CN111195334A - A topical Chinese medicinal composition for treating acne, and its preparation method - Google Patents
A topical Chinese medicinal composition for treating acne, and its preparation method Download PDFInfo
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- CN111195334A CN111195334A CN202010217154.1A CN202010217154A CN111195334A CN 111195334 A CN111195334 A CN 111195334A CN 202010217154 A CN202010217154 A CN 202010217154A CN 111195334 A CN111195334 A CN 111195334A
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Abstract
A topical Chinese medicinal composition for treating acne and its preparation method, the raw material composition is 10-50 parts of radix Sophorae Flavescentis, 10-50 parts of cortex Dictamni Radicis, 5-30 parts of radix Stemonae, 5-15 parts of cortex Phellodendri, 1-8 parts of radix et rhizoma Rhei, and 1-10 parts of caulis Sargentodoxae. The method comprises the following steps: (1) preparing raw materials; (2) soaking radix Sophorae Flavescentis, cortex Dictamni Radicis, radix Stemonae and cortex Phellodendri in water, and extracting to obtain radix Sophorae Flavescentis extractive solution, cortex Dictamni Radicis extractive solution, radix Stemonae extractive solution and cortex Phellodendri extractive solution; (3) mixing radix Sophorae Flavescentis extractive solution, cortex Dictamni Radicis extractive solution, radix Stemonae extractive solution and cortex Phellodendri extractive solution, and filtering to obtain purified filtrate; (4) evaporating and concentrating; (5) drying radix et rhizoma Rhei and caulis Sargentodoxae, grinding, and micronizing; (6) putting the mixed powder into the concentrated solution, and adding a preservative and a humectant; and dispersing, homogenizing, shearing and refining the mixed materials by a homogenizing emulsifying machine to prepare the paste. The method can effectively improve the production efficiency, reduce the loss of the effective components of the medicine and enhance the medicine effect; the product is convenient to carry and use and has better market prospect.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine, and relates to an external traditional Chinese medicine composition for treating acne and a preparation method thereof.
Background
Acne is a common chronic inflammatory skin disease which is frequently found in facial follicular sebum units of teenagers, has certain damage capacity, is better found in young men and women of 15-30 years old, and is clinically mainly manifested by polymorphic skin lesions such as facial acne, papules, pustules, nodules and the like, and is frequently found in parts rich in sebaceous glands such as the face, the back, the chest and the like. Acne occurs mainly in association with factors such as hyperseborrhea, blockage of pilosebaceous ducts, bacterial infection and inflammatory reaction; after adolescence, the androgen level in the human body is increased, sebaceous glands are developed vigorously and a large amount of sebum is produced. Abnormal keratinization of the pilosebaceous canal can cause blockage of the canal, obstruction of sebum discharge, and formation of keratotic plugs, i.e., comedones. A number of microorganisms in the hair follicle (especially propionibacterium acnes) multiply, producing lipases, decomposing sebum, producing free fatty acids, which in turn chemotact inflammatory cells and mediators, inducing and exacerbating the inflammatory response. Because acne is well developed in adolescence, the personal image is seriously influenced, and psychological problems such as anxiety, depression and the like can be brought to patients, particularly teenagers.
At present, modern medicine is mainly applied to the treatment of medicines such as vitamin A acid, antibiotics, hormones and the like, but certain drug resistance and adverse drug reactions exist, and the effective rate is not ideal. At present, a plurality of traditional Chinese medicine external treatment products for treating acne exist in the market, and in the preparation process, most products adopt a single extraction mode or a mode of simply crushing and adding a solvent for mixed use, so that the content of the effective ingredients of the medicines in the products is low, or the water-insoluble ingredients are lost due to the limitation of the extraction process of the effective ingredients; or due to the volume and dosage of the raw medicinal materials, the product contains more lignin and cellulose, so that the content of the effective components of the medicine in unit volume is low, thereby affecting the curative effect and being inconvenient to use.
Disclosure of Invention
The invention aims to provide an external traditional Chinese medicine composition for treating acne and a preparation method thereof.
The external traditional Chinese medicine composition for treating acne comprises 10-50 parts of radix sophorae flavescentis, 10-50 parts of cortex dictamni, 5-30 parts of radix stemonae, 5-15 parts of cortex phellodendri, 1-8 parts of rheum officinale and 1-10 parts of sargentgloryvine stem.
The external traditional Chinese medicine composition for treating acne comprises 20-40 parts of radix sophorae flavescentis, 20-40 parts of cortex dictamni, 10-20 parts of radix stemonae, 6-12 parts of cortex phellodendri, 2-5 parts of rheum officinale and 3-8 parts of sargentgloryvine stem.
