CN111184694A - Preparation method of oral instant granules - Google Patents
Preparation method of oral instant granules Download PDFInfo
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- CN111184694A CN111184694A CN202010061893.6A CN202010061893A CN111184694A CN 111184694 A CN111184694 A CN 111184694A CN 202010061893 A CN202010061893 A CN 202010061893A CN 111184694 A CN111184694 A CN 111184694A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
Abstract
The invention discloses a preparation method of oral instant granules, which comprises the oral instant granules, wherein the oral instant granules are prepared from an outer-coated capsule and internal instant granules, the outer side of the outer-coated capsule is coated with sugar coatings, the outer-coated capsule is prepared from edible gelatin and pectin, and the internal instant granules comprise carrier aggregate and pharmaceutical factors. The carrier aggregate carries the drug factors, so that the drug is uniformly distributed, the drug taste and the bitter taste are effectively covered, the popping candy effect is generated after taking, the taste and the flavor are unique, the interestingness is realized, the dissolution of the particles is further accelerated, the external capsule is filled with the built-in instant particles, the storage and the moisture prevention of the particles are facilitated, the sugar coating is coated outside the external capsule, the tightness of the drug factors is improved, the anti-oxidant is matched, the drug effect of the drug factors is kept, meanwhile, the sugar coating is made of tartaric acid, the taste buds are stimulated, the oral liquid is increased, the drug factors are released and moistened, the potential safety hazard that the particles enter the trachea is reduced, and.
Description
Technical Field
The invention relates to the technical field of medicine preparation, in particular to a preparation method of oral instant granules.
Background
The oral instant tablet is a new dosage form which is developed rapidly in recent years, and can be disintegrated or dissolved in the oral cavity without water. The preparation is suitable for children and the old, is also suitable for mental disease patients, patients who cannot stand after operation, patients who have difficulty in swallowing and the like, and has good application value. The method for preparing the oral instant tablets is various and can be roughly divided into a freeze drying method, direct powder tabletting and wet granulation tabletting. Wherein, the manufacturing process of wet granulation tabletting is simple, the production cost is relatively low, and the development is fastest in the 3 preparation methods. Granulation is a very important link, and has a direct influence on the instant effect of the oral instant tablets. The like products also contain oral instant film agents.
At present, various instant medicines can quickly control the state of an illness, and when the medicine is actually used, if the medicine is instant in a granular shape, the medicine can be absorbed more quickly, but the medicine has poor taste due to the existence of medicine factors, medicine taste and bitter taste, the dose is not convenient to control, and in addition, the granules are easily sucked into organs to cause respiratory tract injury.
Therefore, it is necessary to invent a preparation method of instant oral granules to solve the above problems.
Disclosure of Invention
The invention aims to provide a preparation method of oral instant granules, which is characterized in that a carrier aggregate is prepared and carries medicinal factors, so that the medicine is uniformly distributed, the medicinal taste and the bitter taste can be effectively covered, the jumping of carbon dioxide small bubbles is matched to generate a jumping candy effect, the taste and the flavor are unique, the interestingness is realized, the granule dissolution can be further accelerated, the outer capsule is filled with the internal instant granules, the granule storage and the moisture resistance are facilitated, the outer side of the outer capsule is coated with a sugar coating, the tightness of the medicinal factors is improved, the medicinal effects of the medicinal factors are kept by matching with an antioxidant, meanwhile, the sugar coating is made of fruit acid, taste buds are stimulated to increase oral liquid, the internal instant granules can be rapidly dissolved after the outer capsule is bitten, the medicinal factors are released and moistened and adhered, the potential safety hazard of the granules entering air tubes is reduced, and the medicine absorption is.
