CN111195228A - Mosquito-repellent composition and preparation method thereof - Google Patents
Mosquito-repellent composition and preparation method thereof Download PDFInfo
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- CN111195228A CN111195228A CN202010210912.7A CN202010210912A CN111195228A CN 111195228 A CN111195228 A CN 111195228A CN 202010210912 A CN202010210912 A CN 202010210912A CN 111195228 A CN111195228 A CN 111195228A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
Abstract
The invention relates to the technical field of daily chemical articles, in particular to a mosquito repellent composition and a preparation method thereof. The mosquito repellent composition at least comprises the following components in parts by weight: 0.5-5 parts of plant extract, 0.01-0.5 part of solubilizer, 0.1-3 parts of essence, 0.005-0.1 part of complexing agent and the balance of solvent to 100 parts. The mosquito repellent composition prepared by the invention adopts natural plant extracts as main components, does not contain chemical insecticides, is green, environment-friendly, safe and nontoxic, can be directly smeared or sprayed on human skin, has good effects of sterilizing, repelling mosquitoes, moistening the skin and the like, has long mosquito repellent retention time, has no side effect on human bodies, and is convenient to use.
Description
Technical Field
The invention relates to the technical field of daily chemical articles, in particular to a mosquito repellent composition and a preparation method thereof.
Background
Mosquito is one of four pests, and is a great hidden danger threatening human health, the struggle between human and human has never been stopped, but the transmission of diseases is still not stopped, especially, in recent years, the concern of people about mosquito bite transmission diseases is further aggravated by a plurality of reports about west nile virus outbreak and tick bite death. Mosquitoes are a serious public health problem in most parts of the world, and it is estimated that about 7 million people are infected with various diseases by mosquitoes every year, and 1 person dies of every 17 people from the diseases infected with mosquitoes. Especially in tropical regions, various infectious diseases are often transmitted to humans by mosquitoes. China is in tropical and subtropical regions, is a large country with 14 hundred million people, and has 60000 towns and 4 hundred million families. In recent years, with the continuous improvement of living standard of substances, people have stronger health consciousness, mosquito bites are prevented, and the concept of keeping away from disease infection makes people have more and more demands on mosquito repellent products and higher requirements.
The products on the market for preventing mosquito bites in China at present can be roughly classified into four types: the first type is mosquito-repellent incense, including traditional mosquito coil incense, electric mosquito-repellent incense and liquid mosquito-repellent incense; the second is aerosol insecticides; the third kind is physical mosquito repelling, such as electric mosquito swatter, mosquito net, etc.; the fourth class is repellents, including natural and synthetic mosquito repellent products in the form of mosquito repellent liquids, mosquito repellent toilet waters, mosquito repellent gels, and the like. Most of the first and second products contain pyrethroid compounds, which have certain toxicity to the environment and human body, and the third product is not suitable for outdoor and sports. The fourth class of repellent has the advantages of safety, high efficiency and convenient use. Natural mosquito repellent products are generally based on plant-derived mosquito repellent products. The main components of plant extract are monoterpene, sesquiterpene, aliphatic compound and aromatic hydrocarbon derivative, and have various biological activities. At present, plant essential oil forms a new field in the aspects of antibiosis, antioxidation, disinsection and the like. Especially, the insecticidal composition has the advantages of safety to people and livestock, delaying of drug resistance of pests, no pollution to living environment and the like aiming at prevention and control of sanitary pests, natural pyrethrin, plant essential oil and other plant-derived insecticidal active substances, and has huge development potential and application value in the field of sanitary insecticidal.
The different plant extracts contain different active substances, the single plant extract has undesirable mosquito repelling effect and short duration, and the invention obtains the mosquito repelling composition with higher mosquito repelling rate and longer duration by compounding the plant extracts.
Disclosure of Invention
In order to solve the technical problems, the invention provides a mosquito repellent composition in a first aspect, which at least comprises the following components in parts by weight: 0.5-5 parts of plant extract, 0.01-0.5 part of solubilizer, 0.1-3 parts of essence, 0.005-0.1 part of complexing agent and the balance of solvent to 100 parts.
As a preferred embodiment of the present invention, the plant extract is at least one selected from the group consisting of eucalyptus citriodora leaf oil, cnidium monnieri essential oil, oregano oil, eucommia ulmoides seed extract, lantana camara extract, geranium extract, marigold extract, coptidis deltoidea extract, borneol, menthol, honeysuckle extract, zedoary extract, corydalis tuber extract, stemona root extract, citronella extract, salvia miltiorrhiza extract and astragalus membranaceus extract.
