CN111246835B - 包含辛酸的非皂液体清洁剂组合物 - Google Patents
包含辛酸的非皂液体清洁剂组合物 Download PDFInfo
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- CN111246835B CN111246835B CN201880066013.5A CN201880066013A CN111246835B CN 111246835 B CN111246835 B CN 111246835B CN 201880066013 A CN201880066013 A CN 201880066013A CN 111246835 B CN111246835 B CN 111246835B
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- Prior art keywords
- surfactant
- acid
- composition
- octanoic acid
- nonionic
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- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 title claims abstract description 98
- 239000000203 mixture Substances 0.000 title claims abstract description 73
- 239000007788 liquid Substances 0.000 title claims description 15
- 229960002446 octanoic acid Drugs 0.000 title description 45
- 239000000344 soap Substances 0.000 title description 11
- 239000003599 detergent Substances 0.000 title description 10
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 title description 5
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 claims abstract description 44
- 239000004094 surface-active agent Substances 0.000 claims description 25
- 239000003945 anionic surfactant Substances 0.000 claims description 18
- 150000007524 organic acids Chemical class 0.000 claims description 18
- 239000002736 nonionic surfactant Substances 0.000 claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 239000003242 anti bacterial agent Substances 0.000 claims description 12
- XMIIGOLPHOKFCH-UHFFFAOYSA-N 3-phenylpropionic acid Chemical compound OC(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-N 0.000 claims description 10
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 claims description 8
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 7
- 239000002280 amphoteric surfactant Substances 0.000 claims description 7
- 229960005323 phenoxyethanol Drugs 0.000 claims description 7
- 239000005844 Thymol Substances 0.000 claims description 4
- WUOACPNHFRMFPN-UHFFFAOYSA-N alpha-terpineol Chemical compound CC1=CCC(C(C)(C)O)CC1 WUOACPNHFRMFPN-UHFFFAOYSA-N 0.000 claims description 4
- SQIFACVGCPWBQZ-UHFFFAOYSA-N delta-terpineol Natural products CC(C)(O)C1CCC(=C)CC1 SQIFACVGCPWBQZ-UHFFFAOYSA-N 0.000 claims description 4
- OEIJHBUUFURJLI-UHFFFAOYSA-N octane-1,8-diol Chemical compound OCCCCCCCCO OEIJHBUUFURJLI-UHFFFAOYSA-N 0.000 claims description 4
- 229910052709 silver Inorganic materials 0.000 claims description 4
- 239000004332 silver Substances 0.000 claims description 4
- 229940116411 terpineol Drugs 0.000 claims description 4
- 229960000790 thymol Drugs 0.000 claims description 4
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 3
- 150000001413 amino acids Chemical class 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 claims description 3
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 2
- 229940009188 silver Drugs 0.000 claims description 2
- 125000005526 alkyl sulfate group Chemical group 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 abstract description 5
- 239000000271 synthetic detergent Substances 0.000 abstract description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 33
- -1 triclocarbon Chemical compound 0.000 description 24
