CN111218339A - Ultrahigh pressure extraction method of atractylis lancea volatile oil - Google Patents
Ultrahigh pressure extraction method of atractylis lancea volatile oil Download PDFInfo
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- CN111218339A CN111218339A CN201811412248.3A CN201811412248A CN111218339A CN 111218339 A CN111218339 A CN 111218339A CN 201811412248 A CN201811412248 A CN 201811412248A CN 111218339 A CN111218339 A CN 111218339A
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/02—Recovery or refining of essential oils from raw materials
- C11B9/025—Recovery by solvent extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/02—Recovery or refining of essential oils from raw materials
- C11B9/022—Refining
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/02—Recovery or refining of essential oils from raw materials
- C11B9/027—Recovery of volatiles by distillation or stripping
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
Abstract
The application discloses an ultrahigh pressure extraction method of atractylis lancea volatile oil, which comprises the following steps: step 1, taking a rhizoma atractylodis lanceae raw material, crushing the rhizoma atractylodis lanceae raw material into fine powder, sieving the fine powder with a 18-mesh sieve, and drying the fine powder for 4 hours at the temperature of 60 ℃; step 2, extracting the atractylis lancea with a solvent under the condition of ultrahigh pressure; and 3, separating the solvent and the volatile oil to obtain the volatile oil. The method can efficiently obtain crude volatile oil from rhizoma Atractylodis by selecting and controlling extraction solvent, extraction time and extraction pressure, and has the advantages of short extraction time, low energy consumption, low temperature, no thermal damage to active ingredients, etc.
Description
The technical field is as follows:
the invention belongs to the field of natural product extraction, and relates to an ultrahigh pressure extraction method of atractylis lancea volatile oil.
Background art:
atractylodes lancea (Atractylodes lancea DC), also called as Atractylodes lancea, is a plant of Compositae, fond of cool and dry climate, and has gray-brown root surface, wrinkles, transverse striations and fibrous root marks, firm texture, yellowish white or grey-white cross section, most of reddish brown oil chambers, special aroma, slightly sweet, pungent and bitter taste.
The extraction of plant volatile oils often uses steam distillation (HD) methods. The steam distillation method comprises soaking coarse powder or fragments of medicinal materials containing volatile components in water, heating with direct fire for distillation or introducing steam for distillation, or decocting medicinal materials in a Chinese medicinal extraction tank while distilling, wherein volatile components in the medicinal materials are carried out with steam distillation, condensing, collecting distillate, generally distilling twice to increase extraction rate, and collecting distillate; the distillation times in steam distillation should not be too high to avoid oxidation or decomposition of some components in the volatile oil. Steam distillation requires continuous heating of the feedstock and in many cases continuous distillation for several hours, and is therefore not suitable for the extraction of chemically unstable components. The steam distillation method has long extraction process time, high temperature, open system, easy damage and volatilization loss of heat instability and easily-oxidized components, and damage effect on extracted components. Therefore, how to obtain more volatile oil components becomes a problem.
The ultrahigh pressure is called as ultrahigh cold isostatic pressing, and is called as cold isostatic pressing for short, and the ultrahigh pressure is the hydrostatic pressure with the pressure of 100-1000 MPa. The ultrahigh pressure biological treatment technology has wide application field, and provides a new platform for scientific research, product development and process innovation of biological, medical and food engineering. Based on the new technology, the traditional Chinese medicine extraction field has literature reports: compared with the traditional extraction technology, the ultrahigh pressure extraction technology can greatly shorten the extraction time, reduce the energy consumption, reduce the dissolution of impurity components, improve the yield of effective components and the like, so the research of the ultrahigh pressure extraction technology is proposed to improve the extraction efficiency.
The invention content is as follows:
the invention aims to provide a method for efficiently extracting atractylis lancea crude volatile oil, provides an efficient and convenient technical means for obtaining atractylis lancea volatile oil, and realizes the effects of energy conservation and efficient utilization of resources.