The raw material components of the external traditional Chinese medicine composition for treating acne are 30 parts of radix sophorae flavescentis, 30 parts of cortex dictamni, 15 parts of radix stemonae, 10 parts of cortex phellodendri, 3 parts of rheum officinale and 6 parts of sargentgloryvine stem.
The preparation method of the external traditional Chinese medicine composition for treating acne comprises the following steps:
1. preparing raw materials according to the raw material component proportion;
2. soaking radix Sophorae Flavescentis, cortex Dictamni Radicis, radix Stemonae and cortex Phellodendri in water for at least 2 hr, and respectively extracting with water under normal pressure, negative pressure or ultrasonic wave to obtain radix Sophorae Flavescentis extractive solution, cortex Dictamni Radicis extractive solution, radix Stemonae extractive solution and cortex Phellodendri extractive solution;
3. mixing radix Sophorae Flavescentis extractive solution, cortex Dictamni Radicis extractive solution, radix Stemonae extractive solution and cortex Phellodendri extractive solution, and filtering to remove residue, ash and macromolecular compounds to obtain purified filtrate;
4. heating the purified filtrate, evaporating and concentrating to obtain a concentrate;
5. drying the rhubarb and the sargentgloryvine stem in the raw materials to remove water, then crushing, and carrying out ultrafine crushing by using an ultrafine crusher until the particle size is less than or equal to 40 microns to prepare ultrafine mixed powder;
6. putting the mixed powder into the concentrated solution, and adding a preservative and a humectant to obtain a mixed material; dispersing and homogenizing the mixed materials by adopting a homogenizing emulsifying machine at a stirring speed of 2000-4000 revolutions per minute, and then shearing and refining the mixed materials by adopting a stirring speed of 6000-9000 revolutions per minute to prepare paste so as to obtain the external traditional Chinese medicine composition for treating acne.
In the step 2, when the normal pressure extraction, the negative pressure extraction or the ultrasonic extraction is performed, the mass ratio of the kuh-seng, the cortex dictamni, the radix stemonae or the cortex phellodendri to the water is 1: (8-10), extracting for 2 times, and mixing the liquid obtained after the two-time extraction to obtain a radix sophorae flavescentis extracting solution, a cortex dictamni extracting solution, a radix stemonae extracting solution and a cortex phellodendri extracting solution; wherein, the normal pressure extraction adopts traditional Chinese medicine normal pressure reflux extraction equipment, and the extraction time is 1.5-2.0 hours each time; the negative pressure extraction adopts traditional Chinese medicine vacuum extraction equipment, the extraction time is 1.0-1.5 hours each time, and the working pressure during extraction is-0.06-0.08 MPa; traditional Chinese medicine ultrasonic extraction equipment is adopted for ultrasonic extraction, and the extraction time is 25-35 minutes each time.
In the step 2, when the normal pressure extraction or the negative pressure extraction is carried out, the radix sophorae flavescentis, the cortex dictamni, the radix stemonae and the cortex phellodendri are in a sheet shape; when ultrasonic extraction is carried out, radix Sophorae Flavescentis, cortex Dictamni Radicis, radix Stemonae and cortex Phellodendri are firstly pulverized to particle size of below 5 mm.
In the step 3, the filtration is sequentially performed by adopting a centrifugal filter for rough filtration, ceramic membrane ultrafiltration and hollow fiber membrane nanofiltration; the molecular weight of the substance in the obtained purified filtrate is less than 10000.
In the step 4, a steam boiler, a single-effect evaporator or a multi-effect evaporator is adopted for evaporation concentration, and the mass of the obtained concentrate is 20-25% of the total mass of the purified filtrate.
In the step 5, the dried material is firstly crushed, then the part below 60 meshes is screened out to be used as primary powder, the material on the screen is continuously ground to be below 80 meshes to be used as secondary powder, and the primary powder and the secondary powder are mixed for superfine grinding.
In the step 6, the preservative is ethylparaben, and the addition amount of the preservative is less than 0.02 percent of the total mass of the mixed materials; the humectant is sodium carboxymethylcellulose, and the addition amount of the humectant is 2-3% of the total mass of the mixed material.
In the step 6, the external traditional Chinese medicine composition for treating acne is filled by a full-automatic filling machine, and is quantitatively packaged by a medical aluminum ointment tube, a single paper small box of a hose is used for packaging, and the product is cased and sterilized.
The application method of the external traditional Chinese medicine composition for treating acne comprises the following steps: the topical Chinese medicinal composition for treating acne is applied to affected part surface once in the morning and at night, covered for at least 30 min, and washed off with water for 7 days as a treatment course.