- 238000009472 formulation Methods 0.000 description 14
- 125000000217 alkyl group Chemical group 0.000 description 13
- 125000004432 carbon atom Chemical group C* 0.000 description 11
- 230000000694 effects Effects 0.000 description 11
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 10
- 150000001875 compounds Chemical class 0.000 description 8
- 235000014113 dietary fatty acids Nutrition 0.000 description 8
- 239000000194 fatty acid Substances 0.000 description 8
- 229930195729 fatty acid Natural products 0.000 description 8
- 241000894006 Bacteria Species 0.000 description 7
- 230000000845 anti-microbial effect Effects 0.000 description 7
- 150000004665 fatty acids Chemical class 0.000 description 7
- 239000008149 soap solution Substances 0.000 description 7
- 241000588724 Escherichia coli Species 0.000 description 6
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 6
- 230000003115 biocidal effect Effects 0.000 description 6
- 235000005985 organic acids Nutrition 0.000 description 6
- 239000005711 Benzoic acid Substances 0.000 description 5
- 229910019142 PO4 Inorganic materials 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 235000010233 benzoic acid Nutrition 0.000 description 5
- 235000021317 phosphate Nutrition 0.000 description 5
- GHVNFZFCNZKVNT-UHFFFAOYSA-N Decanoic acid Natural products CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 4
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 4
- 125000003342 alkenyl group Chemical group 0.000 description 4
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 description 4
- 229940073507 cocamidopropyl betaine Drugs 0.000 description 4
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 4
- 238000005187 foaming Methods 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 235000010199 sorbic acid Nutrition 0.000 description 4
- 239000004334 sorbic acid Substances 0.000 description 4
- 229940075582 sorbic acid Drugs 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 150000007513 acids Chemical class 0.000 description 3
- 239000001361 adipic acid Substances 0.000 description 3
- 235000011037 adipic acid Nutrition 0.000 description 3
- 150000008051 alkyl sulfates Chemical class 0.000 description 3
- 125000002947 alkylene group Chemical group 0.000 description 3
- 150000007942 carboxylates Chemical class 0.000 description 3
- 150000001768 cations Chemical class 0.000 description 3
- 235000019864 coconut oil Nutrition 0.000 description 3
- 239000003240 coconut oil Substances 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- SMVRDGHCVNAOIN-UHFFFAOYSA-L disodium;1-dodecoxydodecane;sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O.CCCCCCCCCCCCOCCCCCCCCCCCC SMVRDGHCVNAOIN-UHFFFAOYSA-L 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000000693 micelle Substances 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 230000003381 solubilizing effect Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000002888 zwitterionic surfactant Substances 0.000 description 3
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 2
- GYSCBCSGKXNZRH-UHFFFAOYSA-N 1-benzothiophene-2-carboxamide Chemical compound C1=CC=C2SC(C(=O)N)=CC2=C1 GYSCBCSGKXNZRH-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-M Aminoacetate Chemical compound NCC([O-])=O DHMQDGOQFOQNFH-UHFFFAOYSA-M 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