The method comprises the following steps:
step 1, taking a rhizoma atractylodis lanceae raw material, crushing the rhizoma atractylodis lanceae raw material into fine powder, sieving the fine powder with a 18-mesh sieve, and drying the fine powder for 4 hours at 60 ℃;
step 2, extracting the atractylis lancea with a solvent under the condition of ultrahigh pressure;
step 3, separating the solvent and the volatile oil to obtain the volatile oil;
wherein, the solvent in step 2 is selected from any solvent capable of dissolving the volatile oil of the traditional Chinese medicine, including but not limited to ethanol, methanol, diethyl ether, carbon disulfide, chloroform, ethyl acetate, n-butanol, petroleum ether, n-hexane, and their mixture and their aqueous solution; the dosage of the solvent is 1-60 times of the volume of the weight of the traditional Chinese medicinal materials; the ultrahigh pressure condition is that the pressure range is required to be controlled to be 100-1000Mpa during extraction; the duration of the ultrahigh pressure extraction is 1-30 minutes;
wherein, the solvent and the volatile oil are separated in the step 3 by adopting a normal pressure or reduced pressure distillation method.
Example (b):
example 1
Taking 20g of atractylis lancea medicinal material, adding 200ml of 95% ethanol, extracting for 10min under the condition of 400Mpa ultrahigh pressure, filtering to obtain an extracting solution, recovering ethanol from the extracting solution at 60 ℃ under reduced pressure to obtain crude atractylis lancea volatile oil, wherein the crude atractylis lancea volatile oil is 0.65g through detection, and the yield is 3.25%.
Example 2
Taking 20g of rhizoma atractylodis lanceae, adding 1200ml of 40% ethanol, extracting for 5min under the condition of 1000Mpa ultrahigh pressure, filtering to obtain an extracting solution, and recovering ethanol from the extracting solution at 40 ℃ under reduced pressure to obtain 0.72g of crude volatile oil with the yield of 3.60%.
Example 3
Taking 20g of rhizoma atractylodis lanceae, adding 60ml of absolute ethanol, extracting for 30min under the condition of 100Mpa ultrahigh pressure, filtering to obtain an extracting solution, and recovering ethanol from the extracting solution at 90 ℃ under reduced pressure to obtain 0.74g of crude volatile oil with the yield of 3.70%.
Example 4
Taking 200g of atractylis lancea medicinal material, adding 1000ml of 95% ethanol, extracting for 5min under the condition of 200Mpa ultrahigh pressure, filtering to obtain an extracting solution, and recovering ethanol from the extracting solution at 30 ℃ under reduced pressure to obtain 18.76g of crude volatile oil with the yield of 3.45%.
Example 5
Taking 200g of atractylis lancea medicinal material, adding 5000ml of 80% ethanol, extracting for 30min under the condition of 800Mpa ultrahigh pressure, filtering to obtain an extracting solution, and recovering ethanol from the extracting solution at 40 ℃ under reduced pressure to obtain 20.83g of crude volatile oil, wherein the yield is 3.95%.
Claims (4)
1. A method for efficiently extracting crude volatile oil is characterized by comprising the following steps:
step 1, taking a rhizoma atractylodis lanceae raw material, crushing the rhizoma atractylodis lanceae raw material into fine powder, sieving the fine powder with a 18-mesh sieve, and drying the fine powder for 4 hours at 60 ℃;
step 2, extracting the atractylis lancea with a solvent under the condition of ultrahigh pressure;
step 3, separating the solvent and the volatile oil to obtain the volatile oil;
wherein the solvent in step 2 is selected from any solvent capable of dissolving Chinese medicinal volatile oil, including but not limited to ethanol, methanol, diethyl ether, carbon disulfide, chloroform, ethyl acetate, n-butanol, petroleum ether, n-hexane, their mixture and their aqueous solution, wherein the solvent and volatile oil are separated in step 3 by distillation under normal pressure or reduced pressure.
2. The method according to claim 1, wherein the solvent used in step 2 is 1 to 60 times by volume of the solvent.
3. The process of claim 1, wherein the ultra-high pressure conditions in step 2 are: the pressure is 100-1000Mpa, and the extraction time is 5-30 min.
4. The method of claim 1, wherein the step 3 comprises filtering to obtain an extract, and distilling the extract at 40-90 deg.C under reduced pressure to obtain the volatile oil.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811412248.3A CN111218339A (en) | 2018-11-25 | 2018-11-25 | Ultrahigh pressure extraction method of atractylis lancea volatile oil |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811412248.3A CN111218339A (en) | 2018-11-25 | 2018-11-25 | Ultrahigh pressure extraction method of atractylis lancea volatile oil |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111218339A true CN111218339A (en) | 2020-06-02 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811412248.3A Pending CN111218339A (en) | 2018-11-25 | 2018-11-25 | Ultrahigh pressure extraction method of atractylis lancea volatile oil |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111218339A (en) |
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2018
- 2018-11-25 CN CN201811412248.3A patent/CN111218339A/en active Pending
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Application publication date: 20200602 |