所述的一种可杀灭冠状病毒的中西药复配消毒/抑菌剂,其特征在于,该消毒/抑菌剂可有效杀灭HCoV-NL63、HCoV-HKU1等冠状病毒,稀释25倍时,对HCoV-NL63、HCoV-HKU1等冠状病毒的杀灭率仍可达到100%。
5.根据权利要求1所述的一种可杀灭冠状病毒的中西药复配消毒/抑菌剂,其特征在于,其具体制备方法包括以下几个步骤:
步骤1,按复方中药提取液组方的重量份数称取以下组分:大黄1~20份,姜黄1~20份,苦参1~20份,黄柏1~10份,艾叶1~10份,金银花1~10份,藿香1~10份;
步骤2,将步骤1称取的药材混合均匀,第一次加入相当于其总重量2~10倍量的去离子水,60℃~85℃回流提取1.0~3.0h,收取挥发油及煎液,将煎液过滤,收集第一次滤液;滤渣加入相当于其总重量5~10倍量的去离子水,60℃~85℃继续回流提取1.0~3.0h,收取挥发油及煎液,将煎液过滤,收集第二次滤液;合并两次滤液,浓缩成常温下相对密度为1.05~1.20的溶液备用,同时将两次收集的挥发油合并备用;
步骤3,将步骤2中得到的浓缩液加入大孔树脂吸附柱中进行吸附洗脱,洗脱剂为质量/体积百分比为5~10%的乙醇溶液,洗脱流速为1mL/min,收集洗脱液,备用;
步骤4,将步骤3中得到的洗脱液浓缩至1mg/mL,再将步骤2中收集的挥发油加入浓缩后的洗脱液中,加入表面活性剂,搅拌均匀,得中药提取液;
步骤5,按上述表1中的处方组成,准确称取化学原料,包括二甲基苄基氯化铵0.02-1.0% 、十八烷基二甲基氯化铵0.02-1.0%、二癸基甲基聚丙酸铵0.01-0.5%,将以上化学原料混合,用20%浓度的乙醇溶液溶解并制成近饱和溶液,混匀,再加入等体积的去离子水,混匀,过滤,取滤液,备用;
步骤6,将以上4、5步制得的药液,在常温条件下混合均匀,加入甘油0.5-3.0%、冰片0.5-3.0%、苯甲酸钠0.2-1.0%、香精0.1-1.0%,缓慢混匀,过滤,加去离子水到满量,再用适量乳酸溶液调至pH5-6,分装即得本品。
6.根据权利要求6所述的一种可杀灭冠状病毒的中西药复配消毒/抑菌剂的制备方法,其特征在于:步骤3中所用的大孔树脂为D101与BXDA-7两种树脂的混合物,质量比例为D101:BXDA-7 = 6:4。
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