- 241000192125 Firmicutes Species 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
- QQONPFPTGQHPMA-UHFFFAOYSA-N Propene Chemical group CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 2
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 125000002252 acyl group Chemical group 0.000 description 2
- 150000001335 aliphatic alkanes Chemical class 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- 125000000129 anionic group Chemical group 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- 229940098691 coco monoethanolamide Drugs 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 239000004088 foaming agent Substances 0.000 description 2
- 229930195712 glutamate Natural products 0.000 description 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 2
- ACXGEQOZKSSXKV-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O.CCCCCCCC(O)=O ACXGEQOZKSSXKV-UHFFFAOYSA-N 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 238000005192 partition Methods 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 229930015704 phenylpropanoid Natural products 0.000 description 2
- 150000002995 phenylpropanoid derivatives Chemical class 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 description 2
- 229910052698 phosphorus Inorganic materials 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 230000003334 potential effect Effects 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 238000000638 solvent extraction Methods 0.000 description 2
- AGGIJOLULBJGTQ-UHFFFAOYSA-N sulfoacetic acid Chemical class OC(=O)CS(O)(=O)=O AGGIJOLULBJGTQ-UHFFFAOYSA-N 0.000 description 2
- 150000003871 sulfonates Chemical class 0.000 description 2
- 125000004434 sulfur atom Chemical group 0.000 description 2
- OSDLLIBGSJNGJE-UHFFFAOYSA-N 4-chloro-3,5-dimethylphenol Chemical compound CC1=CC(O)=CC(C)=C1Cl OSDLLIBGSJNGJE-UHFFFAOYSA-N 0.000 description 1
- 229940100484 5-chloro-2-methyl-4-isothiazolin-3-one Drugs 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical class S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical group [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 229920000604 Polyethylene Glycol 200 Polymers 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- NENOAJSZZPODGJ-OIMNJJJWSA-N [(2r)-2-[(2r,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] octanoate Chemical compound CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NENOAJSZZPODGJ-OIMNJJJWSA-N 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 125000004181 carboxyalkyl group Chemical group 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- DHNRXBZYEKSXIM-UHFFFAOYSA-N chloromethylisothiazolinone Chemical compound CN1SC(Cl)=CC1=O DHNRXBZYEKSXIM-UHFFFAOYSA-N 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 239000007859 condensation product Substances 0.000 description 1
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical class CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 1
