CN111208137A - Thrombus elasticity measurement system based on optical fiber sensing - Google Patents
Thrombus elasticity measurement system based on optical fiber sensing Download PDFInfo
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- CN111208137A CN111208137A CN202010059884.3A CN202010059884A CN111208137A CN 111208137 A CN111208137 A CN 111208137A CN 202010059884 A CN202010059884 A CN 202010059884A CN 111208137 A CN111208137 A CN 111208137A
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- optical fiber
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N2021/0106—General arrangement of respective parts
- G01N2021/0112—Apparatus in one mechanical, optical or electronic block
Abstract
The invention discloses a thrombus elasticity measuring system based on optical fiber sensing, which comprises a detecting device and a measuring cup, wherein the detecting device comprises a suspension wire, a reflector and a probe, and also comprises an optical fiber sensor, a subtracter, a phase-locked amplifier and a collecting card, the optical fiber sensor comprises a laser, a transmitting optical fiber, a first receiving optical fiber, a second receiving optical fiber, a first detector and a second detector, wherein laser modulated by preset frequency is emitted from the output end of the transmitting optical fiber at a set divergence angle, light reflected by the surface of the reflector enters the first receiving optical fiber and the second receiving optical fiber, the first detector and the second detector convert received optical signals into electric signals and input the electric signals into the subtracter, the output signal of the subtracter is demodulated by the phase-locked amplifier at the preset frequency, and the output signal of the phase-locked amplifier is collected by a computer through the collecting card. The invention can effectively reduce the interference of external natural light and can be used for judging the rotation direction of the rotary reflector.
Description
Technical Field
The invention relates to the technical field of blood coagulation analysis, in particular to a thrombus elasticity measuring system.
Background
The measurement principle of the existing thrombus elasticity measurement system is as follows: under the condition of a set constant temperature, blood in the measuring cup is gradually coagulated under the condition of small-amplitude oscillation shearing (amplitude of 4.750 and cycle of 10 seconds), fibrin, platelets and blood cells in the blood gradually form a three-dimensional cross-linked reticular structure (blood clot), so that the measuring cup and the probe are coupled to drive the probe in the blood to oscillate back and forth, and the oscillation amplitude of the probe gradually increases along with the progress of blood coagulation.
When the fibrinolysis mechanism is started, the blood clot is shrunk or dissolved, the coupling between the probe and the measuring cup is gradually weakened until finally released, the shearing force transmitted to the probe by the movement of the measuring cup is gradually reduced until eliminated, and correspondingly, the oscillation amplitude of the probe is also gradually reduced. Thus, the amplitude of oscillation of the probe is positively correlated with the strength of the clot.
The method for detecting the torsion angle of the probe includes an electromagnetic measurement method and an optical lever method.
In an electromagnetic measurement method, the torsion angle of a probe is detected by a differential inductance type displacement sensor, and is transmitted to a data processing system, and a thrombus elastic spectrogram is finally generated through processing of an envelope algorithm. The sensor is comprised of a coil and an armature printed on a differential Printed Circuit Board (PCB) with an air gap therebetween.
Chinese patent document CN 104062207B discloses a blood viscoelastic force monitoring device, which uses an optical lever method to measure the torsion angle of a probe, wherein a mirror surface is fixedly connected to the probe, a laser emitter and an angular displacement sensor are arranged opposite to the mirror surface, and the angular displacement sensor receives laser emitted by the laser emitter and reflected by the mirror surface.
Compared with an electromagnetic measurement method, the optical lever method enables measurement accuracy and sensitivity to be improved remarkably. In the process of implementing the invention, the inventor finds that: in the blood viscoelastic monitoring device, external natural light interferes the measurement result.
Disclosure of Invention
The invention aims to provide a thrombus elasticity measuring system based on optical fiber sensing to eliminate the interference of external natural light on a measuring result.