In order to achieve the above purpose, the invention provides the following technical scheme: the preparation method of the oral instant granules comprises the oral instant granules, wherein the oral instant granules are prepared from an outer capsule and inner instant granules, the outer side of the outer capsule is coated with sugar coatings, the outer capsule is prepared from edible gelatin and pectin, the inner instant granules comprise carrier aggregates and pharmaceutical factors, the carrier aggregates are prepared from Arabic gum, mannitol, antioxidants, sweeteners and essences, the pharmaceutical factors are set to be nano-powder, and the preparation method of the oral instant granules comprises the following specific operation steps:
the method comprises the following steps: extracting medicine essence, eluting impurities after dissolving, distilling out solid medicine, and crushing the solid medicine into nano powder as a medicine factor for later use;
step two: preparing carrier aggregate by using Arabic gum, mannitol, an antioxidant, a sweetener and essence, firstly heating and melting the Arabic gum, adding the mannitol, the antioxidant, the sweetener and the essence, uniformly stirring, introducing 650psi of carbon dioxide gas into the mixture in a sealed environment while the mixture is hot after the mixture is uniform until the air pressure of the sealed environment rises to 4-5MPa, taking out the mixture, rapidly cooling the mixture in the air, cooling the mixture saturated with high-pressure bubbles, then expanding the mixture by the gas in the mixture, crushing the mixture into blocks, refining the block mixture by using a crusher, and uniformly processing the particle size to prepare a carrier aggregate substrate;
step three: heating the carrier aggregate substrate to melt the surface of the carrier aggregate substrate, melting sharp edges and corners to form a round surface, spreading the medicament factors on the inclined plane plate, putting the carrier aggregate substrate from the top of the inclined plane plate, shaking and screening the inclined plane plate, finally rolling the carrier aggregate substrate off the inclined plane plate, wrapping the medicament factors on the outer side of the carrier aggregate substrate, and preparing built-in instant granules for later use;
step four: preparing an outer-coated capsule, melting edible gelatin and pectin, mixing, producing the outer-coated capsule by using a capsule machine by using a conventional method, and sealing and packaging for later use;
step five: filling the built-in instant granules into the outer capsule according to the dosage, putting the filled outer capsule into a sugar coating machine, coating sugar coatings on the outer side of the outer capsule, and then sealing and packaging the finished product to finish the preparation of the oral instant granules.
Preferably, the mass ratio of the edible gelatin to the pectin in the outer capsule is set as the following: 2-3 of pectin: 1.
preferably, the average particle size of the carrier aggregate substrate is set to be 0.3-0.5mm, and the volume ratio of the carrier aggregate to the pharmaceutical agent is set to be 1-2: 1.
preferably, the glaze is made from fruit acid extracted from one of pineapple, lemon, grape, green apple, hawthorn and blueberry.
Preferably, the antioxidant is honey, the sweetener is one of stevioside, liquorice and sodium cyclamate, and the essence is fruit essence or emulsified essence.
Preferably, the mass ratio of the arabic gum to the mannitol to the antioxidant to the sweetener to the essence is set as the following: mannitol: antioxidant: a sweetening agent: 10-12 parts of essence: 1-2: 2-3: 1-3: 1-2.
Preferably, the heating temperature in the second step is set to be 120-.
In the technical scheme, the invention provides the following technical effects and advantages:
1. the carrier aggregate is prepared and carries the medicine factors, so that the medicine is uniformly distributed, the medicine taste and the bitter taste can be effectively covered, the jumping candy effect is generated by matching the jumping of small bubbles of carbon dioxide, the taste and the flavor are unique, the interestingness is realized, the dissolution of the granules can be further accelerated, the external capsule is loaded with the built-in instant granules, the storage and the moisture prevention of the granules are facilitated, the outer side of the external capsule is coated with the sugar coating, the tightness of the medicine factors is improved, the medicine effect of the medicine factors is maintained by matching with an antioxidant, meanwhile, the sugar coating is prepared from fruit acid, the taste buds are stimulated to increase the oral liquid, the built-in instant granules can be rapidly dissolved after the external capsule is bitten, the medicine factors are released and moistened, the potential safety;
2. by adding the raw materials such as the Arabic gum, the edible gelatin, the pectin and the like, a large amount of dietary fiber is provided, the intestinal peristalsis is promoted, the residual erosion of the medicinal factors to intestines and stomach is reduced, and meanwhile, the dietary fiber can be combined with heavy metals to achieve the effect of preventing and eliminating heavy metal poisoning in vivo.
Detailed Description
The present invention will be described in further detail below in order to enable those skilled in the art to better understand the technical solution of the present invention.