- MJPNHDFDRIHUNX-UHFFFAOYSA-N dodecanoyl dodecanoate;sulfuric acid Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC(=O)OC(=O)CCCCCCCCCCC MJPNHDFDRIHUNX-UHFFFAOYSA-N 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000021588 free fatty acids Nutrition 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 125000001165 hydrophobic group Chemical group 0.000 description 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 150000002688 maleic acid derivatives Chemical class 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
- MPQXHAGKBWFSNV-UHFFFAOYSA-N oxidophosphanium Chemical group [PH3]=O MPQXHAGKBWFSNV-UHFFFAOYSA-N 0.000 description 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-O phosphonium Chemical compound [PH4+] XYFCBTPGUUZFHI-UHFFFAOYSA-O 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 125000004437 phosphorous atom Chemical group 0.000 description 1
- 239000011574 phosphorus Chemical group 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 150000003138 primary alcohols Chemical class 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Substances CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000000518 rheometry Methods 0.000 description 1
- 150000003333 secondary alcohols Chemical class 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 150000003890 succinate salts Chemical class 0.000 description 1
- DIORMHZUUKOISG-UHFFFAOYSA-N sulfoformic acid Chemical compound OC(=O)S(O)(=O)=O DIORMHZUUKOISG-UHFFFAOYSA-N 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical group OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- CXVGEDCSTKKODG-UHFFFAOYSA-N sulisobenzone Chemical compound C1=C(S(O)(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC=CC=C1 CXVGEDCSTKKODG-UHFFFAOYSA-N 0.000 description 1
- 229960000368 sulisobenzone Drugs 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical class NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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Abstract
本发明涉及pH为4.5至5.5的合成洗涤剂基组合物,其中预料不到地发现辛酸的使用增强细菌杀灭。
Description
技术领域
本发明涉及具有增强的抗细菌活性的非皂(有时称为合成洗涤剂(syndet或synthetic detergent))基液体清洁剂。特别地,已经发现,向温和pH(pH为4.5至5.5,优选4.5至5.1,尤其是4.5至4.9)的液体合成洗涤剂组合物中加入辛酸(辛酸)在该pH范围下令人惊奇地增强了抗细菌活性。
背景技术
个人清洁产品,包括液体,在卫生中起到重要作用。通常通过使用抗细菌剂,如酚醛抗微生物化合物(例如,三氯生,三氯卡班(triclocarbon)、PCMX)、非酚醛抗微生物化合物(例如,季铵盐)和具有游离金属离子(例如Ag+、Zn2+、Cu2+)的化合物)递送卫生。
然而,在其在温和pH范围(例如,4.5至5.5,或4.5至5.1,特别是4.5至5.0或4.5至4.9;具有低于4.5的pH的产品通常被认为是严苛的(harsh)且能够对皮肤造成一些损伤)中的组合物中,难以提供增强的抗细菌活性,特别是如果希望避免使用抗细菌剂。例如,已经有涉及抗细菌剂的使用、它们对于环境的潜在作用,以及它们在促进抗药性方面的潜在作用的顾虑。抗细菌剂面临来自监管机构的日益增加的详细审查,更不用说在生产工艺期间增加的材料处理和成本。因此,提供抗细菌作用而不使用传统抗细菌剂会是极为有益的。
另外,难以实现对抗革兰氏阳性菌和革兰氏阴性菌两者的广泛作用;而且,难以实现快速作用(在20秒或更短,特别地在10秒或更短内的作用)。
在基于合成表面活性剂的液体清洁剂(特别是基于50%或更多阴离子表面活性剂如烷基硫酸盐的那些)中,例如,现已发现在4.5至5.5,优选4.5至5.1,特别是4.5至4.9的pH范围下,加入C8脂肪酸可以提供快速的、广泛的(broad-based)抗细菌作用。虽然传统抗细菌剂如上述那些可以稍微改善单独C8脂肪酸的作用,但是甚至在不含传统抗细菌剂的组合物中看到了显著的改善。
当辛酸与某些有机酸(例如,苯基丙酸)组合时,可以进一步增强单独的(再次地,甚至假设不存在传统抗细菌剂)辛酸(caprylic acid)(也称为辛酸(octanoic acid))的作用。
当辛酸与pKa大于4.0但小于5.0的其它有机酸(例如,苯甲酸、山梨酸和本文定义的其它有机酸)组合时,所述作用也可以被进一步增强。上文刚提到的苯基丙酸与辛酸一起工作在功效方面特别好。其具有pKa>4.5;以及具有相对高的LogP(在水相和亲脂相之间的分配系数,一般使用辛醇和水测量)和高水溶解度两者。这些参数确保有机酸的可用性在pH4.5至约4.9下相对高(由于其高pKa和水溶解度),同时具有足够分配到细菌膜中的疏水性。而且,当与本文定义的某些非离子分子组合时,该作用可得到增强。
在Mitrinova等人的2013年的文章(“Efficient control of the Rheologicaland Surface Properties of Surfactant Solutions Containing C8to C18 Fatty Acidsas Co-surfactants”,2013年6月11日,Langmuir)中,公开的组合物包含月桂酰醚硫酸钠(SLES)和椰油酰胺丙基甜菜碱(CAPB)表面活性剂体系和进一步包含C8至C18脂肪酸;该参考文献描述了这些脂肪酸对表面活性剂的流变学的期望影响。没有更具体地认识到C8在这样的体系中的使用及其对抗细菌功效的影响,特别是在具有特定温和pH范围的组合物中。没有具体讨论pH和在某些pH范围下的抗细菌作用。