In a preferred embodiment of the present invention, the plant extract at least comprises at least one of borneol, menthol, eucalyptus citriodora leaf oil and citronella extract.
As a preferable technical scheme of the invention, the weight ratio of the borneol, the menthol, the eucalyptus citriodora leaf oil and the citronella extract is (1-5): (1-5): 1: (3-8).
As a preferable technical scheme of the invention, the weight ratio of the borneol, the menthol, the eucalyptus citriodora leaf oil and the citronella extract is (2-3): (1.5-2.5): 1: (4-6).
In a preferred embodiment of the present invention, the solubilizer is a nonionic solubilizer.
As a preferable technical scheme of the invention, the weight ratio of the solubilizer to the essence is 1: (2-7).
In a preferred embodiment of the present invention, the complexing agent is at least one selected from the group consisting of sodium tripolyphosphate, sodium polyphosphate, sodium hexametaphosphate, sodium pyrophosphate, ethylenediaminetetraacetic acid, nitrilotriacetic acid, diethylenetriaminepentaacetic acid, N-hydroxyethylethanamine triacetic acid, ethylene glycol-bis- (B-aminoethyl ether) -N, N-tetraacetic acid, disodium ethylenediaminetetraacetate, gluconic acid, and polyacrylic acid.
In a preferred embodiment of the present invention, the solvent is alcohol and/or water.
The second aspect of the invention provides a preparation method of the mosquito repellent composition, which comprises the following steps: mixing solubilizer, essence and solvent, and stirring to dissolve completely; then adding the plant extract and the complexing agent, continuously stirring until the mixture is uniformly mixed, and discharging to obtain the plant extract-complexing agent.
Has the advantages that: the mosquito repellent composition prepared by the invention adopts natural plant extracts as main components, does not contain chemical insecticides, is green, environment-friendly, safe and nontoxic, can be directly smeared or sprayed on human skin, has good effects of sterilizing, repelling mosquitoes, moistening the skin and the like, has long mosquito repellent retention time, has no side effect on human bodies, and is convenient to use.
Detailed Description
The disclosure may be understood more readily by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.
The term "prepared from …" as used herein is synonymous with "comprising". The terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.
The conjunction "consisting of …" excludes any unspecified elements, steps or components. If used in a claim, the phrase is intended to claim as closed, meaning that it does not contain materials other than those described, except for the conventional impurities associated therewith. When the phrase "consisting of …" appears in a clause of the subject matter of the claims rather than immediately after the subject matter, it defines only the elements described in the clause; other elements are not excluded from the claims as a whole.
When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when a range of "1 to 5" is disclosed, the described range should be interpreted to include the ranges "1 to 4", "1 to 3", "1 to 2 and 4 to 5", "1 to 3 and 5", and the like. When a range of values is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.
The singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. "optional" or "any" means that the subsequently described event or events may or may not occur, and that the description includes instances where the event occurs and instances where it does not.
Approximating language, as used herein throughout the specification and claims, is intended to modify a quantity, such that the invention is not limited to the specific quantity, but includes portions that are literally received for modification without substantial change in the basic function to which the invention is related. Accordingly, the use of "about" to modify a numerical value means that the invention is not limited to the precise value. In some instances, the approximating language may correspond to the precision of an instrument for measuring the value. In the present description and claims, range limitations may be combined and/or interchanged, including all sub-ranges contained therein if not otherwise stated.
In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the stated number clearly indicates that the singular form is intended.
In order to solve the technical problems, the invention provides a mosquito repellent composition in a first aspect, which at least comprises the following components in parts by weight: 0.5-5 parts of plant extract, 0.01-0.5 part of solubilizer, 0.1-3 parts of essence, 0.005-0.1 part of complexing agent and the balance of solvent to 100 parts.
Preferably, the mosquito repellent composition at least comprises the following components in parts by weight: 0.5-2 parts of plant extract, 0.1-0.3 part of solubilizer, 0.5-1.5 parts of essence, 0.01-0.05 part of complexing agent and the balance of solvent to 100 parts.