The principle of the method of the invention is as follows: determining water extraction and powder types by referring to the volume of raw materials and the solubility of active ingredients, and determining the raw material dosage of each process by referring to the ratio of different raw medicines to the extraction dosage; extracting the raw materials of the lightyellow sophora root, the dittany bark, the sessile stemona root and the amur corktree bark which have high lignin and cellulose components and large volume and water-soluble active ingredients with water, preparing the rest components into superfine powder, wherein the superfine powder meets the wall-breaking design parameter of plant cells with the diameter of 20-100 nm, and is beneficial to increasing the absorption of the active ingredients of the traditional Chinese medicine, shortening the onset time and enhancing the efficacy;
the main raw materials have the following effects and pharmacological effects:
radix Sophorae Flavescentis is dried root of Sophora flavescens ait of Leguminosae; nature and taste: bitter and cold; meridian tropism to heart, liver, stomach, large intestine and bladder meridians; has the effects of clearing heat, eliminating dampness and killing parasites; kuh-seng contains various alkaloids: d-matrine, d-oxymatrine, sophocarpol l-fetida alkali, l-methyl laburnine, l-anabasine and sophocarpine; also contains flavonoid: xanthohumol, isoxanthohumol, 3, 4', 5-trihydroxy-7-methoxy-8-isopentenyl flavone, 8-isopentenyl kaempferol, etc.; modern pharmacological studies show that the radix sophorae flavescentis has the following pharmacological effects: (1) the anti-pathogen effect is as follows: the kushen water decoction has obvious inhibition effect on escherichia coli, staphylococcus aureus, streptococcus A, streptococcus B, dysentery bacillus, salmonella vilmorii and proteus (2) immunosuppression effect: matrine and oxymatrine have inhibition effect on mouse immunity under 1/5LD50 dosage; (3) anti-allergic effect: matrine can reduce the release of allergic medium, and is an immunosuppressant;
cortex Dictamni Radicis is dried root bark of Dictamnus dasycarpus Turcz of Rutaceae; nature and taste: bitter and cold; meridian tropism: spleen, stomach and bladder meridians entered; has the effects of clearing heat, eliminating dampness, dispelling pathogenic wind and removing toxic substances; cortex Dictamni Radicis contains dictamnine, dictamnolide, sitosterol, phellodendron ketoacid, trigonelline, choline, and fraxinellone; also contains campesterol, skimmine, gamma-thujatine, and dittanine; modern pharmacological studies show that the cortex dictamni has the following pharmacological actions: (1) the antibacterial effect is as follows: the cortex dictamni extract has the strongest inhibition effect on staphylococcus, escherichia coli, common proteus and bacillus subtilis, and the main antibacterial substances are dictamnine and fraxinellone; in vitro test 1: 4, the water extract has different degrees of inhibition effects on various pathogenic fungi such as trichophyton violaceum, trichophyton concentricum and trichophyton schoenleinii, (2) anti-inflammatory and anti-allergic effects: the methanol extract of cortex Dictamni Radicis can inhibit the weight gain and thickening of CD rat ear caused by dinitrofluorobenzene, and has obvious inhibition effect on mouse anti-sheep erythrocyte antibody; the cortex dictamni water extract is administrated after antigen attack, and can generate inhibition effect on contact dermatitis (ear swelling) caused by hapten 2, 4, 6-trinitrochlorobenzene and foot rubbing reaction (foot swelling) caused by particulate antigen sheep red blood cells; (3) antioxidation: the cortex dictamni extract can effectively remove free radicals;
stemona is dried root tuber of Stemona sessilifolia (Miq.) Miq, Stemona japonica (Bl.) Miq, or Stemona tuberosa Lour; nature and taste: sweet, bitter and slightly warm; meridian tropism: entering lung meridian; has little toxicity; has the insecticidal efficacy; radix Stemonae contains stemonine, isobutronine, protostemonine, stemonine, and warfarin; modern pharmacological research shows that the stemona root has an antibacterial effect: in vitro test, radix Stemonae decoction and radix Stemonae ethanol extract have antibacterial effect on various pathogenic bacteria such as pneumococcus, type B hemolytic streptococcus, meningococcus, Staphylococcus aureus, Staphylococcus albus and Shigella dysenteriae, typhoid bacillus, paratyphoid bacillus, Escherichia coli, Proteus bacillus, diphtheria bacillus, pneumonia bacillus, plague bacillus, Bacillus anthracis, Bacillus subtilis, Vibrio cholerae, and human type tubercle bacillus;