在Georgieva等人的2016年的文章(“Synergistic Growth of Giant WormlikeMicelles in Ternary Mixed Surfactant Solutions:Effect of Octanoic Acid”),2016,Langmuir)中,提及SLES/CAPB/辛酸体系的最小pH为约5.1。没有提及更低的pH和/或抗细菌有效性。
P&G的EP 044 582公开了其中使用比率为1:3至3:1的游离脂肪酸和脂肪烷醇酰胺的特定组合作为用于阴离子表面活性剂的增泡剂(lather booster)的组合物。尽管椰子油脂肪酸公开为0.2重量%的含量(实施例1),但已知辛酸包含不超过约10%的椰子油(参见,例如,原始状态的椰子油的脂肪酸组成,http://www.thevirgincoconutoil.com/articleitem.php?articleid=163)。因此,椰子油混合物包含不超过0.2%的辛酸。
发明内容
本发明涉及非皂(即,基于合成表面活性剂的)液体组合物。特别地,其涉及辛酸在温和pH(例如,pH 4.5至5.5,优选4.5至5.1,特别是4.5至5.0或4.5至4.9)液体中的用途。优选地,辛酸用于在不存在其它抗细菌(AB)剂的情况下,提高对抗革兰氏阴性菌和革兰氏阳性菌两者的抗微生物功效。
更特别地,本发明包含:
1)5至25重量%,优选8至20%的阴离子表面活性剂(例如,烷基硫酸盐,如月桂基醚硫酸钠SLES;或基于氨基酸的表面活性剂,如谷氨酸盐或甘氨酸盐,以及牛磺酸盐);该清洁剂可用于细菌清除应用,如手洗液或发泡剂。
低表面活性剂制剂特别好地起作用,其中优选的表面活性剂水平为5至8%,优选6.0至7.5重量%;由于较少分配到胶束中,辛酸的可用性在低表面活性剂下最佳。实施例7和8为含有相对低表面活性剂的具有高发泡性质的清洁剂组合物的实例。
非皂清洁剂特别适用于应用如液体洗手皂,发泡液体洗手皂、液体沐浴液、沐浴凝胶、剥落清洁剂(exfoliating cleanser)、洗发香波、清洁擦拭物(cleaning wipe)或工业皂。该制剂可用于或用作皂组合物的基质以通过清洁或处理有需要的受试者的皮肤和/或毛发(毛皮)而预防和治疗多种多样的微生物感染。
2)任选的非离子表面活性剂(例如,0至5%,优选0.5至4重量%),优选烷基酰胺基烷醇胺(例如,烷醇酰胺,如椰油单乙醇酰胺);
3)任选的两性和/或两性离子表面活性剂(尽管酰胺基甜菜碱优选地被最小化(例如,2重量%或更少,优选1重量%,更优选0.01至0.5%)或优选地完全不存在);酰胺基甜菜碱的存在抑制了辛酸在制剂抗微生物功效方面的提高作用(参见实施例中实施例4相对于实施例2)
4)0.5至3%,特别是1.0至3%,特别是1.1或1.2或1.3至3%的辛酸,
其中所述组合物的pH为4.5至5.5,优选4.5至5.1,更优选4.5至5.0或4.5至4.9。
预料不到地,已经发现当在某些很小的水平使用时,辛酸提高了广谱抗细菌活性(例如,对抗革兰氏阳性菌和革兰氏阴性菌两者);尽管少量的传统抗细菌活性物可以稍微提高C8作为活性物的活性,但是C8甚至在不存在抗细菌活性物的情况下是高度有效的;这样的抗细菌活性物在制剂中是任选的,通常以0至0.4%,优选0至0.2%,更优选0.1至0.2%的水平存在。
可以使用的抗细菌活性物的实例包括活性物如银、苯氧基乙醇及其混合物。其它活性物包括百里酚、萜品醇和混合物;后者当然可以单独使用(或者,作为百里酚和萜品醇的混合物);或者与银、苯氧基乙醇或其它已知的抗细菌物或这样的已知抗细菌物的混合物组合。
在一个形式中,当辛酸与具有在4.0至5.0之间的pKa、大于0的logP和大于0.014g/100ml的水溶解度的某些有机酸(例如,苯甲酸、山梨酸、癸酸、己二酸、羟基苯甲酸等和/或任何这些酸的混合物)进一步组合时,辛酸的抗细菌功效得到进一步增强(参见实施例9至12)。
在另一个形式中,当辛酸与具有在4.5至5.0之间的pKa、相对高的logP(logP>1.8)以及相对高的水溶解度(溶解度>0.5g/100ml)的有机酸进一步组合时,这样的有机酸的实例为苯丙素(phenylpropanoid)(例如,苯基丙酸(phenylproponoic acid)),抗细菌作用甚至更强,(参见实施例13)。
在另一个形式中,辛酸与某些非离子分子(例如,辛二醇、苯氧基乙醇、脱水山梨糖醇辛酸酯和混合物)组合,辛酸的活性甚至被进一步增强(参见实施例15和16)。
本发明进一步提供了一种用于通过提供组合物的描述中规定的量的成分,组合这些,和将所得混合物包装在容器中,制备本发明的组合物的方法。
本发明进一步涉及0.5至30%的辛酸在包含5至25重量%的阴离子表面活性剂,0至5重量%,优选0.5至4重量%的非离子表面活性剂和任选的两性表面活性剂的组合物中提供对抗革兰氏阳性菌和革兰氏阴性菌两者的抗细菌活性的用途,其中组合物的pH为4.5至5.5。
具体实施方式
除非是在实施例中或在另外明确指出的情况下,否则在本说明书中指示材料的量或反应条件、材料的物理特性和/或用途的所有数值都将理解为由词语“约”修饰。
如通篇使用的,范围被用作描述该范围内的各个和每个值的简略表达方式。范围内的任何值都可以被选择作为该范围的端点。和/或的使用表明可以从列表单独选择任一者或可以从列表选择任意组合。
为了避免疑问,词语“包含”旨在表示“包括”,但不一定是“由...组成”或“由...构成”。换句话说,所列步骤或选项不需要是穷举性的。
除非另有说明,否则所用成分的一个或多个量的所有百分比都应当理解为是基于组合物的总重量中的物质的有效重量的重量百分比,其总计为100%。
本发明涉及包含温和pH的合成洗涤剂基液体(其中阴离子表面活性剂占表面活性剂体系的50%或更多)。已经预料不到地发现,辛酸的使用增强了AB活性,甚至在不存在其它抗细菌剂的情况下。
具体地,所述组合物包含:
1)5至25重量%,优选8至20重量%的阴离子表面活性剂(其占表面活性剂体系的50%或更多);在一个方面,例如,所述组合物可用于细菌清除应用,如洗手液或发泡剂。
低表面活性剂制剂特别好地起作用,其中优选的表面活性剂水平为5至8%,优选6.0至7.5重量%;由于更少分配到胶束中,辛酸的可用性在低表面活性剂下最佳,
2)任选的非离子表面活性剂(例如,0至5%,优选0.5至4重量%),特别是烷基酰胺基烷醇胺;
3)任选的两性和/或两性离子表面活性剂(酰胺基甜菜碱优选地被最小化);
4)0.5至3%,特别是1.0至3%,特别是1.1或1.2或1.3至3重量%的辛酸;和
5)任选的抗细菌活性物;
其中pH为4.5至5.5,优选4.5至5.1,更优选4.5至5.0或4.5至4.9。
阴离子表面活性剂可以是例如脂肪族磺酸盐,如伯烷烃(例如,C8-C22)磺酸盐,伯烷烃(例如,C8-C22)二磺酸盐、C8-C22烯烃磺酸盐、C8-C22羟基烷烃磺酸盐或烷基甘油基醚磺酸盐(AGS);或芳香族磺酸盐,如烷基苯磺酸盐。
阴离子表面活性剂也可以为烷基硫酸盐(例如,C12-C18烷基硫酸盐)或烷基醚硫酸盐(包括烷基甘油基醚硫酸盐)。其中,烷基醚硫酸盐是具有下式的那些:
RO(CH2CH2O)nSO3M
其中R为具有8至18个碳、优选12至18个碳的烷基或烯基,n具有大于1.0,优选地在2至3之间的平均值;和M为增溶性阳离子,如钠、钾、铵或取代的铵。铵和月桂基醚硫酸钠是优选的。
特别优选的为碱金属月桂基醚硫酸盐(如,月桂基醚硫酸钠)。
阴离子表面活性剂也可以为烷基磺基琥珀酸盐(包括单和二烷基磺基琥珀酸盐,例如C6-C22磺基琥珀酸盐);烷基和酰基牛磺酸盐,烷基和酰基肌氨酸盐、磺基乙酸盐、C8-C22烷基磷酸盐和磷酸盐、烷基磷酸酯和烷氧基烷基磷酸酯、酰基乳酸盐、C8-C22单烷基琥珀酸盐和马来酸盐、磺基乙酸盐和酰基羟乙基磺酸盐。
