CN111195259A - Preparation method of strontium chloride and D-panthenol composite preparation and anti-allergy restoration application thereof - Google Patents
Preparation method of strontium chloride and D-panthenol composite preparation and anti-allergy restoration application thereof Download PDFInfo
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- CN111195259A CN111195259A CN201811364520.5A CN201811364520A CN111195259A CN 111195259 A CN111195259 A CN 111195259A CN 201811364520 A CN201811364520 A CN 201811364520A CN 111195259 A CN111195259 A CN 111195259A
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- panthenol
- strontium chloride
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- 229910001631 strontium chloride Inorganic materials 0.000 title claims abstract description 49
- AHBGXTDRMVNFER-UHFFFAOYSA-L strontium dichloride Chemical compound [Cl-].[Cl-].[Sr+2] AHBGXTDRMVNFER-UHFFFAOYSA-L 0.000 title claims abstract description 49
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 title claims abstract description 40
- 239000011703 D-panthenol Substances 0.000 title claims abstract description 38
- 235000004866 D-panthenol Nutrition 0.000 title claims abstract description 38
- 229960003949 dexpanthenol Drugs 0.000 title claims abstract description 38
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- 230000003266 anti-allergic effect Effects 0.000 title claims abstract description 17
- 239000002131 composite material Substances 0.000 title claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 230000001804 emulsifying effect Effects 0.000 claims abstract description 15
- 229940015975 1,2-hexanediol Drugs 0.000 claims abstract description 13
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000002253 acid Substances 0.000 claims abstract description 12
- 239000008367 deionised water Substances 0.000 claims abstract description 12
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 12
- 239000007864 aqueous solution Substances 0.000 claims abstract description 9
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 claims abstract description 8
- 238000003756 stirring Methods 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 238000007599 discharging Methods 0.000 claims abstract description 4
- 230000001954 sterilising effect Effects 0.000 claims abstract description 4
- 238000005086 pumping Methods 0.000 claims abstract description 3
- 239000000126 substance Substances 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 6
- 230000008439 repair process Effects 0.000 abstract description 6
- 230000002195 synergetic effect Effects 0.000 abstract description 5
- 238000013329 compounding Methods 0.000 abstract description 4
- 239000003814 drug Substances 0.000 abstract description 4
- 229940079593 drug Drugs 0.000 abstract description 4
- 230000008569 process Effects 0.000 abstract description 4
- 230000037307 sensitive skin Effects 0.000 abstract description 4
- 238000009472 formulation Methods 0.000 abstract description 3
- 239000000203 mixture Substances 0.000 abstract description 3
- 238000003889 chemical engineering Methods 0.000 abstract description 2
- 230000000694 effects Effects 0.000 description 13
- 238000012360 testing method Methods 0.000 description 9
- 239000000047 product Substances 0.000 description 8
- 239000002537 cosmetic Substances 0.000 description 5
- -1 strontium chloride-panthenol Chemical compound 0.000 description 5
- 206010015150 Erythema Diseases 0.000 description 4
- 231100000321 erythema Toxicity 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 230000035945 sensitivity Effects 0.000 description 4
- 206010012442 Dermatitis contact Diseases 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 208000010247 contact dermatitis Diseases 0.000 description 3
- 210000000981 epithelium Anatomy 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 229910001427 strontium ion Inorganic materials 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 201000004624 Dermatitis Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 239000013566 allergen Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000008591 skin barrier function Effects 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 229940034610 toothpaste Drugs 0.000 description 2
- 239000000606 toothpaste Substances 0.000 description 2
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- 229940090898 Desensitizer Drugs 0.000 description 1
- 206010018276 Gingival bleeding Diseases 0.000 description 1
- 208000034619 Gingival inflammation Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000004257 Potassium Channel Human genes 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010040844 Skin exfoliation Diseases 0.000 description 1
- 208000028990 Skin injury Diseases 0.000 description 1
- 206010040914 Skin reaction Diseases 0.000 description 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
- 229930003571 Vitamin B5 Natural products 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 description 1