The invention provides a thrombus elasticity measuring system based on optical fiber sensing, which comprises a detecting device and a measuring cup, wherein the detecting device comprises a suspension wire, a reflector and a probe, and also comprises an optical fiber sensor, a subtracter, a phase-locked amplifier and a collecting card, the optical fiber sensor comprises a laser, an emitting optical fiber, a first receiving optical fiber and a second receiving optical fiber which are symmetrically arranged at two sides of the emitting optical fiber, a first detector matched with the first receiving optical fiber and a second detector matched with the second receiving optical fiber, wherein laser modulated by preset frequency is emitted from the output end of the emitting optical fiber at a set divergence angle, light reflected by the surface of the reflector enters the first receiving optical fiber and the second receiving optical fiber, the first detector and the second detector convert received optical signals into electric signals and input the electric signals into the subtracter, the output signal of the subtracter is demodulated by the phase-locked amplifier at the preset frequency, the output signal of the phase-locked amplifier is acquired by a computer through an acquisition card.
Further, the above laser uses a red light source having a wavelength of 650 nm.
The invention designs a small optical fiber sensing thrombus elasticity measuring system with extremely high precision and simple structure by utilizing the optical fiber sensing principle. The transmitting optical fiber and the receiving optical fiber which is symmetrically arranged about the transmitting optical fiber are arranged to receive light, and after optical signals are converted into electric signals by respective detectors, the electric signals are input into a differentiator (namely a subtracter) for processing, so that the interference of external natural light on a measurement result can be eliminated, and meanwhile, the rotating direction of the rotating reflector can be judged.
In addition to the objects, features and advantages described above, other objects, features and advantages of the present invention are also provided. The present invention will be described in further detail below with reference to the drawings.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this application, illustrate embodiments of the invention and, together with the description, serve to explain the invention and not to limit the invention. In the drawings:
FIG. 1 is a schematic diagram of a thrombus elasticity measurement in the prior art;
FIG. 2 is a schematic structural diagram of a detection device of the optical fiber sensing-based thromboelastometry system according to the invention;
FIG. 3 is a schematic view showing the structure of a probe of a probing apparatus of the thrombus elasticity measuring system according to the present invention;
FIG. 4 is a measurement principle of a probe device of the thrombus elasticity measurement system according to the present invention when the angle of a mirror is changed;
FIG. 5 is a schematic view of the variation of light intensity with deflection angle measured by the detection device according to the present invention; and
fig. 6 is a graph comparing theoretical values with measured values of a probe device according to the present invention.
Detailed Description
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to the embodiments with reference to the attached drawings.
The invention designs a thrombus elasticity measuring system based on optical fiber sensing. The working principle of the system is as follows: under the condition of a set constant temperature, blood in the measuring cup is gradually coagulated under the condition of small-amplitude oscillation shearing (amplitude of 4.750 and cycle of 10 seconds), fibrin, platelets and blood cells in the blood gradually form a three-dimensional cross-linked reticular structure (blood clot), so that the measuring cup and the probe are coupled to drive the probe in the blood to oscillate back and forth, and the oscillation amplitude of the probe gradually increases along with the progress of blood coagulation.
When the fibrinolysis mechanism is started, the blood clot is shrunk or dissolved, the coupling between the probe and the measuring cup is gradually weakened until finally released, the shearing force transmitted to the probe by the movement of the measuring cup is gradually reduced until eliminated, and correspondingly, the oscillation amplitude of the probe is also gradually reduced.
Thus, the amplitude of oscillation of the probe is positively correlated with the strength of the clot. The torsion angle of the probe is detected by an angular displacement measuring system based on optical fiber sensing, and is transmitted to a data processing system, and a thrombus elastic spectrogram is finally generated after processing.
As shown in fig. 2 and 3, the probing device comprises a suspension wire, a reflector and a probe, wherein the suspension wire resists the probe from twisting and provides restoring force for returning to the central position, the reflector is embedded at the uppermost end of the probe, and the cup head of the transferring and measuring cup at the end part of the probe is immersed in blood to be tested and is used for monitoring the change of the shear modulus of thrombus.