More preferably, the mosquito repellent composition at least comprises the following components in parts by weight: 1.08 parts of plant extract, 0.2 parts of solubilizer, 1 part of essence, 0.02 part of complexing agent and 100 parts of solvent complement.
Plant extracts
Plant extracts (Plant extracts) refer to substances extracted or processed from plants (whole or a part of plants) by using a suitable solvent or method, and can be used in the pharmaceutical industry, the food industry, the health industry, the beauty industry and other industries.
The plant extract is a product formed by taking plants as raw materials, directionally obtaining and concentrating one or more active ingredients in the plants through a physical and chemical extraction and separation process according to the requirements of the application of an extracted final product, and not changing the structures of the active ingredients. According to different components of the extracted plants, glycoside, acid, polyphenol, polysaccharide, terpenoid, flavone, alkaloid and the like are formed; according to different properties, the plant oil can be divided into vegetable oil, extract, powder, crystalline lens and the like.
In the present invention, the plant extract is at least one selected from the group consisting of eucalyptus citriodora leaf oil, cnidium monnieri essential oil, oregano oil, eucommia ulmoides seed extract, prunus mume flower extract, geranium extract, marigold extract, coptidis rhizoma extract, borneol, menthol, honeysuckle extract, curcuma zedoary extract, rhizoma corydalis extract, stemona root extract, citronella extract, salvia miltiorrhiza extract and astragalus membranaceus extract.
Preferably, the plant extract at least comprises at least one of borneol, menthol, eucalyptus citriodora leaf oil and citronella extract.
Borneol (borneol)
Borneolum, named as Borneolum, pericarpium Citri Tangerinae, folium Artemisiae Argyi, Borneolum Syntheticum, Serissa, Borneolum Syntheticum, and Borneolum Syntheticum, is prepared from stems and leaves of blumea balsamifera of Compositae or branches and leaves of Cinnamomum camphora of Lauraceae by steam distillation and recrystallization. Also can be obtained by a series of chemical processes using turpentine. It can be used for treating block pattern of coma, conjunctival congestion with swelling and pain, pharyngitis, aphtha, sore and ulcer with swelling and pain, and unhealed ulcer.
Ben Cao Jing Shu (the book of materia Medica Prime and Dredging): it is contraindicated for patients with apoplexy due to qi and blood deficiency, but without exogenous pathogenic wind; the infantile vomiting and diarrhea with convulsion is slow spleen wind, the acute convulsion is due to excess heat, and the slow convulsion is due to deficiency-cold; herbs should not be used for dim eyes due to deficiency of liver and kidney. "
In the present invention, the source of the borneol is not particularly limited, and the borneol can be purchased from Gean Shengda flavor oil Co.
Menthol crystal
Menthol is a saturated cyclic alcohol obtained from peppermint oil. Also named as menthol and menthol. Easy combustion, full combustion and no smoke in combustion. The product is colorless acicular or prismatic crystal or white crystalline powder; the mint has special fragrance of mint, and the taste is cool after the mint is scorched at the beginning; the ethanol solution shows a neutral reaction. The product is very soluble in ethanol, chloroform, diethyl ether, liquid paraffin or volatile oil, and very slightly soluble in water.
Menthol is a chemical agent extracted from the leaves and stems of peppermint, is a white crystal with the molecular formula of C10H20O, and is the main component of peppermint and peppermint essential oils. India is the major natural mint producing country in the world. Menthol and racemic menthol can be used as flavoring agents for toothpaste, perfume, beverage, candy, etc. It can be used as irritant in medicine, and has effects in refreshing and relieving itching; can be taken orally as a wind-expelling medicine for treating headache, inflammation of nose, pharynx, larynx, etc.; the esters thereof are useful in perfumery and in pharmaceuticals.
In the present invention, the source of the menthol is not particularly limited, and it is commercially available from Jian Shengda flavor oil Co.
Lemon eucalyptus oil
The eucalyptus citriodora leaf oil is a plant essential oil extracted from the leaves of the eucalyptus citriodora trees and has the effects of resisting bacteria and killing insects.
In the present invention, the source of the eucalyptus citriodora leaf oil is not particularly limited, and is commercially available from Xiamen, Li Ltd.