- 229960002079 calcium pantothenate Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- 230000035618 desquamation Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 238000005562 fading Methods 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000010220 ion permeability Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- RGUVUPQQFXCJFC-UHFFFAOYSA-N n-hydroxyoctanamide Chemical compound CCCCCCCC(=O)NO RGUVUPQQFXCJFC-UHFFFAOYSA-N 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 108020001213 potassium channel Proteins 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000035483 skin reaction Effects 0.000 description 1
- 231100000430 skin reaction Toxicity 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- PWYYWQHXAPXYMF-UHFFFAOYSA-N strontium(2+) Chemical compound [Sr+2] PWYYWQHXAPXYMF-UHFFFAOYSA-N 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 235000009492 vitamin B5 Nutrition 0.000 description 1
- 239000011675 vitamin B5 Substances 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a preparation method of a strontium chloride and D-panthenol composite preparation and an application of the strontium chloride and D-panthenol composite preparation in anti-allergy repair, and belongs to the industries of medicines, chemical engineering and personal care products. A base formulation comprising the following components: 50-80 parts of deionized water, 1-5 parts of strontium chloride, 2-10 parts of D-panthenol, 0.1-1 part of caprylyl hydroximic acid and 0.1-1 part of 1, 2-hexanediol. The preparation method comprises the following steps: A. preparing raw materials: B. sterilizing; C. preparing a D-panthenol-like aqueous solution; D. preparing strontium chloride aqueous solution; E. pumping the strontium chloride aqueous solution into an emulsifying pot, and uniformly stirring; F. adding 0.1-1 part of caprylyl hydroximic acid and 0.1-1 part of 1, 2-hexanediol into an emulsifying pot, uniformly stirring, inspecting a composite physicochemical index, and discharging. The compounding of the strontium chloride and the D-panthenol can achieve a higher synergistic effect, is pleasant to consumers of sensitive skin in the using process, and can fully exert the functions of the strontium chloride and the D-panthenol.
Description
Technical Field
The invention relates to a composite preparation, in particular to a preparation method of a strontium chloride and D-panthenol composite preparation and an anti-allergy restoration application thereof, belonging to the industries of medicines, chemical engineering and personal care products.
Background
When the cosmetic is improperly used, phenomena such as skin allergy, pruritus, desquamation, red swelling, red blood streak and the like can be caused. The hygiene department has shown statistics in 2003 and 2004 that contact dermatitis is the most common of the six major cosmetic skin diseases, and the incidence rates of the contact dermatitis account for 82.6% and 93.3% of the total incidence rate of the cosmetic skin. Common allergens of cosmetic contact dermatitis are mainly as follows: 30 to 40 percent of preservative, 20 to 30 percent of essence and spice, 15 to 20 percent of surfactant, sun-screening agent, antioxidant, antibacterial agent and the like, which are all common additives in cosmetics. In addition, in order to pursue benefits, the skin of part of people is increasingly poor due to illegal addition, and meanwhile, the skin is frequently exposed to the environment of ultraviolet rays, microorganisms and particles, so that the sensitivity of the skin is increasingly worsened, and the skin sensitivity is also increasingly paid more attention by people.
There are many ways to prevent skin allergy, and the main categories are roughly divided; the major categories of the application of anti-histamine substances, the removal of free radicals, the inhibition of allergic factors and the increase of skin barrier function are far away from allergens.
In the patent CN 1864661A, a highly effective stain-removing whitening toothpaste and its manufacturing method, it is mentioned that strontium chloride is used as a desensitizer, which can reduce the pain of dentin during sour, cold, hot, sweet stimulation, tooth brushing and biting, and has the effects of desensitizing and easing pain; d-panthenol is an anti-inflammatory repairing agent, and mainly has the effects of preventing gingival inflammation and bleeding, enhancing periodontal tissue regeneration and making teeth firm and bright and white. However, patent CN 1864661A is only applied to the toothpaste industry, and strontium chloride and D-panthenol only play an auxiliary effect in patent CN 1864661A. The strontium ion has tranquilizing and antiallergic effects on skin, and D-panthenol can repair epithelial tissue, relieve inflammation, and repair skin barrier. The invention discloses a better effect of an anti-allergy test of skin after the preparation is compounded and combined by strontium chloride and D-panthenol.