If the probe rotates to drive the thrombus to rotate when the measuring cup rotates, the probe rotates counterclockwise by an angle relative to the initial position due to the shearing force
Thereby driving the reflector to also deflect an angle
Since the angle at which the shearing force deflects the probe is reflected by the deflected light rays from the mirror, the probe is deflected at a high angle by the shearing force
In the detection device, in order to reduce background noise and improve the signal-to-noise ratio, a sinusoidal signal with the frequency less than 5k is used for modulating a laser light source, and the modulated light is coupled to a transmitting optical fiber. The modulated light output from the emitting fiber will then be transmitted to the rotating mirror at a certain divergence angle. At the surface of the rotating mirror, the reflected light beam enters the receiving optical fiber 1 and the receiving optical fiber 2.
The light beams output by the receiving optical fiber 1 and the receiving optical fiber 2 respectively enter the detector 1 and the detector 2, the detector converts the received optical signals into electric signals and then enters the subtracter, and due to the fact that the modulation signal with a certain specific frequency is adopted, interference of external natural light can be effectively reduced, and meanwhile the modulation signal can be used for judging the rotating direction of the rotating reflector.
The output signal of the subtracter is demodulated at a specific frequency by a phase-locked amplifier, and the output signal of the phase-locked amplifier is acquired by a computer through an acquisition card.
Aiming at the design system, a red light source with the wavelength of 650nm is used, experimental study is carried out on the change relation between the deflection of the reflector and the light intensity, and the measurement result is shown in figure 5.
As can be seen from fig. 5: the measured signal is minimum (zero when the deflection mirror deflects 9 degrees anticlockwise, namely-9 degrees, -1750mV., when the deflection mirror deflects 9 degrees clockwise, namely-9 degrees, -1730 mV., experiments show that the design system can accurately reflect the change of the angle of the deflection mirror through light intensity, and the electromagnetic measurement system of the thrombus elasticity measurement system can be perfectly replaced by the design system.
In the deflection process of the reflector, the light emitting angle of the emitting optical fiber is unchanged, and because the incident angle of the incident light of the reflecting mirror surface is changed when the reflector rotates, the light energy entering the receiving optical fiber is changed, which is the mechanism that the detector receives light energy with different sizes after the reflector deflects. It is to be emphasized that: the light emitted by the light source is a beam of light rather than a line of light.
Furthermore, experiments also measure and simulate the light beams transmitted by the two optical fibers and the light intensity change caused by the deflection of the reflector when the reflector in fig. 4 deflects. The measurement and simulation results are shown in fig. 6.
In fig. 6, the positive and negative values of the light intensity are the results obtained by taking the difference between clockwise and counterclockwise light intensity as the reference, and taking clockwise direction as positive and counterclockwise direction as negative, and it can be seen from fig. 6 that the differential design system can sensitively reflect the change of the deflection angle with the light intensity.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (2)
1. A thrombus elasticity measuring system based on optical fiber sensing comprises a detecting device and a measuring cup, and is characterized in that the detecting device comprises a suspension wire, a reflector and a probe, and also comprises an optical fiber sensor, a subtracter, a phase-locked amplifier and a collecting card, wherein the optical fiber sensor comprises a laser, an emitting optical fiber, a first receiving optical fiber and a second receiving optical fiber which are symmetrically arranged at two sides of the emitting optical fiber, a first detector matched with the first receiving optical fiber and a second detector matched with the second receiving optical fiber, wherein laser modulated by preset frequency is emitted from the output end of the emitting optical fiber at a set divergence angle, light reflected by the surface of the reflector enters the first receiving optical fiber and the second receiving optical fiber, the first detector and the second detector convert received optical signals into electric signals and input the electric signals into the subtracter, the output signal of the subtracter is demodulated by the phase-locked amplifier at the preset frequency, the output signal of the phase-locked amplifier is acquired by a computer through an acquisition card.