Example 1:
the invention provides a preparation method of oral instant particles, which comprises the oral instant particles, wherein the oral instant particles are prepared from an outer capsule and inner instant particles, the outer side of the outer capsule is coated with sugar coatings, the outer capsule is prepared from edible gelatin and pectin, the inner instant particles comprise carrier aggregates and pharmaceutical factors, the carrier aggregates are prepared from Arabic gum, mannitol, antioxidants, sweetening agents and essence, the antioxidants are honey, the sweetening agents are stevioside, the essence is fruit essence, and the pharmaceutical factors are nano-powder, and the preparation method of the oral instant particles comprises the following specific operation steps:
the method comprises the following steps: extracting medicine essence, eluting impurities after dissolving, distilling out solid medicine, and crushing the solid medicine into nano powder as a medicine factor for later use;
step two: preparing carrier aggregate by using Arabic gum, mannitol, an antioxidant, a sweetening agent and essence, wherein the mass ratio of the Arabic gum to the mannitol to the antioxidant to the sweetening agent to the essence is set as Arabic gum: mannitol: antioxidant: a sweetening agent: 10 parts of essence: 1: 2: 1: 1, firstly heating and melting Arabic gum, adding mannitol, an antioxidant, a sweetening agent and essence, uniformly stirring, introducing carbon dioxide gas with the pressure of 600psi into a mixture of the Arabic gum and the Arabic gum in a sealed environment while the Arabic gum is hot after the Arabic gum is uniform, setting the heating temperature of the mixture to be 120 ℃, setting the stirring speed to be 300r/min, setting the stirring time to be 1h, setting the temperature of the mixture to be 60 ℃ when the carbon dioxide gas is introduced, raising the temperature of the mixture to be 4MPa when the pressure of the sealed environment is raised, taking out the mixture, rapidly cooling the mixture in the air, expanding the mixture containing high-pressure bubbles by the gas inside after the mixture is cooled, crushing the mixture into blocks, refining the block mixture by using a crusher, uniformly processing the particle size, setting the average particle size of a carrier aggregate substrate to be: 1, preparing a carrier aggregate substrate;
step three: heating the carrier aggregate substrate to melt the surface of the carrier aggregate substrate, melting sharp edges and corners to form a round surface, spreading the medicament factors on the inclined plane plate, putting the carrier aggregate substrate from the top of the inclined plane plate, shaking and screening the inclined plane plate, finally rolling the carrier aggregate substrate off the inclined plane plate, wrapping the medicament factors on the outer side of the carrier aggregate substrate, and preparing built-in instant granules for later use;
step four: preparing an outer-coated capsule, melting edible gelatin and pectin, and mixing, wherein the mass ratio of the edible gelatin to the pectin is as follows: pectin 2: 1, producing an outer-coated capsule by using a capsule machine by using a conventional method, and sealing and packaging for later use;
step five: filling the built-in instant granules into the outer capsule according to the dosage, putting the filled outer capsule into a sugar coating machine, coating sugar coatings on the outer side of the outer capsule, wherein the sugar coatings are made of fruit acid, the fruit acid is extracted from green apples, and then sealing and packaging the finished product to finish the preparation of the oral instant granules.
The oral instant granules prepared in the embodiment carry uniform medicine amount, the medicine dosage is convenient to control through capsules, and the medicine is fast in dissolving speed, soft and not irritant, good in taste and high in safety degree, in addition, after the built-in instant granules prepared in the technical scheme are added into water, the built-in instant granules are completely dissolved after 2.8 seconds, 20 volunteers with the age of 20-60 years are randomly extracted, dandelion powder is used as a medicine factor, the oral instant granules capable of clearing away heat and toxic materials are produced and are provided for 20 volunteers to take, 1 person considers that the oral instant granules have medicine taste, no person takes medicine and then has an inappropriate reaction, the medicine jumps to be fast dissolved after entering the oral cavity, the taste is unique, the flavor and the taste of the medicine are evaluated according to a grading standard of 1-10 minutes, and the result shows that: the evaluation mean value of the medicine flavor is 6 points, the evaluation mean value of the taste is 9 points, the product acceptance is 89.3 percent, and the medicine can be welcomed by consumers.