肌氨酸盐通常由式RCON(CH3)CH2CO2M表示,其中R范围为C8至C20烷基,且M为增溶性阳离子。
牛磺酸盐通常由下式确定:
R2CONR3CH2CH2SO3M
其中R2范围为C8-C20烷基,R3范围为C2-C4烷基,且M为增溶性阳离子。
另一类阴离子表面活性剂为羧酸盐,如下:
R-(CH2CH2O)nCO2M
其中R为C8至C20烷基;n为0至20;和M为如上定义的。
可以使用的另一种羧酸盐为酰胺基烷基多肽羧酸盐,如例如Seppic的Monteine
可以使用的另一种表面活性剂为C8-C18酰基羟乙基磺酸酯。这些酯是通过碱金属羟乙基磺酸盐与具有6至18个碳原子和小于20的碘值的混合脂肪族脂肪酸之间的反应制备。至少75%的混合脂肪酸具有12至18个碳原子,且至多25%具有6至10个碳原子。
阴离子表面活性剂可以优选地为基于氨基酸的阴离子表面活性剂,如谷氨酸盐或甘氨酸盐。
可以使用的非离子表面活性剂包括具有疏水性基团和反应性氢原子的化合物,例如脂族醇、酸、酰胺或烷基酚,与环氧烷,特别是环氧乙烷单独或与环氧丙烷一起的反应产物。具体的非离子洗涤剂化合物为烷基(C6-C22)苯酚-环氧乙烷缩聚物、脂肪族(C8-C18)直链或支链伯或仲醇与环氧乙烷的缩合产物,和通过环氧乙烷与环氧丙烷和乙二胺的反应产物缩合而制备的产物。其它所谓的非离子洗涤剂化合物包括长链叔胺氧化物、长链叔膦氧化物和二烷基亚砜。
非离子表面活性剂也可以为糖酰胺,如多糖酰胺。
一种特别优选的非离子表面活性剂为烷基酰胺基烷醇胺(例如,椰油单乙醇酰胺或CMEA)。优选地,CMEA以约0.5至2重量%使用。
两性离子表面活性剂(任选的)示例为可以广泛地描述为脂肪族季铵、鏻和锍化合物的衍生物的那些,其中脂肪族基团可以为直链或支链,并且脂肪族取代基中的一个含有约8至18个碳原子且一个含有阴离子基团,例如羧基、磺酸根、硫酸根、磷酸根或膦酸根。这些化合物的通式为:
其中R2含有具有约8至约18个碳原子、0至约10个环氧乙烷部分和0至约1个甘油基部分的烷基、烯基或羟烷基基团。Y选自氮、磷和硫原子;R3为含有约1至约3个碳原子的烷基或单羟基烷基基团;当Y为硫原子时,X为1,且当Y为氮或磷原子时X为2;R4为具有约1至约4个碳原子的亚烷基或羟基亚烷基,Z为选自羧酸根、磺酸根、硫酸根、膦酸根和磷酸根的基团。
本发明中可以使用的两性洗涤剂(任选的)包含至少一个酸基团。这可以为羧酸或磺酸基团。它们包含季氮,因此为季酰胺酸。它们通常应当包含具有7至18个碳原子的烷基或烯基。它们通常将符合整体结构式:
其中R1为具有7至18个碳原子的烷基或烯基;
R2和R3各自独立地为具有1至3个碳原子的烷基、羟烷基或羧基烷基;
N为2至4;
M为0至1;
X为具有1至3个碳原子的亚烷基,任选地被羟基取代,和
Y为-CO2-或-SO3-
在上述通式内的两性洗涤剂包括下式的简单甜菜碱:
和下式的酰胺基甜菜碱:
其中m为2或3。
优选地,酰胺基甜菜碱被最小化或完全不存在。
如指出的,组合物应当包含0.1至5%,优选0.5至3%的辛酸(辛酸)。
组合物的pH应当为4.5至5.5,优选4.5至5.1,更优选4.5至5.0或4.5至4.9。pH水平为4.5至4.9是特别优选的。
在一个方面,当辛酸进一步与具有4.0至5.0之间的pKa、大于0的logP和大于0.014g/100ml的水溶解度的某些有机酸(例如,苯甲酸、山梨酸、癸酸、己二酸、羟基苯甲酸等和/或任何这些的混合物)组合时,辛酸的抗细菌功效得到增强。
在另一个方面,当辛酸进一步与具有4.0至5.0之间的pKa、相对高的logP(logP>1.8)以及相对高的水溶解度(溶解度>0.5g/100ml)的有机酸如苯丙素(例如,苯基丙酸)组合时,抗细菌作用甚至更强(参见实施例13)。
在另一个方面,辛酸与某些非离子分子(例如,辛二醇、苯氧基乙醇、脱水山梨糖醇辛酸酯及混合物)组合,辛酸的活性甚至进一步增强(参见实施例15和16)。
抗细菌活性物也可以进一步任选地加入到所述组合物中。这些可以包括百里酚、萜品醇、银、苯氧基乙醇及其混合物。如所述的,C8是高度有效的,甚至在不存在这样的抗细菌剂的情况下。
本发明进一步提供了一种用于通过提供组合物的描述中规定的量的成分,组合这些,和将所得混合物包装在容器中,制备本发明的组合物的方法。本发明进一步涉及0.5至30%的辛酸在包含5至25重量%的阴离子表面活性剂,0至5重量%、优选0.5至4重量%的非离子表面活性剂和任选的两性表面活性剂的组合物中提供对抗革兰氏阳性菌和革兰氏阴性菌两者的抗细菌活性的用途,其中组合物的pH为4.5至5.5。
实施例
提供以下非限制性实例以进一步举例说明本发明;本发明不以任何方式限制于此。使用以下方案评价杀生物活性。
体外时间-杀灭方案
皂溶液制备
溶液制备部分地取决于液体皂制剂的特定形式。例如,在使用时不稀释的制剂,例如自发泡制剂,是按原样使用。含有30重量%或更少的洗涤表面活性剂且旨在在使用时稀释的制剂与水混合以形成含有62.5重量%的初始制剂的皂溶液。含有超过30重量%的洗涤表面活性剂且旨在在使用时稀释的制剂与水混合以形成含有16重量%的初始制剂的皂溶液。
细菌
在该研究中使用大肠杆菌ATCC 10536和金黄色葡萄球菌ATCC 6538以分别代表革兰氏阴性菌和革兰氏阳性菌。将细菌储存在-80℃。在每次实验之前,将新鲜分离物在胰蛋白酶大豆琼脂板上在37℃下培养2次24小时。
体外时间-杀灭试验
时间-杀灭试验是根据题为“Chemical Disinfectants and Antiseptics -Quantitative Suspension Test for the Evaluation of Basic BactericidalActivity of Chemical Disinfectants and Antiseptics-Test Method andRequirements(Phase 1)”的欧洲标准EN 1040:2005进行,其通过引用并入本文。在该程序之后,在25℃下,用皂溶液(如上所述制备的)处理1.5×108至5×108个菌落形成单位每ml(cfu/ml)的生长阶段细菌培养物。在形成测试样品时,将如上所述制备的8重量份的皂溶液与1重量份的培养物和1重量份的水组合。在暴露10、20和30秒之后,中和样品以中止皂溶液的抗细菌活性。然后将测试溶液连续稀释,铺板在固体培养基上,培养24小时,并对存活细胞进行枚举。杀细菌活性定义为相对于0秒时的细菌浓度以cfu/ml计的Log降低。没有暴露于任何皂溶液的培养物作为未处理对照。
使用下式计算Log10降低:
Log10降低=Log10(对照数量)-Log10(测试样品存活者)
对照实施例和本发明的实施例1至4见于下表1。
表1
表2
杀生物活性
如表2的数据所证实的,在指定接触时间,与对照相比,加入1.0%、1.5%和2.0%的辛酸(实施例1、2、3、4)提高了抗微生物功效。加入椰油酰胺丙基甜菜碱相对于对照仍然有效,但是相对于具有相同量的辛酸的实施例抑制了提高作用;如所看到的,实施例4比实施例2具有相对更少的抗微生物功效。
实施例2、3和4相对于实施例1还显示,大于1.0%的辛酸(例如,1.1或1.2或1.5至3%)的使用是特别有效的。
表3
表4
杀生物活性
对抗大肠杆菌ATCC 10536的Log10降低
如表4的数据证实的,在指定接触时间,pH 4.9的实施例5具有比pH 5.4的实施例6更大的对抗大肠杆菌ATCC 10536的杀细菌功效;这证实了在4.5至5.1,或特别是4.5至5.0,特别是4.5至4.9范围的pH对于含有辛酸的非皂制剂的抗微生物功效的特别强的作用。
