CN111196796A - A method for extracting quercetin from herba Taxilli - Google Patents
A method for extracting quercetin from herba Taxilli Download PDFInfo
- Publication number
- CN111196796A CN111196796A CN201811374150.3A CN201811374150A CN111196796A CN 111196796 A CN111196796 A CN 111196796A CN 201811374150 A CN201811374150 A CN 201811374150A CN 111196796 A CN111196796 A CN 111196796A
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- CN
- China
- Prior art keywords
- quercetin
- collecting
- filter residue
- coarse powder
- degreasing
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/40—Separation, e.g. from natural material; Purification
Abstract
The invention discloses a preparation method for extracting quercetin from loranthus parasiticus, which is characterized by comprising the following steps: 1) pulverizing dried herba Taxilli raw material, sieving with 30-60 mesh sieve, and collecting coarse powder; 2) degreasing: weighing a certain amount of coarse powder, and adding the coarse powder into the mixture according to a material-liquid ratio of 1: 3-5, soaking in petroleum ether solution, and placing in a constant temperature water bath at 70-90 deg.C for degreasing and decolorizing for 60-90 min; 3) recovering petroleum ether from the treated degreasing solution, collecting the filter residue of the parasitic loranthus, and drying the filter residue in a drying oven at 60 ℃; 4) putting the weighed filter residue with a certain mass into 70-90% of absolute ethyl alcohol solution according to the material-liquid ratio of 1:3-10, placing the device in microwave for treatment, and performing suction filtration treatment after 20-30 min; 5) collecting the filtrate, concentrating under reduced pressure, and vacuum drying to obtain quercetin. The quercetin product prepared by the invention has high purity and low production cost, and is suitable for industrial production.
Description
Technical Field
The invention belongs to the field of extraction of effective components, and particularly relates to a preparation method for extracting quercetin from parasitic loranthus.
Background
Sang Ji Sheng is called peach Loranthus and Chi Lian Ji, etc. The twigs and the leaves are densely covered with brown or rufous-shaped hairs, and sometimes have scattered piled-up star-shaped hairs, and the twigs are black and have no hairs and scattered skin holes. Produced in Yunnan, Sichuan, Gansu, Shaanxi, Shanxi, Henan, Guizhou, Hubei, Hunan, etc. Has effects of dispelling pathogenic wind and dampness, benefiting liver and kidney, strengthening tendons and bones, and preventing miscarriage. The herba Taxilli contains quercetin as effective component.
Quercetin, chemically known as 2- (3, 4-dihydroxyphenyl) -3,5, 7-trihydroxy-1-benzopyran-4-one, is soluble in certain acids, such as glacial acetic acid, from its chemical structure, and its alkaline aqueous solution is often yellow in color and is hardly soluble in water. Can be used as medicine, and has effects of relieving cough and asthma and eliminating phlegm. In recent years, it is found that quercetin has a remarkable effect in scavenging free radicals, and is one of active ingredients of medicinal plants, and related pharmacology and clinical experiments prove that quercetin has a wide medicinal value, such as a certain effect in inhibiting cancer cells of breast cancer, liver cancer and the like, and also has a remarkable curative effect in cardiovascular protection, virus resistance and the like. In addition, it can also be used for treating chronic bronchitis, coronary heart disease, hypertension, etc.
Disclosure of Invention
The invention aims to provide an extraction method for extracting quercetin from parasitic loranthus, wherein the quercetin has wide medicinal value.
The invention is completed by the following technical scheme:
1) pulverizing dried herba Taxilli raw material, sieving with 30-60 mesh sieve, and collecting coarse powder;
2) degreasing: weighing a certain amount of coarse powder, and adding the coarse powder into the mixture according to a material-liquid ratio of 1: 3-5, soaking in petroleum ether solution, and placing in a constant temperature water bath at 70-90 deg.C for degreasing and decolorizing for 60-90 min;
3) recovering petroleum ether from the treated degreasing solution, collecting the filter residue of the parasitic loranthus, and drying the filter residue in a drying oven at 60 ℃;
4) putting the weighed filter residue with a certain mass into 70-90% of absolute ethyl alcohol solution according to the material-liquid ratio of 1:3-10, placing the device in microwave for treatment, and performing suction filtration treatment after 20-30 min;
5) collecting the filtrate, concentrating under reduced pressure, and vacuum drying to obtain quercetin.
2. The method for preparing quercetin from parasitic loranthus according to claim 1, wherein the oven treatment time in step 3) is 30-50 min.
3. The method according to claim 1, wherein the step 4) of extracting quercetin from Taxus chinensis is carried out by microwave-assisted extraction with an extraction power of 250W and a treatment time of 20-30 min.
The present invention will be further described with reference to specific embodiments, but the scope of the invention as claimed is not limited to the following embodiments.