Disclosure of Invention
The invention aims to provide a preparation method of a strontium chloride and D-panthenol composite preparation and an anti-allergy repair application thereof, so as to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme:
the scheme is as follows:
the invention relates to a preparation method of a strontium chloride and D-panthenol composite preparation and a basic formula of anti-allergy restoration application thereof, wherein the preparation method comprises the following components in parts by weight: 50-80 parts of deionized water, 1-5 parts of strontium chloride, 2-10 parts of D-panthenol, 0.1-1 part of caprylyl hydroximic acid and 0.1-1 part of 1, 2-hexanediol
The preparation method of the strontium chloride-panthenol composite preparation comprises the following steps:
A. preparing raw materials according to the following components by weight:
50-80 parts of deionized water, 1-5 parts of strontium chloride, 2-10 parts of D-panthenol, 0.1-1 part of caprylyl hydroximic acid and 0.1-1 part of 1, 2-hexanediol;
B. adding 50-80 parts of deionized water into an emulsifying pot, heating to 85-90 ℃, keeping the temperature for 20min for sterilization treatment, preparing sterilized water, and cooling to room temperature for later use;
C. adding 2-10 parts of D-panthenol into an emulsifying pot, adding 30-40 parts of prepared sterilized water, vacuumizing to-0.1 MPa, and homogenizing at 4000rpm for 5min to obtain a D-panthenol-like aqueous solution;
D. adding 1-5 parts of strontium chloride into a water kettle, adding 30-40 parts of prepared sterilized water, keeping the temperature at 35-45 ℃, and keeping the temperature for 2H to prepare a strontium chloride aqueous solution;
E. vacuumizing the emulsifying pot to-0.1 MPa, pumping the strontium chloride aqueous solution in the pot into the emulsifying pot by utilizing negative pressure, and uniformly stirring;
F. adding 0.1-1 part of caprylyl hydroximic acid and 0.1-1 part of 1, 2-hexanediol into an emulsifying pot, uniformly stirring, checking to meet physical and chemical indexes, and discharging.
Compared with the prior art, the invention has the beneficial effects that: the complex formulation of the strontium chloride and the D-panthenol can achieve better synergistic effect, is not only pleasant to consumer groups of sensitive skin in the using process, but also a complex formulation capable of fully playing the role of the strontium chloride and the D-panthenol, not only acts on the surface of the skin of a human body, but also can ensure that the strontium chloride and the D-panthenol do not harm the human body after being absorbed by the skin. The invention can be directly applied to smearing, can also be used as a raw material additive in the industries of medicines, chemical industry and personal care products, and has the advantages of simple preparation method, short production period, simple prescription and suitability for people.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The anti-allergy components in the current market can be divided into 2 types: the anti-allergic Chinese herbal medicine components and the chemically synthesized anti-allergic components are high in anti-allergic requirement adding amount, the problems of precipitation, color difference and the like easily occur, the chemically synthesized anti-allergic components are more in variety, excellent in effect and high in price, and most of the chemically synthesized anti-allergic components are used for inhibiting the secretion of inflammatory factors. The invention develops research from epithelial tissues and subcutaneous tissues, has a protective effect on skin through strontium ions, can reduce the sensitivity of the skin, reduces the release of potassium ion channels of the human body by acting on the human body, can supplement the strontium ions in the body along with blood circulation after being absorbed by the skin, and has the effect of a health-care product; d-panthenol used as the precursor of vitamin B5 can not only moisturize and repair epithelial tissues, but also can be converted into nutrients in vivo after being absorbed by skin in a small amount, so that the immunity of a human body is improved, and the effect of protecting the skin and cell mucosa is achieved. The compounding of the strontium chloride and the D-panthenol can achieve a higher synergistic effect, is not only pleasant to consumer groups of sensitive skin in the using process, but also a compound preparation capable of fully playing the role of the strontium chloride, not only acts on the surface of the skin of a human body, and can ensure that the strontium chloride does not cause harm to the human body after being absorbed by the skin. The invention can be used for direct smearing and also can be used as a raw material additive in the industries of medicines, chemical industry and personal care products, and has the advantages of simple preparation method, short production period, simple prescription and wide applicable population.