phellodendron bark is dried bark of Phellodendron chinense Schneid or Phellodendron amurense amprense Rupr of Rutaceae, the characteristics of bitter and cold properties, channel tropism, kidney and bladder channel, and the functions of clearing heat, eliminating dampness, removing toxicity and curing sore, the Phellodendron bark contains berberine, jateorhizine, magnoflorine, phellodendrine, N-methyl barley bud alkali, tetrandrine, menine and menine, and the like, and the Phellodendron bark contains Phellodendron ketone, Phellodendron lactone, dictamnus, Phellodendron ketoacid, green fluorescent acid, 7-dehydrostigmasterol, β -sitosterol and campesterol, the root bark contains berberine, jateorhizine, phellodendrine and N-methyl barley bud alkali, the modern pharmacological research shows that the Phellodendron bark has the following pharmacological actions (1) antibacterial action which has strong inhibiting effect on in vitro tests on staphylococcus, pneumococcus, diphtheria, streptococcus grasseridis, vibrio dysenteriae, streptococcus faecium, streptococcus mitis, mouse, rat interferon, mouse interferon, mouse, mouse and mouse, mouse and mouse, mouse;
the rhubarb is Rheum palmatum L of Polygonaceae, dried root and rhizome of Rheum tanguticum Maxim and ex Balf or Rheum officinale Baill, which have bitter and cold natures, channel tropism, spleen, stomach, large intestine, liver and pericardium and the effects of clearing away heat and toxic materials, cooling blood and removing stasis, contains about 3% of anthraquinone compounds including free and combined chrysophanol, rhein, aloe emodin, centipede enteromorph, physcion, and further contains about 5% of tannin, free gallic acid, cinnamic acid and lipid thereof, and the like, and the modern pharmacological research shows that the rhubarb has the following pharmacological effects of (1) antibacterial action, namely the rhubarb has different degrees of inhibition on various bacteria, including staphylococcus aureus, pseudomonas aeruginosa, dysentery bacillus kappa, escherichia coli and the like, wherein the antibacterial mechanism is most sensitive to staphylococcus aureus, the antibacterial action can mainly be used for destroying the antibacterial action of Rheum palmatum, the antibacterial action can be used for inhibiting the formation of the thrombocyte, especially the myocardial infarction, myocardial infarction;
the sargentgloryvine stem is a dried rattan of Sargentodoxa cuneata (Oliv.) Rehd.et wils, belonging to the family Lardizabalaceae, has bitter and neutral properties, and has the functions of clearing heat, removing toxicity, promoting blood circulation and dispelling wind, and the sargentgloryvine stem contains emodin, physcion, β -sitosterol, daucosterol, stearic acid, salidroside, dextroeugenol diglucoside, dextrodihydroguaiaretic acid, chrysophanol, vanillic acid, protocatechuic acid, coumaric acid-p-hydroxyphenylethyl acetate and sargentgloryvine polysaccharide, and the modern pharmacological research shows that the sargentgloryvine stem has the pharmacological effects of (1) bacteriostasis, namely, the panoply disc test, 25% decoction has extremely sensitive bacteriostasis on staphylococcus aureus and streptococcus, has high sensitivity on escherichia coli, pseudomonas aeruginosa, streptococcus alpha, catarrhalis and staphylococcus albus, and the anti-inflammatory and immunosuppressive effects, the anti-inflammatory effects of sargentgloryvine stem has the wide anti-inflammatory effect, the anti-inflammatory effect on the beta cell, the serum of sargentgloryvine stem, the anti-secretory effect of the sargentgloryvine stem, the anti-beta cell, the anti-rat, the anti-inflammatory effect of the sargentodophyllostachys stem, the anti-toxin, the anti-inflammatory effect of the serum, the anti-inflammatory effect of the serum, the serum of the extracted sargentodophyllostachymus stem, and the extracted effective part, and the anti-beta cell of the anti-toxin, the anti-beta-toxin, the anti-inflammatory effect of the extracted sargent cell, and the extracted sargent cell of the extracted;
the traditional Chinese medicine holds that the causes of acne, external wind evil and intrinsic heat of lung channels; accumulation of damp-heat and accumulation of phlegm-dampness; toxic heat is combined, and liver and kidney yin deficiency occurs; disharmony of thoroughfare and conception vessels is involved. From the perspective of external treatment of traditional Chinese medicine, the main pathogenesis factors of acne are heat, dampness and wind, and the long course of disease can be accompanied by blood stasis. In the externally applied traditional Chinese medicine composition, the lightyellow sophora root, the densefruit pittany root-bark and the amur corktree bark clear heat and dry dampness, the rhubarb and the sargentgloryvine stem clear heat and detoxify and remove blood stasis, the densefruit pittany root-bark and the sargentgloryvine stem dispel wind, and the lightyellow sophora root and the sessile. The Chinese medicinal composition can be used for treating acne with synergistic effect on heat, dampness, wind and blood stasis in the pathogenesis of acne.