Example 2:
the invention provides a preparation method of oral instant particles, which comprises the oral instant particles, wherein the oral instant particles are prepared from an outer capsule and inner instant particles, the outer side of the outer capsule is coated with sugar coatings, the outer capsule is prepared from edible gelatin and pectin, the inner instant particles comprise carrier aggregates and pharmaceutical factors, the carrier aggregates are prepared from Arabic gum, mannitol, antioxidants, sweetening agents and essence, the antioxidants are honey, the sweetening agents are stevioside, the essence is fruit essence, and the pharmaceutical factors are nano-powder, and the preparation method of the oral instant particles comprises the following specific operation steps:
the method comprises the following steps: extracting medicine essence, eluting impurities after dissolving, distilling out solid medicine, and crushing the solid medicine into nano powder as a medicine factor for later use;
step two: preparing carrier aggregate by using Arabic gum, mannitol, an antioxidant, a sweetening agent and essence, wherein the mass ratio of the Arabic gum to the mannitol to the antioxidant to the sweetening agent to the essence is set as Arabic gum: mannitol: antioxidant: a sweetening agent: essence 11: 1.5: 2.5: 2: 1.5, firstly heating and melting Arabic gum, adding mannitol, an antioxidant, a sweetening agent and essence, uniformly stirring, introducing 630psi carbon dioxide gas into a mixture of the Arabic gum and the Arabic gum in a sealed environment while the Arabic gum is hot, setting the heating temperature of the mixture to be 130 ℃, setting the stirring speed to be 350r/min, setting the stirring time to be 1.5h, setting the temperature of the mixture to be 70 ℃ when the carbon dioxide gas is introduced until the pressure of the sealed environment rises to 4.5MPa, taking out the mixture, placing the mixture in the air for rapid cooling, cooling the mixture saturated with high-pressure bubbles, then expanding and breaking the mixture into blocks by the gas inside, refining the block mixture by using a crusher, uniformly processing the particle size, setting the average particle size of a carrier aggregate substrate to be 0.4mm, and setting the volume ratio of the carrier aggregate to a pharmaceutical factor to be 1: 1, preparing a carrier aggregate substrate;
step three: heating the carrier aggregate substrate to melt the surface of the carrier aggregate substrate, melting sharp edges and corners to form a round surface, spreading the medicament factors on the inclined plane plate, putting the carrier aggregate substrate from the top of the inclined plane plate, shaking and screening the inclined plane plate, finally rolling the carrier aggregate substrate off the inclined plane plate, wrapping the medicament factors on the outer side of the carrier aggregate substrate, and preparing built-in instant granules for later use;
step four: preparing an outer-coated capsule, melting edible gelatin and pectin, and mixing, wherein the mass ratio of the edible gelatin to the pectin is as follows: pectin 2.5: 1, producing an outer-coated capsule by using a capsule machine by using a conventional method, and sealing and packaging for later use;
step five: filling the built-in instant granules into the outer capsule according to the dosage, putting the filled outer capsule into a sugar coating machine, coating sugar coatings on the outer side of the outer capsule, wherein the sugar coatings are made of fruit acid, the fruit acid is extracted from green apples, and then sealing and packaging the finished product to finish the preparation of the oral instant granules.
Comparative example 1, the oral instant granule prepared in this embodiment carries an even amount of medicine, it is convenient to control the dosage through the capsule, and the medicine dissolves fastly, it is soft not amazing, the taste is good, the degree of safety is high, in addition, after adding water to the built-in instant granule prepared in this technical scheme, the built-in instant granule dissolves completely after 2.3s, 20 volunteers of 20 years old age are drawn at random, use dandelion powder as the drug factor, produce heat-clearing and detoxicating oral instant granule, and after providing 20 volunteers to take, nobody thinks there is the drug taste, there is the maladaptation reaction after nobody takes the medicine, the medicine jumps to dissolve fast after entering the oral cavity, the taste is unique, the flavor and the taste of this medicine are evaluated with the score standard of 1-10 minutes, the result shows: the evaluation mean value of the medicine flavor is 9 points, the evaluation mean value of the taste is 10 points, the product acceptance is 98.6 percent, and the medicine can be welcomed by consumers.
Example 3:
the invention provides a preparation method of oral instant particles, which comprises the oral instant particles, wherein the oral instant particles are prepared from an outer capsule and inner instant particles, the outer side of the outer capsule is coated with sugar coatings, the outer capsule is prepared from edible gelatin and pectin, the inner instant particles comprise carrier aggregates and pharmaceutical factors, the carrier aggregates are prepared from Arabic gum, mannitol, antioxidants, sweetening agents and essence, the antioxidants are honey, the sweetening agents are stevioside, the essence is fruit essence, and the pharmaceutical factors are nano-powder, and the preparation method of the oral instant particles comprises the following specific operation steps:
the method comprises the following steps: extracting medicine essence, eluting impurities after dissolving, distilling out solid medicine, and crushing the solid medicine into nano powder as a medicine factor for later use;