实施例7和8涉及含有辛酸的具有高发泡性质的清洁剂制剂。在这些具体实施例中,在约5%至8%的相对较低的表面活性剂水平下,辛酸由于可用性增加而特别好地起作用。
表5
成分(重量%) | 实施例7 | 实施例8 |
水 | 平衡至100 | 平衡至100 |
乙二胺四乙酸四钠盐 | 0.1 | 0.1 |
SLES | 7 | 5.5 |
CMEA | 1 | 0.5 |
辛酸C8 | 1 | 0.75 |
苯甲酸 | 1.5 | 0.75 |
甲基氯异噻唑啉酮 | 0.06 | 0.06 |
二苯甲酮-4 | 0.1 | 0.1 |
丙二醇 | 6 | / |
PEG 200 | / | 6 |
NaOH | 为了调节pH | 为了调节pH |
pH | 4.53 | 4.9 |
表6
杀生物活性
对抗大肠杆菌ATCC 10536的Log10降低
如表6的数据证实的,在指定接触时间,实施例7和8具有比对照(无辛酸)更大的对抗大肠杆菌ATCC 10536和金黄色葡萄球菌ATCC 6538两者的杀细菌功效。
表7
各种有机酸的物理性质
有机酸 | pKa | LogP | 水溶解度 |
酒石酸 | 3.22,4.85 | -1.43 | 133g/100ml |
辛酸 | 4.89 | 3.05 | 0.068g/100ml |
苯甲酸 | 4.19 | 1.87 | 0.344g/100ml(25℃) |
己二酸 | 4.43,5.41 | 0.08 | 2.4g/100ml(25℃) |
羟基苯甲酸 | 4.54 | 1.58 | 0.5/100ml |
山梨酸 | 4.76 | 1.47 | 0.16/100ml(20℃) |
癸酸 | 4.9 | 4.09 | 0.015g/100ml(20℃) |
3-苯基丙酸 | 4.65 | 1.84 | 0.59g/100ml |
表8
表9
杀生物活性
对抗大肠杆菌ATCC 10536的Log10降低
如表9数据证实的,在指定接触时间,实施例9至13(辛酸与满足pKa在4.0至5.0之间,logP>0且水溶解度>0.014g/100ml的要求的有机酸的组合)具有比实施例1(仅含有辛酸)更大的对抗大肠杆菌ATCC 10536的杀细菌功效。比较例C是具有过低的logP的有机酸的反面实施例。
表10
表11
杀生物活性
如表11数据证实的,在指定接触时间,实施例15和16(辛酸与非离子表面活性剂组合,如脱水山梨糖醇辛酸酯或辛二醇)具有比其对应的比较例D和E(单独的辛酸,不含非离子表面活性剂)更大的杀细菌功效。
Claims (14)
1.一种液体组合物,其包含:
a)5至25%的阴离子表面活性剂;
b)0至5%的非离子表面活性剂
c)任选的两性表面活性剂,
其中阴离子表面活性剂是表面活性剂的50%或更多;
d)0.5至3%的辛酸;
其中pH为4.5至4.9,
其中还存在具有4.5至5.0的pKa、大于1.8的logP和大于0.5g/100ml的水溶解度的有机酸,其中所述有机酸是苯基丙酸。
2.根据权利要求1所述的组合物,其中阴离子表面活性剂为烷基硫酸盐、基于氨基酸的表面活性剂、或其混合物。
3.根据权利要求1所述的组合物,其中非离子表面活性剂是任选的0.5至4%的含量。
4.根据权利要求1至3中任一项所述的任选的组合物,其中如果存在,非离子表面活性剂为椰油单烷醇酰胺。
5.根据权利要求1至3中任一项所述的组合物,其还包含抗细菌剂。
6.根据权利要求5所述的组合物,其中这样的抗细菌剂选自百里酚、萜品醇、银、苯氧基乙醇及其混合物。
7.根据权利要求1至3中任一项所述的组合物,其中所述有机酸为3-苯基丙酸。
8.根据权利要求1至3中任一项所述的组合物,其中还存在与所述非离子表面活性剂不同的非离子分子。
9.根据权利要求8所述的组合物,其中所述非离子分子选自辛二醇、苯氧基乙醇、脱水山梨糖醇辛酸酯及其混合物。
10.根据权利要求1至3中任一项所述的组合物,其中总表面活性剂以组合物的5至8%存在。
11.一种制备权利要求1至10中任一项所述的组合物的方法,其包括:
a)提供5至25重量%的阴离子表面活性剂,0至5重量%的非离子表面活性剂,任选的两性表面活性剂和0.5至3%的辛酸;
b)组合(a)的所述组分以形成pH为4.5至4.9的液体混合物;
c)将所得混合物包装在容器中。
12.根据权利要求11所述的方法,其中非离子表面活性剂为0.5至4重量%。
13.0.5至3.0重量%的辛酸在包含5至25%的阴离子表面活性剂,0至5重量%的非离子表面活性剂和任选的两性表面活性剂的组合物中提供对抗革兰氏阳性菌和革兰氏阴性菌两者的抗细菌活性的非治疗用途,其中所述组合物的pH为4.5至4.9;其中还存在具有4.5至5.0的pKa、大于1.8的logP和大于0.5g/100ml的水溶解度的有机酸,其中所述有机酸是苯基丙酸。
14.根据权利要求13所述的非治疗用途,其中非离子表面活性剂为0.5至4重量%。
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0044582A2 (en) * | 1980-06-30 | 1982-01-27 | THE PROCTER & GAMBLE COMPANY | Liquid skin cleanser composition |
US5132037A (en) * | 1989-05-05 | 1992-07-21 | Lever Brothers Company, Division Of Conopco, Inc. | Aqueous based personal washing cleanser |
US5681802A (en) * | 1994-06-01 | 1997-10-28 | Lever Brothers Company, Division Of Conopco, Inc. | Mild antimicrobial liquid cleansing formulations comprising buffering compound or compounds as potentiator of antimicrobial effectiveness |
CN102267895A (zh) * | 2011-08-04 | 2011-12-07 | 云南烟草科学研究院 | 一种苯丙素类化合物及其制备方法和用途 |
CN106038348A (zh) * | 2016-07-04 | 2016-10-26 | 广州环亚化妆品科技有限公司 | 一种具有防腐功效的组合物及其在化妆品中的应用 |
CN106232091A (zh) * | 2014-02-14 | 2016-12-14 | 凯敏工业公司 | 牛至油及辛酸混合物的抗菌作用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5783597A (en) * | 1980-06-30 | 1982-05-25 | Procter & Gamble | Foam promotor-containing liquid surfactant skin cleaner |
EP0802786B1 (en) | 1995-01-09 | 2000-12-13 | The Procter & Gamble Company | Three in one ultra mild lathering antibacterial liquid personal cleansing composition |