From the perspective of modern traditional Chinese medicine pharmacology, the external traditional Chinese medicine composition has a multi-aspect synergistic effect on the treatment of acne, can effectively inhibit bacteria, relieve skin inflammatory reaction and promote skin damage repair: (1) the antibacterial effect is as follows: the traditional Chinese medicine composition has antibacterial effects of different degrees of all components; (2) anti-inflammatory, anti-allergic, immunosuppressive effects: the sophora flavescens, the cortex dictamni, the golden cypress, the rheum officinale and the sargentgloryvine stem have anti-inflammatory, anti-allergic and immunosuppressive effects, and can effectively improve inflammatory reaction of acne and various allergic/allergic reactions combined with the acne; (3) antioxidation: the rhubarb, the sargentgloryvine stem and the cortex dictamni have antioxidant activity and are beneficial to protecting damaged tissues; (4) and (3) cycle improvement: the rhubarb and the sargentgloryvine stem have the function of improving local circulation and are beneficial to repairing skin lesion tissues; the oxidation resistance and the circulation improvement of the rhubarb and the sargentgloryvine stem are the specific expression of the heat clearing and the blood activating effects in the traditional Chinese medicine;
from the aspect of preparation technology, the invention provides a preparation method of a traditional Chinese medicine composition for treating acne by combining water extraction and powder on the basis of referring to the volume of raw materials and the solubility of active ingredients; in the formula of the traditional Chinese medicine composition for treating acne, the external effective dose and unit weight volume of the raw materials of radix sophorae flavescentis, cortex dictamni, radix stemonae and cortex phellodendri are large, and the drug effect can be exerted by a water extraction mode, so the water extraction mode is selected for extraction; the unit weight volumes of the rhubarb and the sargentgloryvine stem raw materials are relatively smaller, and partial active ingredients are insoluble in water, so the rhubarb and the sargentgloryvine stem raw materials are prepared in a powder form; on one hand, compared with a method for external use by simple crushing, the preparation method combining water extraction and powder can reduce the proportion of ineffective components such as lignin, cellulose and the like in a unit weight product, improve the relative content of effective components and achieve better curative effect; on the other hand, compared with a preparation method by pure water extraction, the water-insoluble active ingredients are reserved, more active ingredients are reserved in the product, the multi-mechanism curative effect is exerted, more active ingredients of multiple same and similar mechanisms are reserved, and the synergistic effect is realized, so that the curative effect is stronger; on the basis, the invention applies various modern preparation processes, can effectively improve the production efficiency, reduce the loss of active ingredients of the medicine and enhance the medicine effect; the produced product is convenient to carry and use, and has a good market prospect.
The ointment prepared from the external traditional Chinese medicine composition is used for treating acne, and most skin lesions can be obviously relieved within 1 month.
Detailed Description
In the embodiment of the invention, cobalt 60 sterilization equipment (Liaoning farm hospital sterilization detection center) is adopted for sterilization.
The traditional Chinese medicine normal-pressure reflux extraction equipment adopted in the embodiment of the invention is a ZTH100L traditional Chinese medicine normal-pressure reflux extraction tank, the traditional Chinese medicine vacuum extraction equipment is a ZTH50L traditional Chinese medicine vacuum extraction tank, and the traditional Chinese medicine ultrasonic extraction equipment is a TNH100L traditional Chinese medicine ultrasonic extractor.
The steam pot adopted in the embodiment of the invention is a WKT-100L electric steam pot, the single-effect evaporator is a WZ500 single-effect evaporation concentrator, and the multi-effect evaporator is a WZ500 triple-effect evaporation concentrator.
In the embodiment of the invention, the mass content of water in the concentrate is 10-15%.
The following are preferred embodiments of the present invention, which are only used for explaining the present invention and do not limit the scope of the claims, and other alternative means that can be conceived by those skilled in the art from the description should be within the scope of the claims of the present invention.