Cymbopogon citratus extract
The Cymbopogon nardus extract is extracted from Cymbopogon nardus (Cymbopogon nardus) belonging to genus Cymbopogon of family Gramineae. Although this essential oil has long been recognized as an insect repellent (particularly effective against malaria-bearing mosquitoes). It also has great benefits for refreshing the brain, purifying the room, softening the skin; it can also be used for cleaning oily skin and sweaty feet. Essential oils are very volatile and evaporate quickly upon contact with air, and for this reason they must be stored in sealable bottles and capped quickly once the bottle is opened for use. A few drops of citronella extract are dripped into hot water for soaking feet, so that the aim of activating blood and meridians can be fulfilled, and the effect of removing beriberi and foot odor can be achieved.
In the present invention, the source of the citronella extract is not particularly limited, and the citronella extract is commercially available from Guangzhou tide chemical engineering Co.
In the invention, the weight ratio of the borneol, the menthol, the eucalyptus citriodora leaf oil and the citronella extract is (1-5): (1-5): 1: (3-8).
Preferably, the weight ratio of the borneol, the menthol, the eucalyptus citriodora leaf oil and the citronella extract is (2-3): (1.5-2.5): 1: (4-6).
More preferably, the weight ratio of the borneol, the menthol, the eucalyptus citriodora leaf oil and the citronella extract is 2.8: 2: 1: 5.
the mosquito repellent composition has certain fragrance and mosquito repellent activity, can prevent the bite of mosquitoes for a long time, effectively prevents mosquito-transmitted diseases, and has certain water retention and moistening effects and cooling effects on skin after being applied. At present, the most used mosquito repelling modes are burning mosquito incense and spraying spray type chemical insecticide, and the mosquito incense and the chemical insecticide not only pollute the environment, but also damage the health of human bodies when killing mosquitoes; the mosquito repelling composition prepared by the invention belongs to a plant essential oil type mosquito repelling composition, and not only can effectively repel mosquitoes, but also reduces the pollution to the environment and the harm to the human health.
Solubilizer
The solubilizer means a surfactant having solubilizing ability. Solubilization refers to a process of increasing the solubility of a poorly soluble drug in a solvent and forming a solution under the action of a surfactant.
In the invention, the solubilizer is a non-ionic solubilizer.
Preferably, the solubilizer is PEG-40 hydrogenated castor oil.
In the present invention, the source of the PEG-40 hydrogenated castor oil is not particularly limited, and it is commercially available from Xiamen, Li Ltd.
Essence
In the personal care product, the essence mainly plays a role of endowing the product with fragrance, and has aesthetic value. Besides perfuming, the essence has other useful functions. The human smell sense organ receives the smell of the essence, and the sense organ is closely related to the part of the brain responsible for the emotion, so the essence has great influence on the human emotion.
In the present invention, the essence is not particularly limited, and is available under the trade name FH 21159 from fenghao essence and flavor ltd.
In the invention, the weight ratio of the solubilizer to the essence is 1: (2-7).
Preferably, the weight ratio of the solubilizer to the essence is 1: (2-7).
More preferably, the weight ratio of the solubilizer to the essence is 1: 5.
during the development process, the inventors find that the addition of hydrogenated castor oil can improve the solubility of the essence in the composition, and further improve the stability of the composition, especially when the weight ratio of the hydrogenated castor oil to the essence is 1: when 5, the shape and stability of the composition are the best.
Complexing agents
The metal atom or ion reacts with a ligand having two or more coordinating atoms to form a complex having a cyclic structure, which is called a chelate. The ligand species capable of forming chelates is called chelating agents, and also acts as complexing agents. Also known as chelating ligands (chelating groups), chelating groups (chelating groups) or polydentate ligands (ligands). The ligand has two or more coordinating atoms and forms a chelate ring with a central atom (or ion). The chelating agent has higher stability than non-chelating coordination compound with similar composition and structure due to the ring formation of the chelating agent. Chelating agents are mostly organic ligands. The chelating agents found to date are up to fourteen teeth. The coordinating atoms in the chelating agent are most commonly oxygen and nitrogen, followed by sulfur, and also phosphorus, arsenic, etc. This class of compounds is described by "chelators" because the molecular structure is much like the two large "clamps" of a "crab" that clamp a metal atom or ion.
In the invention, the complexing agent is at least one selected from sodium tripolyphosphate, sodium polyphosphate, sodium hexametaphosphate, sodium pyrophosphate, ethylene diamine tetraacetic acid, nitrilotriacetic acid, diethylenetriamine pentaacetic acid, N-hydroxyethyl ethylamine triacetic acid, ethylene glycol-bis- (B-aminoethyl ether) -N, N-tetraacetic acid, ethylene diamine tetraacetic acid disodium, gluconic acid and polyacrylic acid.