The specific implementation mode is as follows:
example 1:
crushing a certain mass of dried parasitic loranthus raw material, sieving the crushed parasitic loranthus raw material by a 30-mesh sieve, and collecting coarse powder for later use; weighing a certain amount of coarse powder, and adding the coarse powder into the mixture according to a material-liquid ratio of 1:3, soaking in petroleum ether solution, and placing in a constant-temperature water bath kettle at 70 ℃ for degreasing and decoloring for 90 min; recovering petroleum ether from the treated degreasing solution, collecting the filter residue of the parasitic loranthus, and drying the filter residue in a drying oven at 60 ℃; putting the weighed filter residue with a certain mass into an 80% absolute ethyl alcohol solution according to a material-liquid ratio of 1:5, putting the device into microwave for treatment, and performing suction filtration treatment after 25 min; collecting the filtrate, concentrating under reduced pressure, and vacuum drying to obtain quercetin.
Example 2:
crushing a certain mass of dried parasitic loranthus raw material, sieving the crushed parasitic loranthus raw material by a 60-mesh sieve, and collecting coarse powder for later use; weighing a certain amount of coarse powder, and adding the coarse powder into the mixture according to a material-liquid ratio of 1:3, soaking in petroleum ether solution, and placing in a constant-temperature water bath kettle at 80 ℃ for degreasing and decoloring for 70 min; recovering petroleum ether from the treated degreasing solution, collecting the filter residue of the parasitic loranthus, and drying the filter residue in a drying oven at 60 ℃; putting the weighed filter residue with a certain mass into a 90% absolute ethyl alcohol solution according to a material-liquid ratio of 1:3, putting the device into microwave for treatment, and performing suction filtration treatment after 20 min; collecting the filtrate, concentrating under reduced pressure, and vacuum drying to obtain quercetin.
Example 3:
crushing a certain mass of dried parasitic loranthus raw material, sieving the crushed parasitic loranthus raw material by a 60-mesh sieve, and collecting coarse powder for later use; weighing a certain amount of coarse powder, and adding the coarse powder into the mixture according to a material-liquid ratio of 1:5, soaking in petroleum ether solution, and placing in a constant-temperature water bath kettle at 80 ℃ for degreasing and decoloring for 80 min; recovering petroleum ether from the treated degreasing solution, collecting the filter residue of the parasitic loranthus, and drying the filter residue in a drying oven at 60 ℃; putting the weighed filter residue with a certain mass into 70% absolute ethyl alcohol solution according to the material-liquid ratio of 1:5, putting the device into microwave for treatment, and performing suction filtration treatment after the treatment for 30 min; collecting the filtrate, concentrating under reduced pressure, and vacuum drying to obtain quercetin.
Claims (3)
1. A preparation method for extracting quercetin from parasitic loranthus is characterized by comprising the following steps:
1) pulverizing dried herba Taxilli raw material, sieving with 30-60 mesh sieve, and collecting coarse powder;
2) degreasing: weighing a certain amount of coarse powder, and adding the coarse powder into the mixture according to a material-liquid ratio of 1: 3-5, soaking in petroleum ether solution, and placing in a constant temperature water bath at 70-90 deg.C for degreasing and decolorizing for 60-90 min;
3) recovering petroleum ether from the treated degreasing solution, collecting the filter residue of the parasitic loranthus, and drying the filter residue in a drying oven at 60 ℃;
4) putting the weighed filter residue with a certain mass into 70-90% of absolute ethyl alcohol solution according to the material-liquid ratio of 1:3-10, placing the device in microwave for treatment, and performing suction filtration treatment after 20-30 min;
5) collecting the filtrate, concentrating under reduced pressure, and vacuum drying to obtain quercetin.
2. The method for preparing quercetin from parasitic loranthus according to claim 1, wherein the oven treatment time in step 3) is 30-50 min.
3. The method according to claim 1, wherein the step 4) of extracting quercetin from Taxus chinensis is carried out by microwave-assisted extraction with an extraction power of 250W and a treatment time of 20-30 min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811374150.3A CN111196796A (en) | 2018-11-19 | 2018-11-19 | A method for extracting quercetin from herba Taxilli |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811374150.3A CN111196796A (en) | 2018-11-19 | 2018-11-19 | A method for extracting quercetin from herba Taxilli |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111196796A true CN111196796A (en) | 2020-05-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811374150.3A Pending CN111196796A (en) | 2018-11-19 | 2018-11-19 | A method for extracting quercetin from herba Taxilli |
Country Status (1)
| Country | Link |
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| CN (1) | CN111196796A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112322422A (en) * | 2020-11-25 | 2021-02-05 | 梧州学院 | Parasitic loranthus rice wine and brewing method thereof |
| CN112471509A (en) * | 2020-11-25 | 2021-03-12 | 梧州学院 | Loranthus parasiticus syrup with high quercetin content and preparation method thereof |
-
2018
- 2018-11-19 CN CN201811374150.3A patent/CN111196796A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112322422A (en) * | 2020-11-25 | 2021-02-05 | 梧州学院 | Parasitic loranthus rice wine and brewing method thereof |
| CN112471509A (en) * | 2020-11-25 | 2021-03-12 | 梧州学院 | Loranthus parasiticus syrup with high quercetin content and preparation method thereof |
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| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20200526 |
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| WD01 | Invention patent application deemed withdrawn after publication |