Example 1
The external traditional Chinese medicine composition for treating acne comprises 30 parts of radix sophorae flavescentis, 30 parts of cortex dictamni, 15 parts of radix stemonae, 10 parts of cortex phellodendri, 3 parts of rheum officinale and 6 parts of sargentgloryvine stem;
the preparation method comprises the following steps:
preparing raw materials according to the raw material component proportion;
soaking radix Sophorae Flavescentis, cortex Dictamni Radicis, radix Stemonae and cortex Phellodendri in water for at least 2 hr, and extracting with water as solvent under normal pressure to obtain radix Sophorae Flavescentis extractive solution, cortex Dictamni Radicis extractive solution, radix Stemonae extractive solution and cortex Phellodendri extractive solution; the mass ratio of the lightyellow sophora root, the dittany bark, the sessile stemona root or the amur corktree bark to the water is 1: 8, extracting for 2 times, and mixing the liquid obtained after the two-time extraction to obtain a radix sophorae flavescentis extracting solution, a cortex dictamni extracting solution, a radix stemonae extracting solution and a cortex phellodendri extracting solution; the extraction time is 1.5-2.0 hours each time; radix Sophorae Flavescentis, cortex Dictamni Radicis, radix Stemonae and cortex Phellodendri are in sheet form;
mixing radix Sophorae Flavescentis extractive solution, cortex Dictamni Radicis extractive solution, radix Stemonae extractive solution and cortex Phellodendri extractive solution, and filtering to remove residue, ash and macromolecular compounds to obtain purified filtrate; filtering by adopting a centrifugal filter for rough filtration, ceramic membrane ultrafiltration and hollow fiber column nanofiltration in sequence; the molecular weight of the substance in the obtained purified filtrate is less than 10000;
heating the purified filtrate, evaporating and concentrating to obtain a concentrate; the mass of the concentrate is 20% of the total mass of the purified filtrate;
drying rhubarb and sargentgloryvine stem in raw materials to remove moisture, firstly crushing, then screening out a part below 60 meshes as primary powder, continuously grinding the oversize material to below 80 meshes as secondary powder, mixing the primary powder and the secondary powder, and carrying out ultrafine grinding by using an ultrafine grinder until the particle size is less than or equal to 40 microns to prepare ultrafine mixed powder;
putting the mixed powder into the concentrated solution, and adding a preservative and a humectant to obtain a mixed material; the preservative is ethylparaben, and the addition amount of the ethylparaben is 0.02 percent of the total mass of the mixed materials; the humectant is sodium carboxymethylcellulose, and the adding amount of the humectant is 2% of the total mass of the mixed material; dispersing and homogenizing the mixed materials by adopting a homogenizing emulsifying machine at a stirring speed of 2000-4000 revolutions per minute, and then shearing and refining the mixed materials by adopting a stirring speed of 6000-9000 revolutions per minute to prepare paste so as to obtain the external traditional Chinese medicine composition for treating acne; filling is finished by a full-automatic filling machine, medicinal aluminum ointment tubes are used for quantitative packaging, the tubes are packaged in single paper small boxes, products are packed in the outer box type, and then sterilization treatment is carried out;
retrospective study is carried out on 22 volunteers of acne cases in Beijing City, Shenyang City and Fushun City of Liaoning province from 1 month to 12 months in 2019, wherein 16 female patients, 6 male patients, 12-43 years old (22.5 +/-7.812 years on average) and 3-25 years old (46.45 +/-75.962 months on average) are treated by traditional Chinese medicine external treatment according to the formula of the traditional Chinese medicine composition; after 4-8 weeks of follow-up, calculating skin damage scores according to the number of skin damages of patients in curative effect judgment, wherein each acne score is 0.5, each pimple score is 1, and each nodule score is 3; the skin lesion regression rate ═ [ (pre-treatment skin lesion score-post-treatment skin lesion score)/pre-treatment skin lesion score ] × 100%; and (3) healing: the skin damage regression rate is more than 95 percent; the effect is shown: the skin damage fading rate is 71-95%; the method has the following advantages: the skin damage fading rate is 50-70%; and (4) invalidation: the skin loss regression rate is less than 50% or increased; after 8 weeks of treatment, the effective rate of the external traditional Chinese medicine composition for treating the acne reaches 91 percent; wherein the healing, obvious effect, effective and ineffective after 2 weeks are respectively 3, 6, 9 and 4, and the total effective rate is 81.8%; the healing, obvious effect, effective and ineffective after 4 weeks are respectively 8, 4 and 2, and the total effective rate is 91 percent; the healing, obvious effect, effective and ineffective after 8 weeks are respectively 12 cases, 6 cases, 2 cases and 2 cases, and the total effective rate is 91 percent.
Example 2
The external traditional Chinese medicine composition for treating acne comprises the raw material components of 20 parts of radix sophorae flavescentis, 40 parts of cortex dictamni, 10 parts of radix stemonae, 12 parts of cortex phellodendri, 2 parts of rheum officinale and 8 parts of sargentgloryvine stem;
the preparation method is the same as example 1, and is different from the following steps:
(1) respectively carrying out negative pressure extraction, wherein the mass ratio of the kuh-seng, the cortex dictamni, the radix stemonae or the cortex phellodendri to the water is 1: 9; the extraction time is 1.0-1.5 hours each time, and the working pressure during extraction is-0.06-0.08 MPa;
(2) the mass of the concentrate is 22% of the total mass of the purified filtrate;
(3) the addition amount of the preservative is 0.01 percent of the total mass of the mixed materials; the adding amount of the humectant accounts for 3 percent of the total mass of the mixed materials; firstly, dispersing and homogenizing at a stirring speed of 3000 r/min, and then shearing and thinning at a stirring speed of 7000 r/min to prepare the paste.