Preferably, the complexing agent is disodium ethylenediaminetetraacetate.
In the present invention, the source of the disodium edetate is not particularly limited, and it is commercially available from Xiamen, Li, Inc.
Solvent(s)
In the present invention, the solvent is alcohol and/or water.
Preferably, the solvent is ethanol and water.
Preferably, the weight ratio of ethanol to water is 1: (1.5-3.5).
More preferably, the weight ratio of ethanol to water is 1: 2.1.
the addition of the essence has a certain influence on the volatilization speed of the eucalyptus citriodora oil, so that the influence of the essence is considered when determining the adding amount of the alcohol. During the development process, the inventor finds that the addition of the alcohol is used for adjusting the volatilization speed of the eucalyptus citriodora leaf oil, and the volatilization speed of the eucalyptus citriodora leaf oil is actually influenced by the content of each component in the product, but is mainly influenced by the content of the alcohol and the water. Through a large number of researches, when the weight percentage of each component is within the range determined by the invention, the prepared product has relatively stable and lasting mosquito repellent effect.
The second aspect of the invention provides a preparation method of the mosquito repellent composition, which comprises the following steps: mixing solubilizer, essence and solvent, and stirring to dissolve completely; then adding the plant extract and the complexing agent, continuously stirring until the mixture is uniformly mixed, and discharging to obtain the plant extract-complexing agent.
The present invention will be specifically described below by way of examples. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention.
In addition, the starting materials used are all commercially available, unless otherwise specified.
Examples
Example 1
Embodiment 1 provides a mosquito repellent composition, comprising the following components in parts by weight: 1.08 parts of plant extract, 0.2 parts of solubilizer, 1 part of essence, 0.02 part of complexing agent and 100 parts of solvent; the plant extracts are borneol, menthol, eucalyptus citriodora leaf oil and citronella extract, and the weight ratio is 2.8: 2: 1: 5; the solubilizer is hydrogenated castor oil; the complexing agent is disodium ethylene diamine tetraacetate; the solvent is ethanol and water, and the weight ratio is 1: 2.1.
the preparation method of the mosquito repellent composition comprises the following steps: mixing solubilizer, essence and solvent, and stirring to dissolve completely; then adding the plant extract and the complexing agent, continuously stirring until the mixture is uniformly mixed, and discharging to obtain the plant extract-complexing agent.
Example 2
The embodiment 2 is different from the embodiment 1 in that the mosquito repellent composition comprises the following components in parts by weight: 0.5 part of plant extract, 0.01 part of solubilizer, 0.1 part of essence, 0.005 part of complexing agent and 100 parts of solvent complement.
Example 3
The embodiment 3 is different from the embodiment 1 in that the mosquito repellent composition comprises the following components in parts by weight: 5 parts of plant extract, 0.5 part of solubilizer, 3 parts of essence, 0.1 part of complexing agent and the balance of solvent to 100 parts.
Example 4
The embodiment 4 is different from the embodiment 1 in that the mosquito repellent composition comprises the following components in parts by weight: 0.5 part of plant extract, 0.1 part of solubilizer, 0.5 part of essence, 0.01 part of complexing agent and 100 parts of solvent complement.
Example 5
The embodiment 5 is different from the embodiment 1 in that the mosquito repellent composition comprises the following components in parts by weight: 2 parts of plant extract, 0.3 part of solubilizer, 1.5 parts of essence, 0.05 part of complexing agent and the balance of solvent to 100 parts.
Example 6
Example 6 differs from example 1 in that eucalyptus citriodora oil is not included.
Example 7
Example 7 differs from example 1 in that citronella extract is not included.
Example 8
Example 8 differs from example 1 in that ice flakes are not included.
Example 9
Example 9 differs from example 1 in that menthol is not included.