US6482423B1 (en) * | 1999-04-13 | 2002-11-19 | The Procter & Gamble Company | Antimicrobial wipes which provide improved residual benefit versus gram positive bacteria |
JP2002145719A (ja) * | 2000-11-07 | 2002-05-22 | Toyo Beauty Kk | 化粧料 |
US8809392B2 (en) * | 2008-03-28 | 2014-08-19 | Ecolab Usa Inc. | Sulfoperoxycarboxylic acids, their preparation and methods of use as bleaching and antimicrobial agents |
US8722609B2 (en) * | 2008-04-04 | 2014-05-13 | Ecolab Inc | Limescale and soap scum removing composition containing methane sulfonic acid |
DE102009022444A1 (de) | 2009-05-23 | 2010-01-07 | Clariant International Limited | Zusammensetzung enthaltend Sorbitanmonocaprylat und antimikrobielle Wirkstoffe |
CN106795636B (zh) * | 2014-06-17 | 2020-07-24 | 凯密特尔有限责任公司 | 用于温和地除去油墨和标识物的清洁剂 |
-
2018
- 2018-09-26 CN CN201880066013.5A patent/CN111246835B/zh active Active
- 2018-09-26 EP EP18772831.6A patent/EP3700500B1/en active Active
- 2018-09-26 JP JP2020514985A patent/JP7277441B2/ja active Active
- 2018-09-26 MX MX2020004141A patent/MX2020004141A/es unknown
- 2018-09-26 US US16/756,627 patent/US11607377B2/en active Active
- 2018-09-26 WO PCT/EP2018/076145 patent/WO2019081152A1/en active Search and Examination
- 2018-09-26 EA EA202090436A patent/EA202090436A1/ru unknown
- 2018-09-26 CA CA3075701A patent/CA3075701A1/en active Pending
-
2020
- 2020-03-04 ZA ZA2020/01395A patent/ZA202001395B/en unknown
-
2023
- 2023-02-09 US US18/107,591 patent/US11975085B2/en active Active
- 2023-03-14 JP JP2023039898A patent/JP2023075279A/ja active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0044582A2 (en) * | 1980-06-30 | 1982-01-27 | THE PROCTER & GAMBLE COMPANY | Liquid skin cleanser composition |
US5132037A (en) * | 1989-05-05 | 1992-07-21 | Lever Brothers Company, Division Of Conopco, Inc. | Aqueous based personal washing cleanser |
US5681802A (en) * | 1994-06-01 | 1997-10-28 | Lever Brothers Company, Division Of Conopco, Inc. | Mild antimicrobial liquid cleansing formulations comprising buffering compound or compounds as potentiator of antimicrobial effectiveness |
CN102267895A (zh) * | 2011-08-04 | 2011-12-07 | 云南烟草科学研究院 | 一种苯丙素类化合物及其制备方法和用途 |
CN106232091A (zh) * | 2014-02-14 | 2016-12-14 | 凯敏工业公司 | 牛至油及辛酸混合物的抗菌作用 |
CN106038348A (zh) * | 2016-07-04 | 2016-10-26 | 广州环亚化妆品科技有限公司 | 一种具有防腐功效的组合物及其在化妆品中的应用 |
Non-Patent Citations (2)
Title |
---|
Antibacterial activity of caprylic acid for potential application as an active antiseptic ingredient in consumer antiseptics;S.A.Kim1M.S.Rhee;《 International Journal of Antimicrobial Agents》;20160929;第765-767页. * |
山梨坦辛酸酯在个人护理产品中的防腐协同增效作用研究;庄孟芙等;《中国洗涤用品工业》;20170615;第39-43页. * |
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BR112020004565A2 (pt) | 2020-09-08 |
US11975085B2 (en) | 2024-05-07 |
WO2019081152A1 (en) | 2019-05-02 |
CA3075701A1 (en) | 2019-05-02 |
EA202090436A1 (ru) | 2020-10-09 |
CN111246835A (zh) | 2020-06-05 |
EP3700500B1 (en) | 2021-10-27 |
JP2021508671A (ja) | 2021-03-11 |
MX2020004141A (es) | 2021-11-18 |
EP3700500A1 (en) | 2020-09-02 |
JP7277441B2 (ja) | 2023-05-19 |
US20200352836A1 (en) | 2020-11-12 |
JP2023075279A (ja) | 2023-05-30 |
US11607377B2 (en) | 2023-03-21 |
US20230190602A1 (en) | 2023-06-22 |
ZA202001395B (en) | 2021-08-25 |
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