Example 3
The external traditional Chinese medicine composition for treating acne comprises the raw material components of 40 parts of radix sophorae flavescentis, 20 parts of cortex dictamni, 20 parts of radix stemonae, 6 parts of cortex phellodendri, 5 parts of rheum officinale and 3 parts of sargentgloryvine stem;
the preparation method is the same as example 1, and is different from the following steps:
(1) respectively carrying out ultrasonic extraction, wherein the mass ratio of the kuh-seng, the cortex dictamni, the radix stemonae or the cortex phellodendri to the water is 1: 9, extracting for 25-35 minutes each time; extracting radix Sophorae Flavescentis, cortex Dictamni Radicis, radix Stemonae and cortex Phellodendri, pulverizing to particle size below 5 mm;
(2) the mass of the concentrate is 24% of the total mass of the purified filtrate;
(3) the addition amount of the preservative is 0.01 percent of the total mass of the mixed materials; the adding amount of the humectant accounts for 3 percent of the total mass of the mixed materials; firstly, the mixture is dispersed and homogenized at the stirring speed of 4000 revolutions per minute, and then the mixture is sheared and refined at the stirring speed of 8000 revolutions per minute to prepare the paste.
Example 4
The external traditional Chinese medicine composition for treating acne comprises the raw material components of 40 parts of radix sophorae flavescentis, 40 parts of cortex dictamni, 20 parts of radix stemonae, 6 parts of cortex phellodendri, 2 parts of rheum officinale and 3 parts of sargentgloryvine stem;
the preparation method is the same as example 1, and is different from the following steps:
(1) the mass ratio of the kuh-seng, the cortex dictamni, the radix stemonae or the cortex phellodendri to the water is 1: 10;
(2) the mass of the concentrate is 25% of the total mass of the purified filtrate;
(3) the addition amount of the preservative is 0.01 percent of the total mass of the mixed materials; the adding amount of the humectant accounts for 2 percent of the total mass of the mixed materials; firstly, the mixture is dispersed and homogenized at the stirring speed of 4000 revolutions per minute, and then the mixture is sheared and refined at the stirring speed of 8000 revolutions per minute to prepare the paste.
Example 5
The external traditional Chinese medicine composition for treating acne comprises the raw material components of 20 parts of radix sophorae flavescentis, 20 parts of cortex dictamni, 10 parts of radix stemonae, 12 parts of cortex phellodendri, 5 parts of rheum officinale and 8 parts of sargentgloryvine stem;
the preparation method is the same as example 1, and is different from the following steps:
(1) respectively extracting the sophora flavescens, the cortex dictamni, the stemona or the phellodendron bark by negative pressure, wherein the mass ratio of the water to the sophora flavescens, the cortex dictamni, the stemona or the phellodendron bark is 1: 10, the extraction time is 1.0 to 1.5 hours each time, and the working pressure during extraction is-0.06 to-0.08 MPa;
(2) the mass of the concentrate is 25% of the total mass of the purified filtrate;
(3) the addition amount of the preservative is 0.01 percent of the total mass of the mixed materials; the adding amount of the humectant accounts for 3 percent of the total mass of the mixed materials; firstly, the mixture is dispersed and homogenized at the stirring speed of 4000 revolutions per minute, and then the mixture is sheared and refined at the stirring speed of 9000 revolutions per minute to prepare the paste.
Claims (10)
1. A topical Chinese medicinal composition for treating acne is characterized by comprising 10-50 parts of radix sophorae flavescentis, 10-50 parts of cortex dictamni, 5-30 parts of radix stemonae, 5-15 parts of cortex phellodendri, 1-8 parts of rheum officinale and 1-10 parts of sargentgloryvine stem.
2. The external traditional Chinese medicine composition for treating acne according to claim 1, which is characterized by comprising 20-40 parts of radix sophorae flavescentis, 20-40 parts of cortex dictamni, 10-20 parts of radix stemonae, 6-12 parts of cortex phellodendri, 2-5 parts of rheum officinale and 3-8 parts of sargentgloryvine stem.
3. The external traditional Chinese medicine composition for treating acne according to claim 1, which is characterized in that the raw material components comprise 30 parts of radix sophorae flavescentis, 30 parts of cortex dictamni, 15 parts of radix stemonae, 10 parts of cortex phellodendri, 3 parts of rheum officinale and 6 parts of sargentgloryvine stem.