Performance testing
Mosquito repelling aging test experiment
The test was carried out with reference to the standard GB/T13917.9-2009 insecticide registration-use hygienic insecticide indoor efficacy test and evaluation part 9. The blood type is qualified in 9 attacking forcesThe skin area of 5cm × 5cm was drawn on the back of each hand of type A volunteers, wherein one hand was blank control and the other hand was applied with the mosquito repellent composition prepared in examples 1-9 of the present invention at a dose of 1.5 μ l/cm24cm × 4cm of skin was exposed, and the rest was masked. And (3) after the mosquito repellent liquid is coated for 2 hours, stretching the hands into a mosquito cage for 2min, observing whether the mosquitoes suck blood before, testing once every hour, recording the stopping and falling conditions of the mosquitoes, and judging that the mosquito repellent liquid is invalid as long as 1 mosquito sucks blood before.
TABLE 1 test results of effective mosquito repelling time of mosquito repelling compositions prepared in examples 1-9
The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.
Claims (10)
1. The mosquito repellent composition is characterized by at least comprising the following components in parts by weight: 0.5-5 parts of plant extract, 0.01-0.5 part of solubilizer, 0.1-3 parts of essence, 0.005-0.1 part of complexing agent and the balance of solvent to 100 parts.
2. A mosquito repellent composition according to claim 1, wherein the plant extract is selected from at least one of eucalyptus citriodora leaf oil, cnidium monnieri essential oil, oregano oil, eucommia ulmoides seed extract, lantana camara extract, geranium extract, marigold extract, coptidis rhizome extract, borneol, menthol, honeysuckle extract, curcuma zedoary extract, corydalis tuber extract, stemona root extract, citronella extract, salvia miltiorrhiza extract and astragalus membranaceus extract.
3. A mosquito repellent composition according to claim 2, wherein said plant extract comprises at least one of borneol, menthol, eucalyptus citriodora leaf oil and citronella extract.
4. A mosquito repellent composition according to claim 3, wherein the weight ratio of the borneol, the menthol, the eucalyptus citriodora leaf oil and the citronella extract is (1-5): (1-5): 1: (3-8).
5. A mosquito repellent composition according to claim 4, wherein the weight ratio of the borneol, the menthol, the eucalyptus citriodora leaf oil and the citronella extract is (2-3): (1.5-2.5): 1: (4-6).
6. A mosquito repellent composition according to claim 5, wherein the solubilizer is a non-ionic solubilizer.
7. A mosquito repellent composition according to claim 1, wherein the weight ratio of the solubilizer to the essence is 1: (2-7).
8. A mosquito repellent composition according to claim 1, wherein the complexing agent is selected from at least one of sodium tripolyphosphate, sodium polyphosphate, sodium hexametaphosphate, sodium pyrophosphate, ethylenediaminetetraacetic acid, nitrilotriacetic acid, diethylenetriaminepentaacetic acid, N-hydroxyethylethanamine triacetic acid, ethylene glycol-bis- (B-aminoethylether) -N, N-tetraacetic acid, disodium ethylenediaminetetraacetate, gluconic acid and polyacrylic acid.
9. A mosquito repellent composition according to claim 1, wherein the solvent is alcohol and/or water.
10. A method of preparing a mosquito repellent composition according to any one of claims 1 to 9, comprising the steps of: mixing solubilizer, essence and solvent, and stirring to dissolve completely; then adding the plant extract and the complexing agent, continuously stirring until the mixture is uniformly mixed, and discharging to obtain the plant extract-complexing agent.
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| CN202010210912.7A CN111195228A (en) | 2020-03-24 | 2020-03-24 | Mosquito-repellent composition and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111821331A (en) * | 2020-07-21 | 2020-10-27 | 昆明医科大学 | External gel for repelling mosquitoes, relieving itching and diminishing swelling and preparation method thereof |
| CN112704651A (en) * | 2021-01-12 | 2021-04-27 | 四川嗨葆生物科技有限公司 | Mosquito repellent and preparation method thereof |
| CN114938804A (en) * | 2022-06-15 | 2022-08-26 | 王泽君 | Menthol-based mosquito repellent liquid composition and preparation method thereof |
-
2020
- 2020-03-24 CN CN202010210912.7A patent/CN111195228A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111821331A (en) * | 2020-07-21 | 2020-10-27 | 昆明医科大学 | External gel for repelling mosquitoes, relieving itching and diminishing swelling and preparation method thereof |
| CN112704651A (en) * | 2021-01-12 | 2021-04-27 | 四川嗨葆生物科技有限公司 | Mosquito repellent and preparation method thereof |
| CN114938804A (en) * | 2022-06-15 | 2022-08-26 | 王泽君 | Menthol-based mosquito repellent liquid composition and preparation method thereof |
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