The specific implementation mode is as follows:
example 1 deionized water 50-80 parts, strontium chloride 1 part, D-panthenol 2 parts, caprylyl hydroxamic acid 0.1-1 part, 1, 2 hexanediol 0.1-1 part;
example 2 deionized water 50-80 parts, strontium chloride 2 parts, D-panthenol 4 parts, caprylyl hydroxamic acid 0.1-1 part, 1, 2 hexanediol 0.1-1 part;
example 3 deionized water 50-80 parts, strontium chloride 3 parts, D-panthenol 8 parts, caprylyl hydroxamic acid 0.1-1 parts, 1, 2 hexanediol 0.1-1 parts;
example 4 deionized water 50-80 parts, strontium chloride 5 parts, caprylyl hydroxamic acid 0.1-1 part, 1, 2 hexanediol 0.1-1 part
Examples 1-4 were all prepared by the following procedure
Adding deionized water into an emulsifying pot, heating to 85 deg.C, keeping the temperature for 20min, sterilizing, cooling to room temperature, adding D-panthenol, vacuumizing to-0.1 MPa, homogenizing at 4000rpm for 5min, adding strontium chloride into the emulsifying pot, stirring, adding 1, 2-hexanediol octanoyl hydroxamic acid into the emulsifying pot, stirring, inspecting, and discharging
The test method specifically comprises the following steps:
a total of 20 subjects (5 per group) were attached to their skin for 24 hours with a filter containing 100. mu.L of the test solution at the center, and then the filter was removed to evaluate the degree of skin reaction (the specific groups and the test sensitivity sources are shown below)
TABLE 1
The test evaluation tag annotation is shown below
| Marking | Grade | Criterion of evaluation |
| + | 1 | Slight erythema, either punctate or diffuse |
| ++ | 2 | Moderate uniform erythema |
| +++ | 3 | Intense erythema with edema |
| ++++ | 4 | Intense erythema with edema and vesicles |
| - | 0 | Has no irritation or reaction |
TABLE 2
The test results are shown in the following table
Results of clinical skin test in group A
TABLE 3
Results of clinical skin test in group B
TABLE 4
Results of clinical skin test in group C
TABLE 5
Clinical skin test results in group D
TABLE 6
The results show that the results of the group AB are the best, the group C is the next, and the group D has poor effect, which shows that the strontium chloride and the D-panthenol can play a synergistic effect after being compounded, so that the anti-allergy effect is enhanced.
In order to further verify the compounding performance of strontium chloride and D-panthenol, a secondary test is carried out, and the test method is as follows; 45 volunteers aged 18-35 years, 15 men and women, with similar lesions on the facial skin were randomly drawn and divided into blanks using embodiment 1, embodiment 2 and no repair product.
The using method comprises the following steps: after the face is cleaned by clear water, each group of corresponding products is evenly smeared on the face, and is gently massaged until the products are absorbed, the treatment effect is recorded after the products are continuously used twice in the morning and at night every day for 7 days.
And (3) evaluating the curative effect: the efficacy evaluation is carried out by using the condition of red and swollen regression, and the evaluation is respectively marked, effective and ineffective. Wherein significant means that the red and swollen are resolved by 40 percent or more, and the symptoms are relieved; effective means that the red swelling subsides 15% -40%, and the symptom is improved; ineffective means less than 15% regression of the red swelling and no improvement in symptoms.
The specific therapeutic effects are shown in the following table:
TABLE 7
The result shows that the anti-allergy skin injury repairing compound preparation provided by the invention has a remarkable treatment effect. The addition amount of the strontium chloride fed back from the side surface is too high, so that the ion permeability is too fast, and discomfort is caused; the anti-sensitivity performance of the D-panthenol is almost not shown under the reaction of no strontium chloride; however, after the strontium chloride and the D-panthenol are compounded, the fading effect on the red and swollen condition of the skin is remarkable, the performance of the strontium chloride and the D-panthenol are optimal when the strontium chloride and the D-panthenol are compounded according to the embodiment 2, and the compounding of the strontium chloride and the D-panthenol can play a higher synergistic effect, so that the strontium chloride and the D-panthenol are pleasant in the using process of consumer groups of sensitive skin, and the strontium chloride and the D-panthenol are a compounded preparation which can fully exert the functions of the strontium chloride and the D-panthenol, not only act on the surface of the skin of a human body, but also can ensure that the strontium chloride and the D-pant.