step two: preparing carrier aggregate by using Arabic gum, mannitol, an antioxidant, a sweetening agent and essence, wherein the mass ratio of the Arabic gum to the mannitol to the antioxidant to the sweetening agent to the essence is set as Arabic gum: mannitol: antioxidant: a sweetening agent: 112 parts of essence: 2: 3: 3: 2, firstly heating and melting Arabic gum, adding mannitol, an antioxidant, a sweetening agent and essence, uniformly stirring, introducing 650psi carbon dioxide gas into a mixture of the Arabic gum and the Arabic gum in a sealed environment while the Arabic gum is hot after the Arabic gum is uniform, setting the heating temperature of the mixture to be 150 ℃, setting the stirring speed to be 400r/min, setting the stirring time to be 2h, setting the temperature of the mixture to be 80 ℃ when the carbon dioxide gas is introduced, raising the temperature of the mixture to be 5MPa when the pressure of the sealed environment is raised, taking out the mixture, rapidly cooling the mixture in the air, expanding the mixture containing high-pressure bubbles by the gas in the mixture after the mixture is cooled, crushing the mixture into blocks, refining the block mixture by using a crusher, uniformly processing the particle size, setting the average particle size of a carrier aggregate substrate to be 0.: 1, preparing a carrier aggregate substrate;
step three: heating the carrier aggregate substrate to melt the surface of the carrier aggregate substrate, melting sharp edges and corners to form a round surface, spreading the medicament factors on the inclined plane plate, putting the carrier aggregate substrate from the top of the inclined plane plate, shaking and screening the inclined plane plate, finally rolling the carrier aggregate substrate off the inclined plane plate, wrapping the medicament factors on the outer side of the carrier aggregate substrate, and preparing built-in instant granules for later use;
step four: preparing an outer-coated capsule, melting edible gelatin and pectin, and mixing, wherein the mass ratio of the edible gelatin to the pectin is as follows: pectin 3: 1, producing an outer-coated capsule by using a capsule machine by using a conventional method, and sealing and packaging for later use;
step five: filling the built-in instant granules into the outer capsule according to the dosage, putting the filled outer capsule into a sugar coating machine, coating sugar coatings on the outer side of the outer capsule, wherein the sugar coatings are made of fruit acid, the fruit acid is extracted from green apples, and then sealing and packaging the finished product to finish the preparation of the oral instant granules.
Comparing embodiment 1 and 2, the oral cavity instant granule prepared in this embodiment carries the medicine volume evenly, be convenient for control the dose through the capsule, and the medicine dissolves fastly, it is soft not amazing, the taste is good, the degree of safety is high, in addition, after adding water with the built-in instant granule that this technical scheme prepared, built-in instant granule dissolves completely after 2.8s, 20 volunteers of age bracket 20-60 years old are drawn at random, use dandelion powder as the drug factor, produce heat-clearing and detoxicating oral cavity instant granule, and after providing 20 volunteers to take, nobody thinks there is the drug taste, there is the maladaptation reaction after nobody takes the medicine, the medicine jumps to dissolve fast after entering the oral cavity, the taste is unique, with the flavor and the taste of this medicine of 1-10 minute's score standard evaluation, the result shows: the evaluation mean value of the medicine flavor is 8 points, the evaluation mean value of the taste is 9 points, the product acceptance is 92.7 percent, and the medicine can be welcomed by consumers.
The following table is obtained according to examples 1 to 3:
as can be seen from the above table, the raw materials in example 2 have moderate proportions and moderate processing temperatures, the instant oral granules in this example have the fastest dissolution rate and the highest product acceptance and are most popular with consumers, therefore, the preparation method provided in example 2 is most suitable for popularization and application of the production and preparation method of instant oral granules, and the acacia gum, the mannitol, the antioxidant, the sweetener and the essence are used for preparing the carrier aggregate, and the carrier aggregate carries the drug factors, so that the drug is uniformly distributed, the drug taste and the bitter taste can be effectively covered, the carbon dioxide small bubbles can be matched to bounce out to generate the effect of jumping candy, the taste and the flavor are unique and interesting, the dissolution of the granules can be further accelerated, the outer capsule prepared by using the edible gelatin and the pectin is loaded with the built-in instant granules, the storage and the moisture prevention of the granules are facilitated, the outer side of the outer capsule is coated with, the compound pectin dietary cellulose can promote intestinal peristalsis, and can be combined with heavy metal to prevent and eliminate heavy metal in vivo.
While certain exemplary embodiments of the present invention have been described above by way of illustration only, it will be apparent to those of ordinary skill in the art that the described embodiments may be modified in various different ways without departing from the spirit and scope of the invention. Therefore, the above description is illustrative in nature and should not be construed as limiting the scope of the invention, which is defined by the appended claims, and any modifications, equivalents, improvements and the like, which come within the spirit and scope of the invention are intended to be embraced therein.