4. A method for preparing the topical Chinese medicinal composition for treating acne as claimed in claim 1, which is characterized by comprising the following steps:
(1) preparing raw materials according to the raw material component proportion;
(2) soaking radix Sophorae Flavescentis, cortex Dictamni Radicis, radix Stemonae and cortex Phellodendri in water for at least 2 hr, and respectively extracting with water under normal pressure, negative pressure or ultrasonic wave to obtain radix Sophorae Flavescentis extractive solution, cortex Dictamni Radicis extractive solution, radix Stemonae extractive solution and cortex Phellodendri extractive solution;
(3) mixing radix Sophorae Flavescentis extractive solution, cortex Dictamni Radicis extractive solution, radix Stemonae extractive solution and cortex Phellodendri extractive solution, and filtering to remove residue, ash and macromolecular compounds to obtain purified filtrate;
(4) heating the purified filtrate, evaporating and concentrating to obtain a concentrate;
(5) drying the rhubarb and the sargentgloryvine stem in the raw materials to remove water, then crushing, and carrying out ultrafine crushing by using an ultrafine crusher until the particle size is less than or equal to 40 microns to prepare ultrafine mixed powder;
(6) putting the mixed powder into the concentrated solution, and adding a preservative and a humectant to obtain a mixed material; dispersing and homogenizing the mixed materials by adopting a homogenizing emulsifying machine at a stirring speed of 2000-4000 revolutions per minute, and then shearing and refining the mixed materials by adopting a stirring speed of 6000-9000 revolutions per minute to prepare paste so as to obtain the external traditional Chinese medicine composition for treating acne.
5. The method for preparing the external traditional Chinese medicine composition for treating acne according to claim 4, characterized in that in the step (2), when normal pressure extraction, negative pressure extraction or ultrasonic extraction is carried out, the mass ratio of the lightyellow sophora root, the dittany bark, the sessile stemona root or the amur corktree bark to water is 1 (8-10), 2 times of extraction are carried out, and the liquid obtained after the two times of extraction is mixed to be used as lightyellow sophora root extracting solution, dittany bark extracting solution, sessile stemona root extracting solution and amur corktree bark extracting solution; wherein, the normal pressure extraction adopts traditional Chinese medicine normal pressure reflux extraction equipment, and the extraction time is 1.5-2.0 hours each time; the negative pressure extraction adopts traditional Chinese medicine vacuum extraction equipment, the extraction time is 1.0-1.5 hours each time, and the working pressure during extraction is-0.06-0.08 MPa; traditional Chinese medicine ultrasonic extraction equipment is adopted for ultrasonic extraction, and the extraction time is 25-35 minutes each time.
6. The method for preparing a topical Chinese medicinal composition for the treatment of acne as claimed in claim 4, wherein in step (2), radix Sophorae Flavescentis, cortex Dictamni Radicis, radix Stemonae and cortex Phellodendri are in tablet form when extracting under normal pressure or negative pressure; when ultrasonic extraction is carried out, radix Sophorae Flavescentis, cortex Dictamni Radicis, radix Stemonae and cortex Phellodendri are firstly pulverized to particle size of below 5 mm.
7. The method for preparing a topical Chinese medicinal composition for the treatment of acne according to claim 4, characterized in that in step (3), the filtration is performed by rough filtration with centrifugal filter, ultrafiltration with ceramic membrane and nanofiltration with hollow fiber column; the molecular weight of the substance in the obtained purified filtrate is less than 10000.
8. The method for preparing a topical Chinese medicinal composition for the treatment of acne according to claim 4, characterized in that in step (4), the evaporation concentration is performed by using a steam boiler, a single-effect evaporator or a multiple-effect evaporator, and the mass of the obtained concentrate is 20-25% of the total mass of the purified filtrate.
9. The method for preparing a topical Chinese medicinal composition for treating acne as claimed in claim 4, wherein in step (5), the dried material is pulverized, then the part below 60 mesh is sieved to obtain a primary powder, the sieved material is further pulverized to below 80 mesh to obtain a secondary powder, and the primary powder and the secondary powder are mixed and subjected to micronization.
10. The method for preparing a topical Chinese medicinal composition for the treatment of acne as claimed in claim 4, wherein in step (6), the antiseptic is ethylparaben, and the addition amount is less than 0.02% of the total mass of the mixture; the humectant is sodium carboxymethylcellulose, and the addition amount of the humectant is 2-3% of the total mass of the mixed material.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1091647A (en) * | 1993-03-03 | 1994-09-07 | 武汉市中西医结合医院 | Antipyretic and itching-stopping prescription |
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2020
- 2020-03-25 CN CN202010217154.1A patent/CN111195334A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1091647A (en) * | 1993-03-03 | 1994-09-07 | 武汉市中西医结合医院 | Antipyretic and itching-stopping prescription |
Non-Patent Citations (3)
| Title |
|---|
| 刘莹: "《中医中药养生一对一》", 30 June 2016, 上海科学普及出版社 * |
| 卢晓: "愈痤饮配合面膜及外擦消痤酊治疗重度痤疮60例", 《陕西中医》 * |
| 李敏: "《图解秘方大全》", 31 January 2018, 中医古籍出版社 * |
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