2. The optical fiber sensing-based thromboelastometry system of claim 1, wherein the laser uses a red light source with a wavelength of 650 nm.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010059884.3A CN111208137A (en) | 2020-01-19 | 2020-01-19 | Thrombus elasticity measurement system based on optical fiber sensing |
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| CN202010059884.3A CN111208137A (en) | 2020-01-19 | 2020-01-19 | Thrombus elasticity measurement system based on optical fiber sensing |
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Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5654539A (en) * | 1995-08-17 | 1997-08-05 | Vasamedics L.L.C. | Laser doppler optical sensor for use on a monitoring probe |
| US20020080362A1 (en) * | 2000-12-22 | 2002-06-27 | Feredoon Behroozi | Apparatus and method for measurement of fluid viscosity |
| CN101799282A (en) * | 2010-04-28 | 2010-08-11 | 东北大学 | Reflection-type angular displacement transducer and measuring method based on optical fiber array |
| CN102589483A (en) * | 2012-01-10 | 2012-07-18 | 哈尔滨工程大学 | Method and device for sensing angular displacement of reflective differential intensity modulating optical fiber |
| CN104062207A (en) * | 2014-07-15 | 2014-09-24 | 中国科学院苏州生物医学工程技术研究所 | Monitoring device for viscoelastic strength of blood |
| CN105842432A (en) * | 2016-04-29 | 2016-08-10 | 苏州品诺维新医疗科技有限公司 | Thrombus elastometer and method for detecting rotation angle of rotating shaft |
| US20160377638A1 (en) * | 2015-06-29 | 2016-12-29 | C A Casyso Ag | Blood Testing System and Method |
| CN107091619A (en) * | 2017-06-22 | 2017-08-25 | 凌中鑫 | The angular deflection detecting system of thrombelastogram instrument |
| WO2017186184A1 (en) * | 2016-04-29 | 2017-11-02 | 诺泰科生物科技（苏州）有限公司 | Apparatus for measuring blood coagulation data |
-
2020
- 2020-01-19 CN CN202010059884.3A patent/CN111208137A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5654539A (en) * | 1995-08-17 | 1997-08-05 | Vasamedics L.L.C. | Laser doppler optical sensor for use on a monitoring probe |
| US20020080362A1 (en) * | 2000-12-22 | 2002-06-27 | Feredoon Behroozi | Apparatus and method for measurement of fluid viscosity |
| CN101799282A (en) * | 2010-04-28 | 2010-08-11 | 东北大学 | Reflection-type angular displacement transducer and measuring method based on optical fiber array |
| CN102589483A (en) * | 2012-01-10 | 2012-07-18 | 哈尔滨工程大学 | Method and device for sensing angular displacement of reflective differential intensity modulating optical fiber |
| CN104062207A (en) * | 2014-07-15 | 2014-09-24 | 中国科学院苏州生物医学工程技术研究所 | Monitoring device for viscoelastic strength of blood |
| US20160377638A1 (en) * | 2015-06-29 | 2016-12-29 | C A Casyso Ag | Blood Testing System and Method |
| CN105842432A (en) * | 2016-04-29 | 2016-08-10 | 苏州品诺维新医疗科技有限公司 | Thrombus elastometer and method for detecting rotation angle of rotating shaft |
| WO2017186184A1 (en) * | 2016-04-29 | 2017-11-02 | 诺泰科生物科技（苏州）有限公司 | Apparatus for measuring blood coagulation data |
| CN107091619A (en) * | 2017-06-22 | 2017-08-25 | 凌中鑫 | The angular deflection detecting system of thrombelastogram instrument |
Non-Patent Citations (1)
| Title |
|---|
| 中国科学技术大学普通物理实验室: "《大学物理实验 第三册》", 31 March 1997, 中国科学技术大学出版社 * |
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