Claims (7)
1. A preparation method of an oral instant granule comprises the oral instant granule, and is characterized in that: the oral instant granules are prepared from an outer capsule and inner instant granules, the outer side of the outer capsule is coated with sugar coatings, the outer capsule is prepared from edible gelatin and pectin, the inner instant granules comprise carrier aggregates and pharmaceutical factors, the carrier aggregates are prepared from Arabic gum, mannitol, antioxidants, sweetening agents and essence, the pharmaceutical factors are set to be nano-powder, and the preparation method of the oral instant granules comprises the following specific operation steps:
the method comprises the following steps: extracting medicine essence, eluting impurities after dissolving, distilling out solid medicine, and crushing the solid medicine into nano powder as a medicine factor for later use;
step two: preparing carrier aggregate by using Arabic gum, mannitol, an antioxidant, a sweetener and essence, firstly heating and melting the Arabic gum, adding the mannitol, the antioxidant, the sweetener and the essence, uniformly stirring, introducing 650psi of carbon dioxide gas into the mixture in a sealed environment while the mixture is hot after the mixture is uniform until the air pressure of the sealed environment rises to 4-5MPa, taking out the mixture, rapidly cooling the mixture in the air, cooling the mixture saturated with high-pressure bubbles, then expanding the mixture by the gas in the mixture, crushing the mixture into blocks, refining the block mixture by using a crusher, and uniformly processing the particle size to prepare a carrier aggregate substrate;
step three: heating the carrier aggregate substrate to melt the surface of the carrier aggregate substrate, melting sharp edges and corners to form a round surface, spreading the medicament factors on the inclined plane plate, putting the carrier aggregate substrate from the top of the inclined plane plate, shaking and screening the inclined plane plate, finally rolling the carrier aggregate substrate off the inclined plane plate, wrapping the medicament factors on the outer side of the carrier aggregate substrate, and preparing built-in instant granules for later use;
step four: preparing an outer-coated capsule, melting edible gelatin and pectin, mixing, producing the outer-coated capsule by using a capsule machine by using a conventional method, and sealing and packaging for later use;
step five: filling the built-in instant granules into the outer capsule according to the dosage, putting the filled outer capsule into a sugar coating machine, coating sugar coatings on the outer side of the outer capsule, and then sealing and packaging the finished product to finish the preparation of the oral instant granules.
2. The method of claim 1, wherein the step of preparing the orally fast dissolving granules comprises: the mass ratio of the edible gelatin to the pectin in the outer capsule is as follows: 2-3 of pectin: 1.
3. the method of claim 1, wherein the step of preparing the orally fast dissolving granules comprises: the average particle size of the carrier aggregate base material is set to be 0.3-0.5mm, and the volume ratio of the carrier aggregate to the pharmaceutical factor is set to be 1-2: 1.
4. the method of claim 1, wherein the step of preparing the orally fast dissolving granules comprises: the sugar coating is made from fruit acid extracted from one of pineapple, lemon, grape, green apple, hawthorn and blueberry.
5. The method of claim 1, wherein the step of preparing the orally fast dissolving granules comprises: the antioxidant is set to be honey, the sweetener is set to be one of stevioside, liquorice and sodium cyclamate, and the essence is set to be fruit essence or emulsified essence.
6. The method of claim 1, wherein the step of preparing the orally fast dissolving granules comprises: the mass ratio of the arabic gum to the mannitol to the antioxidant to the sweetener to the essence is set as the following: mannitol: antioxidant: a sweetening agent: 10-12 parts of essence: 1-2: 2-3: 1-3: 1-2.
7. The method of claim 1, wherein the step of preparing the orally fast dissolving granules comprises: in the second step, the heating temperature is set to be 120-150 ℃, the stirring speed is set to be 300-400r/min, the stirring time is set to be 1-2h, and the temperature of the mixture is 60-80 ℃ when the carbon dioxide gas is introduced.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113729222A (en) * | 2020-05-29 | 2021-12-03 | 李永川 | A food or health food containing endothelium corneum Gigeriae Galli for children and its preparation method |
| CN114831944A (en) * | 2022-04-08 | 2022-08-02 | 中国药科大学 | Medicinal granule with taste masking effect and application thereof |
| CN114886858A (en) * | 2022-04-08 | 2022-08-12 | 中国药科大学 | Corrective medicinal adjuvant composition and application thereof |
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| CN114831944A (en) * | 2022-04-08 | 2022-08-02 | 中国药科大学 | Medicinal granule with taste masking effect and application thereof |
| CN114886858A (en) * | 2022-04-08 | 2022-08-12 | 中国药科大学 | Corrective medicinal adjuvant composition and application thereof |
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