Claims (1)
1. The preparation method of the strontium chloride and D-panthenol composite preparation and the anti-allergy restoration application thereof are characterized by comprising the following components in parts by weight:
50-80 parts of deionized water, 1-5 parts of strontium chloride, 2-10 parts of D-panthenol, 0.1-1 part of caprylyl hydroximic acid and 0.1-1 part of 1, 2-hexanediol;
the preparation method comprises the following steps:
A. preparing raw materials according to the following components by weight:
50-80 parts of deionized water, 1-5 parts of strontium chloride, 2-10 parts of D-panthenol, 0.1-1 part of caprylyl hydroximic acid and 0.1-1 part of 1, 2-hexanediol;
B. adding 50-80 parts of deionized water into an emulsifying pot, heating to 85-90 ℃, keeping the temperature for 20min for sterilization treatment, preparing sterilized water, and cooling to room temperature for later use;
C. adding 2-10 parts of D-panthenol into an emulsifying pot, adding 30-40 parts of prepared sterilized water, vacuumizing to-0.1 MPa, and homogenizing at 4000rpm for 5min to obtain a D-panthenol-like aqueous solution;
D. adding 1-5 parts of strontium chloride into a water kettle, adding 30-40 parts of prepared sterilized water, keeping the temperature at 35-45 ℃, and keeping the temperature for 2H to prepare a strontium chloride aqueous solution;
E. vacuumizing the emulsifying pot to-0.1 MPa, pumping the strontium chloride aqueous solution in the pot into the emulsifying pot by utilizing negative pressure, and uniformly stirring;
F. adding 0.1-1 part of caprylyl hydroximic acid and 0.1-1 part of 1, 2-hexanediol into an emulsifying pot, uniformly stirring, checking to meet physical and chemical indexes, and discharging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811364520.5A CN111195259A (en) | 2018-11-16 | 2018-11-16 | Preparation method of strontium chloride and D-panthenol composite preparation and anti-allergy restoration application thereof |
Applications Claiming Priority (1)
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| CN201811364520.5A CN111195259A (en) | 2018-11-16 | 2018-11-16 | Preparation method of strontium chloride and D-panthenol composite preparation and anti-allergy restoration application thereof |
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| CN1175206A (en) * | 1994-12-21 | 1998-03-04 | 科斯梅德姆技术公司 | Formulations and methods for reducing skin irritation |
| GB2425060A (en) * | 2005-03-24 | 2006-10-18 | Santosolve As | Strontium compounds in cosmetics |
| WO2007060381A1 (en) * | 2005-11-24 | 2007-05-31 | Santosolve As | Strontium-containing compositions and their use in methods of cosmetic treatment |
| CN101703456A (en) * | 2009-12-11 | 2010-05-12 | 江西诚志日化有限公司 | Combined chloranthus glaber whitening gelatin with anti-allergic agent and preparation method thereof |
| CN103242391A (en) * | 2012-02-13 | 2013-08-14 | 南京华狮化工有限公司 | Method for preparing strontium glycyrrhetate compound, and product and application thereof |
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| CN1175206A (en) * | 1994-12-21 | 1998-03-04 | 科斯梅德姆技术公司 | Formulations and methods for reducing skin irritation |
| GB2425060A (en) * | 2005-03-24 | 2006-10-18 | Santosolve As | Strontium compounds in cosmetics |
| WO2007060381A1 (en) * | 2005-11-24 | 2007-05-31 | Santosolve As | Strontium-containing compositions and their use in methods of cosmetic treatment |
| CN101703456A (en) * | 2009-12-11 | 2010-05-12 | 江西诚志日化有限公司 | Combined chloranthus glaber whitening gelatin with anti-allergic agent and preparation method thereof |
| CN103242391A (en) * | 2012-02-13 | 2013-08-14 | 南京华狮化工有限公司 | Method for preparing strontium glycyrrhetate compound, and product and application thereof |
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Application publication date: 20200526 |